MCID: PRP005
MIFTS: 38

Parapsoriasis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Parapsoriasis

MalaCards integrated aliases for Parapsoriasis:

Name: Parapsoriasis 12 75 53 44 15 17 72 33
Parapsoriasis En Plaques 72
Parapsoriasis En Plaque 53
Digitate Dermatosis 53

Classifications:



External Ids:

Disease Ontology 12 DOID:9088
ICD9CM 35 696.2
MeSH 44 D010267
NCIt 50 C3312
SNOMED-CT 68 88233000
ICD10 33 L41 L41.9
UMLS 72 C0030491 C0162442

Summaries for Parapsoriasis

NIH Rare Diseases : 53 Parapsoriasis describes a group of skin diseases that can be characterized by scaly patches or slightly elevated papules and/or plaques (red, scaly patches) that have a resemblance to psoriasis. However, this description includes several inflammatory cutaneous diseases that are unrelated with respect to pathogenesis, histopathology, and response to treatment. Because of the variation in clinical presentation and a lack of a specific diagnostic finding on histopathology, a uniformly accepted definition of parapsoriasis remains lacking. There are 2 general forms: a small plaque type, which is usually benign, and a large plaque type, which is a precursor of cutaneous T-cell lymphoma (CTCL). Treatment of small plaque parapsoriasis is unnecessary but can include emollients, topical tar preparations or corticosteroids, and/or phototherapy. Treatment of large plaque parapsoriasis is phototherapy or topical corticosteroids.

MalaCards based summary : Parapsoriasis, also known as parapsoriasis en plaques, is related to pityriasis lichenoides chronica and mycosis fungoides. An important gene associated with Parapsoriasis is LUZP4 (Leucine Zipper Protein 4), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and IL12-mediated signaling events. The drugs Apremilast and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone.

Wikipedia : 75 Parapsoriasis refers to one of a group of skin disorders that are characterized primarily by their... more...

Related Diseases for Parapsoriasis

Diseases related to Parapsoriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 pityriasis lichenoides chronica 10.9
2 mycosis fungoides 10.9
3 lymphomatoid papulosis 10.9
4 pityriasis lichenoides et varioliformis acuta 10.9
5 pityriasis lichenoides 10.6
6 cutaneous t cell lymphoma 10.5
7 pustulosis of palm and sole 10.4
8 vasculitis 10.4
9 psoriasis 10.4
10 lymphoma 10.4
11 dermatitis 10.4
12 skin disease 10.3
13 alopecia 10.3
14 neurofibromatosis, type ii 10.2
15 ichthyosis 10.2
16 kaposi sarcoma 10.2
17 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 10.2
18 keratosis 10.2
19 lupus erythematosus 10.2
20 rosacea 10.2
21 lichen planus 10.2
22 human herpesvirus 8 10.1
23 allergic hypersensitivity disease 10.1
24 contact dermatitis 10.1
25 mammary paget's disease 10.1
26 pityriasis rosea 10.1
27 alopecia areata 10.1
28 acanthosis nigricans 9.9
29 ige responsiveness, atopic 9.9
30 mastocytosis, cutaneous 9.9
31 dowling-degos disease 1 9.9
32 vitiligo-associated multiple autoimmune disease susceptibility 6 9.9
33 reticulum cell sarcoma 9.9
34 dermatitis, atopic 9.9
35 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9
36 myocardial infarction 9.9
37 granulomatosis with polyangiitis 9.9
38 leukemia, acute lymphoblastic 9.9
39 anaplastic large cell lymphoma 9.9
40 bone disease 9.9
41 dermatomyositis 9.9
42 lymphocytic leukemia 9.9
43 sarcoma 9.9
44 tinea corporis 9.9
45 telangiectasis 9.9
46 gout 9.9
47 hyperparathyroidism 9.9
48 urticaria 9.9
49 dyskeratosis congenita 9.9
50 allergic contact dermatitis 9.9

Graphical network of the top 20 diseases related to Parapsoriasis:



Diseases related to Parapsoriasis

Symptoms & Phenotypes for Parapsoriasis

Drugs & Therapeutics for Parapsoriasis

Drugs for Parapsoriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
2 Analgesics Phase 4
3 Analgesics, Non-Narcotic Phase 4
4 Angiogenesis Inhibitors Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Peripheral Nervous System Agents Phase 4
7 Anti-Infective Agents Phase 4
8 Angiogenesis Modulating Agents Phase 4
9 Anti-Bacterial Agents Phase 4
10 Immunosuppressive Agents Phase 4
11 Anti-Inflammatory Agents Phase 4
12 Antirheumatic Agents Phase 4
13 Immunologic Factors Phase 4
14
Infliximab Approved Phase 3 170277-31-3
15 Gastrointestinal Agents Phase 3
16 Dermatologic Agents Phase 3
17
Bexarotene Approved, Investigational Phase 2 153559-49-0 82146

