MCID: PRT002
MIFTS: 55

Paratyphoid Fever

Categories: Gastrointestinal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Paratyphoid Fever

MalaCards integrated aliases for Paratyphoid Fever:

Name: Paratyphoid Fever 12 74 58 43 15 17 71
Paratyphoid B Fever 12 71
Paratyphoid C Fever 12 71
Paratyphoid Fever a 12 32
Paratyphoid Fever B 12 32
Paratyphoid Fever C 12 32
Paratyphoid a Fever 12
Paratyphoid a 12
Paratyphoid B 12
Paratyphoid C 12
Paratyphoid 12

Characteristics:

Orphanet epidemiological data:

58
paratyphoid fever
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:3055
MeSH 43 D010284
ICD10 via Orphanet 33 A01.1 A01.2 A01.3 more
UMLS via Orphanet 72 C0030528
Orphanet 58 ORPHA443227
UMLS 71 C0030528 C0343375 C0343376 more

Summaries for Paratyphoid Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in intestine, has material basis in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted by ingestion of contaminated food. The infection has symptom fever, has symptom headache, has symptom abdominal pain, has symptom malaise, has symptom anorexia, has symptom constipation, has symptom rosy spots on the central body, has symptom non productive cough (in early stage of illness), has symptom bradycardia, and has symptom hepatosplenomegaly.

MalaCards based summary : Paratyphoid Fever, also known as paratyphoid b fever, is related to salmonellosis and tetanus, and has symptoms including constipation, fever and abdominal pain. An important gene associated with Paratyphoid Fever is PRKN (Parkin RBR E3 Ubiquitin Protein Ligase), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include intestine, skin and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Paratyphoid fever, also known simply as paratyphoid, is a bacterial infection caused by one of the three... more...

Related Diseases for Paratyphoid Fever

Diseases related to Paratyphoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 346)
# Related Disease Score Top Affiliating Genes
1 salmonellosis 31.3 TNF SPI1 SLC11A1 IL1B IFNGR1 IFNG
2 tetanus 30.6 TNF IL1B IFNG CRP
3 meningitis 30.6 TNF IL1B IFNG CRP
4 schistosomiasis 30.6 TNF IL1A IFNGR1 IFNG
5 spondylitis 30.6 TNF IFNG CRP
6 dysentery 30.5 TNF IL1B IL1A CRP
7 stomatitis 30.5 TNF IL1B IFNG
8 aortitis 30.4 TNF CRP
9 prostatitis 30.3 TNF IL1B IL1A
10 typhoid fever 30.3 TNFRSF1A TNF SPI1 SLC11A1 IL1R1 IL1B
11 brucellosis 30.3 TNF SLC11A1 IFNG CRP
12 peritonitis 30.2 TNF IL1B IFNG CRP
13 leptospirosis 30.2 TNF IL1B IFNG CRP
14 appendicitis 30.2 TNF IL1B IFNG CRP
15 gastroenteritis 30.2 TNF IL1B IFNG CRP
16 aphthous stomatitis 30.1 TNF IL1B IL1A IFNG
17 bronchitis 30.1 TNF IL1B CRP
18 pyelonephritis 30.0 TNF IL1B IFNG CRP
19 pneumonia 30.0 TNF IL1B IFNG CRP
20 colitis 30.0 TNF IL1R1 IL1B IFNG
21 viral hepatitis 30.0 TNFRSF1A TNF IFNG CRP
22 toxic shock syndrome 29.9 TNF IL1R1 IL1B IFNG CRP
23 osteomyelitis 29.8 TNF IL1B IL1A IFNGR1 IFNG CASP1
24 bone inflammation disease 29.8 TNFRSF1A TNF IL1B IFNG CRP CASP1
25 leprosy 3 29.7 TNF SLC11A1 PRKN IL1B IFNG
26 osteoarthritis 29.6 TNF IL1R1 IL1B IL1A CRP
27 malaria 28.0 TNFRSF1A TNF IL1R1 IL1B IL1A IL12B
28 rare form of salmonellosis 10.9
29 drug reaction with eosinophilia and systemic symptoms 10.5 TNF CRP
30 interferon gamma, receptor 1, deficiency 10.5 IFNGR1 IFNG
31 polyarticular juvenile idiopathic arthritis 10.5 TNF IFNG
32 autoimmune myocarditis 10.5 TNF IFNG
33 axillary adenitis 10.5 IFNGR1 IFNG
34 spotted fever rickettsiosis 10.5 TNF IFNG
35 rheumatoid arthritis interstitial lung disease 10.5 TNF CRP
36 posterior scleritis 10.5 TNF CRP
37 chronic beryllium disease 10.5 TNF IFNG
38 cryopyrin-associated periodic syndrome 10.5 IL1R1 CRP
39 systemic onset juvenile idiopathic arthritis 10.5 TNF IL1B
40 pericardial tuberculosis 10.4 IFNG CRP
41 skeletal tuberculosis 10.4 IFNG CRP
42 palladium allergic contact dermatitis 10.4 TNF IL1B
43 kashin-beck disease 10.4 TNF IL1B
44 tuberculous peritonitis 10.4 IFNG CRP
45 louse-borne relapsing fever 10.4 TNF CRP
46 prosthetic joint infection 10.4 IL1B CRP
47 angelucci's syndrome 10.4 IL1B IFNG
48 neuroretinitis 10.4 IFNG CRP
49 renal infectious disease 10.4 CRP CASP1
50 soft tissue sarcoma 10.4 TNF IFNG

