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MCID: PRT002
MIFTS: 53

Paratyphoid Fever

Categories: Gastrointestinal diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Paratyphoid Fever

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MalaCards integrated aliases for Paratyphoid Fever:

Name: Paratyphoid Fever 12 77 60 45 15 17 74
Paratyphoid B Fever 12 74
Paratyphoid C Fever 12 74
Paratyphoid a Fever 12
Paratyphoid Fever a 12
Paratyphoid Fever B 12
Paratyphoid Fever C 12
Paratyphoid a 12
Paratyphoid B 12
Paratyphoid C 12
Paratyphoid 12

Characteristics:

Orphanet epidemiological data:

60
paratyphoid fever
Inheritance: Not applicable;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:3055
MeSH 45 D010284
ICD10 via Orphanet 35 A01.1 A01.2 A01.3 more
UMLS via Orphanet 75 C0030528
Orphanet 60 ORPHA443227
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Summaries for Paratyphoid Fever

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Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in intestine, has material basis in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted by ingestion of contaminated food. The infection has symptom fever, has symptom headache, has symptom abdominal pain, has symptom malaise, has symptom anorexia, has symptom constipation, has symptom rosy spots on the central body, has symptom non productive cough (in early stage of illness), has symptom bradycardia, and has symptom hepatosplenomegaly.

MalaCards based summary : Paratyphoid Fever, also known as paratyphoid b fever, is related to typhoid fever and salmonellosis, and has symptoms including constipation, fever and abdominal pain. An important gene associated with Paratyphoid Fever is IFNGR1 (Interferon Gamma Receptor 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and prostate, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Paratyphoid fever, also known simply as paratyphoid, is a bacterial infection caused by one of the three... more...

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Related Diseases for Paratyphoid Fever

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Diseases related to Paratyphoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 typhoid fever 32.5 CASP1 CRP IFNGR1
2 salmonellosis 31.8 CASP1 IFNGR1
3 dysentery 30.0 CRP IL1A
4 radiculopathy 10.1 IL1A IL1R1
5 immune deficiency disease 10.0 IFNGR1 IL1A
6 hepatitis 10.0
7 hepatitis b 10.0
8 ileitis 10.0
9 nephrotic syndrome 10.0
10 hepatitis a 10.0
11 biliary atresia 10.0
12 purpura 10.0
13 appendicitis 10.0
14 vasculitis 10.0
15 osteomyelitis 10.0 IFNGR1 IL1A
16 cinca syndrome 10.0 CASP1 IL1R1
17 cryopyrin-associated periodic syndrome 9.9 CRP IL1R1
18 schnitzler syndrome 9.9 CRP IL1R1
19 epidemic typhus 9.9
20 brucellosis 9.9
21 pertussis 9.9
22 epidural abscess 9.9
23 cholera 9.9
24 intestinal perforation 9.9
25 orchitis 9.9
26 splenic infarction 9.9
27 aortic aneurysm 9.9
28 spondylitis 9.9
29 anthrax disease 9.9
30 granulocytopenia 9.9
31 haemophilus influenzae 9.9
32 encephalopathy 9.9
33 streptococcal meningitis 9.9 CRP IL1R1
34 uveitis 9.9 IL1A IL1R1
35 hyper-igd syndrome 9.9 CRP TNFRSF1A
36 pericoronitis 9.9 CRP TNFRSF1A
37 rheumatic myocarditis 9.9 CRP IL1A
38 relapsing fever 9.9 CRP TNFRSF1A
39 post-transplant lymphoproliferative disease 9.8 IL1A IL1R1 TNFRSF1A
40 palindromic rheumatism 9.8 CRP TNFRSF1A
41 ulceroglandular tularemia 9.8 CASP1 CRP
42 pericardial effusion 9.8 CRP TNFRSF1A
43 pericarditis 9.8 CRP TNFRSF1A
44 familial cold autoinflammatory syndrome 1 9.8 CASP1 IL1R1 TNFRSF1A
45 juvenile rheumatoid arthritis 9.8 CRP IL1R1
46 leishmaniasis 9.8 IFNGR1 IL1A
47 bone inflammation disease 9.7 CRP IL1A
48 wells syndrome 9.7 CRP IL1R1 TNFRSF1A
49 adult-onset still's disease 9.7 CRP IL1R1 TNFRSF1A
50 chorioamnionitis 9.7 CRP IL1A IL1R1

