MCID: PRP015
MIFTS: 32

Paraphilia Disorder

Categories: Mental diseases

Aliases & Classifications for Paraphilia Disorder

MalaCards integrated aliases for Paraphilia Disorder:

Name: Paraphilia Disorder 12 15
Paraphilias 74
Paraphilia 77

Classifications:



External Ids:

Disease Ontology 12 DOID:0060044
UMLS 74 C0030482

Summaries for Paraphilia Disorder

Disease Ontology : 12 A sexual disorder that is characterized recurrent, intense sexually arousing fantasies, sexual urges or behaviors generally involving nonhuman objects.

MalaCards based summary : Paraphilia Disorder, also known as paraphilias, is related to social phobia and sexual disorder. An important gene associated with Paraphilia Disorder is SHOC2 (SHOC2 Leucine Rich Repeat Scaffold Protein), and among its related pathways/superpathways are Histidine metabolism and Osteoclast Signaling. Affiliated tissues include brain and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 77 Paraphilia (previously known as sexual perversion and sexual deviation) is the experience of intense... more...

Related Diseases for Paraphilia Disorder

Diseases related to Paraphilia Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 social phobia 30.4 MAOA PRL
2 sexual disorder 29.8 OXT PRL
3 fetishism 29.6 KHDRBS3 OXT RFX6
4 obsessive-compulsive disorder 29.5 MAOA OXT PRL
5 transvestism 29.4 KHDRBS3 OXT RFX6
6 disease of mental health 29.2 GRN MAOA OXT RTN4
7 exhibitionism 29.0 ABCB6 ADD2 MAOA MAOB PNP SHOC2
8 pedophilia 28.1 GRN IFNB1 IRGC LPP OXT PNP
9 bestiality 11.5
10 kleptomania 10.3 ABCB6 MAOA
11 atypical depressive disorder 10.3 MAOA MAOB
12 pathological gambling 10.3 MAOA MAOB
13 stereotypic movement disorder 10.3 ABCB6 PRL
14 trichotillomania 10.2 ABCB6 PRL
15 dystonia 1, torsion, autosomal dominant 10.2 MAOA MAOB
16 brunner syndrome 10.2 MAOA MAOB
17 androgenic alopecia 10.2 LPP PRL
18 sexual sadism 10.1
19 dependent personality disorder 10.1 MAOA MAOB TNFSF11
20 pure autonomic failure 10.1 MAOA MAOB
21 attention deficit-hyperactivity disorder 10.1
22 schizophrenia 10.1
23 pol iii-related leukodystrophies 10.1
24 antisocial personality disorder 10.0 MAOA MAOB
25 immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia 10.0 IFNB1 IRGC
26 hemometra 10.0 OXT PNP
27 echolalia 9.9 ADD2 GRN IRGC
28 breast abscess 9.9 IFNB1 OXT
29 alcohol dependence 9.9
30 osteoporosis 9.9
31 parkinson disease, late-onset 9.9
32 transsexuality 9.9
33 anorexia nervosa 9.9
34 voyeurism 9.9
35 obsessive-compulsive personality disorder 9.9
36 impulse control disorder 9.9
37 intermittent explosive disorder 9.9
38 hypoactive sexual desire disorder 9.9
39 avoidant personality disorder 9.9
40 personality disorder 9.9
41 dwarfism 9.9
42 depression 9.9
43 serotonin syndrome 9.8 MAOA MAOB OXT
44 premenstrual tension 9.8 OXT PRL
45 postpartum depression 9.8 MAOA OXT PRL
46 multiple personality disorder 9.7 IRGC OXT TNFSF11
47 specific developmental disorder 9.7 GRN OXT RTN4
48 separation anxiety disorder 9.6 OXT PRL RTN4
49 major depressive disorder 9.4 MAOA OXT PRL

Graphical network of the top 20 diseases related to Paraphilia Disorder:



Diseases related to Paraphilia Disorder

Symptoms & Phenotypes for Paraphilia Disorder

MGI Mouse Phenotypes related to Paraphilia Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.61 ADD2 GRN KHDRBS3 MAOA MAOB OXT
2 homeostasis/metabolism MP:0005376 9.4 ABCB6 ADD2 GRN IFNB1 LPP MAOA

Drugs & Therapeutics for Paraphilia Disorder

Search Clinical Trials , NIH Clinical Center for Paraphilia Disorder

Genetic Tests for Paraphilia Disorder

Anatomical Context for Paraphilia Disorder

MalaCards organs/tissues related to Paraphilia Disorder:

42
Brain, Bone

Publications for Paraphilia Disorder

Articles related to Paraphilia Disorder:

(show top 50) (show all 106)
# Title Authors Year
1
DSM-5, Paraphilias, and the Paraphilic Disorders: Confusion Reigns. ( 30790206 )
2019
2
Sex on the Silver Screen: Using Film to Teach About Paraphilias. ( 28685351 )
2018
3
Paraphilias and the ICD-11: Progress but Still Logically Inconsistent. ( 29294228 )
2018
4
Diagnostic Issues in the Paraphilias. ( 30032364 )
2018
5
Fanon and the New Paraphilias: Towards a Trans of Color Critique of the DSM-V. ( 30076507 )
2018
6
Paraphilias in the DSM-5. ( 26772210 )
2016
7
Single-victim and serial sexual homicide offenders: differences in crime, paraphilias and personality traits. ( 25111158 )
2015
8
Paraphilias and paraphilic disorders in Parkinson's disease: A systematic review of the literature. ( 25759330 )
2015
9
Psychological Treatment of the Paraphilias: a Review and an Appraisal of Effectiveness. ( 25903481 )
2015
10
Between DSM and ICD: Paraphilias and the Transformation of Sexual Norms. ( 25933671 )
2015
11
Paraphilias. ( 26382165 )
2015
12
Kinky parents and child custody: the effect of the DSM-5 differentiation between the paraphilias and paraphilic disorders. ( 24473942 )
2014
13
Assessment of the paraphilias. ( 24877702 )
2014
14
Pharmacologic treatment of paraphilias. ( 24877704 )
2014
15
The natural history of the paraphilias. ( 24877711 )
2014
16
Controversies in the diagnosis and treatment of paraphilias. ( 23152966 )
2013
17
Problems with paraphilias in the DSM-5. ( 23881707 )
2013
18
Paraphilias: definition, diagnosis and treatment. ( 24049640 )
2013
19
Philosophical issues in the paraphilias. ( 24060913 )
2013
20
Dopaminergic-induced paraphilias associated with impulse control and related disorders in patients with Parkinson disease. ( 23096066 )
2012
21
Pragmatic and Darwinian views of the paraphilias. ( 22124749 )
2012
22
Cognitive-behavioral treatment of the paraphilias. ( 23585466 )
2012
23
Pharmacological treatment of paraphilias. ( 23585467 )
2012
24
The use of online methodologies in studying paraphilias - A review. ( 26165601 )
2012
25
How unusual are the contents of paraphilias? Paraphilia-associated sexual arousal patterns in a community-based sample of men. ( 19929918 )
2011
26
Why are the paraphilias mental disorders? ( 21044271 )
2011
27
Proposals to add new paraphilias to the Diagnostic and Statistical Manual, Edition 5 (DSM-5). ( 21389175 )
2011
28
A brief history of field trials of the DSM diagnostic criteria for paraphilias. ( 21491137 )
2011
29
Current concepts in the pharmacotherapy of paraphilias. ( 21504253 )
2011
30
DSM-5 proposed diagnostic criteria for sexual paraphilias: tensions between diagnostic validity and forensic utility. ( 21531463 )
2011
31
Sampling Extreme Groups Invalidates Research on the Paraphilias: Implications for DSM-5 and Sex Offender Risk Assessments. ( 21796673 )
2011
32
Emotion and Morality in Psychopathy and Paraphilias. ( 24899928 )
2011
33
Disinhibition and narrative in the paraphilias. ( 20067815 )
2010
34
Paraphilias and sexual offences in the Bible. ( 20129434 )
2010
35
Paraphilias across cultures: contexts and controversies. ( 20358463 )
2010
36
Paraphilias in schizophrenia: differential diagnosis and treatment with selective serotonin reuptake inhibitors. ( 20403404 )
2010
37
Paraphilias with co-morbid psychopathy: the clinical and legal significance to sex offender assessments. ( 20422646 )
2010
38
Paraphilias in adult psychiatric inpatients. ( 20445840 )
2010
39
WFSBP treatment guidelines for the biological treatment of paraphilias. ( 20459369 )
2010
40
The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of paraphilias. ( 20459370 )
2010
41
DSM-5 proposals for paraphilias: suggestions for reducing false positives related to use of behavioral manifestations. ( 20697936 )
2010
42
References to the paraphilias and sexual crimes in the Bible. ( 19239958 )
2009
43
The treatment of paraphilias: an historical perspective. ( 18383202 )
2008
44
Issues for DSM-V: unintended consequences of small changes: the case of paraphilias. ( 18829878 )
2008
45
Evidence of primary, secondary, and collateral paraphilias left at serial murder and sex offender crime scenes. ( 17681002 )
2007
46
Mania associated with multiple paraphilias. ( 16444087 )
2006
47
The influence of brain abnormalities on psychosocial development, criminal history and paraphilias in sexual murderers. ( 16225232 )
2005
48
Osteoporosis associated with the treatment of paraphilias: a clinical review of seven case reports. ( 12877306 )
2003
49
Pharmacotherapy of paraphilias with long-acting agonists of luteinizing hormone-releasing hormone: a systematic review. ( 12927003 )
2003
50
Differential pharmacological treatment of paraphilias and sex offenders. ( 12971182 )
2003

Variations for Paraphilia Disorder

Expression for Paraphilia Disorder

Search GEO for disease gene expression data for Paraphilia Disorder.

Pathways for Paraphilia Disorder

Pathways related to Paraphilia Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.85 MAOA MAOB
2 10.46 IFNB1 TNFSF11
3
Show member pathways
10.33 MAOA MAOB
4 10.1 MAOA MAOB
5
Show member pathways
9.74 MAOA MAOB

GO Terms for Paraphilia Disorder

Cellular components related to Paraphilia Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial outer membrane GO:0005741 9.13 ABCB6 MAOA MAOB
2 mitochondrial envelope GO:0005740 8.62 ABCB6 MAOB

Biological processes related to Paraphilia Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to steroid hormone GO:0048545 9.26 MAOB OXT
2 neurotransmitter catabolic process GO:0042135 9.16 MAOA MAOB
3 regulation of signaling receptor activity GO:0010469 9.02 GRN IFNB1 OXT PRL TNFSF11
4 dopamine catabolic process GO:0042420 8.96 MAOA MAOB

Molecular functions related to Paraphilia Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 GRN IFNB1 TNFSF11
2 primary amine oxidase activity GO:0008131 8.62 MAOA MAOB

Sources for Paraphilia Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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