MCID: PRT030
MIFTS: 45

Parathyroid Gland Disease

Categories: Endocrine diseases

Aliases & Classifications for Parathyroid Gland Disease

MalaCards integrated aliases for Parathyroid Gland Disease:

Name: Parathyroid Gland Disease 12 15
Parathyroid Diseases 43 71
Disease of Parathyroid Glands 12
Parathyroid Disease 17

Classifications:



External Ids:

Disease Ontology 12 DOID:11201
ICD9CM 34 252 252.9
MeSH 43 D010279
NCIt 49 C26844
SNOMED-CT 67 73132005
ICD10 32 E21.4 E21.5
UMLS 71 C0030517

Summaries for Parathyroid Gland Disease

Disease Ontology : 12 An endocrine system disease that is located in the parathyroid gland.

MalaCards based summary : Parathyroid Gland Disease, also known as parathyroid diseases, is related to hypoparathyroidism and multiple endocrine neoplasia. An important gene associated with Parathyroid Gland Disease is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Endocrine and other factor-regulated calcium reabsorption. The drugs Tramadol and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include parathyroid gland, thyroid and bone, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Wikipedia : 74 Many conditions are associated with disorders of the function of the parathyroid gland. Parathyroid... more...

Related Diseases for Parathyroid Gland Disease

Diseases related to Parathyroid Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 hypoparathyroidism 32.1 VDR RET PTHLH PTH GCM2 FGF23
2 multiple endocrine neoplasia 30.8 RET MEN1 CALCA
3 hyperparathyroidism 30.7 VDR TNFSF11 TNFRSF11B RET PTHLH PTH
4 hyperparathyroidism 1 30.7 MEN1 GCM2 CDC73
5 adenoma 30.7 RET PTH MEN1 CDC73 CASR
6 paraneoplastic syndromes 30.7 PTHLH FGF23
7 goiter 30.7 RET CALCA BGLAP
8 pseudohypoparathyroidism 30.7 PTHLH PTH CALCA BGLAP
9 hyperparathyroidism 2 with jaw tumors 30.6 RET MEN1 CDC73 CASR
10 thyroid gland disease 30.5 RET PTH CALCA ALB
11 thyroid gland medullary carcinoma 30.4 RET MEN1 GAST CALCA
12 multiple endocrine neoplasia, type iia 30.4 RET PTH MEN1 CDC73 CALCA
13 thyroid carcinoma, familial medullary 30.4 RET MEN1 GAST CALCA
14 graves disease 1 30.3 PTH CALCA ALB
15 parathyroid carcinoma 30.3 RET PTH MEN1 CDC73 CASR CALCA
16 uremia 30.2 VDR TNFRSF11B PTH MEN1 CASR ALB
17 metabolic acidosis 30.1 PTH FGF23 BGLAP ALB
18 spondyloarthropathy 1 30.0 TNFSF11 TNFRSF11B PTH BGLAP
19 hypothyroidism 30.0 TNFRSF11B RET CALCA BGLAP ALB AIRE
20 multiple endocrine neoplasia, type i 29.9 RET PTH MEN1 GAST CDC73 CASR
21 parathyroid adenoma 29.6 VDR RET PTHLH PTH MEN1 GCM2
22 rickets 29.5 VDR PTH KL FGF23 CYP27B1 CASR
23 hyperphosphatemia 29.5 VDR TNFRSF11B PTH KL GCM2 FGF23
24 hypophosphatemia 29.5 VDR PTHLH PTH KL FGF23 CYP27B1
25 secondary hyperparathyroidism 29.5 VDR TNFRSF11B PTH MEN1 KL FGF23
26 bone disease 29.3 VDR TNFSF11 TNFRSF11B PTHLH PTH FGF23
27 kidney disease 29.3 VDR TNFRSF11B RET PTH FGF23 CYP27B1
28 bone resorption disease 28.9 VDR TNFSF11 TNFRSF11B PTHLH PTH KL
29 primary hyperparathyroidism 28.6 VDR TNFSF11 TNFRSF11B RET PTHLH PTH
30 rare genetic parathyroid disease and phosphocalcic metabolism disorder 12.2
31 rare parathyroid disease and phosphocalcic metabolism anomaly 12.2
32 clear cell adenoma 10.7 PTH CDC73
33 parathyroid transitional clear cell adenoma 10.7 PTH MEN1
34 pediatric ovarian germ cell tumor 10.7 PTHLH PTH
35 pediatric ovarian dysgerminoma 10.7 PTHLH PTH
36 laryngeal neuroendocrine tumor 10.6 RET CALCA
37 hypocalciuric hypercalcemia, familial, type i 10.6 PTH CDC73 CASR
38 hypocalciuric hypercalcemia, familial, type ii 10.6 PTH CDC73 CASR
39 skin lipoma 10.6 RET MEN1
40 substernal goiter 10.6 PTH GCM2
41 tall cell variant papillary carcinoma 10.6 RET PTH
42 nonencapsulated sclerosing carcinoma 10.6 RET CALCA
43 oncogenic osteomalacia 10.6 PTHLH PTH FGF23
44 multiple endocrine neoplasia, type iv 10.6 RET MEN1 CDC73
45 multiple mucosal neuroma 10.6 RET MEN1 CALCA
46 bone benign neoplasm 10.6 PTH FGF23 CDC73
47 conjunctival deposit 10.6 KL FGF23
48 chief cell adenoma 10.6 PTH GCM2
49 gastrointestinal neuroendocrine benign tumor 10.6 MEN1 GAST
50 dental abscess 10.6 PTH KL FGF23

