MCID: PRP005
MIFTS: 35

Parapsoriasis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Parapsoriasis

MalaCards integrated aliases for Parapsoriasis:

Name: Parapsoriasis 12 77 54 45 15 17 74
Parapsoriasis En Plaques 74
Parapsoriasis En Plaque 54
Digitate Dermatosis 54

Classifications:



External Ids:

Disease Ontology 12 DOID:9088
ICD9CM 36 696.2
MeSH 45 D010267
NCIt 51 C3312
SNOMED-CT 69 88233000
ICD10 34 L41 L41.9

Summaries for Parapsoriasis

NIH Rare Diseases : 54 Parapsoriasis describes a group of skin diseases that can be characterized by scaly patches or slightly elevated papules and/or plaques (red, scaly patches) that have a resemblance to psoriasis. However, this description includes several inflammatory cutaneous diseases that are unrelated with respect to pathogenesis, histopathology, and response to treatment. Because of the variation in clinical presentation and a lack of a specific diagnostic finding on histopathology, a uniformly accepted definition of parapsoriasis remains lacking. There are 2 general forms: a small plaque type, which is usually benign, and a large plaque type, which is a precursor of cutaneous T-cell lymphoma (CTCL). Treatment of small plaque parapsoriasis is unnecessary but can include emollients, topical tar preparations or corticosteroids, and/or phototherapy. Treatment of large plaque parapsoriasis is phototherapy or topical corticosteroids.

MalaCards based summary : Parapsoriasis, also known as parapsoriasis en plaques, is related to degos 'en cocarde' erythrokeratoderma and pityriasis lichenoides chronica. An important gene associated with Parapsoriasis is LUZP4 (Leucine Zipper Protein 4), and among its related pathways/superpathways is Amino Acid metabolism. The drugs Apremilast and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Parapsoriasis refers to one of a group of skin disorders that are characterized primarily by their... more...

Related Diseases for Parapsoriasis

Graphical network of the top 20 diseases related to Parapsoriasis:



Diseases related to Parapsoriasis

Symptoms & Phenotypes for Parapsoriasis

GenomeRNAi Phenotypes related to Parapsoriasis according to GeneCards Suite gene sharing:

27 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.47 LPP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.47 OAT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.47 OAT
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.47 LPP
5 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.47 OAT
6 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.47 LPP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.47 OAT
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 LPP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.47 LPP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.47 LPP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.47 LPP
12 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.47 LPP OAT
13 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.47 LPP

Drugs & Therapeutics for Parapsoriasis

Drugs for Parapsoriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
2 Angiogenesis Inhibitors Phase 4
3 Angiogenesis Modulating Agents Phase 4
4 Peripheral Nervous System Agents Phase 4
5 Anti-Bacterial Agents Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Anti-Infective Agents Phase 4
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9 Immunosuppressive Agents Phase 4
10 Immunologic Factors Phase 4
11 Analgesics Phase 4
12 Antirheumatic Agents Phase 4,Phase 3
13 Analgesics, Non-Narcotic Phase 4
14
Infliximab Approved Phase 3 170277-31-3
15 Gastrointestinal Agents Phase 3
16 Dermatologic Agents Phase 3
17
Bexarotene Approved, Investigational Phase 2 153559-49-0 82146
18
Azithromycin Approved Not Applicable 83905-01-5 55185 447043

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 4 Study of Efficacy and Safety of Apremilast in Subjects With Moderate Plaque Psoriasis. Completed NCT02425826 Phase 4 Apremilast;Placebo;Placebo-Apremilast
2 Natural Gels for Treatment of Plaque Psoriasis Completed NCT02330237 Phase 2, Phase 3 natural gels;Placebo
3 A Study of the Safety and Effectiveness of Infliximab in Patients With Plaque-type Psoriasis Completed NCT00106847 Phase 3 Infliximab
4 Phase II Trial to Evaluate the Efficacy of Topical Bexarotene Gel in Patients With Parapsoriasis Terminated NCT00322296 Phase 2 Bexarotene 1% gel
5 Phase 1 Study of CC-90005 in Healthy Subjects and Subjects With Moderate to Severe Plaque-type Psoriasis Terminated NCT02502188 Phase 1 CC-90005;Placebo
6 Pityriasis Lichenoides Chronica, Role of Streptococcal Infection and Azithromycin Not yet recruiting NCT03831269 Not Applicable Azithromycin

