MCID: PRN021
MIFTS: 47

Paranasal Sinus Disease

Categories: Respiratory diseases

Aliases & Classifications for Paranasal Sinus Disease

MalaCards integrated aliases for Paranasal Sinus Disease:

Name: Paranasal Sinus Disease 12 15
Paranasal Sinus Diseases 44 73
Disorder of Nasal Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1352
MeSH 44 D010254
NCIt 50 C26843
SNOMED-CT 68 7393007
UMLS 73 C0030469

Summaries for Paranasal Sinus Disease

MalaCards based summary : Paranasal Sinus Disease, also known as paranasal sinus diseases, is related to aspergillosis and asthma. An important gene associated with Paranasal Sinus Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Strawberry and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and lung, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Wikipedia : 76 Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity. The... more...

Related Diseases for Paranasal Sinus Disease

Diseases related to Paranasal Sinus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 30.0 IFNG IL10 IL4 IL5
2 asthma 29.1 ALOX5 GATA3 IFNG IL10 IL13 IL17A
3 intrinsic asthma 10.3 IL4 IL5
4 trichinosis 10.3 IL4 IL5
5 chronic graft versus host disease 10.3 IFNG IL10
6 cytokine deficiency 10.3 IL13 IL5
7 eosinophilic fasciitis 10.3 IFNG IL5
8 tropical endomyocardial fibrosis 10.3 IL10 IL4
9 endomyocardial fibrosis 10.3 IL10 IL4
10 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL13 IL5
11 autoimmune myocarditis 10.3 IFNG IL4
12 b-cell growth factor 10.3 IFNG IL4
13 respiratory syncytial virus infectious disease 10.3 IL13 IL5
14 juvenile myasthenia gravis 10.2 IL10 TGFB1
15 african tick-bite fever 10.2 IFNG IL13
16 rhinitis 10.2 IL13 IL4 IL5
17 ascaridiasis 10.2 IL10 IL13
18 tungiasis 10.2 IL10 IL4
19 inflammatory bowel disease 4 10.2 IL13 IL4 IL5
20 latex allergy 10.2 IL13 IL4 IL5
21 intestinal schistosomiasis 10.2 IL13 IL4 IL5
22 scleritis 10.2 IFNG IL4 IL5
23 chronic tic disorder 10.2 IL13 IL4 IL5
24 atopic keratoconjunctivitis 10.2 IFNG IL4 IL5
25 chronic conjunctivitis 10.2 IL13 IL4 IL5
26 eosinophilic gastritis 10.2 IL13 IL4 IL5
27 vernal keratoconjunctivitis 10.2 IL13 IL4 IL5
28 inflammatory bowel disease 25, autosomal recessive 10.2 IL10 TGFB1
29 paragonimiasis 10.2 IL13 IL5
30 cough variant asthma 10.2 IL4 IL5
31 ascaris lumbricoides infection 10.2 IFNG IL13 IL5
32 toxic oil syndrome 10.2 IFNG IL4 IL5
33 pulmonary eosinophilia 10.2 IL13 IL4 IL5
34 folliculitis 10.2 IFNG IL4 IL5
35 sporotrichosis 10.2 IFNG IL10
36 onchocerciasis 10.2 IL13 IL4 IL5
37 gaucher disease, type ii 10.2 IL10 IL4 IL5
38 cephalosporin allergy 10.2 IFNG IL10 IL5
39 filarial elephantiasis 10.2 IL10 IL4 IL5
40 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IFNG IL13 IL5
41 hyperlucent lung 10.2 IFNG IL10 IL4
42 beta-lactam allergy 10.2 IL10 IL13 IL4
43 milk allergy 10.2 IL10 IL4 IL5
44 baylisascariasis 10.2 IFNG IL10 IL4
45 eosinophilia-myalgia syndrome 10.2 IFNG IL5 TGFB1
46 necatoriasis 10.2 IL10 IL5
47 perforated corneal ulcer 10.2 PLAU PLAUR
48 orofacial granulomatosis 10.2 IFNG IL10 IL4
49 buruli ulcer 10.2 IFNG IL10 IL4
50 poliomyelitis 10.2 IFNG IL10 IL4

