MCID: PRN021
MIFTS: 44

Paranasal Sinus Disease

Categories: Respiratory diseases

Aliases & Classifications for Paranasal Sinus Disease

MalaCards integrated aliases for Paranasal Sinus Disease:

Name: Paranasal Sinus Disease 12 15 17
Paranasal Sinus Diseases 44 70
Disorder of Nasal Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1352
MeSH 44 D010254
NCIt 50 C26843
SNOMED-CT 67 7393007
UMLS 70 C0030469

Summaries for Paranasal Sinus Disease

MalaCards based summary : Paranasal Sinus Disease, also known as paranasal sinus diseases, is related to rhinitis and uveitis. An important gene associated with Paranasal Sinus Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Amoxicillin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and thyroid, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity. The... more...

Related Diseases for Paranasal Sinus Disease

Diseases related to Paranasal Sinus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 614)
# Related Disease Score Top Affiliating Genes
1 rhinitis 30.6 IL5 IL4 IL17A IL13 IL10 IFNG
2 uveitis 30.6 IL4 IL17A IL10 IFNG
3 frontal sinusitis 30.6 PRTN3 CRP
4 invasive aspergillosis 30.5 IL10 IFNG CCR6
5 chronic rhinitis 30.5 IL5 IL4 IL13 DNAH5
6 osteomyelitis 30.5 IL4 IL10 IFNG CRP
7 bronchitis 30.4 IL5 IL4 IL13 IL10 CRP CFTR
8 ethmoid sinusitis 30.4 PRTN3 DNAI1 CRP
9 hypereosinophilic syndrome 30.4 IL5 IL4 IL13 IFNG ALOX5
10 cellulitis 30.4 IL5 CRP CD4 CCR6
11 allergic rhinitis 30.3 IL5 IL4 IL17A IL13 IL10 IFNG
12 bronchiectasis 30.2 DNAI1 DNAH5 CRP CFTR
13 aspergillosis 30.2 IL5 IL4 IL10 IFNG CFTR CCR6
14 optic nerve disease 30.2 IL17A ICOSLG CRP CD4 CCR6
15 orbital cellulitis 30.2 CRP CD4
16 cystic fibrosis 29.8 TGFB1 PRTN3 IL5 IL4 IL17A IL13
17 respiratory failure 29.7 PLAUR IL5 IL13 IL10 CRP CFTR
18 neurosyphilis 10.5 IL17A IL10
19 cytokine deficiency 10.5 IL5 IL13
20 aztreonam allergy 10.5 IL5 IL13
21 tropical endomyocardial fibrosis 10.5 IL4 IL10
22 eosinophilic fasciitis 10.5 IL5 IFNG
23 cefaclor allergy 10.5 IL5 IL13
24 juvenile myasthenia gravis 10.5 TGFB1 IL10
25 cefuroxime allergy 10.5 IL5 IL13
26 ceftriaxone allergy 10.5 IL5 IL13 IL10
27 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL5 IL13
28 cow milk allergy 10.5 IL5 IL4 IL10
29 acute asthma 10.5 IL5 IL4 ALOX5
30 kimura disease 10.5 IL5 IL4 IL13
31 vernal keratoconjunctivitis 10.5 IL5 IL4 IL13
32 atopic keratoconjunctivitis 10.5 IL5 IL4 IFNG
33 toxic oil syndrome 10.5 IL5 IL4 IFNG
34 polyradiculoneuropathy 10.5 IL17A IL10 IFNG
35 endomyocardial fibrosis 10.5 IL5 IL4 IL10
36 spotted fever rickettsiosis 10.5 IL10 IFNG
37 beta-lactam allergy 10.5 IL4 IL13 IL10
38 respiratory syncytial virus infectious disease 10.5 IL5 IL13
39 orofacial granulomatosis 10.5 IL4 IL10 IFNG
40 mansonelliasis 10.5 IL5 IL10 IFNG
41 eales disease 10.5 IL4 IL10 IFNG
42 aneruptive fever 10.5 IL13 GATA3
43 psoriasis 15 10.5 IL4 IL17A IL13
44 african tick-bite fever 10.5 IL13 IL10 IFNG
45 ascaris lumbricoides infection 10.5 IL5 IL13 IFNG
46 acute gonococcal cervicitis 10.5 IL4 IL10
47 necrotic uveal melanoma 10.5 IFNG CD4
48 cystic fibrosis and congenital absence of the vas deferens 10.5 TGFB1 CFTR
49 acute graft versus host disease 10.5 IL4 IL10 IFNG
50 eosinophilia-myalgia syndrome 10.5 TGFB1 IL5 IFNG