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 4, Multicenter, Randomized, Placebo-controlled, Double-blind, Study of the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Moderate Plaque Psoriasis Completed NCT02425826 Phase 4 Apremilast;Placebo;Placebo-Apremilast
2 Safety and Efficacy of Natural Gel Combination and Hair Mask of Plant Origin in Patients With Psoriasis: A Randomized, Double-Blind, Placebo (Vehicle) Controlled Completed NCT02330237 Phase 2, Phase 3 natural gels;Placebo
3 A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Efficacy and Safety of Infliximab Induction Therapy Followed by Multiple Regimens of Maintenance InfliximabTherapy in Patients With Plaque-Type Psoriasis Completed NCT00106847 Phase 3 Infliximab
4 A Phase II Trial to Evaluate the Efficacy of Topical Bexarotene Gel in Patients With Parapsoriasis: a Topical Chemoprevention Strategy for Cutaneous T-cell Lymphoma. Terminated NCT00322296 Phase 2 Bexarotene 1% gel
5 A Phase 1, Multicenter, Randomized, Double-blind, Placebo-controlled, Single and Multiple Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of CC-90005 in Healthy Subjects and Subjects With Moderate to Severe Plaque-type Psoriasis Terminated NCT02502188 Phase 1 CC-90005;Placebo

Search NIH Clinical Center for Parapsoriasis

Cochrane evidence based reviews: parapsoriasis

Genetic Tests for Parapsoriasis

Anatomical Context for Parapsoriasis

MalaCards organs/tissues related to Parapsoriasis:

41
T Cells, Skin, Bone, Lymph Node, Testis, Monocytes, Bone Marrow

Publications for Parapsoriasis

Articles related to Parapsoriasis:

(show top 50) (show all 544)
# Title Authors PMID Year
1
Dermatological manifestations in patients with human T-cell lymphotropic virus at a reference service in Amazon. 38
30888053 2019
2
Dramatic response to brentuximab vedotin in refractory nontransformed CD30- mycosis fungoides allowing allogeneic stem cell transplant and long-term complete remission. 38
30269331 2019
3
JAAD Game Changers: Risk of venous thromboembolism in patients with mycosis fungoides and parapsoriasis: A Danish nationwide population-based cohort study. 38
30521824 2019
4
Frequency of occurrence of polymorphic light eruption in patients treated with photohardening and patients treated with phototherapy for other diseases. 38
30267642 2019
5
[Current possibilities of the differential diagnosis of plaque parapsoriasis and the early stages of mycosis fungoides]. 38
30830099 2019
6
Chlamydiales Bacterial Sequences in Lesional and Healthy Skin of Patients with Parapsoriasis. 38
29956717 2018
7
CD30-Positive Angioinvasive Lymphomatoid Papulosis (Type E) Developing from Parapsoriasis en Plaque. 38
30687061 2018
8
Risk of venous thromboembolism in patients with mycosis fungoides and parapsoriasis: A Danish nationwide population-based cohort study. 38
29203438 2018
9
Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. 38
29795283 2018
10
Branch Duct-type Intraductal Papillary Mucinous Neoplasm Presenting as Paraneoplastic Small Plaque Para-psoriasis. 38
29441297 2018
11
[Discrasia linfoide epiteliotrópica de células T. Tratamiento con radiación ultravioleta]. 38
30532114 2018
12
Defining the mimics and clinico-histological diagnosis criteria for mycosis fungoides to minimize misdiagnosis. 38
28560304 2017
13
Skin Microbiome in Small- and Large-plaque Parapsoriasis. 38
28175925 2017
14
Phototherapy for Pityriasis Lichenoides in the Pediatric Population: A Review of the Published Literature. 38
27502793 2016
15
Systematic review of cases of cutaneous T-cell lymphoma transformation in pityriasis lichenoides and small plaque parapsoriasis. 38
27031678 2016
16
TOX expression and role in CTCL. 38
27345620 2016
17
Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases. 38
26778803 2016
18
Risk of Acute Myocardial Infarction or Stroke in Patients with Mycosis Fungoides and Parapsoriasis. 38
26576854 2016
19
Primary cutaneous lymphomas: the analysis of cases treated in the Department of Dermatology University Hospital in Krakow. 38
29676886 2016
20
Granulomatous slack skin - seven years follow-up of a case with features of "parapsoriasis en plaques", muscle involvement, granulomatous vasculitis, and necrobiotic changes. 38
27516031 2016
21
Lymphomatoid contact dermatitis associated with textile dye at an unusual location. 38
26904444 2015
22
ALK-positive primary cutaneous T-cell-lymphoma (CTCL) with unusual clinical presentation and aggressive course. 38
26053561 2015
23
Frequency of hypopigmented mycosis fungoides in Egyptian patients presenting with hypopigmented lesions of the trunk. 38
26262921 2015
24
Systemic involvement in mycosis fungoides. 38
26321404 2015
25
Poikilodermatous mycosis fungoides: clinical and histopathological analysis of a case and literature review. 38
26086166 2015
26
Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides. 38
26788525 2015
27
Expression of Granulysin and FOXP3 in Cutaneous T Cell Lymphoma and Sézary Syndrome. 38
26225678 2015
28
Benefits of controlled ultraviolet radiation in the treatment of dermatological diseases. 38
25842770 2014
29
Subsequent cancers, mortality, and causes of death in patients with mycosis fungoides and parapsoriasis: a Danish nationwide, population-based cohort study. 38
24836079 2014
30
Efficacy of low-dose ultraviolet a-1 phototherapy for parapsoriasis/early-stage mycosis fungoides. 38
24502428 2014
31
Predictive value of T-cell clone and CD13 antigen in parapsoriasis. 38
23859066 2014
32
Biopsying parapsoriasis: quo vadis? Are morphological stains enough or are ancillary tests needed? 38
25607389 2014
33
Ichthyosiform large plaque parapsoriasis: report of a rare entity. 38
24082186 2013
34
[Mycosis fungoides or inflammatory dermatitis: differential diagnosis between early lymphoma and inflammation in skin biopsies]. 38
23549914 2013
35
Prevalence study of dermatoses referred to the phototherapy unit at the Dermatology Service of the Clinics Hospital of Porto Alegre, RS, Brazil. 38
23739698 2013
36
An evaluation of the treatment of parapsoriasis with phototherapy. 38
23739710 2013
37
Topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis. 38
22229501 2013
38
Hypopigmented parapsoriasis en plaque, a new, overlooked member of the parapsoriasis family: a report of 34 patients and a 7-year experience. 38
22459359 2012
39
Digitate dermatosis (small-plaque parapsoriasis). 38
23286793 2012
40
Narrowband UVB as an effective substitute for psoralen plus UVA: lessons from a psoralen shortage. 38
22971194 2012
41
[What's new in dermatology?]. 38
23316658 2012
42
[Parapsoriasis--to be or not be (mycosis fungoides)]. 38
23316666 2012
43
Retrospective study of 24 patients with large or small plaque parapsoriasis treated with ultraviolet B therapy. 38
21973175 2012
44
Trichophyton Schoenleinii-induced widespread tinea corporis mimicking parapsoriasis. 38
23518026 2012
45
[To the problem of parapsoriasis: classification problems (literature review and personal observations)]. 38
23356135 2012
46
Epidermotropic CD8+ cytotoxic T-cell lymphoma exhibiting a transition from the indolent to the aggressive phase, accompanied by emergence of CD7+ cells and formation of neutrophilic pustules. 38
21883402 2012
47
Fixed drug eruption: the dark side of activation of intraepidermal CD8+ T cells uniquely specialized to mediate protective immunity. 38
22613857 2012
48
Consistency and distribution of reflectance confocal microscopy features for diagnosis of cutaneous T cell lymphoma. 38
22352651 2012
49
Human herpesvirus 8 is not detectable in lesions of large plaque parapsoriasis, and in early-stage sporadic, familial, and juvenile cases of mycosis fungoides. 38
21704421 2012
50
Up-regulation of the chemokine CCL18 by macrophages is a potential immunomodulatory pathway in cutaneous T-cell lymphoma. 38
21741937 2011

Variations for Parapsoriasis

Expression for Parapsoriasis

Search GEO for disease gene expression data for Parapsoriasis.

Pathways for Parapsoriasis

GO Terms for Parapsoriasis

Cellular components related to Parapsoriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD8A CD5 CD4
2 T cell receptor complex GO:0042101 8.62 CD8A CD4

Biological processes related to Parapsoriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.96 CD8A CD4
2 T cell activation GO:0042110 8.62 CD8A CD4

Molecular functions related to Parapsoriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.62 CD8A CD4

Sources for Parapsoriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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