Graphical network of the top 20 diseases related to Paranasal Sinus Disease:



Diseases related to Paranasal Sinus Disease

Symptoms & Phenotypes for Paranasal Sinus Disease

GenomeRNAi Phenotypes related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 FLNC IL17A IL5 NODAL PLAUR TGFB1

MGI Mouse Phenotypes related to Paranasal Sinus Disease:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 ALOX5 FLNC GATA3 IFNG IL10 IL13
2 growth/size/body region MP:0005378 10.4 FLNC GATA3 IFNG IL10 IL13 IL17A
3 hematopoietic system MP:0005397 10.39 ALOX5 GATA3 IFNG IL10 IL13 IL17A
4 immune system MP:0005387 10.37 ALOX5 GATA3 IFNG IL10 IL13 IL17A
5 cellular MP:0005384 10.33 ALOX5 GATA3 IFNG IL10 IL13 IL4
6 cardiovascular system MP:0005385 10.3 ALOX5 FLNC GATA3 IFNG IL10 NODAL
7 digestive/alimentary MP:0005381 10.27 GATA3 IFNG IL10 IL13 IL17A IL4
8 mortality/aging MP:0010768 10.26 FLNC GATA3 IFNG IL10 IL13 IL17A
9 craniofacial MP:0005382 10.19 GATA3 IFNG IL10 IL17A IL4 NODAL
10 endocrine/exocrine gland MP:0005379 10.17 GATA3 IFNG IL10 IL13 IL17A IL4
11 integument MP:0010771 10.16 FLNC GATA3 IFNG IL10 IL13 IL4
12 liver/biliary system MP:0005370 10.15 IFNG IL10 IL4 IL5 NODAL PLAU
13 muscle MP:0005369 10.11 FLNC GATA3 IFNG IL10 IL13 NODAL
14 nervous system MP:0003631 10.06 GATA3 IFNG IL10 IL13 IL4 NODAL
15 respiratory system MP:0005388 9.97 FLNC IFNG IL10 IL13 IL17A IL4
16 neoplasm MP:0002006 9.91 IFNG IL10 IL5 PLAU SERPINE1 TGFB1
17 no phenotypic analysis MP:0003012 9.91 GATA3 IFNG IL10 IL13 IL17A IL4
18 reproductive system MP:0005389 9.91 GATA3 IFNG IL10 IL13 IL4 IL5
19 renal/urinary system MP:0005367 9.87 GATA3 IFNG IL17A IL4 PLAUR SERPINE1
20 skeleton MP:0005390 9.65 ALOX5 GATA3 IFNG IL10 IL13 IL17A
21 vision/eye MP:0005391 9.17 GATA3 IFNG IL10 IL4 NODAL PLAU

