Parathyroid Gland Disease

Categories: Endocrine diseases

Aliases & Classifications for Parathyroid Gland Disease

MalaCards integrated aliases for Parathyroid Gland Disease:

Name: Parathyroid Gland Disease 12 15
Parathyroid Diseases 44 73
Abnormality of the Parathyroid Gland 29
Disease of Parathyroid Glands 12


External Ids:

Disease Ontology 12 DOID:11201
ICD10 33 E21.5 E21.4
ICD9CM 35 252 252.9
MeSH 44 D010279
NCIt 50 C26844
SNOMED-CT 68 73132005
UMLS 73 C0030517

Summaries for Parathyroid Gland Disease

Disease Ontology : 12 An endocrine system disease that is located in the parathyroid gland.

MalaCards based summary : Parathyroid Gland Disease, also known as parathyroid diseases, is related to hypoparathyroidism and hyperparathyroidism. An important gene associated with Parathyroid Gland Disease is PTH (Parathyroid Hormone), and among its related pathways/superpathways are G alpha (s) signalling events and Ca, cAMP and Lipid Signaling. The drugs Betamethasone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and kidney, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 76 Parathyroid glands are small endocrine glands in the neck of humans and other tetrapods that produce... more...

Related Diseases for Parathyroid Gland Disease

Diseases related to Parathyroid Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 hypoparathyroidism 31.1 AIRE BGLAP CASR FGF23 GCM2 PTH
2 hyperparathyroidism 31.0 BGLAP CALCA CASR CDC73 FGF23 GCM2
3 adenoma 29.8 CASR CDC73 MEN1 RET
4 multiple endocrine neoplasia 29.7 CALCA MEN1 RET
5 familial isolated hyperparathyroidism 29.2 CASR CDC73 GCM2 MEN1 PTH RET
6 parathyroid adenoma 28.5 BGLAP CALCA CASR CDC73 GCM2 MEN1
7 primary hyperparathyroidism 28.3 ALB BGLAP CALCA CASR CDC73 FGF23
8 hypocalciuric hypercalcemia, familial, type i 10.3 CASR PTH
9 hypocalciuric hypercalcemia, familial, type ii 10.3 CASR PTH
10 parathyroid transitional clear cell adenoma 10.3 MEN1 PTH
11 sclerosing hepatic carcinoma 10.2 PTH PTHLH
12 fibrogenesis imperfecta ossium 10.2 CALCA PTH
13 hyperparathyroidism 1 10.2 CDC73 MEN1
14 axial osteomalacia 10.2 BGLAP PTH
15 invasive malignant thymoma 10.2 PTH PTHLH
16 pancreatic somatostatinoma 10.2 CALCA MEN1
17 familial hypocalciuric hypercalcemia 10.2 CASR CDC73 PTH
18 paraneoplastic syndromes 10.2 FGF23 PTHLH
19 thyroid gland disease 10.2 CALCA PTH RET
20 hypocalciuric hypercalcemia, familial, type iii 10.2 CASR PTH PTHLH
21 clear cell adenoma 10.2 MEN1 PTH PTHLH
22 cell type benign neoplasm 10.2 CDC73 MEN1 PTH
23 hypophosphatemic rickets, x-linked dominant 10.2 FGF23 PTH
24 chief cell adenoma 10.2 GCM2 PTH
25 hypoadrenalism 10.2 CALCA PTHLH
26 cloacogenic carcinoma 10.1 CALCA PTH PTHLH
27 oncogenic osteomalacia 10.1 FGF23 PTH PTHLH
28 extraskeletal chondroma 10.1 BGLAP PTH PTHLH
29 multiple endocrine neoplasia, type iib 10.1 CALCA MEN1 RET
30 islet cell tumor 10.1 CALCA MEN1 PTHLH
31 hypophosphatasia, adult 10.1 BGLAP CALCA PTH
32 pseudohypoparathyroidism, type ib 10.1 BGLAP PTH PTHLH
33 pancreatic cholera 10.1 CALCA MEN1
34 osteoporosis, juvenile 10.1 BGLAP CALCA PTH
35 multicentric carpotarsal osteolysis syndrome 10.1 BGLAP PTHLH
36 glucocorticoid-induced osteoporosis 10.1 BGLAP CALCA PTH
37 impaired renal function disease 10.1 BGLAP FGF23 PTH
38 hypervitaminosis d 10.1 FGF23 PTH VDR
39 nontoxic goiter 10.1 BGLAP CALCA
40 paget's disease of bone 10.1 BGLAP CALCA PTH
41 hypophosphatemia 10.1 BGLAP FGF23 PTH
42 thyroid carcinoma, familial medullary 10.1 CALCA MEN1 RET
43 hyperparathyroidism 2 with jaw tumors 10.1 CASR CDC73 MEN1 RET
44 pulmonary alveolar microlithiasis 10.1 FGF23 PTH
45 connective tissue benign neoplasm 10.1 CDC73 PTH
46 fibrous dysplasia 10.1 BGLAP CALCA FGF23
47 endocrine organ benign neoplasm 10.1 CALCA MEN1 PTH RET
48 thyroid cancer, nonmedullary, 2 10.1 CALCA MEN1 RET
49 osteitis fibrosa 10.1 BGLAP CALCA CASR PTH
50 metaphyseal chondrodysplasia, jansen type 10.0 CALCA FGF23 PTH PTHLH