Search NIH Clinical Center for Parapsoriasis

Cochrane evidence based reviews: parapsoriasis

Genetic Tests for Parapsoriasis

Anatomical Context for Parapsoriasis

MalaCards organs/tissues related to Parapsoriasis:

42
Skin, T Cells, Testes

Publications for Parapsoriasis

Articles related to Parapsoriasis:

(show top 50) (show all 196)
# Title Authors Year
1
Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. ( 29795283 )
2018
2
Chlamydiales Bacterial Sequences in Lesional and Healthy Skin of Patients with Parapsoriasis. ( 29956717 )
2018
3
CD30-Positive Angioinvasive Lymphomatoid Papulosis (Type E) Developing from Parapsoriasis en Plaque. ( 30687061 )
2018
4
Risk of venous thromboembolism in patients with mycosis fungoides and parapsoriasis: A Danish nationwide population-based cohort study. ( 30521824 )
2018
5
Risk of venous thromboembolism in patients with mycosis fungoides and parapsoriasis: A Danish nationwide population-based cohort study. ( 29203438 )
2017
6
Skin Microbiome in Small- and Large-plaque Parapsoriasis. ( 28175925 )
2017
7
Systematic Review of Cases of Cutaneous T-Cell Lymphoma Transformation in Pityriasis Lichenoides and Small Plaque Parapsoriasis. ( 27031678 )
2016
8
Granulomatous slack skin - seven years follow-up of a case with features of "parapsoriasis en plaques", muscle involvement, granulomatous vasculitis, and necrobiotic changes. ( 27516031 )
2016
9
Risk of Acute Myocardial Infarction or Stroke in Patients with Mycosis Fungoides and Parapsoriasis. ( 26576854 )
2016
10
Subsequent cancers, mortality, and causes of death in patients with mycosis fungoides and parapsoriasis: a Danish nationwide, population-based cohort study. ( 24836079 )
2014
11
Efficacy of low-dose ultraviolet a-1 phototherapy for parapsoriasis/early-stage mycosis fungoides. ( 24502428 )
2014
12
Biopsying parapsoriasis: quo vadis? Are morphological stains enough or are ancillary tests needed? ( 25607389 )
2014
13
Ichthyosiform large plaque parapsoriasis: report of a rare entity. ( 24082186 )
2013
14
An evaluation of the treatment of parapsoriasis with phototherapy. ( 23739710 )
2013
15
Topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis. ( 22229501 )
2013
16
Predictive value of T-cell clone and CD13 antigen in parapsoriasis. ( 23859066 )
2013
17
Digitate dermatosis (small-plaque parapsoriasis). ( 23286793 )
2012
18
Hypopigmented parapsoriasis en plaque, a new, overlooked member of the parapsoriasis family: a report of 34 patients and a 7-year experience. ( 22459359 )
2012
19
[Parapsoriasis--to be or not be (mycosis fungoides)]. ( 23316666 )
2012
20
Retrospective study of 24 patients with large or small plaque parapsoriasis treated with ultraviolet B therapy. ( 21973175 )
2012
21
Trichophyton Schoenleinii-induced widespread tinea corporis mimicking parapsoriasis. ( 23518026 )
2012
22
Human herpesvirus 8 is not detectable in lesions of large plaque parapsoriasis, and in early-stage sporadic, familial, and juvenile cases of mycosis fungoides. ( 21704421 )
2012
23
The role of immunohistochemical analysis in the diagnosis of parapsoriasis. ( 20083298 )
2011
24
Large plaque parapsoriasis with the "deck-chair" sign successfully treated with bath psoralen and ultraviolet A therapy. ( 20536677 )
2010
25
The conundrum of parapsoriasis versus patch stage of mycosis fungoides. ( 19439874 )
2009
26
