MCID: PRN032
MIFTS: 33

Paraneoplastic Cerebellar Degeneration

Categories: Rare diseases

Aliases & Classifications for Paraneoplastic Cerebellar Degeneration

MalaCards integrated aliases for Paraneoplastic Cerebellar Degeneration:

Name: Paraneoplastic Cerebellar Degeneration 53 55 73

Classifications:



External Ids:

UMLS 73 C0393534

Summaries for Paraneoplastic Cerebellar Degeneration

NIH Rare Diseases : 53 Paraneoplastic syndromes are a group of rare disorders that include paraneoplastic cerebellar degeneration (PCD). Paraneoplastic syndromes are thought to result from an abnormal immune response to an underlying (and often undetected) malignant tumor. PCD is a rare, non-metastatic complication of cancer. PCD is typically thought to be caused by antibodies generated against tumor cells. Instead of just attacking the cancer cells, the cancer-fighting antibodies also attack normal cells in the cerebellum. PCD occurs most often in individuals with the following cancers: ovarian cancer, cancer of the uterus, breast cancer, small-cell lung cancer, and Hodgkin lymphoma. Symptoms of PCD may include dizziness, loss of coordination, blurred vision, nystagmus, ataxia, and speech difficulties.

MalaCards based summary : Paraneoplastic Cerebellar Degeneration is related to cerebellar degeneration and limbic encephalitis, and has symptoms including cerebellar ataxia An important gene associated with Paraneoplastic Cerebellar Degeneration is CDR2 (Cerebellar Degeneration Related Protein 2). The drugs Tacrolimus and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lung, uterus and cerebellum, and related phenotype is behavior/neurological.

Wikipedia : 76 Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic syndrome associated with a broad... more...

Related Diseases for Paraneoplastic Cerebellar Degeneration

Diseases related to Paraneoplastic Cerebellar Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 cerebellar degeneration 32.3 CACNA1A CDR1 CDR2
2 limbic encephalitis 29.9 AMPH ELAVL3
3 small cell cancer of the lung 29.0 ELAVL4 ENO2 GRP
4 subacute cerebellar degeneration 11.1
5 pleomorphic adenoma carcinoma 10.5 ENO2 ERBB2
6 lymphoma 10.4
7 adenocarcinoma 10.3
8 mixed cell type cancer 10.3 ENO2 ERBB2
9 ovarian cancer 10.3
10 breast cancer 10.3
11 neuronitis 10.3
12 urinary bladder small cell neuroendocrine carcinoma 10.3 ENO2 GRP
13 adenosquamous cell lung carcinoma 10.2 ENO2 ERBB2
14 ovarian cancer 1 10.2
15 lung meningioma 10.2 ENO2 GRP
16 lung cancer 10.2
17 lambert-eaton myasthenic syndrome 10.1
18 duodenal gastrinoma 10.1 ENO2 GRP
19 fallopian tube adenocarcinoma 10.0
20 b-cell lymphomas 10.0
21 prostatitis 10.0
22 diffuse large b-cell lymphoma 10.0
23 squamous cell carcinoma 10.0
24 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.0
25 encephalitis 10.0
26 lymphoma, hodgkin, classic 10.0
27 paraneoplastic neurologic disorders 9.9 ELAVL4 ZIC1
28 myeloma, multiple 9.9
29 combined immunodeficiency, x-linked 9.9
30 suppression of tumorigenicity 12 9.9
31 merkel cell carcinoma 9.9
32 endometrial cancer 9.9
33 nephrotic syndrome 9.9
34 severe combined immunodeficiency 9.9
35 respiratory system cancer 9.9 ENO2 ERBB2 GRP
36 diffuse pulmonary fibrosis 9.9 ENO2 GRP
37 ovarian clear cell carcinoma 9.8
38 liposarcoma 9.8
39 pseudobulbar affect 9.8
40 pseudomyxoma peritonei 9.8
41 marantic endocarditis 9.8
42 paraneoplastic syndromes 9.8
43 aceruloplasminemia 9.8
44 dermatomyositis 9.8
45 gastric adenocarcinoma 9.8
46 tremor 9.8
47 endocarditis 9.8
48 tonsillitis 9.8
49 bladder urothelial carcinoma 9.8
50 ataxia-oculomotor apraxia 3 9.8

Graphical network of the top 20 diseases related to Paraneoplastic Cerebellar Degeneration:



Diseases related to Paraneoplastic Cerebellar Degeneration

Symptoms & Phenotypes for Paraneoplastic Cerebellar Degeneration

UMLS symptoms related to Paraneoplastic Cerebellar Degeneration:


cerebellar ataxia

MGI Mouse Phenotypes related to Paraneoplastic Cerebellar Degeneration:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.32 AMPH CA8 CACNA1A ELAVL3 ELAVL4 ENO2

