MCID: PRN039
MIFTS: 37

Paraneoplastic Syndromes

Categories: Cancer diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Paraneoplastic Syndromes

MalaCards integrated aliases for Paraneoplastic Syndromes:

Name: Paraneoplastic Syndromes 54 55 72

Classifications:



External Ids:

UMLS 72 C0030472

Summaries for Paraneoplastic Syndromes

NINDS : 54 Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumor known as a "neoplasm." Paraneoplastic syndromes are thought to happen when cancer-fighting antibodies or white blood cells (known as T cells) mistakenly attack normal cells in the nervous system. These disorders typically affect middle-aged to older people and are most common in individuals with lung, ovarian, lymphatic, or breast cancer. Neurologic symptoms generally develop over a period of days to weeks and usually occur prior to the tumor being discovered. These symptoms may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo or dizziness. Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, myasthenia gravis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.

MalaCards based summary : Paraneoplastic Syndromes is related to oncogenic osteomalacia and neutrophilia, hereditary, and has symptoms including paraneoplastic opsoclonus ataxia An important gene associated with Paraneoplastic Syndromes is FGF23 (Fibroblast Growth Factor 23), and among its related pathways/superpathways are Signaling by GPCR and G alpha (s) signalling events. The drugs Denosumab and Diphosphonates have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and bone.

Wikipedia : 75 A paraneoplastic syndrome is a syndrome (a set of signs and symptoms) that is the consequence of cancer... more...

Related Diseases for Paraneoplastic Syndromes

Diseases related to Paraneoplastic Syndromes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 611)
# Related Disease Score Top Affiliating Genes
1 oncogenic osteomalacia 29.9 PTHLH FGF23
2 neutrophilia, hereditary 29.8 PTHLH IL6
3 osteomalacia 29.7 FGF23 CALCA
4 iron deficiency anemia 29.4 IL6 FGF23
5 bone resorption disease 29.4 IL6 CALCA
6 small cell cancer of the lung 29.2 RCVRN CALCA
7 parathyroid adenoma 28.8 PTHLH CALCA
8 hyperparathyroidism 28.5 PTHLH FGF23 CALCA
9 primary hyperparathyroidism 28.3 PTHLH FGF23 CALCA
10 paraneoplastic cerebellar degeneration 11.7
11 poems syndrome 11.6
12 multicentric reticulohistiocytosis 11.5
13 adenoma 11.5
14 peritonitis 11.5
15 carcinoid syndrome 11.5
16 leiomyoma 11.5
17 autoimmune encephalitis 11.5
18 leiomyomatosis 11.2
19 adrenal adenoma 11.2
20 small cell carcinoma of the bladder 11.2
21 cerebellar degeneration 10.5
22 lung cancer 10.4
23 dermatomyositis 10.4
24 lambert-eaton myasthenic syndrome 10.4
25 renal cell carcinoma, nonpapillary 10.4
26 myoclonus 10.4
27 small cell carcinoma 10.3
28 ataxia and polyneuropathy, adult-onset 10.3
29 syndrome of inappropriate antidiuretic hormone 10.3
30 limbic encephalitis 10.3
31 vasculitis 10.3
32 myasthenia gravis 10.3
33 thymoma, familial 10.3
34 thymoma 10.3
35 encephalitis 10.3
36 hypoglycemia 10.3
37 adenocarcinoma 10.3
38 neuroblastoma 1 10.2
39 ovarian cancer 10.2
40 myopathy 10.2
41 neuropathy 10.2
42 acanthosis nigricans 10.2
43 exanthem 10.2
44 squamous cell carcinoma 10.2
45 polymyositis 10.2
46 hepatocellular carcinoma 10.2
47 aceruloplasminemia 10.2
48 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
49 sensory peripheral neuropathy 10.2
50 fasciitis 10.2

Graphical network of the top 20 diseases related to Paraneoplastic Syndromes:



Diseases related to Paraneoplastic Syndromes

Symptoms & Phenotypes for Paraneoplastic Syndromes

UMLS symptoms related to Paraneoplastic Syndromes:


paraneoplastic opsoclonus ataxia

Drugs & Therapeutics for Paraneoplastic Syndromes

Drugs for Paraneoplastic Syndromes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 2 615258-40-7
2 Diphosphonates Phase 2
3 Immunologic Factors Phase 1, Phase 2
4 Antibodies Phase 1, Phase 2
5 Immunoglobulins Phase 1, Phase 2
6 Antineoplastic Agents, Immunological Phase 1, Phase 2
7 Antibodies, Monoclonal Phase 1, Phase 2
8
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
9
Prednisone Approved, Vet_approved 53-03-2 5865
10
gamma-Aminobutyric acid Approved, Investigational 56-12-2 119
11
Glutamic acid Approved, Nutraceutical 56-86-0 33032
12
Aspartic acid Approved, Nutraceutical 56-84-8 5960
13 Immunosuppressive Agents
14 Calcineurin Inhibitors
15 N-Methylaspartate

