MCID: PRM208
MIFTS: 30

Parameningeal Embryonal Rhabdomyosarcoma

Categories: Cancer diseases, Fetal diseases, Muscle diseases

Aliases & Classifications for Parameningeal Embryonal Rhabdomyosarcoma

MalaCards integrated aliases for Parameningeal Embryonal Rhabdomyosarcoma:

Name: Parameningeal Embryonal Rhabdomyosarcoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060338

Summaries for Parameningeal Embryonal Rhabdomyosarcoma

Disease Ontology : 12 An embryonal rhabdomyosarcoma located in the parameningeal region.

MalaCards based summary : Parameningeal Embryonal Rhabdomyosarcoma is related to embryonal rhabdomyosarcoma and rhabdomyosarcoma. An important gene associated with Parameningeal Embryonal Rhabdomyosarcoma is GLI4 (GLI Family Zinc Finger 4), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Human cytomegalovirus infection. Affiliated tissues include thyroid, breast and bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Parameningeal Embryonal Rhabdomyosarcoma

Diseases related to Parameningeal Embryonal Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 embryonal rhabdomyosarcoma 28.4 TP53 PAX7 PAX3 MYOG MDM2 FOXO1
2 rhabdomyosarcoma 27.5 TP53 PAX7 PAX3 MYOG MDM2 FOXO1
3 conventional leiomyosarcoma 10.4 PAX7 MYOG
4 orbit rhabdomyosarcoma 10.4 PAX3 MYOG
5 splenic diffuse red pulp small b-cell lymphoma 10.4 TP53 BCOR
6 botryoid rhabdomyosarcoma 10.3 PAX3 MYOG
7 central nervous system rhabdomyosarcoma 10.3 PAX3 FOXO1
8 central nervous system mesenchymal non-meningothelial tumor 10.2 PAX7 PAX3 MYOG
9 spindle cell rhabdomyosarcoma 10.2 PAX7 PAX3 MYOG
10 yemenite deaf-blind hypopigmentation syndrome 10.2
11 cranial nerve palsy 10.2
12 dacryocystocele 10.2 PAX3 KIDINS220
13 heart lymphoma 10.2 MYOG ALK
14 chronic inflammation of lacrimal passage 10.2 PAX3 KIDINS220
15 ectomesenchymoma 10.2 MYOG FOXO1
16 micronodular basal cell carcinoma 10.2 TP53 NRAS
17 rare head and neck tumor 10.2 TP53 PIK3CA
18 adult malignant schwannoma 10.2 TP53 MYOG
19 breast squamous cell carcinoma 10.1 TP53 PIK3CA
20 sarcomatoid transitional cell carcinoma 10.1 TP53 ALK
21 facioscapulohumeral muscular dystrophy 1 10.1 PAX7 PAX3 MYOG
22 rare adenocarcinoma of the breast 10.1 TP53 PIK3CA
23 basal cell nevus syndrome 10.1 TP53 PAX7 PAX3
24 heart sarcoma 10.1 MYOG MDM2
25 prostate embryonal rhabdomyosarcoma 10.1 PAX3 MYOG FOXO1
26 actinic cheilitis 10.1 TP53 MDM2
27 mesenchymoma 10.1 MYOG MDM2
28 pediatric fibrosarcoma 10.1 MYOG BCOR ALK
29 malignant mesenchymoma 10.1 MYOG MDM2
30 esophagus verrucous carcinoma 10.1 TP53 MDM2
31 bone giant cell sarcoma 10.0 TP53 MDM2
32 maxillary sinus adenocarcinoma 10.0 TP53 MDM2
33 breast sarcoma 10.0 TP53 PIK3CA
34 ovarian carcinosarcoma 10.0 TP53 PIK3CA
35 thyroid gland anaplastic carcinoma 10.0 TP53 PIK3CA
36 vulva squamous cell carcinoma 10.0 TP53 PIK3CA
37 adenosquamous lung carcinoma 10.0 PIK3CA ALK
38 inflammatory liposarcoma 10.0 MDM2 ALK
39 clear cell basal cell carcinoma 9.9 TP53 PAX7 PAX3 MYOG
40 mesenchymal cell neoplasm 9.9 TP53 MYOG ALK
41 mixed cell type cancer 9.9 TP53 PIK3CA MYOG
42 uterine corpus serous adenocarcinoma 9.9 TP53 PIK3CA FBXW7
43 uterine body mixed cancer 9.9 TP53 PIK3CA FBXW7
44 uterine corpus cancer 9.9 TP53 PIK3CA FBXW7
45 synovium cancer 9.9 PAX3 MYOG FOXO1 BCOR
46 endometrioid ovary carcinoma 9.9 TP53 PIK3CA
47 gliomatosis cerebri 9.9 TP53 MDM2 FGFR4
48 vulvar disease 9.9 TP53 PIK3CA NRAS
49 adrenocortical carcinoma, hereditary 9.9 TP53 PIK3CA NRAS
50 thyroid tumor 9.9 TP53 PIK3CA NRAS

