MCID: PRN009
MIFTS: 48

Paranoid Schizophrenia

Categories: Mental diseases

Aliases & Classifications for Paranoid Schizophrenia

MalaCards integrated aliases for Paranoid Schizophrenia:

Name: Paranoid Schizophrenia 12 56 15 74
Chronic Paranoid Schizophrenia 12 74
Paranoid Type Schizophrenia Subchronic State 12
Paranoid Type Schizophrenia 12
Paraphrenic Schizophrenia 12
Schizophrenia, Paranoid 45
Paraphrenia - Late 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1229
MeSH 45 D012563
NCIt 51 C35006
SNOMED-CT 69 31658008 64905009
ICD10 34 F20.0

Summaries for Paranoid Schizophrenia

Disease Ontology : 12 A schizophrenia characterized by delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.

MalaCards based summary : Paranoid Schizophrenia, also known as chronic paranoid schizophrenia, is related to traumatic brain injury and brain injury. An important gene associated with Paranoid Schizophrenia is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways are Calcium signaling pathway and Serotonergic synapse. The drugs Cycloserine and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Wikipedia : 77 Paranoid schizophrenia is the most common type of schizophrenia. Schizophrenia is defined as “a chronic... more...

Related Diseases for Paranoid Schizophrenia

Diseases related to Paranoid Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 30.2 BDNF COMT
2 brain injury 30.2 BDNF COMT
3 alexithymia 30.0 COMT SLC6A4
4 depression 30.0 BDNF HTR2A MAOA SLC6A4 TPH2
5 schizoaffective disorder 29.9 BDNF COMT HTR2A SLC6A4
6 alcohol abuse 29.8 BDNF HTR2A SLC6A4
7 personality disorder 29.6 BDNF COMT HTR2A MAOA SLC6A4
8 psychotic disorder 29.6 BDNF COMT HTR2A SLC6A4
9 autism spectrum disorder 29.5 BDNF HTR2A SLC6A4 TPH2
10 anxiety 29.5 BDNF COMT HTR2A MAOA SLC6A4 TPH2
11 post-traumatic stress disorder 29.4 BDNF COMT HTR2A MAOA SLC6A4
12 schizophrenia 29.2 BDNF CCKAR COMT DRD5 HTR2A MAOA
13 mood disorder 29.1 BDNF COMT HTR2A MAOA SLC6A4 TPH2
14 obsessive-compulsive disorder 29.1 BDNF COMT HTR2A MAOA SLC6A4 TPH2
15 alcohol dependence 29.1 BDNF COMT HTR2A MAOA SLC6A4 TPH2
16 major depressive disorder 28.8 BDNF COMT HTR2A MAOA NTRK2 SLC6A4
17 phobia, specific 10.3 COMT MAOA
18 early-onset schizophrenia 10.3 BDNF HTR2A
19 tardive dyskinesia 10.3 COMT HTR2A
20 nodular ganglioneuroblastoma 10.3 BDNF NTRK2
21 dystonia 1, torsion, autosomal dominant 10.2 COMT MAOA
22 vertebral artery occlusion 10.2 BDNF NTRK2
23 heroin dependence 10.2 BDNF MIAT
24 avoidant personality disorder 10.1 MAOA SLC6A4
25 hypogonadotropic hypogonadism 10.1
26 epilepsy 10.1
27 mutism 10.1
28 delusional disorder 10.1
29 social phobia 10.1 MAOA SLC6A4
30 kleptomania 10.1 MAOA SLC6A4
31 drug-induced hearing loss 10.1 BDNF NTRK2
32 psychosexual disorder 10.1 HTR2A SLC6A4
33 agoraphobia 10.1 MAOA SLC6A4
34 alcoholic psychosis 10.1 HTR2A SLC6A4
35 periodic limb movement disorder 10.0 HTR2A SLC6A4
36 gilles de la tourette syndrome 10.0 BDNF COMT DRD5
37 phobic disorder 10.0 COMT MAOA SLC6A4
38 cervical dystonia 10.0 BDNF DRD5
39 brunner syndrome 10.0 COMT MAOA SLC6A4
40 antisocial personality disorder 10.0 COMT MAOA SLC6A4
41 tic disorder 10.0 DRD5 HTR2A TPH2
42 eating disorder 10.0 BDNF COMT SLC6A4
43 atypical depressive disorder 10.0 HTR2A MAOA SLC6A4
44 marfan syndrome 10.0
45 autism 10.0
46 spinocerebellar ataxia 10 10.0
47 cervical cancer 10.0
48 peripartum cardiomyopathy 10.0
49 ulcerative colitis 10.0
50 colitis 10.0

