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MCID: PRS036
MIFTS: 40

Parasitic Protozoa Infectious Disease

Categories: Infectious diseases, Cancer diseases
Genes Related diseases Publications Pathways Drugs
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Aliases & Classifications for Parasitic Protozoa Infectious Disease

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MalaCards integrated aliases for Parasitic Protozoa Infectious Disease:

Name: Parasitic Protozoa Infectious Disease 12 15
Protozoan Infections 44 73
Sarcomastigophora Infectious Disease 12
Mastigophora Infectious Disease 12

Classifications:

MalaCards categories:
Global: Infectious diseases Cancer diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:2789
ICD10 33 B50-B64 B64
MeSH 44 D011528
NCIt 50 C34953
UMLS 73 C0033740
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Summaries for Parasitic Protozoa Infectious Disease

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Disease Ontology : 12 A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes.

MalaCards based summary : Parasitic Protozoa Infectious Disease, also known as protozoan infections, is related to trypanosomiasis and leishmaniasis. An important gene associated with Parasitic Protozoa Infectious Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Allograft rejection and IL-2 Pathway. Related phenotype is immune system.

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Related Diseases for Parasitic Protozoa Infectious Disease

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Diseases related to Parasitic Protozoa Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)
# Related Disease Score Top Affiliating Genes
1 trypanosomiasis 32.7 IFNG IL10 IL2 IL4 TLR9 TNF
2 leishmaniasis 32.7 IFNG IL10 IL4 LMLN TLR9 TNF
3 coccidiosis 32.0 CD40LG CD79A IFNG IL10 IL2 IL4
4 malaria 30.4 ACKR1 CD40LG IFNG IL10 IL2 IL4
5 punctate inner choroidopathy 11.3 IL10 TNF
6 selective igg deficiency disease 11.2 CD40LG CD79A
7 c1q nephropathy 11.2 CD40LG CD79A
8 ross river fever 11.2 CD40LG IL10
9 mycoplasmal pneumonia 11.2 IFNG IL4
10 meningovascular neurosyphilis 11.2 CD40LG CD79A
11 alpha chain disease 11.2 CD40LG CD79A
12 cryptosporidiosis 11.2
13 brill-zinsser disease 11.2 CD40LG CD79A
14 exudative glomerulonephritis 11.2 CD40LG CD79A
15 oral tuberculosis 11.2 IL2 TNF
16 cork-handlers' disease 11.2 CD40LG CD79A
17 central nervous system vasculitis 11.2 CD40LG TLR9 TNF
18 mucocutaneous leishmaniasis 11.2 IL10 TLR9 TNF
19 salpingo-oophoritis 11.2 CD40LG CD79A
20 tropical endomyocardial fibrosis 11.2 IL10 IL4 TNF
21 early yaws 11.2 CD40LG CD79A
22 ventilation pneumonitis 11.2 CD40LG CD79A
23 chronic interstitial cystitis 11.2 CD40LG CD79A
24 tungiasis 11.2 IL10 IL4 TNF
25 ocular toxoplasmosis 11.2 CD40LG CD79A TLR9
26 endomyocardial fibrosis 11.2 IL10 IL4 TNF
27 axillary adenitis 11.2 CD40LG CD79A
28 panuveitis 11.1 CD40LG IL10 TNF
29 cryofibrinogenemia 11.1 CD40LG CD79A
30 lacrimal apparatus disease 11.1 IL10 TLR9 TNF
31 churg-strauss syndrome 11.1 CD40LG IL10 TNF
32 hemorrhagic fever with renal syndrome 11.1 CD40LG IL10 TNF
33 phlebotomus fever 11.1 CD40LG CD79A MT-CYB
34 fasciolopsiasis 11.1 CD40LG TCN2
35 hyperlucent lung 11.1 IFNG IL10 IL4
36 autoimmune disease of urogenital tract 11.1 CD40LG CD79A TLR9
37 idiopathic neutropenia 11.1 CD40LG IL10 TNF
38 primary amebic meningoencephalitis 11.1
39 granulomatous amebic encephalitis 11.1
40 giardiasis 11.1
41 balantidiasis 11.1
42 trichomoniasis 11.1
43 theileriasis 11.1
44 amebiasis 11.1
45 dientamoebiasis 11.1
46 babesiosis 11.1
47 osteosclerotic myeloma 11.1 CD40LG CD79A TNF
48 myasthenic syndrome, congenital, 10 11.1 CD40LG MT-CO1 MT-CYB
49 baylisascariasis 11.1 IFNG IL10 IL4
50 congenital hypogammaglobulinemia 11.1 CD40LG CD79A IL4

