MCID: PRL014
MIFTS: 30

Paralytic Squint

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Paralytic Squint

MalaCards integrated aliases for Paralytic Squint:

Name: Paralytic Squint 12 15
Paralytic Strabismus 12 73
Incomitant Dissociation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10863
ICD10 33 H49 H49.9
ICD9CM 35 378.5 378.50
SNOMED-CT 68 12942001
UMLS 73 C0152221

Summaries for Paralytic Squint

MalaCards based summary : Paralytic Squint, also known as paralytic strabismus, is related to strabismus and kearns-sayre syndrome. An important gene associated with Paralytic Squint is TUBB3 (Tubulin Beta 3 Class III), and among its related pathways/superpathways is Glypican 1 network. The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder. Affiliated tissues include eye and testes.

Wikipedia : 76 Strabismus, also known as crossed eyes, is a condition in which the eyes do not properly align with each... more...

Related Diseases for Paralytic Squint

Diseases related to Paralytic Squint via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 strabismus 31.4 TUBB3 PHOX2A KIF21A CHN1
2 kearns-sayre syndrome 30.9 TUBB3 PHOX2A KIF21A
3 abducens nerve disease 30.8 SAMHD1 PRL KANTR CHN1
4 tukel syndrome 30.6 TUBB3 TUBB2B PHOX2A KIF21A CHN1
5 oculomotor nerve paralysis 30.5 KANTR CHN1
6 fourth cranial nerve palsy 30.0 RANBP2 PRNP PRL HCK CHN1
7 tolosa-hunt syndrome 10.4
8 tubulinopathy-associated dysgyria 10.3 TUBB3 TUBB2B
9 fibrosis of extraocular muscles, congenital, 2 10.3 PHOX2A KIF21A
10 marcus gunn phenomenon 10.2 TUBB3 CHN1
11 ovarian carcinosarcoma 10.2 TUBB3 FUT2
12 fourth cranial nerve palsy, familial congenital 10.2
13 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 1 10.2
14 gaze palsy, familial horizontal, with progressive scoliosis, 1 10.2
15 total third-nerve palsy 10.2
16 chronic progressive external ophthalmoplegia 10.2
17 trochlear nerve disease 10.2
18 autosomal dominant progressive external ophthalmoplegia 10.2
19 maternally-inherited progressive external ophthalmoplegia 10.2
20 congenital trochlear nerve palsy 10.2
21 amblyopia 10.2 TUBB3 PHOX2A CHN1
22 congenital ptosis 10.2 TUBB3 KIF21A CHN1
23 deafness, autosomal dominant 28 10.2 TUBB3 KIF21A CHN1
24 moebius syndrome 10.2 TUBB3 PHOX2A
25 ptosis 10.2 TUBB3 PHOX2A KIF21A
26 neonatal anemia 10.2 TUBB3 TUBB2B
27 xerophthalmia 10.2 GABBR1 CADM1
28 alternating esotropia 10.2 KANTR CHN1
29 accommodative esotropia 10.1 KANTR CHN1
30 exotropia 10.1 TUBB3 PHOX2A KIF21A CHN1
31 lyme disease 10.1
32 mechanical strabismus 10.1
33 third cranial nerve disease 10.1 KANTR CHN1
34 duane retraction syndrome 10.1 TUBB3 KIF21A EPHA4 CHN1
35 dengue virus 10.1
36 dengue disease 10.1
37 pylorospasm 10.1 KANTR HCK
38 anismus 10.1 KANTR FUT2
39 facial paralysis 10.1 TUBB3 CADM1
40 hyperhidrosis, gustatory 10.1 KANTR HCK
41 anteroseptal myocardial infarction 10.0 KANTR FUT2
42 auditory agnosia 10.0 PRNP KANTR
43 exposure keratitis 10.0 TUBB3 KANTR
44 peripheral nervous system disease 10.0 TUBB3 KIF21A KANTR CHN1
45 tabes dorsalis 10.0 SH3BP5 KANTR
46 nervous system disease 10.0 TUBB3 PRNP KANTR
47 keratopathy 10.0
48 thrombosis 10.0
49 blepharospasm 10.0
50 esotropia 10.0

Graphical network of the top 20 diseases related to Paralytic Squint:



Diseases related to Paralytic Squint

Symptoms & Phenotypes for Paralytic Squint

Drugs & Therapeutics for Paralytic Squint

Drugs for Paralytic Squint (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 3 51-84-3 187
2 Botulinum Toxins Phase 3
3 Acetylcholine Release Inhibitors Phase 3
4 onabotulinumtoxinA Phase 3
5 Neurotransmitter Agents Phase 3
6 Cholinergic Agents Phase 3
7 Peripheral Nervous System Agents Phase 3
8 abobotulinumtoxinA Phase 3
9 Neuromuscular Agents Phase 3
10 Botulinum Toxins, Type A Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of GSK1358820 (Botulinum Toxin Type A) in Patients With Strabismus Completed NCT01584843 Phase 3 GSK1358820

Search NIH Clinical Center for Paralytic Squint

Genetic Tests for Paralytic Squint

Anatomical Context for Paralytic Squint

MalaCards organs/tissues related to Paralytic Squint:

41
Eye, Testes

Publications for Paralytic Squint

Articles related to Paralytic Squint:

(show top 50) (show all 57)
# Title Authors Year
1
Muscle Union Procedure in Patients with Paralytic Strabismus. ( 26070148 )
2015
2
The Role of Extraocular Muscle Pulleys in Incomitant Non-Paralytic Strabismus. ( 26180464 )
2015
3
Paralytic strabismus and papilloedema caused by dural sinus thrombosis after bee sting. ( 25234425 )
2014
4
Acquired paralytic strabismus in Southern Taiwan. ( 23608076 )
2013
5
Paralytic strabismus in South African Black and mixed race children--a 15-year clinic-based review. ( 23171209 )
2012
6
Paralytic squint due to abducens nerve palsy: a rare consequence of dengue fever. ( 22799448 )
2012
7
Paralytic strabismus: third, fourth, and sixth nerve palsy. ( 20638001 )
2010
8
Five cases of paralytic strabismus as a rare feature of lyme disease. ( 19193112 )
2009
9
General principles in the surgical treatment of paralytic strabismus. ( 21149177 )
2008
10
Filamentary keratopathy caused by corneal occlusion by large-angle paralytic strabismus. ( 17133065 )
2006
11
Suture fixation system as globe tethers in severe paralytic strabismus. ( 16935240 )
2006
12
Unilateral paralytic strabismus in the adult cat induces plastic changes in interocular disparity along the visual midline: contribution of the corpus callosum. ( 16079008 )
2005
13
Effect of full tendon transposition augmented with posterior intermuscular suture for paralytic strabismus. ( 16084787 )
2005
14
Paralytic strabismus as a manifestation of lyme borreliosis. ( 16193697 )
2005
15
Clinical observation on treatment of acquired paralytic strabismus by acupuncture plus oral administration of Chinese herbs. ( 14535181 )
2003
16
Rectus extraocular muscle pulley displacement after surgical transposition and posterior fixation for treatment of paralytic strabismus. ( 11755847 )
2002
17
Paralytic strabismus. ( 11588500 )
2001
18
Split rectus muscle modified Foster procedure for paralytic strabismus: a report of 5 cases. ( 11720594 )
2001
19
Strabismus surgery in the treatment of paralytic strabismus. ( 11734680 )
2001
20
Augmented Hummelsheim procedure for paralytic strabismus. ( 10955540 )
2000
21
Paralytic strabismus. ( 11148696 )
2000
22
Paralytic strabismus. ( 10621543 )
1999
23
The surgical correction of paralytic strabismus using fascia lata. ( 9503312 )
1998
24
Paralytic strabismus. ( 10387476 )
1998
25
Paralytic strabismus. ( 10159715 )
1995
26
Quantitative magnetic resonance morphometry of extraocular muscles: a new diagnostic tool in paralytic strabismus. ( 7931952 )
1994
27
Paralytic strabismus and syndromes. ( 10150809 )
1994
28
Botulinum toxin in the treatment of paralytic strabismus and essential blepharospasm. ( 8125543 )
1993
29
81 cases of paralytic strabismus treated with acupuncture. ( 8412281 )
1993
30
Saccadic velocity studies in paralytic strabismus: fixation with the paretic vs the nonparetic eye. ( 3977216 )
1985
31
Paralytic strabismus: the role of botulinum toxin. ( 4084480 )
1985
32
Paralytic squint treated with acupuncture. ( 6570146 )
1984
33
Paralytic strabismus correction by adjustable suture technique. ( 6370300 )
1984
34
Graphic analysis of paralytic strabismus with the Lancaster red-green test. ( 6720837 )
1984
35
Paralytic strabismus in children. Etiologic incidence and management of the third, fourth, and sixth nerve palsies. ( 7375084 )
1980
36
The use of prisms in paralytic squint. ( 900621 )
1977
37
Abnormal saccades in paralytic strabismus. ( 835653 )
1977
38
Management of non-paralytic strabismus in infants, with special reference to esotropia. ( 836771 )
1977
39
Measurement of the field of binocular single vision in the evaluation of incomitant paralytic strabismus. ( 4830090 )
1974
40
Management of paralytic strabismus. ( 4834599 )
1974
41
A surgery on twenty six thousand and three hundred seventy eight patients with convergent squint (26378), thirteen thousand, one hundred and eighty one patients with divergent squint (13181), one thousand and twenty nine patients of vertical squint (1029), ten thousand and one hundred thirty nine patients of heterophoria (10139) and two thousand sixty one patients of paralytic squint (2061) seen during the past ten years at Giza Ophthalmic Hospital Squint Clinic from the year 1960 to the year 1970. ( 4666806 )
1972
42
Diagnosis of paralytic squint. ( 5154750 )
1971
43
Past-pointing in paralytic strabismus. ( 5541186 )
1971
44
Past-pointing in paralytic strabismus. ( 5524218 )
1970
45
Operative treatment of paralytic strabismus. ( 5536726 )
1970
46
The diagnostic comparisons between congenital and acquired paralytic strabismus. ( 6035863 )
1967
47
The role of the orthoptist in the management of acquired paralytic strabismus. ( 5936924 )
1966
48
NON-PARALYTIC squint. ( 13450382 )
1957
49
Paralytic strabismus, with special reference to surgical treatment. ( 13295778 )
1955
50
Orthoptic and surgical treatment of non-paralytic strabismus. ( 13019422 )
1953

Variations for Paralytic Squint

Expression for Paralytic Squint

Search GEO for disease gene expression data for Paralytic Squint.

Pathways for Paralytic Squint

Pathways related to Paralytic Squint according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.04 HCK PRNP

GO Terms for Paralytic Squint

Cellular components related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Schaffer collateral - CA1 synapse GO:0098685 8.8 EPHA4 GABBR1 TUBB2B

Biological processes related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of axonogenesis GO:0050770 9.16 CHN1 EPHA4
2 motor neuron axon guidance GO:0008045 8.96 CHN1 EPHA4
3 negative regulation of long-term synaptic potentiation GO:1900272 8.62 EPHA4 PRNP

Molecular functions related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ephrin receptor binding GO:0046875 8.62 CHN1 EPHA4

Sources for Paralytic Squint

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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