MCID: PRN009
MIFTS: 47

Paranoid Schizophrenia

Categories: Mental diseases

Aliases & Classifications for Paranoid Schizophrenia

MalaCards integrated aliases for Paranoid Schizophrenia:

Name: Paranoid Schizophrenia 12 55 15 73
Chronic Paranoid Schizophrenia 12 73
Paranoid Type Schizophrenia Subchronic State 12
Paranoid Type Schizophrenia 12
Paraphrenic Schizophrenia 12
Schizophrenia, Paranoid 44
Paraphrenia - Late 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1229
ICD10 33 F20.0
MeSH 44 D012563
NCIt 50 C35006
SNOMED-CT 68 31658008 64905009

Summaries for Paranoid Schizophrenia

Disease Ontology : 12 A schizophrenia characterized by delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.

MalaCards based summary : Paranoid Schizophrenia, also known as chronic paranoid schizophrenia, is related to schizophrenia and depression. An important gene associated with Paranoid Schizophrenia is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways are MAPK signaling pathway and Serotonergic synapse. The drugs Cycloserine and Antitubercular Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, cortex and brain, and related phenotypes are behavior/neurological and taste/olfaction

Wikipedia : 76 Paranoid schizophrenia is the most common type of schizophrenia. Schizophrenia is defined as �??a... more...

Related Diseases for Paranoid Schizophrenia

Diseases related to Paranoid Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 30.4 BDNF CCKAR COMT HTR2A MAOA MIAT
2 depression 30.2 BDNF HTR2A MAOA SLC6A4 TPH2
3 traumatic brain injury 30.0 BDNF COMT
4 brain injury 30.0 BDNF COMT
5 alexithymia 30.0 COMT SLC6A4
6 schizoaffective disorder 30.0 BDNF COMT HTR2A SLC6A4
7 alcohol abuse 29.8 BDNF HTR2A SLC6A4
8 personality disorder 29.8 BDNF COMT HTR2A MAOA SLC6A4
9 anxiety 29.8 BDNF COMT HTR2A MAOA SLC6A4 TPH2
10 psychotic disorder 29.7 BDNF COMT HTR2A SLC6A4
11 autism spectrum disorder 29.7 BDNF HTR2A SLC6A4 TPH2
12 post-traumatic stress disorder 29.6 BDNF COMT HTR2A MAOA SLC6A4
13 mood disorder 29.4 BDNF COMT HTR2A MAOA SLC6A4 TPH2
14 obsessive-compulsive disorder 29.4 BDNF COMT HTR2A MAOA SLC6A4 TPH2
15 alcohol dependence 29.4 BDNF COMT HTR2A MAOA SLC6A4 TPH2
16 autism 29.4 BDNF COMT HTR2A MAOA SLC6A4 TPH2
17 major depressive disorder 29.2 BDNF COMT HTR2A MAOA NTRK2 SLC6A4
18 phobia, specific 10.2 COMT MAOA
19 tic disorder 10.2 HTR2A TPH2
20 schizophrenia 5 10.2 COMT HTR2A
21 early-onset schizophrenia 10.2 BDNF HTR2A
22 tardive dyskinesia 10.2 COMT HTR2A
23 nodular ganglioneuroblastoma 10.2 BDNF NTRK2
24 vertebral artery occlusion 10.1 BDNF NTRK2
25 dystonia 1, torsion, autosomal dominant 10.1 COMT MAOA
26 hypogonadotropic hypogonadism 10.1
27 epilepsy 10.1
28 mutism 10.1
29 delusional disorder 10.1
30 avoidant personality disorder 10.1 MAOA SLC6A4
31 social phobia 10.1 MAOA SLC6A4
32 kleptomania 10.1 MAOA SLC6A4
33 premature ejaculation 10.0 COMT SLC6A4
34 psychosexual disorder 10.0 HTR2A SLC6A4
35 opioid addiction 10.0 CCKAR COMT
36 alcoholic psychosis 10.0 HTR2A SLC6A4
37 periodic limb movement disorder 10.0 HTR2A SLC6A4
38 phobic disorder 10.0 COMT MAOA SLC6A4
39 agoraphobia 10.0 MAOA SLC6A4
40 brunner syndrome 10.0 COMT MAOA SLC6A4
41 antisocial personality disorder 10.0 COMT MAOA SLC6A4
42 conduct disorder 10.0 COMT MAOA SLC6A4
43 eating disorder 10.0 BDNF COMT SLC6A4
44 specific developmental disorder 10.0 BDNF COMT SLC6A4
45 atypical depressive disorder 10.0 HTR2A MAOA SLC6A4
46 substance dependence 10.0 BDNF MAOA SLC6A4
47 dysthymic disorder 10.0 HTR2A MAOA SLC6A4
48 fibromyalgia 10.0 COMT HTR2A SLC6A4
49 pathological gambling 10.0 HTR2A MAOA SLC6A4
50 serotonin syndrome 10.0 HTR2A MAOA SLC6A4

