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MCID: PRS036
MIFTS: 42

Parasitic Protozoa Infectious Disease

Categories: Cancer diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Parasitic Protozoa Infectious Disease

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MalaCards integrated aliases for Parasitic Protozoa Infectious Disease:

Name: Parasitic Protozoa Infectious Disease 12 15
Protozoan Infections 43 71
Sarcomastigophora Infectious Disease 12
Mastigophora Infectious Disease 12

Classifications:

MalaCards categories:
Global: Infectious diseases Cancer diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:2789
MeSH 43 D011528
NCIt 49 C34953
SNOMED-CT 67 89933001 95896000
ICD10 32 B50-B64 B64
UMLS 71 C0033740
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Summaries for Parasitic Protozoa Infectious Disease

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Disease Ontology : 12 A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes.

MalaCards based summary : Parasitic Protozoa Infectious Disease, also known as protozoan infections, is related to cryptosporidiosis and leishmaniasis. An important gene associated with Parasitic Protozoa Infectious Disease is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. The drugs Albendazole and Quinine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and bone.

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Related Diseases for Parasitic Protozoa Infectious Disease

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Diseases related to Parasitic Protozoa Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 579)
# Related Disease Score Top Affiliating Genes
1 cryptosporidiosis 33.5 CD8A CD40LG CD4
2 leishmaniasis 33.4 TNF LMLN IL4 IL10
3 giardiasis 33.4 CD8A CD40LG CD4
4 trichomoniasis 33.4 TNF LMLN CD40LG CD4
5 amebiasis 33.4 TNF IL4 CD40LG CD4
6 coccidiosis 33.1 TNF SERPINA3 MT-CYB IL4 IL10 ICOSLG
7 malaria 33.1 TNF MT-CYB IL4 IL10 ICOSLG CD8A
8 toxoplasmosis 32.0 TNF IL4 IL10 CD40LG
9 acquired immunodeficiency syndrome 31.5 TNF IL10 CD40LG CD4 CCR6
10 dysentery 31.4 TNF IL10 CD40LG CD4 CCR6
11 visceral leishmaniasis 31.4 TNF LMLN IL4 IL10
12 parasitic helminthiasis infectious disease 31.3 TNF SIGLEC5 SERPINA3 IL4 IL10 ICOSLG
13 myocarditis 31.3 TNF IL4 IL10 CD40LG
14 chagas disease 31.2 TNF IL4 IL10 CD4
15 acute myocarditis 31.1 IL10 H2AC18 CD8A CD4
16 dermatitis 31.1 TNF IL4 IL10 CCR6
17 hypersensitivity reaction type iii disease 31.1 TNF SERPINA3 CD40LG CD4
18 urethritis 31.1 TNF CD40LG CD4
19 schistosomiasis 31.1 TNF IL4 IL10 CD40LG
20 salpingitis 31.1 TNF SIGLEC5 CD40LG
21 echinococcosis 31.1 TNF IL10 CD8A CD40LG
22 filarial elephantiasis 31.1 IL4 IL10 CD4
23 sleeping sickness 31.1 TXNDC15 PRODH LMLN IL10 H2AC18
24 pneumocystosis 31.0 TNF MT-CYB CD8A CD40LG CD4 CCR6
25 meningoencephalitis 31.0 TNF IL10 CD8A CD40LG CD4 CCR6
26 typhoid fever 31.0 TNF CD40LG CCR6
27 respiratory allergy 31.0 TNF IL4 IL10 ICOSLG CD8A CD4
28 prostatitis 31.0 TNF IL4 IL10
29 immune deficiency disease 30.9 TNF IL4 IL10 ICOSLG H2AC18 CD40LG
30 proteasome-associated autoinflammatory syndrome 1 30.9 TNF IL4 IL10
31 bacterial infectious disease 30.9 TNF SERPINA3 PRODH IL10 ICOSLG H2AC18
32 cyclosporiasis 30.8 SERPINA3 CD4
33 primary amebic meningoencephalitis 11.4
34 granulomatous amebic encephalitis 11.4
35 trypanosomiasis 11.4
36 balantidiasis 11.4
37 theileriasis 11.4
38 dientamoebiasis 11.4
39 babesiosis 11.4
40 protozoal dysentery 11.2
41 cork-handlers' disease 10.9 CD8A CD40LG CD4
42 syphilitic meningitis 10.9 CD8A CD40LG CD4
43 coccidioidomycosis 10.9 CD40LG CD4 CCR6
44 conjunctivitis 10.9 TNF IL4 IL10
45 spongiotic dermatitis 10.9 CD8A CD4 CCR6
46 early yaws 10.9 CD8A CD40LG CD4
47 chancroid 10.9 CD40LG CD4 CCR6
48 norwegian scabies 10.9 CD8A CD40LG CD4
49 tertiary syphilis 10.9 CD8A CD40LG CD4
50 autoimmune neuropathy 10.9 ICOSLG CD40LG CD4

