MCID: PRP013
MIFTS: 28

Paraphimosis

Categories: Reproductive diseases

Aliases & Classifications for Paraphimosis

MalaCards integrated aliases for Paraphimosis:

Name: Paraphimosis 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5334
MeSH 44 D010263
NCIt 50 C34893
SNOMED-CT 67 155922002
ICD10 32 N47.2
UMLS 70 C0030483

Summaries for Paraphimosis

MalaCards based summary : Paraphimosis is related to phimosis and priapism. An important gene associated with Paraphimosis is NPR2 (Natriuretic Peptide Receptor 2), and among its related pathways/superpathways is cGMP-PKG signaling pathway. The drugs Acetaminophen and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia : 73 Paraphimosis is an uncommon medical condition in which the foreskin of a penis becomes trapped behind... more...

Related Diseases for Paraphimosis

Graphical network of the top 20 diseases related to Paraphimosis:



Diseases related to Paraphimosis

Symptoms & Phenotypes for Paraphimosis

Drugs & Therapeutics for Paraphimosis

Drugs for Paraphimosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 2 103-90-2 1983
2
Sevoflurane Approved, Vet_approved Phase 2 28523-86-6 5206
3
Ketorolac Approved Phase 2 74103-06-3, 66635-83-4 3826
4
Ibuprofen Approved Phase 2 15687-27-1 3672
5
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
6 Anesthetics Phase 2
7 Analgesics, Non-Narcotic Phase 2
8 Antirheumatic Agents Phase 2
9 Cyclooxygenase Inhibitors Phase 2
10 Anesthetics, General Phase 2
11 Analgesics Phase 2
12 Anti-Inflammatory Agents Phase 2
13 Anesthetics, Inhalation Phase 2
14 Anesthetics, Local Phase 2
15 Ketorolac Tromethamine Phase 2
16 Antipyretics Phase 2
17 Anti-Inflammatory Agents, Non-Steroidal Phase 2
18 Platelet Aggregation Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Control Trial Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Not yet recruiting NCT04646967 Phase 2 Bupivacain;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac
2 A Pilot Study Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Completed NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac

Search NIH Clinical Center for Paraphimosis

Cochrane evidence based reviews: paraphimosis

Genetic Tests for Paraphimosis

Anatomical Context for Paraphimosis

MalaCards organs/tissues related to Paraphimosis:

40
Skin

Publications for Paraphimosis

Articles related to Paraphimosis:

(show top 50) (show all 184)
# Title Authors PMID Year
1
Circumcision devices versus standard surgical techniques in adolescent and adult male circumcisions. 61
33786810 2021
2
Cosmetic results of circumcision and scar wrinkling: Do we exaggerate in terms of hemostasis and sutures? 61
33729060 2021
3
Managing complications associated with the use of indwelling urinary catheters. 61
33073550 2020
4
[Urologic Emergencies: Paraphimosis]. 61
32870094 2020
5
[Learning curve for inflatable penile prosthesis]. 61
31786111 2019
6
Double scrotum? A rare ignored paraphimosis - Case report. 61
31367524 2019
7
Long-term follow-up of penile glans necrosis due to paraphimosis. 61
32743402 2019
8
Adenovirus-associated paraphimosis. 61
31072279 2019
9
Comparative risk of genital infections associated with sodium-glucose co-transporter-2 inhibitors. 61
30207042 2019
10
Case Report: Penile necrosis associated to paraphimosis with calciphylaxis due to terminal chronic kidney disease. 61
31448110 2019
11
Penile Median Raphe Anomalies as an Indicator of Megameatus Intact Prepuce Anomaly in Children Undergoing Routine Circumcision. 61
30096348 2018
12
Acupuncture as a Nonpharmacologic Treatment for Pain in a Pediatric Emergency Department. 61
30247457 2018
13
Complications associated with intimate body piercings. 61
30261561 2018
14
Combined caudal-superficial-epigastric axial pattern flap and full-thickness buccal mucosa graft for single-stage preputial reconstruction in six dogs. 61
29665060 2018
15
Balanopreputial Adhesion and Paraphimosis due to Lichen Sclerosus. 61
29853765 2018
16
Urologic Emergencies. 61
29406065 2018
17
Glans penis necrosis following paraphimosis: A rare case with brief literature review. 61
29181301 2018
18
Comparison of outcomes for pediatric paraphimosis reduction using topical anesthetic versus intravenous procedural sedation. 61
28416265 2017
19
Diphallia in a Mixed-Breed Puppy: Case Report. 61
28792795 2017
20
Prevalence of preoperative penile abnormalities among voluntary male medical circumcision patients in Swaziland. 61
28088311 2017
21
Invasive Reduction of Paraphimosis in an Adolescent Male While in a Deployed Austere Environment. 61
28285474 2017
22
The clinical spectrum of syphilitic balanitis of Follmann: report of five cases and a review of the literature. 61
27421838 2016
23
Newborn Male Circumcision with Parental Consent, as Stated in the AAP Circumcision Policy Statement, Is Both Legal and Ethical. 61
27338601 2016
24
Syphilitic lymphadenitis clinically and histologically mimicking lymphogranuloma venereum. 61
27138664 2016
25
Paediatric paraphimosis. 61
26781045 2016
26
Charles Richard de Beauregard and the treatment of blennorrhagic urethral stenosis in Madrid in the 18th century: Advertising, secrecy and deception. 61
26142893 2015
27
Benign penile skin anomalies in children: a primer for pediatricians. 61
25754752 2015
28
Effect of two surgical circumcision procedures on postoperative pain: A prospective, randomized, double-blind study. 61
25842991 2015
29
Ultrasound-guided dorsal penile nerve block for ED paraphimosis reduction. 61
25605058 2015
30
S. Salim, A. Taylor & C. Carter. Female paraphimosis? Management of a large female urethral caruncle, trialling manual reduction. 2014. Journal of Obstetrics and Gynaecology; Early Online: 1-2. 61
25671780 2015
31
Introducing the Quill™ device for modified sleeve circumcision with subcutaneous suture: a retrospective study of 70 cases. 61
25677813 2015
32
[Urological emergencies in paediatric surgery: a survey of 40 cases]. 61
29927143 2015
33
Combined preputial advancement and phallopexy as a revision technique for treating paraphimosis in a dog. 61
25348145 2014
34
Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility. 61
25012822 2014
35
A guide to the management of urologic dilemmas for the primary care physician (PCP). 61
24978632 2014
36
Female paraphimosis? Management of a large female urethral caruncle, trialling manual reduction. 61
24484437 2014
37
Reduction of paraphimosis in children: the EMLA® glove technique. 61
24780686 2014
38
Pathological conditions associated with the male reproductive tract of the sahel bucks. 61
24790768 2014
39
A prospective analysis of consultation for difficult urinary catheter insertion at tertiary care centres in Northern Alberta. 61
24319514 2013
40
Emergency medicine procedural skills: what are residents missing? 61
23777999 2013
41
Circumcision: perspective in a Nigerian teaching hospital. 61
24192474 2013
42
Histopathological examination of the prepuce after circumcision: Is it a waste of resources? 61
23860069 2013
43
Videos in clinical medicine. Reduction of paraphimosis in boys. 61
23534582 2013
44
Simple method of paraphimosis reduction revisited: point of technique and review of the literature. 61
22827972 2013
45
Mannitol for paraphimosis reduction. 61
23257575 2013
46
Penile angioedema developing after 3 years of ACEI therapy. 61
22560272 2012
47
[Prepuce in boys and adolescents: what when, and how?]. 61
22924249 2012
48
[Trans-scrotal penile degloving, a new procedure for corporoplasties]. 61
22522461 2012
49
A new training model for adult circumcision. 61
22677579 2012
50
The advantages of using photographs and video images in telephone consultations with a specialist in paediatric surgery. 61
22878761 2012

Variations for Paraphimosis

Expression for Paraphimosis

Search GEO for disease gene expression data for Paraphimosis.

Pathways for Paraphimosis

Pathways related to Paraphimosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.3 PDE5A NPR2 NPPC

GO Terms for Paraphimosis

Biological processes related to Paraphimosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron projection development GO:0010976 9.51 ALKAL2 ALKAL1
2 ossification GO:0001503 9.49 NPR2 NPPC
3 regulation of cardiac conduction GO:1903779 9.48 NPR2 NPPC
4 positive regulation of protein tyrosine kinase activity GO:0061098 9.46 ALKAL2 ALKAL1
5 cGMP-mediated signaling GO:0019934 9.43 NPR2 NPPC
6 cGMP biosynthetic process GO:0006182 9.4 NPR2 NPPC
7 receptor guanylyl cyclase signaling pathway GO:0007168 9.37 NPR2 NPPC
8 reproductive process GO:0022414 9.32 NPR2 NPPC
9 positive regulation of cGMP-mediated signaling GO:0010753 9.26 NPR2 NPPC
10 negative regulation of meiotic cell cycle GO:0051447 9.16 NPR2 NPPC
11 negative regulation of oocyte maturation GO:1900194 8.96 NPR2 NPPC
12 positive regulation of ERK5 cascade GO:0070378 8.62 ALKAL2 ALKAL1

Molecular functions related to Paraphimosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 8.96 ALKAL2 ALKAL1
2 receptor signaling protein tyrosine kinase activator activity GO:0030298 8.62 ALKAL2 ALKAL1

Sources for Paraphimosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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