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MCID: PRN032
MIFTS: 36

Paraneoplastic Cerebellar Degeneration

Categories: Cancer diseases, Immune diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Paraneoplastic Cerebellar Degeneration

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MalaCards integrated aliases for Paraneoplastic Cerebellar Degeneration:

Name: Paraneoplastic Cerebellar Degeneration 53 55 73

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Respiratory diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 73 C0393534
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Summaries for Paraneoplastic Cerebellar Degeneration

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NIH Rare Diseases : 53 Paraneoplastic syndromes are a group of rare disorders that include paraneoplastic cerebellar degeneration (PCD). Paraneoplastic syndromes are thought to result from an abnormal immune response to an underlying (and often undetected) malignant tumor. PCD is a rare, non-metastatic complication of cancer. PCD is typically thought to be caused by antibodies generated against tumor cells. Instead of just attacking the cancer cells, the cancer-fighting antibodies also attack normal cells in the cerebellum. PCD occurs most often in individuals with the following cancers: ovarian cancer, cancer of the uterus, breast cancer, small-cell lung cancer, and Hodgkin lymphoma. Symptoms of PCD may include dizziness, loss of coordination, blurred vision, nystagmus, ataxia, and speech difficulties.

MalaCards based summary : Paraneoplastic Cerebellar Degeneration is related to cerebellar degeneration and small cell cancer of the lung, and has symptoms including cerebellar ataxia An important gene associated with Paraneoplastic Cerebellar Degeneration is CDR2 (Cerebellar Degeneration Related Protein 2). The drugs Tacrolimus and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lung, uterus and cerebellum, and related phenotype is behavior/neurological.

Wikipedia : 76 Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic syndrome associated with a broad... more...

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Related Diseases for Paraneoplastic Cerebellar Degeneration

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Diseases related to Paraneoplastic Cerebellar Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 cerebellar degeneration 32.9 CACNA1A CDR1 CDR2
2 small cell cancer of the lung 30.1 ELAVL4 ENO2 GRP
3 subacute cerebellar degeneration 11.2
4 lymphoma 10.5
5 adenocarcinoma 10.5
6 ovarian cancer 10.4
7 breast cancer 10.4
8 ovarian cancer 1 10.4
9 lung cancer 10.3
10 lambert-eaton myasthenic syndrome 10.3
11 b-cell lymphomas 10.2
12 diffuse large b-cell lymphoma 10.2
13 lymphoma, hodgkin, classic 10.2
14 squamous cell carcinoma 10.2
15 fallopian tube adenocarcinoma 10.2
16 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2
17 encephalitis 10.2
18 limbic encephalitis 10.2
19 urinary bladder small cell neuroendocrine carcinoma 10.1 ENO2 GRP
20 lung meningioma 10.1 ENO2 GRP
21 myeloma, multiple 10.1
22 endometrial cancer 10.1
23 severe combined immunodeficiency 10.1
24 nephrotic syndrome 10.1
25 merkel cell carcinoma 10.1
26 combined t cell and b cell immunodeficiency 10.1
27 paraneoplastic neurologic disorders 10.0 ELAVL4 ZIC1
28 kidney rhabdoid cancer 10.0 ELAVL3 ELAVL4 ENO2
29 cone-rod dystrophy 2 10.0 CDR1 CDR2 LGALS4
30 duodenal gastrinoma 10.0 ENO2 GRP
31 respiratory system cancer 10.0 ENO2 ERBB2 GRP
32 bladder cancer 9.9
33 multiple sclerosis 9.9
34 melanoma, uveal 9.9
35 suppression of tumorigenicity 12 9.9
36 aceruloplasminemia 9.9
37 cholangiocarcinoma 9.9
38 bipolar disorder 9.9
39 follicular lymphoma 9.9
40 small cell carcinoma 9.9
41 secondary progressive multiple sclerosis 9.9
42 ovarian clear cell carcinoma 9.9
43 marantic endocarditis 9.9
44 dermatomyositis 9.9
45 endocarditis 9.9
46 melanoma 9.9
47 fallopian tube carcinoma 9.9
48 relapsing-remitting multiple sclerosis 9.9
49 transitional cell carcinoma 9.9
50 papillary carcinoma 9.9

Graphical network of the top 20 diseases related to Paraneoplastic Cerebellar Degeneration:



Diseases related to Paraneoplastic Cerebellar Degeneration
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Symptoms & Phenotypes for Paraneoplastic Cerebellar Degeneration

