MCID: PRS036
MIFTS: 48

Parasitic Protozoa Infectious Disease

Categories: Cancer diseases, Infectious diseases

Aliases & Classifications for Parasitic Protozoa Infectious Disease

MalaCards integrated aliases for Parasitic Protozoa Infectious Disease:

Name: Parasitic Protozoa Infectious Disease 12 15
Protozoan Infections 44 73
Sarcomastigophora Infectious Disease 12
Mastigophora Infectious Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2789
ICD10 33 B50-B64 B64
MeSH 44 D011528
NCIt 50 C34953
SNOMED-CT 68 89933001 95896000
UMLS 73 C0033740

Summaries for Parasitic Protozoa Infectious Disease

Disease Ontology : 12 A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes.

MalaCards based summary : Parasitic Protozoa Infectious Disease, also known as protozoan infections, is related to trypanosomiasis and coccidiosis. An important gene associated with Parasitic Protozoa Infectious Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Allograft rejection and Influenza A. Affiliated tissues include t cells, lung and bone, and related phenotype is digestive/alimentary.

Related Diseases for Parasitic Protozoa Infectious Disease

Diseases related to Parasitic Protozoa Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 trypanosomiasis 32.1 ICAM1 IFNG IL10 IL2 IL4 TLR9
2 coccidiosis 32.0 HSPA4 IFNG IL10 IL2 IL4 MT-CYB
3 leishmaniasis 32.0 HSPA4 IFNG IL10 IL2 IL4 LMLN
4 malaria 31.4 ACKR1 HSPA4 ICAM1 IFNG IL10 IL2
5 gastroenteritis 30.4 IL10 IL4 TNF
6 filarial elephantiasis 30.3 IL10 IL4 TLR9
7 echinococcosis 30.3 IFNG IL10 MT-CO1 TNF
8 toxoplasmosis 30.2 IFNG IL10 IL4 TLR9 TNF
9 filariasis 30.2 IFNG IL10 IL2 TLR9 TNF
10 cryptosporidiosis 11.3
11 primary amebic meningoencephalitis 11.3
12 granulomatous amebic encephalitis 11.3
13 giardiasis 11.3
14 balantidiasis 11.3
15 trichomoniasis 11.3
16 theileriasis 11.3
17 amebiasis 11.3
18 dientamoebiasis 11.3
19 babesiosis 11.3
20 protozoal dysentery 11.0
21 eye lymphoma 10.4 IL10 TLR9
22 mixed malaria 10.4 ACKR1 MT-CYB
23 transient hypogammaglobulinemia 10.4 IL10 TNF
24 microscopic polyangiitis 10.4 IL10 TNF
25 multifocal choroiditis 10.4 IL10 TNF
26 cephalosporin allergy 10.4 IFNG IL10
27 cerebral lymphoma 10.4 TCN2 TLR9
28 sporotrichosis 10.4 IFNG IL10
29 trichosporonosis 10.4 IFNG TNF
30 b-cell growth factor 10.4 IFNG IL4
31 staphylococcal toxic shock syndrome 10.4 IFNG TNF
32 chronic beryllium disease 10.4 IFNG TNF
33 sparganosis 10.4 MT-CO1 MT-CYB
34 autoimmune vasculitis 10.4 IL2 IL4
35 streptococcal toxic-shock syndrome 10.4 IL2 TNF
36 variola major 10.4 IFNG IL2
37 virus associated hemophagocytic syndrome 10.4 IL2 IL4
38 berylliosis 10.4 IFNG IL2
39 fixed drug eruption 10.4 IFNG IL2
40 toxicodendron dermatitis 10.4 ICAM1 IL2
41 bacterial meningitis 10.4 IL10 TLR9 TNF
42 irritable bowel syndrome 10.4 IL10 TLR9 TNF
43 chronic granulomatous disease 10.4 IFNG MT-CYB TLR9
44 otitis media 10.4 IL10 IL4 TNF
45 rubella 10.4 IL10 IL4 TNF
46 osteomyelitis 10.4 IFNG IL10 TNF
47 chronic mucocutaneous candidiasis 10.4 IFNG IL10 TNF
48 urinary system disease 10.4 IL2 TLR9 TNF
49 arteries, anomalies of 10.4 ICAM1 TLR9 TNF
50 food allergy 10.4 IFNG IL10 IL4

Graphical network of the top 20 diseases related to Parasitic Protozoa Infectious Disease:



Diseases related to Parasitic Protozoa Infectious Disease

Symptoms & Phenotypes for Parasitic Protozoa Infectious Disease

MGI Mouse Phenotypes related to Parasitic Protozoa Infectious Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 ICAM1 IFNG IL10 IL2 IL4 TLR9

Drugs & Therapeutics for Parasitic Protozoa Infectious Disease

Genetic Tests for Parasitic Protozoa Infectious Disease

Anatomical Context for Parasitic Protozoa Infectious Disease

MalaCards organs/tissues related to Parasitic Protozoa Infectious Disease:

41
T Cells, Lung, Bone, Heart, Lymph Node, Eye, Thyroid

Publications for Parasitic Protozoa Infectious Disease

Articles related to Parasitic Protozoa Infectious Disease:

(show top 50) (show all 98)
# Title Authors Year
1
Island-Wide Surveillance of Gastrointestinal Protozoan Infections on Fiji by Expanding Lymphatic Filariasis Transmission Assessment Surveys as an Access Platform. ( 29405101 )
2018
2
Effects of Water, Sanitation, Handwashing, and Nutritional Interventions on Child Enteric Protozoan Infections in Rural Bangladesh: A Cluster-Randomized Controlled Trial. ( 29669039 )
2018
3
Human Kinetoplastid Protozoan Infections: Where Are We Going Next? ( 30090098 )
2018
4
Intestinal helminths and protozoan infections in patients with colorectal cancer: prevalence and possible association with cancer pathogenesis. ( 30220046 )
2018
5
Artemisinin and its derivatives in treating protozoan infections beyond malaria. ( 27867026 )
2017
6
Epidemiology of Soil-Transmitted Helminth and Intestinal Protozoan Infections in Preschool-Aged Children in the Amhara Region of Ethiopia. ( 28167597 )
2017
7
The Roles of Mast Cells in Parasitic Protozoan Infections. ( 28428784 )
2017
8
The Mini-FLOTAC technique for the diagnosis of helminth and protozoan infections in humans and animals. ( 28771238 )
2017
9
Molecular Biology Can Change the Classic Laboratory Approach for Intestinal Protozoan Infections. ( 29163458 )
2017
10
Prevalence and Risk Factors for Intestinal Protozoan Infections with Cryptosporidium, Giardia, Blastocystis and Dientamoeba among Schoolchildren in Tripoli, Lebanon. ( 26974335 )
2016
11
Correction: Prevalence and Risk Factors for Intestinal Protozoan Infections with Cryptosporidium, Giardia, Blastocystis and Dientamoeba among Schoolchildren in Tripoli, Lebanon. ( 27081847 )
2016
12
Trends in prevalence of soil-transmitted helminth and major intestinal protozoan infections among school-aged children in Nepal. ( 27097973 )
2016
13
Prevalence and risk factors of intestinal protozoan infections: a population-based study in rural areas of Boyer-Ahmad district, Southwestern Iran. ( 27884121 )
2016
14
PREVALENCE OF INTESTINAL PROTOZOAN INFECTIONS AMONG CHILDREN IN THAILAND: A LARGE-SCALE SCREENING AND COMPARATIVE STUDY OF THREE STANDARD DETECTION METHODS. ( 29634157 )
2016
15
Protozoan infections in farmed fish from Brazil: diagnosis and pathogenesis. ( 25909248 )
2015
16
Prevalence of intestinal protozoan infections among individuals living with HIV/AIDS at Felegehiwot Referral Hospital, Bahir Dar, Ethiopia. ( 25917962 )
2015
17
To bet or not to bet: deciphering cell to cell variation in protozoan infections. ( 26070403 )
2015
18
A cross-sectional analysis of clinical presentations of and risk factors for enteric protozoan Infections in an Active Duty Population during Operation Iraqi Freedom. ( 28883934 )
2015
19
Recurrent wheezing is associated with intestinal protozoan infections in Warao Amerindian children in Venezuela: a cross-sectional survey. ( 24885094 )
2014
20