Drugs & Therapeutics for Paraneoplastic Cerebellar Degeneration

Drugs for Paraneoplastic Cerebellar Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Not Applicable 104987-11-3 445643 439492
2
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
3 Immunosuppressive Agents Not Applicable
4 Calcineurin Inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Not Applicable Tacrolimus

Search NIH Clinical Center for Paraneoplastic Cerebellar Degeneration

Genetic Tests for Paraneoplastic Cerebellar Degeneration

Anatomical Context for Paraneoplastic Cerebellar Degeneration

MalaCards organs/tissues related to Paraneoplastic Cerebellar Degeneration:

41
Lung, Uterus, Cerebellum, T Cells, Brain, B Cells, Prostate

Publications for Paraneoplastic Cerebellar Degeneration

Articles related to Paraneoplastic Cerebellar Degeneration:

(show top 50) (show all 271)
# Title Authors Year
1
Anti-Yo associated paraneoplastic cerebellar degeneration presenting as an acute cerebellitis with posterior cranial fossa hypertension. ( 29378343 )
2018
2
Genetic alterations and tumor immune attack in Yo paraneoplastic cerebellar degeneration. ( 29299667 )
2018
3
Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome Associated with Neuroendocrine Carcinoma of the Oropharynx. ( 29093415 )
2018
4
Paraneoplastic cerebellar degeneration with bilateral facial palsy: a rare primary presentation of breast cancer. ( 29930189 )
2018
5
Anti-ZIC4 associated paraneoplastic cerebellar degeneration in a patient with both diffuse large B-cell lymphoma and incidental smoldering multiple myeloma. ( 29249374 )
2018
6
Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. ( 29679372 )
2018
7
Transcriptomic immune profiling of ovarian cancers in paraneoplastic cerebellar degeneration associated with anti-Yo antibodies. ( 29899393 )
2018
8
Paraneoplastic cerebellar degeneration associated with cerebellar hypermetabolism: Case report. ( 29901574 )
2018
9
Paraneoplastic cerebellar degeneration in a patient with anaplastic non-Hodgkin's lymphoma. ( 29909387 )
2018
10
Paraneoplastic cerebellar degeneration in a patient with a primary fallopian tube adenocarcinoma. A case report and brief review. ( 28386581 )
2017
11
Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer. ( 28377827 )
2017
12
Anti-Yo positive paraneoplastic cerebellar degeneration in the setting of cholangiocarcinoma. ( 27816258 )
2017
13
Paraneoplastic Cerebellar Degeneration Associated with Pelvic Liposarcoma: A Rare Case Report. ( 28092914 )
2017
14
Adult Onset Sporadic Cerebellar Ataxia in Singapore: Diagnostic Outcomes of Paraneoplastic Antibody Testing and Early Clinical Features of Paraneoplastic Cerebellar Degeneration. ( 28417137 )
2017
15
Anti-Yo positive and late-onset paraneoplastic cerebellar degeneration associated with ovarian carcinoma: A case report. ( 28796031 )
2017
16
Paraneoplastic cerebellar degeneration secondary to ovarian carcinosarcoma: a cerebellar conundrum. ( 28790096 )
2017
17
Rehabilitation for a patient with anti-Yo antibody-positive paraneoplastic cerebellar degeneration caused by breast cancer: A case report and literature review. ( 29095299 )
2017
18
A Rare Clinical Entity in Bladder Cancer: Paraneoplastic Cerebellar Degeneration. ( 28506560 )
2017
19
Paraneoplastic cerebellar degeneration associated with anti-ITPR1 antibodies. ( 28203616 )
2017
20
An uncommon manifestation of paraneoplastic cerebellar degeneration in a patient with high grade urothelial, carcinoma with squamous differentiation: A case report and literature review. ( 27209351 )
2016
21
Paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenia in a patient with Merkel cell carcinoma and voltage-gated calcium channel antibodies. ( 28006860 )
2016
22
Paraneoplastic cerebellar degeneration as a marker of endometrial cancer recurrence. ( 27194676 )
2016
23
Hodgkin's lymphoma associated with paraneoplastic cerebellar degeneration in children: a case report and review of the literature. ( 27796550 )
2016
24
Autoimmune neurological syndromes associated limbic encephalitis and paraneoplastic cerebellar degeneration. ( 27592059 )
2016
25
Paraneoplastic cerebellar degeneration and endometrial cancer: a rare occurrence. ( 27020505 )
