MCID: PRQ002
MIFTS: 26

Paraquat Poisoning

Categories: Rare diseases

Aliases & Classifications for Paraquat Poisoning

MalaCards integrated aliases for Paraquat Poisoning:

Name: Paraquat Poisoning 58

Characteristics:

Orphanet epidemiological data:

58
paraquat poisoning
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

ICD10 via Orphanet 33 T60.3
Orphanet 58 ORPHA31827

Summaries for Paraquat Poisoning

MalaCards based summary : Paraquat Poisoning is related to cholestasis and fatty liver disease, nonalcoholic 1. An important gene associated with Paraquat Poisoning is GPT (Glutamic--Pyruvic Transaminase). The drugs Vitamin C and Vitamins have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and skin.

Related Diseases for Paraquat Poisoning

Diseases related to Paraquat Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 cholestasis 30.2 SLC17A5 GPT
2 fatty liver disease, nonalcoholic 1 29.6 SLC17A5 GPT
3 acute liver failure 29.6 SLC17A5 GPT
4 myopathy 28.7 SOD1 SLC17A5 GPT
5 pulmonary fibrosis 10.9
6 respiratory failure 10.8
7 acute kidney failure 10.6
8 pulmonary edema 10.5
9 paraquat lung 10.4
10 48,xyyy 10.4
11 fibrosis of extraocular muscles, congenital, 1 10.3
12 kidney disease 10.3
13 acute kidney tubular necrosis 10.3
14 hypokalemia 10.3
15 metabolic acidosis 10.2
16 adult respiratory distress syndrome 10.2
17 pneumothorax 10.2
18 cytokine deficiency 10.2
19 neutropenia 10.1
20 diarrhea 10.1
21 acute pancreatitis 10.1
22 myocarditis 10.1
23 scabies 10.1
24 toxic myocarditis 10.1
25 anoxia 10.1
26 hypoxia 10.1
27 myositis 10.0
28 pneumothorax, primary spontaneous 10.0
29 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
30 ocular motor apraxia 10.0
31 respiratory distress syndrome in premature infants 10.0
32 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.0
33 severe cutaneous adverse reaction 10.0
34 leukemia, acute lymphoblastic 3 10.0
35 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.0
36 deficiency anemia 10.0
37 pulmonary hypertension 10.0
38 erythema multiforme 10.0
39 hypophosphatemia 10.0
40 exanthem 10.0
41 renal fibrosis 10.0
42 cardiac arrest 10.0
43 thrombosis 10.0
44 bacterial infectious disease 10.0
45 interstitial nephritis 10.0
46 dysthymic disorder 10.0
47 newborn respiratory distress syndrome 10.0
48 acute cystitis 10.0
49 beriberi 10.0
50 toxic shock syndrome 10.0

Graphical network of the top 20 diseases related to Paraquat Poisoning:



Diseases related to Paraquat Poisoning

Symptoms & Phenotypes for Paraquat Poisoning

Drugs & Therapeutics for Paraquat Poisoning

Drugs for Paraquat Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
2 Vitamins Phase 4
3
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
4
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
6 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
7
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
8
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
9 Methylprednisolone Acetate Phase 2
10 Immunosuppressive Agents Phase 2
11 Anti-Infective Agents Phase 2
12 interferons Phase 2
13 Anti-Bacterial Agents Phase 2
14 Immunologic Factors Phase 2
15 Angiogenesis Inhibitors Phase 2
16 Hormones Phase 2
17 Antioxidants
18 Charcoal
19 Dialysis Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Low Dose Euthyrox in Treatments of Paraquat Intoxication: a Randomized, Controlled, Multicenter Trial in China. Not yet recruiting NCT04132622 Phase 4 Levothyroxine Sodium;Traditional therapy
2 Safety and Efficacy of Human Umbilical-Cord-derived Mesenchymal Stem Cell Transplantation in Paraquat Poisoning Induced Lung Injury Unknown status NCT02444858 Phase 1, Phase 2
3 The Efficacy and Safety of Thalidomide Combined With Low-dose Hormones in the Treatment of Severe New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study Not yet recruiting NCT04273581 Phase 2 placebo;Thalidomide
4 The Efficacy and Safety of Thalidomide in the Adjuvant Treatment of Moderate New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study Not yet recruiting NCT04273529 Phase 2 thalidomide;placebo
5 The Efficacy and Safety of Continuous Venovenous Hemofiltration in Patients With Severe Acute Paraquat Poisoning Completed NCT01709604
6 The Efficacy of Initial Hemopurification Strategy for Acute Paraquat Poisoning in Adults: Study Protocol for a Randomized Controlled Trial (HeSAPP) Not yet recruiting NCT03314909