Marked antigiardial activity of Yucca baccata extracts: a potential natural alternative for treating protozoan infections. ( 25250335 )
2014
21
Epidemiology and geographical distribution of enteric protozoan infections in sydney, australia. ( 25343139 )
2014
22
The Regulation of CD4(+) T Cell Responses during Protozoan Infections. ( 25352846 )
2014
23
Comparison between Quantitative Buffy Coat (QBC) and Giemsa-stained Thin Film (GTF) technique for blood protozoan infections in wild rats. ( 25382468 )
2014
24
Breast-feeding protects infantile diarrhea caused by intestinal protozoan infections. ( 24327776 )
2013
25
Diagnosis of multiple enteric protozoan infections by enzyme-linked immunosorbent assay in the Guatemalan highlands. ( 23185076 )
2013
26
Intestinal protozoan infections in the immunocompromised host. ( 23806893 )
2013
27
Prevalence of intestinal protozoan infections among Orang Asli schoolchildren in Pos Senderut, Pahang, Malaysia. ( 24640856 )
2013
28
The epidemiology of soil-transmitted helminth and protozoan infections in south-west Cameroon. ( 21281528 )
2012
29
Macrophage migration inhibitory factor in protozoan infections. ( 22496958 )
2012
30
Giardia lamblia and respiratory allergies: a study of children from an urban area with a high incidence of protozoan infections. ( 22622669 )
2012
31
Protozoan infections of the gastrointestinal tract. ( 22632642 )
2012
32
Therapy of vector-borne protozoan infections in nonendemic settings. ( 21609269 )
2011
33
Current developments in the therapy of protozoan infections. ( 21629507 )
2011
34
Factors associated with high prevalence of intestinal protozoan infections among patients in Sana'a City, Yemen. ( 21789210 )
2011
35
Styrax japonica supplementation diet enhances the innate immune response in Epinephelus bruneus against bacterial and protozoan infections. ( 21824474 )
2011
36
Galectin-11 induction in the gastrointestinal tract of cattle following nematode and protozoan infections. ( 21958368 )
2011
37
Macrophage migration inhibitory factor (MIF): a key player in protozoan infections. ( 22110378 )
2011
38
Intestinal protozoan infections in relation to nutritional status and gastrointestinal morbidity in Colombian school children. ( 20061400 )
2010
39
Patterns of protozoan infections: spatiotemporal associations with cattle density. ( 20229128 )
2010
40
Validation of multiple diagnostic techniques to detect Cryptosporidium sp. and Giardia sp. in free-ranging western lowland gorillas (Gorilla gorilla gorilla) and observations on the prevalence of these protozoan infections in two populations in Gabon. ( 20597211 )
2010
41
Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug. ( 20837488 )
2010
42
Importance of nonenteric protozoan infections in immunocompromised people. ( 20930074 )
2010
43
Targeting caspases in intracellular protozoan infections. ( 18785049 )
2009
44
Treatment of intestinal protozoan infections in children. ( 19329448 )
2009
45
A survey of intestinal protozoan infections among gastroenteritis patients during a 3-year period (2004-2006) in Gyeonggi-do (province), South Korea. ( 19724707 )
2009
46
The incidence, intensity and host morbidity of human parasitic protozoan infections in gastrointestinal disorder outpatients in Buea Sub Division, Cameroon. ( 20130377 )
2009
47
Development of protease inhibitors for protozoan infections. ( 18978536 )
2008
48
Alternatively activated macrophages in protozoan infections. ( 17628461 )
2007
49
Epidemiology of parasitic protozoan infections in Soay sheep (Ovis aries L.) on St Kilda. ( 16978448 )
2007
50
Human waterborne trematode and protozoan infections. ( 17499101 )
2007