Drugs & Therapeutics for Paranasal Sinus Disease

Drugs for Paranasal Sinus Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 350)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Strawberry Approved Phase 4,Phase 3
2
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
3
Cefditoren Approved, Investigational Phase 4 117467-28-4, 104145-95-1 9571074 9870843
4
Montelukast Approved Phase 4 158966-92-8 5281040
5
mometasone furoate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 83919-23-7
6
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51333-22-3 63006 5281004
7
Prednisone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 53-03-2 5865
8
Racepinephrine Approved Phase 4,Phase 3,Not Applicable 329-65-7 838
9
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 51-43-4 5816
10
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
11
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
12
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
13
Azithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 83905-01-5 55185 447043
14
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
15
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
16
Cocaine Approved, Illicit Phase 4 50-36-2 5760 446220
17
Remifentanil Approved Phase 4 132875-61-7 60815
18
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
19
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 124-94-7 31307
20
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
21
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
22
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3 302-25-0
23
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3 2921-57-5
24
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
25
Moxifloxacin Approved, Investigational Phase 4,Phase 3 354812-41-2, 151096-09-2 152946
26
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
27
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
28 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3 979-32-8
29
Norgestimate Approved, Investigational Phase 4,Phase 3 35189-28-7 6540478
30
Ofloxacin Approved Phase 4,Phase 3,Phase 1,Phase 2 82419-36-1 4583
31
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 100986-85-4 149096
32
Cefdinir Approved Phase 4 91832-40-5 6915944
33
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
34
Pseudoephedrine Approved Phase 4,Phase 2,Not Applicable 90-82-4 7028
35
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
36
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Not Applicable 103-90-2 1983
37
Ephedrine Approved Phase 4,Phase 2,Not Applicable 299-42-3 9294
38
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
39
Thrombin Approved, Investigational Phase 4
40
Telithromycin Approved Phase 4,Phase 3 191114-48-4 0 5462516
41
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2 242138-07-4
42
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
43
Almotriptan Approved, Investigational Phase 4 154323-57-6, 181183-52-8 123606
44
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
45
Clarithromycin Approved Phase 4,Phase 3,Not Applicable 81103-11-9 84029
46
Bacitracin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 1405-87-4 10909430 439542
47
Citalopram Approved Phase 4 59729-33-8 2771
48
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
49
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3 2920-86-7
50 beta-Lactamase Inhibitors Phase 4,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 385)
# Name Status NCT ID Phase Drugs
1 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
2 Study of Cefditoren Pivoxil in Treatment of Childhood With Acute Rhinosinusitis Unknown status NCT01553006 Phase 4 cefditoren pivoxil
3 Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery Unknown status NCT02110654 Phase 4 Montelukast;mometasone furoate nasal spray
4 Total Intravenous Anesthesia in Sinus Surgery Completed NCT02578862 Phase 4 Propofol;Sevoflurane
5 Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis Completed NCT00396162 Phase 4 probiotic containing L.rhamnosus R0011 strain
6 The PIO II Study: In-office Post-op Placement of a Steroid-eluting Sinus Implant Completed NCT02668302 Phase 4
7 Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate Completed NCT02340000 Phase 4 standard dose amoxicillin/clavulanate;high dose amoxicillin/clavulanate
8 Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy Completed NCT02307825 Phase 4 Azithromycin;Placebo
9 Efficacy and Safety of Sinusitis Hevert SL Tablets Compared to Placebo in Adult Patients With Acute, Uncomplicated Rhinosinusitis Completed NCT02296814 Phase 4 Sinusitis Hevert SL Tablet;Placebo for Sinusitis Hevert SL Tablet
10 The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device Completed NCT02079792 Phase 4
11 Prophylactic Antibiotics After Functional Endoscopic Sinus Surgery: a Randomized, Double-blind Placebo Controlled Trial Completed NCT01919411 Phase 4 Amoxicillin-Potassium Clavulanate;Placebo
12 Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis Completed NCT01825408 Phase 4 Doxycycline;Azithromycin;Augmentin
13 Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery Completed NCT01706952 Phase 4 Cocaine;Adrenaline
