MCID: PRN039
MIFTS: 38

Paraneoplastic Syndromes

Categories: Cancer diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Paraneoplastic Syndromes

MalaCards integrated aliases for Paraneoplastic Syndromes:

Name: Paraneoplastic Syndromes 53 54 71

Classifications:



External Ids:

UMLS 71 C0030472

Summaries for Paraneoplastic Syndromes

NINDS : 53 Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumor known as a "neoplasm." Paraneoplastic syndromes are thought to happen when cancer-fighting antibodies or white blood cells (known as T cells) mistakenly attack normal cells in the nervous system. These disorders typically affect middle-aged to older people and are most common in individuals with lung, ovarian, lymphatic, or breast cancer. Neurologic symptoms generally develop over a period of days to weeks and usually occur prior to the tumor being discovered. These symptoms may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo or dizziness. Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, myasthenia gravis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.

MalaCards based summary : Paraneoplastic Syndromes is related to poems syndrome and peritonitis, and has symptoms including paraneoplastic opsoclonus ataxia An important gene associated with Paraneoplastic Syndromes is RCVRN (Recoverin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Denosumab and Diphosphonates have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and t cells, and related phenotypes are integument and renal/urinary system

Wikipedia : 74 A paraneoplastic syndrome is a syndrome (a set of signs and symptoms) that is the consequence of cancer... more...

Related Diseases for Paraneoplastic Syndromes

Diseases related to Paraneoplastic Syndromes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 627)
# Related Disease Score Top Affiliating Genes
1 poems syndrome 32.2 IL6 CSF3
2 peritonitis 31.6 IL6 CSF3
3 osteomalacia 30.1 PTHLH FGF23
4 exanthem 30.0 IL6 CSF3
5 small cell cancer of the lung 29.9 RCVRN CSF3
6 thrombocytosis 29.9 IL6 CSF3
7 oncogenic osteomalacia 29.9 PTHLH FGF23
8 hypophosphatemia 29.8 PTHLH FGF23
9 iron deficiency anemia 29.6 IL6 FGF23
10 relapsing polychondritis 29.4 IL6 CSF3
11 hyperparathyroidism 29.4 PTHLH FGF23
12 castleman disease 29.3 IL6 CSF3
13 bone resorption disease 29.2 PTHLH IL6 FGF23
14 primary hyperparathyroidism 29.2 PTHLH FGF23
15 gastroenteritis 29.0 IL6 CSF3
16 metabolic acidosis 29.0 IL6 FGF23
17 myeloma, multiple 28.9 PTHLH IL6 CSF3
18 neutrophilia, hereditary 28.9 PTHLH IL6 CSF3
19 paraneoplastic cerebellar degeneration 11.7
20 multicentric reticulohistiocytosis 11.5
21 adenoma 11.5
22 carcinoid syndrome 11.5
23 leiomyoma 11.5
24 autoimmune encephalitis 11.5
25 small cell carcinoma of the bladder 11.5
26 leiomyomatosis 11.2
27 adrenal adenoma 11.2
28 cerebellar degeneration 10.5
29 lung cancer 10.4
30 dermatomyositis 10.4
31 lambert-eaton myasthenic syndrome 10.4
32 myoclonus 10.4
33 renal cell carcinoma, nonpapillary 10.4
34 small cell carcinoma 10.3
35 thymoma, familial 10.3
36 ataxia and polyneuropathy, adult-onset 10.3
37 thymoma 10.3
38 limbic encephalitis 10.3
39 myasthenia gravis 10.3
40 vasculitis 10.3
41 encephalitis 10.3
42 hypoglycemia 10.3
43 adenocarcinoma 10.3
44 neuroblastoma 10.3
45 myopathy 10.2
46 ovarian cancer 10.2
47 neuropathy 10.2
48 acanthosis nigricans 10.2
49 polymyositis 10.2
50 squamous cell carcinoma 10.2

Graphical network of the top 20 diseases related to Paraneoplastic Syndromes:



Diseases related to Paraneoplastic Syndromes

Symptoms & Phenotypes for Paraneoplastic Syndromes

UMLS symptoms related to Paraneoplastic Syndromes:


paraneoplastic opsoclonus ataxia

MGI Mouse Phenotypes related to Paraneoplastic Syndromes:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.26 CSF3 FGF23 IL6 PTHLH
2 renal/urinary system MP:0005367 8.92 CSF3 FGF23 IL6 PTHLH

