MCID: PRM208
MIFTS: 25

Parameningeal Embryonal Rhabdomyosarcoma

Categories: Cancer diseases, Fetal diseases, Muscle diseases
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Aliases & Classifications for Parameningeal Embryonal Rhabdomyosarcoma

MalaCards integrated aliases for Parameningeal Embryonal Rhabdomyosarcoma:

Name: Parameningeal Embryonal Rhabdomyosarcoma 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0060338

Summaries for Parameningeal Embryonal Rhabdomyosarcoma

Disease Ontology: 11 An embryonal rhabdomyosarcoma located in the parameningeal region.

MalaCards based summary: Parameningeal Embryonal Rhabdomyosarcoma is related to embryonal rhabdomyosarcoma and rhabdomyosarcoma. An important gene associated with Parameningeal Embryonal Rhabdomyosarcoma is GLI4 (GLI Family Zinc Finger 4), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Parameningeal Embryonal Rhabdomyosarcoma

Diseases related to Parameningeal Embryonal Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 embryonal rhabdomyosarcoma 29.7 TP53 RHD PAX7 PAX3 MYOG FOXO1
2 rhabdomyosarcoma 29.5 TP53 PAX7 PAX3 NRAS MYOG FOXO1
3 central nervous system rhabdomyosarcoma 10.2 PAX3 FOXO1
4 oral rhabdomyosarcoma 10.2 PAX3 MYOG
5 skeletal muscle neoplasm 10.2 RHD MYOG
6 botryoid rhabdomyosarcoma 10.2 PAX3 MYOG
7 prostate embryonal rhabdomyosarcoma 10.2 PAX3 MYOG
8 adult fibrosarcoma 10.2 PAX3 MYOG
9 hydrocephalus 10.2
10 sarcoma 10.2
11 bell's palsy 10.2
12 acoustic neuroma 10.2
13 facial paralysis 10.2
14 neurilemmoma 10.2
15 cranial nerve palsy 10.2
16 conventional leiomyosarcoma 10.2 PAX7 MYOG
17 inflammatory leiomyosarcoma 10.1 PAX7 MYOG
18 central nervous system mesenchymal non-meningothelial tumor 10.1 PAX7 PAX3 MYOG
19 ectomesenchymoma 10.1 PAX7 PAX3 MYOG
20 spindle cell rhabdomyosarcoma 10.1 PAX7 PAX3 MYOG
21 desmoplastic small round cell tumor 10.1 PAX7 PAX3 MYOG
22 micronodular basal cell carcinoma 10.0 TP53 NRAS
23 breast sarcoma 10.0 TP53 MYOG
24 large cell carcinoma with rhabdoid phenotype 10.0 TP53 MYOG
25 cervical adenosarcoma 10.0 TP53 MYOG
26 malignant spindle cell melanoma 9.9 TP53 NRAS
27 vaginal carcinosarcoma 9.9 TP53 FBXW7
28 breast rhabdomyosarcoma 9.9 PAX7 PAX3 MYOG FOXO1
29 basal cell nevus syndrome 9.9 TP53 PAX7 PAX3
30 myxoid liposarcoma 9.9 TP53 PAX3 FOXO1
31 la crosse encephalitis 9.9 GAS6 AXL
32 adult malignant schwannoma 9.9 TP53 MYOG
33 well-differentiated liposarcoma 9.9 TP53 PAX3 MYOG
34 spindle cell sarcoma 9.9 TP53 PAX3 MYOG
35 conjunctival cancer 9.9 TP53 NRAS
36 myxofibrosarcoma 9.9 TP53 PAX3 MYOG
37 dedifferentiated liposarcoma 9.9 TP53 PAX3 MYOG
38 nodular malignant melanoma 9.9 TP53 NRAS
39 anal squamous cell carcinoma 9.9 TP53 FBXW7
40 carey-fineman-ziter syndrome 1 9.8 PAX7 MYOG
41 rectum adenocarcinoma 9.8 TP53 NRAS FBXW7
42 giant cell glioblastoma 9.8 TP53 NRAS FBXW7
43 progressive relapsing multiple sclerosis 9.8 RHD PAX7 PAX3 MYOG FOXO1
44 ovarian serous cystadenocarcinoma 9.8 TP53 NRAS FBXW7
45 aging 9.8 TP53 NAMPT FOXO1
46 clear cell basal cell carcinoma 9.8 TP53 PAX7 PAX3 MYOG
47 pleomorphic liposarcoma 9.8 TP53 MYOG
48 orbit embryonal rhabdomyosarcoma 9.7 PAX7 PAX3 MYOG FOXO1 FGFR4
49 skin melanoma 9.7 TP53 NRAS FBXW7
50 bladder urothelial carcinoma 9.7 TP53 NRAS FBXW7

Graphical network of the top 20 diseases related to Parameningeal Embryonal Rhabdomyosarcoma:



Diseases related to Parameningeal Embryonal Rhabdomyosarcoma

Symptoms & Phenotypes for Parameningeal Embryonal Rhabdomyosarcoma

GenomeRNAi Phenotypes related to Parameningeal Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.13 ARHGEF25 AXL CDC42 EIF5B FBXW7 FGFR4
2 no effect GR00402-S-2 10.13 ARHGEF25 AXL CDC42 FBXW7 FGFR4 FOXO1