Graphical network of the top 20 diseases related to Parasitic Protozoa Infectious Disease:



Diseases related to Parasitic Protozoa Infectious Disease
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Symptoms & Phenotypes for Parasitic Protozoa Infectious Disease

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Drugs & Therapeutics for Parasitic Protozoa Infectious Disease

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Drugs for Parasitic Protozoa Infectious Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
2
Quinine Approved Phase 3 130-95-0 8549 3034034
3
Artemether Approved Phase 3 71963-77-4 119380 68911
4
Amodiaquine Approved, Investigational Phase 3 86-42-0 2165
5
Lumefantrine Approved Phase 3 82186-77-4 6437380
6
Mefloquine Approved, Investigational Phase 3 53230-10-7 4046
7
Primaquine Approved Phase 3 90-34-6 4908
8
Piperaquine Experimental, Investigational Phase 3 4085-31-8 5079497
9
Dihydroartemisinin Experimental, Investigational Phase 3 71939-50-9 6918483
10 Anthelmintics Phase 3
11 Antimitotic Agents Phase 3
12 Neuromuscular Agents Phase 3
13 Red Cinchona Phase 3
14 Antiprotozoal Agents Phase 3
15 Artemisinins Phase 3
16 Artemisinine Phase 3
17 Antimalarials Phase 3
18 Artemether, Lumefantrine Drug Combination Phase 3
19
Nitazoxanide Approved, Investigational, Vet_approved Phase 1, Phase 2 55981-09-4 41684
20 Anti-Infective Agents Phase 1, Phase 2
21 Antiparasitic Agents Phase 1, Phase 2
22 Analgesics Phase 1, Phase 2
23 Analgesics, Non-Narcotic Phase 1, Phase 2
24 Anti-Inflammatory Agents Phase 1, Phase 2
25 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
26 Mesalamine Phase 1, Phase 2 89-57-6
27 Antirheumatic Agents Phase 1, Phase 2
28
Artesunate Approved, Investigational 88495-63-0 6917864 5464098
29 Antiviral Agents