14 Saline Irrigation After Surgery in Patients With Chronic Sinusitis Completed NCT01575223 Phase 4
15 Randomized Controlled Trial to Evaluate of Dexmedetomidine for the Effect on Operative Visibility in Patients Undergoing Endoscopic Sinus Surgery Completed NCT01569048 Phase 4 Propofol and dexmedetomidine;propofol and remifentanil
16 Medicated Punctured-Glove-Finger Spacer Study Completed NCT01420471 Phase 4 Triamcinolone
17 Systemic Methylprednisolone in Chronic Rhinosinusitis Completed NCT01205984 Phase 4 methylprednisolone
18 Sinuclean's Treatment Of Sinusitis' Symptoms Completed NCT00747747 Phase 4
19 Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox Completed NCT00668304 Phase 4 Avelox (Moxifloxacin, BAY12-8039)
20 Study of the Safety and Efficacy of Cefdinir and Levofloxacin for the Treatment of Subjects With Acute Bacterial Sinusitis Completed NCT00645073 Phase 4 cefdinir (Omnicef);levofloxacin
21 Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel Completed NCT00554190 Phase 4
22 Treatment of Acute Sinusitis Completed NCT00377403 Phase 4 Acetaminophen;Amoxicillin;Dextromethorphan hydrobromide with guaifenesin;Guaifenesin;Pseudoephedrine Sustained Action;Saline spray (0.65%)
23 Zmax Compared to Augmentin in Sinusitis Completed NCT00367120 Phase 4 Azithromycin Extended Release;Amoxicillin/Clavulanate
24 Hemostatic Matrix in Endoscopic Sinus Surgery Completed NCT00242437 Phase 4
25 CHOOSE : Telithromycin, Acute Bacterial Sinusitis Completed NCT00174694 Phase 4 Telithromycin
26 Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Acute Sinusitis and Assessment of Quality of Life Completed NCT00147914 Phase 4 Cefdinir (drug);amoxicillin/clavulanate
27 Systemic Corticosteroids in the Perioperative Management of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) Completed NCT02119273 Phase 4 Prednisone;Placebo
28 The Impact Of The Addition Of Budesonide To Low-Pressure, High-Volume Saline Sinus Irrigation For Chronic Rhinosinusitis Completed NCT02696850 Phase 4 Budesonide;Saline alone
29 Xolair in Patients With Chronic Sinusitis Completed NCT00117611 Phase 4 Anti-IgE antibody omalizumab or placebo
30 Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic Rhinosinusitis Completed NCT03086070 Phase 4 Omeprazole 20mg;Placebo oral capsule
31 Study of Asthma and Nasal Steroids Completed NCT01118312 Phase 4 Mometasone Furoate monohydrate
32 Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers Completed NCT00208065 Phase 4 almotriptan or pseudoephedrine
33 Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate Recruiting NCT03431337 Phase 4 Amoxicillin 875 mg
34 The Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis and Recurrent Sinusitis Recruiting NCT02582099 Phase 4 Gentamicin nasal irrigation;Normal saline nasal irrigation
35 Response of the Airway in Sinusitis and Asthma Recruiting NCT03011632 Phase 4 Mometasone Nasal;placebo mometasone
36 Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study Active, not recruiting NCT00841802 Phase 4 Prednisone
37 The Use of Prophylactic Antibiotics in Endoscopy Sinus Surgery for Chronic Rhinosinusitis With or Without Polyp Not yet recruiting NCT03809312 Phase 4 Amoxicillin / Clavulanic acid 875mg / 125mg;Placebos
38 Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis Not yet recruiting NCT03705793 Phase 4 Mometasone Furoate Nasal Irrigation;Mometasone Nasal Spray
39 Use of Perioperative Antibiotics in Endoscopic Sinus Surgery Not yet recruiting NCT03369717 Phase 4 Amoxi Clavulanate
40 Pain Control Following Sinus Surgery Not yet recruiting NCT03783702 Phase 4 OxyCODONE 5 Mg Oral Tablet;Ibuprofen 600 Mg Oral Tablet;Acetaminophen 650 MG Oral Tablet
41 Canadian Health Economics, Outcome, and Effectiveness Comparison of Treatment in Patients With Chronic Rhinosinusitis Terminated NCT01455948 Phase 4
42 Corticosteroid Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) Terminated NCT01676415 Phase 4 Prednisone;Topical mometasone
43 Study of the Use of LUMA Lightwire Terminated NCT00705237 Phase 4
44 Study to Evaluate the Efficacy and Safety of Moxifloxacin Versus Amoxicillin/Clavulanate in the Treatment of Acute Bacterial Rhinosinusitis Terminated NCT00493038 Phase 4 Moxifloxacin (Avelox, BAY12-8039);Amoxicillin/Clavulanate
45 Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis Terminated NCT00245440 Phase 4 Azithromycin;Telithromycin
46 Sinusitis and Facial Pain Disorders Anti-Depression Trial Terminated NCT00754793 Phase 4 escitalopram;placebo
47 Nasospore Stent For Use in Enodscopic Sinus Surgery Withdrawn NCT00671541 Phase 4 Merogel Nasal Stent and Nasopore Stent;Nasopore Stent and either Gentamycin or Bacitracin
48 Effects of Anti-IgE Antibody Omalizumab on Patients With Chronic Sinusitis Withdrawn NCT00603785 Phase 4 Placebo;Xolair
49 The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery Unknown status NCT00852410 Phase 3 1% lidocaine with 1:100,000 adrenaline;1% lidocaine with 1:200,000 adrenaline
50 Effect of Oral Vitamin D3 on Chronic Rhinosinusitis Treatment in Adults With Lower Vitamin D Levels Unknown status NCT02668861 Phase 3 Vitamin D;Budesonide Nasal Spray

