MCID: PRP015
MIFTS: 33

Paraphilia Disorder

Categories: Mental diseases

Aliases & Classifications for Paraphilia Disorder

MalaCards integrated aliases for Paraphilia Disorder:

Name: Paraphilia Disorder 12 15
Paraphilias 70
Paraphilia 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060044
UMLS 70 C0030482

Summaries for Paraphilia Disorder

Disease Ontology : 12 A sexual disorder that is characterized recurrent, intense sexually arousing fantasies, sexual urges or behaviors generally involving nonhuman objects.

MalaCards based summary : Paraphilia Disorder, also known as paraphilias, is related to bestiality and sexual sadism. An important gene associated with Paraphilia Disorder is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are Circadian rythm related genes and Monoamine Transport. The drugs Leuprolide and Hormones have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and temporal lobe.

Wikipedia : 73 Paraphilia (previously known as sexual perversion and sexual deviation) is the experience of intense... more...

Related Diseases for Paraphilia Disorder

Diseases related to Paraphilia Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 bestiality 31.3 OXT MAOA DRD4 DRD2
2 sexual sadism 30.7 OXT MAOA
3 voyeurism 30.3 TTC12 MAOA
4 sexual disorder 30.2 SLC6A4 OXT H2AC18
5 kluver-bucy syndrome 30.1 OXT GRN
6 alcohol use disorder 30.0 SLC6A4 H2AC18 DRD2
7 dysthymic disorder 30.0 SLC6A4 MAOA DRD4
8 fetishism 30.0 OXT H2AC18 H1-5
9 cocaine abuse 29.9 SLC6A4 H2AC18 DRD2
10 social phobia 29.9 SLC6A4 OXT MAOA DRD2
11 trichotillomania 29.9 MAOA DRD4
12 pedophilia 29.9 TTC12 OXT MIR545 MAOA GRN
13 transvestism 29.7 OXT H2AC18 H1-5
14 generalized anxiety disorder 29.7 SLC6A4 MAOA DRD2
15 personality disorder 29.6 SLC6A4 MAOA DRD4 DRD2
16 mood disorder 29.6 SLC6A4 MAOA H2AC18 DRD4 DRD2
17 substance abuse 29.5 SLC6A4 MAOA H2AC18 DRD4 DRD2
18 pervasive developmental disorder 29.4 SLC6A4 OXT H2AC18 DRD2
19 attention deficit-hyperactivity disorder 29.4 SLC6A4 OXT MAOA DRD4 DRD2
20 impulse control disorder 29.3 SLC6A4 MAOA GRN DRD4 DRD2
21 conduct disorder 29.3 SLC6A4 MAOA DRD4 DRD2
22 bipolar disorder 29.1 SLC6A4 MAOA DRD4 DRD2
23 antisocial personality disorder 29.1 SLC6A4 OXT MAOA DRD4 DRD2
24 anxiety 29.1 SLC6A4 OXT MAOA DRD4 DRD2
25 mental depression 28.9 SLC6A4 OXT MAOA H2AC18 DRD4 DRD2
26 obsessive-compulsive disorder 28.8 SLC6A4 OXT MAOA GRN DRD4 DRD2
27 exhibitionism 28.8 TTC12 OSTF1 MAOA H2AC18 DRD4 ADD2
28 flying phobia 10.3 OXT MAOA
29 prosopagnosia 10.2 OXT GRN
30 dependent personality disorder 10.2 MAOA DRD4
31 actinomycosis 10.2 OSTF1 H2AC18
32 animal phobia 10.1 SLC6A4 OXT
33 epithelial-stromal tgfbi dystrophy 10.1 OSTF1 H2AC18
34 inhibited male orgasm 10.1 SLC6A4 OXT
35 tardive dyskinesia 10.1 DRD4 DRD2
36 atypical depressive disorder 10.1 SLC6A4 MAOA
37 somatization disorder 10.1 SLC6A4 OXT
38 hallucinogen dependence 10.1 TTC12 DRD2
39 psychosexual disorder 10.1 SLC6A4 OXT
40 narcissistic personality disorder 10.1 OXT OSTF1 MAOA
41 alcohol-induced mental disorder 10.1 SLC6A4 DRD2
42 hypochondriasis 10.1 SLC6A4 OXT
43 adjustment disorder 10.1 SLC6A4 OXT
44 delusional disorder 10.1 DRD4 DRD2
45 speech disorder 10.1 H2AC18 GRN DRD2
46 melancholia 10.1 SLC6A4 MAOA
47 substance-induced psychosis 10.1 SLC6A4 DRD2
48 acute stress disorder 10.1 SLC6A4 OXT
49 brunner syndrome 10.1 SLC6A4 MAOA
50 cannabis abuse 10.1 DRD4 DRD2

Graphical network of the top 20 diseases related to Paraphilia Disorder:



Diseases related to Paraphilia Disorder

Symptoms & Phenotypes for Paraphilia Disorder

Drugs & Therapeutics for Paraphilia Disorder

Drugs for Paraphilia Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Leuprolide Approved, Investigational Phase 1 53714-56-0 3911 657181
2 Hormones Phase 1
3 Hormone Antagonists Phase 1
4
Testosterone Approved, Investigational 58-22-0 6013
5 Androgens
6 Androgen Antagonists
7 Liver Extracts
8
Bilirubin 635-65-4 5280352

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cognitive Group and Hormonal Treatment of Sex Offenders. Terminated NCT00379626 Phase 1 cognitive and hormone treatment
2 Descriptive Study on the Impact of Covid-19 Lockdown on Deviant Sexual Fantasies Completed NCT04448405
3 A Retrospective Non-interventional Descriptive Epidemiology Study for Patients With Paraphilia Sex Offenders Receiving Androgen Antagonists Treatment Completed NCT01743209
4 Study of Maintenance of the Efficiency and Adverse Effects of Pharmacological Treatments in Sex Offenders With Paraphilia Not yet recruiting NCT04316650

Search NIH Clinical Center for Paraphilia Disorder

Genetic Tests for Paraphilia Disorder

Anatomical Context for Paraphilia Disorder

MalaCards organs/tissues related to Paraphilia Disorder:

40
Brain, Bone, Temporal Lobe, Liver

Publications for Paraphilia Disorder

Articles related to Paraphilia Disorder:

(show top 50) (show all 298)
# Title Authors PMID Year
1
Forensic Evaluation of Sexsomnia. 61
33579735 2021
2
Compulsive Conditioned Sexual Responding of Male Japanese Quail in Extinction. 61
33398697 2021
3
The Prevalence of Paraphilic Interests in the Czech Population: Preference, Arousal, the Use of Pornography, Fantasy, and Behavior. 61
31916860 2021
4
Association of ADHD and hypersexuality and paraphilias. 61
33333439 2021
5
Psychiatric and Forensic Differences Between Men Charged with Sex Offences and Men Charged with Other Offences. 61
33180341 2020
6
The Application of Community-Based Participatory Action Research to the Study of Paraphilias. 61
32524315 2020
7
Internet-Administered Cognitive Behavioral Therapy for Hypersexual Disorder, With or Without Paraphilia(s) or Paraphilic Disorder(s) in Men: A Pilot Study. 61
32900671 2020
8
Conditioning of Sexual Interests and Paraphilias in Humans Is Difficult to See, Virtually Impossible to Test, and Probably Exactly How It Happens: A Comment on Hsu and Bailey (2020). 61
32462414 2020
9
Paraphilias among Roman Catholic priests: what we know, and do not know, about sexual clergy-abusers of minors. 61
33038888 2020
10
Conceptualization, History, and Future of the Paraphilias. 61
32023092 2020
11
Stigmatization of Paraphilias and Psychological Conditions Linked to Sexual Offending. 61
32352329 2020
12
Erotic Target Identity Inversions Among Men and Women in an Internet Sample. 61
31813772 2020
13
Hypersexuality Manifesting as Excessive Masturbation in a Female Patient After Temporal Lobe Epileptic Surgery: A Rare Case Report. 61
31903044 2019
14
Sex Offenders in Croatia: Fifteen Years Later. 61
32160179 2019
15
DSM-5 paraphilic disorders criteria in the light of autoerotic asphyxiophilia and non-sexual form of oxygen restriction. 61
31955188 2019
16
Sexuality in the 21st century: Leather or rubber? Fetishism explained. 61
31065177 2019
17
Paraphilias and the press: Do not always believe what you read! 61
31065198 2019
18
DSM-5, Paraphilias, and the Paraphilic Disorders: Confusion Reigns. 61
30790206 2019
19
Fanon and the New Paraphilias: Towards a Trans of Color Critique of the DSM-V. 61
30076507 2019
20
Contemporary understanding of zoophilia - A multinational survey study. 61
30639855 2019
21
Same Same but Different: A Clinical Characterization of Men with Hypersexual Disorder in the Sex@Brain Study. 61
30704084 2019
22
Digital Ethnography of Zoophilia - A Multinational Mixed-Methods Study. 61
29746216 2019
23
Deviance or Normalcy? The Relationship Among Paraphilic Thoughts and Behaviors, Hypersexuality, and Psychopathology in a Sample of University Students. 61
30224020 2018
24
Diagnostic Issues in the Paraphilias. 61
30032364 2018
25
Clinical characteristics associated with paedophilia and child sex offending - Differentiating sexual preference from offence status. 61
29625377 2018
26
Paraphilic infantilism, diaperism and pedophilia: A review. 61
29525580 2018
27
Paraphilias and the ICD-11: Progress but Still Logically Inconsistent. 61
29294228 2018
28
Sex on the Silver Screen: Using Film to Teach About Paraphilias. 61
28685351 2018
29
Affective disorders and sexual function: from neuroscience to clinic. 61
28806269 2017
30
The Development of In Vivo Measures to Assess the Impact of Sex-Drive Reducing Medications in an Offender with an Intellectual Disability. 61
27671782 2017
31
The Puzzle of Male Chronophilias. 61
27549306 2017
32
Cognitional Impairment: Is There a Role for Cognitive Assessment in the Treatment of Individuals Civilly Committed Pursuant to the Sexually Violent Predator Act? 61
25698358 2016
33
Aspects of Sexuality in Adolescents and Adults Diagnosed with Autism Spectrum Disorders in Childhood. 61
27401993 2016
34
Paraphilic Sexual Interests and Sexually Coercive Behavior: A Population-Based Twin Study. 61
26754158 2016
35
Genetic Variants Associated With Male Pedophilic Sexual Interest. 61
27114195 2016
36
Psychosexual disorders and dermatologists. 61
27294047 2016
37
More Than a Nuisance: The Prevalence and Consequences of Frotteurism and Exhibitionism. 61
24598839 2016
38
Paraphilic Interests: An Examination of Sex Differences in a Nonclinical Sample. 61
24633420 2016
39
Paraphilias in the DSM-5. 61
26772210 2016
40
Sexual Masochism Disorder with Asphyxiophilia: A Deadly yet Underrecognized Disease. 61
27747123 2016
41
Paraphilias. 61
26382165 2015
42
Sexual disorders in DSM-5 and ICD-11: a conceptual framework. 61
26382166 2015
43
Between DSM and ICD: Paraphilias and the Transformation of Sexual Norms. 61
25933671 2015
44
The puzzle of intrafamilial child sexual abuse: a meta-analysis comparing intrafamilial and extrafamilial offenders with child victims. 61
25935749 2015
45
Heteronormativity and Repronormativity in Sexological "Perversion Theory" and the DSM-5's "Paraphilic Disorder" Diagnoses. 61
25894646 2015
46
The Role of Sexual Images in Online and Offline Sexual Behaviour With Minors. 61
25894354 2015
47
Psychological Treatment of the Paraphilias: a Review and an Appraisal of Effectiveness. 61
25903481 2015
48
Paraphilias and paraphilic disorders in Parkinson's disease: A systematic review of the literature. 61
25759330 2015
49
Visual Reaction Time™ as a predictor of sexual offense recidivism. 61
24058094 2015
50
Categories that should be removed from mental disorders classifications: perspectives and rationales of clinicians from eight countries. 61
25534610 2015