Search NIH Clinical Center for Paraquat Poisoning

Genetic Tests for Paraquat Poisoning

Anatomical Context for Paraquat Poisoning

MalaCards organs/tissues related to Paraquat Poisoning:

40
Lung, Kidney, Skin, Liver, Neutrophil, Brain, Endothelial

Publications for Paraquat Poisoning

Articles related to Paraquat Poisoning:

(show top 50) (show all 887)
# Title Authors PMID Year
1
Osteonecrosis of Femoral Head, An Overlooked Long-Term Complication after Paraquat Intoxication: A Retrospective Cohort Study. 61
32483235 2020
2
Dynamic assessment of lung injury by ultrasound in patients with acute paraquat poisoning. 61
32363962 2020
3
Correlation between neutrophil gelatinase-associated lipocalin and soluble CD14 subtype on the prognosis evaluation of acute paraquat poisoning patients. 61
31957486 2020
4
Clinical significance of serum levels of microRNA-27a and its correlation with interleukin-10 in patients with multiple organ dysfunction syndrome caused by acute paraquat poisoning. 61
32104255 2020
5
Hyperamylasemia as an early predictor of mortality in patients with acute paraquat poisoning. 61
32223576 2020
6
Paraquat Poisoning: A Retrospective Study of 55 Patients From a Tertiary Care Center in Southern India. 61
32435092 2020
7
[CT manifestations and prognosis of acute paraquat induced lung injury]. 61
32306680 2020
8
[The assessment value of urinary NGAL combined with blood NLR in the early prognosis of patients with acute paraquat poisoning]. 61
32306679 2020
9
Comparison of severity index and plasma paraquat concentration for predicting survival after paraquat poisoning: A meta-analysis. 61
32028427 2020
10
Antioxidant studies of citric acid and citrus fruits towards paraquat by cyclic voltammetry: An antidote of paraquat poisoning. 61
32122857 2020
11
Evaluation of gastric lavage efficiency and utility using a rapid quantitative method in a swine paraquat poisoning model. 61
32351651 2020
12
Silymarin as a Promising Potential Therapeutic Agent for Treatment of Patients with Paraquat Poisoning: An Issue that Merits Further Research. 61
32322784 2020
13
Paraquat Poisoning. 61
31995221 2020
14
Immunosuppressive drugs to reduce the mortality rate in patients with moderate to severe paraquat poisoning: A Meta-analysis. 61
32147639 2020
15
Fetal outcomes after intentional ingestion of paraquat: A case report. 61
31895766 2020
16
Disease Profile of Paraquat Poisoning: Andaman and Nicobar experiences (Indian Islands) - DP3 study. 61
31979957 2020
17
Paraquat: The Poison Potion. 61
32021001 2019
18
Accidental paraquat induced hypersalivation: a case report. 61
31489576 2019
19
Cardioprotective Effects of Atorvastatin Are Mediated Through PPARγ in Paraquat-Exposed Rats. 61
31425380 2019
20
[Xuebijing improves clinical prognosis and reduces mortality in patients with acute paraquat poisoning: a Meta-analysis included 1 429 patients]. 61
31898576 2019
21
Ventilator settings and outcome of respiratory failure in paraquat-induced pulmonary injury. 61
31719587 2019
22
Radiomics Nomogram Analyses for Differentiating Pneumonia and Acute Paraquat Lung Injury. 61
31636276 2019
23
Lymphocyte and its CD4+ and CD8+ subgroup changes after paraquat poisoning. 61
31104516 2019
24
Neutrophil-lymphocyte ratio as an early predictor for patients with acute paraquat poisoning: A retrospective analysis. 61
31517877 2019
25
Homicidal Paraquat Poisoning Following Ligature Strangulation. 61
32110256 2019
26
Clinical outcome of paraquat poisoning during pregnancy. 61
30689470 2019
27
