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MCID: PRM208
MIFTS: 25

Parameningeal Embryonal Rhabdomyosarcoma

Categories: Cancer diseases, Fetal diseases, Muscle diseases
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Aliases & Classifications for Parameningeal Embryonal Rhabdomyosarcoma

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MalaCards integrated aliases for Parameningeal Embryonal Rhabdomyosarcoma:

Name: Parameningeal Embryonal Rhabdomyosarcoma 11 14

Classifications:

MalaCards categories:
Global: Cancer diseases Fetal diseases
Anatomical: Muscle diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:0060338
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Summaries for Parameningeal Embryonal Rhabdomyosarcoma

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Disease Ontology: 11 An embryonal rhabdomyosarcoma located in the parameningeal region.

MalaCards based summary: Parameningeal Embryonal Rhabdomyosarcoma is related to embryonal rhabdomyosarcoma and rhabdomyosarcoma. An important gene associated with Parameningeal Embryonal Rhabdomyosarcoma is GLI4 (GLI Family Zinc Finger 4), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Related phenotypes are homeostasis/metabolism and growth/size/body region
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Related Diseases for Parameningeal Embryonal Rhabdomyosarcoma

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Diseases related to Parameningeal Embryonal Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 embryonal rhabdomyosarcoma 29.7 TP53 RHD PAX7 PAX3 MYOG FOXO1
2 rhabdomyosarcoma 29.5 TP53 PAX7 PAX3 NRAS MYOG FOXO1
3 central nervous system rhabdomyosarcoma 10.2 PAX3 FOXO1
4 oral rhabdomyosarcoma 10.2 PAX3 MYOG
5 skeletal muscle neoplasm 10.2 RHD MYOG
6 botryoid rhabdomyosarcoma 10.2 PAX3 MYOG
7 prostate embryonal rhabdomyosarcoma 10.2 PAX3 MYOG
8 adult fibrosarcoma 10.2 PAX3 MYOG
9 hydrocephalus 10.2
10 sarcoma 10.2
11 bell's palsy 10.2
12 acoustic neuroma 10.2
13 facial paralysis 10.2
14 neurilemmoma 10.2
15 cranial nerve palsy 10.2
16 conventional leiomyosarcoma 10.2 PAX7 MYOG
17 inflammatory leiomyosarcoma 10.1 PAX7 MYOG
18 central nervous system mesenchymal non-meningothelial tumor 10.1 PAX7 PAX3 MYOG
19 ectomesenchymoma 10.1 PAX7 PAX3 MYOG
20 spindle cell rhabdomyosarcoma 10.1 PAX7 PAX3 MYOG
21 desmoplastic small round cell tumor 10.1 PAX7 PAX3 MYOG
22 micronodular basal cell carcinoma 10.0 TP53 NRAS
23 breast sarcoma 10.0 TP53 MYOG
24 large cell carcinoma with rhabdoid phenotype 10.0 TP53 MYOG
25 cervical adenosarcoma 10.0 TP53 MYOG
26 malignant spindle cell melanoma 9.9 TP53 NRAS
27 vaginal carcinosarcoma 9.9 TP53 FBXW7
28 breast rhabdomyosarcoma 9.9 PAX7 PAX3 MYOG FOXO1
29 basal cell nevus syndrome 9.9 TP53 PAX7 PAX3
30 myxoid liposarcoma 9.9 TP53 PAX3 FOXO1
31 la crosse encephalitis 9.9 GAS6 AXL
32 adult malignant schwannoma 9.9 TP53 MYOG
33 well-differentiated liposarcoma 9.9 TP53 PAX3 MYOG
34 spindle cell sarcoma 9.9 TP53 PAX3 MYOG
35 conjunctival cancer 9.9 TP53 NRAS
36 myxofibrosarcoma 9.9 TP53 PAX3 MYOG
37 dedifferentiated liposarcoma 9.9 TP53 PAX3 MYOG
38 nodular malignant melanoma 9.9 TP53 NRAS
39 anal squamous cell carcinoma 9.9 TP53 FBXW7
40 carey-fineman-ziter syndrome 1 9.8 PAX7 MYOG
41 rectum adenocarcinoma 9.8 TP53 NRAS FBXW7
42 giant cell glioblastoma 9.8 TP53 NRAS FBXW7
43 progressive relapsing multiple sclerosis 9.8 RHD PAX7 PAX3 MYOG FOXO1
44 ovarian serous cystadenocarcinoma 9.8 TP53 NRAS FBXW7
45 aging 9.8 TP53 NAMPT FOXO1
46 clear cell basal cell carcinoma 9.8 TP53 PAX7 PAX3 MYOG
47 pleomorphic liposarcoma 9.8 TP53 MYOG
48 orbit embryonal rhabdomyosarcoma 9.7 PAX7 PAX3 MYOG FOXO1 FGFR4
49 skin melanoma 9.7 TP53 NRAS FBXW7
50 bladder urothelial carcinoma 9.7 TP53 NRAS FBXW7