Drugs & Therapeutics for Paraneoplastic Syndromes

Drugs for Paraneoplastic Syndromes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 2 615258-40-7
2 Diphosphonates Phase 2
3 Calcium, Dietary Phase 2
4
Calcium Nutraceutical Phase 2 7440-70-2 271
5
Prednisone Approved, Vet_approved 53-03-2 5865
6
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
7
gamma-Aminobutyric acid Approved, Investigational 56-12-2 119
8
Glutamic acid Approved, Nutraceutical 56-86-0 33032
9
Aspartic acid Approved, Nutraceutical 56-84-8 5960
10 Immunosuppressive Agents
11 Immunologic Factors
12 Calcineurin Inhibitors
13 Immunoglobulins
14 Antibodies
15 N-Methylaspartate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Single-arm, Multicenter, Proof-of-concept Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium Despite Recent Treatment With IV Bisphosphonates Completed NCT00896454 Phase 2 denosumab
2 A Phase I/II, Single Arm, Open Label, Multi-center Clinical Trial to Assess the Efficacy and Safety of JMT103 in Patients With Refractory Hypercalcemia of Malignancy Not yet recruiting NCT04198480 Phase 1, Phase 2 JMT103
3 Studies of Neurological Paraneoplastic Syndromes Completed NCT00587106
4 Killer T Cell Activity in the Paraneoplastic Neurologic Syndromes Completed NCT00327236
5 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Tacrolimus
6 Genomic Profile and Tumor Immune Attack in Paraneoplastic Neurological Syndromes (PNS) Active, not recruiting NCT03963700

Search NIH Clinical Center for Paraneoplastic Syndromes

Genetic Tests for Paraneoplastic Syndromes

Anatomical Context for Paraneoplastic Syndromes

MalaCards organs/tissues related to Paraneoplastic Syndromes:

40
Lung, Breast, T Cells, Prostate, Skin, Kidney, Liver

Publications for Paraneoplastic Syndromes

Articles related to Paraneoplastic Syndromes:

(show top 50) (show all 1534)
# Title Authors PMID Year
1
Recoverin as a cancer-retina antigen. 61 54
16444517 2007
2
Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes. 54 61
16083340 2005
3
Treatment of malignancy-associated hypercalcemia and cachexia with humanized anti-parathyroid hormone-related protein antibody. 54 61
14613038 2003
4
Primary adenosquamous carcinoma of the liver which produces granulocyte-colony-stimulating factor and parathyroid hormone related protein: association with leukocytosis and hypercalcemia. 61 54
11506305 2001
5
Paraneoplastic hypercalcemia in a patient with adenosquamous cancer of the colon. 54 61
11409809 2001
6
Regulation of granulocyte colony-stimulating factor and parathyroid hormone-related protein production in lung carcinoma cell line OKa-C-1. 61 54
11011119 2000
7
Serum interleukin-6 levels in metastatic renal cell carcinoma before treatment with interleukin-2 correlates with paraneoplastic syndromes but not patient survival. 61 54
9474133 1998
8
Role of interleukin-6 in the paraneoplastic inflammatory syndrome associated with renal-cell carcinoma. 54 61
9247285 1997
9
ANOVA, a putative astrocytic RNA-binding protein gene that maps to chromosome 19q13.3. 61 54
10735272 1997
10
Paraneoplastic manifestations of renal cell carcinoma. 61 54
8946620 1996
11
Herbimycin A, a tyrosine kinase inhibitor, impairs hypercalcemia associated with a human squamous cancer producing interleukin-6 in nude mice. 61 54
8797110 1996
12
Granulocyte-colony stimulating factor produced by pancreatic carcinoma. 54 61
8723556 1996
13
Mechanisms of paraneoplastic syndromes of colon-26: involvement of interleukin 6 in hypercalcemia. 61 54
8142602 1993
14
Interleukin-6 in renal cell carcinoma. 61 54
1433606 1992
15
Hematopoietic growth factors secreted by seven human pleural mesothelioma cell lines: interleukin-6 production as a common feature. 54 61
1373705 1992
16
Pheochromocytoma with pyrexia and marked inflammatory signs: a paraneoplastic syndrome with possible relation to interleukin-6 production. 54 61
1890158 1991
17
Chinese hamster ovarian cells transfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. 61 54
2019273 1991
18
Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes. 61 54
2212010 1990
19
Paraneoplastic Raynaud phenomenon associated with metastatic ovarian cancer: A case report and review of the literature. 61
32548231 2020
20
A tale of autoimmunity: thymoma, thymectomy, and systemic lupus erythematosus. 61
32277368 2020
21
A systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected cases. 61
31982129 2020
22
Renal hemangiopericytoma in 15 year old female-treated laparoscopically. 61
32195122 2020
23
Commentary: Dangerous liaisons-Paraneoplastic syndromes and thymoma. 61
32067787 2020
24
Commentary: Toward a better understanding of the natural history of surgically treated thymoma associated with paraneoplastic syndromes. 61
31992460 2020
25
Commentary: The enigma of surgery to cure thymic paraneoplastic syndromes. 61
31926722 2020
26
Myositis and myasthenia during nivolumab administration for advanced lung cancer: a case report and review of the literature. 61
32011360 2020
27
Doege-Potter Syndrome and Pierre-Marie-Bamberger Syndrome in a Patient With Pleural Solitary Fibrous Tumor: A Rare Case With Literature Review. 61
32494533 2020
28
Rhombencephalitis associated with isolated Zic4-antibodies in Paraneoplastic cerebellar degeneration: a case report. 61
32450842 2020
29
Anti-Hu-associated paraneoplastic syndromes triggered by immune-checkpoint inhibitor treatment. 61
32451614 2020
30
Retrospective Analysis of Mortality Cases in Advanced and Metastatic Solid Tumors With Concurrent Prerenal Azotemia. 61
32354956 2020
31
Cutaneous manifestations of internal malignancy. 61
32311823 2020
32
Seizures in patients with cancer. 61
31967671 2020
33
Recurrent Thymoma-Associated Paraneoplastic Encephalitis Resulting From Multiple Antibodies: A Case Report. 61
32373279 2020
34
Paraneoplastic manifestations of salivary gland tumours: A case report and review. 61
32061536 2020
35
Subacute sensory neuronopathy and cancer: the identification of paraneoplastic syndromes. 61
32245767 2020
36
A Case of a False-Positive Urine Pregnancy Test and Delayed Diagnosis of Obstructive Pyelonephritis. 61
32210220 2020
37
Cholestatic Hepatitis as a Possible Paraneoplastic Syndrome of Endometrial Carcinoma. 61
32337313 2020
38
Neurological complications of pediatric cancer. 61
31933235 2020
39
Antibody-Negative Paraneoplastic Limbic Encephalitis, Parkinsonism, Hypothermia, and Narcolepsy Associated with Endometrial Carcinoma. 61
32071946 2020
40
Anti-glutamic acid decarboxylase antibody paraneoplastic limbic encephalitis associated with Acute Myeloid Leukemia. 61
31786428 2020
41
Nivolumab efficacy in leptomeningeal metastasis of renal cell carcinoma: a case report. 61
32041500 2020
42
An ectopic Cushing's syndrome as a cause of severe refractory hypokalemia in the ICU. 61
32089125 2020
43
Contribution of Immune-Mediated Paraneoplastic Syndromes to Neurological Manifestations of Neuroendocrine Tumours: Retrospective Study. 61
32040952 2020
44
Long-term Survival of a Patient with Small Cell Lung Cancer Secreting ADH and ACTH Simultaneously, Following the Prolonged Use of Amrubicin. 61
31511478 2020
45
Malassezia Yeasts in Veterinary Dermatology: An Updated Overview. 61
32181160 2020
46
Refractory Renal Cell Cancer with Gastro-renal Fistula: A Rare Complication. 61
32051793 2020
47
Paraneoplastic leukemoid reaction in a patient with metastatic adenocarcinoma of the lung. 61
31998477 2020
48
The rashes that lead to cutaneous ulcers. 61
32197748 2020
49
Intrahepatic Cholangiocarcinoma Associated with High Procalcitonin, Hypercalcemia, Polycythemia and Leukocytosis. 61
32051799 2020
50
Current Techniques to Accurately Measure Anti-retinal Autoantibodies. 61
32318114 2020

Variations for Paraneoplastic Syndromes

Expression for Paraneoplastic Syndromes

Search GEO for disease gene expression data for Paraneoplastic Syndromes.

Pathways for Paraneoplastic Syndromes

Pathways related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 IL6 FGF23 CSF3
2 11.56 IL6 CSF3
3 11.48 PTHLH FGF23
4 11.43 IL6 CSF3
5
Show member pathways
11.37 IL6 CSF3
6 11.12 IL6 CSF3
7 10.96 IL6 CSF3
8 10.85 IL6 CSF3
9 10.64 IL6 CSF3
10 10.45 IL6 FGF23 CSF3
11 10.09 IL6 CSF3

GO Terms for Paraneoplastic Syndromes

Cellular components related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 PTHLH IL6 FGF23 CSF3

Biological processes related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.56 RCVRN PTHLH IL6 CSF3
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.32 IL6 CSF3
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.16 IL6 CSF3
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 8.96 IL6 CSF3
5 positive regulation of cell proliferation GO:0008284 8.8 PTHLH IL6 CSF3

Molecular functions related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 IL6 FGF23 CSF3

Sources for Paraneoplastic Syndromes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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