MCID: PRS036
MIFTS: 44

Parasitic Protozoa Infectious Disease

Categories: Cancer diseases, Infectious diseases

Aliases & Classifications for Parasitic Protozoa Infectious Disease

MalaCards integrated aliases for Parasitic Protozoa Infectious Disease:

Name: Parasitic Protozoa Infectious Disease 12 15
Protozoan Infections 44 71
Sarcomastigophora Infectious Disease 12
Mastigophora Infectious Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2789
MeSH 44 D011528
NCIt 50 C34953
SNOMED-CT 67 95896000
ICD10 32 B64
UMLS 71 C0033740

Summaries for Parasitic Protozoa Infectious Disease

Disease Ontology : 12 A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes.

MalaCards based summary : Parasitic Protozoa Infectious Disease, also known as protozoan infections, is related to babesiosis and giardiasis. An important gene associated with Parasitic Protozoa Infectious Disease is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Albendazole and Anthelmintics have been mentioned in the context of this disorder. Affiliated tissues include kidney, small intestine and skin, and related phenotype is integument.

Related Diseases for Parasitic Protozoa Infectious Disease

Diseases related to Parasitic Protozoa Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 797)
# Related Disease Score Top Affiliating Genes
1 babesiosis 32.8 MT-CYB IL10 CD4 ALB
2 giardiasis 32.8 IL10 CD8A CD4 ALB
3 amebiasis 32.8 TNF IL4 IL10 CD4 ALB
4 leishmaniasis 32.7 TNF LMLN IL6 IL4 IL2 IL10
5 trichomoniasis 32.7 TNF LMLN IL6 IL2 IL10 CD4
6 trypanosomiasis 32.7 TNF IL6 IL4 IL10 H2AC18 ALB
7 coccidiosis 32.4 TNF MT-CYB IL6 IL4 IL2 IL10
8 malaria 32.3 TNF SERPINA3 MT-CYB IL6 IL4 IL2
9 toxoplasmosis 31.6 TNF IL6 IL4 IL10 DHFR
10 cryptosporidiosis 31.4 DHFR CD8A CD4
11 diarrhea 31.2 TNF IL6 IL2 IL10 ALB
12 chagas disease 31.1 TNF IL6 IL4 IL2 IL10 CD4
13 dysentery 31.0 TNF IL6 IL10 H2AC18 CD4 CCR6
14 acquired immunodeficiency syndrome 31.0 TNF IL6 IL2 IL10 CD4 CCR6
15 parasitic helminthiasis infectious disease 30.9 TNF SIGLEC5 SERPINA3 IL6 IL4 IL2
16 myocarditis 30.9 TNF IL6 IL4 IL2 IL10
17 gastroenteritis 30.9 TNF IL6 IL4 IL10 ALB
18 acute myocarditis 30.8 TNF IL10 H2AC18 CD4
19 respiratory allergy 30.8 IL4 IL10 ICOSLG CD4 CCR6
20 echinococcosis 30.7 TNF IL6 IL10 CD8A
21 schistosomiasis 30.7 TNF IL4 IL2 IL10 ALB
22 sleeping sickness 30.7 PRODH LMLN IL6 IL10 H2AC18
23 typhoid fever 30.7 TNF SIGLEC5 IL6 CCR6 ALB
24 proteasome-associated autoinflammatory syndrome 1 30.7 TNF IL6 IL4 IL10 ALB
25 visceral leishmaniasis 30.7 TNF LMLN IL4 IL2 IL10 ALB
26 bacterial infectious disease 30.7 TNF SERPINA3 IL6 IL10 ICOSLG H2AC18
27 meningoencephalitis 30.6 TNF SERPINA3 IL6 IL10 CD8A CD4
28 pneumocystosis 30.6 TNF MT-CYB IL6 IL2 DHFR CD8A
29 colorectal cancer 30.2 TNF SERPINA3 MT-CYB IL6 IL4 IL2
30 primary amebic meningoencephalitis 11.3
31 granulomatous amebic encephalitis 11.3
32 balantidiasis 11.3
33 theileriasis 11.3
34 dientamoebiasis 11.3
35 elephantiasis 10.6 IL4 IL10 CD4
36 adult acute lymphocytic leukemia 10.6 CD8A CD4 CCR6
37 tropical endomyocardial fibrosis 10.6 TNF IL4 IL10
38 endomyocardial fibrosis 10.6 TNF IL4 IL10
39 enterocolitis 10.6 TNF IL6 IL10
40 cork-handlers' disease 10.6 CD8A CD4 ALB
41 esophageal candidiasis 10.6 CD8A CD4 CCR6
42 type 1 diabetes mellitus 23 10.6 TNF CD8A CD4
43 punctate inner choroidopathy 10.6 TNF IL10
44 subcutaneous mycosis 10.6 IL10 CD4 CCR6
45 oral hairy leukoplakia 10.6 IL10 CD8A CD4
46 cerebritis 10.6 TNF CD8A CD4
47 viral exanthem 10.6 TNF CD8A CD4
48 immunodeficiency 16 10.6 ICOSLG CD8A CD4 CCR6
49 loiasis 10.6 IL4 IL10 CD4
50 granulomatous dermatitis 10.6 TNF CD8A CD4

