MCID: PRS036
MIFTS: 43

Parasitic Protozoa Infectious Disease

Categories: Cancer diseases, Infectious diseases

Aliases & Classifications for Parasitic Protozoa Infectious Disease

MalaCards integrated aliases for Parasitic Protozoa Infectious Disease:

Name: Parasitic Protozoa Infectious Disease 12 15
Protozoan Infections 43 71
Sarcomastigophora Infectious Disease 12
Mastigophora Infectious Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2789
MeSH 43 D011528
NCIt 49 C34953
SNOMED-CT 67 95896000
ICD10 32 B64
UMLS 71 C0033740

Summaries for Parasitic Protozoa Infectious Disease

Disease Ontology : 12 A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes.

MalaCards based summary : Parasitic Protozoa Infectious Disease, also known as protozoan infections, is related to cryptosporidiosis and leishmaniasis. An important gene associated with Parasitic Protozoa Infectious Disease is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. The drugs Amodiaquine and Primaquine have been mentioned in the context of this disorder. Affiliated tissues include t cells, liver and kidney, and related phenotype is integument.

Related Diseases for Parasitic Protozoa Infectious Disease

Diseases related to Parasitic Protozoa Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 626)
# Related Disease Score Top Affiliating Genes
1 cryptosporidiosis 33.5 DHFR CD8A CD40LG CD4
2 leishmaniasis 33.4 TNF LMLN IL4 IL10
3 babesiosis 33.4 MT-CYB CD40LG CD4
4 trichomoniasis 33.4 TNF LMLN CD40LG CD4
5 giardiasis 33.4 CD8A CD40LG CD4
6 amebiasis 33.4 TNF IL4 CD40LG CD4
7 coccidiosis 33.2 TNF MT-CYB IL4 IL10 ICOSLG H2AC18
8 malaria 33.0 TNF SERPINA3 NANP MT-CYB IL4 IL10
9 toxoplasmosis 31.9 TNF IL4 IL10 DHFR CD40LG
10 acquired immunodeficiency syndrome 31.5 TNF IL10 CD40LG CD4 CCR6
11 dysentery 31.4 TNF IL10 H2AC18 CD40LG CD4 CCR6
12 visceral leishmaniasis 31.4 TNF LMLN IL4 IL10
13 parasitic helminthiasis infectious disease 31.4 TNF SIGLEC5 SERPINA3 IL4 IL10 ICOSLG
14 chagas disease 31.4 TNF IL4 IL10 CD4
15 myocarditis 31.3 TNF IL4 IL10 CD40LG
16 vasculitis 31.1 TNF SERPINA3 IL10 CD40LG
17 encephalitis 31.1 TNF IL4 IL10 CD40LG
18 schistosomiasis 31.1 TNF IL4 IL10 CD40LG
19 acute myocarditis 31.1 TNF IL10 H2AC18 CD4
20 dermatitis 31.1 TNF IL4 IL10 CCR6
21 hypersensitivity reaction type iii disease 31.1 TNF SERPINA3 ICOSLG CD40LG CCR6
22 salpingitis 31.1 TNF SIGLEC5 CD40LG CD4
23 urethritis 31.1 TNF CD40LG CD4
24 echinococcosis 31.1 TNF IL10 CD8A CD40LG
25 typhoid fever 31.1 TNF SIGLEC5 CD40LG CCR6
26 filarial elephantiasis 31.1 IL4 IL10 CD4
27 sleeping sickness 31.1 TXNDC15 PRODH LMLN IL10 H2AC18
28 respiratory allergy 31.0 TNF IL4 IL10 ICOSLG CD8A CD4
29 pneumocystosis 31.0 TNF MT-CYB DHFR CD8A CD40LG CD4
30 prostatitis 31.0 TNF SERPINA3 IL10
31 meningoencephalitis 31.0 TNF SERPINA3 IL4 IL10 CD8A CD40LG
32 immune deficiency disease 30.9 TNF SERPINA3 IL4 IL10 ICOSLG H2AC18
33 bacterial infectious disease 30.9 TNF SERPINA3 PRODH IL10 ICOSLG H2AC18
34 proteasome-associated autoinflammatory syndrome 1 30.9 TNF IL4 IL10
35 primary amebic meningoencephalitis 11.4
36 granulomatous amebic encephalitis 11.4
37 trypanosomiasis 11.4
38 balantidiasis 11.4
39 theileriasis 11.4
40 dientamoebiasis 11.4
41 protozoal dysentery 11.2
42 cork-handlers' disease 10.9 CD8A CD40LG CD4
43 conjunctivitis 10.9 TNF IL4 IL10
44 scabies 10.9 IL10 CD4 CCR6
45 early yaws 10.9 CD8A CD40LG CD4
46 autoimmune peripheral neuropathy 10.9 ICOSLG CD40LG CD4
47 chancroid 10.9 CD40LG CD4 CCR6
48 norwegian scabies 10.9 CD8A CD40LG CD4
49 anogenital venereal wart 10.9 H2AC18 CD8A CD4 CCR6
50 diabetes mellitus, insulin-dependent, 23 10.9 TNF CD8A CD4