Variations for Paraphilia Disorder

Expression for Paraphilia Disorder

Search GEO for disease gene expression data for Paraphilia Disorder.

Pathways for Paraphilia Disorder

GO Terms for Paraphilia Disorder

Biological processes related to Paraphilia Disorder according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to cocaine GO:0042220 9.59 OXT DRD2
2 regulation of heart rate GO:0002027 9.58 OXT DRD2
3 negative regulation of blood pressure GO:0045776 9.58 OXT DRD2
4 arachidonic acid secretion GO:0050482 9.57 DRD4 DRD2
5 negative regulation of protein secretion GO:0050709 9.56 DRD4 DRD2
6 dopamine receptor signaling pathway GO:0007212 9.55 DRD4 DRD2
7 dopamine metabolic process GO:0042417 9.54 DRD4 DRD2
8 behavioral response to cocaine GO:0048148 9.52 DRD4 DRD2
9 positive regulation of renal sodium excretion GO:0035815 9.51 OXT DRD2
10 grooming behavior GO:0007625 9.49 OXT DRD2
11 synaptic transmission, dopaminergic GO:0001963 9.48 DRD4 DRD2
12 negative regulation of voltage-gated calcium channel activity GO:1901386 9.46 DRD4 DRD2
13 behavioral response to ethanol GO:0048149 9.43 DRD4 DRD2
14 drinking behavior GO:0042756 9.4 OXT DRD2
15 sperm ejaculation GO:0042713 9.37 SLC6A4 OXT
16 social behavior GO:0035176 9.33 SLC6A4 OXT DRD4
17 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.32 DRD4 DRD2
18 response to histamine GO:0034776 9.26 DRD4 DRD2
19 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 8.96 DRD4 DRD2
20 response to amphetamine GO:0001975 8.8 OXT DRD4 DRD2

Molecular functions related to Paraphilia Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium channel regulator activity GO:0015459 9.26 DRD4 DRD2
2 dopamine binding GO:0035240 9.16 DRD4 DRD2
3 dopamine neurotransmitter receptor activity GO:0004952 8.96 DRD4 DRD2
4 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 8.62 DRD4 DRD2

Sources for Paraphilia Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....