MCID: PRP013
MIFTS: 29

Paraphimosis

Categories: Reproductive diseases

Aliases & Classifications for Paraphimosis

MalaCards integrated aliases for Paraphimosis:

Name: Paraphimosis 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5334
ICD10 33 N47.2
MeSH 44 D010263
NCIt 50 C34893
SNOMED-CT 68 13758004 155922002
UMLS 73 C0030483

Summaries for Paraphimosis

MalaCards based summary : Paraphimosis is related to chronic dacryocystitis and chronic inflammation of lacrimal passage. An important gene associated with Paraphimosis is NPPC (Natriuretic Peptide C), and among its related pathways/superpathways are Androgen receptor signaling pathway and B Cell Development Pathways. The drugs Sevoflurane and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include t cells.

Wikipedia : 76 Paraphimosis is an uncommon medical condition in which the foreskin of a penis becomes trapped behind... more...

Related Diseases for Paraphimosis

Diseases related to Paraphimosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 chronic dacryocystitis 10.3 FLNA SRCIN1
2 chronic inflammation of lacrimal passage 10.3 FLNA SRCIN1
3 urethral calculus 10.3 FLNA KLK3
4 lichen nitidus 10.1 FLNA TNFRSF8
5 skeletal dysplasias 10.0 FLNA NPPC
6 exophthalmos 10.0 CD34 FLNA
7 ovarian solid teratoma 10.0 CD34 TNFRSF8
8 sternum cancer 10.0 CD34 TNFRSF8
9 conventional fibrosarcoma 10.0 CD34 TNFRSF8
10 anal spasm 10.0 CAMP KANTR
11 urethritis 10.0
12 priapism 10.0
13 oculomotor nerve paralysis 9.9 CAMP KANTR
14 third cranial nerve disease 9.9 CAMP KANTR
15 anismus 9.9 CAMP KANTR
16 senile entropion 9.9 FLNA KANTR
17 leech infestation 9.9 FLNA KANTR
18 reticulohistiocytic granuloma 9.9 CD34 TNFRSF8
19 cranio-facial dystonia 9.9 CAMP KANTR
20 subdural empyema 9.8 FLNA KANTR
21 lymphedema, hereditary, ii 9.8 CAMP KANTR
22 mechanical ectropion 9.8 CD34 KANTR
23 aging 9.8
24 alacrima, achalasia, and mental retardation syndrome 9.8
25 autoimmune lymphoproliferative syndrome, type v 9.8
26 hemangioma 9.8
27 impotence 9.8
28 phimosis 9.8
29 pseudohermaphroditism 9.8
30 lichen sclerosus 9.8
31 dystonia 1, torsion, autosomal dominant 9.8 CAMP KANTR
32 hemidystonia 9.8 CAMP KANTR
33 premenstrual tension 9.8 CAMP KANTR
34 rectal disease 9.7 KANTR KLK3
35 pediatric lymphoma 9.7 CD34 TNFRSF8
36 radiation cystitis 9.7 KANTR KLK3
37 punctate epithelial keratoconjunctivitis 9.6 KANTR SRCIN1
38 cell type cancer 9.6 CD34 KLK3
39 cardiovascular organ benign neoplasm 9.3 CD34 FLNA KANTR
40 benign perivascular tumor 9.3 CD34 FLNA KANTR
41 glomangioma 9.3 CD34 FLNA KANTR
42 ecthyma 9.3 KANTR TNFRSF8
43 west syndrome 9.1 FLNA KANTR

Graphical network of the top 20 diseases related to Paraphimosis:



Diseases related to Paraphimosis

Symptoms & Phenotypes for Paraphimosis

Drugs & Therapeutics for Paraphimosis

Drugs for Paraphimosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
2
Bupivacaine Approved, Investigational Phase 1 2180-92-9, 38396-39-3 2474
3
Ketorolac Approved Phase 1 74103-06-3, 66635-83-4 3826
4
Acetaminophen Approved Phase 1 103-90-2 1983
5
Ibuprofen Approved Phase 1 15687-27-1 3672
6 Analgesics Phase 1
7 Central Nervous System Depressants Phase 1
8 Cyclooxygenase Inhibitors Phase 1
9 Analgesics, Non-Narcotic Phase 1
10 Anesthetics Phase 1
11 Anesthetics, General Phase 1
12 Anesthetics, Inhalation Phase 1
13 Anesthetics, Local Phase 1
14 Peripheral Nervous System Agents Phase 1
15 Platelet Aggregation Inhibitors Phase 1
16 Ketorolac Tromethamine Phase 1
17 Anti-Inflammatory Agents Phase 1
18 Antipyretics Phase 1
19 Anti-Inflammatory Agents, Non-Steroidal Phase 1
20 Antirheumatic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Completed NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac

Search NIH Clinical Center for Paraphimosis

Cochrane evidence based reviews: paraphimosis

Genetic Tests for Paraphimosis

Anatomical Context for Paraphimosis

MalaCards organs/tissues related to Paraphimosis:

41
T Cells

Publications for Paraphimosis

Articles related to Paraphimosis:

(show top 50) (show all 79)
# Title Authors Year
1
Glans penis necrosis following paraphimosis: A rare case with brief literature review. ( 29181301 )
2018
2
Balanopreputial Adhesion and Paraphimosis due to Lichen Sclerosus. ( 29853765 )
2018
3
Paraphimosis ( 29083645 )
2017
4
Comparison of outcomes for pediatric paraphimosis reduction using topical anesthetic versus intravenous procedural sedation. ( 28416265 )
2017
5
Paediatric paraphimosis. ( 26781045 )
2016
6
S. Salim, A. Taylor & C. Carter. Female paraphimosis? Management of a large female urethral caruncle, trialling manual reduction. 2014. Journal of Obstetrics and Gynaecology; Early Online: 1-2. ( 25671780 )
2015
7
Female paraphimosis? Management of a large female urethral caruncle, trialling manual reduction. ( 24484437 )
2014
8
Ultrasound-guided dorsal penile nerve block for ED paraphimosis reduction. ( 25605058 )
2014
9
Reduction of paraphimosis in children: the EMLAAr glove technique. ( 24780686 )
2014
10
Combined preputial advancement and phallopexy as a revision technique for treating paraphimosis in a dog. ( 25348145 )
2014
11
Videos in clinical medicine. Reduction of paraphimosis in boys. ( 23534582 )
2013
12
Simple method of paraphimosis reduction revisited: point of technique and review of the literature. ( 22827972 )
2013
13
Mannitol for paraphimosis reduction. ( 23257575 )
2013
14
Treating equine paraphimosis. ( 23508857 )
2012
15
Primary cutaneous CD30+ T-cell lymphoproliferative disorder presenting as paraphimosis: a case report and review of the literature. ( 21810388 )
2011
16
Prepuce: phimosis, paraphimosis, and circumcision. ( 21298220 )
2011
17
Theriogenology question of the month. Trauma-induced paraphimosis. ( 21235366 )
2011
18
Coital paraphimosis causing penile necrosis. ( 21687264 )
2009
19
Penile hygiene: puberty, paraphimosis and personal care for men and boys with an intellectual disability. ( 19054270 )
2009
20
Paraphimosis leading to Fournier's Gangrene. ( 19268028 )
2009
21
Coital paraphimosis causing penile necrosis. ( 18573970 )
2008
22
Paraphimosis revisited: is chronic paraphimosis a predominantly third world condition? ( 18302866 )
2008
23
An unusual cause of paraphimosis: hemangioma of the glans penis. ( 18280267 )
2008
24
A key cause of paraphimosis. ( 16502063 )
2006
25
Paraphimosis. ( 16878846 )
2006
26
Treatment options for paraphimosis. ( 15857356 )
2005
27
Paraphimosis and amputation in a Nile crocodile (Crocodylus niloticus). ( 17312729 )
2005
28
Coital penile trauma with severe paraphimosis. ( 15649211 )
2005
29
Best evidence topic reports. Ice, pins, or sugar to reduce paraphimosis. ( 14734388 )
2004
30
Paraphimosis in a middle-aged adult after intercourse. ( 14989568 )
2004
31
Paraphimosis/priapism in rabbits. ( 12622297 )
2003
32
Phallopexy for treatment of paraphimosis in the dog. ( 11450842 )
2001
33
Reduction of paraphimosis the simple way--the Dundee technique. ( 11488759 )
2001
34
Case report. Paraphimosis due to erotic dancing. ( 11169281 )
2000
35
Paraphimosis: current treatment options. ( 11142469 )
2000
36
Reduction of paraphimosis with granulated sugar. ( 10375281 )
1999
37
Reduction of paraphimosis the simple way--the Dundee technique. ( 10610253 )
1999
38
Dorsal band traction for reduction of paraphimosis. ( 10565759 )
1999
39
Theriogenology question of the month. Priapism or paraphimosis. ( 10340072 )
1999
40
Reduction of paraphimosis with granulated sugar. ( 9839597 )
1998
41
Emergency treatment of paraphimosis. ( 9640518 )
1998
42
Reduction of paraphimosis with hyaluronidase. ( 9218042 )
1997
43
Non-painful paraphimosis causing partial amputation. ( 9439421 )
1997
44
Picture of the month. Paraphimosis. ( 9080944 )
1997
45
Reduction of paraphimosis: a technique based on pathophysiology. ( 8983618 )
1996
46
An unusual (and somewhat piercing) cause of paraphimosis. ( 8976792 )
1996
47
Reduction of paraphimosis with hyaluronidase. ( 8804504 )
1996
48
Paraphimosis in elderly men. ( 7755835 )
1995
49
"Puncture" technique for treating paraphimosis. ( 8029110 )
1994
50
Emergency reduction of paraphimosis. ( 7748840 )
1994

Variations for Paraphimosis

Expression for Paraphimosis

Search GEO for disease gene expression data for Paraphimosis.

Pathways for Paraphimosis

Pathways related to Paraphimosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.91 FLNA KLK3
2 10.35 CD34 TNFRSF8

GO Terms for Paraphimosis

Cellular components related to Paraphimosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 CAMP CD34 FLNA KLK3 NPPC
2 secretory granule GO:0030141 8.96 KLK3 NPPC

Biological processes related to Paraphimosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell migration GO:0030334 8.62 FLNA SRCIN1

Sources for Paraphimosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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