Search NIH Clinical Center for Paranasal Sinus Disease

Cochrane evidence based reviews: paranasal sinus diseases

Genetic Tests for Paranasal Sinus Disease

Anatomical Context for Paranasal Sinus Disease

MalaCards organs/tissues related to Paranasal Sinus Disease:

41
Eye, Bone, Lung, Skin, Heart, T Cells, B Cells

Publications for Paranasal Sinus Disease

Articles related to Paranasal Sinus Disease:

(show top 50) (show all 55)
# Title Authors Year
1
Paranasal Sinus Disease in Children With Headache. ( 28831857 )
2017
2
Higher Body Mass Index and Increased Prevalence of Paranasal Sinus Disease. ( 26830349 )
2016
3
Pretransplant paranasal sinus disease is associated with a high incidence of transplant-related mortality in hematopoietic stem cell transplantation for children and adolescents. ( 27748554 )
2016
4
Association between diabetes and increased prevalence of paranasal sinus disease: a cross-sectional study in Japanese adults. ( 25728620 )
2015
5
Nasal Cavity and Paranasal Sinus Diseases Affecting Orbit. ( 26080260 )
2015
6
A stereological study on the correlation of inferior turbinate hypertrophy and paranasal sinus disease. ( 24389985 )
2014
7
Headaches caused by nasal and paranasal sinus disease. ( 24703542 )
2014
8
Prognosis for sixth nerve palsy arising from paranasal sinus disease. ( 24119609 )
2013
9
The impact of a patient's age on the clinical presentation of inflammatory paranasal sinus disease. ( 23702318 )
2013
10
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): ancillary diagnostic findings and involvement of the various sinus compartments. ( 21812807 )
2012
11
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): treatments and long-term results of treatments. ( 21812808 )
2012
12
Ophthalmic manifestations of paranasal sinus disease: a clinical grading system. ( 22411699 )
2012
13
Clinical consensus statement: appropriate use of computed tomography for paranasal sinus disease. ( 23054429 )
2012
14
Complications of nose and paranasal sinus disease. ( 23272436 )
2011
15
Paranasal sinus disease in horses. ( 21870345 )
2011
16
The expression of fibrinolytic components in chronic paranasal sinus disease. ( 21711960 )
2011
17
Thyroid Eye Disease and Paranasal Sinus Disease. ( 20924307 )
2010
18
Paranasal sinus disease and sputum eosinophilia in prednisone-dependent asthma. ( 21144367 )
2010
19
Significance of blood-tinged post-nasal drip in paranasal sinus disease. ( 17888198 )
2008
20
Unilateral paranasal sinus diseases: analysis of the clinical characteristics, diagnosis, pathology, and computed tomography findings. ( 18568494 )
2008
21
Ophthalmological complications of nasal, paranasal sinus diseases and head and neck tumours. ( 17685213 )
2006
22
The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. ( 15502150 )
2004
23
Headaches due to nasal and paranasal sinus disease. ( 15062525 )
2004
24
The role of leukotriene inhibitors in patients with paranasal sinus disease. ( 12923360 )
2003
25
CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. ( 11972457 )
2002
26
Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. ( 11195032 )
2000
27
Optic nerve blindness due to paranasal sinus disease. ( 10420111 )
1999
28
Relative value of MR imaging as compared with CT in the diagnosis of inflammatory paranasal sinus disease. ( 9885603 )
1999
29
[Cytokines and chemokines in paranasal sinus diseases]. ( 10535064 )
1999
30
Use of standard radiography to diagnose paranasal sinus disease of asthmatic children in Taiwan: comparison with computed tomography. ( 10466541 )
1999
31
Imaging of paranasal sinus disease. ( 9168874 )
1997
32
Imaging in paranasal sinus disease. ( 9619203 )
1997
33
Correlation of clinical examination with computer tomography in paranasal sinus disease. ( 9209590 )
1997
34
Paranasal sinus disease in patients with cystic fibrosis. ( 8834282 )
1996
35
Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. ( 8883660 )
1996
36
Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. ( 8560170 )
1995
37
Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. ( 8049050 )
1994
38
Effect of a topical vasoconstrictor on computed tomography of paranasal sinus disease. ( 8421421 )
1993
39
Endoscopic examination and treatment of paranasal sinus disease in 16 horses. ( 8116208 )
1993
40
The prevalence of paranasal sinus disease in HIV infection and AIDS on cranial MR imaging. ( 8472478 )
1993
41
Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. ( 8372929 )
1993
42
Paranasal sinus disease in HIV antibody positive patients. ( 8335314 )
1993
43
Limited-slice CT in the evaluation of paranasal sinus disease in children. ( 1898816 )
1991
44
Paranasal sinus disease with intracranial extension: aspergillosis versus malignancy. ( 3131605 )
1988
45
Magnetic resonance imaging in the evaluation of nose and paranasal sinus disease. ( 3479224 )
1987
46
Computed tomography in nasal and paranasal sinus disease. ( 6482629 )
1984
47
Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. ( 7451769 )
1981
48
Paranasal sinus diseases. ( 6783245 )
1981
49
Diagnostic ultrasonography in paranasal sinus diseases. A 5-year review. ( 573431 )
1979
50
Acidic glycosaminoglycans in the ground substance in paranasal sinus diseases. ( 920146 )
1977