Graphical network of the top 20 diseases related to Parasitic Protozoa Infectious Disease:



Diseases related to Parasitic Protozoa Infectious Disease
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Symptoms & Phenotypes for Parasitic Protozoa Infectious Disease

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MGI Mouse Phenotypes related to Parasitic Protozoa Infectious Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 ACKR1 CD40LG CD79A IFNG IL10 IL2
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Drugs & Therapeutics for Parasitic Protozoa Infectious Disease

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Search Clinical Trials , NIH Clinical Center for Parasitic Protozoa Infectious Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: protozoan infections

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Genetic Tests for Parasitic Protozoa Infectious Disease

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Anatomical Context for Parasitic Protozoa Infectious Disease

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Publications for Parasitic Protozoa Infectious Disease

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Articles related to Parasitic Protozoa Infectious Disease:

# Title Authors Year
1
Island-Wide Surveillance of Gastrointestinal Protozoan Infections on Fiji by Expanding Lymphatic Filariasis Transmission Assessment Surveys as an Access Platform. ( 29405101 )
2018
2
Human parasitic protozoan infection to infertility: a systematic review. ( 26573517 )
2015
3
Breast-feeding protects infantile diarrhea caused by intestinal protozoan infections. ( 24327776 )
2013
4
Alternatively activated macrophages in protozoan infections. ( 17628461 )
2007
5
Cryptosporidiosis and other intestinal protozoan infections in children less than one year of age in Mexico City. ( 17172373 )
2006
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Variations for Parasitic Protozoa Infectious Disease

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Expression for Parasitic Protozoa Infectious Disease

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Search GEO for disease gene expression data for Parasitic Protozoa Infectious Disease.
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Pathways for Parasitic Protozoa Infectious Disease

