MCID: PRT029
MIFTS: 51

Parathyroid Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Parathyroid Adenoma

MalaCards integrated aliases for Parathyroid Adenoma:

Name: Parathyroid Adenoma 12 54 6 15 17 70
Adenoma of the Parathyroid Gland 12
Adenoma of Parathyroid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7608
MeSH 44 D010282
NCIt 50 C3916
SNOMED-CT 67 128474007
UMLS 70 C0262587

Summaries for Parathyroid Adenoma

Disease Ontology : 12 A parathyroid gland benign neoplam that is located in the parathyroid.

MalaCards based summary : Parathyroid Adenoma, also known as adenoma of the parathyroid gland, is related to hyperparathyroidism 2 with jaw tumors and hyperparathyroidism 1. An important gene associated with Parathyroid Adenoma is MEN1 (Menin 1), and among its related pathways/superpathways are Signaling by GPCR and Endometrial cancer. The drugs Choline and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include parathyroid, thyroid and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 A parathyroid adenoma is a benign tumor of the parathyroid gland. It generally causes... more...

Related Diseases for Parathyroid Adenoma

Diseases related to Parathyroid Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 414)
# Related Disease Score Top Affiliating Genes
1 hyperparathyroidism 2 with jaw tumors 32.6 RET MEN1 CDC73 CCND1 CASR
2 hyperparathyroidism 1 32.6 MEN1 GCM2 CDC73
3 osteitis fibrosa 31.9 PTH CDC73 CASR CALCA BGLAP
4 parathyroid carcinoma 31.6 RET PTH MEN1 CTNNB1 CDC73 CCND1
5 multiple endocrine neoplasia 31.3 RET PTH PRKAR1A MEN1 CHGA CDKN2C
6 adenoma 31.2 TSC1 RET PTH PRKAR1A MEN1 IGF1
7 hypophosphatemia 31.0 VDR PTHLH PTH BGLAP
8 nephrolithiasis 31.0 VDR PTH MEN1 CASR BGLAP
9 multinodular goiter 30.9 VEGFA PTH CALCA
10 chief cell adenoma 30.9 PTH GCM2
11 rickets 30.9 VDR PTH CASR BGLAP
12 hyperthyroidism 30.9 PTH IGF1 CALCA BGLAP
13 clear cell adenoma 30.8 PTH MEN1 CDC73
14 hyperparathyroidism 30.7 VDR RET PTHLH PTH PRKAR1A MEN1
15 primary hyperparathyroidism 30.7 VDR RET PTHLH PTH PRKAR1A MEN1
16 thyroid gland medullary carcinoma 30.7 RET PTH MEN1 CHGA CALCA
17 goiter 30.7 VEGFA RET IGF1 CALCA BGLAP
18 pituitary adenoma 30.7 PRKAR1A MEN1 IGF1 CHGA
19 constipation 30.7 RET PTH CHGA CALCA
20 secondary hyperparathyroidism 30.7 VDR PTH MEN1 CASR CALCA BGLAP
21 thyroid gland disease 30.6 RET PTH IGF1 CALCA
22 thyroid carcinoma, familial medullary 30.5 RET PRKAR1A MEN1 CHGA CALCA
23 follicular adenoma 30.5 RET PTHLH MEN1 CALCA
24 parathyroid transitional clear cell adenoma 30.5 PTH MEN1
25 hyperprolactinemia 30.5 PTHLH PTH IGF1
26 paraganglioma 30.5 RET MEN1 CHGA CALCA
27 myeloma, multiple 30.4 VEGFA IGF1 CTNNB1 CDKN2C CCND1
28 nodular goiter 30.4 VEGFA RET CALCA
29 hypocalciuric hypercalcemia, familial, type i 30.4 PTH CDC73 CASR
30 oncogenic osteomalacia 30.3 PTHLH PTH
31 multiple endocrine neoplasia, type i 30.3 RET PTH PRKAR1A MEN1 CHGA CDKN2C
32 tuberous sclerosis 30.3 VEGFA TSC1 IGF1 CHGA
33 fibrous dysplasia 30.2 IGF1 CDC73 CALCA BGLAP
34 invasive malignant thymoma 30.2 PTHLH PTH
35 carcinoid syndrome 30.2 VEGFA MEN1 IGF1 CHGA CALCA
36 pancreatic cholera 30.2 MEN1 CHGA CALCA
37 calciphylaxis 30.2 VDR PTH CASR
38 bone disease 30.2 VEGFA VDR PTHLH PTH IGF1 CASR
39 fibroma 30.2 TSC1 CTNNB1 CDC73
40 acromegaly 30.2 PRKAR1A MEN1 IGF1 BGLAP
41 vipoma 30.2 MEN1 CHGA CALCA
42 meningioma, familial 30.2 VEGFA RET PRKAR1A MEN1 CDKN2C
43 thyroid tumor 30.2 RET PRKAR1A
44 osteomalacia 30.1 VDR PTHLH PTH CASR CALCA BGLAP
45 end stage renal disease 30.1 VEGFA VDR PTH CASR
46 bone resorption disease 30.1 VDR PTHLH PTH IGF1 CTNNB1 CALCA
47 hyperparathyroidism, neonatal severe 30.1 PRKAR1A CASR
48 uremia 30.1 VDR PTH MEN1 CASR
49 suppression of tumorigenicity 12 30.0 VEGFA CTNNB1 CHGA
50 craniopharyngioma 30.0 VEGFA IGF1 CTNNB1