Graphical network of the top 20 diseases related to Parameningeal Embryonal Rhabdomyosarcoma:



Diseases related to Parameningeal Embryonal Rhabdomyosarcoma
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Symptoms & Phenotypes for Parameningeal Embryonal Rhabdomyosarcoma

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GenomeRNAi Phenotypes related to Parameningeal Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.13 ARHGEF25 AXL CDC42 EIF5B FBXW7 FGFR4
2 no effect GR00402-S-2 10.13 ARHGEF25 AXL CDC42 FBXW7 FGFR4 FOXO1

MGI Mouse Phenotypes related to Parameningeal Embryonal Rhabdomyosarcoma:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 AXL CDC42 FBXW7 FGFR4 FOXO1 GAS6
2 growth/size/body region MP:0005378 10.29 AXL CDC42 FBXW7 FGFR4 FOXO1 GAS6
3 normal MP:0002873 10.26 ARHGEF25 AXL CDC42 FBXW7 FOXO1 MYOG
4 cellular MP:0005384 10.22 AXL CDC42 FBXW7 FGFR4 FOXO1 GAS6
5 endocrine/exocrine gland MP:0005379 10.15 AXL CDC42 FBXW7 FOXO1 NAMPT NRAS
6 embryo MP:0005380 10.13 CDC42 FBXW7 FOXO1 MYOG NRAS PAX3
7 neoplasm MP:0002006 10.11 FBXW7 FGFR4 FOXO1 NRAS PAX3 PAX7
8 muscle MP:0005369 10.09 CDC42 FOXO1 MYOG PAX3 PAX7 TP53
9 cardiovascular system MP:0005385 10.07 ARHGEF25 AXL CDC42 FBXW7 FOXO1 GAS6
10 digestive/alimentary MP:0005381 10.06 CDC42 FBXW7 FOXO1 NRAS PAX3 PAX7
11 craniofacial MP:0005382 10.03 CDC42 FBXW7 FOXO1 NRAS PAX3 PAX7
12 limbs/digits/tail MP:0005371 10.01 CDC42 FOXO1 NRAS PAX3 TP53 VCL
13 vision/eye MP:0005391 9.91 AXL CDC42 FBXW7 GAS6 NAMPT NRAS
14 hematopoietic system MP:0005397 9.9 AXL CDC42 FBXW7 FGFR4 FOXO1 GAS6
15 respiratory system MP:0005388 9.87 CDC42 FBXW7 FGFR4 MYOG PAX3 PAX7
16 mortality/aging MP:0010768 9.83 ARHGEF25 AXL CDC42 EIF5B FBXW7 FGFR4
17 integument MP:0010771 9.28 AXL CDC42 FBXW7 FOXO1 MYOG NRAS
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Drugs & Therapeutics for Parameningeal Embryonal Rhabdomyosarcoma

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Search Clinical Trials, NIH Clinical Center for Parameningeal Embryonal Rhabdomyosarcoma

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Genetic Tests for Parameningeal Embryonal Rhabdomyosarcoma

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Anatomical Context for Parameningeal Embryonal Rhabdomyosarcoma

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Publications for Parameningeal Embryonal Rhabdomyosarcoma

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Articles related to Parameningeal Embryonal Rhabdomyosarcoma:

# Title Authors PMID Year
1
A rare presentation of a bilateral intracranial parameningeal embryonal rhabdomyosarcoma mimicking vestibular schwannoma in a two-year-old child: a case report. 62
36355193 2022
2
A Patient-Derived Xenograft Model of Parameningeal Embryonal Rhabdomyosarcoma for Preclinical Studies. 62
26696773 2015
3
Congenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infant. 62
16283194 2006
4
Ophthalmic involvement as a presenting feature of nonorbital childhood parameningeal embryonal rhabdomyosarcoma. 62
11150285 2001
5
Parameningeal embryonal rhabdomyosarcoma in an adult. 62
11225232 1999
6
Acute renal failure in high dose carboplatin chemotherapy. 62
7565311 1995
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Variations for Parameningeal Embryonal Rhabdomyosarcoma

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Expression for Parameningeal Embryonal Rhabdomyosarcoma

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Search GEO for disease gene expression data for Parameningeal Embryonal Rhabdomyosarcoma.
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Pathways for Parameningeal Embryonal Rhabdomyosarcoma

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Pathways related to Parameningeal Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.57 AXL CDC42 FGFR4 FOXO1 GAS6 NRAS
2
GPCR Pathway 64
Show member pathways
 13.51 VCL TP53 NRAS GAS6 FGFR4 CDC42
3
RAF/MAP kinase cascade 66
Show member pathways
 13.17 CDC42 FBXW7 FGFR4 FOXO1 NRAS VCL
4
Signal Transduction 66
13.02 VCL TP53 NRAS FOXO1 FGFR4 FBXW7
5
Akt Signaling 64
Show member pathways
 13.01 AXL CDC42 FGFR4 FOXO1 GAS6 NRAS
6
Phospholipase-C Pathway 64
Show member pathways
 12.85 TP53 NRAS GAS6 FGFR4 CDC42
7
Endometrial cancer 74
Show member pathways
 12.51 VCL TP53 NRAS CDC42
8
MAPK signaling pathway 74
12.06 TP53 NRAS FGFR4 CDC42
9
Integrated breast cancer pathway 74
11.95 TP53 FOXO1 CDC42
10
Tyrosine Kinases / Adaptors 3
11.92 GAS6 FGFR4 AXL
11
MAPK Signaling: Mitogens 65
Show member pathways
 11.92 TP53 NRAS FOXO1 FGFR4
12
22q11.2 copy number variation syndrome 74
11.84 TP53 PAX3 CDC42
13
G-protein signaling RAC1 in cellular process 22
Show member pathways
 11.84 NRAS GAS6 FGFR4 CDC42 AXL
14
Ebola virus infection in host 74
11.82 GAS6 CDC42 AXL
15
DNA damage response (only ATM dependent) 74
11.69 TP53 NRAS CDC42
16
Mesenchymal Stem Cells and Lineage-specific Markers 65
11.63 PAX7 PAX3 MYOG
17
Pathways affected in adenoid cystic carcinoma 74
11.23 TP53 FGFR4 FBXW7
18
Regulation of actin cytoskeleton 74
11.1 VCL NRAS FGFR4 CDC42
19
NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence 74
10.75 TP53 NAMPT
20
NAD metabolism, sirtuins and aging 74
10.5 NAMPT FOXO1
21
Caloric restriction and aging 74
10.36 TP53 NAMPT
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GO Terms for Parameningeal Embryonal Rhabdomyosarcoma

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Biological processes related to Parameningeal Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anatomical structure development GO:0048856 9.8 PAX7 PAX3 MYOG
2 cellular response to interferon-alpha GO:0035457 9.67 GAS6 AXL
3 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.62 GAS6 AXL
4 negative regulation of dendritic cell apoptotic process GO:2000669 9.56 GAS6 AXL
5 positive regulation of natural killer cell differentiation GO:0032825 9.46 GAS6 AXL
6 enzyme-linked receptor protein signaling pathway GO:0007167 9.13 GAS6 AXL
7 positive regulation of pinocytosis GO:0048549 8.92 CDC42 AXL
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Sources for Parameningeal Embryonal Rhabdomyosarcoma

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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