[Early white blood cell count in predicting mortality after acute paraquat poisoning: a Meta-analysis]. 61
31537230 2019
28
[Experience of continuous fluid therapy in successfully rescuing a patient with acute severe paraquat poisoning]. 61
31537237 2019
29
Systemic Paraquat Intoxication Presenting with Peripheral Ulcerative Keratitis: A Case Report and Literature Review. 61
31411945 2019
30
Systematic review and meta-analysis of the efficacy and safety of immunosuppressive pulse therapy in the treatment of paraquat poisoning. 61
31168972 2019
31
Paraquat Poisoning in Children: A 5-Year Review. 61
31181023 2019
32
Base excess in predicting the prognosis of patients with paraquat poisoning: A meta-analysis. 61
31169729 2019
33
Review of a Case of Paraquat Poisoning in a Tertiary Care Rural-based ICU. 61
31435149 2019
34
The significance of serum HMGB1 level in humans with acute paraquat poisoning. 61
31092889 2019
35
Homicidal Paraquat Poisoning. 61
30452771 2019
36
Retrospective study of clinical features and prognosis of edaravone in the treatment of paraquat poisoning. 61
31083174 2019
37
Effects of curcumin on artery blood gas index of rats with pulmonary fibrosis caused by paraquat poisoning and the expression of Smad 4, Smurf 2, interleukin-4 and interferon-γ. 61
30988750 2019
38
A Facile, Versatile, and Highly Efficient Strategy for Peroxynitrite Bioimaging Enabled by Formamide Deformylation. 61
31001973 2019
39
Commentary on: Chen F, Ye Y, Jin B, Yi B, Wei Q, Liao L. Homicidal paraquat poisoning. J Forensic Sci https://doi.org/10.1111/1556-4029.13945. Epub 2018 Nov 19. 61
31077375 2019
40
Metabolitic profiling of amino acids in paraquat-induced acute kidney injury. 61
30859350 2019
41
Metabolomics Analysis in Acute Paraquat Poisoning Patients Based on UPLC-Q-TOF-MS and Machine Learning Approach. 61
30807114 2019
42
[Lung transplantation in patients with paraquat poisoning: a case report and literature review]. 61
31177699 2019
43
Mesenchymal Stem Cells Alleviate Acute Lung Injury and Inflammatory Responses Induced by Paraquat Poisoning. 61
30967525 2019
44
Burden of paraquat poisoning in the department of Antioquia, Colombia. 61
30767779 2019
45
[Clinical effect of haemoperfusion combined with continuous veno-veno haemofiltration in treatment of paraquat poisoning: a Meta-analysis]. 61
30827312 2019
46
The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning. 61
30392424 2019
47
Increased 90-Day Mortality in Spontaneously Breathing Patients With Paraquat Poisoning: In Addition to Disease Severity, Lung Strain May Play a Role. 61
30371520 2019
48
Does hemoperfusion in combination with other treatments reduce the mortality of patients with paraquat poisoning more than hemoperfusion alone: A systematic review with meta-analysis. 61
30815015 2019
49
The successful treatment of systemic toxic induced paraquat poisoning by skin absorption: case reports and a literature review. 61
31934217 2019
50
Metformin Activates the Protective Effects of the AMPK Pathway in Acute Lung Injury Caused by Paraquat Poisoning. 61
31781324 2019

Variations for Paraquat Poisoning

Expression for Paraquat Poisoning

Search GEO for disease gene expression data for Paraquat Poisoning.

Pathways for Paraquat Poisoning

GO Terms for Paraquat Poisoning

Biological processes related to Paraquat Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 8.62 SOD1 MIR146A

Sources for Paraquat Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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