Graphical network of the top 20 diseases related to Paratyphoid Fever:



Diseases related to Paratyphoid Fever
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Symptoms & Phenotypes for Paratyphoid Fever

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Symptoms:

12
  • • constipation
  • • fever
  • • abdominal pain
  • • anorexia
  • • headache
  • • hepatosplenomegaly
  • • bradycardia
  • • malaise
  • • rosy spots on the central body
  • • non productive cough (in early stage of illness)

GenomeRNAi Phenotypes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 CASP1 IL1A PRKN TNFRSF1A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 CASP1 IL1A PRKN TNFRSF1A

MGI Mouse Phenotypes related to Paratyphoid Fever:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 CASP1 CRP IFNGR1 IL1A IL1R1 PRKN
2 homeostasis/metabolism MP:0005376 9.87 CASP1 CRP IFNGR1 IL1A IL1R1 PRKN
3 immune system MP:0005387 9.73 CASP1 CRP IFNGR1 IL1A IL1R1 TNFRSF1A
4 integument MP:0010771 9.63 CASP1 IFNGR1 IL1A IL1R1 PRKN TNFRSF1A
5 neoplasm MP:0002006 9.35 CASP1 IFNGR1 IL1A IL1R1 TNFRSF1A
6 renal/urinary system MP:0005367 8.92 CASP1 IFNGR1 IL1R1 TNFRSF1A
Sources

Drugs & Therapeutics for Paratyphoid Fever

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Drugs for Paratyphoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 4,Phase 1,Phase 2
2 Vaccines Phase 4,Phase 1,Phase 2
3 Pharmaceutical Solutions Phase 1, Phase 2,Not Applicable
4 Soy Bean Phase 1, Phase 2,Phase 2
5 Lecithin Phase 1, Phase 2,Phase 2
6 Liver Extracts Phase 1, Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Completed NCT00131833 Phase 4
2 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Completed NCT00131820 Phase 4
3 Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Completed NCT00125047 Phase 4
4 Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Completed NCT00125008 Phase 4
5 TY800 Dose Escalation (Typhoid) Completed NCT00269295 Phase 1, Phase 2 Placebo
6 Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma Patient Completed NCT02338700 Phase 1, Phase 2
7 Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma Patient Completed NCT02338804 Phase 1, Phase 2
8 Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma Patient Completed NCT02338778 Phase 1, Phase 2
9 Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma Patient Completed NCT02338752 Phase 1, Phase 2
10 Understanding Paratyphoid Infection Active, not recruiting NCT02100397 Not Applicable
11 Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge Study Active, not recruiting NCT02192008 Not Applicable
12 Investigating Typhoid Fever Pathogenesis Active, not recruiting NCT03067961 Not Applicable

Search NIH Clinical Center for Paratyphoid Fever

Cochrane evidence based reviews: paratyphoid fever

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Genetic Tests for Paratyphoid Fever

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Anatomical Context for Paratyphoid Fever

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MalaCards organs/tissues related to Paratyphoid Fever:

42
Skin, Bone, Prostate, Testes, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Paratyphoid Fever:

20
Intestine
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Publications for Paratyphoid Fever

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Articles related to Paratyphoid Fever:

(show top 50) (show all 153)
# Title Authors Year
1
Loop-mediated isothermal amplification (LAMP) for paratyphoid fever - a proof-of-principle analysis. ( 30761564 )
2019
2
Salmonella Typhi outer membrane protein STIV is a potential candidate for vaccine development against typhoid and paratyphoid fever. ( 30952553 )
2019
3
Typhoid and Paratyphoid Fever - A Call to Action: Erratum. ( 31021958 )
2019
4
Seasonal dynamics of typhoid and paratyphoid fever. ( 29720736 )
2018
5
Typhoid and paratyphoid fever: a call to action. ( 30138141 )
2018
6
The Relationship Between Blood Sample Volume and Diagnostic Sensitivity of Blood Culture for Typhoid and Paratyphoid Fever: A Systematic Review and Meta-Analysis. ( 30307563 )
2018
7
ECG abnormalities in a patient with paratyphoid fever. ( 30376076 )
2018
8
Overview of the impact of Typhoid and Paratyphoid fever. Utility of Ty21a vaccine (Vivotif®). ( 28515625 )
2017
9
Review of current typhoid fever vaccines, cross-protection against paratyphoid fever, and the European guidelines. ( 28856924 )
2017
10
Increase in paratyphoid fever cases in Japanese travellers returning from Cambodia in 2013. ( 26169980 )
2016
11
Status of paratyphoid fever vaccine research and development. ( 27083427 )
2016
12
Six Cases of Paratyphoid Fever Due to Salmonella Paratyphi A in Travelers Returning from Myanmar Between July 2014 and August 2015. ( 27352874 )
2016
13
A Large-Scale Community-Based Outbreak of Paratyphoid Fever Caused by Hospital-Derived Transmission in Southern China. ( 26186586 )
2015
14
Recurrent paratyphoid fever A co-infected with hepatitis A reactivated chronic hepatitis B. ( 24884719 )
2014
15
Typhoid and paratyphoid fever. ( 24707582 )
2014
16
Psychosis in paratyphoid fever - a case report from Australia. ( 24820292 )
2014
17
Paratyphoid fever: splicing the global analyses. ( 24904229 )
2014
18
Spatiotemporal transmission and determinants of typhoid and paratyphoid fever in Hongta District, Yunnan Province, China. ( 23516653 )
2013
19
The application of the grey disaster model to forecast epidemic peaks of typhoid and paratyphoid fever in China. ( 23565260 )
2013
20
Association between the incidence of typhoid and paratyphoid fever and meteorological variables in Guizhou, China. ( 22490402 )
2012
21
Typhoid and paratyphoid fever in Western Sydney Local Health District, NSW, January-June 2011. ( 23043747 )
2012
22
Typhoid fever and paratyphoid fever: Systematic review to estimate global morbidity and mortality for 2010. ( 23198130 )
2012
23
Study of clinical profile and antibiotic sensitivity in paratyphoid Fever cases admitted at teaching hospital in South India. ( 24479019 )
2012
24
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 21975746 )
2011
25
WITHDRAWN: Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). ( 21975751 )
2011
26
Global trends in typhoid and paratyphoid Fever. ( 20014951 )
2010
27
Burden of typhoid and paratyphoid fever in a densely populated urban community, Dhaka, Bangladesh. ( 20236850 )
2010
28
Typhoid and paratyphoid fever - prevention in travellers. ( 21301658 )
2010
29
Yields from blood cultures of patients with suspected paratyphoid fever A. ( 24031492 )
2010
30
Study on blood cultures and bacteria counts in the blood of paratyphoid fever A patients. ( 19526258 )
2009
31
Epidemiology of typhoid and paratyphoid fever hospitalizations in Spain (1997-2005). ( 19276655 )
2009
32
Laboratory-based surveillance of paratyphoid fever in the United States: travel and antimicrobial resistance. ( 18422453 )
2008
33
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 18843659 )
2008
34
Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). ( 18843701 )
2008
35
Epidemiology of typhoid and paratyphoid fever in India. ( 19745523 )
2008
36
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. ( 17477815 )
2007
37
Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B. ( 17582564 )
2007
38
Comparisons of predictors for typhoid and paratyphoid fever in Kolkata, India. ( 17935611 )
2007
39
Deep-seated resistance in relapsed paratyphoid fever. ( 16652303 )
2006
40
PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever. ( 16734611 )
2006
41
Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia. ( 15837356 )
2005
42
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 15846718 )
2005
43
Epidemiology of typhoid and paratyphoid fever in Kathmandu: two years study and trends of antimicrobial resistance. ( 16082406 )
2005
44
Paratyphoid fever in Vellore, South India. ( 16105360 )
2005
45
Typhoid and paratyphoid fever. ( 16125594 )
2005
46
Typhoid and paratyphoid fever in travellers. ( 16183516 )
2005
47
Typhoid and paratyphoid fever. ( 16271634 )
2005
48
Typhoid and paratyphoid fever. ( 16271635 )
2005
49
Typhoid and paratyphoid fever. ( 16271636 )
2005
50
Risk factors for typhoid and paratyphoid fever in Jakarta, Indonesia. ( 15173152 )
2004
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Variations for Paratyphoid Fever

