MCID: PRL014
MIFTS: 29

Paralytic Squint

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Paralytic Squint

MalaCards integrated aliases for Paralytic Squint:

Name: Paralytic Squint 12 15
Paralytic Strabismus 12 17 71 32
Incomitant Dissociation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10863
ICD9CM 34 378.5
SNOMED-CT 67 400942002
ICD10 32 H49 H49.9
UMLS 71 C0152221

Summaries for Paralytic Squint

MalaCards based summary : Paralytic Squint, also known as paralytic strabismus, is related to abducens nerve disease and fourth cranial nerve palsy. An important gene associated with Paralytic Squint is KIF21A (Kinesin Family Member 21A). Affiliated tissues include eye, testes and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Strabismus is a condition in which the eyes do not properly align with each other when looking at an... more...

Related Diseases for Paralytic Squint

Diseases related to Paralytic Squint via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 abducens nerve disease 31.5 NT5C3A CHN1
2 fourth cranial nerve palsy 30.8 SEMA7A NT5C3A
3 ptosis 30.4 PHOX2A NT5C3A KIF21A
4 amblyopia 30.0 PHOX2A KIF21A CHN1
5 suppression amblyopia 29.6 PHOX2A MTRNR2L5
6 exotropia 29.6 SEMA7A PHOX2A NT5C3A KIF21A CHN1
7 tukel syndrome 29.4 TUBB2B TUBA1A PHOX2A NT5C3A KIF21A CHN1
8 esotropia 29.4 SEMA7A PHOX2A NT5C3A KIF21A CHN1
9 strabismus 29.0 TUBB2B SEMA7A PHOX2A NT5C3A KIF21A CHN1
10 kearns-sayre syndrome 10.6
11 tolosa-hunt syndrome 10.5
12 cranial nerve palsy 10.4
13 fourth cranial nerve palsy, familial congenital 10.4
14 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 1 10.4
15 oculomotor nerve paralysis 10.4
16 chronic progressive external ophthalmoplegia 10.4
17 trochlear nerve disease 10.4
18 horizontal gaze palsy with progressive scoliosis 10.4
19 autosomal dominant progressive external ophthalmoplegia 10.4
20 mitochondrial dna-related progressive external ophthalmoplegia 10.4
21 congenital trochlear nerve palsy 10.4
22 marcus gunn phenomenon 10.3 PHOX2A KIF21A
23 alternating exotropia 10.3
24 myotonic cataract 10.2 PHOX2A KIF21A
25 fibrosis of extraocular muscles, congenital, 2 10.2 PHOX2A KIF21A
26 joint laxity, short stature, and myopia 10.2
27 lyme disease 10.2
28 myopia 10.2
29 cauda equina syndrome 10.1
30 mononeuropathy 10.1
31 dengue disease 10.1
32 dengue hemorrhagic fever 10.1
33 guillain-barre syndrome 10.1
34 optic nerve disease 10.1
35 myelitis 10.1
36 polyradiculopathy 10.1
37 transverse myelitis 10.1
38 accommodative esotropia 10.1 PHOX2A CHN1
39 monocular esotropia 10.1
40 mechanical strabismus 10.1
41 microphthalmia, isolated 5 10.1 TUBB2B PHOX2A KIF21A
42 enophthalmos 10.1 PHOX2A NT5C3A
43 orbital disease 10.1 PHOX2A NT5C3A KIF21A
44 congenital ptosis 10.0 PHOX2A NT5C3A KIF21A
45 tubulinopathy-associated dysgyria 10.0 TUBB2B TUBA1A
46 abducens palsy 10.0
47 marfan syndrome 10.0
48 ocular dominance 10.0
49 myasthenia gravis 10.0
50 thrombosis 10.0

Graphical network of the top 20 diseases related to Paralytic Squint:



Diseases related to Paralytic Squint

Symptoms & Phenotypes for Paralytic Squint

GenomeRNAi Phenotypes related to Paralytic Squint according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.72 NT5C3A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.72 PHOX2A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.72 NT5C3A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.72 NT5C3A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.72 TUBA1A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.72 NT5C3A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.72 TUBA1A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.72 NT5C3A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.72 NT5C3A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.72 NT5C3A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-171 9.72 NT5C3A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.72 TUBA1A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.72 NT5C3A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-216 9.72 PHOX2A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.72 PHOX2A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.72 PHOX2A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.72 NT5C3A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.72 TUBA1A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.72 PHOX2A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-61 9.72 TUBA1A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.72 NT5C3A TUBA1A
22 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.72 NT5C3A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.72 PHOX2A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.72 TUBA1A

MGI Mouse Phenotypes related to Paralytic Squint:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.5 CHN1 DMRTA2 KIF21A PHOX2A SEMA7A TUBA1A
2 nervous system MP:0003631 9.23 CHN1 DMRTA2 KIF21A NAP1L2 PHOX2A SEMA7A

Drugs & Therapeutics for Paralytic Squint

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Age at Time of Surgery on the Surgical Outcome After Bilateral Lateral Rectus Muscle Recession in Intermittent Exotropia Not yet recruiting NCT04307160

Search NIH Clinical Center for Paralytic Squint

Genetic Tests for Paralytic Squint

Anatomical Context for Paralytic Squint

MalaCards organs/tissues related to Paralytic Squint:

40
Eye, Testes, Thyroid

Publications for Paralytic Squint

Articles related to Paralytic Squint:

