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MCID: PRN032
MIFTS: 25

Paraneoplastic Cerebellar Degeneration

Categories: Cancer diseases, Immune diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes
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Aliases & Classifications for Paraneoplastic Cerebellar Degeneration

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MalaCards integrated aliases for Paraneoplastic Cerebellar Degeneration:

Name: Paraneoplastic Cerebellar Degeneration 20 54 71

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Respiratory diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 71 C0393534
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Summaries for Paraneoplastic Cerebellar Degeneration

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GARD : 20 Paraneoplastic syndromes are a group of rare disorders that include paraneoplastic cerebellar degeneration (PCD). Paraneoplastic syndromes are thought to result from an abnormal immune response to an underlying (and often undetected) malignant tumor. PCD is a rare, non-metastatic complication of cancer. PCD is typically thought to be caused by antibodies generated against tumor cells. Instead of just attacking the cancer cells, the cancer-fighting antibodies also attack normal cells in the cerebellum. PCD occurs most often in individuals with the following cancers: ovarian cancer, cancer of the uterus, breast cancer, small-cell lung cancer, and Hodgkin lymphoma. Symptoms of PCD may include dizziness, loss of coordination, blurred vision, nystagmus, ataxia, and speech difficulties.

MalaCards based summary : Paraneoplastic Cerebellar Degeneration is related to cerebellar degeneration and paraneoplastic neurologic disorders, and has symptoms including cerebellar ataxia An important gene associated with Paraneoplastic Cerebellar Degeneration is CDR2 (Cerebellar Degeneration Related Protein 2). Affiliated tissues include cerebellum, uterus and t cells.

Wikipedia : 74 Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic syndrome associated with a broad... more...

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Related Diseases for Paraneoplastic Cerebellar Degeneration

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Diseases related to Paraneoplastic Cerebellar Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 cerebellar degeneration 32.1 CDR2 CDR1
2 paraneoplastic neurologic disorders 11.3
3 subacute cerebellar degeneration 11.2
4 ataxia and polyneuropathy, adult-onset 10.9
5 pathologic nystagmus 10.7
6 paraneoplastic syndromes 10.6
7 ovarian cancer 10.6
8 lambert-eaton myasthenic syndrome 10.5
9 small cell carcinoma 10.5
10 tremor 10.5
11 ovary adenocarcinoma 10.4
12 lymphoma, hodgkin, classic 10.4
13 limbic encephalitis 10.4
14 adenocarcinoma 10.4
15 dysphagia 10.4
16 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
17 fallopian tube adenocarcinoma 10.3
18 encephalitis 10.3
19 small cell cancer of the lung 10.3
20 diffuse large b-cell lymphoma 10.3
21 lymphoma 10.3
22 gastric adenocarcinoma 10.3
23 b-cell lymphoma 10.3
24 bladder cancer 10.3
25 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.3
26 myoclonus 10.3
27 autoimmune disease 10.2
28 breast cancer 10.2
29 endometrial cancer 10.2
30 neuroendocrine carcinoma 10.2
31 melanoma 10.2
32 fallopian tube carcinoma 10.2
33 papillomatosis, confluent and reticulated 10.1
34 myeloma, multiple 10.1
35 follicular lymphoma 10.1
36 ptosis 10.1
37 combined immunodeficiency 10.1
38 nephrotic syndrome 10.1
39 sensory peripheral neuropathy 10.1
40 cerebellar disease 10.1
41 papillary carcinoma 10.1
42 serous cystadenocarcinoma 10.1
43 merkel cell carcinoma 10.1
44 lymphoepithelioma-like carcinoma 10.1
45 severe combined immunodeficiency 10.1
46 dysautonomia 10.1
47 thyroid carcinoma 10.1
48 major affective disorder 1 10.0
49 multiple sclerosis 10.0
50 renal cell carcinoma, nonpapillary 10.0

Graphical network of the top 20 diseases related to Paraneoplastic Cerebellar Degeneration:



Diseases related to Paraneoplastic Cerebellar Degeneration
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Symptoms & Phenotypes for Paraneoplastic Cerebellar Degeneration