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Pathways related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 37
Show member pathways
 12.82 CD40LG IFNG IL10 IL2 IL4 TNF
2
IL-2 Pathway 64
Show member pathways
 12.75 CD79A IFNG IL2 IL4 TLR9 TNF
3
Influenza A 37
Show member pathways
 12.74 IFNG IL2 IL4 TLR9 TNF
4
Regulation of IFNA signaling 66
Show member pathways
 12.59 IFNG IL10 IL2 IL4 TNF
5
Th17 cell differentiation 37
Show member pathways
 12.39 IFNG IL10 IL2 IL4 TNF
6
T cell receptor signaling pathway 37
Show member pathways
 12.38 CD40LG IFNG IL10 IL2 IL4 TNF
7
Folate Metabolism 1
Show member pathways
 12.29 IFNG IL2 IL4 TCN2 TNF
8
NF-kappaB Signaling 4
12.27 CD40LG CD79A IFNG IL10 IL2 IL4
9
Th1 Differentiation Pathway 65
Show member pathways
 12.22 IFNG IL10 IL2 TLR9 TNF
10
Toxoplasmosis 37
Show member pathways
 12.21 CD40LG IFNG IL10 IL4 TNF
11
Tuberculosis 37
12.19 IFNG IL10 TLR9 TNF
12
C-type lectin receptor signaling pathway 37
Show member pathways
 12.17 IL10 IL2 TLR9 TNF
13
Bacterial infections in CF airways 22
Show member pathways
 12.14 IFNG IL4 TLR9 TNF
14
Spinal Cord Injury 1
11.96 IFNG IL2 IL4 TNF
15
Amoebiasis 37
11.82 IFNG IL10 TNF
16
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.8 CD79A IFNG IL10 IL2 IL4 TNF
17
Glucocorticoid receptor regulatory network 1
11.74 IFNG IL2 IL4
18
Innate Lymphoid Cell Differentiation Pathways 65
11.71 IFNG IL10 IL2 IL4 TNF
19
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.65 CD40LG IFNG IL2 IL4 TNF
20
IL4-mediated signaling events 1
11.62 CD40LG IL10 IL4
21
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.62 CD40LG IFNG IL2 TNF
22
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.6 IFNG IL2 TNF
23
Dendritic Cells Developmental Lineage Pathway 65
11.59 IFNG IL10 IL2 TLR9 TNF
24
Photodynamic therapy-induced AP-1 survival signaling. 1
11.51 IFNG IL2 TNF
25
Interleukin-10 signaling 66
11.48 IL10 IL4 TNF
26
Aryl Hydrocarbon Receptor Pathway 1
11.47 IFNG IL2 TNF
27
Th2 Differentiation Pathway 65
11.47 IFNG IL10 IL2 IL4
28
African trypanosomiasis 37
11.32 IFNG IL10 TLR9 TNF
29
Inflammatory Response Pathway 1
11.28 CD40LG IFNG IL2 IL4
30
Development and heterogeneity of the ILC family 1
11.26 IFNG IL4 TNF
31
OX40 Pathway 64
11.15 IFNG IL10 IL2 IL4
32
Cytokines and Inflammatory Response 1
10.83 IFNG IL10 IL2 IL4 TNF
33
Malaria 37
10.79 ACKR1 CD40LG IFNG IL10 TLR9 TNF
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GO Terms for Parasitic Protozoa Infectious Disease

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Cellular components related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CD40LG IFNG IL10 IL2 IL4 SPINK5
2 extracellular space GO:0005615 9.28 CD40LG IFNG IL10 IL2 IL4 KRT83
3 mitochondrial respiratory chain complex III GO:0005750 9.16 MT-CO1 MT-CYB

Biological processes related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.97 ACKR1 CD40LG IL10 TLR9 TNF
2 immune response GO:0006955 9.85 CD40LG IFNG IL10 IL2 IL4 TNF
3 positive regulation of T cell proliferation GO:0042102 9.76 CD40LG IL2 IL4
4 positive regulation of B cell proliferation GO:0030890 9.69 IL2 IL4 TLR9
5 response to molecule of bacterial origin GO:0002237 9.61 IL10 TLR9
6 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.6 IL2 IL4
8 endothelial cell apoptotic process GO:0072577 9.59 IL10 TNF
9 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL10 IL4
10 B cell proliferation GO:0042100 9.58 CD40LG CD79A IL10
11 negative regulation of cytokine secretion involved in immune response GO:0002740 9.56 IL10 TNF
12 type 2 immune response GO:0042092 9.55 IL10 IL4
13 negative regulation of interleukin-8 production GO:0032717 9.54 IL10 TLR9
14 regulation of immunoglobulin secretion GO:0051023 9.52 CD40LG TNF
15 negative regulation of interleukin-6 production GO:0032715 9.5 IL10 TLR9 TNF
16 regulation of isotype switching GO:0045191 9.49 IL10 IL4
17 electron transport coupled proton transport GO:0015990 9.48 MT-CO1 MT-CYB
18 receptor biosynthetic process GO:0032800 9.46 IL10 TNF
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG TNF
20 regulation of signaling receptor activity GO:0010469 9.43 CD40LG IFNG IL10 IL2 IL4 TNF
21 positive regulation of interleukin-12 production GO:0032735 9.33 CD40LG IFNG TLR9
22 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 IFNG TNF
23 B cell differentiation GO:0030183 8.92 CD40LG CD79A IL10 IL4

Molecular functions related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CD40LG IFNG IL10 IL2 IL4 TNF
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Sources for Parasitic Protozoa Infectious Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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