MCID: PRQ002
MIFTS: 26

Paraquat Poisoning

Categories: Rare diseases

Aliases & Classifications for Paraquat Poisoning

MalaCards integrated aliases for Paraquat Poisoning:

Name: Paraquat Poisoning 59

Characteristics:

Orphanet epidemiological data:

59
paraquat poisoning
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Orphanet 59 ORPHA31827
ICD10 via Orphanet 34 T60.3

Summaries for Paraquat Poisoning

MalaCards based summary : Paraquat Poisoning is related to hepatitis and pulmonary fibrosis. An important gene associated with Paraquat Poisoning is GPT (Glutamic--Pyruvic Transaminase). The drugs Prednisolone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and liver.

Related Diseases for Paraquat Poisoning

Graphical network of the top 20 diseases related to Paraquat Poisoning:



Diseases related to Paraquat Poisoning

Symptoms & Phenotypes for Paraquat Poisoning

Drugs & Therapeutics for Paraquat Poisoning

Drugs for Paraquat Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved 50-24-8 5755
2
Methylprednisolone Approved, Vet_approved 83-43-2 6741
3 Prednisolone acetate
4 Methylprednisolone acetate
5 Methylprednisolone Hemisuccinate
6 Charcoal
7 Dialysis Solutions
8 Prednisolone hemisuccinate
9 Prednisolone phosphate
10 Antioxidants
11 Immunosuppressive Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Paraquat Poisoning Induced Lung Injury Unknown status NCT02444858 Phase 1, Phase 2
2 Role of CVVH in Patients With Acute Paraquat Poisoning Completed NCT01709604
3 Initial Hemopurification Strategy for Acute Paraquat Poisoning in Adults Not yet recruiting NCT03314909 Not Applicable

Search NIH Clinical Center for Paraquat Poisoning

Genetic Tests for Paraquat Poisoning

Anatomical Context for Paraquat Poisoning

MalaCards organs/tissues related to Paraquat Poisoning:

41
Lung, Skin, Liver, Kidney, Endothelial, Testes, Bone

Publications for Paraquat Poisoning

Articles related to Paraquat Poisoning:

(show top 50) (show all 402)
# Title Authors Year
1
Patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function: A retrospective analysis. ( 29668605 )
2018
2
Paraquat poisoning calls to the Malaysia National Poison Centre following its ban and subsequent restriction of the herbicide from 2004 to 2015. ( 29525581 )
2018
3
Clinical features and prognosis of paraquat poisoning in French Guiana: A review of 62 cases. ( 29642226 )
2018
4
Metabolic Profiling of Amino Acids Associated with Mortality in Patients with Acute Paraquat Poisoning. ( 29513648 )
2018
5
Treatment Outcome of Combined Continuous Venovenous Hemofiltration and Hemoperfusion in Acute Paraquat Poisoning: A Prospective Controlled Trial. ( 29116999 )
2018
6
Mesenchymal stem cell therapy for paraquat poisoning: A systematic review and meta-analysis of preclinical studies. ( 29566055 )
2018
7
Efficacy of initial haemopurification strategy for acute paraquat poisoning in adults: study protocol for a randomised controlled trial (HeSAPP). ( 29934393 )
2018
8
HIV and paraquat poisoning: fighting fire with fire? ( 29405044 )
2018
9
Increased plasma prothrombin time is associated with poor prognosis in patients with paraquat poisoning. ( 29943421 )
2018
10
Is endotracheal intubation a non-beneficial treatment in patients with respiratory failure due to paraquat poisoning? ( 29590187 )
2018
11
Effect of activated charcoal hemoperfusion on renal function in patients with paraquat poisoning. ( 29456670 )
2018
12
Lung injury caused by paraquat poisoning results in increased interleukin-6 and decreased microRNA-146a levels. ( 29896267 )
2018
13
Investigation Paraquat Poisoning in Southwest of Iran - from Sign to Mortality and Morbidity. ( 28972357 )
2017
14
Golden Hours in Severe Paraquat Poisoning-The Role of Early Haemoperfusion Therapy. ( 28384906 )
2017
15
Prolonged methylprednisolone therapy after the pulse treatment for patients with moderate-to-severe paraquat poisoning: A retrospective analysis. ( 28640126 )
2017
16
Paraquat poisoning induced pulmonary epithelial mesenchymal transition through Notch1 pathway. ( 28424456 )
2017
17
Clinical screening of paraquat in plasma samples using capillary electrophoresis with contactless conductivity detection: Towards rapid diagnosis and therapeutic treatment of acute paraquat poisoning in Vietnam. ( 28609698 )
2017
18
Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning. ( 28672896 )
2017
19
Discernment scheme for paraquat poisoning: A five-year experience in Shiraz, Iran. ( 28261553 )
2017
20
Experimental study of sucralfate intervention for paraquat poisoning in rats. ( 28501785 )
2017
21
Time-dependent haemoperfusion after acute paraquat poisoning. ( 28533543 )
2017
22
Paraquat poisoning: Case report of a survivor. ( 29417032 )
2017
23
Paraquat poisoning: Acute lung injury - a missed diagnosis. ( 28492119 )
2017
24
Continuous venovenous hemofiltration in the management of paraquat poisoning: A meta-analysis of randomized controlled trials. ( 28514303 )
2017
25
Tissue metabolic changes for effects of pirfenidone in rats of acute paraquat poisoning by GC-MS. ( 28978283 )
2017
26
A rare case of epilepsy and acute pancreatitis induced by severe paraquat poisoning. ( 28480199 )
2017
27
Effects of hemoperfusion and continuous renal replacement therapy on patient survival following paraquat poisoning. ( 28704509 )
2017
28
Prognostic comparison of goal-oriented hemoperfusion and routine hemoperfusion combined with continuous venovenous hemofiltration for paraquat poisoning. ( 29082819 )
2017
29
The value of APACHE II in predicting mortality after paraquat poisoning in Chinese and Korean population: A systematic review and meta-analysis. ( 28746171 )
2017
30
HIF-1I+ regulates EMT via the Snail and I^-catenin pathways in paraquat poisoning-induced early pulmonary fibrosis. ( 26781174 )
2016
31
Early Stage Blood Purification for Paraquat Poisoning: A Multicenter Retrospective Study. ( 27189189 )
2016
32
Hypokalemia is a biochemical signal of poor prognosis for acute paraquat poisoning within 4A hours. ( 27395362 )
2016
33
Prognostic value of hematological parameters in patients with paraquat poisoning. ( 27824090 )
2016
34
An Effective Machine Learning Approach for Prognosis of Paraquat Poisoning Patients Using Blood Routine Indexes. ( 27390221 )
2016
35
Paraquat Poisoning: A Case Report. ( 27042505 )
2016
36
Predicting the probability of survival in acute paraquat poisoning. ( 27366665 )
2016
37
Paraquat Poisoning in Patients With HIV Infection: A Case Report and Literature Review. ( 27057917 )
2016
38
Comparision of clinical outcome of paraquat poisoning in patients treated with and without methylprednisolone. ( 27728609 )
2016
39
Fanconi syndrome in paraquat poisoning. ( 27728607 )
2016
40
An intelligent prognostic system for analyzing patients with paraquat poisoning using arterial blood gas indexes. ( 27884773 )
2016
41
Hyperamylasemia as an Early Predictor of Mortality in Patients with Acute Paraquat Poisoning. ( 27101346 )
2016
42
Paper-based diagnostic devices for clinical paraquat poisoning diagnosis. ( 27462379 )
2016
43
Successful extracorporeal membrane oxygenation therapy as a bridge to sequential bilateral lung transplantation for a patient after severe paraquat poisoning. ( 26314316 )
2015
44
Efficacy and safety of pulse immunosuppressive therapy with glucocorticoid and cyclophosphamide in patients with paraquat poisoning: A meta-analysis. ( 25921027 )
2015
45
A case report of severe paraquat poisoning in an HIV-positive patient: an unexpected outcome and inspiration. ( 25715264 )
2015
46
745: PARAQUAT POISONING CAUSING MULTI-ORGAN FAILURE IN SOUTH-INDIA. ( 26570406 )
2015
47
[Effect of rhubarb as the main composition of sequential treatment in patients with acute paraquat poisoning: a prospective clinical research]. ( 25891453 )
2015
48
Abnormal pancreatic enzymes and their prognostic role after acute paraquat poisoning. ( 26603772 )
2015
49
PSTK is a novel gene associated with early lung injury in Paraquat Poisoning. ( 25592138 )
2015
50
Serum Metabolomics in Rats after Acute Paraquat Poisoning. ( 26133715 )
2015

Variations for Paraquat Poisoning

Expression for Paraquat Poisoning

Search GEO for disease gene expression data for Paraquat Poisoning.

Pathways for Paraquat Poisoning

GO Terms for Paraquat Poisoning

Cellular components related to Paraquat Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 8.62 SLC17A5 SOD1

Sources for Paraquat Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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