Graphical network of the top 20 diseases related to Parasitic Protozoa Infectious Disease:



Diseases related to Parasitic Protozoa Infectious Disease

Symptoms & Phenotypes for Parasitic Protozoa Infectious Disease

MGI Mouse Phenotypes related to Parasitic Protozoa Infectious Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.28 CD4 CD8A DHFR IL10 IL4 IL6

Drugs & Therapeutics for Parasitic Protozoa Infectious Disease

Drugs for Parasitic Protozoa Infectious Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
2 Anthelmintics Phase 3
3 Antimitotic Agents Phase 3
4 Tubulin Modulators Phase 3
5
Nitazoxanide Approved, Investigational, Vet_approved Phase 1, Phase 2 55981-09-4 41684
6 Anti-Infective Agents Phase 1, Phase 2
7 Antiparasitic Agents Phase 1, Phase 2
8 Mesalamine Phase 1, Phase 2 89-57-6
9 Anti-Inflammatory Agents Phase 1, Phase 2
10 Analgesics, Non-Narcotic Phase 1, Phase 2
11 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
12 Analgesics Phase 1, Phase 2
13 Antirheumatic Agents Phase 1, Phase 2
14
Artemether Approved Phase 1 71963-77-4 119380 9796294 68911
15
Lumefantrine Approved Phase 1 82186-77-4 6437380
16 Antiprotozoal Agents Phase 1
17 Antimalarials Phase 1
18 Vaccines Phase 1
19 Artemether, Lumefantrine Drug Combination Phase 1
20
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
21
tannic acid Approved 1401-55-4
22 Calcium, Dietary
23
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double-Blind, Placebo-Controlled Trial of Albendazole in HIV-Positive Patients With Intestinal Microsporidiosis Completed NCT00002191 Phase 3 Albendazole
2 Role of Intestinal Protozoa and Helminths in the Course of Ulcerative Colitis Active, not recruiting NCT03441893 Phase 1, Phase 2 Nitazoxanide 500Mg Oral Tablet;Mesalazine 250Mg Tablet and nitazoxanide 500Mg Oral Tablet;Mesalazine 250Mg
3 Randomized, Double-blind, Placebo-controlled Sequential Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SCYX-7158 After Single Oral Ascending Doses in Healthy Male Volunteers Completed NCT01533961 Phase 1 SCYX-7158;Placebo
4 A Single Centre, Open Label, Pilot Phase Ib Study to Investigate Blood Stage Malaria Infection After Direct Venous Inoculation of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites (PfSPZ-DVI) in Malaria naïve Healthy Adult Volunteers Recruiting NCT04310085 Phase 1 Artemether-Lumefantrine 20 Mg-120 Mg Oral Tablet
5 Survey of Intestinal Protozoal Infections and Sexual Transmitted Diseases Among Targeted Cohorts Completed NCT00630162
6 PCR in Blood Cultures of Individuals With Positive and Inconclusive Serology for Chagas' Disease Completed NCT00511589
7 Intestinal Helminths and Protozoan Infections in Patients With Colorectal Cancer: Prevalence and Possible Association With Cancer Pathogenesis Active, not recruiting NCT03173001
8 Effect on Pregnancy Outcomes, Infant Growth and Development of an Egg Intervention During Pregnancy in Indonesia Not yet recruiting NCT04694235