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UMLS symptoms related to Paraneoplastic Cerebellar Degeneration:


cerebellar ataxia

MGI Mouse Phenotypes related to Paraneoplastic Cerebellar Degeneration:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.32 AMPH CA8 CACNA1A ELAVL3 ELAVL4 ENO2
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Drugs & Therapeutics for Paraneoplastic Cerebellar Degeneration

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Drugs for Paraneoplastic Cerebellar Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Not Applicable 104987-11-3 445643 439492
2
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
3 Calcineurin Inhibitors Not Applicable
4 Immunologic Factors Not Applicable
5 Immunosuppressive Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Not Applicable Tacrolimus

Search NIH Clinical Center for Paraneoplastic Cerebellar Degeneration

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Genetic Tests for Paraneoplastic Cerebellar Degeneration

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Anatomical Context for Paraneoplastic Cerebellar Degeneration

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MalaCards organs/tissues related to Paraneoplastic Cerebellar Degeneration:

41
Lung, Uterus, Cerebellum, T Cells, B Cells, Ovary, Kidney
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Publications for Paraneoplastic Cerebellar Degeneration

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Articles related to Paraneoplastic Cerebellar Degeneration:

(show top 50) (show all 281)
# Title Authors Year
1
Anti-Yo associated paraneoplastic cerebellar degeneration presenting as an acute cerebellitis with posterior cranial fossa hypertension. ( 29378343 )
2018
2
Genetic alterations and tumor immune attack in Yo paraneoplastic cerebellar degeneration. ( 29299667 )
2018
3
Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome Associated with Neuroendocrine Carcinoma of the Oropharynx. ( 29093415 )
2018
4
Paraneoplastic cerebellar degeneration with bilateral facial palsy: a rare primary presentation of breast cancer. ( 29930189 )
2018
5
Anti-ZIC4 associated paraneoplastic cerebellar degeneration in a patient with both diffuse large B-cell lymphoma and incidental smoldering multiple myeloma. ( 29249374 )
2018
6
Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. ( 29679372 )
2018
7
Transcriptomic immune profiling of ovarian cancers in paraneoplastic cerebellar degeneration associated with anti-Yo antibodies. ( 29899393 )
2018
8
Paraneoplastic cerebellar degeneration associated with cerebellar hypermetabolism: Case report. ( 29901574 )
2018
9
Paraneoplastic cerebellar degeneration in a patient with anaplastic non-Hodgkin's lymphoma. ( 29909387 )
2018
10
Paraneoplastic Cerebellar Degeneration Associated With Ovarian Adenocarcinoma: A Case Report and Review of Literature. ( 30532364 )
2018
11
Paraneoplastic cerebellar degeneration associated with breast cancer: A case report and review of the literature. ( 30101014 )
2018
12
Paraneoplastic cerebellar degeneration as a manifestation of metastatic recurrent carcinoma breast: rare scenario. ( 30150330 )
2018
13
Transient Diffusion-weighted Imaging Hyperintensity of the Cerebellar Cortex in Paraneoplastic Cerebellar Degeneration. ( 30210124 )
2018
14
TRIM9 and TRIM67 Are New Targets in Paraneoplastic Cerebellar Degeneration. ( 30350014 )
2018
15
Pearls & Oy-sters: Windmill nystagmus in paraneoplastic cerebellar degeneration. ( 30397048 )
2018
16
Long-Standing evolution of paraneoplastic cerebellar degeneration in a diffuse large B-cell lymphoma. ( 30476652 )
2018
17
Paraneoplastic cerebellar degeneration in a patient with a primary fallopian tube adenocarcinoma. A case report and brief review. ( 28386581 )
2017
18
Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer. ( 28377827 )
2017
19
Anti-Yo positive paraneoplastic cerebellar degeneration in the setting of cholangiocarcinoma. ( 27816258 )
2017
20
Paraneoplastic Cerebellar Degeneration Associated with Pelvic Liposarcoma: A Rare Case Report. ( 28092914 )
2017
21
Adult Onset Sporadic Cerebellar Ataxia in Singapore: Diagnostic Outcomes of Paraneoplastic Antibody Testing and Early Clinical Features of Paraneoplastic Cerebellar Degeneration. ( 28417137 )
2017
22
Anti-Yo positive and late-onset paraneoplastic cerebellar degeneration associated with ovarian carcinoma: A case report. ( 28796031 )
2017
23
Paraneoplastic cerebellar degeneration secondary to ovarian carcinosarcoma: a cerebellar conundrum. ( 28790096 )
2017
24
Rehabilitation for a patient with anti-Yo antibody-positive paraneoplastic cerebellar degeneration caused by breast cancer: A case report and literature review. ( 29095299 )
2017
25
