MCID: PRP013
MIFTS: 26

Paraphimosis

Categories: Reproductive diseases

Aliases & Classifications for Paraphimosis

MalaCards integrated aliases for Paraphimosis:

Name: Paraphimosis 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5334
ICD10 33 N47.2
MeSH 44 D010263
NCIt 50 C34893
SNOMED-CT 68 13758004
UMLS 73 C0030483

Summaries for Paraphimosis

MalaCards based summary : Paraphimosis is related to priapism and fanconi-like syndrome. An important gene associated with Paraphimosis is NUDT1 (Nudix Hydrolase 1), and among its related pathways/superpathways is B Cell Development Pathways. The drugs Ketorolac and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include t cells and pancreas.

Wikipedia : 76 Paraphimosis is an uncommon medical condition in which the foreskin of a penis becomes trapped behind... more...

Related Diseases for Paraphimosis

Diseases related to Paraphimosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 priapism 10.2
2 fanconi-like syndrome 10.1 SLC5A2 SLC5A4
3 alacrima, achalasia, and mental retardation syndrome 10.0
4 hemangioma 10.0
5 impotence 10.0
6 phimosis 10.0
7 lichen sclerosus 10.0
8 ovarian solid teratoma 10.0 CD34 TNFRSF8
9 anal spasm 10.0 CAMP KANTR
10 sternum cancer 10.0 CD34 TNFRSF8
11 hordeolum 10.0 CD34 TNFRSF8
12 conventional fibrosarcoma 10.0 CD34 TNFRSF8
13 oculomotor nerve paralysis 10.0 CAMP KANTR
14 third cranial nerve disease 10.0 CAMP KANTR
15 anismus 10.0 CAMP KANTR
16 reticulohistiocytic granuloma 10.0 CD34 TNFRSF8
17 senile ectropion 10.0 KANTR SRCIN1
18 dystonia 1, torsion, autosomal dominant 9.9 CAMP KANTR
19 mechanical ectropion 9.9 CD34 KANTR
20 hemidystonia 9.9 CAMP KANTR
21 pediatric lymphoma 9.9 CD34 TNFRSF8
22 pancreas disease 9.9 DPP4 SLC5A2 SLC5A4
23 glucose metabolism disease 9.9 DPP4 SLC5A2 SLC5A4
24 acquired metabolic disease 9.9 DPP4 SLC5A2 SLC5A4
25 premenstrual tension 9.9 CAMP KANTR
26 maturity-onset diabetes of the young, type 1 9.9 DPP4 SLC5A2 SLC5A4
27 cardiovascular organ benign neoplasm 9.9 CD34 KANTR
28 benign perivascular tumor 9.9 CD34 KANTR
29 punctate epithelial keratoconjunctivitis 9.9 KANTR SRCIN1
30 lymphedema, hereditary, ii 9.9 CAMP KANTR
31 leukocyte disease 9.8 CD34 TNFRSF8
32 balanoposthitis 9.8 DPP4 SLC5A2 SLC5A4 SRCIN1
33 ecthyma 9.8 KANTR TNFRSF8
34 sezary's disease 9.8 DPP4 TNFRSF8

Graphical network of the top 20 diseases related to Paraphimosis:



Diseases related to Paraphimosis

Symptoms & Phenotypes for Paraphimosis

Drugs & Therapeutics for Paraphimosis

Drugs for Paraphimosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 1 66635-83-4, 74103-06-3 3826
2
Bupivacaine Approved, Investigational Phase 1 2180-92-9, 38396-39-3 2474
3
Acetaminophen Approved Phase 1 103-90-2 1983
4
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
5
Ibuprofen Approved Phase 1 15687-27-1 3672
6 Ketorolac Tromethamine Phase 1
7 Central Nervous System Depressants Phase 1
8 Peripheral Nervous System Agents Phase 1
9 Anti-Inflammatory Agents Phase 1
10 Cyclooxygenase Inhibitors Phase 1
11 Anti-Inflammatory Agents, Non-Steroidal Phase 1
12 Antipyretics Phase 1
13 Anesthetics Phase 1
14 Anesthetics, Inhalation Phase 1
15 Anesthetics, Local Phase 1
16 Analgesics Phase 1
17 Platelet Aggregation Inhibitors Phase 1
18 Anesthetics, General Phase 1
19 Antirheumatic Agents Phase 1
20 Analgesics, Non-Narcotic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Completed NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac

Search NIH Clinical Center for Paraphimosis

Cochrane evidence based reviews: paraphimosis

Genetic Tests for Paraphimosis

Anatomical Context for Paraphimosis

MalaCards organs/tissues related to Paraphimosis:

41
T Cells, Pancreas

Publications for Paraphimosis

Articles related to Paraphimosis:

(show top 50) (show all 80)
# Title Authors Year
1
Glans penis necrosis following paraphimosis: A rare case with brief literature review. ( 29181301 )
2018
2
Balanopreputial Adhesion and Paraphimosis due to Lichen Sclerosus. ( 29853765 )
2018
3
Paraphimosis ( 29083645 )
2017
4
Comparison of outcomes for pediatric paraphimosis reduction using topical anesthetic versus intravenous procedural sedation. ( 28416265 )
2017
5
Paediatric paraphimosis. ( 26781045 )
2016
6
S. Salim, A. Taylor & C. Carter. Female paraphimosis? Management of a large female urethral caruncle, trialling manual reduction. 2014. Journal of Obstetrics and Gynaecology; Early Online: 1-2. ( 25671780 )
2015
7
Female paraphimosis? Management of a large female urethral caruncle, trialling manual reduction. ( 24484437 )
2014
8
Ultrasound-guided dorsal penile nerve block for ED paraphimosis reduction. ( 25605058 )
2014
9
Reduction of paraphimosis in children: the EMLAAr glove technique. ( 24780686 )
2014
10
Combined preputial advancement and phallopexy as a revision technique for treating paraphimosis in a dog. ( 25348145 )
2014
11
Videos in clinical medicine. Reduction of paraphimosis in boys. ( 23534582 )
2013
12
Simple method of paraphimosis reduction revisited: point of technique and review of the literature. ( 22827972 )
2013
13
Mannitol for paraphimosis reduction. ( 23257575 )
2013
14
Treating equine paraphimosis. ( 23508857 )
2012
15
Primary cutaneous CD30+ T-cell lymphoproliferative disorder presenting as paraphimosis: a case report and review of the literature. ( 21810388 )
2011
16
Prepuce: phimosis, paraphimosis, and circumcision. ( 21298220 )
2011
17
Theriogenology question of the month. Trauma-induced paraphimosis. ( 21235366 )
2011
18
Coital paraphimosis causing penile necrosis. ( 21687264 )
2009
19
Penile hygiene: puberty, paraphimosis and personal care for men and boys with an intellectual disability. ( 19054270 )
2009
20
Paraphimosis leading to Fournier's Gangrene. ( 19268028 )
2009
21
Coital paraphimosis causing penile necrosis. ( 18573970 )
2008
22
Paraphimosis revisited: is chronic paraphimosis a predominantly third world condition? ( 18302866 )
2008
23
An unusual cause of paraphimosis: hemangioma of the glans penis. ( 18280267 )
2008
24
A key cause of paraphimosis. ( 16502063 )
2006
25
Paraphimosis. ( 16878846 )
2006
26
Treatment options for paraphimosis. ( 15857356 )
2005
27
Paraphimosis and amputation in a Nile crocodile (Crocodylus niloticus). ( 17312729 )
2005
28
Coital penile trauma with severe paraphimosis. ( 15649211 )
2005
29
Best evidence topic reports. Ice, pins, or sugar to reduce paraphimosis. ( 14734388 )
2004
30
Paraphimosis in a middle-aged adult after intercourse. ( 14989568 )
2004
31
Paraphimosis/priapism in rabbits. ( 12622297 )
2003
32
Phallopexy for treatment of paraphimosis in the dog. ( 11450842 )
2001
33
Reduction of paraphimosis the simple way--the Dundee technique. ( 11488759 )
2001
34
Case report. Paraphimosis due to erotic dancing. ( 11169281 )
2000
35
Paraphimosis: current treatment options. ( 11142469 )
2000
36
Reduction of paraphimosis with granulated sugar. ( 10375281 )
1999
37
Reduction of paraphimosis the simple way--the Dundee technique. ( 10610253 )
1999
38
Dorsal band traction for reduction of paraphimosis. ( 10565759 )
1999
39
Theriogenology question of the month. Priapism or paraphimosis. ( 10340072 )
1999
40
Reduction of paraphimosis the simple way - the Dundee technique. ( 10368214 )
1999
41
Reduction of paraphimosis with granulated sugar. ( 9839597 )
1998
42
Emergency treatment of paraphimosis. ( 9640518 )
1998
43
Reduction of paraphimosis with hyaluronidase. ( 9218042 )
1997
44
Non-painful paraphimosis causing partial amputation. ( 9439421 )
1997
45
Picture of the month. Paraphimosis. ( 9080944 )
1997
46
Reduction of paraphimosis: a technique based on pathophysiology. ( 8983618 )
1996
47
An unusual (and somewhat piercing) cause of paraphimosis. ( 8976792 )
1996
48
Reduction of paraphimosis with hyaluronidase. ( 8804504 )
1996
49
Paraphimosis in elderly men. ( 7755835 )
1995
50
"Puncture" technique for treating paraphimosis. ( 8029110 )
1994

Variations for Paraphimosis

Expression for Paraphimosis

Search GEO for disease gene expression data for Paraphimosis.

Pathways for Paraphimosis

Pathways related to Paraphimosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.35 CD34 TNFRSF8

GO Terms for Paraphimosis

Biological processes related to Paraphimosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose transmembrane transport GO:1904659 8.62 SLC5A2 SLC5A4

Molecular functions related to Paraphimosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose:sodium symporter activity GO:0005412 8.62 SLC5A2 SLC5A4

Sources for Paraphimosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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