MCID: PRT029
MIFTS: 49

Parathyroid Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Parathyroid Adenoma

MalaCards integrated aliases for Parathyroid Adenoma:

Name: Parathyroid Adenoma 12 29 55 6 15 73
Adenoma of the Parathyroid Gland 12
Adenoma of Parathyroid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7608
MeSH 44 D010282
NCIt 50 C3916
SNOMED-CT 68 128474007
UMLS 73 C0262587

Summaries for Parathyroid Adenoma

MalaCards based summary : Parathyroid Adenoma, also known as adenoma of the parathyroid gland, is related to hyperparathyroidism 1 and chief cell adenoma. An important gene associated with Parathyroid Adenoma is CDC73 (Cell Division Cycle 73), and among its related pathways/superpathways are G alpha (s) signalling events and Parathyroid hormone synthesis, secretion and action. The drugs Denosumab and Vitamin D have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related phenotypes are endocrine/exocrine gland and cardiovascular system

Wikipedia : 76 A parathyroid adenoma is a benign tumor of the parathyroid gland. It generally causes... more...

Related Diseases for Parathyroid Adenoma

Diseases related to Parathyroid Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 hyperparathyroidism 1 33.8 CDC73 MEN1
2 chief cell adenoma 32.5 GCM2 PTH
3 hyperparathyroidism 2 with jaw tumors 32.4 CASR CCND1 CDC73 MEN1 RET
4 adenoma 31.5 CASR CCND1 CDC73 MEN1 RET
5 osteitis fibrosa 31.1 BGLAP CALCA CASR PTH
6 multiple endocrine neoplasia, type iia 30.9 CALCA CDC73 MEN1 PTH RET
7 invasive malignant thymoma 30.6 PTH PTHLH
8 familial hypocalciuric hypercalcemia 30.3 CASR CDC73 PTH
9 parathyroid carcinoma 30.2 CALCA CASR CCND1 CDC73 MEN1 PTH
10 rickets 29.4 BGLAP PTH VDR
11 multiple endocrine neoplasia 29.1 CALCA CHGA MEN1 RET
12 pheochromocytoma 28.8 CALCA CHGA MEN1 RET
13 thyroid carcinoma, familial medullary 28.8 CALCA CHGA MEN1 RET
14 thyroid cancer 28.7 CALCA CCND1 CHGA RET
15 thyroid cancer, nonmedullary, 2 28.5 CALCA CHGA MEN1 RET
16 multiple endocrine neoplasia, type i 28.3 CASR CDC73 CDKN2C CHGA MEN1 PTH
17 secondary hyperparathyroidism of renal origin 27.8 BGLAP CALCA CASR PTH VDR
18 osteomalacia 27.6 BGLAP CALCA CASR PTHLH VDR
19 bone disease 27.4 BGLAP CALCA CASR PTH PTHLH VDR
20 hyperparathyroidism 25.8 BGLAP CALCA CASR CDC73 CHGA GCM2
21 primary hyperparathyroidism 25.2 BGLAP CALCA CASR CCND1 CDC73 CHGA
22 mixed cell type adenoma of parathyroid 12.1
23 birt-hogg-dube syndrome 11.3
24 parathyroid transitional clear cell adenoma 10.8 MEN1 PTH
25 mediastinitis 10.6
26 oncogenic osteomalacia 10.6 PTH PTHLH
27 hypocalciuric hypercalcemia, familial, type ii 10.6 CASR PTH
28 axial osteomalacia 10.6 BGLAP PTH
29 thyroiditis 10.5
30 liver sarcoma 10.5 CHGA PTHLH
31 endocrine organ benign neoplasm 10.5 CDC73 MEN1 PTH
32 organ system benign neoplasm 10.5 CDC73 MEN1 PTH
33 carcinoid tumors, intestinal 10.5 CHGA MEN1
34 clear cell adenoma 10.5 MEN1 PTH PTHLH
35 hypocalciuric hypercalcemia, familial, type iii 10.5 CASR PTH PTHLH
36 hyperparathyroidism 3 10.5 CDC73 GCM2 MEN1
37 jaw cancer 10.4 PTH PTHLH
38 hypervitaminosis d 10.4 PTH VDR
39 multiple endocrine neoplasia, type iv 10.4 CDKN2C MEN1 RET
40 sclerosing hepatic carcinoma 10.4 CHGA PTH PTHLH
41 hypercalciuria, absorptive, 2 10.4 CASR VDR
42 hypoparathyroidism, familial isolated 10.4 CASR GCM2 PTH
43 impaired renal function disease 10.3 BGLAP PTH
44 tanycytic ependymoma 10.3 CHGA MEN1
45 cervicitis 10.3
46 extraskeletal chondroma 10.3 BGLAP PTH PTHLH
47 duodenal gastrinoma 10.3 CHGA MEN1
48 thyroid cancer, nonmedullary, 1 10.2
49 gastrointestinal stromal tumor 10.2 CCND1 CHGA MEN1
50 pseudohypoparathyroidism, type ib 10.2 BGLAP PTH PTHLH