MGI Mouse Phenotypes related to Parameningeal Embryonal Rhabdomyosarcoma:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 AXL CDC42 FBXW7 FGFR4 FOXO1 GAS6
2 growth/size/body region MP:0005378 10.29 AXL CDC42 FBXW7 FGFR4 FOXO1 GAS6
3 normal MP:0002873 10.26 ARHGEF25 AXL CDC42 FBXW7 FOXO1 MYOG
4 cellular MP:0005384 10.22 AXL CDC42 FBXW7 FGFR4 FOXO1 GAS6
5 endocrine/exocrine gland MP:0005379 10.15 AXL CDC42 FBXW7 FOXO1 NAMPT NRAS
6 embryo MP:0005380 10.13 CDC42 FBXW7 FOXO1 MYOG NRAS PAX3
7 neoplasm MP:0002006 10.11 FBXW7 FGFR4 FOXO1 NRAS PAX3 PAX7
8 muscle MP:0005369 10.09 CDC42 FOXO1 MYOG PAX3 PAX7 TP53
9 cardiovascular system MP:0005385 10.07 ARHGEF25 AXL CDC42 FBXW7 FOXO1 GAS6
10 digestive/alimentary MP:0005381 10.06 CDC42 FBXW7 FOXO1 NRAS PAX3 PAX7
11 craniofacial MP:0005382 10.03 CDC42 FBXW7 FOXO1 NRAS PAX3 PAX7
12 limbs/digits/tail MP:0005371 10.01 CDC42 FOXO1 NRAS PAX3 TP53 VCL
13 vision/eye MP:0005391 9.91 AXL CDC42 FBXW7 GAS6 NAMPT NRAS
14 hematopoietic system MP:0005397 9.9 AXL CDC42 FBXW7 FGFR4 FOXO1 GAS6
15 respiratory system MP:0005388 9.87 CDC42 FBXW7 FGFR4 MYOG PAX3 PAX7
16 mortality/aging MP:0010768 9.83 ARHGEF25 AXL CDC42 EIF5B FBXW7 FGFR4
17 integument MP:0010771 9.28 AXL CDC42 FBXW7 FOXO1 MYOG NRAS

Drugs & Therapeutics for Parameningeal Embryonal Rhabdomyosarcoma

Search Clinical Trials, NIH Clinical Center for Parameningeal Embryonal Rhabdomyosarcoma

Genetic Tests for Parameningeal Embryonal Rhabdomyosarcoma

Anatomical Context for Parameningeal Embryonal Rhabdomyosarcoma

Publications for Parameningeal Embryonal Rhabdomyosarcoma

Articles related to Parameningeal Embryonal Rhabdomyosarcoma:

# Title Authors PMID Year
1
A rare presentation of a bilateral intracranial parameningeal embryonal rhabdomyosarcoma mimicking vestibular schwannoma in a two-year-old child: a case report. 62
36355193 2022
2
A Patient-Derived Xenograft Model of Parameningeal Embryonal Rhabdomyosarcoma for Preclinical Studies. 62
26696773 2015
3
Congenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infant. 62
16283194 2006
4
Ophthalmic involvement as a presenting feature of nonorbital childhood parameningeal embryonal rhabdomyosarcoma. 62
11150285 2001
5
Parameningeal embryonal rhabdomyosarcoma in an adult. 62
11225232 1999
6
Acute renal failure in high dose carboplatin chemotherapy. 62
7565311 1995

Variations for Parameningeal Embryonal Rhabdomyosarcoma

Expression for Parameningeal Embryonal Rhabdomyosarcoma

Search GEO for disease gene expression data for Parameningeal Embryonal Rhabdomyosarcoma.

Pathways for Parameningeal Embryonal Rhabdomyosarcoma

Pathways related to Parameningeal Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 AXL CDC42 FGFR4 FOXO1 GAS6 NRAS
2
Show member pathways
13.51 VCL TP53 NRAS GAS6 FGFR4 CDC42
3
Show member pathways
13.17 CDC42 FBXW7 FGFR4 FOXO1 NRAS VCL
4 13.02 VCL TP53 NRAS FOXO1 FGFR4 FBXW7
5
Show member pathways
13.01 AXL CDC42 FGFR4 FOXO1 GAS6 NRAS
6
Show member pathways
12.85 TP53 NRAS GAS6 FGFR4 CDC42
7
Show member pathways
12.51 VCL TP53 NRAS CDC42
8 12.06 TP53 NRAS FGFR4 CDC42
9 11.95 TP53 FOXO1 CDC42
10 11.92 GAS6 FGFR4 AXL
11
Show member pathways
11.92 TP53 NRAS FOXO1 FGFR4
12 11.84 TP53 PAX3 CDC42
13
Show member pathways
11.84 NRAS GAS6 FGFR4 CDC42 AXL
14 11.82 GAS6 CDC42 AXL
15 11.69 TP53 NRAS CDC42
16 11.63 PAX7 PAX3 MYOG
17 11.23 TP53 FGFR4 FBXW7
18 11.1 VCL NRAS FGFR4 CDC42
19 10.75 TP53 NAMPT
20 10.5 NAMPT FOXO1
21 10.36 TP53 NAMPT

GO Terms for Parameningeal Embryonal Rhabdomyosarcoma

Biological processes related to Parameningeal Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anatomical structure development GO:0048856 9.8 PAX7 PAX3 MYOG
2 cellular response to interferon-alpha GO:0035457 9.67 GAS6 AXL
3 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.62 GAS6 AXL
4 negative regulation of dendritic cell apoptotic process GO:2000669 9.56 GAS6 AXL
5 positive regulation of natural killer cell differentiation GO:0032825 9.46 GAS6 AXL
6 enzyme-linked receptor protein signaling pathway GO:0007167 9.13 GAS6 AXL
7 positive regulation of pinocytosis GO:0048549 8.92 CDC42 AXL

Sources for Parameningeal Embryonal Rhabdomyosarcoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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