Graphical network of the top 20 diseases related to Parathyroid Adenoma:



Diseases related to Parathyroid Adenoma

Symptoms & Phenotypes for Parathyroid Adenoma

GenomeRNAi Phenotypes related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

26 (show all 35)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.8 BGLAP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.8 IGF1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.8 BGLAP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.8 PRKAR1A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.8 BGLAP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.8 RET
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.8 IGF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.8 IGF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.8 BGLAP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.8 IGF1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.8 IGF1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.8 BGLAP IGF1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.8 BGLAP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.8 BGLAP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.8 IGF1 RET
16 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.8 BGLAP
17 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.8 BGLAP
18 Increased shRNA abundance (Z-score > 2) GR00366-A-193 9.8 IGF1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.8 PRKAR1A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.8 IGF1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.8 RET
22 Increased shRNA abundance (Z-score > 2) GR00366-A-28 9.8 RET
23 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.8 IGF1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.8 RET
25 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.8 RET
26 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.8 RET
27 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.8 RET
28 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.8 IGF1
29 Decreased viability GR00221-A-1 9.77 CDKN2C RET
30 Decreased viability GR00221-A-2 9.77 RET TSC1
31 Decreased viability GR00221-A-3 9.77 TSC1
32 Decreased viability GR00221-A-4 9.77 RET
33 Decreased viability GR00249-S 9.77 CDKN2C CDKN2D
34 Decreased viability GR00301-A 9.77 CDKN2C CDKN2D RET TSC1
35 Decreased viability GR00402-S-2 9.77 RET

MGI Mouse Phenotypes related to Parathyroid Adenoma:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.52 BGLAP CASR CCND1 CDC73 CDKN2C CDKN2D
2 endocrine/exocrine gland MP:0005379 10.51 BGLAP CASR CCND1 CDC73 CDKN2C CDKN2D
3 homeostasis/metabolism MP:0005376 10.48 BGLAP CASR CCND1 CDC73 CDKN2C CDKN2D
4 growth/size/body region MP:0005378 10.45 CASR CCND1 CDC73 CDKN2C CDKN2D CHGA
5 cardiovascular system MP:0005385 10.44 CCND1 CDC73 CDKN2C CHGA CTNNB1 IGF1
6 mortality/aging MP:0010768 10.39 CASR CCND1 CDC73 CDKN2C CDKN2D CHGA
7 behavior/neurological MP:0005386 10.38 CASR CCND1 CDC73 CDKN2C CDKN2D CTNNB1
8 immune system MP:0005387 10.36 BGLAP CASR CCND1 CDC73 CDKN2C CTNNB1
9 hematopoietic system MP:0005397 10.35 BGLAP CASR CCND1 CDC73 CDKN2C CTNNB1
10 craniofacial MP:0005382 10.32 CASR CCND1 CDC73 CTNNB1 GCM2 MEN1
11 digestive/alimentary MP:0005381 10.27 CASR CCND1 CDC73 CTNNB1 MEN1 PRKAR1A
12 integument MP:0010771 10.24 CASR CCND1 CDC73 CDKN2C CTNNB1 IGF1
13 nervous system MP:0003631 10.24 CASR CCND1 CDC73 CDKN2C CDKN2D CHGA
14 embryo MP:0005380 10.22 CASR CDC73 CTNNB1 GCM2 MEN1 PRKAR1A
15 muscle MP:0005369 10.21 CASR CDC73 CDKN2D CHGA CTNNB1 IGF1
16 neoplasm MP:0002006 10.18 CCND1 CDC73 CDKN2C CDKN2D CTNNB1 IGF1
17 reproductive system MP:0005389 10.13 BGLAP CCND1 CDC73 CDKN2C CDKN2D CHGA
18 renal/urinary system MP:0005367 10.1 CASR CDC73 CDKN2C CHGA CTNNB1 GCM2
19 limbs/digits/tail MP:0005371 10.02 CTNNB1 IGF1 PTH PTHLH RET VDR
20 respiratory system MP:0005388 9.9 CCND1 CDC73 CDKN2C CDKN2D CTNNB1 IGF1
21 skeleton MP:0005390 9.77 BGLAP CASR CCND1 CDC73 CTNNB1 GCM2
22 vision/eye MP:0005391 9.28 CASR CCND1 CDKN2D CTNNB1 PRKAR1A PTH