Graphical network of the top 20 diseases related to Parasitic Protozoa Infectious Disease:



Diseases related to Parasitic Protozoa Infectious Disease

Symptoms & Phenotypes for Parasitic Protozoa Infectious Disease

MGI Mouse Phenotypes related to Parasitic Protozoa Infectious Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.32 CD4 CD40LG CD8A DHFR EPRS1 IL10

Drugs & Therapeutics for Parasitic Protozoa Infectious Disease

Drugs for Parasitic Protozoa Infectious Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amodiaquine Approved, Investigational Phase 3 86-42-0 2165
2
Primaquine Approved Phase 3 90-34-6 4908
3
Mefloquine Approved, Investigational Phase 3 53230-10-7 4046
4
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
5
Quinine Approved Phase 3 130-95-0 8549 3034034
6
Piperaquine Experimental, Investigational Phase 3 4085-31-8 5079497
7
Dihydroartemisinin Experimental, Investigational Phase 3 71939-50-9 6918483
8 Artemisinins Phase 3
9 Artemisinine Phase 3
10 Anthelmintics Phase 3
11 Tubulin Modulators Phase 3
12 Antimitotic Agents Phase 3
13 Red Cinchona Phase 3
14
Nitazoxanide Approved, Investigational, Vet_approved Phase 1, Phase 2 55981-09-4 41684
15 Anti-Infective Agents Phase 1, Phase 2
16 Antiparasitic Agents Phase 1, Phase 2
17 Analgesics, Non-Narcotic Phase 1, Phase 2
18 Analgesics Phase 1, Phase 2
19 Mesalamine Phase 1, Phase 2 89-57-6
20 Anti-Inflammatory Agents Phase 1, Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
22 Antirheumatic Agents Phase 1, Phase 2
23
Artemether Approved Phase 1 71963-77-4 68911 9796294 119380
24
Lumefantrine Approved Phase 1 82186-77-4 6437380
25 Antiprotozoal Agents Phase 1
26 Antimalarials Phase 1
27 Artemether, Lumefantrine Drug Combination Phase 1
28 Vaccines Phase 1
29
Artesunate Approved, Investigational 88495-63-0 6917864 5464098
30 Antiviral Agents

