MCID: PRN002
MIFTS: 25

Paranasal Sinus Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Respiratory diseases

Aliases & Classifications for Paranasal Sinus Lymphoma

MalaCards integrated aliases for Paranasal Sinus Lymphoma:

Name: Paranasal Sinus Lymphoma 12 15 71
Lymphoma of Accessory Sinus 12
Lymphoma of Paranasal Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1355
NCIt 49 C6068
UMLS 71 C1335339

Summaries for Paranasal Sinus Lymphoma

MalaCards based summary : Paranasal Sinus Lymphoma, also known as lymphoma of accessory sinus, is related to lymphoma and diffuse large b-cell lymphoma. An important gene associated with Paranasal Sinus Lymphoma is SCYL1 (SCY1 Like Pseudokinase 1), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. Affiliated tissues include b cells, t cells and breast, and related phenotypes are hematopoietic system and immune system

Related Diseases for Paranasal Sinus Lymphoma

Diseases related to Paranasal Sinus Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 lymphoma 28.9 TNFRSF8 PAX5 CSF3 BCL6
2 diffuse large b-cell lymphoma 27.9 TNFRSF8 PAX5 CSF3 CD79A BCL6
3 vulvar dystrophy 10.3 SERPINB3 ACOT13
4 cervical large cell neuroendocrine carcinoma 10.3 TAGLN CNN1
5 lung oat cell carcinoma 10.2 TAGLN CNN1
6 laryngeal small cell carcinoma 10.2 TAGLN CNN1
7 corneal dystrophy, subepithelial mucinous 10.2 TAGLN CNN1
8 b-cell lymphoma 10.1
9 selective igg deficiency disease 10.1 PAX5 CD79A
10 monoclonal paraproteinemia 10.1 PAX5 CD79A
11 osteogenic sarcoma 10.0
12 yemenite deaf-blind hypopigmentation syndrome 10.0
13 rare tumor 10.0
14 bladder lymphoma 10.0 CD79A BCL6
15 lethal midline granuloma 9.9 TNFRSF8 SCYL1
16 small intestine lymphoma 9.9 CD79A BCL6
17 prostate lymphoma 9.9 CD79A BCL6
18 epiglottis neoplasm 9.9 CD79A BCL6
19 liver lymphoma 9.9 CD79A BCL6
20 colon lymphoma 9.9 CD79A BCL6
21 primary cutaneous b-cell lymphoma 9.9 PAX5 BCL6
22 primary central nervous system lymphoma 9.9 PAX5 BCL6
23 intraocular lymphoma 9.9 PAX5 BCL6
24 submandibular adenitis 9.9 TNFRSF8 PAX5
25 breast osteosarcoma 9.9 CD79A BCL6
26 breast lipoma 9.8 TNFRSF8 PAX5
27 cryptosporidiosis 9.8 CSF3 CD79A
28 nodal marginal zone lymphoma 9.8 CD79A BCL6
29 myeloid sarcoma 9.8 PAX5 CD79A
30 appendix lymphoma 9.8 TNFRSF8 PAX5
31 gastric lymphoma 9.8 CD79A BCL6
32 infected hydrocele 9.8 TNFRSF8 CD79A
33 cerebral lymphoma 9.7 TNFRSF8 CD79A
34 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.7 TNFRSF8 BCL6
35 t-cell/histiocyte rich large b cell lymphoma 9.7 TNFRSF8 BCL6
36 scabies 9.7 TNFRSF8 CSF3
37 pleural empyema 9.7 TNFRSF8 CD79A
38 lymphosarcoma 9.7 TNFRSF8 BCL6
39 acute leukemia 9.7 PAX5 MLLT1 CSF3
40 autoimmune lymphoproliferative syndrome, type v 9.6 TNFRSF8 BCL6
41 spinal cord lymphoma 9.6 PAX5 CD79A BCL6
42 cll/sll 9.6 PAX5 CD79A BCL6
43 multicentric castleman disease 9.6 PAX5 CD79A BCL6
44 castleman disease 9.6 PAX5 CSF3 BCL6
45 splenic marginal zone lymphoma 9.6 PAX5 BCL6
46 adult acute lymphocytic leukemia 9.6 TNFRSF8 CSF3
47 mediastinal malignant lymphoma 9.5 TNFRSF8 PAX5 CD79A
48 mediastinal gray zone lymphoma 9.5 TNFRSF8 PAX5 CD79A
49 hodgkin's lymphoma, mixed cellularity 9.5 TNFRSF8 PAX5 CD79A
50 hodgkin's lymphoma, lymphocytic depletion 9.5 TNFRSF8 PAX5 CD79A