Variations for Paranasal Sinus Disease

Expression for Paranasal Sinus Disease

Search GEO for disease gene expression data for Paranasal Sinus Disease.

Pathways for Paranasal Sinus Disease

Pathways related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 ALOX5 GATA3 IFNG IL10 IL13 IL17A
2
Show member pathways
13.64 ALOX5 IFNG IL10 IL13 IL17A IL4
3
Show member pathways
13.48 IFNG IL10 IL13 IL17A IL4 IL5
4
Show member pathways
13.32 ALOX5 GATA3 IFNG IL10 IL13 IL17A
5
Show member pathways
13.26 GATA3 IL5 PLAU PLAUR SERPINE1 TGFB1
6
Show member pathways
13.26 FLNC IL10 IL13 IL17A IL4 IL5
7
Show member pathways
12.86 IFNG IL10 IL13 IL17A IL4 IL5
8 12.8 IFNG IL13 IL4 IL5 TGFB1
9
Show member pathways
12.6 GATA3 IFNG IL10 IL13 IL17A IL4
10 12.56 ALOX5 GATA3 IFNG IL10 IL17A IL4
11
Show member pathways
12.53 ALOX5 IL13 IL4 IL5
12
Show member pathways
12.43 GATA3 IFNG IL10 IL17A IL4 IL5
13
Show member pathways
12.41 IFNG IL10 IL13 IL4 IL5
14
Show member pathways
12.35 IFNG IL13 IL17A IL4 IL5 MUC5B
15
Show member pathways
12.31 ALOX5 IFNG IL4 SERPINE1
16 12.27 FLNC PLAU PLAUR TGFB1
17
Show member pathways
12.27 ALOX5 IFNG IL10 IL4 TGFB1
18
Show member pathways
12.25 IFNG IL10 IL13 IL17A IL4 IL5
19
Show member pathways
12.07 IFNG IL10 IL13 IL17A IL4 IL5
20
Show member pathways
12.06 GATA3 IFNG IL10 IL17A TGFB1
21 12 GATA3 SERPINE1 TGFB1
22 12 IFNG IL10 IL4 IL5
23
Show member pathways
11.98 IFNG IL13 IL4
24 11.96 IFNG IL4 TGFB1
25 11.95 IFNG PLAU SERPINE1 TGFB1
26 11.92 ALOX5 GATA3 IL10 IL13 IL17A IL4
27 11.85 IFNG IL10 TGFB1
28 11.84 GATA3 IFNG IL13 IL4 IL5
29 11.82 IFNG IL17A TGFB1
30 11.8 GATA3 IL10 IL5 SERPINE1
31 11.79 IFNG NODAL TGFB1
32
Show member pathways
11.79 GATA3 IFNG IL4 IL5
33 11.73 IFNG IL10 TGFB1
34 11.73 IFNG IL10 IL13 IL17A IL4 TGFB1
35 11.65 IL10 IL4 IL5
36 11.64 IL13 IL4 IL5 MUC5B PLAU TGFB1
37 11.63 PLAU PLAUR SERPINE1
38 11.61 IFNG SERPINE1 TGFB1
39 11.6 GATA3 IFNG IL10 IL13 IL17A IL4
40 11.53 IL10 IL13 IL4
41 11.52 IFNG IL10 TGFB1
42 11.4 GATA3 IFNG IL10 IL13 IL4 IL5
43 11.34 IFNG IL4 IL5
44 11.26 IFNG IL13 TGFB1
45 11.25 IFNG IL10 IL13 IL4 IL5
46 11.22 IL10 IL13 IL17A IL4 IL5
47 11.01 IL10 IL13 IL17A IL4 IL5 TGFB1
48 10.94 GATA3 IFNG IL13 IL17A IL4 IL5
49 10.87 PLAU PLAUR SERPINE1
50 10.56 IFNG IL10 IL13 IL4 IL5 TGFB1