Graphical network of the top 20 diseases related to Paratyphoid Fever:



Diseases related to Paratyphoid Fever

Symptoms & Phenotypes for Paratyphoid Fever

Symptoms:

12
  • constipation
  • fever
  • abdominal pain
  • anorexia
  • headache
  • hepatosplenomegaly
  • bradycardia
  • malaise
  • rosy spots on the central body
  • non productive cough

GenomeRNAi Phenotypes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CASP1 IL1A IL1B PRKN TNF TNFRSF1A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CASP1 IL1A IL1B PRKN TNF TNFRSF1A

MGI Mouse Phenotypes related to Paratyphoid Fever:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 CASP1 CRP HGD IFNG IFNGR1 IL12B
2 cardiovascular system MP:0005385 10.24 CASP1 CRP IFNG IFNGR1 IL1A IL1B
3 immune system MP:0005387 10.21 CASP1 CRP HGD IFNG IFNGR1 IL12B
4 hematopoietic system MP:0005397 10.17 CASP1 IFNG IFNGR1 IL12B IL1A IL1B
5 craniofacial MP:0005382 10.02 IFNG IL12B IL1B IL1R1 SPI1 TNF
6 digestive/alimentary MP:0005381 10 CASP1 IFNG IFNGR1 IL12B SLC11A1 TNF
7 integument MP:0010771 9.97 CASP1 IFNG IFNGR1 IL1A IL1B IL1R1
8 mortality/aging MP:0010768 9.93 CASP1 CLPX IFNG IFNGR1 IL12B IL1B
9 liver/biliary system MP:0005370 9.8 HGD IFNG IFNGR1 IL1R1 SPI1 TNF
10 neoplasm MP:0002006 9.7 CASP1 IFNG IFNGR1 IL12B IL1A IL1B
11 skeleton MP:0005390 9.32 HGD IFNG IFNGR1 IL12B IL1B IL1R1