Variations for Parasitic Protozoa Infectious Disease

Expression for Parasitic Protozoa Infectious Disease

Search GEO for disease gene expression data for Parasitic Protozoa Infectious Disease.

Pathways for Parasitic Protozoa Infectious Disease

Pathways related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 HSPA4 ICAM1 IFNG IL10 IL2 IL4
2
Show member pathways
12.76 ICAM1 IFNG IL2 IL4 TLR9 TNF
3
Show member pathways
12.61 IFNG IL10 IL2 IL4 TNF
4
Show member pathways
12.56 IFNG IL10 IL2 IL4 TNF
5 12.53 IFNG IL10 IL2 IL4 TLR9 TNF
6
Show member pathways
12.49 ICAM1 IFNG IL2 IL4 TNF
7
Show member pathways
12.39 IFNG IL10 IL2 IL4 TNF
8
Show member pathways
12.35 IFNG IL10 IL2 IL4
9
Show member pathways
12.24 IFNG IL10 IL4 TNF
10
Show member pathways
12.24 ICAM1 IFNG IL2 IL4 TCN2 TNF
11
Show member pathways
12.23 IFNG IL10 IL2 IL4 TNF
12 12.22 IFNG IL10 TLR9 TNF
13
Show member pathways
12.19 IL10 IL2 TLR9 TNF
14
Show member pathways
12.16 IFNG IL4 TLR9 TNF
15
Show member pathways
12.05 ICAM1 IFNG IL10 IL2 IL4
16
Show member pathways
12.01 IFNG IL10 IL2 TLR9 TNF
17 11.96 ICAM1 IL10 IL4 TNF
18 11.95 ICAM1 IFNG IL2 IL4 TNF
19 11.92 IFNG IL10 IL2 IL4 TNF
20 11.84 IFNG IL10 TNF
21 11.81 ICAM1 IFNG TNF
22 11.79 ICAM1 IFNG IL2 IL4
23
Show member pathways
11.75 IFNG IL2 IL4 TNF
24 11.67 IFNG IL10 IL2 IL4 TNF
25
Show member pathways
11.65 ICAM1 IFNG IL2 TNF
26
Show member pathways
11.63 IFNG IL2 TNF
27 11.59 IFNG IL10 IL2 TLR9 TNF
28 11.53 IFNG IL2 TNF
29
Show member pathways
11.52 HSPA4 IFNG TNF
30 11.52 ICAM1 IL10 IL4 TNF
31 11.51 IFNG IL10 IL2 IL4 TNF
32 11.49 IFNG IL2 TNF
33 11.47 IFNG IL10 IL2 IL4
34 11.31 IFNG IL2 IL4
35 11.29 IFNG IL4 TNF
36 11.2 IL10 IL2 IL4 TNF
37 11.12 IFNG IL10 IL2 IL4
38 11.1 ICAM1 IFNG IL10 TLR9 TNF
39 10.89 ICAM1 TNF
40 10.82 IFNG IL10 IL2 IL4 TNF
41 10.79 ACKR1 ICAM1 IFNG IL10 TLR9 TNF

GO Terms for Parasitic Protozoa Infectious Disease

Cellular components related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ICAM1 IFNG IL10 IL2 IL4 KRT83
2 mitochondrial respiratory chain complex III GO:0005750 8.96 MT-CO1 MT-CYB

Biological processes related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.98 IFNG IL10 IL2 IL4 TNF
2 positive regulation of inflammatory response GO:0050729 9.79 IL2 TLR9 TNF
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 IFNG IL2 IL4
4 immune response GO:0006955 9.73 IFNG IL10 IL2 IL4 TLR9 TNF
5 cytokine-mediated signaling pathway GO:0019221 9.72 ICAM1 IL10 IL2 IL4 TNF
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.7 ICAM1 IFNG TNF
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IFNG TNF
8 regulation of regulatory T cell differentiation GO:0045589 9.63 IFNG IL2
9 negative regulation of growth of symbiont in host GO:0044130 9.63 IL10 TNF
10 positive regulation of B cell proliferation GO:0030890 9.63 IL2 IL4 TLR9
11 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL10 TNF
12 response to molecule of bacterial origin GO:0002237 9.62 IL10 TLR9
13 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.61 TLR9 TNF
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.61 ICAM1 IL10 IL4
15 positive regulation of isotype switching to IgG isotypes GO:0048304 9.6 IL2 IL4
16 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
17 negative regulation of interleukin-8 production GO:0032717 9.57 IL10 TLR9
18 positive regulation of MHC class II biosynthetic process GO:0045348 9.56 IL10 IL4
19 negative regulation of cytokine secretion involved in immune response GO:0002740 9.55 IL10 TNF
20 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.54 ICAM1 TNF
21 electron transport coupled proton transport GO:0015990 9.51 MT-CO1 MT-CYB
22 regulation of isotype switching GO:0045191 9.49 IL10 IL4
23 type 2 immune response GO:0042092 9.48 IL10 IL4
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IFNG TNF
25 receptor biosynthetic process GO:0032800 9.37 IL10 TNF
26 negative regulation of interleukin-6 production GO:0032715 9.33 IL10 TLR9 TNF
27 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 IFNG TNF
28 response to copper ion GO:0046688 8.8 ICAM1 MT-CO1 MT-CYB

Molecular functions related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL10 IL2 IL4 TNF

Sources for Parasitic Protozoa Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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