Graphical network of the top 20 diseases related to Parathyroid Adenoma:



Diseases related to Parathyroid Adenoma

Symptoms & Phenotypes for Parathyroid Adenoma

MGI Mouse Phenotypes related to Parathyroid Adenoma:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.23 PTHLH GCM2 MEN1 RET PTH VDR
2 cardiovascular system MP:0005385 10.22 PTHLH MEN1 RET PTH CHGA VDR
3 cellular MP:0005384 10.21 GCM2 PTHLH MEN1 RET PTH VDR
4 growth/size/body region MP:0005378 10.17 CHGA PTHLH MEN1 RET PTH VDR
5 homeostasis/metabolism MP:0005376 10.15 GCM2 PTHLH MEN1 RET PTH CHGA
6 digestive/alimentary MP:0005381 10.08 PTHLH MEN1 RET VDR CCND1 ABCB1
7 hematopoietic system MP:0005397 10.06 PTHLH PTH VDR RET CASR CDKN2C
8 craniofacial MP:0005382 10.04 GCM2 PTHLH MEN1 PTH VDR CCND1
9 mortality/aging MP:0010768 10.03 GCM2 PTHLH MEN1 RET PTH CHGA
10 immune system MP:0005387 10.02 PTHLH MEN1 RET PTH VDR CDKN2C
11 nervous system MP:0003631 9.81 GCM2 PTHLH MEN1 VDR RET CDKN2C
12 renal/urinary system MP:0005367 9.56 PTHLH GCM2 RET CHGA VDR CDC73
13 reproductive system MP:0005389 9.28 CHGA PTHLH MEN1 RET VDR CDKN2C

Drugs & Therapeutics for Parathyroid Adenoma

Drugs for Parathyroid Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 3 615258-40-7
2
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
3 Vitamins Phase 3
4 Bone Density Conservation Agents Phase 3
5 Calcium, Dietary Phase 3,Not Applicable
6 Hormones Phase 3,Not Applicable
7 Hormone Antagonists Phase 3,Not Applicable
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
9 Cinacalcet Hydrochloride Phase 3
10 Calcimimetic Agents Phase 3
11
Choline Approved, Nutraceutical Phase 2 62-49-7 305
12 Gastrointestinal Agents Phase 2
13 Nootropic Agents Phase 2
14 Hypolipidemic Agents Phase 2
15 Lipid Regulating Agents Phase 2
16 Antimetabolites Phase 2
17 Micronutrients
18 Trace Elements
19 Anesthetics
20 Fluorides Not Applicable