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Multi-centre, Open-label Randomised Trial to Assess the Efficacy, Safety and Tolerability of the Triple ACT Artemether-lumefantrine+Amodiaquine (AL+AQ) Compared to the ACT Artemether-lumefantrine (AL) in Uncomplicated Falciparum Malaria in Cambodia and Vietnam Unknown status NCT03355664 Phase 3 ACT;TACT
2 A Double-Blind, Placebo-Controlled Trial of Albendazole in HIV-Positive Patients With Intestinal Microsporidiosis Completed NCT00002191 Phase 3 Albendazole
3 A Phase III, Randomised, Open Labelled, Active Controlled, Multi Centre, Superiority Trial of ArTiMist™ Versus Intravenous Quinine in Children With Severe or Complicated Falciparum Malaria, or Uncomplicated Falciparum Malaria With Gastrointestinal Complications. Completed NCT01258049 Phase 3 Artemether Sublingual Spray;Quinine
4 An Open Label Randomised Comparative Trial to Establish the Efficacy of 3 mg/kg ArTiMist™ When Compared to Intravenous Quinine in Children With Severe or Complicated Falciparum Malaria, or Uncomplicated Falciparum Malaria With Gastrointestinal Complications Completed NCT01047436 Phase 2 Quinine;Artemether
5 Role of Intestinal Protozoa and Helminths in the Course of Ulcerative Colitis Active, not recruiting NCT03441893 Phase 1, Phase 2 Nitazoxanide 500Mg Oral Tablet;Mesalazine 250Mg Tablet and nitazoxanide 500Mg Oral Tablet;Mesalazine 250Mg
6 Randomized, Double-blind, Placebo-controlled Sequential Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SCYX-7158 After Single Oral Ascending Doses in Healthy Male Volunteers Completed NCT01533961 Phase 1 SCYX-7158;Placebo
7 A Single Centre, Open Label, Pilot Phase Ib Study to Investigate Blood Stage Malaria Infection After Direct Venous Inoculation of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites (PfSPZ-DVI) in Malaria naïve Healthy Adult Volunteers Recruiting NCT04310085 Phase 1 Artemether-Lumefantrine 20 Mg-120 Mg Oral Tablet
8 PCR in Blood Cultures of Individuals With Positive and Inconclusive Serology for Chagas' Disease Completed NCT00511589
9 Assessment of the Use of Fixed Doses of Artesunate Plus Amodiaquine Combination for the Home Management of Presumed Malaria in Malagasy Children Completed NCT00612547 Artesunate + Amodiaquine Fixed Dose Combination (CoArsucam)
10 A Pilot Study to Optimise Controlled Human Malaria Infections Using Plasmodium Falciparum Sporozoites Administered by Needle and Syringe Completed NCT01465048
11 Survey of Intestinal Protozoal Infections and Sexual Transmitted Diseases Among Targeted Cohorts Completed NCT00630162
12 Relative Efficacy of Two Regimens of Ante-helminthic Treatment Completed NCT00367627 Albendazole
13 Intestinal Helminths and Protozoan Infections in Patients With Colorectal Cancer: Prevalence and Possible Association With Cancer Pathogenesis Active, not recruiting NCT03173001

Search NIH Clinical Center for Parasitic Protozoa Infectious Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


acetyl sulfisoxazole
Aminoglycoside Antimicrobial [EPC]
Antiprotozoal [EPC]
Ciprofloxacin
Dihydrofolate Reductase Inhibitor Antimicrobial [EPC]
Dihydrofolate Reductase Inhibitor Antiprotozoal [EPC]
Eflornithine
Eflornithine Hydrochloride
ERYTHROMYCIN PWDR
gemifloxacin mesylate
Macrolide Antimicrobial [EPC]
Metronidazole
Metronidazole Hydrochloride
METRONIDAZOLE PWDR
nitazoxanide
Nitroimidazole Antimicrobial [EPC]
Pentamidine
Pentamidine Isethionate
Polyene Antimicrobial [EPC]
Sulfisoxazole
Sulfisoxazole Diolamine
Sulfonamide Antimicrobial [EPC]
Tetracycline-class Antimicrobial [EPC]
Tinidazole

Cochrane evidence based reviews: protozoan infections

Genetic Tests for Parasitic Protozoa Infectious Disease

Anatomical Context for Parasitic Protozoa Infectious Disease

MalaCards organs/tissues related to Parasitic Protozoa Infectious Disease:

40
T Cells, Liver, Kidney, Testes, Nk Cells, Brain, Small Intestine

Publications for Parasitic Protozoa Infectious Disease

Articles related to Parasitic Protozoa Infectious Disease:

(show top 50) (show all 590)
# Title Authors PMID Year
1
Detection of Intravascular Hemolysis in Newborn Infants Using Urinary Carbonic Anhydrase I Immunoreactivity. 61
32529247 2020
2
Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans. 61
31987839 2020
3
Bacterial and protozoan pathogens/symbionts in ticks infecting wild grasscutters (Thryonomys swinderianus) in Ghana. 61
32035054 2020
4
Intestinal Protozoan Parasitic Infections in Immunocompromised Child Patients with Diarrhea. 61
31875601 2020
5
Molecular prevalence of intestinal parasites infections in children with diarrhea in Franceville, Southeast of Gabon. 61
32414337 2020
6
Intestinal protozoan infections among children 0-168 months with diarrhea in Mozambique: June 2014 - January 2018. 61
32320399 2020
7
Clearing or subverting the enemy: Role of autophagy in protozoan infections. 61
32088215 2020
8
Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis. 61
32302296 2020
9
Microglia in neuropathology caused by protozoan parasites. 61
31682077 2020
10
Prevalence of Intestinal Parasitic Infections among the Bulgarian Population Over a Three Year Period (2015 - 2017). 61
32063735 2020
11
Medication for COVID-19-an Overview of Approaches Currently Under Study. 61
32343658 2020
12
The zebrafish as a model for gastrointestinal tract-microbe interactions. 61
31872937 2020
13
Targeting Parasite-Produced Macrophage Migration Inhibitory Factor as an Antivirulence Strategy With Antibiotic-Antibody Combination to Reduce Tissue Damage. 61
31677380 2020
14
Organoids - New Models for Host-Helminth Interactions. 61
31791691 2020
15
Mitochondrially-targeted treatment strategies. 61
31866004 2020
16
Changes in the epidemiological profile of intestinal parasites after a school-based large-scale treatment for soil-transmitted helminths in a community in northeastern Brazil: Epidemiological profile after large-scale school-based treatment for STH. 61
31758913 2020
17
Update on the major imported protozoan infections in travelers and migrants. 61
32065535 2020
18
The Delay in the Licensing of Protozoal Vaccines: A Comparative History. 61
32210953 2020
19
First evidences of salt and pepper retinal lesions in patients with intestinal protozoan infections in Iran. 61
31903888 2020
20
Prevalence and associated risk factors of human intestinal parasitic infections: a population-based study in the southeast of Kerman province, southeastern Iran. 61
31906872 2020
21
Prevalence of Intestinal Parasitic Infections and Associated Water, Sanitation, and Hygiene Risk Factors among School Children in Mwea Irrigation Scheme, Kirinyaga County, Kenya. 61
32454837 2020
22
More Than Half Prevalence of Protozoan Parasitic Infections Among Diarrheic Outpatients in Eastern Tigrai, Ethiopia, 2019; A Cross-Sectional Study. 61
32021317 2020
23
Intestinal parasite infections and associated factors among inmates of Arba Minch prison, southern Ethiopia: cross sectional study. 61
31888496 2019
24
Gastrointestinal parasites in shelter cats of central Italy. 61
31796183 2019
25
Correlates of parasites and pseudoparasites in wolves (Canis lupus) across continents: A comparison among Yellowstone (USA), Abruzzo (IT) and Mercantour (FR) national parks. 61
31667082 2019
26
Prevalence of selected intestinal protozoan infections in marginalized rural communities in Palestine. 61
31829156 2019
27
Gastrointestinal parasites as a possible threat to an endangered autochthonous Portuguese sheep breed. 61
31679528 2019
28
Unlocking the genetic basis of monarch butterflies' use of medicinal plants. 61
31713935 2019
29
Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors. 61
31663733 2019
30
Reduced prevalence of soil-transmitted helminths and high frequency of protozoan infections in the surrounding urban area of Curitiba, Paraná, Brazil. 61
31660444 2019
31
Prevalence of intestinal parasitic infections in Hawassa University students' clinic, Southern Ethiopia: a 10-year retrospective study. 61
31661021 2019
32
A prevalence survey of enteral parasites in preschool children in the Mangochi District of Malawi. 61
31604429 2019
33
Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules. 61
31199070 2019
34
Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections. 61
31640748 2019
35
Variable Surface Glycoprotein from Trypanosoma brucei Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach. 61
31597256 2019
36
HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes. 61
31311649 2019
37
Increased Prevalence of Cestode Infection Associated with History of Deworming among Primary School Children in Ethiopia. 61
31333166 2019
38
Toxoplasma gondii infection in Amami spiny rat on Amami-Oshima Island, Japan. 61
31211046 2019
39
Infant growth faltering linked to subclinical mastitis, maternal faecal-oral contamination, and breastfeeding. 61
30472802 2019
40
Prevalence of feco-oral transmitted protozoan infections and associated factors among university students in Ethiopia: a cross-sectional study. 61
31174474 2019
41
Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis. 61
31216268 2019
42
The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis. 61
31211774 2019
43
Effects of single and integrated water, sanitation, handwashing, and nutrition interventions on child soil-transmitted helminth and Giardia infections: A cluster-randomized controlled trial in rural Kenya. 61
31242190 2019
44
Intravital microscopy: Imaging host-parasite interactions in the brain. 61
30830993 2019
45
The decrease of lasalocid residue in the edible tissues by silymarin supplementation of chicken diet. 61
30973080 2019
46
Association of polymorphisms of the β-defensin 1 gene with nematode and protozoan infection traits in goat. 61
30582754 2019
47
Parasite fauna of wild Antillean manatees (Trichechus manatus manatus) of the Andean Region, Colombia. 61
31029160 2019
48
Lophomonas blattarum Associated Broncho-Pulmonary Infection After Immunotherapy: A Case Report and A Smart-phone Based Video of Trophozoite 61
30938137 2019
49
Prevalence of Parasitic Intestinal Infections Among Food Handlers in Qazvin, İran 61
30938126 2019
50
Enteroparasitism and Risk Factors Associated with Clinical Manifestations in Children and Adults of Jalisco State in Western Mexico. 61
30847270 2019