Graphical network of the top 20 diseases related to Parameningeal Embryonal Rhabdomyosarcoma:



Diseases related to Parameningeal Embryonal Rhabdomyosarcoma

Symptoms & Phenotypes for Parameningeal Embryonal Rhabdomyosarcoma

GenomeRNAi Phenotypes related to Parameningeal Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.91 PIK3CA
2 Decreased viability GR00221-A-1 9.91 ALK FOXO1 KIDINS220 NRAS PIK3CA
3 Decreased viability GR00221-A-2 9.91 FOXO1 PIK3CA
4 Decreased viability GR00221-A-3 9.91 FOXO1 NRAS
5 Decreased viability GR00221-A-4 9.91 ALK KIDINS220 PIK3CA
6 Decreased viability GR00381-A-1 9.91 KIDINS220
7 Decreased viability GR00402-S-2 9.91 ALK FOXO1 NRAS PIK3CA
8 Increased cell death HMECs cells GR00103-A-0 9.02 FBXW7 FGFR4 MDM2 PIK3CA TP53

MGI Mouse Phenotypes related to Parameningeal Embryonal Rhabdomyosarcoma:

45 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.41 BCOR CDK4 FBXW7 FGFR4 FOXO1 KIDINS220
2 growth/size/body region MP:0005378 10.4 ALK BCOR CDK4 FBXW7 FGFR4 FOXO1
3 behavior/neurological MP:0005386 10.35 ALK CDK4 FGFR4 FOXO1 MDM2 MYOG
4 embryo MP:0005380 10.32 BCOR CDK4 FBXW7 FOXO1 MDM2 MYOG
5 mortality/aging MP:0010768 10.32 ALK BCOR CDK4 FBXW7 FGFR4 FOXO1
6 homeostasis/metabolism MP:0005376 10.31 ALK CDK4 FBXW7 FGFR4 FOXO1 MDM2
7 cardiovascular system MP:0005385 10.3 BCOR CDK4 FBXW7 FOXO1 KIDINS220 MDM2
8 endocrine/exocrine gland MP:0005379 10.27 ALK CDK4 FBXW7 FOXO1 MDM2 NRAS
9 immune system MP:0005387 10.26 BCOR CDK4 FBXW7 FGFR4 FOXO1 MDM2
10 hematopoietic system MP:0005397 10.25 BCOR CDK4 FBXW7 FGFR4 FOXO1 MDM2
11 integument MP:0010771 10.25 ALK CDK4 FBXW7 FOXO1 MDM2 MYOG
12 craniofacial MP:0005382 10.19 CDK4 FBXW7 FOXO1 MDM2 NRAS PAX3
13 digestive/alimentary MP:0005381 10.19 CDK4 FBXW7 FOXO1 MDM2 NRAS PAX3
14 neoplasm MP:0002006 10.17 ALK CDK4 FBXW7 FGFR4 FOXO1 MDM2
15 nervous system MP:0003631 10.14 ALK BCOR CDK4 FBXW7 FOXO1 KIDINS220
16 muscle MP:0005369 10.06 CDK4 FOXO1 MDM2 MYOG PAX3 PAX7
17 liver/biliary system MP:0005370 10.04 CDK4 FBXW7 FOXO1 MDM2 NRAS PAX3
18 no phenotypic analysis MP:0003012 10.02 FOXO1 KIDINS220 MDM2 MYOG NRAS PAX3
19 normal MP:0002873 9.97 CDK4 FBXW7 FOXO1 MDM2 MYOG NRAS
20 pigmentation MP:0001186 9.73 ALK CDK4 MDM2 NRAS PAX3 TP53
21 respiratory system MP:0005388 9.7 ALK FBXW7 FGFR4 MYOG PAX3 PAX7
22 skeleton MP:0005390 9.7 ALK CDK4 FGFR4 FOXO1 MDM2 MYOG
23 vision/eye MP:0005391 9.28 ALK CDK4 FBXW7 KIDINS220 NRAS PAX3

Drugs & Therapeutics for Parameningeal Embryonal Rhabdomyosarcoma

Search Clinical Trials , NIH Clinical Center for Parameningeal Embryonal Rhabdomyosarcoma

Genetic Tests for Parameningeal Embryonal Rhabdomyosarcoma

Anatomical Context for Parameningeal Embryonal Rhabdomyosarcoma

MalaCards organs/tissues related to Parameningeal Embryonal Rhabdomyosarcoma:

40
Thyroid, Breast, Bone, Heart, Lung, B Cells, Ovary

Publications for Parameningeal Embryonal Rhabdomyosarcoma

Articles related to Parameningeal Embryonal Rhabdomyosarcoma:

# Title Authors PMID Year
1
A Patient-Derived Xenograft Model of Parameningeal Embryonal Rhabdomyosarcoma for Preclinical Studies. 61
26696773 2015
2
Congenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infant. 61
16283194 2006
3
Ophthalmic involvement as a presenting feature of nonorbital childhood parameningeal embryonal rhabdomyosarcoma. 61
11150285 2001
4
Parameningeal embryonal rhabdomyosarcoma in an adult. 61
11225232 1999
5
Acute renal failure in high dose carboplatin chemotherapy. 61
7565311 1995

Variations for Parameningeal Embryonal Rhabdomyosarcoma

Expression for Parameningeal Embryonal Rhabdomyosarcoma

Search GEO for disease gene expression data for Parameningeal Embryonal Rhabdomyosarcoma.