Parapsoriasis lichenoides/parapsoriasis variegata--a new concept. ( 21465693 )
2009
27
Evaluation of the role of human herpes virus 6 and 8 in parapsoriasis. ( 18803660 )
2009
28
Treatment of parapsoriasis with bexarotene 1% gel. ( 19126035 )
2008
29
A patient with clinicopathologic features of small plaque parapsoriasis presenting later with plaque-stage mycosis fungoides: report of a case and comparative retrospective study of 27 cases of "nonprogressive" small plaque parapsoriasis. ( 18694680 )
2008
30
High association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides. ( 18711073 )
2008
31
Anaplastic large cell lymphoma associated with parapsoriasis en plaques. ( 18480948 )
2008
32
I^I' T cells as potential contributors to the progression of parapsoriasis to mycosis fungoides. ( 21479436 )
2008
33
Immunohistochemical analysis of small plaque parapsoriasis: involvement of dendritic cells. ( 18258285 )
2008
34
Early-stage mycosis fungoides, parapsoriasis en plaque, and pregnancy. ( 17269968 )
2007
35
Parapsoriasis: a complex issue. ( 17975354 )
2007
36
Retroperitoneal liposarcoma associated with small plaque parapsoriasis. ( 17620118 )
2007
37
Expression of HECA-452 in parapsoriasis and mycosis fungoides. ( 16569348 )
2006
38
Analysis of p53 gene mutations in parapsoriasis. ( 16898923 )
2006
39
Excimer-laser (308 nm) treatment of large plaque parapsoriasis and long-term follow-up. ( 16613751 )
2006
40
Narrowband UVB phototherapy for small plaque parapsoriasis. ( 16684286 )
2006
41
Lymphoma with large-plaque parapsoriasis treated with PUVA. ( 16048755 )
2005
42
Treatment of small plaque parapsoriasis with narrow-band (311 nm) ultraviolet B: a retrospective study. ( 15953075 )
2005
43
A retrospective study of the probability of the evolution of parapsoriasis en plaques into mycosis fungoides. ( 16191852 )
2005
44
Analysis of T-cell receptor gamma gene rearrangements by PCR-Genescan and PCR-polyacrylamide gel electrophoresis in early-stage mycosis fungoides/large-plaque parapsoriasis. ( 14657643 )
2003
45
Psoriasis and parapsoriasis: since 200 and 100 years, respectively. ( 12705739 )
2003
46
Absence of Epstein-Barr virus and human herpesvirus-6 in pityriasis lichenoides and plaque parapsoriasis. ( 12428859 )
2002
47
Demonstration of characteristic skin surface contours of extramammary Paget's disease and parapsoriasis en plaque by image analysis of negative impression replicas. ( 12354416 )
2002
48
Clonal T cell receptor gamma-chain gene rearrangement by PCR-based GeneScan analysis in the skin and blood of patients with parapsoriasis and early-stage mycosis fungoides. ( 12115881 )
2002
49
Cytokine production profile of peripheral blood mononuclear cells in patients with large-plaque parapsoriasis. ( 11453828 )
2001
50
Shortened telomere length is demonstrated in T-cell subsets together with a pronounced increased telomerase activity in CD4 positive T cells from blood of patients with mycosis fungoides and parapsoriasis. ( 11589730 )
2001

Variations for Parapsoriasis

Expression for Parapsoriasis

Search GEO for disease gene expression data for Parapsoriasis.

Pathways for Parapsoriasis

Pathways related to Parapsoriasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.58 OAT TDO2

GO Terms for Parapsoriasis

Sources for Parapsoriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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