Drugs & Therapeutics for Paratyphoid Fever

Drugs for Paratyphoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Immunologic Factors Phase 4
3
Azithromycin Approved Phase 3 83905-01-5 55185 447043
4
Sulfamethoxazole Approved Phase 3 723-46-6 5329
5
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
6 Anti-Infective Agents Phase 3
7 Renal Agents Phase 3
8 Antimalarials Phase 3
9 Antiparasitic Agents Phase 3
10 Anti-Infective Agents, Urinary Phase 3
11 Antiprotozoal Agents Phase 3
12 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
13 Anti-Bacterial Agents Phase 3
14 Lecithin Phase 1, Phase 2
15 Soy Bean Phase 1, Phase 2
16 Pharmaceutical Solutions Phase 1, Phase 2
17 Liver Extracts Phase 1, Phase 2
18 Immunoglobulin G
19 Immunoglobulin M
20 Immunoglobulins
21 Antibodies

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Typhoid Vi Vaccine Effectiveness in a Population Older Than 5 Years of Age Living in an Endemic Area in Hechi, Guangxi, P.R. China: A Group-Randomized Controlled Demonstration Project Completed NCT00131833 Phase 4
2 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam. An Evaluation of Feasibility, Public Acceptability, Effectiveness and Cost-Effectiveness in Students Completed NCT00131820 Phase 4
3 Effectiveness of a Combined Vi Vaccination and Health Education Program on Reducing the Burden of Typhoid During Childhood: A Demonstration Project in Karachi Completed NCT00125047 Phase 4
4 Randomized Controlled Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever in Eastern Kolkata, West Bengal, India Completed NCT00125008 Phase 4
5 Parallel Group, Double Blinded, 1:1, Randomized Controlled Phase III Trial of Co-trimoxazole Versus Azithromycin for the Treatment of Undifferentiated Fever In Nepal Active, not recruiting NCT02773407 Phase 3 Azithromycin;Co-trimoxazole
6 Safety Issue and Efficacy Study of Combining Mix Vaccine and Standard Therapy in the Treatment of Prostate Carcinoma Patient Completed NCT02338700 Phase 1, Phase 2
7 A Randomized, Double-Blind, Placebo-Controlled, Dose Escalation, In-Patient Phase I/II Study to Determine the Safety and Immunogenicity of Ty800 in Healthy Adult Subjects Completed NCT00269295 Phase 1, Phase 2 Placebo
8 Safety Issue and Efficacy Study of Combining Mix Vaccine and Standard Therapy in the Treatment of Breast Carcinoma Patient Completed NCT02338804 Phase 1, Phase 2
9 Safety Issue and Efficacy Study of Combining Mix Vaccine and Standard Therapy in the Treatment of Hepatocyte Carcinoma Patient Completed NCT02338778 Phase 1, Phase 2
10 Safety Issue and Efficacy Study of Combining Mix Vaccine and Standard Therapy in the Treatment of Pancreatic Carcinoma Patient Completed NCT02338752 Phase 1, Phase 2
11 Phase I Trial of a Live Oral Salmonella Enterica Serovar Paratyphi A Vaccine Harboring Mutations in guaBA and clpX Completed NCT01129453 Phase 1
12 Development of a Human Model of Salmonella Enterica Serovar Paratyphi A Challenge in Healthy Adult Volunteers Unknown status NCT02100397
13 Evaluation of Rapid Diagnostic Tests (RDT) in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases (NTD) in Patients Presenting With Persistent Fever (≥1 Week) in Cambodia, Nepal, Democratic Republic of the Congo and Sudan Completed NCT01766830
14 Investigating the Mechanisms and Determinants of Systemic and Mucosal Immunity to Salmonella Typhi and Salmonella Paratyphi A in naïve and Previously Exposed Individuals - A Challenge and Rechallenge Study Active, not recruiting NCT02192008
15 Investigating the Role of Typhoid Toxin in the Pathogenesis of Enteric Fever: A Double-blinded, Randomised, Outpatient Human Challenge Study. Active, not recruiting NCT03067961

Search NIH Clinical Center for Paratyphoid Fever

Cochrane evidence based reviews: paratyphoid fever

Genetic Tests for Paratyphoid Fever

Anatomical Context for Paratyphoid Fever

The Foundational Model of Anatomy Ontology organs/tissues related to Paratyphoid Fever:

19
Intestine

MalaCards organs/tissues related to Paratyphoid Fever:

40
Skin, Liver, Lung, Bone, Testes, Prostate, Breast

Publications for Paratyphoid Fever

Articles related to Paratyphoid Fever:

(show top 50) (show all 437)
# Title Authors PMID Year
1
[Epidemiology profil of fever typhoid in Meknes (Morocco) 2013-2016]. 61
31917023 2020
2
Characterization and protective efficacy of a Salmonella pathogenicity island 2 (SPI2) mutant of Salmonella Paratyphi A. 61
31610219 2019
3
Attenuated Salmonella Typhimurium expressing Salmonella Paratyphoid A O-antigen induces protective immune responses against two Salmonella strains. 61
31874075 2019
4
Spatial and Temporal Patterns of Typhoid and Paratyphoid Fever Outbreaks: A Worldwide Review, 1990-2018. 61
31665782 2019
5
Pediatric travelers presenting to an Australian emergency department (2014-2015): A retrospective, cross-sectional analysis. 61
30395939 2019
6
Antimicrobial resistance and genetic diversity of Salmonella enterica from eggs. 61
31572578 2019
7
Loop-mediated isothermal amplification for paratyphoid fever - a proof-of-principle analysis. 61
30761564 2019
8
Typhoid and Paratyphoid Fever - A Call to Action: Erratum. 61
31021958 2019
9
Salmonella Typhi outer membrane protein STIV is a potential candidate for vaccine development against typhoid and paratyphoid fever. 61
30952553 2019
10
The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017. 61
30792131 2019
11
Invasive Salmonella infections among children in Bintulu, Sarawak, Malaysian Borneo: a 6-year retrospective review. 61
30999894 2019
12
Identifying different types of flood-sensitive diarrheal diseases from 2006 to 2010 in Guangxi, China. 61
30623882 2019
13
Epidemiology of Typhoid and Paratyphoid: Implications for Vaccine Policy. 61
30845325 2019
14
Incidence of Typhoid and Paratyphoid Fevers Among Adolescents and Adults in Yangon, Myanmar. 61
30845332 2019
15
Salmonella infections in Canadian children. 61
30833820 2019
16
Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal Salmonella Serovars. 61
31998292 2019
17
Myositis associated with Salmonella paratyphi A bacteremia appears to be common. 61
30911492 2019
18
Analysis of research intensity on infectious disease by disease burden reveals which infectious diseases are neglected by researchers. 61
30598444 2019
19
The Relationship Between Blood Sample Volume and Diagnostic Sensitivity of Blood Culture for Typhoid and Paratyphoid Fever: A Systematic Review and Meta-Analysis. 61
30307563 2018
20
Typhoid and paratyphoid fever: a call to action. 61
30138141 2018
21
Global Trends in Typhoidal Salmonellosis: A Systematic Review. 61
30047364 2018
22
Typhoid Fever: Way Forward. 61
30047361 2018
23
Introductory Article on Global Burden and Epidemiology of Typhoid Fever. 61
30047370 2018
24
The Burden of Typhoid Fever in South Africa: The Potential Impact of Selected Interventions. 61
30047360 2018
25
Typhoidal Salmonella Trends in Thailand. 61