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UMLS symptoms related to Paraneoplastic Cerebellar Degeneration:


cerebellar ataxia
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Drugs & Therapeutics for Paraneoplastic Cerebellar Degeneration

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Collection of Biological Samples From Patients With Rare Neurological Diseases Recruiting NCT04698421

Search NIH Clinical Center for Paraneoplastic Cerebellar Degeneration

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Genetic Tests for Paraneoplastic Cerebellar Degeneration

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Anatomical Context for Paraneoplastic Cerebellar Degeneration

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MalaCards organs/tissues related to Paraneoplastic Cerebellar Degeneration:

40
Cerebellum, Uterus, T Cells, Prostate, Eye, Colon, Ovary
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Publications for Paraneoplastic Cerebellar Degeneration

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Articles related to Paraneoplastic Cerebellar Degeneration:

(show top 50) (show all 532)
# Title Authors PMID Year
1
Functional analysis of CD8+ T cell responses to the onconeural self protein cdr2 in patients with paraneoplastic cerebellar degeneration. 61 54
18053582 2008
2
Induction of cytotoxic T lymphocytes specific for paraneoplastic cerebellar degeneration-associated antigen in vivo by DNA immunization. 61 54
11771954 2001
3
Cytotoxic T cell activity against the peptide, AYRARALEL, from Yo protein of patients with the HLA A24 or B27 supertype and paraneoplastic cerebellar degeneration. 54 61
11489286 2001
4
Cdr2, a target antigen of naturally occuring human tumor immunity, is widely expressed in gynecological tumors. 61 54
10786675 2000
5
Cytotoxic T cells against a peptide of Yo protein in patients with paraneoplastic cerebellar degeneration and anti-Yo antibody. 61 54
10500270 1999
6
The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival. 54 61
10465786 1999
7
Cytotoxic T cells react with recombinant Yo protein from a patient with paraneoplastic cerebellar degeneration and anti-Yo antibody. 61 54
9879687 1998
8
Failure to detect cytotoxic T cell activity against recombinant Yo protein using autologous dendritic cells as the target in a patient with paraneoplastic cerebellar degeneration and anti-Yo antibody. 54 61
9527904 1998
9
Expression of messenger RNA encoding a paraneoplastic cerebellar degeneration-associated antigen in the rat hippocampus. 61 54
8545049 1995
10
Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody. 2. Passive transfer of murine mononuclear cells activated with recombinant Yo protein to paraneoplastic cerebellar degeneration lymphocytes in severe combined immunodeficiency mice. 54 61
7788964 1995
11
Paraneoplastic Cerebellar Degeneration: The Importance of Including CDR2L as a Diagnostic Marker. 61
33531379 2021
12
Paraneoplastic cerebellar degeneration as a presenting manifestation of non-Hodgkin's lymphoma. 61
33555484 2021
13
Acute-onset paraneoplastic cerebellar degeneration secondary to neuroendocrine carcinoma with atypical prognosis: a case report. 61
33583245 2021
14
Paraneoplastic cerebellar degeneration associated with anti-Yo antibodies in an ovarian cancer case: A case report. 61
33490355 2021
15
A Rare Coexistence of Paraneoplastic Cerebellar Degeneration: Papillary Thyroid Carcinoma. 61
33477892 2021
16
Immune-Mediated Cerebellar Ataxias: Clinical Diagnosis and Treatment Based on Immunological and Physiological Mechanisms. 61
33423437 2021
17
Imaging Review of Paraneoplastic Neurologic Syndromes. 61
33093137 2020
18
Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies. 61
33328403 2020
19
Potential effect of intravenous immunoglobulin against paraneoplastic cerebellar degeneration in progressive ovarian cancer. 61
33005721 2020
20
Localization of CDR2L and CDR2 in paraneoplastic cerebellar degeneration. 61
33009713 2020
21
Breast cancer associated with paraneoplastic cerebellar degeneration: A case series. 61
33078760 2020
22
Treatment of Primary Autoimmune Cerebellar Ataxia with Mycophenolate. 61
32524518 2020
23