(show top 50) (show all 190)
# Title Authors PMID Year
1
NGF and CNTF expression and regulation mechanism by miRNA in acute paralytic strabismus. 61
31925656 2020
2
Flavonoids Sophoranone Promotes Differentiation of C2C12 and Extraocular Muscle Satellite Cells. 61
32344402 2020
3
Prevalence of Strabismus and Its Impact on Vision-Related Quality of Life: Results from the German Population-Based Gutenberg Health Study. 61
32312635 2020
4
Clinical efficacy of the partial rectus muscle transportation procedure for paralytic strabismus. 61
32566512 2020
5
Acquired Ocular Motor Palsy: Current Demographic and Etiological Profile. 61
31990742 2020
6
Acquired Ocular Motor Palsy: Current Demographic and Etiological Profile. 61
31977330 2020
7
A case of linear scleroderma "en coup de sabre" with strabismus fixus in a child. 61
31544571 2019
8
The Management of Childhood Intracranial Tumours and the Role of the Ophthalmologist. 61
32165896 2019
9
Strabismus Is Correlated with Gross Motor Function in Children with Spastic Cerebral Palsy. 61
31189336 2019
10
Inflammatory optic neuropathy in granulomatosis with polyangiitis can mimick isolated idiopathic optic neuritis. 61
31744325 2019
11
Don't Miss This! Red Flags in the Pediatric Eye Examination: Ophthalmoplegia in Childhood. 61
31329057 2019
12
Ophthalmologic Clinical Features of Facial Nerve Palsy Patients. 61
30746906 2019
13
Clinical Course and Prognostic Factors of Acquired Third, Fourth, and Sixth Cranial Nerve Palsy in Korean Patients. 61
29770635 2018
14
MRI findings of contralateral oculomotor nerve palsy in Parry-Romberg syndrome. 61
29780922 2018
15
Ocular motor cranial nerve palsy and increased risk of stroke in the general population. 61
30321220 2018
16
Ocular congenital cranial dysinnervation disorders (CCDDs): insights into axon growth and guidance. 61
28459979 2017
17
Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study. 61
28356250 2017
18
Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome. 61
28346224 2017
19
Changing Strabismus Surgery Distribution at Shanxi Province Eye Hospital in Central China. 61
27977036 2017
20
Early Onset Sixth-Nerve Palsy with Eccentric Fixation. 61
28904218 2017
21
Two unique TUBB3 mutations cause both CFEOM3 and malformations of cortical development. 61
26639658 2016
22
Ocular Complications in Children with Diabetes Mellitus. 61
26341461 2015
23
The Role of Extraocular Muscle Pulleys in Incomitant Non-Paralytic Strabismus. 61
26180464 2015
24
Periosteal Fixation Procedures in the Management of Incomitant Strabismus. 61
26180470 2015
25
Muscle Union Procedure in Patients with Paralytic Strabismus. 61
26070148 2015
26
[Strabismus Sursoabductorius (put into the Context of eighteen Years of Strabismus Surgery Analysis)]. 61
26782915 2015
27
Paralytic strabismus and papilloedema caused by dural sinus thrombosis after bee sting. 61
25234425 2015
28
Incidence, types, and lifetime risk of adult-onset strabismus. 61
24321142 2014
29
Treatment of consecutive exotropia: unilateral lateral rectus recession combined with medial rectus advancement or resection. 61
24512646 2014
30
Strabismus surgery distribution during 10-year period in a tertiary hospital. 61
25131226 2014
31
[Partial rectus muscle transposition for strabismus with lateral rectus muscles paralysis]. 61
24257354 2013
32
Acquired paralytic strabismus in Southern Taiwan. 61
23608076 2013
33
Effectivity of intraoperative adjustable suture technique in horizontal strabismus. 61
23991385 2013
34
Strabismus among aged fee-for-service Medicare beneficiaries. 61
23158551 2012
35
Paralytic strabismus in South African Black and mixed race children--a 15-year clinic-based review. 61
23171209 2012
36
[Faden operations - indications beyond esotropia and surgical results]. 61
22826188 2012
37
A 6-year-old girl with restricted upward gaze of her right eye. 61
22855935 2012
38
Paralytic squint due to abducens nerve palsy: a rare consequence of dengue fever. 61
22799448 2012
39
Imaging of torticollis in children. 61
22411949 2012
40
Paralytic strabismus: third, fourth, and sixth nerve palsy. 61
20638001 2010
41
A 4 year retrospective survey of strabismus surgery in Tongren Eye Centre Beijing. 61
20444139 2010
42
[Study on acupuncture for treatment of oculomotor paralysis according to syndrome differentiation of meridians]. 61
20214071 2010
43
[Clinical observation on acupuncture for treatment of paralytic strabismus]. 61
19873915 2009
44
Exotropia caused by pit viper snakebite. 61
19683199 2009
45
Minimally invasive strabismus surgery (MISS) for rectus muscle transpositions. 61
19211600 2009
46
Five cases of paralytic strabismus as a rare feature of lyme disease. 61
19193112 2009
47
[Central nervous system abnormalities related to congenital fibrosis of extraocular muscles]. 61
19228463 2009
48
Behavioural and electrophysiological analysis of strabismus in cats: modern context. 61
18618102 2009
49
Rectus muscle posterior tenon fixation as an inactivation procedure. 61
18538301 2008
50
[Observation on therapeutic effect of acupuncture combined with western medicine on paralytic strabismus]. 61
18630533 2008

Variations for Paralytic Squint

Expression for Paralytic Squint

Search GEO for disease gene expression data for Paralytic Squint.

Pathways for Paralytic Squint

GO Terms for Paralytic Squint

Cellular components related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule GO:0005874 8.8 TUBB2B TUBA1A KIF21A

Biological processes related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.26 TUBB2B SEMA7A PHOX2A CHN1
2 microtubule-based process GO:0007017 9.16 TUBB2B TUBA1A
3 dopaminergic neuron differentiation GO:0071542 8.62 PHOX2A DMRTA2

Sources for Paralytic Squint

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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