Graphical network of the top 20 diseases related to Paranasal Sinus Disease:



Diseases related to Paranasal Sinus Disease

Symptoms & Phenotypes for Paranasal Sinus Disease

MGI Mouse Phenotypes related to Paranasal Sinus Disease:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.43 ALOX5 CCR6 CD4 CFTR DNAH5 DNAI1
2 immune system MP:0005387 10.41 ALOX5 CCR6 CD4 CFTR CRP DNAH5
3 growth/size/body region MP:0005378 10.37 CD4 CFTR DNAH5 DNAI1 GATA3 IFNG
4 cellular MP:0005384 10.36 ALOX5 CD4 DNAH5 DNAI1 GATA3 IFNG
5 homeostasis/metabolism MP:0005376 10.36 ALOX5 CCR6 CD4 CFTR CRP GATA3
6 cardiovascular system MP:0005385 10.3 ALOX5 CRP DNAH5 DNAI1 GATA3 IFNG
7 digestive/alimentary MP:0005381 10.3 CD4 CFTR DNAH5 GATA3 IFNG IL10
8 endocrine/exocrine gland MP:0005379 10.25 CD4 CFTR DNAH5 GATA3 IFNG IL10
9 craniofacial MP:0005382 10.24 CFTR DNAH5 DNAI1 GATA3 IFNG IL10
10 integument MP:0010771 10.1 CD4 GATA3 IFNG IL10 IL13 IL17A
11 nervous system MP:0003631 10.1 CCR6 CD4 DNAH5 DNAI1 GATA3 IFNG
12 liver/biliary system MP:0005370 10.07 CFTR DNAH5 IFNG IL10 IL4 IL5
13 no phenotypic analysis MP:0003012 9.91 CD4 CFTR GATA3 IFNG IL10 IL13
14 respiratory system MP:0005388 9.77 CFTR DNAH5 DNAI1 IFNG IL10 IL13
15 renal/urinary system MP:0005367 9.76 DNAH5 GATA3 IFNG IL17A IL4 PLAUR
16 skeleton MP:0005390 9.4 ALOX5 DNAH5 DNAI1 GATA3 IFNG IL10

Drugs & Therapeutics for Paranasal Sinus Disease

Drugs for Paranasal Sinus Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
2
Ofloxacin Approved Phase 3 82419-36-1 4583
3
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
4
Tranexamic Acid Approved Phase 3 1197-18-8 5526
5 Anti-Bacterial Agents Phase 3
6 Anti-Infective Agents Phase 3
7 Cytochrome P-450 Enzyme Inhibitors Phase 3
8 Clavulanic Acids Phase 3
9 Coagulants Phase 3
10 Hemostatics Phase 3
11 Antifibrinolytic Agents Phase 3
12
Bacitracin Approved, Vet_approved Phase 2 1405-87-4 10909430 439542
13 Antibiotics, Antitubercular Phase 2
14 Anti-Infective Agents, Local Phase 2
15
Methylene blue Approved, Investigational 61-73-4
16
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
17
Povidone Approved 9003-39-8 131751496
18
Povidone-iodine Approved 25655-41-8
19
Iodine Approved, Investigational 7553-56-2 807
20
Ivacaftor Approved 873054-44-5 16220172
21
Cadexomer iodine Experimental 94820-09-4
22 Mitogens
23 Pharmaceutical Solutions
24 Anesthetics
25 Surgiflo