Graphical network of the top 20 diseases related to Parathyroid Gland Disease:

Diseases related to Parathyroid Gland Disease

Symptoms & Phenotypes for Parathyroid Gland Disease

MGI Mouse Phenotypes related to Parathyroid Gland Disease:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 ADCY10 ALB CASR CDC73 GCM2 MEN1
2 homeostasis/metabolism MP:0005376 10.29 ADCY10 AIRE ALB CASR CDC73 FGF23
3 endocrine/exocrine gland MP:0005379 10.25 AIRE ALB CASR CDC73 FGF23 GCM2
4 mortality/aging MP:0010768 10.22 AIRE ALB CASR CDC73 FGF23 FGF3
5 cardiovascular system MP:0005385 10.21 ADCY10 CDC73 FGF23 MEN1 PPP1R3C PTH
6 growth/size/body region MP:0005378 10.19 AIRE CASR CDC73 FGF23 FGF3 MEN1
7 digestive/alimentary MP:0005381 10.18 AIRE ALB CASR CDC73 FGF23 MEN1
8 immune system MP:0005387 10.16 AIRE CASR CDC73 FGF23 FGF3 MEN1
9 craniofacial MP:0005382 10.01 CDC73 GCM2 MEN1 PTH PTHLH VDR
10 limbs/digits/tail MP:0005371 9.91 FGF23 FGF3 PTH PTHLH RET VDR
11 muscle MP:0005369 9.91 ALB CASR CDC73 MEN1 PPP1R3C RET
12 nervous system MP:0003631 9.91 AIRE CDC73 FGF3 GCM2 MEN1 PPP1R3C
13 neoplasm MP:0002006 9.8 AIRE ALB CDC73 MEN1 PTHLH RET
14 renal/urinary system MP:0005367 9.76 ALB CASR CDC73 FGF23 GCM2 PTHLH
15 reproductive system MP:0005389 9.61 ADCY10 AIRE CDC73 FGF23 FGF3 MEN1
16 skeleton MP:0005390 9.23 CASR CDC73 FGF23 FGF3 GCM2 PTH