Search NIH Clinical Center for Parasitic Protozoa Infectious Disease

Inferred drug relations via UMLS 71 / NDF-RT 51 :


acetyl sulfisoxazole
Aminoglycoside Antimicrobial [EPC]
Antiprotozoal [EPC]
Ciprofloxacin
Dihydrofolate Reductase Inhibitor Antimicrobial [EPC]
Dihydrofolate Reductase Inhibitor Antiprotozoal [EPC]
Eflornithine
Eflornithine Hydrochloride
ERYTHROMYCIN PWDR
gemifloxacin mesylate
Macrolide Antimicrobial [EPC]
Metronidazole
Metronidazole Hydrochloride
METRONIDAZOLE PWDR
nitazoxanide
Nitroimidazole Antimicrobial [EPC]
Pentamidine
Pentamidine Isethionate
Polyene Antimicrobial [EPC]
Sulfisoxazole
Sulfisoxazole Diolamine
Sulfonamide Antimicrobial [EPC]
Tetracycline-class Antimicrobial [EPC]
Tinidazole

Cochrane evidence based reviews: protozoan infections

Genetic Tests for Parasitic Protozoa Infectious Disease

Anatomical Context for Parasitic Protozoa Infectious Disease

MalaCards organs/tissues related to Parasitic Protozoa Infectious Disease:

40
Kidney, Small Intestine, Skin, Nk Cells, T Cells, Brain, Retina

Publications for Parasitic Protozoa Infectious Disease

Articles related to Parasitic Protozoa Infectious Disease:

(show top 50) (show all 608)
# Title Authors PMID Year
1
Socio-demographic influences on the prevalence of intestinal parasitic infections among workers in Qatar. 61
33472686 2021
2
Detection and characterization of the Isospora lunaris infection from different finch hosts in southern Iran. 61
33179153 2021
3
The Stem Cell Revolution Revealing Protozoan Parasites' Secrets and Paving the Way towards Vaccine Development. 61
33572549 2021
4
Diagnosis of intestinal protozoan infections in patients in Cuba by microscopy and molecular methods: advantages and disadvantages. 61
33188802 2020
5
Protozoan infections are under-recognized in Swedish patients with gastrointestinal symptoms. 61
32638222 2020
6
Host-parasite interactions in vector-borne protozoan infections. 61
33147559 2020
7
Global prevalence of intestinal parasitic infections and associated risk factors in pregnant women: a systematic review and meta-analysis. 61
33007067 2020
8
Detection of Intravascular Hemolysis in Newborn Infants Using Urinary Carbonic Anhydrase I Immunoreactivity. 61
32529247 2020
9
Discovery of Amphamide, a Drug Candidate for the Second Generation of Polyene Antibiotics. 61
32598131 2020
10
Gastrointestinal parasites of dromedary camel (Camelus dromedarius) in Algeria. 61
33061238 2020
11
Targeting histone acetylation/deacetylation in parasites: an update (2017-2020). 61
32615359 2020
12
Leishmania Immunity: Advancing Immunotherapy and Vaccine Development. 61
32784615 2020
13
Antimicrobial peptides in human corneal tissue of patients with fungal keratitis. 61
32855162 2020
14
Alkyl and Aryl Derivatives Based on p-Coumaric Acid Modification and Inhibitory Action against Leishmania braziliensis and Plasmodium falciparum. 61
32664596 2020
15
Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance. 61
32692767 2020
16
Bacterial and protozoan pathogens/symbionts in ticks infecting wild grasscutters (Thryonomys swinderianus) in Ghana. 61
32035054 2020
17
Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans. 61
31987839 2020
18
Intestinal Protozoan Parasitic Infections in Immunocompromised Child Patients with Diarrhea. 61
31875601 2020
19
Molecular prevalence of intestinal parasites infections in children with diarrhea in Franceville, Southeast of Gabon. 61
32414337 2020
20
Intestinal protozoan infections among children 0-168 months with diarrhea in Mozambique: June 2014 - January 2018. 61
32320399 2020
21
Clearing or subverting the enemy: Role of autophagy in protozoan infections. 61
32088215 2020
22
Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis. 61
32302296 2020
23
Microglia in neuropathology caused by protozoan parasites. 61
31682077 2020
24
Prevalence of Intestinal Parasitic Infections among the Bulgarian Population Over a Three Year Period (2015 - 2017). 61
32063735 2020
25
Medication for COVID-19-an Overview of Approaches Currently Under Study. 61
32343658 2020
26
The zebrafish as a model for gastrointestinal tract-microbe interactions. 61
31872937 2020
27
Targeting Parasite-Produced Macrophage Migration Inhibitory Factor as an Antivirulence Strategy With Antibiotic-Antibody Combination to Reduce Tissue Damage. 61
31677380 2020
28
Mitochondrially-targeted treatment strategies. 61
31866004 2020
29
Organoids - New Models for Host-Helminth Interactions. 61
31791691 2020
30
Changes in the epidemiological profile of intestinal parasites after a school-based large-scale treatment for soil-transmitted helminths in a community in northeastern Brazil: Epidemiological profile after large-scale school-based treatment for STH. 61
31758913 2020
31
Update on the major imported protozoan infections in travelers and migrants. 61
32065535 2020
32
The Delay in the Licensing of Protozoal Vaccines: A Comparative History. 61
32210953 2020
33
Old Antiprotozoal Drugs: Are They Still Viable Options for Parasitic Infections or New Options for Other Diseases? 61
31264538 2020
34
Assessment of Prevalence and Risk Factors for Intestinal Parasitosis, Malnutrition, and Anemia among School Children in Ghindae Area, Eritrea. 61
33178289 2020
35
First evidences of salt and pepper retinal lesions in patients with intestinal protozoan infections in Iran. 61
31903888 2020
36
More Than Half Prevalence of Protozoan Parasitic Infections Among Diarrheic Outpatients in Eastern Tigrai, Ethiopia, 2019; A Cross-Sectional Study. 61
32021317 2020
37
Prevalence and associated risk factors of human intestinal parasitic infections: a population-based study in the southeast of Kerman province, southeastern Iran. 61
31906872 2020
38
Prevalence of Intestinal Parasitic Infections and Associated Water, Sanitation, and Hygiene Risk Factors among School Children in Mwea Irrigation Scheme, Kirinyaga County, Kenya. 61
32454837 2020
39
Gastrointestinal parasites in shelter cats of central Italy. 61
31796183 2019
40
Intestinal parasite infections and associated factors among inmates of Arba Minch prison, southern Ethiopia: cross sectional study. 61
31888496 2019
41
Correlates of parasites and pseudoparasites in wolves (Canis lupus) across continents: A comparison among Yellowstone (USA), Abruzzo (IT) and Mercantour (FR) national parks. 61
31667082 2019
42
Prevalence of selected intestinal protozoan infections in marginalized rural communities in Palestine. 61
31829156 2019
43
Reduced prevalence of soil-transmitted helminths and high frequency of protozoan infections in the surrounding urban area of Curitiba, Paraná, Brazil. 61
31660444 2019
44
Gastrointestinal parasites as a possible threat to an endangered autochthonous Portuguese sheep breed. 61
31679528 2019
45
Unlocking the genetic basis of monarch butterflies' use of medicinal plants. 61
31713935 2019
46
Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors. 61
31663733 2019
47
Prevalence of intestinal parasitic infections in Hawassa University students' clinic, Southern Ethiopia: a 10-year retrospective study. 61
31661021 2019
48
Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules. 61
31199070 2019
49
A prevalence survey of enteral parasites in preschool children in the Mangochi District of Malawi. 61
31604429 2019
50
Variable Surface Glycoprotein from Trypanosoma brucei Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach. 61
31597256 2019

Variations for Parasitic Protozoa Infectious Disease

Expression for Parasitic Protozoa Infectious Disease

Search GEO for disease gene expression data for Parasitic Protozoa Infectious Disease.

