MCID: PRL014
MIFTS: 29

Paralytic Squint

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Paralytic Squint

MalaCards integrated aliases for Paralytic Squint:

Name: Paralytic Squint 12 15
Paralytic Strabismus 12 17 71 32
Incomitant Dissociation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10863
ICD9CM 34 378.5 378.50
SNOMED-CT 67 12942001
ICD10 32 H49 H49.9
UMLS 71 C0152221

Summaries for Paralytic Squint

MalaCards based summary : Paralytic Squint, also known as paralytic strabismus, is related to abducens nerve disease and ptosis. An important gene associated with Paralytic Squint is KIF21A (Kinesin Family Member 21A). Affiliated tissues include eye, testes and thyroid, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Strabismus is a condition in which the eyes do not properly align with each other when looking at an... more...

Related Diseases for Paralytic Squint

Diseases related to Paralytic Squint via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 abducens nerve disease 31.5 NT5C3A CHN1
2 ptosis 30.4 PHOX2A NT5C3A KIF21A
3 suppression amblyopia 29.7 PLAAT3 PHOX2A MTRNR2L5
4 amblyopia 29.6 PLAAT3 PHOX2A KIF21A CHN1
5 tukel syndrome 29.2 TUBB2B TUBA1A PHOX2A NT5C3A KIF21A CHN1
6 exotropia 29.1 SEMA7A PLAAT3 PHOX2A NT5C3A KIF21A CHN1
7 esotropia 28.5 TUBB2B SEMA7A PLAAT3 PHOX2A NT5C3A KIF21A
8 strabismus 28.5 TUBB2B SEMA7A PLAAT3 PHOX2A NT5C3A KIF21A
9 kearns-sayre syndrome 10.6
10 tolosa-hunt syndrome 10.5
11 cranial nerve palsy 10.4
12 fourth cranial nerve palsy, familial congenital 10.4
13 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 1 10.4
14 fourth cranial nerve palsy 10.4
15 oculomotor nerve paralysis 10.4
16 chronic progressive external ophthalmoplegia 10.4
17 trochlear nerve disease 10.4
18 horizontal gaze palsy with progressive scoliosis 10.4
19 autosomal dominant progressive external ophthalmoplegia 10.4
20 mitochondrial dna-related progressive external ophthalmoplegia 10.4
21 congenital trochlear nerve palsy 10.4
22 marcus gunn phenomenon 10.3 PHOX2A KIF21A
23 alternating exotropia 10.2
24 myotonic cataract 10.2 PHOX2A KIF21A
25 fibrosis of extraocular muscles, congenital, 2 10.2 PHOX2A KIF21A
26 lyme disease 10.2
27 myopia 10.2
28 cauda equina syndrome 10.1
29 mononeuropathy 10.1
30 dengue disease 10.1
31 dengue hemorrhagic fever 10.1
32 guillain-barre syndrome 10.1
33 optic nerve disease 10.1
34 myelitis 10.1
35 polyradiculopathy 10.1
36 transverse myelitis 10.1
37 monocular esotropia 10.1
38 mechanical strabismus 10.1
39 enophthalmos 10.1 PHOX2A NT5C3A
40 microphthalmia, isolated 5 10.0 TUBB2B PHOX2A KIF21A
41 ametropic amblyopia 10.0 PHOX2A MTRNR2L5
42 duane-radial ray syndrome 10.0 PHOX2A KIF21A CHN1
43 abducens palsy 10.0
44 marfan syndrome 10.0
45 ocular dominance 10.0
46 myasthenia gravis 10.0
47 thrombosis 10.0
48 vascular disease 10.0
49 keratopathy 10.0
50 craniosynostosis 10.0

Graphical network of the top 20 diseases related to Paralytic Squint:



Diseases related to Paralytic Squint

Symptoms & Phenotypes for Paralytic Squint

GenomeRNAi Phenotypes related to Paralytic Squint according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.36 PHOX2A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.36 TUBA1A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.36 TUBA1A
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.36 NT5C3A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.36 TUBA1A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.36 PHOX2A
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.36 PHOX2A
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.36 TUBA1A
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.36 NT5C3A PHOX2A TUBA1A

MGI Mouse Phenotypes related to Paralytic Squint:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.5 CHN1 KIF21A PHOX2A PLAAT3 SEMA7A TUBA1A
2 nervous system MP:0003631 9.17 CHN1 KIF21A NAP1L2 PHOX2A SEMA7A TUBA1A

Drugs & Therapeutics for Paralytic Squint

Search Clinical Trials , NIH Clinical Center for Paralytic Squint

Genetic Tests for Paralytic Squint

Anatomical Context for Paralytic Squint

MalaCards organs/tissues related to Paralytic Squint:

40
Eye, Testes, Thyroid

Publications for Paralytic Squint

Articles related to Paralytic Squint:

(show top 50) (show all 183)
# Title Authors PMID Year
1
A case of linear scleroderma "en coup de sabre" with strabismus fixus in a child. 61
31544571 2019
2
Strabismus Is Correlated with Gross Motor Function in Children with Spastic Cerebral Palsy. 61
31189336 2019
3
Inflammatory optic neuropathy in granulomatosis with polyangiitis can mimick isolated idiopathic optic neuritis. 61
31744325 2019
4
Don't Miss This! Red Flags in the Pediatric Eye Examination: Ophthalmoplegia in Childhood. 61
31329057 2019
5
Ophthalmologic Clinical Features of Facial Nerve Palsy Patients. 61
30746906 2019
6
Clinical Course and Prognostic Factors of Acquired Third, Fourth, and Sixth Cranial Nerve Palsy in Korean Patients. 61
29770635 2018
7
MRI findings of contralateral oculomotor nerve palsy in Parry-Romberg syndrome. 61
29780922 2018
8
Ocular motor cranial nerve palsy and increased risk of stroke in the general population. 61
30321220 2018
9
Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study. 61
28356250 2017
10
Ocular congenital cranial dysinnervation disorders (CCDDs): insights into axon growth and guidance. 61
28459979 2017
11
Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome. 61
28346224 2017
12
Changing Strabismus Surgery Distribution at Shanxi Province Eye Hospital in Central China. 61
27977036 2017
13
Early Onset Sixth-Nerve Palsy with Eccentric Fixation. 61
28904218 2017
14
Two unique TUBB3 mutations cause both CFEOM3 and malformations of cortical development. 61
26639658 2016
15
Ocular Complications in Children with Diabetes Mellitus. 61
26341461 2015
16
The Role of Extraocular Muscle Pulleys in Incomitant Non-Paralytic Strabismus. 61
26180464 2015
17
Periosteal Fixation Procedures in the Management of Incomitant Strabismus. 61
26180470 2015
18
[Strabismus Sursoabductorius (put into the Context of eighteen Years of Strabismus Surgery Analysis)]. 61
26782915 2015
19
Muscle Union Procedure in Patients with Paralytic Strabismus. 61
26070148 2015
20
Paralytic strabismus and papilloedema caused by dural sinus thrombosis after bee sting. 61
25234425 2015
21
Incidence, types, and lifetime risk of adult-onset strabismus. 61
24321142 2014
22
Treatment of consecutive exotropia: unilateral lateral rectus recession combined with medial rectus advancement or resection. 61
24512646 2014
23
Strabismus surgery distribution during 10-year period in a tertiary hospital. 61
25131226 2014
24
[Partial rectus muscle transposition for strabismus with lateral rectus muscles paralysis]. 61
24257354 2013
25
Acquired paralytic strabismus in Southern Taiwan. 61
23608076 2013
26
Effectivity of intraoperative adjustable suture technique in horizontal strabismus. 61
23991385 2013
27
Strabismus among aged fee-for-service Medicare beneficiaries. 61
23158551 2012
28
Paralytic strabismus in South African Black and mixed race children--a 15-year clinic-based review. 61
23171209 2012
29
[Faden operations - indications beyond esotropia and surgical results]. 61
22826188 2012
30
A 6-year-old girl with restricted upward gaze of her right eye. 61
22855935 2012
31
Paralytic squint due to abducens nerve palsy: a rare consequence of dengue fever. 61
22799448 2012
32
Imaging of torticollis in children. 61
22411949 2012
33
Paralytic strabismus: third, fourth, and sixth nerve palsy. 61
20638001 2010
34
A 4 year retrospective survey of strabismus surgery in Tongren Eye Centre Beijing. 61
20444139 2010
35
[Study on acupuncture for treatment of oculomotor paralysis according to syndrome differentiation of meridians]. 61
20214071 2010
36
[Clinical observation on acupuncture for treatment of paralytic strabismus]. 61
19873915 2009
37
Exotropia caused by pit viper snakebite. 61
19683199 2009
38
Minimally invasive strabismus surgery (MISS) for rectus muscle transpositions. 61
19211600 2009
39
Five cases of paralytic strabismus as a rare feature of lyme disease. 61
19193112 2009
40
[Central nervous system abnormalities related to congenital fibrosis of extraocular muscles]. 61
19228463 2009
41
Behavioural and electrophysiological analysis of strabismus in cats: modern context. 61
18618102 2009
42
Rectus muscle posterior tenon fixation as an inactivation procedure. 61
18538301 2008
43
[Observation on therapeutic effect of acupuncture combined with western medicine on paralytic strabismus]. 61
18630533 2008
44
[Randomized controlled study on acupuncture for treatment of diabetic paralytic squint]. 61
18405147 2008
45
General principles in the surgical treatment of paralytic strabismus. 61
21149177 2008
46
Ocular involvement in children with localised scleroderma: a multi-centre study. 61
17475707 2007
47
[Paralytic strabismus: review of 24 years at "Santa Casa de São Paulo"]. 61
17906751 2007
48
[Therapeutic options in III. nerve paralysis]. 61
17605267 2007
49
[The application of botulinum toxin A in the treatment of restrictive strabismus in thyroid associated ophthalmopathy]. 61
17415961 2006
50
Filamentary keratopathy caused by corneal occlusion by large-angle paralytic strabismus. 61
17133065 2006

Variations for Paralytic Squint

Expression for Paralytic Squint

Search GEO for disease gene expression data for Paralytic Squint.

Pathways for Paralytic Squint

GO Terms for Paralytic Squint

Cellular components related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule GO:0005874 8.8 TUBB2B TUBA1A KIF21A

Biological processes related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule-based process GO:0007017 8.96 TUBB2B TUBA1A
2 nervous system development GO:0007399 8.92 TUBB2B SEMA7A PHOX2A CHN1

Sources for Paralytic Squint

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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