30047363 2018
26
Pan-genome Analysis of Ancient and Modern Salmonella enterica Demonstrates Genomic Stability of the Invasive Para C Lineage for Millennia. 61
30033331 2018
27
Typhoidal Salmonella serovars: ecological opportunity and the evolution of a new pathovar. 61
29790924 2018
28
Breast abscess due to Salmonella paratyphi A : Case reports with review of literature. 61
29862156 2018
29
Vaccines for preventing typhoid fever. 61
29851031 2018
30
Seasonal dynamics of typhoid and paratyphoid fever. 61
29720736 2018
31
Isolation and Identification of <i>Salmonella paratyphi </i>from Enteric Fever Patients at Different Hospitals of Quetta City. 61
30724049 2018
32
Enteric fever among children: 50 cases in a French tertiary care centre. 61
30060197 2018
33
ECG abnormalities in a patient with paratyphoid fever. 61
30376076 2018
34
Molecular and Clinical Epidemiology of Salmonella Paratyphi A Isolated from Patients with Bacteremia in Nepal. 61
29016327 2017
35
[Spatial and temporal clustering characteristics of typhoid and paratyphoid fever and its change pattern in 3 provinces in southwestern China, 2001-2012]. 61
29141338 2017
36
Vertical transmission of Salmonella enterica serotype Paratyphi A leading to abortion. 61
29255611 2017
37
Review of current typhoid fever vaccines, cross-protection against paratyphoid fever, and the European guidelines. 61
28856924 2017
38
Spatio-temporal variations of typhoid and paratyphoid fevers in Zhejiang Province, China from 2005 to 2015. 61
28720886 2017
39
Salmonella Intracellular Lifestyles and Their Impact on Host-to-Host Transmission. 61
28730976 2017
40
[Surveillance data on typhoid fever and paratyphoid fever in 2015, China]. 61
28647977 2017
41
The Epidemiology of Childhood Salmonella Infections in Alberta, Canada. 61
28306338 2017
42
Infectious Diseases and Tropical Cyclones in Southeast China. 61
28481286 2017
43
Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model. 61
28158395 2017
44
Overview of the impact of Typhoid and Paratyphoid fever. Utility of Ty21a vaccine (Vivotif®). 61
28515625 2017
45
[An outbreak of paratyphoid fever in a county of Yunnan province, 2010-2011]. 61
28231666 2017
46
Self-reported infections during international travel and notifiable infections among returning international travellers, Sweden, 2009-2013. 61
28753671 2017
47
Antimicrobial Resistance of Salmonella enterica Serovars Typhi and Paratyphi Isolates from a General Hospital in Karawaci, Tangerang, Indonesia: A Five-Year Review. 61
28484494 2017
48
Antimicrobial susceptibility profile, treatment outcome and serotype distribution of clinical isolates of Salmonella enterica subspecies enterica: a 2-year study from Kerala, South India. 61
28352198 2017
49
Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study. 61
27812090 2016
50
Genomic analysis of Salmonella enterica serotype Paratyphi A during an outbreak in Cambodia, 2013-2015. 61
28348832 2016

