PND
MCID: PRN033
MIFTS: 26

Paraneoplastic Neurologic Disorders (PND)

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Paraneoplastic Neurologic Disorders

MalaCards integrated aliases for Paraneoplastic Neurologic Disorders:

Name: Paraneoplastic Neurologic Disorders 53
Pnd 53

Classifications:



Summaries for Paraneoplastic Neurologic Disorders

NIH Rare Diseases : 53 Paraneoplastic neurologic disorders are a group of rare degenerative conditions that are triggered by a person's immune system response to a cancerous tumor. Researchers believe these disorders occur when cancer-fighting antibodies or white blood cells known as T cells mistakenly attack normal cells in the nervous system. Paraneoplastic neurologic disorders typically develop after mid-adulthood and are most common in people with lung, ovarian, lymphatic, or breast cancer. Symptoms generally develop over a period of days to weeks and usually occur prior to tumor detection. These symptoms may include difficulty in walking and/or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo. Paraneoplastic neurologic disorders include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis (inflammation of the brain and spinal cord), myasthenia gravis, cerebellar degeneration, limbic and/or brainstem encephalitis, neuromyotonia, and opsoclonus (involving eye movement) and sensory neuropathy. Treatment involves treatment of the underlying tumor, immunotherapy, and supportive therapy.

MalaCards based summary : Paraneoplastic Neurologic Disorders, also known as pnd, is related to stiff-person syndrome and depression. An important gene associated with Paraneoplastic Neurologic Disorders is AP3B2 (Adaptor Related Protein Complex 3 Subunit Beta 2). The drugs Tacrolimus and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and eye, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Paraneoplastic Neurologic Disorders

Diseases related to Paraneoplastic Neurologic Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 stiff-person syndrome 11.0
2 depression 10.3
3 melanoma 10.1
4 anxiety 10.0
5 human immunodeficiency virus type 1 10.0
6 inflammatory bowel disease 10.0
7 hemoglobin e disease 10.0
8 panic disorder 10.0
9 irritable bowel syndrome 10.0
10 hemophilia 10.0
11 small cell cancer of the lung 10.0
12 lung cancer 10.0
13 breast cancer 9.8
14 encephalitis 9.8
15 limbic encephalitis 9.8
16 isolated dandy-walker malformation without hydrocephalus 9.8 ZIC1 ZIC4
17 isolated dandy-walker malformation with hydrocephalus 9.8 ZIC1 ZIC4
18 paraneoplastic cerebellar degeneration 9.8 ELAVL4 ZIC1
19 holoprosencephaly 9.6 ZIC1 ZIC4

Graphical network of the top 20 diseases related to Paraneoplastic Neurologic Disorders:



Diseases related to Paraneoplastic Neurologic Disorders

Symptoms & Phenotypes for Paraneoplastic Neurologic Disorders

MGI Mouse Phenotypes related to Paraneoplastic Neurologic Disorders:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.26 AP3B2 ELAVL4 ZIC1 ZIC4
2 nervous system MP:0003631 8.92 AP3B2 ELAVL4 ZIC1 ZIC4

Drugs & Therapeutics for Paraneoplastic Neurologic Disorders

Drugs for Paraneoplastic Neurologic Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Not Applicable 104987-11-3 445643 439492
2
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
3 Calcineurin Inhibitors Not Applicable
4 Immunologic Factors Not Applicable
5 Immunosuppressive Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Not Applicable Tacrolimus

Search NIH Clinical Center for Paraneoplastic Neurologic Disorders

Genetic Tests for Paraneoplastic Neurologic Disorders

Anatomical Context for Paraneoplastic Neurologic Disorders

MalaCards organs/tissues related to Paraneoplastic Neurologic Disorders:

41
Lung, Brain, Eye, Spinal Cord, T Cells, Liver, Testes

Publications for Paraneoplastic Neurologic Disorders

Articles related to Paraneoplastic Neurologic Disorders:

(show top 50) (show all 59)
# Title Authors Year
1
Neighborhood Effects on PND Symptom Severity for Women Enrolled in a Home Visiting Program. ( 29063413 )
2018
2
Application of the BACs-on-Beads™ assay for rapid prenatal detection application of BoBs™ for PND of aneuploidies and microdeletions. ( 29247566 )
2018
3
PBDE-47 and PBDE mixture (DE-71) toxicities and liver transcriptomic changes at PND 22 after in utero/postnatal exposure in the rat. ( 30206662 )
2018
4
Development and Psychometric Evaluation of a Questionnaire to Measure Attitudes Toward Perinatal Depression and Acceptability of Screening: The PND Attitudes and Screening Acceptability Questionnaire (PASAQ). ( 30265131 )
2018
5
Offering a choice between NIPT and invasive PND in prenatal genetic counseling: the impact of clinician characteristics on patients' test uptake. ( 30297905 )
2018
6
Brain Protection Beyond the OR: Consensus Statement on Perioperative Neurocognitive Disorders (PND). ( 30433915 )
2018
7
The association of Emergency Department presentations in pregnancy with hospital admissions for postnatal depression (PND): a cohort study based on linked population data. ( 28335736 )
2017
8
Balancing conceptions of disability in PND practices: Who, when and how? Response to Aviad Raz commentary: "Uncertain prophecies: How practitioners negotiate the prognostic ambivalence of 'disability' in prenatal diagnosis consultations.". ( 26683118 )
2016
9
Paraneoplastic neurologic disorders in small cell lung carcinoma: A prospective study. ( 26109714 )
2015
10
Relationship between Post Nasal Drip (PND) and Inflammatory Bowel Disease (IBD): A New Concept on Gastrointestinal Disease Management in Persian Medicine. ( 26171372 )
2014
11
Colostomy in an ischiopagus, 3(rd) PND conjoined twins with cross-circulation: Anaesthetic management. ( 25024487 )
2014
12
Diagnosis and management of paraneoplastic neurologic disorders. ( 23900965 )
2013
13
Paraneoplastic Neurologic Disorders: A Brief Overview. ( 23264806 )
2012
14
SUICIDALITY in the perinatal period: comparison of two self-report instruments. Results from PND-ReScU. ( 22215284 )
2012
15
Paraneoplastic neurologic disorders in children. ( 21161703 )
2011
16
Specialised care for PND. ( 21877526 )
2011
17
Update on paraneoplastic neurologic disorders. ( 20479279 )
2010
18
Treatment of paraneoplastic neurologic disorders. ( 20842583 )
2010
19
Positron emission tomography-computed tomography in paraneoplastic neurologic disorders: systematic analysis and review. ( 20065123 )
2010
20
Update on paraneoplastic neurologic disorders. ( 21572897 )
2010
21
Panic disorder as a risk factor for post-partum depression: Results from the Perinatal Depression-Research & Screening Unit (PND-ReScU) study. ( 19651446 )
2010
22
Ontogeny of the HPA axis of the CD1 mouse following 24 h maternal deprivation at pnd 3. ( 19897026 )
2010
23
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. ( 20234191 )
2010
24
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. ( 20234193 )
2010
25
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. ( 20364110 )
2010
26
Beyond "postpartum depressions": specific anxiety diagnoses during pregnancy predict different outcomes: results from PND-ReScU. ( 20554326 )
2010
27
NMR evidence of charge-dependent interaction between various PND V3 and CCR5 N-terminal peptides. ( 19117029 )
2009
28
A pilot scale study of a sequencing batch reactor treating municipal wastewater operated via the UP-PND process. ( 18701797 )
2008
29
Axis I psychopathology and functional impairment at the third month of pregnancy: Results from the Perinatal Depression-Research and Screening Unit (PND-ReScU) study. ( 19192445 )
2008
30
Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disorders. ( 17113466 )
2006
31
Experiencing a dilemma--accounts of working with PND. ( 16095254 )
2005
32
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. ( 15007130 )
2004
33
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. ( 15477575 )
2004
34
Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity. ( 14732616 )
2004
35
Spectrum of paraneoplastic neurologic disorders in women with breast and gynecologic cancer. ( 12792307 )
2003
36
Developmental lead exposure alters the stimulatory properties of cocaine at PND 30 and PND 90 in the rat. ( 10989272 )
2000
37
The importance of defining the paraneoplastic neurologic disorders. ( 10362830 )
1999
38
Determination of neutron spectra in a MOX plant for the qualification of the BD-PND bubble detector. ( 12877343 )
1999
39
Combining the hok/sok, parDE, and pnd postsegregational killer loci to enhance plasmid stability. ( 9143123 )
1997
40
NMR study of the peptide present in the principal neutralizing determinant (PND) of HIV-1 envelope glycoprotein gp120. ( 9178085 )
1997
41
Investigations using photo affinity labeled analogues confirm the binding between sCD4 and the PND of HIV-1, MN. ( 9425315 )
1997
42
Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain. ( 8643438 )
1996
43
Nucleotide sequence and characterization of the trbABC region of the IncI1 Plasmid R64: existence of the pnd gene for plasmid maintenance within the transfer region. ( 8626273 )
1996
44
Immune modulation of paraneoplastic neurologic disorders. ( 7788966 )
1995
45
Clinical enigmas of paraneoplastic neurologic disorders. ( 7788978 )
1995
46
Phitsanulok population: the highest incidence of hemoglobin E in the northern provinces of Thailand and PND counseling. ( 8629121 )
1995
47
Broadly neutralizing, MN-like PND-directed antibodies in Rwandan children with long-term HIV1 infection. ( 7481092 )
1995
48
Relative reactivity of the V3 loop PND of HIV-1 subtypes A, B, C, D, and F with sera from selected Ugandan localities. ( 7544970 )
1995
49
Mechanism of post-segregational killing by hok-homologue pnd of plasmid R483: two translational control elements in the pnd mRNA. ( 7783193 )
1995
50
The utility of the PND statistic: a reply to Allison and Gorman. ( 7993333 )
1994

Variations for Paraneoplastic Neurologic Disorders

Expression for Paraneoplastic Neurologic Disorders

Search GEO for disease gene expression data for Paraneoplastic Neurologic Disorders.

Pathways for Paraneoplastic Neurologic Disorders

GO Terms for Paraneoplastic Neurologic Disorders

Molecular functions related to Paraneoplastic Neurologic Disorders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.62 ZIC1 ZIC4

Sources for Paraneoplastic Neurologic Disorders

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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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