Drugs & Therapeutics for Parathyroid Gland Disease

Drugs for Parathyroid Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 255)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 94-09-7, 1994-09-7 2337
3 tannic acid Approved Phase 4,Phase 3,Phase 2
Sevelamer Approved Phase 4,Phase 3,Phase 2,Not Applicable 52757-95-6
Calcium acetate Approved, Investigational Phase 4,Phase 3,Not Applicable 62-54-4
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1 615258-40-7
Darbepoetin alfa Approved, Investigational Phase 4 11096-26-7, 209810-58-2
Alendronate Approved Phase 4,Not Applicable 66376-36-1, 121268-17-5 2088
Zoledronic acid Approved Phase 4,Phase 1 118072-93-8 68740
Pamidronate Approved Phase 4 40391-99-9 4674
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 471-34-1
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
Codeine Approved, Illicit Phase 4 76-57-3 5284371
Acetaminophen Approved Phase 4,Phase 1,Phase 2,Not Applicable 103-90-2 1983
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Not Applicable 93-14-1 3516
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1406-16-2
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-14-6 5280793
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 67-97-0 5280795 6221
Calcitriol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 32222-06-3 5280453 134070
Alfacalcidol Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 41294-56-8 5282181
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 77-92-9 311
27 Anti-Asthmatic Agents Phase 4
28 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
29 Betamethasone acetate Phase 4
30 Betamethasone benzoate Phase 4
31 Betamethasone Valerate Phase 4 2152-44-5
32 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
33 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2,Not Applicable
34 glucocorticoids Phase 4,Phase 1,Phase 2,Not Applicable
35 Respiratory System Agents Phase 4,Not Applicable
36 Betamethasone-17,21-dipropionate Phase 4
37 Betamethasone sodium phosphate Phase 4
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
39 Calciferol Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Ergocalciferols Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Vitamin D2 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Cinacalcet Hydrochloride Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Calcimimetic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Vitamins Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
50 Retinol palmitate Phase 4

Interventional clinical trials:

(show top 50) (show all 379)
# Name Status NCT ID Phase Drugs
1 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
2 Cinacalcet in Management of Secondary Hyperparathyroidism in Haemodialysis Patients Unknown status NCT02338934 Phase 4 Combination Cinacalcet with Vitamin D analogue
3 Intravenous Paricalcitol in Chronic Hemodialysis Patients Unknown status NCT03023748 Phase 4 Intravenous Paricalcitol
4 Optimizing Treatment Programs for Chronic Kidney Disease-mineral and Bone Disorder and Malnutrition Unknown status NCT02005302 Phase 4 1,25(OH)2 Vitamin D3;Vitamin D2
5 Effect of Epidural Steroid Injection on Bone Mineral Density in Postmenopausal Women Completed NCT00941473 Phase 4 Triamcinilone (kenalog)
6 The Study of Efficacy and Safety of REGPARA Drug in Dialysis Patients Have High Blood Levels of Parathyroid Completed NCT02056730 Phase 4 calcium sensing receptor agonist
7 Denosumab in Primary Hyperparathyroidism Completed NCT01558115 Phase 4 Denosumab
8 Cincalcet and Vascular Arterial Stiffness Among Peritoneal Dialysis Patients With Secondary Hyperparathyroidism Completed NCT01143987 Phase 4 Cinacalcet
9 A Phase 4 Pharmacokinetic Study of Hectorol Injection and Zemplar Injection in CKD Subjects on Hemodialysis Completed NCT00454350 Phase 4 Hectorol (doxercalciferol injection);Zemplar (Paricalcitol injection)
10 A Phase 4, Conversion Study of Hectorol® Injection to Hectorol® Capsules in Stage 5 CKD Patients on Dialysis Completed NCT00418600 Phase 4 Hectorol® (doxercalciferol capsules);doxercalciferol capsules, Hectorol®;doxercalciferol capsules, Hectorol® capsules
11 Treatment Adhesion in Dialysis Patients Treated With Cinacalcet Completed NCT01573520 Phase 4
12 A Pilot Clinical Study Evaluating the Effect of Parathyroid Hormone (PTH) Lowering On Erythropoietin Consumption in Calcitriol-Resistant Patients Completed NCT01506947 Phase 4 Paricalcitol;Darbepoetin alfa
13 Trial to Optimize Mineral Outcomes in Dialysis Patients Completed NCT01100723 Phase 4
14 A Study of Zemplar® Injection and Hectorol® Injection on Intestinal Absorption of Calcium in Chronic Kidney Disease Completed NCT00257920 Phase 4 Zemplar® injection;Hectorol® injection
15 Study to Evaluate the Effects of Zemplar Injection and Calcijex on Intestinal Absorption of Calcium Completed NCT00073710 Phase 4 Zemplar;Calcijex
16 How Vitamin D Analogues Affect Endothelial Cells in Patients on Dialysis Completed NCT00528788 Phase 4 doxercalciferol
17 Efficacy and Safety of Paricalcitol in the Reduction of Secondary Hyperparathyroidism After Kidney Transplantation. Completed NCT01939977 Phase 4 Paricalcitol;Calcifediol
18 Systematic Treatment After Successful Surgical Treatment for Primary Hyperparathyroidism With Strontium Ranelate Completed NCT01222026 Phase 4 Strontium Ranelate + Ca/Vitamin-D;Placebo
19 Compare the Efficacy of Cinacalcet vs Traditional Vitamin D for Secondary Hyperparathyroidism (SHPT) Among Subjects Undergoing Hemodialysis Completed NCT01181531 Phase 4 Traditional Vitamin D Therapy;Cinacalcet
20 Parathyroidectomy vs Cinacalcet in the Treatment of Secondary Hyperparathyroidism Post Renal Transplantation Completed NCT01178450 Phase 4 Cinacalcet
21 Cinacalcet stUdy for Peritoneal Dialysis Patients In Double Arm on the Lowing Effect OF iPTH Level Completed NCT01101113 Phase 4 cinacalcet;control
22 Efficacy and Safety of 6 Months Treatment With Paricalcitol Injection or Oral in Patients With Secondary Hyperparathyroidism on Dialysis Completed NCT00537979 Phase 4 Paricalcitol injection;Paricalcitol capsules
23 A Phase 4 Study to Determine Dosing of Hectorol® Capsules When Converting From Zemplar® Injection Completed NCT00463021 Phase 4 Hectorol (doxercalciferol capsules);Zemplar (paricalcitol injection)
24 Initial Dosing of Paricalcitol in Secondary Hyperparathyroidism Completed NCT00307840 Phase 4 paricalcitol
