MCID: PRL014
MIFTS: 29

Paralytic Squint

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Paralytic Squint

MalaCards integrated aliases for Paralytic Squint:

Name: Paralytic Squint 12 15
Paralytic Strabismus 12 17 72 33
Incomitant Dissociation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10863
ICD9CM 35 378.5 378.50
SNOMED-CT 68 12942001
ICD10 33 H49 H49.9
UMLS 72 C0152221

Summaries for Paralytic Squint

MalaCards based summary : Paralytic Squint, also known as paralytic strabismus, is related to abducens nerve disease and cranial nerve palsy. An important gene associated with Paralytic Squint is CHN1 (Chimerin 1), and among its related pathways/superpathways is Glypican 1 network. Affiliated tissues include eye, testes and thyroid.

Wikipedia : 75 Strabismus is a condition in which the eyes do not properly align with each other when looking at an... more...

Related Diseases for Paralytic Squint

Diseases related to Paralytic Squint via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 abducens nerve disease 31.5 SAMHD1 PRL CHN1
2 cranial nerve palsy 31.4 NT5C3A CHN1
3 tukel syndrome 31.2 TUBB2B PHOX2A KIF21A CHN1
4 exotropia 31.0 PHOX2A KIF21A CHN1
5 strabismus 30.4 PHOX2A KIF21A CHN1
6 fourth cranial nerve palsy 29.8 RANBP2 PRNP PRL HCK CHN1
7 kearns-sayre syndrome 10.6
8 tolosa-hunt syndrome 10.5
9 fibrosis of extraocular muscles, congenital, 2 10.5 PHOX2A KIF21A
10 fourth cranial nerve palsy, familial congenital 10.4
11 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 1 10.4
12 gaze palsy, familial horizontal, with progressive scoliosis 1 10.4
13 oculomotor nerve paralysis 10.4
14 chronic progressive external ophthalmoplegia 10.4
15 trochlear nerve disease 10.4
16 autosomal dominant progressive external ophthalmoplegia 10.4
17 mitochondrial dna-related progressive external ophthalmoplegia 10.4
18 congenital trochlear nerve palsy 10.4
19 cranial nerve disease 10.3 PHOX2A KIF21A CHN1
20 facial nerve disease 10.3 PHOX2A KIF21A CADM1
21 duane retraction syndrome 10.3 KIF21A EPHA4 CHN1
22 xerophthalmia 10.3 GABBR1 CADM1
23 ptosis 10.2
24 alternating exotropia 10.2
25 hypertropia 10.2 SAMHD1 KIF21A CHN1
26 lyme disease 10.2
27 myopia 10.2
28 ocular motility disease 10.1 PHOX2A NT5C3A KIF21A CHN1
29 hypotropia 10.1 SAMHD1 PHOX2A KIF21A CHN1
30 cauda equina syndrome 10.1
31 mononeuropathy 10.1
32 dengue disease 10.1
33 dengue hemorrhagic fever 10.1
34 guillain-barre syndrome 10.1
35 optic nerve disease 10.1
36 myelitis 10.1
37 polyradiculopathy 10.1
38 transverse myelitis 10.1
39 congenital ptosis 10.1 KIF21A CHN1
40 monocular esotropia 10.1
41 mechanical strabismus 10.1
42 esotropia 10.1
43 abducens palsy 10.0
44 marfan syndrome 10.0
45 ocular dominance 10.0
46 myasthenia gravis 10.0
47 thrombosis 10.0
48 suppression amblyopia 10.0
49 amblyopia 10.0
50 vascular disease 10.0

Graphical network of the top 20 diseases related to Paralytic Squint:



Diseases related to Paralytic Squint

Symptoms & Phenotypes for Paralytic Squint

Drugs & Therapeutics for Paralytic Squint

Search Clinical Trials , NIH Clinical Center for Paralytic Squint

Genetic Tests for Paralytic Squint

Anatomical Context for Paralytic Squint

MalaCards organs/tissues related to Paralytic Squint:

41
Eye, Testes, Thyroid

Publications for Paralytic Squint

Articles related to Paralytic Squint:

(show top 50) (show all 181)
# Title Authors PMID Year
1
Don't Miss This! Red Flags in the Pediatric Eye Examination: Ophthalmoplegia in Childhood. 38
31329057 2019
2
Strabismus Is Correlated with Gross Motor Function in Children with Spastic Cerebral Palsy. 38
31189336 2019
3
Ophthalmologic Clinical Features of Facial Nerve Palsy Patients. 38
30746906 2019
4
Clinical Course and Prognostic Factors of Acquired Third, Fourth, and Sixth Cranial Nerve Palsy in Korean Patients. 38
29770635 2018
5
MRI findings of contralateral oculomotor nerve palsy in Parry-Romberg syndrome. 38
29780922 2018
6
Ocular motor cranial nerve palsy and increased risk of stroke in the general population. 38
30321220 2018
7
Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study. 38
28356250 2017
8
Ocular congenital cranial dysinnervation disorders (CCDDs): insights into axon growth and guidance. 38
28459979 2017
9
Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome. 38
28346224 2017
10
Changing Strabismus Surgery Distribution at Shanxi Province Eye Hospital in Central China. 38
27977036 2017
11
Early Onset Sixth-Nerve Palsy with Eccentric Fixation. 38
28904218 2017
12
Two unique TUBB3 mutations cause both CFEOM3 and malformations of cortical development. 38
26639658 2016
13
Ocular Complications in Children with Diabetes Mellitus. 38
26341461 2015
14
The Role of Extraocular Muscle Pulleys in Incomitant Non-Paralytic Strabismus. 38
26180464 2015
15
Periosteal Fixation Procedures in the Management of Incomitant Strabismus. 38
26180470 2015
16
Muscle Union Procedure in Patients with Paralytic Strabismus. 38
26070148 2015
17
[Strabismus Sursoabductorius (put into the Context of eighteen Years of Strabismus Surgery Analysis)]. 38
26782915 2015
18
Paralytic strabismus and papilloedema caused by dural sinus thrombosis after bee sting. 38
25234425 2015
19
Incidence, types, and lifetime risk of adult-onset strabismus. 38
24321142 2014
20
Treatment of consecutive exotropia: unilateral lateral rectus recession combined with medial rectus advancement or resection. 38
24512646 2014
21
Strabismus surgery distribution during 10-year period in a tertiary hospital. 38
25131226 2014
22
[Partial rectus muscle transposition for strabismus with lateral rectus muscles paralysis]. 38
24257354 2013
23
Acquired paralytic strabismus in Southern Taiwan. 38
23608076 2013
24
Effectivity of intraoperative adjustable suture technique in horizontal strabismus. 38
23991385 2013
25
Strabismus among aged fee-for-service Medicare beneficiaries. 38
23158551 2012
26
Paralytic strabismus in South African Black and mixed race children--a 15-year clinic-based review. 38
23171209 2012
27
[Faden operations - indications beyond esotropia and surgical results]. 38
22826188 2012
28
A 6-year-old girl with restricted upward gaze of her right eye. 38
22855935 2012
29
Paralytic squint due to abducens nerve palsy: a rare consequence of dengue fever. 38
22799448 2012
30
Imaging of torticollis in children. 38
22411949 2012
31
Paralytic strabismus: third, fourth, and sixth nerve palsy. 38
20638001 2010
32
A 4 year retrospective survey of strabismus surgery in Tongren Eye Centre Beijing. 38
20444139 2010
33
[Study on acupuncture for treatment of oculomotor paralysis according to syndrome differentiation of meridians]. 38
20214071 2010
34
[Clinical observation on acupuncture for treatment of paralytic strabismus]. 38
19873915 2009
35
Exotropia caused by pit viper snakebite. 38
19683199 2009
36
Minimally invasive strabismus surgery (MISS) for rectus muscle transpositions. 38
19211600 2009
37
Five cases of paralytic strabismus as a rare feature of lyme disease. 38
19193112 2009
38
Behavioural and electrophysiological analysis of strabismus in cats: modern context. 38
18618102 2009
39
[Central nervous system abnormalities related to congenital fibrosis of extraocular muscles]. 38
19228463 2009
40
Rectus muscle posterior tenon fixation as an inactivation procedure. 38
18538301 2008
41
[Observation on therapeutic effect of acupuncture combined with western medicine on paralytic strabismus]. 38
18630533 2008
42
[Randomized controlled study on acupuncture for treatment of diabetic paralytic squint]. 38
18405147 2008
43
General principles in the surgical treatment of paralytic strabismus. 38
21149177 2008
44
Ocular involvement in children with localised scleroderma: a multi-centre study. 38
17475707 2007
45
[Paralytic strabismus: review of 24 years at "Santa Casa de São Paulo"]. 38
17906751 2007
46
[Therapeutic options in III. nerve paralysis]. 38
17605267 2007
47
[The application of botulinum toxin A in the treatment of restrictive strabismus in thyroid associated ophthalmopathy]. 38
17415961 2006
48
Filamentary keratopathy caused by corneal occlusion by large-angle paralytic strabismus. 38
17133065 2006
49
The influence of adaptation on visual motion detection in chronic sixth nerve palsy after treatment with botulinum toxin. 38
16950741 2006
50
Suture fixation system as globe tethers in severe paralytic strabismus. 38
16935240 2006

Variations for Paralytic Squint

Expression for Paralytic Squint

Search GEO for disease gene expression data for Paralytic Squint.

Pathways for Paralytic Squint

Pathways related to Paralytic Squint according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.04 PRNP HCK

GO Terms for Paralytic Squint

Cellular components related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Schaffer collateral - CA1 synapse GO:0098685 8.8 TUBB2B GABBR1 EPHA4

Biological processes related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte chemotaxis GO:0030595 9.16 PPBP PF4
2 motor neuron axon guidance GO:0008045 8.96 EPHA4 CHN1
3 negative regulation of long-term synaptic potentiation GO:1900272 8.62 PRNP EPHA4

Molecular functions related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 TUBB2B SSNA1 SAMHD1 RANBP2 PRNP PRL

Sources for Paralytic Squint

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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