Variations for Parasitic Protozoa Infectious Disease

Expression for Parasitic Protozoa Infectious Disease

Search GEO for disease gene expression data for Parasitic Protozoa Infectious Disease.

Pathways for Parasitic Protozoa Infectious Disease

Pathways related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 TNF IL4 IL10 ICOSLG CD8A CD40LG
2
Show member pathways
12.47 TNF IL4 IL10 ICOSLG CD40LG CD4
3 12.41 TNF IL4 IL10 CD8A CD40LG
4
Show member pathways
12.39 TNF IL4 IL10 CD8A CD40LG CD4
5
Show member pathways
12.21 TNF IL10 CCR6 ACKR1
6
Show member pathways
12.2 TNF SERPINA3 IL4 DHFR
7
Show member pathways
12.13 TNF IL4 IL10 CD40LG
8 11.98 ICOSLG CD8A CD40LG CD4
9 11.75 TNF IL4 CD8A CD4
10
Show member pathways
11.64 TNF IL4 CD40LG
11 11.62 TNF IL4 IL10 CD8A CD4
12 11.57 TNF IL10 CD8A CD4
13 11.53 IL4 IL10 CD40LG
14 11.4 TNF IL4 IL10
15 11.36 IL4 IL10 CD4
16 11.26 TNF IL10 CD40LG ACKR1
17 11.23 CD8A CD40LG CD4
18 11 TNF IL4 IL10 CD8A CD4 CCR6
19 10.72 TNF IL4 IL10 CD4

GO Terms for Parasitic Protozoa Infectious Disease

Cellular components related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 TNF ICOSLG CD8A CD40LG CD4 CCR6

Biological processes related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.81 IL4 ICOSLG CD8A CD40LG
2 B cell differentiation GO:0030183 9.71 IL4 IL10 CD40LG
3 positive regulation of T cell proliferation GO:0042102 9.65 IL4 CD40LG CD4
4 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.55 IL4 IL10
5 positive regulation of MHC class II biosynthetic process GO:0045348 9.52 IL4 IL10
6 immune response GO:0006955 9.5 TNF IL4 IL10 CD8A CD40LG CD4
7 endothelial cell apoptotic process GO:0072577 9.49 TNF IL10
8 positive regulation of mononuclear cell migration GO:0071677 9.46 TNF IL4
9 type 2 immune response GO:0042092 9.43 IL4 IL10
10 negative regulation of cytokine production involved in immune response GO:0002719 9.4 TNF IL10
11 regulation of immunoglobulin secretion GO:0051023 9.37 TNF CD40LG
12 negative regulation of cytokine secretion involved in immune response GO:0002740 9.32 TNF IL10
13 regulation of isotype switching GO:0045191 9.26 IL4 IL10
14 receptor biosynthetic process GO:0032800 9.16 TNF IL10
15 T cell activation GO:0042110 8.92 IL4 ICOSLG CD8A CD4

Molecular functions related to Parasitic Protozoa Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL4 IL10 CD40LG

Sources for Parasitic Protozoa Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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