Graphical network of the top 20 diseases related to Parathyroid Gland Disease:



Diseases related to Parathyroid Gland Disease

Symptoms & Phenotypes for Parathyroid Gland Disease

MGI Mouse Phenotypes related to Parathyroid Gland Disease:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.4 AIRE ALB CASR CDC73 CYP27B1 FGF23
2 growth/size/body region MP:0005378 10.39 AIRE CASR CDC73 CYP27B1 FGF23 FGF3
3 immune system MP:0005387 10.36 AIRE ALB CASR CDC73 CYP27B1 FGF23
4 homeostasis/metabolism MP:0005376 10.35 AIRE ALB CASR CDC73 CYP27B1 FGF23
5 cellular MP:0005384 10.34 ALB CASR CDC73 CYP27B1 GCM2 KL
6 behavior/neurological MP:0005386 10.32 AIRE CASR CDC73 CYP27B1 FGF3 KL
7 digestive/alimentary MP:0005381 10.28 AIRE ALB CASR CDC73 FGF23 GAST
8 cardiovascular system MP:0005385 10.27 ALB CDC73 FGF23 KL MEN1 PTH
9 hematopoietic system MP:0005397 10.27 AIRE CASR CDC73 CYP27B1 FGF23 KL
10 mortality/aging MP:0010768 10.27 AIRE ALB CASR CDC73 FGF23 FGF3
11 craniofacial MP:0005382 10.25 CDC73 CYP27B1 GCM2 KL MEN1 PTH
12 limbs/digits/tail MP:0005371 10.14 CYP27B1 FGF23 FGF3 KL PRODH PTH
13 integument MP:0010771 10.09 CASR CDC73 CYP27B1 FGF23 KL PRODH
14 muscle MP:0005369 9.92 ALB CASR CDC73 KL MEN1 RET
15 neoplasm MP:0002006 9.86 AIRE ALB CDC73 GAST MEN1 PTHLH
16 renal/urinary system MP:0005367 9.85 ALB CASR CDC73 CYP27B1 FGF23 GCM2
17 reproductive system MP:0005389 9.7 AIRE CDC73 CYP27B1 FGF23 FGF3 KL
18 skeleton MP:0005390 9.44 CASR CDC73 CYP27B1 FGF23 FGF3 GCM2