Drugs & Therapeutics for Parathyroid Adenoma

Drugs for Parathyroid Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Choline Approved, Nutraceutical Phase 3 62-49-7 305
2 Gastrointestinal Agents Phase 3
3 Antimetabolites Phase 3
4 Nootropic Agents Phase 3
5 Lipid Regulating Agents Phase 3
6 Technetium Tc 99m Sestamibi Phase 3
7 Hypolipidemic Agents Phase 3
8
Parathyroid hormone Approved, Investigational 9002-64-6
9 Hormone Antagonists
10 Hormones
11 Calcium, Dietary
12 Sodium Pertechnetate Tc 99m
13 Dermatologic Agents
14 Fluorides
15
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Phase III Trial Comparing 2 Diagnostic Strategies for Preoperative Localization of Parathyroid Adenoma in Primary Hyperparathyroidism:TEMP / CT With Tc99m-sestaMIBI or PET / CT With F18-choline in First Intention Recruiting NCT04040946 Phase 3
2 18F-Fluorocholine for the Detection of Parathyroid Adenomas Recruiting NCT03764007 Phase 2, Phase 3 Fluorocholine PET
3 Interest of the F18-choline as a Second Line of the Tracer for Detection of Parathyroid Adenomas Completed NCT02432599 Phase 2
4 Ultrasound Guided Fine Needle Aspiration of Parathyroid Gland as a Pre Operative Localization Tool to Identify Pathological Parathyroid Unknown status NCT03516747
5 Evaluation of a New CZT System for Imaging in Routine Nuclear Medicine Examination Unknown status NCT01084356
6 Input of C11-Choline PET/CT in Localization of Parathyroid Adenoma Unknown status NCT01221896
7 Localization of Parathyroid Adenoma by Fluorocholine Positron Emission Tomography/MRI (PET/MRI): A Prospective Pilot Study Unknown status NCT02843542
8 Observation of Histological Changes in Parathyroid Adenomas Following High Intensity Focused Ultrasound (HIFU)Treatment Procedure: A Monocentre, Open, Uncontrolled Study Completed NCT01060982
9 Use of Hypocalcemic Intraarterial Infusion Into the Thyroid/Parathyroid Bed to Localize Occult Parathyroid Adenomas Completed NCT00001394
10 Amino Acid Transport Imaging of Parathyroid Adenomas With Anti-3-[18F]FACBC Completed NCT01574287 FACBC
11 The Utility of 18F-fluorocholine PET/CT in the Imaging of Parathyroid Adenomas Completed NCT04570033
12 Impact of Parathyroidectomy on Renal Function in Patients With Primary Hyperparathyroidism Recruiting NCT04798092
13 Comparison of CEUS With Conventional Ultrasound (US) to Dual-tracer 99mTcO4-/99mTc-MIBI Subtraction Scintigraphy With SPECT/CT Combined With US for Localizing Pathological Parathyroid Glands in Patients With Primary Hyperparathyroidism Recruiting NCT04305561
14 Evaluating Impact of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy Recruiting NCT04299425
15 18F-Fluorocholine PET/MRI for the Localization of Parathyroid Adenomas Active, not recruiting NCT03324893
16 Cohort Trial on Perioperative Localization Techniques of Parathyroid Adenomas Not yet recruiting NCT04013100
17 High Intensity Focused Ultrasound (HIFU) for Parathyroid Adenoma Terminated NCT01291498
18 Localization of Parathyroid Adenomas Using MRI and SPECT Fusion Software in Patients With Persistent or Recurrent Hyperparathyroidism Terminated NCT00639405
19 Multicenter Registry Comparing Preoperative Imaging for Primary Hyperparathyroidism Withdrawn NCT02381925

