MCID: PRP005
MIFTS: 35

Parapsoriasis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Parapsoriasis

MalaCards integrated aliases for Parapsoriasis:

Name: Parapsoriasis 12 76 53 44 15 73
Parapsoriasis En Plaques 73
Parapsoriasis En Plaque 53
Digitate Dermatosis 53

Classifications:



External Ids:

Disease Ontology 12 DOID:9088
ICD10 33 L41 L41.9
ICD9CM 35 696.2
MeSH 44 D010267
NCIt 50 C3312

Summaries for Parapsoriasis

NIH Rare Diseases : 53 Parapsoriasis describes a group of skin diseases that can be characterized by scaly patches or slightly elevated papules and/or plaques (red, scaly patches) that have a resemblance to psoriasis. However, this description includes several inflammatory cutaneous diseases that are unrelated with respect to pathogenesis, histopathology, and response to treatment. Because of the variation in clinical presentation and a lack of a specific diagnostic finding on histopathology, a uniformly accepted definition of parapsoriasis remains lacking. There are 2 general forms: a small plaque type, which is usually benign, and a large plaque type, which is a precursor of cutaneous T-cell lymphoma (CTCL). Treatment of small plaque parapsoriasis is unnecessary but can include emollients, topical tar preparations or corticosteroids, and/or phototherapy. Treatment of large plaque parapsoriasis is phototherapy or topical corticosteroids.

MalaCards based summary : Parapsoriasis, also known as parapsoriasis en plaques, is related to pityriasis lichenoides chronica and pityriasis lichenoides et varioliformis acuta. An important gene associated with Parapsoriasis is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are NAD metabolism and Amino Acid metabolism. The drugs Apremilast and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes.

Wikipedia : 76 Parapsoriasis refers to one of a group of skin disorders that are characterized primarily by their... more...

Related Diseases for Parapsoriasis

Graphical network of the top 20 diseases related to Parapsoriasis:



Diseases related to Parapsoriasis

Symptoms & Phenotypes for Parapsoriasis

Drugs & Therapeutics for Parapsoriasis

Drugs for Parapsoriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
2 Analgesics Phase 4
3 Analgesics, Non-Narcotic Phase 4
4 Angiogenesis Inhibitors Phase 4
5 Angiogenesis Modulating Agents Phase 4
6 Peripheral Nervous System Agents Phase 4
7 Anti-Bacterial Agents Phase 4
8 Immunosuppressive Agents Phase 4
9 Anti-Infective Agents Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Antirheumatic Agents Phase 4,Phase 3
13
Infliximab Approved Phase 3 170277-31-3
14 Gastrointestinal Agents Phase 3
15 Dermatologic Agents Phase 3
16
Bexarotene Approved, Investigational Phase 2 153559-49-0 82146
17 Protective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 4 Study of Efficacy and Safety of Apremilast in Subjects With Moderate Plaque Psoriasis. Completed NCT02425826 Phase 4 Apremilast;Placebo;Placebo-Apremilast
2 A Study of the Safety and Effectiveness of Infliximab in Patients With Plaque-type Psoriasis Completed NCT00106847 Phase 3 Infliximab
3 Natural Gels for Treatment of Plaque Psoriasis Unknown status NCT02330237 Phase 1, Phase 2 natural gels;Placebo
4 Phase II Trial to Evaluate the Efficacy of Topical Bexarotene Gel in Patients With Parapsoriasis Terminated NCT00322296 Phase 2 Bexarotene 1% gel
5 Phase 1 Study of CC-90005 in Healthy Subjects and Subjects With Moderate to Severe Plaque-type Psoriasis Terminated NCT02502188 Phase 1 CC-90005;Placebo

Search NIH Clinical Center for Parapsoriasis

Cochrane evidence based reviews: parapsoriasis

Genetic Tests for Parapsoriasis

Anatomical Context for Parapsoriasis

MalaCards organs/tissues related to Parapsoriasis:

41
Skin, T Cells, Testes

Publications for Parapsoriasis

Articles related to Parapsoriasis:

(show top 50) (show all 193)
# Title Authors Year
1
Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. ( 29795283 )
2018
2
Chlamydiales Bacterial Sequences in Lesional and Healthy Skin of Patients with Parapsoriasis. ( 29956717 )
2018
3
Risk of venous thromboembolism in patients with mycosis fungoides and parapsoriasis: A Danish nationwide population-based cohort study. ( 29203438 )
2017
4
Skin Microbiome in Small- and Large-plaque Parapsoriasis. ( 28175925 )
2017
5
Systematic Review of Cases of Cutaneous T-Cell Lymphoma Transformation in Pityriasis Lichenoides and Small Plaque Parapsoriasis. ( 27031678 )
2016
6
Granulomatous slack skin - seven years follow-up of a case with features of "parapsoriasis en plaques", muscle involvement, granulomatous vasculitis, and necrobiotic changes. ( 27516031 )
2016
7
Risk of Acute Myocardial Infarction or Stroke in Patients with Mycosis Fungoides and Parapsoriasis. ( 26576854 )
2016
8
Subsequent cancers, mortality, and causes of death in patients with mycosis fungoides and parapsoriasis: a Danish nationwide, population-based cohort study. ( 24836079 )
2014
9
Efficacy of low-dose ultraviolet a-1 phototherapy for parapsoriasis/early-stage mycosis fungoides. ( 24502428 )
2014
10
Biopsying parapsoriasis: quo vadis? Are morphological stains enough or are ancillary tests needed? ( 25607389 )
2014
11
Ichthyosiform large plaque parapsoriasis: report of a rare entity. ( 24082186 )
2013
12
An evaluation of the treatment of parapsoriasis with phototherapy. ( 23739710 )
2013
13
Topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis. ( 22229501 )
2013
14
Predictive value of T-cell clone and CD13 antigen in parapsoriasis. ( 23859066 )
2013
15
Digitate dermatosis (small-plaque parapsoriasis). ( 23286793 )
2012
16
Hypopigmented parapsoriasis en plaque, a new, overlooked member of the parapsoriasis family: a report of 34 patients and a 7-year experience. ( 22459359 )
2012
17
[Parapsoriasis--to be or not be (mycosis fungoides)]. ( 23316666 )
2012
18
Retrospective study of 24 patients with large or small plaque parapsoriasis treated with ultraviolet B therapy. ( 21973175 )
2012
19
Trichophyton Schoenleinii-induced widespread tinea corporis mimicking parapsoriasis. ( 23518026 )
2012
20
Human herpesvirus 8 is not detectable in lesions of large plaque parapsoriasis, and in early-stage sporadic, familial, and juvenile cases of mycosis fungoides. ( 21704421 )
2012
21
The role of immunohistochemical analysis in the diagnosis of parapsoriasis. ( 20083298 )
2011
22
Large plaque parapsoriasis with the "deck-chair" sign successfully treated with bath psoralen and ultraviolet A therapy. ( 20536677 )
2010
23
The conundrum of parapsoriasis versus patch stage of mycosis fungoides. ( 19439874 )
2009
24
Parapsoriasis lichenoides/parapsoriasis variegata--a new concept. ( 21465693 )
2009
25
Evaluation of the role of human herpes virus 6 and 8 in parapsoriasis. ( 18803660 )
2009
26
Treatment of parapsoriasis with bexarotene 1% gel. ( 19126035 )
2008
27
A patient with clinicopathologic features of small plaque parapsoriasis presenting later with plaque-stage mycosis fungoides: report of a case and comparative retrospective study of 27 cases of "nonprogressive" small plaque parapsoriasis. ( 18694680 )
2008
28
High association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides. ( 18711073 )
2008
29
Anaplastic large cell lymphoma associated with parapsoriasis en plaques. ( 18480948 )
2008
30
I^I' T cells as potential contributors to the progression of parapsoriasis to mycosis fungoides. ( 21479436 )
2008
31
Immunohistochemical analysis of small plaque parapsoriasis: involvement of dendritic cells. ( 18258285 )
2008
32
Early-stage mycosis fungoides, parapsoriasis en plaque, and pregnancy. ( 17269968 )
2007
33
Parapsoriasis: a complex issue. ( 17975354 )
2007
34
Retroperitoneal liposarcoma associated with small plaque parapsoriasis. ( 17620118 )
2007
35
Expression of HECA-452 in parapsoriasis and mycosis fungoides. ( 16569348 )
2006
36
Analysis of p53 gene mutations in parapsoriasis. ( 16898923 )
2006
37
Excimer-laser (308 nm) treatment of large plaque parapsoriasis and long-term follow-up. ( 16613751 )
2006
38
Narrowband UVB phototherapy for small plaque parapsoriasis. ( 16684286 )
2006
39
Lymphoma with large-plaque parapsoriasis treated with PUVA. ( 16048755 )
2005
40
Treatment of small plaque parapsoriasis with narrow-band (311 nm) ultraviolet B: a retrospective study. ( 15953075 )
2005
41
A retrospective study of the probability of the evolution of parapsoriasis en plaques into mycosis fungoides. ( 16191852 )
2005
42
Analysis of T-cell receptor gamma gene rearrangements by PCR-Genescan and PCR-polyacrylamide gel electrophoresis in early-stage mycosis fungoides/large-plaque parapsoriasis. ( 14657643 )
2003
43
Psoriasis and parapsoriasis: since 200 and 100 years, respectively. ( 12705739 )
2003
44
Absence of Epstein-Barr virus and human herpesvirus-6 in pityriasis lichenoides and plaque parapsoriasis. ( 12428859 )
2002
45
Demonstration of characteristic skin surface contours of extramammary Paget's disease and parapsoriasis en plaque by image analysis of negative impression replicas. ( 12354416 )
2002
46
Clonal T cell receptor gamma-chain gene rearrangement by PCR-based GeneScan analysis in the skin and blood of patients with parapsoriasis and early-stage mycosis fungoides. ( 12115881 )
2002
47
Cytokine production profile of peripheral blood mononuclear cells in patients with large-plaque parapsoriasis. ( 11453828 )
2001
48
Shortened telomere length is demonstrated in T-cell subsets together with a pronounced increased telomerase activity in CD4 positive T cells from blood of patients with mycosis fungoides and parapsoriasis. ( 11589730 )
2001
49
Large plaque parapsoriasis: clinical and genotypic correlations. ( 10678699 )
2000
50
UVA1 cold-light phototherapy of small plaque parapsoriasis. ( 11200849 )
2000

Variations for Parapsoriasis

Expression for Parapsoriasis

Search GEO for disease gene expression data for Parapsoriasis.

Pathways for Parapsoriasis

Pathways related to Parapsoriasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.2 ALPP TDO2
2 10.58 OAT TDO2

GO Terms for Parapsoriasis

Sources for Parapsoriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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