Drugs & Therapeutics for Parathyroid Gland Disease

Drugs for Parathyroid Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
4
Codeine Approved, Illicit Phase 4 76-57-3 5284371
5 Central Nervous System Depressants Phase 4
6 Narcotics Phase 4
7 Antipyretics Phase 4
8 Analgesics, Non-Narcotic Phase 4
9 Analgesics, Opioid Phase 4
10 Antitussive Agents Phase 4
11 Respiratory System Agents Phase 4
12 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
13 Analgesics Phase 4
14
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
15
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
16
Choline Approved, Nutraceutical Phase 3 62-49-7 305
17
Calcifediol Approved, Nutraceutical Phase 3 19356-17-3 6433735 5283731
18
Calcitriol Approved, Nutraceutical Phase 3 32222-06-3 134070 5280453
19 Technetium Tc 99m Sestamibi Phase 3
20 Vitamins Phase 3
21 Calciferol Phase 3
22 Trace Elements Phase 3
23 1 alpha-hydroxyergocalciferol Phase 3
24 Micronutrients Phase 3
25 Ergocalciferols Phase 3
26 Nutrients Phase 3
27 Vitamin D2 Phase 3
28 Hypolipidemic Agents Phase 3
29 Gastrointestinal Agents Phase 3
30 Nootropic Agents Phase 3
31 Lipid Regulating Agents Phase 3
32 Antimetabolites Phase 3
33 Pharmaceutical Solutions Phase 2
34
Piperacillin Approved 66258-76-2 43672
35
Cefazolin Approved 25953-19-9 656510 33255
36
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
37
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
38
Pancrelipase Approved, Investigational 53608-75-6
39
Epinephrine Approved, Vet_approved 51-43-4 5816
40
Racepinephrine Approved 329-65-7 838
41
Ibuprofen Approved 15687-27-1 3672
42
Hydrocodone Approved, Illicit, Investigational 125-29-1 5284569
43
Oxycodone Approved, Illicit, Investigational 76-42-6 5284603
44
Parathyroid hormone Approved, Investigational 9002-64-6
45
Formaldehyde Approved, Vet_approved 50-00-0 712
46
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
47
Biotin Approved, Investigational, Nutraceutical 58-85-5 171548
48 Radiopharmaceuticals
49 Anti-Bacterial Agents
50 Anti-Infective Agents

