MCID: PRN018
MIFTS: 22

Paraneoplastic Polyneuropathy

Categories: Neuronal diseases

Aliases & Classifications for Paraneoplastic Polyneuropathy

MalaCards integrated aliases for Paraneoplastic Polyneuropathy:

Name: Paraneoplastic Polyneuropathy 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:8681
ICD9CM 34 357.3
MeSH 44 D020364
NCIt 50 C3981
SNOMED-CT 67 77659000
UMLS 70 C0270932

Summaries for Paraneoplastic Polyneuropathy

MalaCards based summary : Paraneoplastic Polyneuropathy is related to polyneuropathy and small cell cancer of the lung. An important gene associated with Paraneoplastic Polyneuropathy is NOVA2 (NOVA Alternative Splicing Regulator 2). Affiliated tissues include thymus and prostate.

Related Diseases for Paraneoplastic Polyneuropathy

Diseases related to Paraneoplastic Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 polyneuropathy 10.4
2 small cell cancer of the lung 10.1
3 small cell carcinoma 10.0
4 guillain-barre syndrome 10.0
5 carcinoid syndrome 10.0
6 ovarian cancer 9.8
7 lung cancer 9.8
8 osteogenic sarcoma 9.8
9 thymoma, familial 9.8
10 lambert-eaton myasthenic syndrome 9.8
11 mantle cell lymphoma 9.8
12 respiratory failure 9.8
13 neuritis 9.8
14 thymoma 9.8
15 thymus cancer 9.8
16 plexopathy 9.8
17 peripheral nervous system disease 9.8
18 axonal neuropathy 9.8
19 neuropathy 9.8
20 cerebellar degeneration 9.8
21 paraneoplastic cerebellar degeneration 9.8
22 miller fisher syndrome 9.7 MAG AMPH
23 autoimmune disease of peripheral nervous system 9.6 MAG AMPH
24 neuromuscular disease 9.6 MAG AMPH
25 motor neuron disease 9.5 MAG AMPH

Comorbidity relations with Paraneoplastic Polyneuropathy via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia

Graphical network of the top 20 diseases related to Paraneoplastic Polyneuropathy:



Diseases related to Paraneoplastic Polyneuropathy

Symptoms & Phenotypes for Paraneoplastic Polyneuropathy

Drugs & Therapeutics for Paraneoplastic Polyneuropathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Painful Chemotherapy -Induced Peripheral Neuropathy With the MC-5A Pain Therapy Medical Device, a Randomized, Double-Blind, Sham-Controlled Clinical Trial Completed NCT01261780 Phase 2 Sham device

Search NIH Clinical Center for Paraneoplastic Polyneuropathy

Cochrane evidence based reviews: paraneoplastic polyneuropathy

Genetic Tests for Paraneoplastic Polyneuropathy

Anatomical Context for Paraneoplastic Polyneuropathy

MalaCards organs/tissues related to Paraneoplastic Polyneuropathy:

40
Thymus, Prostate

Publications for Paraneoplastic Polyneuropathy

Articles related to Paraneoplastic Polyneuropathy:

(show all 22)
# Title Authors PMID Year
1
Dorsal cauda equina nerve root enhancement on magnetic resonance imaging due to ANNA-1-associated paraneoplastic polyneuropathy. 61
32290766 2020
2
Radiotherapy and Small Cell Carcinoma With Paraneoplastic Polyneuropathy: A Case Report. 61
31234207 2019
3
Carcinoid Tumor-Associated Paraneoplastic Polyneuropathy that Mimics Guillain-Barre Syndrome. 61
28360817 2016
4
[Diagnosis of paraneoplastic polyneuropathy in patients with breast cancer and small cell lung cancer]. 61
24874327 2014
5
High resolution sonography in the evaluation of the peripheral nervous system in polyneuropathy--a review of the literature. 61
23701599 2013
6
Endometrial carcinoma presenting as vasculitic sensorimotor polyneuropathy. 61
22567523 2011
7
Small cell carcinoma with paraneoplastic polyneuropathy and tumor embolization: a case report and literature review. 61
19546521 2010
8
Peripheral neuropathy in a cat with renal lymphoma. 61
19464217 2009
9
[Paraneoplastic polyneuropathy associated to blastic mantle cell lymphoma]. 61
19226492 2009
10
[85-years-old patient with paraneoplastic polyneuropathy]. 61
17726875 2007
11
Metastatic pure small-cell carcinoma of prostate. 61
15545846 2004
12
[Paraneoplasic polyneuropathy with anti-amphiphysin antibodies]. 61
15146211 2004
13
Iatrogenic painful neuropathic complications of surgery in cancer. 61
11683658 2001
14
Paraneoplastic polyneuropathy preceding the diagnosis of Hodgkin's disease and non-small cell lung cancer in a patient with concomitant Borrelia burgdorferi infection. 61
11401090 2001
15
Chronic polyneuropathies in Vest-Agder, Norway. 61
11284994 2001
16
Paraneoplastic polyneuropathy and subsequent recovery following tumor removal in a dog. 61
10416774 1999
17
A Case of Occult Breast Cancer With Paraneoplastic Polyneuropathy. 61
11091596 1997
18
[Results of treatment with plasmapheresis in myasthenic crisis and severe polyneuropathy]. 61
1819792 1991
19
[Paraneoplastic polyneuropathies]. 61
2657825 1989
20
Clinical and neurophysiologic features in paraneoplastic polyneuropathy. 61
3368977 1988
21
Paraneoplastic polyneuropathy associated with a carcinoid tumor of the cecum. 61
7148510 1982
22
[Paraneoplastic polyneuropathy in thymus cancer]. 61
5811275 1969

Variations for Paraneoplastic Polyneuropathy

Expression for Paraneoplastic Polyneuropathy

Search GEO for disease gene expression data for Paraneoplastic Polyneuropathy.

Pathways for Paraneoplastic Polyneuropathy

GO Terms for Paraneoplastic Polyneuropathy

Biological processes related to Paraneoplastic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA splicing, via spliceosome GO:0000398 9.32 NOVA2 NOVA1
2 chemical synaptic transmission GO:0007268 9.26 NOVA1 AMPH
3 regulation of alternative mRNA splicing, via spliceosome GO:0000381 9.16 NOVA2 NOVA1
4 negative regulation of cold-induced thermogenesis GO:0120163 8.96 NOVA2 NOVA1
5 regulation of RNA metabolic process GO:0051252 8.62 NOVA2 NOVA1

Molecular functions related to Paraneoplastic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding GO:0003729 8.62 NOVA2 NOVA1

Sources for Paraneoplastic Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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