Search NIH Clinical Center for Parathyroid Adenoma

Genetic Tests for Parathyroid Adenoma

Anatomical Context for Parathyroid Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Parathyroid Adenoma:

19
Parathyroid

MalaCards organs/tissues related to Parathyroid Adenoma:

40
Thyroid, Breast, Pituitary, Lymph Node, Thymus, Kidney, Bone Marrow

Publications for Parathyroid Adenoma

Articles related to Parathyroid Adenoma:

(show top 50) (show all 3780)
# Title Authors PMID Year
1
Diagnosis of parathyroid tumors in familial isolated hyperparathyroidism with HRPT2 mutation: implications for cancer surveillance. 61 6
16720667 2006
2
Calcium-sensing receptor autoantibodies in primary hyperparathyroidism. 54 61
19520070 2009
3
Association of parathyroid adenoma and familial hypocalciuric hypercalcaemia in a teenager. 54 61
19423559 2009
4
Diagnosis and surgical treatment of multiple endocrine neoplasia. 61 54
19719936 2009
5
Clinical, genetic, and histopathologic investigation of CDC73-related familial hyperparathyroidism. 61 54
18755853 2008
6
Chromosome 11 genomic changes in parathyroid adenoma and hyperplasia: array CGH, FISH, and tissue microarrays. 54 61
18398822 2008
7
Substernal oxyphil parathyroid adenoma producing PTHrP with hypercalcemia and normal PTH level. 61 54
18291038 2008
8
Immunohistochemical assessment of parafibromin in mouse and human tissues. 61 54
17118068 2006
9
Mutational analysis of the PTH 3'-untranslated region in parathyroid disorders. 54 61
17121534 2006
10
Primary hyperparathyroidism with a low-normal, atypical serum parathyroid hormone as shown by discordant immunoassay curves. 54 61
16849415 2006
11
HRPT2 gene alterations in ossifying fibroma of the jaws. 61 54
16458039 2006
12
Primary hyperparathyroidism mimicking vaso-occlusive crises in sickle cell disease. 61 54
16882790 2006
13
Genetic aberrance of sporadic MEN 2A component tumours: analysis of RET. 54 61
15875728 2005
14
Minireview: Cyclin D1: normal and abnormal functions. 61 54
15331580 2004
15
Novel somatic MEN1 gene alterations in sporadic primary hyperparathyroidism and correlation with clinical characteristics. 54 61
15754732 2004
16
Calcium-sensing receptor autoantibodies are relevant markers of acquired hypoparathyroidism. 61 54
15356052 2004
17
Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene. 61 54
15168774 2004
18
Recurrent hypercalcemia due to ectopic production of parathyroid hormone-related protein and intact parathyroid hormone in a single patient with multiple malignancies. 54 61
15256329 2004
19
Preoperative diagnosis of suspicious parathyroid adenomas by RT-PCR using mRNA extracted from leftover cells in a needle used for ultrasonically guided fine needle aspiration cytology. 54 61
12585024 2003
20
Immunohistochemical detection of cell cycle regulators, Fhit protein and apoptotic cells in parathyroid lesions. 61 54
12534361 2003
21
Exclusive underexpression of vitamin D receptor exon 1f transcripts in tumors of primary hyperparathyroidism. 61 54
12444900 2002
22
Using technetium 99m tetrofosmin parathyroid imaging to detect parathyroid adenoma and its relation to P-glycoprotein expression. 61 54
12324759 2002
23
Technetium-99m methoxyisobutylisonitrile imaging for parathyroid adenoma: relationship to P-glycoprotein or multidrug resistance-related protein expression. 54 61
12173014 2002
24
Detecting parathyroid adenoma using technetium-99m tetrofosmin: comparison with P-glycoprotein and multidrug resistance related protein expression--a preliminary report. 61 54
11929704 2002
25
Immunohistochemistry of cyclin D1 and beta-catenin, and mutational analysis of exon 3 of beta-catenin gene in parathyroid adenomas. 61 54
11836555 2002
26
Correlation between P-glycoprotein (P-gp) expression in parathyroid and Tc-99m MIBI parathyroid image findings. 61 54
11711312 2001
27
Genetic analysis of a papillary thyroid carcinoma in a patient with MEN1. 61 54
11352308 2001
28
Deletion of 11q23 and cyclin D1 overexpression are frequent aberrations in parathyroid adenomas. 61 54
11290553 2001
29
Molecular pathology of parathyroid tumors. 61 54
11167122 2001
30
The role of hyperplasia in multiple parathyroid adenomas. 61 54
11303630 2001
31
Pancreastatin plasma levels in patients with primary hyperparathyroidism. 54 61
11193727 2000
32
A newly recognized germline mutation of MEN1 gene identified in a patient with parathyroid adenoma and carcinoma. 61 54
10963041 2000
33
Reduced parathyroid vitamin D receptor messenger ribonucleic acid levels in primary and secondary hyperparathyroidism. 61 54
10843188 2000
34
Cyclin D1 in parathyroid disease. 54 61
10704427 2000
35
Effect of vitamin D nutrition on parathyroid adenoma weight: pathogenetic and clinical implications. 54 61
10720039 2000
36
Identification of a novel activated form of the keratinocyte growth factor receptor by expression cloning from parathyroid adenoma tissue. 54 61
10523826 1999
37
Relationship between Ca-dependent change of serum PTH and extracellular Ca2+-sensing receptor expression in parathyroid adenoma. 54 61
10024390 1999
38
Mechanism of parathyroid tumourigenesis in uraemia. 54 61
10048455 1999
39
Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias. 54 61
10548885 1999
40
Primary hyperparathyroidism-associated polyostotic fibrous dysplasia: absence of McCune-Albright syndrome mutations. 54 61
9413810 1997
41
Parathyroid function and histology in patients with parathyroid adenoma: correlation of clinical and morphologic findings. 54 61
9204747 1997
42
Vitamin D receptor polymorphisms correlate to parathyroid cell function in primary hyperparathyroidism. 61 54
9177380 1997
43
Co-secretion of parathyroid hormone and parathyroid-hormone-related protein via a regulated pathway in human parathyroid adenoma cells. 54 61
9060824 1997
44
Somatic mutations of the ret protooncogene in sporadic medullary thyroid carcinoma are not restricted to exon 16 and are associated with tumor recurrence. 61 54
8636377 1996
45
Absence of cyclin D1/PRAD1 point mutations in human breast cancers and parathyroid adenomas and identification of a new cyclin D1 gene polymorphism. 61 54
7621424 1995
46
Inhibition of parathyroid hormone-related protein release by extracellular calcium in dispersed cells from human parathyroid hyperplasia secondary to chronic renal failure and adenoma. 54 61
7778690 1995
47
Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. 54 61
7759551 1995
48
P-glycoprotein is expressed in parathyroid epithelium and is regulated by calcium. 61 54
7736328 1995
49
Clonal analysis of parathyroid adenomas by means of the polymerase chain reaction. 54 61
7910112 1994
50
Light microscopical immunohistochemical study on parathyroid adenoma in primary hyperparathyroidism. 54 61
7515533 1994