Comorbidity relations with Paranoid Schizophrenia via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Alzheimer Disease
Deficiency Anemia Delusional Disorder
Hypertension, Essential Hypothyroidism
Major Depressive Disorder Paranoid Personality Disorder
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Schizophrenia Schizophreniform Disorder
Tardive Dyskinesia

Graphical network of the top 20 diseases related to Paranoid Schizophrenia:



Diseases related to Paranoid Schizophrenia

Symptoms & Phenotypes for Paranoid Schizophrenia

MGI Mouse Phenotypes related to Paranoid Schizophrenia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 BDNF CCKAR COMT HTR2A MAOA NTRK2
2 taste/olfaction MP:0005394 8.8 BDNF CCKAR TPH2

Drugs & Therapeutics for Paranoid Schizophrenia

Drugs for Paranoid Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cycloserine Approved Phase 4 68-41-7 6234 401
2 Antitubercular Agents Phase 4
3 Anti-Infective Agents, Urinary Phase 4
4 Anti-Bacterial Agents Phase 4
5 Renal Agents Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Antimetabolites Phase 4
8 Anti-Infective Agents Phase 4
9
Risperidone Approved, Investigational Phase 2,Not Applicable 106266-06-2 5073
10
Aripiprazole Approved, Investigational Phase 2 129722-12-9 60795
11
Olanzapine Approved, Investigational Phase 2 132539-06-1 4585
12 Antipsychotic Agents Phase 2,Not Applicable
13 Quetiapine Fumarate Phase 2 111974-72-2
14 sultopride Phase 2
15
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
16 Psychotropic Drugs Not Applicable
17 Serotonin Agents Not Applicable
18 Dopamine Antagonists Not Applicable
19 Central Nervous System Depressants Not Applicable
20 Serotonin Antagonists Not Applicable
21 Neurotransmitter Agents Not Applicable
22 Dopamine Agents Not Applicable
23 Tranquilizing Agents Not Applicable
24
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Using D-cycloserine to Enhance the Benefits of Cognitive Behavioral Therapy for Schizophrenia Completed NCT00742079 Phase 4 D-cycloserine
2 MK0249 for the Treatment of Cognitive Impairment in Patients With Schizophrenia (0249-016) Completed NCT00506077 Phase 2 MK0249;Comparator: Placebo (unspecified)
3 MK0557 for the Treatment of Cognitive Impairment in Patients With Schizophrenia (0557-027) Completed NCT00482430 Phase 2 MK0557;Comparator: Placebo (unspecified)
4 Transcutaneous Non-invasive Vagus Nerve Stimulation (t-VNS) in the Treatment of Schizophrenia Completed NCT01176721 Phase 2
5 Enhancing Recovery in Early Schizophrenia Recruiting NCT02926859 Phase 2 Cannabidiol as add-on;Placebo as add-on
6 Evaluation of Efficacy and Safety of Long-acting Risperidone Microspheres in Patients With Schizophrenia or Other Psychotic Disorders When Switching From Typical Antipsychotic (Oral/Depot) or Atypical Oral Other Than Risperidone Unknown status NCT00563017 Not Applicable Long-acting Risperidone microspheres injection

Search NIH Clinical Center for Paranoid Schizophrenia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: schizophrenia, paranoid

Genetic Tests for Paranoid Schizophrenia

Anatomical Context for Paranoid Schizophrenia

MalaCards organs/tissues related to Paranoid Schizophrenia:

41
Testes, Cortex, Brain, Eye, Pituitary, Thyroid, Prefrontal Cortex

Publications for Paranoid Schizophrenia

Articles related to Paranoid Schizophrenia:

(show top 50) (show all 327)
# Title Authors Year
1
Zotepine-induced convulsion at a low dose in a case of paranoid schizophrenia. ( 29363876 )
2018
2
The difficulties of secondary prophylaxis of cervical cancer in women suffering from paranoid schizophrenia - a case study. ( 29975365 )
2018
3
Altered corticostriatal pathway in first-episode paranoid schizophrenia: Resting-state functional and causal connectivity analyses. ( 29122402 )
2018
4
A telemedicine platform to improve clinical parameters in paranoid schizophrenia patients: Results of a one-year randomized study. ( 30154027 )
2018
5
Comparative study of aggression - Dangerousness on patients with paranoid schizophrenia: Focus on demographic data, PANSS, drug use and aggressiveness. ( 30217324 )
2018
6
Adherence, insight and disability in paranoid schizophrenia. ( 30278408 )
2018
7
Low levels of serum total antioxidant capacity and presence at admission and absence at discharge of a day/night change as a marker of acute paranoid schizophrenia relapse. ( 28126575 )
2017
8
Cognitive deficit in patients with paranoid schizophrenia: Its clinical and laboratory correlates. ( 28951142 )
2017
9
Successful treatment with risperidone increases 5-HT 3A receptor gene expression in patients with paranoid schizophrenia - data from a prospective study. ( 28948091 )
2017
10
Association of the IFN-I^ (+874A/T) Genetic Polymorphism with Paranoid Schizophrenia in Tunisian Population. ( 27819519 )
2017
11
Short Sleep in Patients With Chronic Paranoid Schizophrenia. ( 28841274 )
2017
12
A three-month longitudinal study of changes in day/night serum total antioxidant capacity in paranoid schizophrenia. ( 29220388 )
2017
13
Day/night changes in serum S100B protein concentrations in acute paranoid schizophrenia. ( 28188811 )
2017
14
Treatment Compliance in the Long-Term Paranoid Schizophrenia Telemedicine Study. ( 29082310 )
2017
15
Paranoid schizophrenia in a woman with Marfan syndrome. ( 29424882 )
2017
16
Intracranial Foreign Body in a Patient With Paranoid Schizophrenia. ( 28885436 )
2017
17
Evidence for Distinguishable Treatment Costs among Paranoid Schizophrenia and Schizoaffective Disorder. ( 27391238 )
2016
18
Variants in TERT influencing telomere length are associated with paranoid schizophrenia risk. ( 26799699 )
2016
19
Huntington's disease in a patient with 15-year history of Capgras delusion misdiagnosed as paranoid schizophrenia. ( 26719104 )
2016
20
Discriminating between first- and second-order cognition in first-episode paranoid schizophrenia. ( 28005458 )
2016
21
IFNGR2 genetic polymorphism associated with sex-specific paranoid schizophrenia risk. ( 27563937 )
2016
22
[PSYCHOEDUCATIONAL PROGRAM AS A WAY OF CORRECTING MOTIVATIONAL COMPONENTS IN PATIENTS WITH PARANOID SCHIZOPHRENIA WITH ABDOMINAL OBESITY]. ( 26870976 )
2016
23
GABAergic system impairment in the hippocampus and superior temporal gyrus of patients with paranoid schizophrenia: A post-mortem study. ( 26922657 )
2016
24
Genetic variants in long non-coding RNA MIAT contribute to risk of paranoid schizophrenia in a Chinese Han population. ( 26004688 )
2015
25
Chronic non-fatal Datura abuse in a patient of paranoid schizophrenia: a case report. ( 25544354 )
2015
26
Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients. ( 26925374 )
2015
27
Paranoid Schizophrenia versus Schizoaffective Disorder: Neuropsychological Aspects. ( 26506747 )
2015
28
Evidence from paranoid schizophrenia for more than one component of theory of mind. ( 26579026 )
2015
29
Long term telemedicine study of compliance in paranoid schizophrenia. ( 26417777 )
2015
30
[The Role of Neurotrophins and Neurexins Genes in the Risk of Paranoid Schizophrenia in Russians and Tatars]. ( 26410934 )
2015
31
Spinocerebellar ataxia-10 with paranoid schizophrenia. ( 25745322 )
2015
32
Abnormal inter- and intra-hemispheric integration in male paranoid schizophrenia: a graph-theoretical analysis. ( 26300598 )
2015
33
A paired case-control comparison of ziprasidone on visual sustained attention and visual selective attention in patients with paranoid schizophrenia. ( 26367712 )
2015
34
Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia. ( 26315603 )
2015
35
A novel psychoactive substance poses a new challenge in the management of paranoid schizophrenia. ( 25948854 )
2015
36
Facial emotion recognition in paranoid schizophrenia and autism spectrum disorder. ( 25278104 )
2014
37
Is the comprehension of idiomatic sentences indeed impaired in paranoid Schizophrenia? A window into semantic processing deficits. ( 25346676 )
2014
38
Clozapine induced tubulointerstitial nephritis in a patient with paranoid schizophrenia. ( 24849641 )
2014
39
[Glutamate receptors genes polymorphism and the risk of paranoid schizophrenia in Russians and tatars from the Republic of Bashkortostan]. ( 25842862 )
2014
40
Decreased resting-state interhemispheric coordination in first-episode, drug-naive paranoid schizophrenia. ( 24075897 )
2014
41
Rapid Response of Long-Standing, Treatment-Resistant Non-Catatonic Mutism in Paranoid Schizophrenia with Single ECT session. ( 25535609 )
2014
42
Alcohol abuse as the strongest risk factor for violent offending in patients with paranoid schizophrenia. ( 24778102 )
2014
43
[The association of polymorphisms in SLC18A1, TPH1 and RELN genes with risk of paranoid schizophrenia]. ( 25842846 )
2014
44
Hiccups associated with switching from olanzapine to aripiprazole in a patient with paranoid schizophrenia. ( 24824665 )
2014
45
Genetic association between the dopamine D1-receptor gene and paranoid schizophrenia in a northern Han Chinese population. ( 24790447 )
2014
46
Cognitive restructuring and graded behavioural exposure for delusional appraisals of auditory hallucinations and comorbid anxiety in paranoid schizophrenia. ( 25302129 )
2014
47
EEG Theta Power and Coherence to Octave Illusion in First-Episode Paranoid Schizophrenia with Auditory Hallucinations. ( 25359515 )
2014
48
Ribosomal DNA transcription in the dorsal raphe nucleus is increased in residual but not in paranoid schizophrenia. ( 25091423 )
2014
49
Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese. ( 24668635 )
2014
50
Subjective experience of emotions and emotional empathy in paranoid schizophrenia. ( 25288043 )
2014