2016
26
Paraneoplastic cerebellar degeneration with anti-Yo antibodies - a review. ( 27606347 )
2016
27
A case of slowly progressive anti-Yo-associated paraneoplastic cerebellar degeneration successfully treated with antitumor and immunotherapy. ( 27356731 )
2016
28
Anti-Ri antibody-mediated paraneoplastic cerebellar degeneration: A rare, treatable yet poorly recognized entity. ( 27625249 )
2016
29
Restoring Balance: Paraneoplastic Cerebellar Degeneration. ( 27816447 )
2016
30
Paraneoplastic Cerebellar Degeneration-A Rare Presentation of Ovarian Malignancy. ( 27803545 )
2016
31
Standardized test for anti-Tr/DNER in patients with paraneoplastic cerebellar degeneration. ( 25745634 )
2015
32
Paraneoplastic cerebellar degeneration and dermatomyositis as first manifestations of underlying breast malignancy: a report of two cases and a brief review of the subject. ( 26366356 )
2015
33
Plasticity-related gene 5: A novel surface autoantigen in paraneoplastic cerebellar degeneration. ( 26445730 )
2015
34
Paraneoplastic cerebellar degeneration as an early sign of classical Hodgkin lymphoma. ( 26542148 )
2015
35
Anti-Hu Antibody Associated Paraneoplastic Cerebellar Degeneration in Head and Neck Cancer. ( 26694863 )
2015
36
Paraneoplastic cerebellar degeneration associated with small cell neuroendocrine mediastinal carcinoma. ( 26026691 )
2015
37
A Rare Case of Ovarian Cancer Presenting with Paraneoplastic Cerebellar Degeneration and Limbic Encephalitis. ( 26415811 )
2015
38
Paraneoplastic cerebellar degeneration with anti-CV2/CRMP5 antibodies and prostate adenocarcinoma. ( 25686614 )
2015
39
Paraneoplastic cerebellar degeneration in a patient with ovarian cancer. ( 26166348 )
2015
40
Rapid Eye Movement-Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy. ( 26414894 )
2015
41
Anti-yo antibody uptake and interaction with its intracellular target antigen causes purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. ( 25885452 )
2015
42
Diagnosis of Dual Malignancy by 18F-FDG-PET/CT in the setting of Paraneoplastic Cerebellar Degeneration. ( 26271804 )
2015
43
Surgical diagnosis of stage I fallopian tube cancer in anti-Yo antibody paraneoplastic cerebellar degeneration. ( 24960213 )
2014
44
Antibodies to Delta/notch-like epidermal growth factor-related receptor in patients with anti-Tr, paraneoplastic cerebellar degeneration, and Hodgkin lymphoma. ( 24935874 )
2014
45
Diffuse large B-cell lymphoma of stomach presenting with paraneoplastic cerebellar degeneration syndrome. ( 24717988 )
2014
46
Ovarian cancer revealed by paraneoplastic cerebellar degeneration: a case report. ( 25360186 )
2014
47
Carbonic anhydrase-related protein VIII antibodies and paraneoplastic cerebellar degeneration. ( 24446689 )
2014
48
Hodgkin lymphoma-associated paraneoplastic cerebellar degeneration on FDG-PET/CT. ( 24460525 )
2014
49
Paraneoplastic cerebellar degeneration as the first evidence of malignancy: a case report. ( 24689522 )
2014
50
Paraneoplastic cerebellar degeneration associated with noncutaneous Merkel cell carcinoma. ( 25340069 )
2014

Variations for Paraneoplastic Cerebellar Degeneration

Expression for Paraneoplastic Cerebellar Degeneration

Search GEO for disease gene expression data for Paraneoplastic Cerebellar Degeneration.

Pathways for Paraneoplastic Cerebellar Degeneration

GO Terms for Paraneoplastic Cerebellar Degeneration

Cellular components related to Paraneoplastic Cerebellar Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone acetyltransferase complex GO:0000123 8.96 MORF4L1 MORF4L2
2 NuA4 histone acetyltransferase complex GO:0035267 8.62 MORF4L1 MORF4L2

Biological processes related to Paraneoplastic Cerebellar Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adult walking behavior GO:0007628 9.16 CACNA1A ZIC1
2 regulation of cell motility GO:2000145 8.96 ERBB2 PKN1
3 histone H2A acetylation GO:0043968 8.62 MORF4L1 MORF4L2

Molecular functions related to Paraneoplastic Cerebellar Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 AU-rich element binding GO:0017091 8.62 ELAVL3 ELAVL4

Sources for Paraneoplastic Cerebellar Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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