GO Terms for Paranasal Sinus Disease

Cellular components related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 ALOX5 IFNG IL10 IL13 IL17A IL4
2 extracellular region GO:0005576 9.44 ALOX5 IFNG IL10 IL13 IL17A IL4

Biological processes related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.92 GATA3 IFNG IL13 IL4 TGFB1
2 immune response GO:0006955 9.85 IFNG IL10 IL13 IL17A IL4 IL5
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.78 IL10 IL5 NODAL
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 IFNG IL13 IL4
5 inflammatory response GO:0006954 9.73 ALOX5 IL10 IL13 IL17A IL5 TGFB1
6 cell development GO:0048468 9.71 GATA3 NODAL TGFB1
7 positive regulation of osteoclast differentiation GO:0045672 9.64 IFNG IL17A
8 positive regulation of T cell differentiation GO:0045582 9.63 GATA3 IL4
9 myeloid dendritic cell differentiation GO:0043011 9.63 IL4 TGFB1
10 positive regulation of macrophage activation GO:0043032 9.62 IL10 IL13
11 positive regulation of transcription regulatory region DNA binding GO:2000679 9.62 GATA3 TGFB1
12 regulation of regulatory T cell differentiation GO:0045589 9.61 IFNG TGFB1
13 positive regulation of B cell proliferation GO:0030890 9.61 IL13 IL4 IL5
14 cell activation GO:0001775 9.59 GATA3 TGFB1
15 negative regulation of interleukin-17 production GO:0032700 9.58 IFNG TGFB1
16 positive regulation of SMAD protein signal transduction GO:0060391 9.58 NODAL TGFB1
17 positive regulation of interleukin-13 production GO:0032736 9.57 GATA3 IL4
18 cytokine-mediated signaling pathway GO:0019221 9.56 ALOX5 GATA3 IL10 IL13 IL17A IL4
19 positive regulation of MHC class II biosynthetic process GO:0045348 9.55 IL10 IL4
20 negative regulation of endothelial cell apoptotic process GO:2000352 9.55 GATA3 IL10 IL13 IL4 SERPINE1
21 positive regulation of interleukin-23 production GO:0032747 9.51 IFNG IL17A
22 fibrinolysis GO:0042730 9.5 PLAU PLAUR SERPINE1
23 regulation of isotype switching GO:0045191 9.49 IL10 IL4
24 type 2 immune response GO:0042092 9.48 IL10 IL4
25 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL13 IL4
26 regulation of signaling receptor activity GO:0010469 9.32 IFNG IL10 IL13 IL17A IL4 IL5
27 positive regulation of transcription, DNA-templated GO:0045893 10 GATA3 IL10 IL4 IL5 TGFB1
28 positive regulation of transcription by RNA polymerase II GO:0045944 10 GATA3 IL10 IL17A IL4 NODAL SERPINE1

Molecular functions related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 IL10 IL4 IL5 NODAL TGFB1
2 cytokine activity GO:0005125 9.23 IFNG IL10 IL13 IL17A IL4 IL5
3 protein binding GO:0005515 10.03 ALOX5 FLNC GATA3 IFNG IL10 IL13

Sources for Paranasal Sinus Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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