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Minimizing Narcotic Analgesics After Thyroid or Parathyroid Surgery Recruiting NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
2 Clinical Value of 18F -Fluorocholine (18F-FCH) PET in Localizing Parathyroid Lesions: Comparison With 99mTc-sestamibi (MIBI) Scan. Completed NCT03555487 Phase 3 18F-choline PET
3 A Long-term Safety and Efficacy Study of CTAP101 Capsules in Subjects With Stages 3 or 4 Chronic Kidney Disease, Secondary Hyperparathyroidism and Vitamin D Insufficiency (Extension of Study CTAP101-CL-3001 or CTAP101-CL-3002) Completed NCT02282813 Phase 3 CTAP101 Capsules;Calcitriol;Doxercalciferol;Paricalcitol
4 A Randomized, Double Blind, Placebo-Controlled, Repeat Dose, Safety, Efficacy and Pharmacokinetic/Pharmacodynamic Study of CTAP101 Capsules in Subjects With Chronic Kidney Disease, Vitamin D Insufficiency and Secondary Hyperparathyroidism Completed NCT01219855 Phase 2, Phase 3 Cohort 1 CTAP101 Capsules- 60µg;Cohort 1 CTAP101 Capsules - 90µg;Cohort 1 Matching Sugar Capsule;Cohort 2 CTAP101 Capsules - 30µg;Cohort 2 Matching Sugar Capsule
5 A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Efficacy and Safety of CTAP101 Capsules to Treat Secondary Hyperparathyroidism in Subjects With Stage 3 or 4 Chronic Kidney Disease and Vitamin D Insufficiency Completed NCT01704079 Phase 3 CTAP101 30 μg capsules
6 A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Efficacy and Safety of CTAP101 Capsules to Treat Secondary Hyperparathyroidism in Subjects With Stage 3 or 4 Chronic Kidney Disease and Vitamin D Insufficiency Completed NCT01651000 Phase 3 CTAP101 30 μg capsules
7 Prevention of Laryngeal Reflexes in Minimal Invasive Parathyroid Surgery by the Use of Topical Lidocaine Withdrawn NCT00528502 Phase 3 Lidocaine;Saline
8 An Open Label, Four Week, Dose Escalating Pharmacokinetic, Pharmacodynamic, Efficacy and Safety Study of CTA018 Injection in Subjects With Stage 5 Chronic Kidney Disease With Secondary Hyperparathyroidism on Hemodialysis Completed NCT00742716 Phase 2 CTA018 Injection
9 PaTH Forward: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial With an Open-Label Extension, Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Subcutaneously Daily in Adults With Hypoparathyroidism Recruiting NCT04009291 Phase 2
10 Single-Dose, Two-Period, Open Label, Dose Determination, Randomized, Cross-Over Study of CTAP201 Injection and Doxercalciferol (Hectorol) Injection in Subjects With Stage 5 CKD and SHPT on Hemodialysis Completed NCT00792857 Phase 1 CTAP201 Injection;Doxercalciferol
11 A Randomized, Open-Label, Single-Dose Pilot Study of Oral and i.v. CTAP101 Evaluating PK and Safety in Stage 3 and 4 CKD Subjects With Vitamin D Insufficiency and SHPT Completed NCT00888069 Phase 1 CTAP101 Capsules;CTAP101 Injection
12 Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders Unknown status NCT00403598
13 Surgeon Compared to Nuclear Radiology Readers for Tc-99m Sestamibi Scans for Parathyroid Disease Completed NCT01545622
14 Antimicrobial Prophylaxis for the Prevention of Surgical Site Infection in Thyroid and Parathyroid Surgery Completed NCT01805856 PIPC piperacillin sodium;CEZ, cefazolin sodium
15 Amino Acid Transport Imaging of Parathyroid Adenomas With Anti-3-[18F]FACBC Completed NCT01574287 FACBC
16 A Pilot Study of Genetic Evaluation of Families With Endocrine Cancers Completed NCT01794676
17 Complications of Endocrine Surgery: Data From the United Health System Consortium Completed NCT01539499
18 Utility of the Urine Calcium Creatinine Ratio as a Screening Tool for Vitamin D Deficiency in Infants and Toddlers Completed NCT01105689
19 Nausea and Pain Prophylaxis During Thyroid Surgery, a Comparison of Low-Dose and High-Dose Dexamethasone to Placebo Completed NCT00569920 dexamethasone;natriumchloride 0,9%;dexamethasone
20 Interference of Biotin Supplementation in Biotin-streptavidin Platforms for Hormone Testing Completed NCT03034707
21 Burden of Illness and Disease Associated Emergencies in Chronic Hypoparathyroidism Completed NCT03437174
22 Study of the Efficacy and Safety on the Ultrasonic Ablation Treatment for Secondary Hyperthyroidism in Chronic Kidney Disease Patients. Completed NCT01640184 Active vitamin D
23 Phase 1 Study of Electrical Impedance Spectroscopy in Thyroid and Parathyroid Surgery Completed NCT02901873
24 Lower Vitamin D Levels During Second Trimester Are Associated With Developing Gestational Diabetes Mellitus: an Observational Cross-sectional Study Completed NCT03665974
25 Effect of Periodontitis on Bone Mineral Density in Postmenopausal Women Completed NCT02628197
26 Establishment of a Parathyroid Tissue Bank Recruiting NCT03051126
27 Comprehensive Data Collection and Follow-Up for Patients With Thyroid, Parathyroid and Adrenal Disease Recruiting NCT03050762
28 Are Narcotic Pain Medications Necessary Following Thyroidectomy and Parathyroidectomy Recruiting NCT03640247 Non-narcotic group regimen;Narcotic group regimen
29 Early Postoperative Serum Parathyroid Hormone Levels as a Predictor of Hypocalcaemia After Total Thyroidectomy: A Prospective Non-Randomized Study Recruiting NCT04160637
30 Relationship of Preoperative PTH and Ex-Vivo Gamma Counts in Minimally Invasive Parathyroidectomy Active, not recruiting NCT01539486
31 Serum Calcium to Phosphorous (Ca/P) Ratio in the Diagnosis of Ca-P Metabolism Disorders: a Multicentre Study Active, not recruiting NCT03747029
32 Gene Expression in Hyperparathyroidism: Identifying Molecular Differences in MEN1 Patients Versus Young MEN1 Negative Patients Terminated NCT03044600
33 Localization of Parathyroid Adenomas Using MRI and SPECT Fusion Software in Patients With Persistent or Recurrent Hyperparathyroidism Terminated NCT00639405