Pathways for Parameningeal Embryonal Rhabdomyosarcoma

Pathways related to Parameningeal Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.37 TP53 PIK3CA NRAS MDM2 FOXO1 FGFR4
2
Show member pathways
12.86 TP53 PIK3CA NRAS MDM2 CDK4
3
Show member pathways
12.84 TP53 PIK3CA NRAS MDM2 FOXO1 FGFR4
4
Show member pathways
12.78 TP53 PIK3CA NRAS MDM2 FOXO1 CDK4
5
Show member pathways
12.64 TP53 PIK3CA NRAS MDM2 FOXO1 FGFR4
6
Show member pathways
12.55 TP53 PIK3CA NRAS MDM2 FOXO1
7
Show member pathways
12.53 PIK3CA NRAS CDK4 ALK
8
Show member pathways
12.52 TP53 PIK3CA NRAS FOXO1
9 12.47 TP53 PIK3CA NRAS MDM2
10
Show member pathways
12.46 TP53 PIK3CA NRAS MDM2 FOXO1 CDK4
11
Show member pathways
12.45 TP53 PIK3CA NRAS MDM2
12
Show member pathways
12.44 TP53 PIK3CA NRAS FGFR4
13
Show member pathways
12.37 TP53 PIK3CA NRAS MDM2 FGFR4
14 12.32 TP53 PIK3CA MDM2 FOXO1
15 12.28 TP53 PIK3CA NRAS MDM2 FOXO1 FGFR4
16 12.27 TP53 PIK3CA NRAS CDK4
17 12.24 TP53 PIK3CA NRAS MDM2
18 12.2 TP53 PIK3CA NRAS MDM2 CDK4
19 12.14 TP53 PAX7 PAX3 MDM2 FOXO1
20 12.1 TP53 MDM2 FOXO1 CDK4
21
Show member pathways
12.09 TP53 PIK3CA NRAS FOXO1
22
Show member pathways
12.03 PIK3CA NRAS MDM2 FOXO1
23 11.94 TP53 PIK3CA NRAS
24 11.93 TP53 PIK3CA NRAS MDM2
25
Show member pathways
11.89 PIK3CA NRAS MDM2
26 11.88 TP53 PIK3CA NRAS MDM2 FOXO1
27 11.84 PIK3CA NRAS FOXO1 CDK4
28 11.84 TP53 PIK3CA NRAS MDM2 FOXO1 CDK4
29 11.81 TP53 PIK3CA CDK4
30 11.81 TP53 NRAS MDM2 FOXO1 CDK4
31 11.8 PIK3CA MDM2 FOXO1
32 11.78 TP53 MDM2 CDK4
33 11.69 TP53 PIK3CA MDM2
34 11.67 TP53 NRAS MDM2 CDK4
35 11.65 TP53 PIK3CA NRAS
36 11.47 TP53 PIK3CA MDM2 FOXO1
37 11.47 TP53 PIK3CA FGFR4 FBXW7 BCOR
38 11.46 TP53 MDM2 CDK4
39 11.44 TP53 MDM2 CDK4
40
Show member pathways
11.35 TP53 PIK3CA NRAS MDM2 FOXO1 FGFR4
41 11.27 TP53 MDM2 CDK4
42 11.23 PIK3CA NRAS FOXO1

GO Terms for Parameningeal Embryonal Rhabdomyosarcoma

Cellular components related to Parameningeal Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.02 TP53 MDM2 KIDINS220 CDK4 ALK

Biological processes related to Parameningeal Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.56 PIK3CA PAX7 MDM2 CDK4
2 muscle organ development GO:0007517 9.5 PAX7 PAX3 MYOG
3 positive regulation of protein export from nucleus GO:0046827 9.43 TP53 MDM2
4 response to hyperoxia GO:0055093 9.4 TP53 CDK4
5 cardiac septum morphogenesis GO:0060411 9.37 TP53 MDM2
6 regulation of cell proliferation GO:0042127 9.26 TP53 FOXO1 CDK4 ALK
7 cellular response to UV-C GO:0071494 9.16 TP53 MDM2
8 cellular response to actinomycin D GO:0072717 8.62 TP53 MDM2

Molecular functions related to Parameningeal Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 9.26 TP53 MDM2 FOXO1 FBXW7
2 DNA-binding transcription factor activity GO:0003700 9.1 TP53 PAX7 PAX3 MYOG GLI4 FOXO1

Sources for Parameningeal Embryonal Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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