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Zoledronate Versus Ibandronate Comparative Evaluation: A Randomized Phase III, Open-Label, Multicenter, Parallel Group Clinical Trial to Evaluate and Compare the Efficacy, Safety Profile and Tolerability of Oral Ibandronate Versus Intravenous Zoledronate in the Treatment of Breast Cancer Patients With Bone Metastases Unknown status NCT00326820 Phase 3 ibandronate sodium;zoledronic acid;Zolendronic Acid
2 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of Zoledronate (4 and 8 mg) Administered Intravenously as an Adjuvant to Anticancer Therapy to Patients With Any Cancer With Bone Metastases Other Than Breast Cancer, Multiple Myeloma or Prostate Cancer Completed NCT00003884 Phase 3 zoledronic acid
3 A Phase III Randomized, Multicenter Non-Inferiority Trial Evaluating the Efficacy of Oral Ibandronate Versus Intravenous Zoledronate in the Reduction of Skeletal-Related Events in Patients With Metastatic Breast Cancer Withdrawn NCT00301886 Phase 3 ibandronate;zoledronate
4 A Single-arm, Multicenter, Proof-of-concept Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium Despite Recent Treatment With IV Bisphosphonates Completed NCT00896454 Phase 2 denosumab
5 A Phase I-II, 24-Week, Multi-Center, Double-Blind, Randomized, Dose-Ranging Study To Evaluate The Safety And Efficacy Of A Humanized Monoclonal Antibody To PTHrP Versus Zoledronic Acid In Patients With Breast Cancer Metastatic To Bone Completed NCT00060138 Phase 1, Phase 2 zoledronic acid
6 Comparison of Skeletal and Mineral Metabolism Responses in Healthy African-Americans and Caucasians Using a Continuous Seven-Day Parathyroid Hormone (PTH) or Parathyroid Hormone-related Protein (PTHrP) Infusion Withdrawn NCT01333267 Phase 1 Parathyroid Hormone-related Protein (1-36);parathyroid hormone (1-34);PTH (1-34) and PTHrP (1-36)
7 Cost-Effective Use of Bisphosphonates in Metastatic Bone Disease - A Comparison of Bone Marker Directed Zoledronic Acid Therapy to a Standard Schedule Unknown status NCT00458796 zoledronic acid
8 Studies of Neurological Paraneoplastic Syndromes Completed NCT00587106
9 Killer T Cell Activity in the Paraneoplastic Neurologic Syndromes Completed NCT00327236
10 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Tacrolimus
11 Determining the Maximal Safe Dose of a Continuous Infusion of Parathyroid Hormone-related Protein(1-36): Effects on Bone Formation Completed NCT00580788 Early Phase 1 PTHrP (1-36)
12 Genomic Profile and Tumor Immune Attack in Paraneoplastic Neurological Syndromes (PNS) Active, not recruiting NCT03963700

Search NIH Clinical Center for Paraneoplastic Syndromes

Genetic Tests for Paraneoplastic Syndromes

Anatomical Context for Paraneoplastic Syndromes

MalaCards organs/tissues related to Paraneoplastic Syndromes:

41
Lung, Breast, Bone, T Cells, Prostate, Skin, Kidney

Publications for Paraneoplastic Syndromes

Articles related to Paraneoplastic Syndromes:

(show top 50) (show all 1476)
# Title Authors PMID Year
1
Recoverin as a cancer-retina antigen. 9 38
16444517 2007
2
Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes. 9 38
16083340 2005
3
Treatment of malignancy-associated hypercalcemia and cachexia with humanized anti-parathyroid hormone-related protein antibody. 9 38
14613038 2003
4
Primary adenosquamous carcinoma of the liver which produces granulocyte-colony-stimulating factor and parathyroid hormone related protein: association with leukocytosis and hypercalcemia. 9 38
11506305 2001
5
Paraneoplastic hypercalcemia in a patient with adenosquamous cancer of the colon. 9 38
11409809 2001
6
Regulation of granulocyte colony-stimulating factor and parathyroid hormone-related protein production in lung carcinoma cell line OKa-C-1. 9 38
11011119 2000
7
Serum interleukin-6 levels in metastatic renal cell carcinoma before treatment with interleukin-2 correlates with paraneoplastic syndromes but not patient survival. 9 38
9474133 1998
8
Role of interleukin-6 in the paraneoplastic inflammatory syndrome associated with renal-cell carcinoma. 9 38
9247285 1997
9
ANOVA, a putative astrocytic RNA-binding protein gene that maps to chromosome 19q13.3. 9 38
10735272 1997
10
Paraneoplastic manifestations of renal cell carcinoma. 9 38
8946620 1996
11
Herbimycin A, a tyrosine kinase inhibitor, impairs hypercalcemia associated with a human squamous cancer producing interleukin-6 in nude mice. 9 38
8797110 1996
12
Granulocyte-colony stimulating factor produced by pancreatic carcinoma. 9 38
8723556 1996
13
Mechanisms of paraneoplastic syndromes of colon-26: involvement of interleukin 6 in hypercalcemia. 9 38
8142602 1993
14
Interleukin-6 in renal cell carcinoma. 9 38
1433606 1992
15
Hematopoietic growth factors secreted by seven human pleural mesothelioma cell lines: interleukin-6 production as a common feature. 9 38
1373705 1992
16
Pheochromocytoma with pyrexia and marked inflammatory signs: a paraneoplastic syndrome with possible relation to interleukin-6 production. 9 38
1890158 1991
17
Chinese hamster ovarian cells transfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. 9 38
2019273 1991
18
Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes. 9 38
2212010 1990
19
A case series of PD-1 inhibitor-associated paraneoplastic neurologic syndromes. 38
31195181 2019
20
Clinical, Imaging, and Pathologic Features of Conditions with Combined Esophageal and Cutaneous Manifestations. 38
31419189 2019
21
Review of oncological emergencies in small animal patients. 38
30900396 2019
22
Unusual Imaging Findings Associated with Germ Cell Tumors. 38
31125295 2019
23
IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes. 38
30918174 2019
24
Cutaneous paraneoplastic syndromes. 38
30736994 2019
25
Paraneoplastic syndromes: Definitions, classification, pathophysiology and principles of treatment. 38
30876820 2019
26
Synchronous Occurrence of Bazex Syndrome and Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome in a Patient with Lung Cancer. 38
31292397 2019
27
Tumor-induced osteomalacia - Current imaging modalities and a systematic approach for tumor localization. 38
31029010 2019
28
Clinical characteristics and long term follow-up of Lambert-Eaton myasthenia syndrome in patients with and without small cell lung cancer. 38
31072737 2019
29
Lung cancer with dermatomyositis as the initial diagnosis: A case report. 38
31289679 2019
30
Paraneoplastic syndromes and other systemic disorders associated with neuroendocrine neoplasms. 38
30910348 2019
31
A rare case of long-term paraesthesia diagnosed as a paraneoplastic syndrome by anti-SOX1 antibody determination. 38
31315840 2019
32
Paraneoplastic syndromes-"keys" to histopathological diagnoses and appropriate therapy. 38
30876819 2019
33
Improved Prognosis and Increased Tumor-Infiltrating Lymphocytes in Patients Who Have SCLC With Neurologic Paraneoplastic Syndromes. 38
31201935 2019
34
Paraneoplastic movement disorders: phenomenology, diagnosis, and treatment. 38
31200996 2019
35
[Paraneoplastic syndromes]. 38
31283129 2019
36
Paraneoplastic syndromes in cancers of unknown primary: An unknown field for oncologists. 38
31072598 2019
37
A blind spot in urology: Prostate cancer associated retinopathy. 38
31211081 2019
38
Lambert-Eaton myasthenic syndrome and merkel cell carcinoma. 38
31233589 2019
39
Mucocutaneous Paraneoplastic Syndrome Secondary to Classical Hodgkin's Lymphoma. 38
31061977 2019
40
Endocrine paraneoplastic syndromes in patients with neuroendocrine neoplasms. 38
30280284 2019
41
Increased Galectin-1 Expression in Thymic Epithelial Tumors. 38
30773448 2019
42
Thrombocytosis as a Rare Paraneoplastic Syndrome Occurring in Hepatocellular Carcinoma: A Case Report. 38
31019620 2019
43
Review of paraneoplastic syndromes in children. 38
30877339 2019
44
Diagnostic tools for immune causes of encephalitis. 38
30583056 2019
45
Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications. 38
31035457 2019
46
Paraneoplastic relapsing minimal change disease associated with type A thymoma in an elderly patient: A case report and literature review. 38
30846674 2019
47
Idiopathic Internal Jugular Vein and Subclavian Vein Thrombosis: A Rare Case Report. 38
31001459 2019
48
Dermatomyositis associated with adenocarcinoma of the lung: A case report. 38
30984709 2019
49
Triple negative breast cancer with ACTH-dependent Cushing's syndrome - case report. 38
31032808 2019
50
Paraneoplastic Lambert-Eaton syndrome in a patient with disseminated metastatic cancer. 38
30951047 2019

Variations for Paraneoplastic Syndromes

Expression for Paraneoplastic Syndromes

Search GEO for disease gene expression data for Paraneoplastic Syndromes.

Pathways for Paraneoplastic Syndromes

Pathways related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.35 RCVRN PTHLH IL6 FGF23 CALCA
2 11.49 PTHLH CALCA
3 11.18 PTHLH FGF23
4 10.76 IL6 CALCA
5 10.28 IL6 CALCA

GO Terms for Paraneoplastic Syndromes

Cellular components related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 PTHLH IL6 FGF23 CALCA
2 extracellular space GO:0005615 8.92 PTHLH IL6 FGF23 CALCA

Biological processes related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.26 PTHLH CALCA
2 monocyte chemotaxis GO:0002548 9.16 IL6 CALCA
3 cellular protein metabolic process GO:0044267 9.13 IL6 FGF23 CALCA
4 negative regulation of bone resorption GO:0045779 8.62 IL6 CALCA

Molecular functions related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.96 IL6 FGF23
2 hormone activity GO:0005179 8.62 PTHLH CALCA

Sources for Paraneoplastic Syndromes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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