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 A Multicenter, Randomized Study to Compare the Safety and Efficacy of Oral Levofloxacin With Amoxicillin/Clavulanate Potassium in the Treatment of Acute Sinusitis in Adults Completed NCT00249210 Phase 3 levofloxacin
2 Does The Combined Use Of Local And Intravenous Tranexamic Acid Offer Better Surgical Field Quality During Functional Endoscopic Sinus Surgery? A Placebo-Controlled Clinical Trial Recruiting NCT03965767 Phase 3 Tranexamic Acid
3 Effectiveness of Antibiotic Delivery Via Bio-absorbable Sponge After Functional Endoscopic Sinus Surgery Completed NCT01222832 Phase 2 Bacitracin
4 Trial of Directed High-dose Nasal Steroids on Residual Olfactory Dysfunction in Patients With Chronic Rhinosinusitis Following Endoscopic Sinus Surgery Withdrawn NCT01814618 Phase 2 Budesonide Respules
5 Photodisinfection for the Treatment of Chronic Rhinosinusitis Unknown status NCT01854619
6 Osteogenic Effects of Concentrated Growth Factors Applied in Maxillary Sinus Floor Elevation Via a Lateral Window Approach With Simultaneous Implant Placement: a Single-center Randomized Controlled Trial Unknown status NCT03046173
7 Upper and Lower Airway Colonization in Cystic Fibrosis Patients After Lung Transplantation Unknown status NCT02591524
8 Large Scale Cerebral Oximetry During Sinus Endoscopy Completed NCT02692794
9 Phase 1 STRENGTHENING OF THE SACROCOCCYGEAL FASCIA IN THE SURGICAL TREATMENT OF PILONIDAL SINUS DISEASE Completed NCT01876537
10 Pilonidal Sinus Disease: Preliminary Case-control Study on Heat-related Wound Dehiscence Completed NCT03764657
11 Comparative Analysis of the Same technique-the Same Surgeon Approach in the Surgical Treatment of Pilonidal Sinus Disease: A Retrospective Cohort Study Completed NCT02849197
12 Effectiveness of Limberg and Karydakis Flap in Recurrent Pilonidal Sinus Disease Completed NCT02287935
13 A Proposed Staging System for Chronic Symptomatic Pilonidal Sinus Disease and Results in Patients Treated With Stage-based Approach Completed NCT02712970
14 Application of Platelet-rich Plasma for the Management of Pilonidal Sinus Disease: A Randomized Clinical Trial of Different Treatment Modalities Completed NCT04697082
15 BREATHE Long-Term Follow-Up Study Completed NCT01319305
16 Treatment of Pilonidal Sinus Disease Using Surgiflo as a Sealant: A New Concept Completed NCT02638064
17 Lay Open and Curettage Versus Endoscopic (E.P.Si.T) Method in the Treatment of Sacrococcygeal Pilonidal Sinus Disease Recruiting NCT04418310
18 Impact of Elexacaftor-tezacaftor-ivacaftor Triple Combination CFTR Therapy on Sinus Disease: Quantitative Sinus Computed Tomography, Patient Reported Outcomes and Cellular and Molecular Changes Recruiting NCT04056702 Elexacaftor-tezacaftor-ivacaftor exposure
19 Association Between Periodontal Bone Loss and Maxillary Sinus Changes Determined Using Cone Beam Computed Tomography - A Retrospective Study Not yet recruiting NCT04702867

Search NIH Clinical Center for Paranasal Sinus Disease

Cochrane evidence based reviews: paranasal sinus diseases

Genetic Tests for Paranasal Sinus Disease

Anatomical Context for Paranasal Sinus Disease

MalaCards organs/tissues related to Paranasal Sinus Disease:

40
Bone, Eye, Thyroid

Publications for Paranasal Sinus Disease

Articles related to Paranasal Sinus Disease:

(show top 50) (show all 298)
# Title Authors PMID Year
1
Olfactory changes after endoscopic sinus surgery for chronic rhinosinusitis: A meta-analysis. 61
32865350 2021
2
Cone-beam computed tomographic imaging of silent sinus syndrome: A case series and a literature review. 61
33409147 2020
3
A long-term study of sinoscopic treatment of equine paranasal sinus disease: 155 cases (2012-2019). 61
33222250 2020
4
Optimization of paranasal sinus CT procedure: Ultra-low dose CT as a roadmap for pre-functional endoscopic sinus surgery. 61
33038645 2020
5
Frontoethmoidal mucocele presenting with ocular manifestations. 61
31773805 2020
6
Paranasal sinus disease could be a reason for unsuccessful immunotherapy of inhalant allergy in children. 61
32334922 2020
7
Unusual Brain MRI Findings in Patients Imaged for Headache: a Case Series. 61
32691182 2020
8
Computed Tomographic Study of Remarkable Anatomic Variations in Paranasal Sinus Region and their Clinical Importance - A Retrospective Study. 61
33708589 2020
9
Computed tomography characteristics of equine paranasal sinus cysts. 61
31793020 2020
10
Comparative studies on the histological characteristics of equine nasomaxillary aperture and paranasal sinus mucosa considering topographic and age-related differences. 61
32576268 2020
11
Pathological and therapeutic implications of eosinophil-derived semaphorin 4D in eosinophilic chronic rhinosinusitis. 61
32035658 2020
12
Incidence and Radiological Findings of Incidental Sinus Opacifications in Patients Undergoing Septoplasty or Septorhinoplasty. 61
31540552 2020
13
Nasal Nitric Oxide in Chronic Rhinosinusitis with or without Nasal Polyps: A Systematic Review with Meta-Analysis. 61
31940834 2020
14
A Rare Intraorbital Mass: An Isolated Mucocele. 61
33717628 2020
15
Nasal Endoscopy as an Effective Alternative for CT-Scan in Diagnosing Chronic Rhinosinusitis: A Clinical Study and Review of Literature. 61
31763235 2019
16
Surgical Approaches in the Treatment of Intracranial Complications of Paranasal Sinus Disease: A Review of the Literature. 61
31254711 2019
17
Streptococcus equi subsp. zooepidemicus and 'Neighbourhood syndrome' -extra-orbitocranial rhinosinusitis with reversible sudden loss of vision- a case report. 61
31109307 2019
18
Nontraumatic emergencies of inflammatory paranasal sinus disease. 61
31030736 2019
19
A bilateral sinus cyst treated via a bilateral frontonasal bone flap in a standing horse. 61
31038323 2019
20
Maxillary sinus pain with radiolucent sinuses due to agenesis of the membranous ostium. 61
30344083 2019
21
Choanal polyps in children and adults: 10-year experience from a tertiary care hospital. 61
30430241 2019
22
An Emergent Entity: Indolent Mucormycosis of the Paranasal Sinuses. A Multicenter Study. 61
30647791 2019
23
Diffusion-weighted magnetic resonance imaging of the paranasal sinuses: A systematic review. 61
30143461 2018
24
CNS aspergilloma mimicking tumors: Review of CNS aspergillus infection imaging characteristics in the immunocompetent population. 61
29273531 2018
25
Frontal sinusitis complicated by a brain abscess and subdural empyema. 61
29682134 2018
26
Respiratory Epithelial Orbital Cyst: A Case Report and Literature Review. 61
29651357 2018
27
Diagnosis and treatment of nasal and paranasal inverted papillomas - epidemiology and own experience. 61
29327684 2017
28
Isolated cerebral aspergillosis in an immunocompetent woman on treatment for bacterial infected necrotizing pancreatitis: A case report. 61
29310378 2017
29
Paranasal Sinus Disease in Children With Headache. 61
28831857 2017
30
Prevalence and Seasonal Variation of Incidental MRI Paranasal Inflammatory Changes in an Asymptomatic Irish Population. 61
29372956 2017
31
Surgical treatment of chronic rhinosinusitis after sinus lift. 61
28716179 2017
32
The Possible Role of Endoscopy in Diagnosis of Benign Tumors of the Nasal Cavity. 61
28169906 2017
33
Paranasal sinus opacification in headache sufferers: A population-based imaging study (the HUNT study-MRI). 61
27215544 2017
34
Orbital Cellulitis in a Psoriatic Patient Treated With Adalimumab. 61
28290979 2017
35
Pretransplant paranasal sinus disease is associated with a high incidence of transplant-related mortality in hematopoietic stem cell transplantation for children and adolescents. 61
27748554 2016
36
Anatomical Variations of the Anterior Clinoid Process: A Study of 597 Skull Base Computerized Tomography Scans. 61
29506115 2016
37
In the era of endoscopic sinus surgery, is there still a place for the Caldwell-Luc procedure?. 61
29553613 2016
38
Rhinoscintigraphic analysis of nasal mucociliary function in patients with Bell's palsy. 61
27022800 2016
39
Higher Body Mass Index and Increased Prevalence of Paranasal Sinus Disease. 61
26830349 2016
40
Surgical Treatment of Rhinogenic Contact Point Headache: An Experience from a Tertiary Care Hospital. 61
27096023 2016
41
The analysis of the maxillary sinus volumes and the nasal septal deviation in patients with antrochoanal polyps. 61
25534286 2015
42
Occupational and environmental risk factors for chronic rhinosinusitis: a systematic review. 61
26077513 2015
43
Attitudes on and usage of balloon catheter technology in rhinology: A survey of the American Rhinologic Society. 61
26358353 2015
44
Empyema of the nasal conchal bulla as a cause of chronic unilateral nasal discharge in the horse: 10 cases (2013-2014). 61
25041424 2015
45
Nasal Cavity and Paranasal Sinus Diseases Affecting Orbit. 61
26080260 2015
46
IgG4-Related Ophthalmic Disease. Part II: Clinical Aspects. 61
25564258 2015
47
Retrobulbar optic neuropathy secondary to isolated sphenoid sinus disease. 61
25883489 2015
48
IgG4-related ophthalmic disease. Part I: background and pathology. 61
25564257 2015
49
A Fulminant Case of Granulomatosis with Polyangiitis with Meningeal and Parenchymal Involvement. 61
26327907 2015
50
Comprehensive review on endonasal endoscopic sinus surgery. 61
26770282 2015

