MCID: PRP015
MIFTS: 23

Paraphilia Disorder

Categories: Mental diseases

Aliases & Classifications for Paraphilia Disorder

MalaCards integrated aliases for Paraphilia Disorder:

Name: Paraphilia Disorder 12 15
Paraphilias 73
Paraphilia 76

Classifications:



External Ids:

Disease Ontology 12 DOID:0060044
UMLS 73 C0030482

Summaries for Paraphilia Disorder

MalaCards based summary : Paraphilia Disorder, also known as paraphilias, is related to social phobia and voyeurism. An important gene associated with Paraphilia Disorder is SHOC2 (SHOC2, Leucine Rich Repeat Scaffold Protein), and among its related pathways/superpathways are Osteoclast Signaling and Glycine, serine and threonine metabolism. Related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Paraphilia (previously known as sexual perversion and sexual deviation) is the experience of intense... more...

Related Diseases for Paraphilia Disorder

Diseases related to Paraphilia Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 social phobia 30.0 MAOA PRL
2 voyeurism 29.6 CBS SLC4A4 SLC4A8
3 obsessive-compulsive disorder 29.3 MAOA OXT PRL
4 fetishism 27.6 CBS KHDRBS3 OXT RFX6 SLC4A4 SLC4A8
5 transvestism 27.4 CBS KHDRBS3 OXT RFX6 SLC4A4 SLC4A8
6 exhibitionism 26.3 ABCB6 ADD2 CBS MAOA MAOB PNP
7 pedophilia 25.9 GOLGB1 GRN IFNB1 IRGC LPP OXT
8 bestiality 11.0
9 atypical depressive disorder 10.6 MAOA MAOB
10 gait apraxia 10.5 CBS GRN
11 stereotypic movement disorder 10.5 ABCB6 PRL
12 trichotillomania 10.3 ABCB6 PRL
13 kleptomania 10.3 ABCB6 MAOA
14 dementia, lewy body 10.2 CBS GRN MAOB
15 central nervous system disease 10.1 GRN IFNB1 MAOB
16 serotonin syndrome 10.0 MAOA MAOB OXT
17 nervous system disease 10.0 GRN IFNB1 MAOB
18 pathological gambling 10.0 MAOA MAOB
19 sexual sadism 9.9
20 multiple personality disorder 9.8 IRGC OXT TNFSF11
21 transsexuality 9.8
22 anorexia nervosa 9.8
23 transsexualism 9.8
24 obsessive-compulsive personality disorder 9.8
25 impulse control disorder 9.8
26 intermittent explosive disorder 9.8
27 hypoactive sexual desire disorder 9.8
28 avoidant personality disorder 9.8
29 personality disorder 9.8
30 dwarfism 9.8
31 ideomotor apraxia 9.7 CBS GRN RTN4
32 echolalia 9.7 ADD2 CBS GRN IRGC
33 mental depression 9.4 MAOA OXT RTN4
34 dependent personality disorder 9.4 MAOA MAOB RTN4 TNFSF11
35 specific developmental disorder 9.3 GRN OXT RTN4
36 separation anxiety disorder 9.3 OXT PRL RTN4
37 disease of mental health 9.2 GRN MAOA OXT RTN4

Graphical network of the top 20 diseases related to Paraphilia Disorder:



Diseases related to Paraphilia Disorder

Symptoms & Phenotypes for Paraphilia Disorder

GenomeRNAi Phenotypes related to Paraphilia Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 10.02 MAOA
2 Decreased viability GR00381-A-1 10.02 PNP RTN4
3 Decreased viability GR00402-S-2 10.02 CBS GOLGB1 GRN IFNB1 IRGC KHDRBS3
4 no effect GR00402-S-1 9.62 ABCB6 ADD2 CBS GOLGB1 GRN IFNB1

MGI Mouse Phenotypes related to Paraphilia Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 RFX6 TNFSF11 ADD2 GOLGB1 GRN KHDRBS3
2 homeostasis/metabolism MP:0005376 9.47 ABCB6 ADD2 GRN IFNB1 LPP MAOA

Drugs & Therapeutics for Paraphilia Disorder

Search Clinical Trials , NIH Clinical Center for Paraphilia Disorder

Genetic Tests for Paraphilia Disorder

Anatomical Context for Paraphilia Disorder

Publications for Paraphilia Disorder

Variations for Paraphilia Disorder

Expression for Paraphilia Disorder

Search GEO for disease gene expression data for Paraphilia Disorder.

Pathways for Paraphilia Disorder

GO Terms for Paraphilia Disorder

Cellular components related to Paraphilia Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial envelope GO:0005740 8.62 ABCB6 MAOB

Biological processes related to Paraphilia Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.35 GRN IFNB1 OXT PRL TNFSF11
2 neurotransmitter catabolic process GO:0042135 9.16 MAOA MAOB
3 dopamine catabolic process GO:0042420 8.62 MAOA MAOB

Molecular functions related to Paraphilia Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anion transmembrane transporter activity GO:0008509 9.16 SLC4A4 SLC4A8
2 sodium:bicarbonate symporter activity GO:0008510 8.96 SLC4A4 SLC4A8
3 primary amine oxidase activity GO:0008131 8.62 MAOA MAOB

Sources for Paraphilia Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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