A Rare Clinical Entity in Bladder Cancer: Paraneoplastic Cerebellar Degeneration. ( 28506560 )
2017
26
Paraneoplastic cerebellar degeneration associated with anti-ITPR1 antibodies. ( 28203616 )
2017
27
Erratum to: Hodgkin's lymphoma associated with paraneoplastic cerebellar degeneration in children: a case report and review of the literature. ( 28447149 )
2017
28
An uncommon manifestation of paraneoplastic cerebellar degeneration in a patient with high grade urothelial, carcinoma with squamous differentiation: A case report and literature review. ( 27209351 )
2016
29
Paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenia in a patient with Merkel cell carcinoma and voltage-gated calcium channel antibodies. ( 28006860 )
2016
30
Paraneoplastic cerebellar degeneration as a marker of endometrial cancer recurrence. ( 27194676 )
2016
31
Hodgkin's lymphoma associated with paraneoplastic cerebellar degeneration in children: a case report and review of the literature. ( 27796550 )
2016
32
Autoimmune neurological syndromes associated limbic encephalitis and paraneoplastic cerebellar degeneration. ( 27592059 )
2016
33
Paraneoplastic cerebellar degeneration and endometrial cancer: a rare occurrence. ( 27020505 )
2016
34
Paraneoplastic cerebellar degeneration with anti-Yo antibodies - a review. ( 27606347 )
2016
35
A case of slowly progressive anti-Yo-associated paraneoplastic cerebellar degeneration successfully treated with antitumor and immunotherapy. ( 27356731 )
2016
36
Anti-Ri antibody-mediated paraneoplastic cerebellar degeneration: A rare, treatable yet poorly recognized entity. ( 27625249 )
2016
37
Restoring Balance: Paraneoplastic Cerebellar Degeneration. ( 27816447 )
2016
38
Diagnosis of Dual Malignancy by 18F-FDG PET/CT in the Setting of Paraneoplastic Cerebellar Degeneration. ( 26271804 )
2016
39
Paraneoplastic Cerebellar Degeneration-A Rare Presentation of Ovarian Malignancy. ( 27803545 )
2016
40
Standardized test for anti-Tr/DNER in patients with paraneoplastic cerebellar degeneration. ( 25745634 )
2015
41
Paraneoplastic cerebellar degeneration and dermatomyositis as first manifestations of underlying breast malignancy: a report of two cases and a brief review of the subject. ( 26366356 )
2015
42
Plasticity-related gene 5: A novel surface autoantigen in paraneoplastic cerebellar degeneration. ( 26445730 )
2015
43
Paraneoplastic cerebellar degeneration as an early sign of classical Hodgkin lymphoma. ( 26542148 )
2015
44
Anti-Hu Antibody Associated Paraneoplastic Cerebellar Degeneration in Head and Neck Cancer. ( 26694863 )
2015
45
Paraneoplastic cerebellar degeneration associated with small cell neuroendocrine mediastinal carcinoma. ( 26026691 )
2015
46
A Rare Case of Ovarian Cancer Presenting with Paraneoplastic Cerebellar Degeneration and Limbic Encephalitis. ( 26415811 )
2015
47
Paraneoplastic cerebellar degeneration with anti-CV2/CRMP5 antibodies and prostate adenocarcinoma. ( 25686614 )
2015
48
Paraneoplastic cerebellar degeneration in a patient with ovarian cancer. ( 26166348 )
2015
49
Rapid Eye Movement-Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy. ( 26414894 )
2015
50
Anti-yo antibody uptake and interaction with its intracellular target antigen causes purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. ( 25885452 )
2015
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Variations for Paraneoplastic Cerebellar Degeneration

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Expression for Paraneoplastic Cerebellar Degeneration

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Search GEO for disease gene expression data for Paraneoplastic Cerebellar Degeneration.
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Pathways for Paraneoplastic Cerebellar Degeneration

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GO Terms for Paraneoplastic Cerebellar Degeneration

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Cellular components related to Paraneoplastic Cerebellar Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone acetyltransferase complex GO:0000123 8.96 MORF4L1 MORF4L2
2 NuA4 histone acetyltransferase complex GO:0035267 8.62 MORF4L1 MORF4L2

Biological processes related to Paraneoplastic Cerebellar Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell motility GO:2000145 9.16 ERBB2 PKN1
2 chromatin silencing GO:0006342 8.96 MORF4L1 MORF4L2
3 histone H2A acetylation GO:0043968 8.62 MORF4L1 MORF4L2

Molecular functions related to Paraneoplastic Cerebellar Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 AU-rich element binding GO:0017091 8.62 ELAVL3 ELAVL4
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Sources for Paraneoplastic Cerebellar Degeneration

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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