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Minimizing Narcotic Analgesics After Endocrine Surgery Recruiting NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
2 Treatment of Primary Hyperparathyroidism With Denosumab and Cinacalcet. Enrolling by invitation NCT03027557 Phase 3 Cinacalcet 30 mg Tablet;Denosumab Inj 60 mg/ml
3 Interest of the F18-choline as a Second Line of the Tracer for Detection of Parathyroid Adenomas Completed NCT02432599 Phase 2
4 Input of C11-Choline PET/CT in Localization of Parathyroid Adenoma Unknown status NCT01221896
5 Evaluation of a New CZT System Unknown status NCT01084356
6 Differentially Expressed Proteins in Sporadic Parathyroid Tumors Unknown status NCT01647503
7 Regulation of Vitamin D Receptor (VDR),Calcium Sensing Receptor (CaSR), Cyclin D1,Ki67 and Proliferating Cell Nuclear Antigen (PCNA) in Primary Hyperparathyroidism Unknown status NCT01228786
8 Observation of Histological Changes in Parathyroid Adenomas Following High Intensity Focused Ultrasound (HIFU) Treatment Procedure Completed NCT01060982 Not Applicable
9 Using X-Ray Dye to Locate Hidden Parathyroid Tumors Completed NCT00001394
10 Minimally Invasive Radioguided Parathyroidectomy Completed NCT01530919
11 Open Versus Video-Assisted Minimal-Invasive Parathyroid Surgery Completed NCT00877981 Not Applicable
12 Anti-3-[18F]FACBC Imaging of Parathyroid Adenomas Recruiting NCT01574287 Not Applicable FACBC
13 Omission of Intact Parathyroid Hormone Testing During Surgery in Treating Patients With Primary Hyperparathyroidism Recruiting NCT03011736 Not Applicable
14 Molecular and IHC Profiling of PTH Tumors to Evaluate Targeted Agents Recruiting NCT03039439
15 Localization of Parathyroid Adenoma by Fluorocholine PET/MRI (Positron Emission Tomography -MRI) Not yet recruiting NCT02843542 Not Applicable
16 FCH PET/MRI Parathyroid Localization Not yet recruiting NCT03324893 Not Applicable
17 Preoperational Fine Needle Aspiration of Pathological Parathyroid Gland Not yet recruiting NCT03516747 Not Applicable
18 High Intensity Focused Ultrasound (HIFU) for Parathyroid Adenoma Terminated NCT01291498 Not Applicable
19 Evaluation of MRI and SPECT Fusion Software to Localize Parathyroid Adenomas Terminated NCT00639405
20 Multicenter Registry Comparing Preoperative Imaging for Primary Hyperparathyroidism Withdrawn NCT02381925

Search NIH Clinical Center for Parathyroid Adenoma

Genetic Tests for Parathyroid Adenoma

Genetic tests related to Parathyroid Adenoma:

# Genetic test Affiliating Genes
1 Parathyroid Adenoma 29

Anatomical Context for Parathyroid Adenoma

MalaCards organs/tissues related to Parathyroid Adenoma:

41
Thyroid, Bone, Testes, Lymph Node, Lung, Kidney, Thymus

Publications for Parathyroid Adenoma

Articles related to Parathyroid Adenoma:

(show top 50) (show all 755)
# Title Authors Year
1
A Migratory Mishap: Giant Mediastinal Parathyroid Adenoma. ( 29360437 )
2018
2
Dynamic CT for Parathyroid Adenoma Detection: How Does Radiation Dose Compare With Nuclear Medicine? ( 29629803 )
2018
3
Localization of Parathyroid Adenoma Using Contrast-Enhanced Sonography. ( 29781147 )
2018
4
A Novel Technology for Localization of Parathyroid Adenoma: Ultrasound-Guided Fine Needle Aspiration Combined With Rapid Parathyroid Hormone Detection and Nano-Carbon Technology. ( 29890904 )
2018
5
Severe Acute Pancreatitis as an Index Clinical Manifestation of Parathyroid Adenoma. ( 29888149 )
2018
6
Ectopic Undescended Parathyroid Adenoma-SPECT/CT Avoids False-Negative Interpretation on 99mTc-MIBI Dual-Phase Scintigraphy. ( 29293139 )
2018
7
Role of fine needle aspiration cytology in diagnosis of brown tumor secondary to parathyroid adenoma. ( 29403220 )
2018
8
Clinical value of 11C-methionine positron emission tomography in persistent primary hyperparathyroidism-A case report with a mediastinal parathyroid adenoma. ( 29573598 )
2018
9
Facial Dysmorphism Due to Multiple Brown Tumors Secondary to Large Parathyroid Adenoma, Diagnosed on <sup>99m</sup>Tc-Sestamibi Parathyroid Scintigraphy. ( 29962730 )
2018
10
Cervical haematoma secondary to spontaneous bleeding of parathyroid adenoma. ( 29751932 )
2018
11
Highly specific preoperative selection of solitary parathyroid adenoma cases in primary hyperparathyroidism by quantitative image analysis of the early-phase Technetium-99m sestamibi scan. ( 29877611 )
2018
12
Localisation of ectopic mediastinal parathyroid adenoma by 18F-fluorocholine PET/CT. ( 29592976 )
2018
13
Parathyroid, Adenoma ( 29939647 )
2018
14
Incidental Detection of Parathyroid Adenoma on Somatostatin Receptor PET/CT and Incremental RoleA of <sup>18</sup>F-Fluorocholine PET/CT in MEN1 Syndrome. ( 29942404 )
2018
15
[<sup>18</sup>F]Fluorocholine Uptake of Parathyroid Adenoma Is Correlated with Parathyroid Hormone Level. ( 29508264 )
2018
16
Feasibility of bipolar radiofrequency ablation in patients with parathyroid adenoma: a first evaluation. ( 29607692 )
2018
17
Dual Pathologies of Parathyroid Adenoma and Papillary Thyroid Cancer on Fluorocholine and Fluorodeoxyglucose PET/CT. ( 29662564 )
2018
18
An occult ectopic parathyroid adenoma in a pediatric patient: a case report and management algorithm. ( 28809753 )
2017
19
Molecular profiles of oxyphilic and chief cell parathyroid adenoma. ( 28986304 )
2017
20
Early and Delayed 18F-FCH PET/CT Imaging in Parathyroid Adenomas. ( 27941372 )
2017
21
Management of mediastinal parathyroid adenoma via minimally invasive thoracoscopic surgery: Case report. ( 28988020 )
2017
22
EZH2 copy number and mutational analyses in sporadic parathyroid adenomas. ( 27738890 )
2017
23
Decrease in size and activity of parathyroid adenoma after ultrasound guided biopsy. ( 28914043 )
2017
24
Parathyroid adenoma with concurrent toxic thyroid adenoma: a rare combination. ( 28876558 )
2017
25
Ureteropelvic Junction Obstruction and Parathyroid Adenoma: Coincidence or Link? ( 29181209 )
2017
26
Percutaneous Transsternal Cryoablation of Ectopic Parathyroid Adenoma in the Anterior Mediastinum. ( 29264453 )
2017
27
Comparative Effectiveness of Ultrasonography, 99mTc-Sestamibi, and 18F-Fluorocholine PET/CT in Detecting Parathyroid Adenomas in Patients With Primary Hyperparathyroidism. ( 28902729 )
2017
28
Percentage arterial enhancement: An objective index for accurate identification of parathyroid adenoma/hyperplasia inA primary hyperparathyroidism. ( 28656592 )
2017
29
A Herald of Plasma Cell Myeloma: A Report of Malignant Plasma Cells Identified in Parathyroid Adenoma and a Review of Non-parathyroid Malignancies in Parathyroid Glands. ( 29030756 )
2017
30
Surgery for Ectopic Parathyroid Adenoma in Lower Part of Superior Mediastinum through a Transcervical Incision. ( 28524839 )
2017
31
Primary hyperparathyroidism caused by mediastinal ectopic parathyroid adenoma. ( 28775222 )
2017
32
Giant parathyroid adenoma: differential aspects compared to parathyroid carcinoma. ( 28491324 )
2017
33
Parathyroid carcinoma in a patient with three prior parathyroid adenomas. ( 28636744 )
2017
34
Synchronous parathyroid adenoma and papillary thyroid carcinoma: 99mTc-MIBI Scan Findings. ( 29303141 )
2017
35
Excision of an Elusive Tiny Ectopic Parathyroid Adenoma. ( 29430234 )
2017
36
Concomitant occurrence of primary hyperparathyroidism (PHPT) due to mediastinal parathyroid adenoma and sublingual thyroid gland: the role of parathyroid technetium-99m-MIBI scintigraphy. ( 29152292 )
2017
37
Sensitive Detection of a Small Parathyroid Adenoma Using Fluorocholine PET/CT: A Case Report. ( 28559945 )
2017
38
Ectopic parathyroid adenoma in the pyriform sinus. ( 28741786 )
2017
39
Gestational Primary Hyperparathyroidism Due to Ectopic Parathyroid Adenoma: Case Report and Literature Review. ( 29264569 )
2017
40
Intrathymic Parathyroid Adenoma. ( 28502343 )
2017
41
Atypical Parathyroid Adenoma with Multiple Brown Tumors as Initial Presentation: A Rare Entity. ( 28533644 )
2017
42
Ambulatory surgery under local anesthesia for parathyroid adenoma: Feasibility and outcome. ( 29275894 )
2017
43
A Case of Hyperparathyroidism due to a Large Intrathyroid Parathyroid Adenoma with Recurrent Episodes of Acute Pancreatitis. ( 28815093 )
2017
44
Unilateral Exploration for Parathyroid Adenoma. ( 28546708 )
2017
45
Descended right superior parathyroid adenoma mimicking as inferior adenoma in primary hyperparathyroidism. ( 28775111 )
2017
46
Giant mediastinal parathyroid adenoma presenting as bilateral brown tumour of mandible: a rare presentation of primary hyperparathyroidism. ( 29066636 )
2017
47
Typifying the Atypical Parathyroid Adenoma. ( 28680226 )
2017
48
Non-traumatic rupture of the superior thyroid artery with concomitant parathyroid adenoma and multinodular goiter. ( 28811931 )
2017
49
Loss of p27 expression is associated with MEN1 gene mutations in sporadic parathyroid adenomas. ( 27038812 )
2017
50
Intravagal Parathyroid Adenoma With Direct Surgery. ( 28756868 )
2017