Variations for Paratyphoid Fever

Expression for Paratyphoid Fever

Search GEO for disease gene expression data for Paratyphoid Fever.

Pathways for Paratyphoid Fever

Pathways related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 TNFRSF1A TNF SLC11A1 PRKN IL1R1 IL1B
2
Show member pathways
13.71 TNFRSF1A TNF IL1R1 IL1B IL1A IL12B
3
Show member pathways
13.58 TNFRSF1A TNF IL1R1 IL1B IL1A IL12B
4
Show member pathways
13.41 TNFRSF1A TNF IL1R1 IL1B IL1A IL12B
5
Show member pathways
13.34 TNFRSF1A TNF IL1R1 IL1B IL1A IL12B
6
Show member pathways
13.25 TNFRSF1A TNF IL1R1 IL1B IL1A IFNGR1
7
Show member pathways
13.17 TNFRSF1A TNF IL1B IL12B IFNGR1 IFNG
8
Show member pathways
12.94 TNFRSF1A TNF IL1R1 IL1B IFNGR1
9
Show member pathways
12.89 TNF IL1B IL1A IL12B IFNG
10 12.85 TNFRSF1A TNF IL1B IL12B IFNGR1 IFNG
11 12.81 TNFRSF1A TNF IL1R1 IL1B IL1A CASP1
12
Show member pathways
12.8 TNF IL1B IL12B IFNG CASP1
13
Show member pathways
12.79 TNFRSF1A TNF IL1B IL1A IL12B IFNGR1
14
Show member pathways
12.75 TNFRSF1A TNF IL1R1 IL1B IL1A
15
Show member pathways
12.71 TNFRSF1A TNF IL1R1 IL1B IL1A IFNGR1
16
Show member pathways
12.68 TNFRSF1A TNF IL12B IFNGR1 IFNG
17
Show member pathways
12.65 TNF IL1B IL1A IFNGR1 IFNG
18 12.62 TNFRSF1A TNF SPI1 IL1B IFNG
19
Show member pathways
12.62 TNF IL1R1 IL1B IL1A IL12B IFNGR1
20
Show member pathways
12.59 TNFRSF1A TNF IL1R1 IL1B IL1A IL12B
21 12.44 TNFRSF1A TNF IL1R1 IL1B CASP1
22 12.38 TNFRSF1A TNF SPI1 IL1R1
23
Show member pathways
12.38 TNF IL1B IFNG CRP
24 12.37 TNFRSF1A TNF IL1R1 IL1B CASP1
25
Show member pathways
12.35 IL1R1 IL1B IL1A CASP1
26
Show member pathways
12.32 TNF IL1B IL1A IL12B IFNG
27
Show member pathways
12.27 TNF IL1R1 IL1B IL1A
28
Show member pathways
12.27 TNFRSF1A TNF IL1A CASP1
29
Show member pathways
12.27 TNF IL1R1 IL1B IFNGR1 IFNG
30
Show member pathways
12.26 TNF IL1B IL12B CASP1
31 12.24 TNFRSF1A TNF IFNGR1 IFNG
32
Show member pathways
12.24 TNF SPI1 IL1R1 IL1B IL1A IFNGR1
33
Show member pathways
12.19 TNFRSF1A TNF IL1B IL1A IL12B IFNGR1
34 12.12 TNFRSF1A TNF IL1B IL1A IL12B IFNGR1
35 12.08 TNF IL1R1 IL1B IL1A IFNG
36 12.08 TNFRSF1A TNF IL1R1 IL1B IL1A IFNG
37 12.06 TNF IL1B IL1A IL12B
38
Show member pathways
12.05 IL1R1 IL1B IL12B IFNG
39
Show member pathways
12.04 TNFRSF1A TNF IL1B IL1A IFNGR1 IFNG
40
Show member pathways
12.02 TNF IL1R1 IL1B IL12B IFNGR1 IFNG
41 12 TNFRSF1A TNF IL1R1 IL1B
42 11.99 TNF IL1R1 IL1B IL12B IFNG
43 11.98 TNF IL1R1 IL1B IL1A
44 11.95 IL1B IL1A IFNG
45 11.95 TNF IL1B IL1A IFNG
46
Show member pathways
11.93 IL1B IFNGR1 IFNG CASP1
47 11.92 TNF IL1B IL1A
48 11.86 IL1B IL1A IFNGR1 IFNG CASP1
49 11.85 TNF SPI1 IL1R1 IL1B IFNG
50 11.83 TNF SPI1 IL1B IFNG