25 ACHIEVE: Optimizing the Treatment of Secondary Hyperparathyroidism Completed NCT00135304 Phase 4 Sensipar®;Vitamin D
26 A Study of an Investigational Medication for Severe Primary Hyperparathyroidism or Parathyroid Cancer Completed NCT00037518 Phase 4 AMG 073
27 Efficacy of Cinacalcet in the Control of Primary Hyperparathyroidism Completed NCT02417389 Phase 4 cinacalcet;Alendronate
28 Vitamin D Repletion in Primary Hyperparathyroidism Completed NCT01306656 Phase 4 10,000 IU Vitamin D3
29 A Study of Cinacalcet to Improve Achievement of National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) Targets in Patients With End Stage Renal Disease (ESRD) Completed NCT00431496 Phase 4 Cinacalcet
30 Study of Safety and Efficacy of Doxercalciferol in Patients With Chronic Kidney Disease, Stage 3 or 4, and Secondary Hyperparathyroidism Completed NCT00123461 Phase 4 Hectorol (doxercalciferol capsules), 0.5mcg
31 Safety and Effectiveness of Zemplar Injection in Decreasing iPTH Levels in Pediatric ESRD Subjects on Hemodialysis Completed NCT00053547 Phase 4 paricalcitol injection
32 CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients Completed NCT00211939 Phase 4 calcium acetate;sevelamer;atorvastatin
33 ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis Completed NCT00379899 Phase 4 cinacalcet
34 Vitamin D Status in Males in Jerusalem Area and Its Correlation to Parathyroid Hormone (PTH) Level and Bone Mineral Density Completed NCT01025128 Phase 4 25 OH vitamin D
35 Zoledronic Acid to Prevent Bone Loss After Kidney Transplantation Completed NCT01675089 Phase 4 Zoledronic acid
36 Efficacy of Vitamin D2 to Treat Chronic Kidney Disease Mineral and Bone Disorder Completed NCT01633853 Phase 4 Vitamin D2;1,25(OH)2 Vit D3
37 Evaluation of a Cincalcet Suppression Test Completed NCT01103206 Phase 4 cinacalcet;cinacalcet dose 1;cinacalcet dose 2
38 Evaluation of the Effectiveness of Paricalcitol Versus Cinacalcet With Low-Dose Vitamin D Completed NCT00977080 Phase 4 Paricalcitol;Cinacalcet
39 Efficacy and Safety of Alfacalcidol Compared to Calcitriol for Treatment of Secondary Hyperparathyroidism Completed NCT01115543 Phase 4 alfacalcidol and calcitriol
40 Effectiveness and Safety of IV Zemplar in Patients on Hemodialysis and With Secondary Hyperparathyroidism Using iPTH/100 as Initial Dose Completed NCT00891813 Phase 4 Zemplar (paricalcitol)
41 Paricalcitol Versus Calcitriol for Efficacy and Safety in Stage 3/4 Chronic Kidney Disease (CKD) With Secondary Hyperparathyroidism (SHPT) Completed NCT00823303 Phase 4 Paricalcitol;Calcitriol
42 20070360 Incident Dialysis Completed NCT00803712 Phase 4 Cinacalcet;Vitamin D
43 Vitamin D Deficiency in Chronic Kidney Disease (CKD) Patients Completed NCT00958451 Phase 4 Paricalcitol;Ergocalciferol
44 Does Treatment of Hypovitaminosis D Increase Calcium Absorption? Completed NCT00581828 Phase 4 Vitamin D
45 START: Sensipar Treatment Algorithm to Reach K/DOQI Targets in Chronic Kidney Disease Subjects With Secondary Hyperparathyroidism Completed NCT00132431 Phase 4 Sensipar
46 Characterization of Hyperparathyroidism and Vitamin D Deficiency in Obesity Completed NCT00288873 Phase 4 Ergocalciferol;Cholecalciferol
47 Osteopenia and Renal Osteodystrophy: Evaluation and Management Completed NCT00108394 Phase 4 pamidronate
48 Minimizing Narcotic Analgesics After Endocrine Surgery Recruiting NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
49 Study of the Effect of Recombinant Human Parathyroid Hormone [rhPTH(1-84)] on Symptoms Improvement and Metabolic Control Among Adults With Hypoparathyroidism Recruiting NCT03324880 Phase 4
50 Efficacy and Safety of Cinacalcet in Ca, P and iPTH Levels in Patients With Mild, Moderate and Severe SHPT Recruiting NCT03123406 Phase 4 Cinacalcet HCl