Search NIH Clinical Center for Parathyroid Gland Disease

Cochrane evidence based reviews: parathyroid diseases

Genetic Tests for Parathyroid Gland Disease

Anatomical Context for Parathyroid Gland Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Parathyroid Gland Disease:

19
Parathyroid Gland

MalaCards organs/tissues related to Parathyroid Gland Disease:

40
Thyroid, Bone, Kidney, Adrenal Gland, T Cells, Testes, Skin

Publications for Parathyroid Gland Disease

Articles related to Parathyroid Gland Disease:

(show top 50) (show all 130)
# Title Authors PMID Year
1
Fluorescent nanosensor for in situ detection of phosphate and alkaline phosphatase in mice with parathyroid dysfunction. 61
31995041 2020
2
Migraine without Aura and Subclinical Atherosclerosis in Young Females: Is Gut Microbiota to Blame? 61
31888137 2019
3
Video-assisted neck surgery (VANS) using a gasless lifting procedure for thyroid and parathyroid diseases: "The VANS method from A to Z". 61
31728730 2019
4
Association of Autofluorescence-Based Detection of the Parathyroid Glands During Total Thyroidectomy With Postoperative Hypocalcemia Risk: Results of the PARAFLUO Multicenter Randomized Clinical Trial. 61
31693081 2019
5
Parathyroid Diseases. 61
30921001 2019
6
Current concepts in parathyroid carcinoma: a single Centre experience. 61
31142320 2019
7
Management of brown tumor of spine with primary hyperparathyroidism: A case report and literature review. 61
30946329 2019
8
Study of the Ultrasound Appearance of the Normal Parathyroid Using an Intraoperative Procedure. 61
29802631 2019
9
Risk factors and prognosis of voice disorders after surgical treatment of thyroid and parathyroid diseases. 61
31120441 2019
10
[Trends in parathyroid hormone plasma concentration in critically ill patients: prospective observational study]. 61
30796860 2019
11
Metastases to the Parathyroid Glands: A Comprehensive Literature Review of 127 Reported Cases. 61
28875280 2018
12
Usefulness of preoperative ultrasonographic localization for diagnosis of a rare disease: Intrathyroid parathyroid lesions. 61
29879058 2018
13
Metabolic Syndrome in Parathyroid Diseases. 61
29895021 2018
14
Resource utilization associated with cervical hematoma after thyroid and parathyroid surgery. 61
28985879 2017
15
MULTIGLANDULAR PARATHYROID GLAND DISEASE: AN INCIDENTAL DISCOVERY IN NORMOCALCEMIC PATIENTS DURING THYROID SURGERY. 61
31149199 2017
16
Parathyroid Diseases and T Cells. 61
28421466 2017
17
Measurement of thyroglobulin, calcitonin, and PTH in FNA washout fluids. 61
27802177 2017
18
Toxic and Endocrine Myopathies. 61
27922495 2016
19
Sonography of Normal and Abnormal Thyroid and Parathyroid Glands. 61
27002829 2016
20
Sporadic multiple parathyroid gland disease--a consensus report of the European Society of Endocrine Surgeons (ESES). 61
26542689 2015
21
Ultrasensitive Impedimetric Biosensor Fabricated by a New Immobilisation Technique for Parathyroid Hormone. 61
25935225 2015
22
Parathyroid adenoma in patients with Graves' disease: a report of 21 cases. 61
25501495 2015
23
[Efficiency of (99)Tc(m)-sestamibi in diagnosis of parathyroid diseases with primary hyperparathyroidism]. 61