GO Terms for Paratyphoid Fever

Biological processes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.17 TNFRSF1A TNF SPI1 SLC11A1 PRKN IL1B
2 immune response GO:0006955 10.05 TNF SLC11A1 IL1R1 IL1B IL1A IFNG
3 cell surface receptor signaling pathway GO:0007166 9.96 TNFRSF1A IL1R1 IL12B IFNG
4 inflammatory response GO:0006954 9.95 TNFRSF1A TNF SLC11A1 IL1R1 IL1B IL1A
5 cellular response to lipopolysaccharide GO:0071222 9.91 TNF IL1B IL1A IL12B CASP1
6 response to virus GO:0009615 9.88 TNF IFNGR1 IFNG
7 interleukin-1-mediated signaling pathway GO:0070498 9.87 IL1R1 IL1B IL1A
8 positive regulation of JNK cascade GO:0046330 9.86 TNF IL1B IL1A
9 regulation of inflammatory response GO:0050727 9.86 TNF IL1R1 CASP1
10 positive regulation of inflammatory response GO:0050729 9.86 TNFRSF1A TNF IL1B IL12B
11 cellular response to mechanical stimulus GO:0071260 9.85 TNFRSF1A IL1B CASP1
12 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.85 TNFRSF1A TNF PRKN IL1B IL1A CASP1
13 regulation of insulin secretion GO:0050796 9.83 TNF IL1B IFNG
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 TNFRSF1A TNF IL12B IFNG
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.82 TNF IL1B IL12B
16 positive regulation of interleukin-6 production GO:0032755 9.82 TNF IL1B IL1A
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 TNF IL1B IFNG
18 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.79 TNF IL1B IL1A
19 microglial cell activation GO:0001774 9.77 TNF IFNGR1 IFNG
20 positive regulation of phagocytosis GO:0050766 9.76 TNF SLC11A1 IL1B IFNG
21 positive regulation of gene expression GO:0010628 9.76 TNF SLC11A1 PRKN IL1B IL1A IFNGR1
22 positive regulation of osteoclast differentiation GO:0045672 9.74 TNF IL12B IFNG
23 positive regulation of amyloid-beta formation GO:1902004 9.72 TNF IFNGR1 IFNG
24 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.71 TNF IL1B
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 TNF IL1B IFNG
26 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.7 IL1B IL1A
27 negative regulation of interleukin-17 production GO:0032700 9.7 IL12B IFNG
28 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.7 IFNGR1 IFNG
29 positive regulation of neuroinflammatory response GO:0150078 9.69 TNF IL1B
30 positive regulation of ceramide biosynthetic process GO:2000304 9.69 TNFRSF1A TNF
31 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.69 IL1B IL12B
32 positive regulation of tumor necrosis factor-mediated signaling pathway GO:1903265 9.68 PRKN CASP1
33 positive regulation of smooth muscle cell apoptotic process GO:0034393 9.67 IL12B IFNG
34 negative regulation of lipid storage GO:0010888 9.67 TNF CRP
35 positive regulation of T-helper 1 type immune response GO:0002827 9.67 SLC11A1 IL12B
36 positive regulation of chemokine biosynthetic process GO:0045080 9.67 TNF IL1B IFNG
37 death-inducing signaling complex assembly GO:0071550 9.66 TNFRSF1A TNF
38 ectopic germ cell programmed cell death GO:0035234 9.65 IL1B IL1A
39 negative regulation of amyloid-beta clearance GO:1900222 9.65 TNF IFNGR1 IFNG
40 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.64 IL1R1 IL1B
41 positive regulation of fever generation GO:0031622 9.63 TNF IL1B
42 sequestering of triglyceride GO:0030730 9.62 TNF IL1B
43 fever generation GO:0001660 9.61 IL1B IL1A
44 regulation of establishment of endothelial barrier GO:1903140 9.61 TNFRSF1A TNF IL1B
45 positive regulation of vitamin D biosynthetic process GO:0060557 9.59 TNF IFNG
46 positive regulation of nitrogen compound metabolic process GO:0051173 9.58 TNF IFNG
47 astrocyte activation GO:0048143 9.56 TNF IL1B IFNGR1 IFNG
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.5 TNF IL1B IFNG
49 positive regulation of interferon-gamma production GO:0032729 9.35 TNF SLC11A1 IL1R1 IL1B IL12B
50 cytokine-mediated signaling pathway GO:0019221 9.23 TNFRSF1A TNF IL1R1 IL1B IL1A IL12B

Molecular functions related to Paratyphoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.56 TNF PRKN NPL IL12B HGD GALE
2 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1A
3 cytokine activity GO:0005125 9.02 TNF IL1B IL1A IL12B IFNG

Sources for Paratyphoid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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