Comorbidity relations with Paranoid Schizophrenia via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Alzheimer Disease
Deficiency Anemia Delusional Disorder
Hypertension, Essential Hypothyroidism
Major Depressive Disorder Paranoid Personality Disorder
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Schizophrenia Schizophreniform Disorder
Tardive Dyskinesia

Graphical network of the top 20 diseases related to Paranoid Schizophrenia:



Diseases related to Paranoid Schizophrenia

Symptoms & Phenotypes for Paranoid Schizophrenia

MGI Mouse Phenotypes related to Paranoid Schizophrenia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 BDNF CCKAR COMT DRD5 HTR2A MAOA
2 endocrine/exocrine gland MP:0005379 9.7 BDNF CCKAR COMT DRD5 HTR2A NTRK2
3 nervous system MP:0003631 9.56 BDNF CCKAR COMT DRD5 MAOA NTRK2
4 taste/olfaction MP:0005394 8.8 BDNF CCKAR TPH2

Drugs & Therapeutics for Paranoid Schizophrenia

Drugs for Paranoid Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cycloserine Approved Phase 4 68-41-7 401 6234
2 Anti-Bacterial Agents Phase 4
3 Antimetabolites Phase 4
4 Anti-Infective Agents Phase 4
5 Antibiotics, Antitubercular Phase 4
6 Anti-Infective Agents, Urinary Phase 4
7 Antitubercular Agents Phase 4
8 Renal Agents Phase 4
9
Risperidone Approved, Investigational Phase 2,Not Applicable 106266-06-2 5073
10
Amisulpride Approved, Investigational Phase 2 71675-85-9, 53583-79-2 2159
11
Aripiprazole Approved, Investigational Phase 2 129722-12-9 60795
12
Olanzapine Approved, Investigational Phase 2 132539-06-1 4585
13 Antipsychotic Agents Phase 2,Not Applicable
14 Epidiolex Phase 2
15 Anticonvulsants Phase 2
16 Quetiapine Fumarate Phase 2 111974-72-2
17
Dopamine Approved Not Applicable 62-31-7, 51-61-6 681
18 Central Nervous System Depressants Not Applicable
19 Dopamine Agents Not Applicable
20 Psychotropic Drugs Not Applicable
21 Neurotransmitter Agents Not Applicable
22 Serotonin Agents Not Applicable
23 Serotonin Antagonists Not Applicable
24 Dopamine Antagonists Not Applicable
25 Tranquilizing Agents Not Applicable
26
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Using D-cycloserine to Enhance the Benefits of Cognitive Behavioral Therapy for Schizophrenia Completed NCT00742079 Phase 4 D-cycloserine
2 MK0249 for the Treatment of Cognitive Impairment in Patients With Schizophrenia (0249-016) Completed NCT00506077 Phase 2 MK0249;Comparator: Placebo (unspecified)
3 MK0557 for the Treatment of Cognitive Impairment in Patients With Schizophrenia (0557-027) Completed NCT00482430 Phase 2 MK0557;Comparator: Placebo (unspecified)
4 Transcutaneous Non-invasive Vagus Nerve Stimulation (t-VNS) in the Treatment of Schizophrenia Completed NCT01176721 Phase 2
5 Enhancing Recovery in Early Schizophrenia Recruiting NCT02926859 Phase 2 Cannabidiol as add-on;Placebo as add-on
6 Evaluation of Efficacy and Safety of Long-acting Risperidone Microspheres in Patients With Schizophrenia or Other Psychotic Disorders When Switching From Typical Antipsychotic (Oral/Depot) or Atypical Oral Other Than Risperidone Unknown status NCT00563017 Not Applicable Long-acting Risperidone microspheres injection

Search NIH Clinical Center for Paranoid Schizophrenia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: schizophrenia, paranoid

Genetic Tests for Paranoid Schizophrenia

Anatomical Context for Paranoid Schizophrenia

MalaCards organs/tissues related to Paranoid Schizophrenia:

42
Testes, Brain, Eye, Pituitary, Thyroid, Cortex, Prefrontal Cortex

Publications for Paranoid Schizophrenia

Articles related to Paranoid Schizophrenia:

(show top 50) (show all 330)
# Title Authors Year
1
Psychoeducational therapy with families of paranoid schizophrenia patients. ( 30745183 )
2019
2
Paranoid schizophrenia and methamphetamine-induced paranoia are both characterized by a similar LINE-1 partial methylation profile, which is more pronounced in paranoid schizophrenia. ( 30826260 )
2019
3
Zotepine-induced convulsion at a low dose in a case of paranoid schizophrenia. ( 29363876 )
2018
4
The difficulties of secondary prophylaxis of cervical cancer in women suffering from paranoid schizophrenia - a case study. ( 29975365 )
2018
5
Altered corticostriatal pathway in first-episode paranoid schizophrenia: Resting-state functional and causal connectivity analyses. ( 29122402 )
2018
6
A telemedicine platform to improve clinical parameters in paranoid schizophrenia patients: Results of a one-year randomized study. ( 30154027 )
2018
7
Comparative study of aggression - Dangerousness on patients with paranoid schizophrenia: Focus on demographic data, PANSS, drug use and aggressiveness. ( 30217324 )
2018
8
Adherence, insight and disability in paranoid schizophrenia. ( 30278408 )
2018
9
Low levels of serum total antioxidant capacity and presence at admission and absence at discharge of a day/night change as a marker of acute paranoid schizophrenia relapse. ( 28126575 )
2017
10
Cognitive deficit in patients with paranoid schizophrenia: Its clinical and laboratory correlates. ( 28951142 )
2017
11
Successful treatment with risperidone increases 5-HT 3A receptor gene expression in patients with paranoid schizophrenia - data from a prospective study. ( 28948091 )
2017
12
Association of the IFN-I^ (+874A/T) Genetic Polymorphism with Paranoid Schizophrenia in Tunisian Population. ( 27819519 )
2017
13
Short Sleep in Patients With Chronic Paranoid Schizophrenia. ( 28841274 )
2017
14
A three-month longitudinal study of changes in day/night serum total antioxidant capacity in paranoid schizophrenia. ( 29220388 )
2017
15
Day/night changes in serum S100B protein concentrations in acute paranoid schizophrenia. ( 28188811 )
2017
16
Treatment Compliance in the Long-Term Paranoid Schizophrenia Telemedicine Study. ( 29082310 )
2017
17
Intracranial Foreign Body in a Patient With Paranoid Schizophrenia. ( 28885436 )
2017
18
Paranoid schizophrenia in a woman with Marfan syndrome. ( 29424882 )
2017
19
Evidence for Distinguishable Treatment Costs among Paranoid Schizophrenia and Schizoaffective Disorder. ( 27391238 )
2016
20
Variants in TERT influencing telomere length are associated with paranoid schizophrenia risk. ( 26799699 )
2016
21
Huntington's disease in a patient with 15-year history of Capgras delusion misdiagnosed as paranoid schizophrenia. ( 26719104 )
2016
22
Discriminating between first- and second-order cognition in first-episode paranoid schizophrenia. ( 28005458 )
2016
23
IFNGR2 genetic polymorphism associated with sex-specific paranoid schizophrenia risk. ( 27563937 )
2016
24
[PSYCHOEDUCATIONAL PROGRAM AS A WAY OF CORRECTING MOTIVATIONAL COMPONENTS IN PATIENTS WITH PARANOID SCHIZOPHRENIA WITH ABDOMINAL OBESITY]. ( 26870976 )
2016
25
GABAergic system impairment in the hippocampus and superior temporal gyrus of patients with paranoid schizophrenia: A post-mortem study. ( 26922657 )
2016
26
Genetic variants in long non-coding RNA MIAT contribute to risk of paranoid schizophrenia in a Chinese Han population. ( 26004688 )
2015
27
Chronic non-fatal Datura abuse in a patient of paranoid schizophrenia: a case report. ( 25544354 )
2015
28
Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients. ( 26925374 )
2015
29
Paranoid Schizophrenia versus Schizoaffective Disorder: Neuropsychological Aspects. ( 26506747 )
2015
30
Evidence from paranoid schizophrenia for more than one component of theory of mind. ( 26579026 )
2015
31
Long term telemedicine study of compliance in paranoid schizophrenia. ( 26417777 )
2015
32
[The Role of Neurotrophins and Neurexins Genes in the Risk of Paranoid Schizophrenia in Russians and Tatars]. ( 26410934 )
2015
33
Spinocerebellar ataxia-10 with paranoid schizophrenia. ( 25745322 )
2015
34
Abnormal inter- and intra-hemispheric integration in male paranoid schizophrenia: a graph-theoretical analysis. ( 26300598 )
2015
35
A paired case-control comparison of ziprasidone on visual sustained attention and visual selective attention in patients with paranoid schizophrenia. ( 26367712 )
2015
36
Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia. ( 26315603 )
2015
37
A novel psychoactive substance poses a new challenge in the management of paranoid schizophrenia. ( 25948854 )
2015
38
Facial emotion recognition in paranoid schizophrenia and autism spectrum disorder. ( 25278104 )
2014
39
Is the comprehension of idiomatic sentences indeed impaired in paranoid Schizophrenia? A window into semantic processing deficits. ( 25346676 )
2014
40
Clozapine induced tubulointerstitial nephritis in a patient with paranoid schizophrenia. ( 24849641 )
2014
41
[Glutamate receptors genes polymorphism and the risk of paranoid schizophrenia in Russians and tatars from the Republic of Bashkortostan]. ( 25842862 )
2014
42
Decreased resting-state interhemispheric coordination in first-episode, drug-naive paranoid schizophrenia. ( 24075897 )
2014
43
Rapid Response of Long-Standing, Treatment-Resistant Non-Catatonic Mutism in Paranoid Schizophrenia with Single ECT session. ( 25535609 )
2014
44
Alcohol abuse as the strongest risk factor for violent offending in patients with paranoid schizophrenia. ( 24778102 )
2014
45
[The association of polymorphisms in SLC18A1, TPH1 and RELN genes with risk of paranoid schizophrenia]. ( 25842846 )
2014
46
Hiccups associated with switching from olanzapine to aripiprazole in a patient with paranoid schizophrenia. ( 24824665 )
2014
47
Genetic association between the dopamine D1-receptor gene and paranoid schizophrenia in a northern Han Chinese population. ( 24790447 )
2014
48
Cognitive restructuring and graded behavioural exposure for delusional appraisals of auditory hallucinations and comorbid anxiety in paranoid schizophrenia. ( 25302129 )
2014
49
EEG Theta Power and Coherence to Octave Illusion in First-Episode Paranoid Schizophrenia with Auditory Hallucinations. ( 25359515 )
2014
50
Ribosomal DNA transcription in the dorsal raphe nucleus is increased in residual but not in paranoid schizophrenia. ( 25091423 )
2014