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Double-Blind, Placebo-Controlled Trial of Albendazole in HIV-Positive Patients With Intestinal Microsporidiosis Completed NCT00002191 Phase 3 Albendazole
2 A Phase III, Randomised, Open Labelled, Active Controlled, Multi Centre, Superiority Trial of ArTiMistâ„¢ Versus Intravenous Quinine in Children With Severe or Complicated Falciparum Malaria, or Uncomplicated Falciparum Malaria With Gastrointestinal Complications. Completed NCT01258049 Phase 3 Artemether Sublingual Spray;Quinine
3 A Multi-centre, Open-label Randomised Trial to Assess the Efficacy, Safety and Tolerability of the Triple ACT Artemether-lumefantrine+Amodiaquine (AL+AQ) Compared to the ACT Artemether-lumefantrine (AL) in Uncomplicated Falciparum Malaria in Cambodia and Vietnam Recruiting NCT03355664 Phase 3 ACT;TACT
4 An Open Label Randomised Comparative Trial to Establish the Efficacy of 3 mg/kg ArTiMistâ„¢ When Compared to Intravenous Quinine in Children With Severe or Complicated Falciparum Malaria, or Uncomplicated Falciparum Malaria With Gastrointestinal Complications Completed NCT01047436 Phase 2 Quinine;Artemether
5 Role of Intestinal Protozoa and Helminths in the Course of Ulcerative Colitis Active, not recruiting NCT03441893 Phase 1, Phase 2 Nitazoxanide 500Mg Oral Tablet;Mesalazine 250Mg Tablet and nitazoxanide 500Mg Oral Tablet;Mesalazine 250Mg
6 Randomized, Double-blind, Placebo-controlled Sequential Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SCYX-7158 After Single Oral Ascending Doses in Healthy Male Volunteers Completed NCT01533961 Phase 1 SCYX-7158;Placebo
7 PCR in Blood Cultures of Individuals With Positive and Inconclusive Serology for Chagas' Disease Completed NCT00511589
8 A Pilot Study to Optimise Controlled Human Malaria Infections Using Plasmodium Falciparum Sporozoites Administered by Needle and Syringe Completed NCT01465048
9 Assessment of the Use of Fixed Doses of Artesunate Plus Amodiaquine Combination for the Home Management of Presumed Malaria in Malagasy Children Completed NCT00612547 Artesunate + Amodiaquine Fixed Dose Combination (CoArsucam)
10 Survey of Intestinal Protozoal Infections and Sexual Transmitted Diseases Among Targeted Cohorts Completed NCT00630162
11 Relative Efficacy of Two Regimens of Ante-helminthic Treatment Completed NCT00367627 Albendazole
12 Intestinal Helminths and Protozoan Infections in Patients With Colorectal Cancer: Prevalence and Possible Association With Cancer Pathogenesis Active, not recruiting NCT03173001

Search NIH Clinical Center for Parasitic Protozoa Infectious Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


acetyl sulfisoxazole
Aminoglycoside Antimicrobial [EPC]
Antiprotozoal [EPC]
Ciprofloxacin
Dihydrofolate Reductase Inhibitor Antimicrobial [EPC]
Dihydrofolate Reductase Inhibitor Antiprotozoal [EPC]
Eflornithine
Eflornithine Hydrochloride
ERYTHROMYCIN PWDR
gemifloxacin mesylate
Macrolide Antimicrobial [EPC]
Metronidazole
Metronidazole Hydrochloride
METRONIDAZOLE PWDR
nitazoxanide
Nitroimidazole Antimicrobial [EPC]
Pentamidine
Pentamidine Isethionate
Polyene Antimicrobial [EPC]
Sulfisoxazole
Sulfisoxazole Diolamine
Sulfonamide Antimicrobial [EPC]
Tetracycline-class Antimicrobial [EPC]
Tinidazole

Cochrane evidence based reviews: protozoan infections

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Genetic Tests for Parasitic Protozoa Infectious Disease

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Anatomical Context for Parasitic Protozoa Infectious Disease

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MalaCards organs/tissues related to Parasitic Protozoa Infectious Disease:

40
Lung, T Cells, Bone, Skin, B Cells, Thyroid, Prostate
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Publications for Parasitic Protozoa Infectious Disease

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Articles related to Parasitic Protozoa Infectious Disease:

(show top 50) (show all 579)
# Title Authors PMID Year
1
Bacterial and protozoan pathogens/symbionts in ticks infecting wild grasscutters Thryonomys swinderianus in Ghana. 61
32035054 2020
2
Organoids - New Models for Host-Helminth Interactions. 61
31791691 2020
3
Changes in the epidemiological profile of intestinal parasites after a school-based large-scale treatment for soil-transmitted helminths in a community in northeastern Brazil: Epidemiological profile after large-scale school-based treatment for STH. 61
31758913 2020
4
Prevalence and associated risk factors of human intestinal parasitic infections: a population-based study in the southeast of Kerman province, southeastern Iran. 61
31906872 2020
5
Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans. 61
31987839 2020
6
More Than Half Prevalence of Protozoan Parasitic Infections Among Diarrheic Outpatients in Eastern Tigrai, Ethiopia, 2019; A Cross-Sectional Study. 61
32021317 2020
7
First evidences of salt and pepper retinal lesions in patients with intestinal protozoan infections in Iran. 61
31903888 2020
8
Prevalence of selected intestinal protozoan infections in marginalized rural communities in Palestine. 61
31829156 2019
9
Mitochondrially-targeted treatment strategies. 61
31866004 2019
10
The zebrafish as a model for gastrointestinal tract-microbe interactions. 61
31872937 2019
11
Intestinal parasite infections and associated factors among inmates of Arba Minch prison, southern Ethiopia: cross sectional study. 61
31888496 2019
12
Gastrointestinal parasites in shelter cats of central Italy. 61
31796183 2019
13
Correlates of parasites and pseudoparasites in wolves (Canis lupus) across continents: A comparison among Yellowstone (USA), Abruzzo (IT) and Mercantour (FR) national parks. 61
31667082 2019
14
Gastrointestinal parasites as a possible threat to an endangered autochthonous Portuguese sheep breed. 61
31679528 2019
15
Unlocking the genetic basis of monarch butterflies' use of medicinal plants. 61
31713935 2019
16
Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors. 61
31663733 2019
17
Targeting parasite-produced MIF as an anti-virulence strategy with antibiotic-antibody combination to reduce tissue damage. 61
31677380 2019
18
Reduced prevalence of soil-transmitted helminths and high frequency of protozoan infections in the surrounding urban area of Curitiba, Paraná, Brazil. 61
31660444 2019
19
Microglia in neuropathology caused by protozoan parasites. 61
31682077 2019
20
Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections. 61
31640748 2019
21
Variable Surface Glycoprotein from Trypanosoma brucei Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach. 61
31597256 2019
22
Prevalence of intestinal parasitic infections in Hawassa University students' clinic, Southern Ethiopia: a 10-year retrospective study. 61
31661021 2019
23
Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules. 61
31199070 2019
24
A prevalence survey of enteral parasites in preschool children in the Mangochi District of Malawi. 61
31604429 2019
25
Increased Prevalence of Cestode Infection Associated with History of Deworming among Primary School Children in Ethiopia. 61
31333166 2019
26
HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes. 61
31311649 2019
27
Toxoplasma gondii infection in Amami spiny rat on Amami-Oshima Island, Japan. 61
31211046 2019
28
Infant growth faltering linked to subclinical mastitis, maternal faecal-oral contamination, and breastfeeding. 61
30472802 2019
29
Prevalence of feco-oral transmitted protozoan infections and associated factors among university students in Ethiopia: a cross-sectional study. 61
31174474 2019
30
Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis. 61
31216268 2019
31
The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis. 61
31211774 2019
32
Effects of single and integrated water, sanitation, handwashing, and nutrition interventions on child soil-transmitted helminth and Giardia infections: A cluster-randomized controlled trial in rural Kenya. 61
31242190 2019
33
Intravital microscopy: Imaging host-parasite interactions in the brain. 61
30830993 2019
34
The decrease of lasalocid residue in the edible tissues by silymarin supplementation of chicken diet. 61
30973080 2019
35
Parasite fauna of wild Antillean manatees (Trichechus manatus manatus) of the Andean Region, Colombia. 61
31029160 2019
36
Association of polymorphisms of the β-defensin 1 gene with nematode and protozoan infection traits in goat. 61
30582754 2019
37
Prevalence of Parasitic Intestinal Infections Among Food Handlers in Qazvin, Ä°ran 61
30938126 2019
38
Lophomonas blattarum Associated Broncho-Pulmonary Infection After Immunotherapy: A Case Report and A Smart-phone Based Video of Trophozoite 61
30938137 2019
39
Enteroparasitism and Risk Factors Associated with Clinical Manifestations in Children and Adults of Jalisco State in Western Mexico. 61
30847270 2019
40
Intestinal parasitic infections: Current status and associated risk factors among school aged children in an archetypal African urban slum in Nigeria. 61
28711437 2019
41
Editorial: Innovative Therapeutic and Immunomodulatory Strategies for Protozoan Infections. 61
31448246 2019
42
Immunodiagnostic potential of Wuchereria bancrofti L1 antigen-based filarial immunoglobulin G4 detection assay. 61
30321407 2019
43
Serological prevalence of toxoplasmosis and neosporosis in dogs diagnosed with suspected meningoencephalitis in the UK. 61
30371939 2019
44
Prevalence and diversity of gastrointestinal protozoa in Madura cattle at Bangkalan Regency, East Java, Indonesia. 61
31040558 2019
45
Innate Lymphoid Cells in Protection, Pathology, and Adaptive Immunity During Apicomplexan Infection. 61
30873151 2019
46
Aetiology of livestock fetal mortality in Mazandaran province, Iran. 61
30687586 2019
47
Bioactive Natural and Synthetic Peroxides for the Treatment of Helminth and Protozoan Pathogens: Synthesis and Properties. 61
31509099 2019
48
Intestinal helminths and protozoan infections in patients with colorectal cancer: prevalence and possible association with cancer pathogenesis. 61
30220046 2018
49
Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase. 61
30418024 2018
50
Hymenolepis nana-An Emerging Intestinal Parasite Associated with Anemia in School Children from the Bolivian Chaco. 61
30298806 2018
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Variations for Parasitic Protozoa Infectious Disease