25916532 2015
24
Hypocalcaemia after total thyroidectomy: could intact parathyroid hormone be a predictive factor for transient postoperative hypocalcemia? 61
25616948 2015
25
Primary hyperparathyroidism during pregnancy. 61
25367603 2015
26
Vignette hyperparathyroidism: glimpse into its history. 61
25216416 2014
27
Incidence and risk factors for injuries to the recurrent laryngeal nerve during neck surgery in the moderate-volume setting. 61
24402457 2014
28
Is there a role for video-assisted parathyroidectomy in regions with high prevalence of goitre? 61
24376294 2013
29
[Minimally invasive video-assisted parathyroidectomy (MIVAP) using primary hyperparathyroidism therapy (pHPT)]. 61
24479514 2013
30
Location, number and morphology of parathyroid glands: results from a large anatomical series. 61
22689148 2012
31
Parathyroid diseases and animal models. 61
22754549 2012
32
Diseases of the parathyroid gland in chronic kidney disease. 61
21818548 2011
33
Gastrointestinal motility disorders in endocrine diseases. 61
21532535 2011
34
Overcoming obstacles to setting up office-based ultrasound for evaluation of thyroid and parathyroid diseases. 61
21305549 2011
35
Endocrine problems in pregnancy. 61
21081587 2011
36
The parathyroids and the gut. 61
20485190 2010
37
[Association between thyroid and parathyroid diseases]. 61
20646378 2010
38
Diagnostic pitfalls in parathyroid gland cytology. 61
20432729 2010
39
Validity of dual tracer 99mTc-tetrofosmin and 99mTc-pertechnetate subtraction parathyroid scintigraphy in patients with primary and secondary hyperparathyroidism. 61
20095513 2009
40
[Radio-guided parathyroidectomy]. 61
20109383 2009
41
Cinacalcet in hyperfunctioning parathyroid diseases. 61
19765257 2009
42
2009 EANM parathyroid guidelines. 61
19471928 2009
43
Animal models of hyperfunctioning parathyroid diseases for drug development. 61
23489166 2009
44
Postauricular and axillary approach endoscopic neck surgery: a new technique. 61
19198933 2009
45
Unique expression pattern of the EMT markers Snail, Twist and E-cadherin in benign and malignant parathyroid neoplasia. 61
19176646 2009
46
Post-operative care through tele-follow up visits in patients undergoing thyroidectomy and parathyroidectomy in a resource-constrained environment. 61
19246606 2009
47
Molecular alterations in hereditary and sporadic thyroid and parathyroid diseases. 61
19098464 2009
48
The additional diagnostic value of a single-session combined scintigraphic and ultrasonographic examination in patients with thyroid and parathyroid diseases. 61
18927523 2008
49
Minimally invasive thyroid and parathyroid surgery is not a question of length of the incision. 61
18716792 2008
50
Familial hyperparathyroidism: surgical outcome after 30 years of follow-up in three families with germline HRPT2 mutations. 54
18436011 2008

Variations for Parathyroid Gland Disease

Copy number variations for Parathyroid Gland Disease from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 160275 22 11800000 24300000 Microdeletion parathyroid gland dysfunction

Expression for Parathyroid Gland Disease

Search GEO for disease gene expression data for Parathyroid Gland Disease.