Variations for Parathyroid Adenoma

ClinVar genetic disease variations for Parathyroid Adenoma:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CDC73 NM_024529.4(CDC73):c.679_680AG[3] (p.Arg229fs) Microsatellite Pathogenic 3278 rs760591174 GRCh37: 1:193111146-193111149
GRCh38: 1:193142016-193142019
2 MEN1 NM_000244.3(MEN1):c.371_372del (p.Val124fs) Deletion Pathogenic 523339 rs1555166368 GRCh37: 11:64577210-64577211
GRCh38: 11:64809738-64809739
3 MEN1 NM_000244.3(MEN1):c.669+1del Deletion Pathogenic 374107 rs1057518903 GRCh37: 11:64575362-64575362
GRCh38: 11:64807890-64807890
4 CASR NM_000388.4(CASR):c.2449G>A (p.Val817Ile) SNV Likely pathogenic 374153 rs1057518933 GRCh37: 3:122003250-122003250
GRCh38: 3:122284403-122284403

Copy number variations for Parathyroid Adenoma from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 25580 1 191357783 191487679 Loss CDC73 Parathyroid adenoma
2 33979 1 51206195 51212897 Loss CDKN2C Parathyroid adenoma
3 33993 1 51300000 56200000 Loss RNF11 Parathyroid adenoma
4 48482 11 1 48800000 Losse MEN1 Parathyroid adenoma
5 192952 5 121500000 127300000 Gaine LMNB1 Parathyroid adenoma
6 192953 5 121500000 127300000 Gaine PIK3R1 Parathyroid adenoma

Expression for Parathyroid Adenoma

Search GEO for disease gene expression data for Parathyroid Adenoma.