Anti-SOX1 Antibodies in Paraneoplastic Neurological Syndrome. 61
33029958 2020
24
Paraneoplastic Neurological Syndromes: Study of Prevalence in a Province of the Lombardy Region, Italy. 61
32993010 2020
25
Anti-Ma-associated paraneoplastic cerebellar degeneration in a patient with nodular lymphocyte-predominant Hodgkin lymphoma: a case report. 61
32967629 2020
26
Paraneoplastic cerebellar degeneration associated with anti-protein kinase Cgamma antibodies in a Chinese patient. 61
33217719 2020
27
CDR2 and CDR2L Yo Antigens in Paraneoplastic Cerebellar Degeneration. 61
32445212 2020
28
Reply to "CDR2 and CDR2L Yo Antigens in Paraneoplastic Cerebellar Degeneration". 61
32445220 2020
29
Paraneoplastic cerebellar degeneration diagnosed by anti-Yo determination in a young woman with early breast cancer. 61
32843422 2020
30
Paraneoplastic cerebellar degeneration heralding recurrence of fallopian tube adenocarcinoma: A case report and literature review. 61
32904367 2020
31
[Preliminary analysis of central paroxysmal positional vertigo]. 61
32791773 2020
32
Plasma exchange for treating anti-Yo-associated paraneoplastic cerebellar degeneration: Case report and literature review. 61
32872070 2020
33
Paraneoplastic encephalitis with leukoencephalopathy in primary fallopian tube carcinoma. 61
32395191 2020
34
Paraneoplastic cerebellar degeneration in a patient with breast cancer associated with carbonic anhydrase-related protein VIII autoantibodies. 61
32325285 2020
35
A Case of Paraneoplastic Cerebellar Degeneration that Preceded the Diagnosis of Classical Hodgkin's Lymphoma by 16 Months. 61
32574156 2020
36
Paraneoplastic Cerebellar Degeneration in Diffuse Large B-cell Lymphoma and Review of Associated Onconeural Antibodies. 61
32171690 2020
37
Paraneoplastic Cerebellar Degeneration Secondary to BRAF Mutant Melanoma Metastasis from an Occult Primary Cancer. 61
32774248 2020
38
Non-small cell lung cancer associated with late-onset Lambert-Eaton myasthenic syndrome and paraneoplastic cerebellar degeneration. 61
31735997 2020
39
Rhombencephalitis associated with isolated Zic4-antibodies in Paraneoplastic cerebellar degeneration: a case report. 61
32450842 2020
40
Tremor in Paraneoplastic Cerebellar Degeneration: Beyond Intention Tremor. 61
32606537 2020
41
Paraneoplastic cerebellar degeneration: initial presentation of mucosa-associated lymphoid tissue lymphoma in a patient with primary Sjögren's syndrome. 61
32187048 2020
42
[Ataxia - a group of heterogeneous diseases]. 61
32154899 2020
43
[Vertigo as the first manifestation of ovarian cancer]. 61
32186813 2020
44
Immunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications. 61
32655545 2020
45
Antinuclear antibodies (ANA) patterns in paraneoplastic cerebellar degeneration during the course of disease and treatment protocols - A case report. 61
32743519 2020
46
Combined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic Malignancy. 61
31970005 2020
47
Paraneoplastic Cerebellar Degeneration in Nasopharyngeal Carcinoma: a Unique Association. 61
31161534 2019
48
Stroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature. 61
31463826 2019
49
Cerebellar Hypermetabolism in a Case of Paraneoplastic Cerebellar Syndrome With the Primary Lymphoepithelial Carcinoma in Tonsil. 61
31162262 2019
50
Rare case of paraneoplastic cerebellar degeneration secondary to high-grade serous carcinoma of tubo-ovarian origin. 61
31466977 2019
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Variations for Paraneoplastic Cerebellar Degeneration

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Expression for Paraneoplastic Cerebellar Degeneration

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Search GEO for disease gene expression data for Paraneoplastic Cerebellar Degeneration.
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Pathways for Paraneoplastic Cerebellar Degeneration

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GO Terms for Paraneoplastic Cerebellar Degeneration

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Sources for Paraneoplastic Cerebellar Degeneration

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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