Variations for Paranoid Schizophrenia

Expression for Paranoid Schizophrenia

Search GEO for disease gene expression data for Paranoid Schizophrenia.

Pathways for Paranoid Schizophrenia

GO Terms for Paranoid Schizophrenia

Cellular components related to Paranoid Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.26 BDNF COMT HTR2A NTRK2
2 axon GO:0030424 8.92 BDNF COMT HTR2A NTRK2

Biological processes related to Paranoid Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 circadian rhythm GO:0007623 9.54 NTRK2 SLC6A4 TPH2
2 memory GO:0007613 9.5 BDNF HTR2A SLC6A4
3 feeding behavior GO:0007631 9.48 CCKAR NTRK2
4 neurotrophin TRK receptor signaling pathway GO:0048011 9.46 BDNF NTRK2
5 catecholamine metabolic process GO:0006584 9.43 COMT MAOA
6 neurotransmitter catabolic process GO:0042135 9.4 COMT MAOA
7 dopamine catabolic process GO:0042420 9.26 COMT MAOA
8 positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997 9.16 BDNF NTRK2
9 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 8.96 BDNF NTRK2
10 activation of phospholipase C activity GO:0007202 8.8 BDNF HTR2A NTRK2

Molecular functions related to Paranoid Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein alpha-subunit binding GO:0001965 8.96 DRD5 HTR2A
2 serotonin binding GO:0051378 8.62 HTR2A SLC6A4

Sources for Paranoid Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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