Graphical network of the top 20 diseases related to Paranasal Sinus Lymphoma:



Diseases related to Paranasal Sinus Lymphoma

Symptoms & Phenotypes for Paranasal Sinus Lymphoma

MGI Mouse Phenotypes related to Paranasal Sinus Lymphoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 BCL6 CD79A CSF3 MLLT1 NT5C2 PAX5
2 immune system MP:0005387 9.56 BCL6 CD79A CSF3 MLLT1 PAX5 SCYL1
3 normal MP:0002873 9.1 BCL6 CD79A MLLT1 NT5C2 PAX5 TAGLN

Drugs & Therapeutics for Paranasal Sinus Lymphoma

Search Clinical Trials , NIH Clinical Center for Paranasal Sinus Lymphoma

Genetic Tests for Paranasal Sinus Lymphoma

Anatomical Context for Paranasal Sinus Lymphoma

MalaCards organs/tissues related to Paranasal Sinus Lymphoma:

40
B Cells, T Cells, Breast, Lung, Myeloid, Skeletal Muscle, Bone

Publications for Paranasal Sinus Lymphoma

Articles related to Paranasal Sinus Lymphoma:

(show all 15)
# Title Authors PMID Year
1
Late Central Nervous System Relapse in a Patient with Maxillary Sinus Lymphoma. 61
30820366 2018
2
Paranasal sinus lymphoma: Retrospective review with focus on clinical features, histopathology, prognosis, and relationship to systemic lymphoma. 61
28339134 2017
3
Primary diffuse large B-cell non-Hodgkin lymphoma of the paranasal sinuses presenting as cavernous sinus syndrome. 61
25006937 2014
4
Primary diffuse large B-cell lymphoma of the ethmoido-orbital region. 61
24220479 2013
5
Secondary intraocular uveal involvement by primary paranasal sinus lymphoma. 61
22581320 2012
6
Radiation therapy communication: nasal passage and paranasal sinus lymphoma in a pony. 61
20166403 2010
7
[Primary non-Hodgkin's lymphoma of the paranasal sinuses: a report of 14 cases]. 61
17697560 2007
8
Orbital invasion of frontal sinus lymphoma. 61
16754228 2006
9
Primary paranasal sinus lymphoma: natural history and improved outcome with central nervous system chemoprophylaxis. 61
16263574 2005
10
Isolated skeletal muscle recurrence of the paranasal sinus lymphoma in complete remission. 61
16110142 2005
11
Treatment of lethal midline granuloma type nasal T-cell lymphoma. 61
9208902 1997
12
[Primary non-Hodgkin's lymphoma of the maxillary sinus]. 61
9489389 1997
13
Brief chemotherapy, involved field radiation therapy, and central nervous system prophylaxis for paranasal sinus lymphoma. 61
1375527 1992
14
Optic neuropathy associated with chronic lymphomatous meningitis. 61
2972750 1988
15
Non-Hodgkin's lymphomas of head and neck extranodal sites. 61
3882644 1985

Variations for Paranasal Sinus Lymphoma

Expression for Paranasal Sinus Lymphoma

Search GEO for disease gene expression data for Paranasal Sinus Lymphoma.

Pathways for Paranasal Sinus Lymphoma

Pathways related to Paranasal Sinus Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 TNFRSF8 PAX5 CD79A BCL6
2 11.6 PAX5 MLLT1 BCL6
3 10.52 TNFRSF8 PAX5 BCL6

GO Terms for Paranasal Sinus Lymphoma

Sources for Paranasal Sinus Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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