MCID: PRN032
MIFTS: 28

Paraneoplastic Cerebellar Degeneration

Categories: Cancer diseases, Immune diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Paraneoplastic Cerebellar Degeneration

MalaCards integrated aliases for Paraneoplastic Cerebellar Degeneration:

Name: Paraneoplastic Cerebellar Degeneration 52 54 71

Classifications:



External Ids:

UMLS 71 C0393534

Summaries for Paraneoplastic Cerebellar Degeneration

NIH Rare Diseases : 52 Paraneoplastic syndromes are a group of rare disorders that include paraneoplastic cerebellar degeneration (PCD). Paraneoplastic syndromes are thought to result from an abnormal immune response to an underlying (and often undetected) malignant tumor . PCD is a rare, non-metastatic complication of cancer . PCD is typically thought to be caused by antibodies generated against tumor cells . Instead of just attacking the cancer cells, the cancer-fighting antibodies also attack normal cells in the cerebellum . PCD occurs most often in individuals with the following cancers: ovarian cancer, cancer of the uterus, breast cancer, small-cell lung cancer, and Hodgkin lymphoma. Symptoms of PCD may include dizziness, loss of coordination, blurred vision, nystagmus , ataxia , and speech difficulties.

MalaCards based summary : Paraneoplastic Cerebellar Degeneration is related to cerebellar degeneration and paraneoplastic neurologic disorders, and has symptoms including cerebellar ataxia An important gene associated with Paraneoplastic Cerebellar Degeneration is CDR2 (Cerebellar Degeneration Related Protein 2). The drugs Immunologic Factors and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and cerebellum.

Wikipedia : 74 Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic syndrome associated with a broad... more...

Related Diseases for Paraneoplastic Cerebellar Degeneration

Diseases related to Paraneoplastic Cerebellar Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 cerebellar degeneration 32.7 CDR2 CDR1
2 paraneoplastic neurologic disorders 11.8
3 subacute cerebellar degeneration 11.7
4 ataxia and polyneuropathy, adult-onset 10.9
5 aceruloplasminemia 10.7
6 ovarian cancer 10.7
7 pathologic nystagmus 10.6
8 adenocarcinoma 10.6
9 paraneoplastic syndromes 10.6
10 breast cancer 10.5
11 lambert-eaton myasthenic syndrome 10.5
12 small cell carcinoma 10.5
13 small cell cancer of the lung 10.5
14 ovary adenocarcinoma 10.4
15 tremor 10.4
16 lymphoma, hodgkin, classic 10.4
17 lymphoma 10.4
18 limbic encephalitis 10.4
19 dysphagia 10.4
20 encephalitis 10.3
21 fallopian tube adenocarcinoma 10.3
22 gastric adenocarcinoma 10.3
23 autoimmune disease 10.2
24 bladder cancer 10.2
25 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
26 diffuse large b-cell lymphoma 10.2
27 lung oat cell carcinoma 10.2
28 b-cell lymphoma 10.2
29 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2
30 lung cancer 10.2
31 endometrial cancer 10.2
32 squamous cell carcinoma 10.2
33 myoclonus 10.2
34 renal cell carcinoma, nonpapillary 10.1
35 myeloma, multiple 10.1
36 follicular lymphoma 10.1
37 ptosis 10.1
38 nephrotic syndrome 10.1
39 neuroendocrine carcinoma 10.1
40 fallopian tube carcinoma 10.1
41 sensory peripheral neuropathy 10.1
42 cerebellar disease 10.1
43 papillary carcinoma 10.1
44 serous cystadenocarcinoma 10.1
45 merkel cell carcinoma 10.1
46 severe combined immunodeficiency 10.1
47 combined t cell and b cell immunodeficiency 10.1
48 neuroblastoma 10.1
49 colorectal cancer 9.9
50 major affective disorder 1 9.9

Graphical network of the top 20 diseases related to Paraneoplastic Cerebellar Degeneration:



Diseases related to Paraneoplastic Cerebellar Degeneration

Symptoms & Phenotypes for Paraneoplastic Cerebellar Degeneration

UMLS symptoms related to Paraneoplastic Cerebellar Degeneration:


cerebellar ataxia

Drugs & Therapeutics for Paraneoplastic Cerebellar Degeneration

Drugs for Paraneoplastic Cerebellar Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2
2 Immunoglobulins Phase 2
3 Antibodies Phase 2
4 Rho(D) Immune Globulin Phase 2
5 Immunoglobulins, Intravenous Phase 2
6 gamma-Globulins Phase 2
7
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
8
Prednisone Approved, Vet_approved 53-03-2 5865
9 Immunosuppressive Agents
10 Calcineurin Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Onset Immunotherapy by Intravenous Immunoglobulin in Well-characterized Onconeural-antibody-positive Paraneoplastic Neurological Syndromes Completed NCT02343211 Phase 2 Immunoglobulin
2 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Tacrolimus

Search NIH Clinical Center for Paraneoplastic Cerebellar Degeneration

Genetic Tests for Paraneoplastic Cerebellar Degeneration

Anatomical Context for Paraneoplastic Cerebellar Degeneration

MalaCards organs/tissues related to Paraneoplastic Cerebellar Degeneration:

40
Lung, Breast, Cerebellum, T Cells, Uterus, B Cells, Brain

Publications for Paraneoplastic Cerebellar Degeneration

Articles related to Paraneoplastic Cerebellar Degeneration:

(show top 50) (show all 499)
# Title Authors PMID Year
1
Functional analysis of CD8+ T cell responses to the onconeural self protein cdr2 in patients with paraneoplastic cerebellar degeneration. 54 61
18053582 2008
2
Induction of cytotoxic T lymphocytes specific for paraneoplastic cerebellar degeneration-associated antigen in vivo by DNA immunization. 54 61
11771954 2001
3
Cytotoxic T cell activity against the peptide, AYRARALEL, from Yo protein of patients with the HLA A24 or B27 supertype and paraneoplastic cerebellar degeneration. 54 61
11489286 2001
4
Cdr2, a target antigen of naturally occuring human tumor immunity, is widely expressed in gynecological tumors. 54 61
10786675 2000
5
Cytotoxic T cells against a peptide of Yo protein in patients with paraneoplastic cerebellar degeneration and anti-Yo antibody. 54 61
10500270 1999
6
The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival. 54 61
10465786 1999
7
Cytotoxic T cells react with recombinant Yo protein from a patient with paraneoplastic cerebellar degeneration and anti-Yo antibody. 54 61
9879687 1998
8
Failure to detect cytotoxic T cell activity against recombinant Yo protein using autologous dendritic cells as the target in a patient with paraneoplastic cerebellar degeneration and anti-Yo antibody. 54 61
9527904 1998
9
Expression of messenger RNA encoding a paraneoplastic cerebellar degeneration-associated antigen in the rat hippocampus. 54 61
8545049 1995
10
Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody. 2. Passive transfer of murine mononuclear cells activated with recombinant Yo protein to paraneoplastic cerebellar degeneration lymphocytes in severe combined immunodeficiency mice. 54 61
7788964 1995
11
Combined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic Malignancy. 61
31970005 2020
12
Paraneoplastic Cerebellar Degeneration in Nasopharyngeal Carcinoma: a Unique Association. 61
31161534 2019
13
Non-small cell lung cancer associated with late-onset Lambert-Eaton myasthenic syndrome and paraneoplastic cerebellar degeneration. 61
31735997 2019
14
Stroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature. 61
31463826 2019
15
Cerebellar Hypermetabolism in a Case of Paraneoplastic Cerebellar Syndrome With the Primary Lymphoepithelial Carcinoma in Tonsil. 61
31162262 2019
16
Rare case of paraneoplastic cerebellar degeneration secondary to high-grade serous carcinoma of tubo-ovarian origin. 61
31466977 2019
17
CDR2L Is the Major Yo Antibody Target in Paraneoplastic Cerebellar Degeneration. 61
31148214 2019
18
GRP78 antibodies damage the blood-brain barrier and relate to cerebellar degeneration in Lambert-Eaton myasthenic syndrome. 61
31236596 2019
19
Cerebellar Ataxia With Extreme Photophobia Associated With Anti-SOX1 Antibodies. 61
31244974 2019
20
[Paraneoplastic cerebellar degeneration and primary fallopian cancer]. 61
31239210 2019
21
Revisiting the Clinical Phenomenology of "Cerebellar Tremor": Beyond the Intention Tremor. 61
30565088 2019
22
A quaint masquerader of breast cancer: Paraneoplastic cerebellar degeneration. 61
31347580 2019
23
TRIM9 and TRIM67 Are New Targets in Paraneoplastic Cerebellar Degeneration. 61
30350014 2019
24
IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration. 61
30944244 2019
25
'A Story Unheard': anti-Ta associated paraneoplastic cerebellar degeneration in a female. 61
31044049 2019
26
Transient Diffusion-weighted Imaging Hyperintensity of the Cerebellar Cortex in Paraneoplastic Cerebellar Degeneration. 61
30210124 2019
27
Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. 61
29679372 2019
28
[Paraneoplastic Cerebellar Degeneration with Lambert-Eaton Myasthenic Syndrome: A Report of an Effectively Treated Case and Systematic Review of Japanese Cases]. 61
30718446 2019
29
The utility of anti-SOX2 antibodies for cancer prediction in patients with paraneoplastic neurological disorders. 61
30445363 2019
30
Long-Standing evolution of paraneoplastic cerebellar degeneration in a diffuse large B-cell lymphoma. 61
30476652 2019
31
Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma. 61
31333854 2019
32
Variant Guillain-Barré syndrome in a patient with Hodgkin lymphoma: AMSAN. 61
30872931 2018
33
Anti-Yo antibody-mediated paraneoplastic cerebellar degeneration associated with cognitive affective syndrome in a patient with breast cancer: a case report and literature review. 61
30607127 2018
34
Pearls & Oy-sters: Windmill nystagmus in paraneoplastic cerebellar degeneration. 61
30397048 2018
35
[A Case of Rectal Colon Cancer with Paraneoplastic Cerebellar Degeneration]. 61
30382061 2018
36
Paraneoplastic Cerebellar Degeneration Associated With Ovarian Adenocarcinoma: A Case Report and Review of Literature. 61
30532364 2018
37
Time Is Cerebellum. 61
29460203 2018
38
Paraneoplastic cerebellar degeneration associated with breast cancer: A case report and review of the literature. 61
30101014 2018
39
Paraneoplastic cerebellar degeneration as a manifestation of metastatic recurrent carcinoma breast: rare scenario. 61
30150330 2018
40
Transcriptomic immune profiling of ovarian cancers in paraneoplastic cerebellar degeneration associated with anti-Yo antibodies. 61
29899393 2018
41
Paraneoplastic cerebellar degeneration with bilateral facial palsy: a rare primary presentation of breast cancer. 61
29930189 2018
42
Paraneoplastic cerebellar degeneration in a patient with anaplastic non-Hodgkin's lymphoma. 61
29909387 2018
43
[Paraneoplastic Syndromes in Ophthalmology (French version of the article)]. 61
29891101 2018
44
Paraneoplastic cerebellar degeneration associated with cerebellar hypermetabolism: Case report. 61
29901574 2018
45
Paraneoplastic syndrome associate with solitary fibrous tumor of pleura. 61
29697083 2018
46
Paraneoplastic syndromes in ophthalmology. 61
29784239 2018
47
Expression of the onconeural protein CDR1 in cerebellum and ovarian cancer. 61
29844866 2018
48
[Paraneoplastic cerebellar degeneration (PCD) - an interdisciplinary challenge in neurology, oncology and palliative care]. 61
29411193 2018
49
[Cerebellar Ataxia and Autoantibodies]. 61
29632285 2018
50
[P/Q-type Calcium Channel Antibodies in Lambert-Eaton Myasthenic Syndrome]. 61
29632282 2018

Variations for Paraneoplastic Cerebellar Degeneration

Expression for Paraneoplastic Cerebellar Degeneration

Search GEO for disease gene expression data for Paraneoplastic Cerebellar Degeneration.

Pathways for Paraneoplastic Cerebellar Degeneration

GO Terms for Paraneoplastic Cerebellar Degeneration

Sources for Paraneoplastic Cerebellar Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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