Variations for Paranasal Sinus Disease

Expression for Paranasal Sinus Disease

Search GEO for disease gene expression data for Paranasal Sinus Disease.

Pathways for Paranasal Sinus Disease

Pathways related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 TGFB1 PRTN3 PLAUR PLAU IL5 IL4
2
Show member pathways
13.7 TGFB1 IL5 IL4 IL17A IL13 IL10
3
Show member pathways
13.54 TGFB1 IL5 IL4 IL17A IL13 IL10
4
Show member pathways
13.42 TGFB1 IL5 IL4 IL17A IL13 IL10
5
Show member pathways
13.39 TGFB1 PRTN3 IL5 IL4 IL17A IL13
6
Show member pathways
13.32 TGFB1 IL5 IL4 IL17A IL13 IL10
7
Show member pathways
13.31 TGFB1 SERPINE1 PRTN3 PLAUR PLAU IL5
8
Show member pathways
12.87 TGFB1 IL5 IL4 IL17A IL13 IL10
9
Show member pathways
12.64 IL4 IL10 IFNG ICOSLG CD4
10
Show member pathways
12.64 TGFB1 IL5 IL4 IL17A IL10 IFNG
11 12.6 IL4 IL17A IL10 IFNG GATA3 ALOX5
12
Show member pathways
12.51 TGFB1 IL5 IL4 IL17A IL13 IL10
13
Show member pathways
12.44 IL5 IL4 IL13 IL10 IFNG
14
Show member pathways
12.4 IL5 IL4 IL17A IL13 IFNG CFTR
15
Show member pathways
12.37 SERPINE1 IL4 IFNG CRP ALOX5
16
Show member pathways
12.31 TGFB1 IL5 IL4 IL17A IL13 IL10
17
Show member pathways
12.29 TGFB1 IL4 IL10 IFNG ALOX5
18 12.06 IL5 IL4 IL10 IFNG CD4
19 11.98 TGFB1 SERPINE1 PLAU IFNG
20 11.97 TGFB1 IL4 IL17A IL13 IL10 GATA3
21
Show member pathways
11.94 TGFB1 IL4 IL17A IFNG CD4
22 11.88 IL5 IL4 IL13 IFNG GATA3
23 11.83 SERPINE1 IL5 IL10 GATA3
24
Show member pathways
11.81 IL5 IL4 IFNG GATA3
25
Show member pathways
11.81 TGFB1 IL17A IL10 IFNG GATA3 CD4
26 11.79 TGFB1 IL10 IFNG CD4
27 11.77 PRTN3 GATA3 CD4
28 11.74 TGFB1 PLAU IL5 IL4 IL13
29 11.7 TGFB1 IL5 IL4 IL10 ICOSLG CCR6
30 11.67 IL5 IL4 IL10
31 11.65 SERPINE1 PLAUR PLAU
32 11.62 TGFB1 SERPINE1 IFNG
33 11.55 TGFB1 IL10 IFNG
34 11.54 IL4 IL13 IL10
35
Show member pathways
11.4 TGFB1 IL10 IFNG
36 11.36 IL5 IL4 IFNG
37 11.36 IL5 IL4 IL13 IL10 IFNG GATA3
38 11.32 TGFB1 IL13 IFNG CD4
39 11.25 IL5 IL4 IL13 IL10 IFNG
40 11.24 IL5 IL4 IL17A IL13 IFNG GATA3
41 11.18 IL5 IL4 IL17A IL13 IL10 IFNG
42 11.05 TGFB1 IL5 IL4 IL17A IL13 IL10
43 11.03 TGFB1 IL4 GATA3
44 10.96 TGFB1 IL5 IL4 IL13 IL10 IFNG
45 10.9 SERPINE1 PLAUR PLAU
46 10.9 TGFB1 IL5 IL4 IL13