Pathways for Parathyroid Gland Disease

GO Terms for Parathyroid Gland Disease

Cellular components related to Parathyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.7 VDR PTH MEN1 GCM2 FGF23 CASR
2 extracellular region GO:0005576 9.7 TNFSF11 TNFRSF11B PTHLH PTH KL GAST
3 extracellular space GO:0005615 9.32 TNFSF11 TNFRSF11B PTHLH PTH KL GAST

Biological processes related to Parathyroid Gland Disease according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.13 VDR TNFSF11 PTH MEN1 GCM2 CDC73
2 negative regulation of cell proliferation GO:0008285 10 VDR PTHLH MEN1 CYP27B1 CDC73
3 cellular protein metabolic process GO:0044267 9.92 MEN1 FGF23 CALCA ALB
4 cell-cell signaling GO:0007267 9.91 PTHLH PTH FGF3 CALCA
5 MAPK cascade GO:0000165 9.89 RET MEN1 KL FGF3 FGF23
6 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.83 PTHLH PTH CALCA
7 ossification GO:0001503 9.82 TNFSF11 CASR BGLAP
8 cellular calcium ion homeostasis GO:0006874 9.81 VDR PTH GCM2 CASR
9 fibroblast growth factor receptor signaling pathway GO:0008543 9.8 KL FGF3 FGF23
10 positive regulation of protein kinase B signaling GO:0051897 9.77 TNFSF11 RET KL FGF3 FGF23
11 response to estrogen GO:0043627 9.75 TNFRSF11B CYP27B1 BGLAP
12 bone mineralization GO:0030282 9.72 PTHLH CYP27B1 BGLAP
13 positive regulation of keratinocyte differentiation GO:0045618 9.65 VDR CYP27B1
14 regulation of osteoclast differentiation GO:0045670 9.65 TNFSF11 BGLAP
15 decidualization GO:0046697 9.65 VDR MEN1 CYP27B1
16 negative regulation of bone resorption GO:0045779 9.64 TNFRSF11B CALCA
17 response to inorganic substance GO:0010035 9.63 TNFRSF11B BGLAP
18 response to magnesium ion GO:0032026 9.63 TNFRSF11B FGF23
19 regulation of bone mineralization GO:0030500 9.63 FGF23 CYP27B1 BGLAP
20 osteoblast development GO:0002076 9.61 PTHLH MEN1 BGLAP
21 response to fibroblast growth factor GO:0071774 9.6 PTH CASR
22 cellular phosphate ion homeostasis GO:0030643 9.59 GCM2 FGF23
23 response to vitamin D GO:0033280 9.58 PTH CYP27B1 BGLAP
24 phosphate ion homeostasis GO:0055062 9.57 PTH FGF23
25 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.56 KL FGF23
26 skeletal system development GO:0001501 9.55 VDR TNFRSF11B PTHLH PTH BGLAP
27 cAMP metabolic process GO:0046058 9.54 PTHLH PTH
28 vitamin D catabolic process GO:0042369 9.52 FGF23 CYP27B1
29 cellular response to vitamin D GO:0071305 9.5 FGF23 CASR BGLAP
30 vitamin D metabolic process GO:0042359 9.43 VDR FGF23 CYP27B1
31 calcium ion homeostasis GO:0055074 9.26 TNFSF11 PTH KL CYP27B1
32 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 8.8 VDR FGF23 CYP27B1

Molecular functions related to Parathyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.62 VDR TNFRSF11B RET CASR
2 peptide hormone receptor binding GO:0051428 9.26 PTHLH PTH
3 vitamin D binding GO:0005499 9.16 VDR KL
4 fibroblast growth factor receptor binding GO:0005104 9.13 KL FGF3 FGF23
5 hormone activity GO:0005179 9.02 PTHLH PTH KL GAST CALCA

Sources for Parathyroid Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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