Variations for Paranoid Schizophrenia

Expression for Paranoid Schizophrenia

Search GEO for disease gene expression data for Paranoid Schizophrenia.

Pathways for Paranoid Schizophrenia

Pathways related to Paranoid Schizophrenia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1 12.43 BDNF HSPA1B HSPA1L NTRK2
2 11.52 HTR2A MAOA SLC6A4 TPH2
3 11.31 BDNF HTR2A MAOA NTRK2 SLC6A4 TPH2
4 11.15 HSPA1B HSPA1L
5
Show member pathways
11.13 MAOA SLC6A4 TPH2
6
Show member pathways
11.12 HSPA1B HSPA1L
7 11.05 HSPA1B HSPA1L
8 11.03 BDNF NTRK2
9
Show member pathways
10.85 COMT MAOA SLC6A4
10
Show member pathways
10.82 COMT MAOA
11 10.7 HTR2A MAOA SLC6A4 TPH2
12
Show member pathways
10.61 COMT MAOA
13 10.55 COMT MAOA
14 10.51 BDNF NTRK2

GO Terms for Paranoid Schizophrenia

Cellular components related to Paranoid Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.26 BDNF COMT HTR2A NTRK2
2 COP9 signalosome GO:0008180 9.16 HSPA1B HSPA1L
3 axon GO:0030424 8.92 BDNF COMT HTR2A NTRK2

Biological processes related to Paranoid Schizophrenia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of cellular response to heat GO:1900034 9.54 HSPA1B HSPA1L
2 circadian rhythm GO:0007623 9.54 NTRK2 SLC6A4 TPH2
3 feeding behavior GO:0007631 9.52 CCKAR NTRK2
4 chaperone cofactor-dependent protein refolding GO:0051085 9.51 HSPA1B HSPA1L
5 memory GO:0007613 9.5 BDNF HTR2A SLC6A4
6 cellular response to unfolded protein GO:0034620 9.49 HSPA1B HSPA1L
7 protein refolding GO:0042026 9.48 HSPA1B HSPA1L
8 neurotrophin TRK receptor signaling pathway GO:0048011 9.46 BDNF NTRK2
9 catecholamine metabolic process GO:0006584 9.43 COMT MAOA
10 neurotransmitter catabolic process GO:0042135 9.4 COMT MAOA
11 dopamine catabolic process GO:0042420 9.26 COMT MAOA
12 positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997 9.16 BDNF NTRK2
13 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 8.96 BDNF NTRK2
14 activation of phospholipase C activity GO:0007202 8.8 BDNF HTR2A NTRK2

Molecular functions related to Paranoid Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 misfolded protein binding GO:0051787 9.26 HSPA1B HSPA1L
2 protein binding involved in protein folding GO:0044183 9.16 HSPA1B HSPA1L
3 ATPase activity, coupled GO:0042623 8.96 HSPA1B HSPA1L
4 serotonin binding GO:0051378 8.62 HTR2A SLC6A4

Sources for Paranoid Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....