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Expression for Paratyphoid Fever

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Search GEO for disease gene expression data for Paratyphoid Fever.
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Pathways for Paratyphoid Fever

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Pathways related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.57 CASP1 CRP IFNGR1 IL1A IL1R1 PRKN
2
PEDF Induced Signaling 65
Show member pathways
 13.34 CASP1 IFNGR1 IL1A IL1R1 TNFRSF1A
3
Cytokine Signaling in Immune system 67
Show member pathways
 13.03 CASP1 IFNGR1 IL1A IL1R1 TNFRSF1A
4
PAK Pathway 65
Show member pathways
 12.99 CASP1 IL1A IL1R1 TNFRSF1A
5
IL-2 Pathway 65
Show member pathways
 12.9 IFNGR1 IL1A IL1R1 TNFRSF1A
6
Apoptosis Modulation and Signaling 1
Show member pathways
 12.52 CASP1 IL1R1 TNFRSF1A
7
MAPK signaling pathway 1 38
12.46 CASP1 IL1A IL1R1 TNFRSF1A
8
NF-KappaB Family Pathway 65
Show member pathways
 12.42 IL1A IL1R1 TNFRSF1A
9
4-1BB Pathway 65
Show member pathways
 12.36 IFNGR1 IL1A IL1R1 TNFRSF1A
10
Th17 cell differentiation 38
Show member pathways
 12.31 IFNGR1 IL1A IL1R1
11
TRAF Pathway 65
Show member pathways
 12.31 CASP1 IL1A IL1R1 TNFRSF1A
12
Toll Comparative Pathway 65
Show member pathways
 12.06 IFNGR1 IL1A IL1R1
13
IL-1 signaling pathway 1
Show member pathways
 12.05 CASP1 IL1A IL1R1
14
Apoptosis and survival Caspase cascade 23
Show member pathways
 12.01 CASP1 IL1A TNFRSF1A
15
Toxoplasmosis 38
Show member pathways
 12.01 IFNGR1 IL1A TNFRSF1A
16
Tuberculosis 38
11.97 IFNGR1 IL1A TNFRSF1A
17
Fluid shear stress and atherosclerosis 38
11.83 IL1A IL1R1 TNFRSF1A
18
Necroptosis 38
Show member pathways
 11.69 CASP1 IFNGR1 IL1A TNFRSF1A
19
NF-kappa B signaling pathway 38
11.64 IL1R1 TNFRSF1A
20
Hematopoietic cell lineage 38
11.63 IL1A IL1R1
21
Pertussis 38
11.51 CASP1 IL1A
22
Salmonella infection (KEGG) 38
11.48 CASP1 IFNGR1 IL1A
23
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.42 IL1A TNFRSF1A
24
Osteoclast differentiation 38
11.36 IFNGR1 IL1A IL1R1 TNFRSF1A
25
Cellular Transformation by HTLV1 65
Show member pathways
 11.29 IFNGR1 TNFRSF1A
26
Transcription_NF-kB signaling pathway 23
11.23 IL1A IL1R1 TNFRSF1A
27
Interleukin-10 signaling 67
11.12 IL1A IL1R1 TNFRSF1A
28
Immune response IFN gamma signaling pathway 23
Show member pathways
 11.03 CASP1 IFNGR1 IL1A IL1R1 TNFRSF1A
29
Hypertrophy Model 1
10.85 IL1A IL1R1
30
Interleukin-1 processing 67
10.25 CASP1 IL1A
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GO Terms for Paratyphoid Fever

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Biological processes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.54 CRP IL1A PRKN
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.43 CASP1 PRKN TNFRSF1A
3 cellular response to mechanical stimulus GO:0071260 9.4 CASP1 TNFRSF1A
4 interleukin-1-mediated signaling pathway GO:0070498 9.32 IL1A IL1R1
5 inflammatory response GO:0006954 9.26 CRP IL1A IL1R1 TNFRSF1A
6 positive regulation of tumor necrosis factor-mediated signaling pathway GO:1903265 9.16 CASP1 PRKN
7 cytokine-mediated signaling pathway GO:0019221 9.02 CASP1 IFNGR1 IL1A IL1R1 TNFRSF1A
Sources

Sources for Paratyphoid Fever

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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