Pathways for Parathyroid Adenoma

Pathways related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 VEGFA TSC1 RET PTHLH PTH PRKAR1A
2
Show member pathways
12.72 VEGFA RET IGF1 CTNNB1 CCND1
3 12.68 VEGFA RET IGF1 CTNNB1 CCND1
4
Show member pathways
12.51 TSC1 RET IGF1 CDKN2C CCND1
5
Show member pathways
12.25 PTHLH PRKAR1A CTNNB1 CDC73 CCND1
6 12.2 MEN1 CDKN2D CDKN2C CCND1
7 12.14 VEGFA IGF1 CTNNB1 CCND1
8 11.98 VEGFA PRKAR1A CTNNB1 CCND1
9 11.94 VEGFA RET PRKAR1A CTNNB1
10 11.89 VEGFA TSC1 CTNNB1 CCND1
11 11.74 PTH IGF1 BGLAP
12 11.67 TSC1 IGF1 CTNNB1 CCND1
13 11.46 VDR PTHLH PTH GCM2 CASR BGLAP
14 11.4 TSC1 CTNNB1 CCND1
15 11.37 VEGFA PTHLH PTH IGF1
16 11.21 VDR PTH IGF1 CALCA BGLAP
17 10.74 PTH BGLAP
18 10.69 VDR PTHLH PTH PRKAR1A CCND1 BGLAP
19 10.68 MEN1 CTNNB1
20 10.55 VDR PTH

GO Terms for Parathyroid Adenoma

Biological processes related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.13 VEGFA VDR PTH MEN1 IGF1 GCM2
2 negative regulation of transcription by RNA polymerase II GO:0000122 10.09 VEGFA VDR MEN1 CTNNB1 CDC73 CCND1
3 positive regulation of cell proliferation GO:0008284 10 VEGFA PTHLH IGF1 CTNNB1 CCND1 CASR
4 negative regulation of gene expression GO:0010629 9.93 VEGFA VDR PTH IGF1 CTNNB1
5 response to drug GO:0042493 9.91 RET PTH CTNNB1 CCND1 BGLAP
6 positive regulation of gene expression GO:0010628 9.91 VEGFA VDR RET IGF1 CTNNB1 CASR
7 response to nutrient levels GO:0031667 9.77 TSC1 PTH BGLAP
8 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.77 CDKN2D CDKN2C CDC73
9 positive regulation of MAPK cascade GO:0043410 9.76 VEGFA RET IGF1 CTNNB1
10 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 9.74 CDKN2D CDKN2C CCND1
11 lactation GO:0007595 9.72 VEGFA VDR CCND1
12 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.65 MEN1 CDKN2D CDKN2C
13 negative regulation of oxidative stress-induced neuron death GO:1903204 9.63 TSC1 CTNNB1
14 cellular response to vitamin D GO:0071305 9.63 CASR BGLAP
15 positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968 9.62 CTNNB1 CDC73
16 positive regulation of positive chemotaxis GO:0050927 9.62 VEGFA CASR
17 negative regulation of cell cycle G1/S phase transition GO:1902807 9.61 MEN1 CDKN2D
18 response to fibroblast growth factor GO:0071774 9.58 PTH CASR
19 beta-catenin-TCF complex assembly GO:1904837 9.58 MEN1 CTNNB1 CDC73
20 endodermal cell fate commitment GO:0001711 9.56 CTNNB1 CDC73
21 cellular calcium ion homeostasis GO:0006874 9.55 VDR PTH GCM2 CASR CALCA
22 negative regulation of chondrocyte differentiation GO:0032331 9.54 PTHLH PTH CTNNB1
23 response to vitamin D GO:0033280 9.5 PTH CDKN2D BGLAP
24 cAMP metabolic process GO:0046058 9.49 PTHLH PTH
25 osteoblast development GO:0002076 9.43 PTHLH MEN1 BGLAP
26 skeletal system development GO:0001501 9.43 VDR PTHLH PTH IGF1 CTNNB1 BGLAP
27 negative regulation of cell proliferation GO:0008285 9.23 VDR TSC1 PTHLH MEN1 CTNNB1 CDKN2D

Molecular functions related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.35 CTNNB1 CDKN2D CDKN2C CCND1 CASR
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.26 CDKN2D CDKN2C
3 peptide hormone receptor binding GO:0051428 9.16 PTHLH PTH
4 hormone activity GO:0005179 8.92 PTHLH PTH IGF1 CALCA

Sources for Parathyroid Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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