Search NIH Clinical Center for Parathyroid Gland Disease

Cochrane evidence based reviews: parathyroid diseases

Genetic Tests for Parathyroid Gland Disease

Genetic tests related to Parathyroid Gland Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Parathyroid Gland 29

Anatomical Context for Parathyroid Gland Disease

MalaCards organs/tissues related to Parathyroid Gland Disease:

Thyroid, Bone, Kidney, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Parathyroid Gland Disease:

The Parathyroid Gl

Publications for Parathyroid Gland Disease

Articles related to Parathyroid Gland Disease:

(show all 21)
# Title Authors Year
Metabolic Syndrome in Parathyroid Diseases. ( 29895021 )
Parathyroid Diseases and T Cells. ( 28421466 )
Sporadic multiple parathyroid gland disease-a consensus report of the European Society of Endocrine Surgeons (ESES). ( 26542689 )
Parathyroid diseases and animal models. ( 22754549 )
Overcoming obstacles to setting up office-based ultrasound for evaluation of thyroid and parathyroid diseases. ( 21305549 )
Molecular alterations in hereditary and sporadic thyroid and parathyroid diseases. ( 19098464 )
Animal models of hyperfunctioning parathyroid diseases for drug development. ( 23489166 )
The additional diagnostic value of a single-session combined scintigraphic and ultrasonographic examination in patients with thyroid and parathyroid diseases. ( 18927523 )
Mortality in sporadic primary hyperparathyroidism: nationwide cohort study of multiple parathyroid gland disease. ( 15523390 )
Minimally invasive surgery for thyroid and parathyroid diseases. ( 11961594 )
Endoscopic neck surgery: current status for thyroid and parathyroid diseases. ( 12487251 )
Video-assisted neck surgery for thyroid and parathyroid diseases. ( 12487261 )
Radionuclide scanning in parathyroid diseases. ( 9876061 )
Percutaneous ethanol injection therapy in the treatment of thyroid and parathyroid diseases. ( 9100545 )
Histopathological diagnosis of parathyroid diseases. ( 7479352 )
In situ correlation of synthesis and storage of parathormone in parathyroid gland disease. ( 8433215 )
Re: Diagnosis and management of parathyroid diseases. ( 1519177 )
Parathyroid gland disease and hypercalcemia. ( 2223448 )
Nuclear medicine in diagnosis and treatment of diseases of the head and neck. I. Salivary and parathyroid gland disease and one identification and staging of head and neck tumors. ( 6273364 )
Thyroid and parathyroid diseases. ( 7312364 )
Parathyroid diseases and irradiation. ( 4625857 )

Variations for Parathyroid Gland Disease

Copy number variations for Parathyroid Gland Disease from CNVD:

# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 160275 22 11800000 24300000 Microdeletion parathyroid gland dysfunction

Expression for Parathyroid Gland Disease

Search GEO for disease gene expression data for Parathyroid Gland Disease.

Pathways for Parathyroid Gland Disease

GO Terms for Parathyroid Gland Disease

Cellular components related to Parathyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.46 ADCY10 CALCA CASR RET
2 axon GO:0030424 9.26 ADCY10 CALCA CASR RET
3 endoplasmic reticulum lumen GO:0005788 8.92 ALB BGLAP FGF23 MEN1

Biological processes related to Parathyroid Gland Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.92 CDC73 MEN1 PTHLH VDR
2 cell-cell signaling GO:0007267 9.83 CALCA FGF3 PTH PTHLH
3 regulation of signaling receptor activity GO:0010469 9.83 CALCA FGF23 FGF3 PTH PTHLH
4 MAPK cascade GO:0000165 9.81 FGF23 FGF3 MEN1 RET
5 cellular protein metabolic process GO:0044267 9.76 ALB CALCA FGF23 MEN1
6 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.73 CALCA PTH PTHLH
7 skeletal system development GO:0001501 9.67 BGLAP PTH PTHLH VDR
8 decidualization GO:0046697 9.61 MEN1 VDR
9 regulation of bone mineralization GO:0030500 9.61 BGLAP FGF23
10 response to pain GO:0048265 9.6 CALCA RET
11 response to vitamin D GO:0033280 9.59 BGLAP PTH
12 vasodilation GO:0042311 9.58 CALCA CASR
13 negative regulation of chondrocyte differentiation GO:0032331 9.58 PTH PTHLH
14 bone mineralization GO:0030282 9.58 BGLAP PTH PTHLH
15 vitamin D metabolic process GO:0042359 9.55 FGF23 VDR
16 cellular phosphate ion homeostasis GO:0030643 9.54 FGF23 GCM2
17 phosphate ion homeostasis GO:0055062 9.49 FGF23 PTH
18 response to fibroblast growth factor GO:0071774 9.48 CASR PTH
19 osteoblast development GO:0002076 9.33 BGLAP MEN1 PTHLH
20 cAMP metabolic process GO:0046058 9.32 PTH PTHLH
21 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.26 FGF23 VDR
22 cellular response to vitamin D GO:0071305 9.13 BGLAP CASR FGF23
23 cellular calcium ion homeostasis GO:0006874 9.02 CALCA CASR GCM2 PTH VDR
24 positive regulation of transcription by RNA polymerase II GO:0045944 10.04 AIRE CDC73 GCM2 MEN1 PTH VDR

Molecular functions related to Parathyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 FGF23 FGF3 RET
2 fibroblast growth factor receptor binding GO:0005104 9.26 FGF23 FGF3
3 hormone activity GO:0005179 9.13 CALCA PTH PTHLH
4 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Parathyroid Gland Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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