Pathways for Parasitic Protozoa Infectious Disease

Pathways related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 TNF IL6 IL4 IL2 IL10 CD4
2
Show member pathways
12.78 TNF IL6 IL4 IL2 IL10 ICOSLG
3
Show member pathways
12.6 TNF IL4 IL2 IL10 ICOSLG CD4
4
Show member pathways
12.57 TNF IL6 IL2 IL10 CD4
5
Show member pathways
12.57 TNF IL6 IL4 IL2 IL10 CD4
6
Show member pathways
12.56 TNF IL6 IL4 IL2 IL10 CD8A
7 12.55 TNF IL4 IL2 IL10 CD8A
8 12.31 TNF IL6 IL2 CD4
9
Show member pathways
12.31 TNF IL6 IL2 IL10 CCR6 ACKR1
10
Show member pathways
12.25 TNF IL6 IL4 IL2 IL10
11
Show member pathways
12.24 TNF SERPINA3 IL6 IL4 IL2 DHFR
12
Show member pathways
12.19 TNF IL6 IL2 IL10
13 12.02 TNF IL6 IL2 IL10 CD8A CD4
14 11.99 TNF IL6 IL4 IL2
15 11.95 TNF IL6 IL4 IL10
16
Show member pathways
11.94 IL4 IL2 CD8A CD4
17 11.9 TNF IL6 IL4 CD8A CD4
18 11.76 TNF IL6 IL4 IL2 IL10 CD8A
19
Show member pathways
11.74 TNF IL6 IL2 IL10 CD4
20 11.73 TNF IL6 IL10
21
Show member pathways
11.73 TNF IL4 IL2
22 11.67 TNF IL6 IL2 IL10 CD8A CD4
23
Show member pathways
11.64 TNF IL6 IL2
24 11.64 TNF IL6 IL4
25
Show member pathways
11.62 TNF IL2 CD8A
26 11.55 TNF IL6 IL10 ACKR1
27 11.55 TNF IL6 IL4 IL10 ICOSLG CCR6
28 11.53 TNF IL6 IL2
29 11.53 TNF IL6 IL4 IL10
30 11.49 IL4 IL2 IL10 CD4
31 11.4 TNF IL4 IL2 IL10 CD8A CD4
32 11.37 TNF IL6 IL10
33
Show member pathways
11.36 TNF IL2 IL10
34 11.34 TNF IL6 IL10
35 11.29 TNF IL6 IL4
36 11.27 TNF IL6 DHFR
37 11.17 IL4 IL2 IL10
38 10.56 TNF IL6 IL4 IL2 IL10 CD4

GO Terms for Parasitic Protozoa Infectious Disease

Cellular components related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 TNF ICOSLG CD8A CD4 CCR6

Biological processes related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to glucocorticoid GO:0051384 9.73 TNF IL6 IL10
2 humoral immune response GO:0006959 9.7 TNF IL6 CCR6
3 cytokine-mediated signaling pathway GO:0019221 9.63 TNF IL6 IL4 IL2 IL10 CD4
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.62 TNF IL6 IL4 IL2
5 negative regulation of T-helper 17 cell differentiation GO:2000320 9.58 IL4 IL2
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.58 IL4 IL2
7 positive regulation of JAK-STAT cascade GO:0046427 9.58 TNF IL6 IL10
8 negative regulation of lipid storage GO:0010888 9.57 TNF IL6
9 positive regulation of T cell proliferation GO:0042102 9.56 IL6 IL4 IL2 CD4
10 endothelial cell apoptotic process GO:0072577 9.55 TNF IL10
11 vascular endothelial growth factor production GO:0010573 9.54 TNF IL6
12 positive regulation of immunoglobulin production GO:0002639 9.54 IL6 IL2 IL10
13 positive regulation of mononuclear cell migration GO:0071677 9.51 TNF IL4
14 negative regulation of cytokine production involved in immune response GO:0002719 9.49 TNF IL10
15 type 2 immune response GO:0042092 9.48 IL4 IL10
16 positive regulation of plasma cell differentiation GO:1900100 9.46 IL2 IL10
17 regulation of isotype switching GO:0045191 9.43 IL4 IL10
18 T cell activation GO:0042110 9.26 IL4 ICOSLG CD8A CD4
19 immune response GO:0006955 9.23 TNF IL6 IL4 IL2 IL10 CD8A

Molecular functions related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 IL6 IL4 IL2 IL10
2 cytokine activity GO:0005125 9.02 TNF IL6 IL4 IL2 IL10

Sources for Parasitic Protozoa Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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