Variations for Parathyroid Adenoma

ClinVar genetic disease variations for Parathyroid Adenoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CDC73 CDC73, 4-BP DEL, 685AGAG deletion Pathogenic
2 CASR NM_000388.3(CASR): c.2449G> A (p.Val817Ile) single nucleotide variant Likely pathogenic rs1057518933 GRCh37 Chromosome 3, 122003250: 122003250
3 CASR NM_000388.3(CASR): c.2449G> A (p.Val817Ile) single nucleotide variant Likely pathogenic rs1057518933 GRCh38 Chromosome 3, 122284403: 122284403
4 MEN1 NM_000244.3(MEN1): c.669+1delG deletion Pathogenic rs1057518903 GRCh37 Chromosome 11, 64575362: 64575362
5 MEN1 NM_000244.3(MEN1): c.669+1delG deletion Pathogenic rs1057518903 GRCh38 Chromosome 11, 64807890: 64807890
6 MEN1 NM_000244.3(MEN1): c.371_372delTC (p.Val124Aspfs) deletion Pathogenic GRCh38 Chromosome 11, 64809738: 64809739
7 MEN1 NM_000244.3(MEN1): c.371_372delTC (p.Val124Aspfs) deletion Pathogenic GRCh37 Chromosome 11, 64577210: 64577211

Copy number variations for Parathyroid Adenoma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 25580 1 191357783 191487679 Loss HRPT2 Parathyroid adenoma
2 33979 1 51206195 51212897 Loss CDKN2C Parathyroid adenoma
3 33993 1 51300000 56200000 Loss RNF11 Parathyroid adenoma
4 48482 11 1 48800000 Losse MEN1 Parathyroid adenoma
5 192952 5 121500000 127300000 Gaine LMNB1 Parathyroid adenoma
6 192953 5 121500000 127300000 Gaine PIK3R1 Parathyroid adenoma

Expression for Parathyroid Adenoma

Search GEO for disease gene expression data for Parathyroid Adenoma.

Pathways for Parathyroid Adenoma

GO Terms for Parathyroid Adenoma

Biological processes related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.97 CCND1 CDC73 MEN1 PTH VDR
2 negative regulation of cell proliferation GO:0008285 9.77 CDC73 CDKN2C MEN1 PTHLH VDR
3 response to organic cyclic compound GO:0014070 9.72 BGLAP CASR CCND1
4 response to ethanol GO:0045471 9.69 BGLAP CCND1 PTH
5 skeletal system development GO:0001501 9.62 BGLAP PTH PTHLH VDR
6 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.61 CALCA PTH PTHLH
7 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.6 CDKN2C MEN1
8 decidualization GO:0046697 9.59 MEN1 VDR
9 vasodilation GO:0042311 9.58 CALCA CASR
10 response to pain GO:0048265 9.57 CALCA RET
11 response to vitamin D GO:0033280 9.56 BGLAP PTH
12 response to drug GO:0042493 9.55 ABCB1 BGLAP CCND1 PTH RET
13 negative regulation of chondrocyte differentiation GO:0032331 9.54 PTH PTHLH
14 positive regulation of ossification GO:0045778 9.52 CALCA PTH
15 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.49 PTH PTHLH
16 positive regulation of cAMP metabolic process GO:0030816 9.48 CALCA CHGA
17 cellular response to vitamin D GO:0071305 9.46 BGLAP CASR
18 response to fibroblast growth factor GO:0071774 9.4 CASR PTH
19 cAMP metabolic process GO:0046058 9.26 PTH PTHLH
20 osteoblast development GO:0002076 9.13 BGLAP MEN1 PTHLH
21 cellular calcium ion homeostasis GO:0006874 9.02 CALCA CASR GCM2 PTH VDR

Molecular functions related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 CALCA PTH PTHLH
2 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Parathyroid Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....