MCID: PRN033
MIFTS: 22

Paraneoplastic Neurologic Disorders

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Paraneoplastic Neurologic Disorders

MalaCards integrated aliases for Paraneoplastic Neurologic Disorders:

Name: Paraneoplastic Neurologic Disorders 53
Pnd 53

Classifications:



Summaries for Paraneoplastic Neurologic Disorders

NIH Rare Diseases : 53 Paraneoplastic neurologic disorders are a group of rare degenerative conditions that are triggered by a person's immune system response to a cancerous tumor. Researchers believe these disorders occur when cancer-fighting antibodies or white blood cells known as T cells mistakenly attack normal cells in the nervous system. Paraneoplastic neurologic disorders typically develop after mid-adulthood and are most common in people with lung, ovarian, lymphatic, or breast cancer. Symptoms generally develop over a period of days to weeks and usually occur prior to tumor detection. These symptoms may include difficulty in walking and/or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo. Paraneoplastic neurologic disorders include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis (inflammation of the brain and spinal cord), myasthenia gravis, cerebellar degeneration, limbic and/or brainstem encephalitis, neuromyotonia, and opsoclonus (involving eye movement) and sensory neuropathy. Treatment involves treatment of the underlying tumor, immunotherapy, and supportive therapy.

MalaCards based summary : Paraneoplastic Neurologic Disorders, also known as pnd, is related to stiff-person syndrome and human immunodeficiency virus type 1. An important gene associated with Paraneoplastic Neurologic Disorders is AP3B2 (Adaptor Related Protein Complex 3 Subunit Beta 2). The drugs Tacrolimus and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and t cells, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Paraneoplastic Neurologic Disorders

Diseases related to Paraneoplastic Neurologic Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 stiff-person syndrome 10.9
2 human immunodeficiency virus type 1 10.0
3 small cell cancer of the lung 9.8
4 lung cancer 9.8
5 neuronitis 9.8
6 breast cancer 9.7
7 encephalitis 9.7
8 limbic encephalitis 9.7
9 isolated dandy-walker malformation without hydrocephalus 9.3 ZIC1 ZIC4
10 isolated dandy-walker malformation with hydrocephalus 9.2 ZIC1 ZIC4
11 paraneoplastic cerebellar degeneration 9.2 ELAVL4 ZIC1
12 holoprosencephaly 8.9 ZIC1 ZIC4

Graphical network of the top 20 diseases related to Paraneoplastic Neurologic Disorders:



Diseases related to Paraneoplastic Neurologic Disorders

Symptoms & Phenotypes for Paraneoplastic Neurologic Disorders

MGI Mouse Phenotypes related to Paraneoplastic Neurologic Disorders:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.26 AP3B2 ELAVL4 ZIC1 ZIC4
2 nervous system MP:0003631 8.92 AP3B2 ELAVL4 ZIC1 ZIC4

Drugs & Therapeutics for Paraneoplastic Neurologic Disorders

Drugs for Paraneoplastic Neurologic Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Not Applicable 104987-11-3 445643 439492
2
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
3 Immunosuppressive Agents Not Applicable
4 Calcineurin Inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Not Applicable Tacrolimus

Search NIH Clinical Center for Paraneoplastic Neurologic Disorders

Genetic Tests for Paraneoplastic Neurologic Disorders

Anatomical Context for Paraneoplastic Neurologic Disorders

MalaCards organs/tissues related to Paraneoplastic Neurologic Disorders:

41
Lung, Brain, T Cells, Spinal Cord, Eye, Testis

Publications for Paraneoplastic Neurologic Disorders

Articles related to Paraneoplastic Neurologic Disorders:

(show all 20)
# Title Authors Year
1
Paraneoplastic neurologic disorders in small cell lung carcinoma: A prospective study. ( 26109714 )
2015
2
Gross cerebellar paraneoplastic neurological disorder in a patient with an occult breast cancer. ( 23595173 )
2013
3
Diagnosis and management of paraneoplastic neurologic disorders. ( 23900965 )
2013
4
Paraneoplastic Neurologic Disorders: A Brief Overview. ( 23264806 )
2012
5
Paraneoplastic neurologic disorders in children. ( 21161703 )
2011
6
Update on paraneoplastic neurologic disorders. ( 20479279 )
2010
7
Treatment of paraneoplastic neurologic disorders. ( 20842583 )
2010
8
Positron emission tomography-computed tomography in paraneoplastic neurologic disorders: systematic analysis and review. ( 20065123 )
2010
9
Update on paraneoplastic neurologic disorders. ( 21572897 )
2010
10
Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disorders. ( 17113466 )
2006
11
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. ( 15007130 )
2004
12
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. ( 15477575 )
2004
13
Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity. ( 14732616 )
2004
14
Spectrum of paraneoplastic neurologic disorders in women with breast and gynecologic cancer. ( 12792307 )
2003
15
The importance of defining the paraneoplastic neurologic disorders. ( 10362830 )
1999
16
Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. ( 10050892 )
1999
17
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. ( 9344654 )
1997
18
Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain. ( 8643438 )
1996
19
Immune modulation of paraneoplastic neurologic disorders. ( 7788966 )
1995
20
Clinical enigmas of paraneoplastic neurologic disorders. ( 7788978 )
1995

Variations for Paraneoplastic Neurologic Disorders

Expression for Paraneoplastic Neurologic Disorders

Search GEO for disease gene expression data for Paraneoplastic Neurologic Disorders.

Pathways for Paraneoplastic Neurologic Disorders

GO Terms for Paraneoplastic Neurologic Disorders

Sources for Paraneoplastic Neurologic Disorders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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