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Expression for Parasitic Protozoa Infectious Disease

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Search GEO for disease gene expression data for Parasitic Protozoa Infectious Disease.
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Pathways for Parasitic Protozoa Infectious Disease

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Pathways related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 36
Show member pathways
 12.61 TNF IL4 IL10 ICOSLG CD8A CD40LG
2
Immune response NFAT in immune response 22
Show member pathways
 12.47 TNF IL4 IL10 ICOSLG CD40LG CD4
3
NF-kappaB Signaling 4
12.41 TNF IL4 IL10 CD8A CD40LG
4
T cell receptor signaling pathway 36
Show member pathways
 12.39 TNF IL4 IL10 CD8A CD40LG CD4
5
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.21 TNF IL10 CCR6 ACKR1
6
Toxoplasmosis 36
Show member pathways
 12.14 TNF IL4 IL10 CD40LG
7
Cell adhesion molecules (CAMs) 36
11.98 ICOSLG CD8A CD40LG CD4
8
Hematopoietic cell lineage 36
11.75 TNF IL4 CD8A CD4
9
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.65 TNF IL4 CD40LG
10
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.62 TNF IL4 IL10 CD8A CD4
11
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.61 TNF IL4 IL10
12
Dendritic Cells Developmental Lineage Pathway 64
11.57 TNF IL10 CD8A CD4
13
IL4-mediated signaling events 1
11.54 IL4 IL10 CD40LG
14
B Cell Development Pathways 64
11.45 IL10 CD40LG CD4
15
Interleukin-10 signaling 65
11.4 TNF IL4 IL10
16
Th2 Differentiation Pathway 64
11.36 IL4 IL10 CD4
17
Malaria 36
11.26 TNF IL10 CD40LG ACKR1
18
Primary immunodeficiency 36
11.23 CD8A CD40LG CD4
19
Innate Lymphoid Cell Differentiation Pathways 64
11 TNF IL4 IL10 CD8A CD4 CCR6
20
Cytokines and Inflammatory Response 1
10.72 TNF IL4 IL10 CD4
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GO Terms for Parasitic Protozoa Infectious Disease

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Cellular components related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 TNF ICOSLG CD8A CD40LG CD4 CCR6

Biological processes related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 TNF SERPINA3 IL10 CD40LG ACKR1
2 regulation of immune response GO:0050776 9.81 IL4 ICOSLG CD8A CD40LG
3 B cell differentiation GO:0030183 9.72 IL4 IL10 CD40LG
4 positive regulation of T cell proliferation GO:0042102 9.65 IL4 CD40LG CD4
5 defense response GO:0006952 9.62 TNF ICOSLG DEFB130A ACKR1
6 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL4 IL10
7 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.52 IL4 IL10
8 immune response GO:0006955 9.5 TNF IL4 IL10 CD8A CD40LG CD4
9 endothelial cell apoptotic process GO:0072577 9.49 TNF IL10
10 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 TNF IL10
11 regulation of immunoglobulin secretion GO:0051023 9.4 TNF CD40LG
12 type 2 immune response GO:0042092 9.37 IL4 IL10
13 regulation of isotype switching GO:0045191 9.26 IL4 IL10
14 receptor biosynthetic process GO:0032800 9.16 TNF IL10
15 T cell activation GO:0042110 8.92 IL4 ICOSLG CD8A CD4

Molecular functions related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL4 IL10 CD40LG
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Sources for Parasitic Protozoa Infectious Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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