GO Terms for Paranasal Sinus Disease

Cellular components related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TGFB1 SERPINE1 PRTN3 PLAU IL5 IL4
2 external side of plasma membrane GO:0009897 9.65 IL17A IL13 ICOSLG CD4 CCR6
3 cell surface GO:0009986 9.63 TGFB1 PLAUR PLAU CFTR CD4 CCR6
4 extracellular region GO:0005576 9.5 TGFB1 SERPINE1 PRTN3 PLAUR PLAU IL5

Biological processes related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.27 PLAUR PLAU IL5 IL4 IL10 ICOSLG
2 positive regulation of transcription, DNA-templated GO:0045893 10.11 TGFB1 IL5 IL4 IL10 GATA3 CD4
3 positive regulation of gene expression GO:0010628 9.97 TGFB1 IL4 IL13 IFNG GATA3 CRP
4 positive regulation of protein phosphorylation GO:0001934 9.94 TGFB1 PLAUR IFNG CD4
5 blood coagulation GO:0007596 9.94 PRTN3 PLAUR PLAU GATA3
6 inflammatory response GO:0006954 9.91 TGFB1 IL5 IL17A IL13 CRP ALOX5
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 IL4 IL13 IFNG
8 positive regulation of cytokine production GO:0001819 9.8 IL10 IFNG GATA3
9 immune response GO:0006955 9.76 IL5 IL4 IL17A IL13 IL10 IFNG
10 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.74 TGFB1 IL10 GATA3
11 positive regulation of B cell proliferation GO:0030890 9.73 IL5 IL4 IL13
12 T cell differentiation GO:0030217 9.72 TGFB1 GATA3 CD4
13 negative regulation of inflammatory response GO:0050728 9.72 IL4 IL13 IL10 GATA3 ALOX5
14 humoral immune response GO:0006959 9.71 IFNG GATA3 CCR6 ALOX5
15 microglial cell activation GO:0001774 9.69 IL4 IL13 IFNG
16 positive regulation of interleukin-13 production GO:0032736 9.66 IL4 GATA3
17 negative regulation of vascular wound healing GO:0061044 9.65 SERPINE1 ALOX5
18 positive regulation of mast cell degranulation GO:0043306 9.65 IL4 IL13
19 fibrinolysis GO:0042730 9.65 SERPINE1 PLAUR PLAU
20 positive regulation of immunoglobulin production GO:0002639 9.63 IL5 IL13 IL10
21 positive regulation of mononuclear cell migration GO:0071677 9.62 TGFB1 IL4
22 positive regulation of cellular respiration GO:1901857 9.61 IL4 IFNG
23 neuroinflammatory response GO:0150076 9.61 IL4 IFNG
24 lymphocyte migration GO:0072676 9.6 GATA3 CCR6
25 type 2 immune response GO:0042092 9.59 IL4 IL10
26 positive regulation of interleukin-23 production GO:0032747 9.58 IL17A IFNG
27 T-helper 2 cell differentiation GO:0045064 9.58 IL4 GATA3
28 T cell activation GO:0042110 9.56 TGFB1 IL4 ICOSLG CD4
29 negative regulation of complement-dependent cytotoxicity GO:1903660 9.54 IL4 IL13
30 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL4 IL10 IFNG
31 regulation of isotype switching GO:0045191 9.52 IL4 IL10
32 negative regulation of endothelial cell apoptotic process GO:2000352 9.35 SERPINE1 IL4 IL13 IL10 GATA3
33 cytokine-mediated signaling pathway GO:0019221 9.32 TGFB1 PRTN3 IL5 IL4 IL17A IL13

Molecular functions related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.65 SERPINE1 PRTN3 PLAUR ICOSLG CD4
2 enzyme binding GO:0019899 9.55 TGFB1 PRTN3 PLAUR CFTR CD4
3 growth factor activity GO:0008083 9.26 TGFB1 IL5 IL4 IL10
4 cytokine activity GO:0005125 9.17 TGFB1 IL5 IL4 IL17A IL13 IL10

Sources for Paranasal Sinus Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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