MCID: PRT002
MIFTS: 54

Paratyphoid Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Paratyphoid Fever

MalaCards integrated aliases for Paratyphoid Fever:

Name: Paratyphoid Fever 12 76 59 44 15 73
Paratyphoid B Fever 12 73
Paratyphoid C Fever 12 73
Paratyphoid a Fever 12
Paratyphoid Fever a 12
Paratyphoid Fever B 12
Paratyphoid Fever C 12
Paratyphoid a 12
Paratyphoid B 12
Paratyphoid C 12
Paratyphoid 12

Characteristics:

Orphanet epidemiological data:

59
paratyphoid fever
Inheritance: Not applicable;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:3055
MeSH 44 D010284
Orphanet 59 ORPHA443227
ICD10 via Orphanet 34 A01.1 A01.2 A01.3 more
UMLS via Orphanet 74 C0030528

Summaries for Paratyphoid Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in intestine, has material basis in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted by ingestion of contaminated food. The infection has symptom fever, has symptom headache, has symptom abdominal pain, has symptom malaise, has symptom anorexia, has symptom constipation, has symptom rosy spots on the central body, has symptom non productive cough (in early stage of illness), has symptom bradycardia, and has symptom hepatosplenomegaly.

MalaCards based summary : Paratyphoid Fever, also known as paratyphoid b fever, is related to typhoid fever and salmonellosis, and has symptoms including fever, headache and abdominal pain. An important gene associated with Paratyphoid Fever is IFNGR1 (Interferon Gamma Receptor 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include intestine, skin and prostate, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Paratyphoid fever, also known simply as paratyphoid, is a bacterial infection caused by one of the three... more...

Related Diseases for Paratyphoid Fever

Graphical network of the top 20 diseases related to Paratyphoid Fever:



Diseases related to Paratyphoid Fever

Symptoms & Phenotypes for Paratyphoid Fever

Symptoms:

12
  • fever
  • headache
  • abdominal pain
  • malaise
  • anorexia
  • constipation
  • rosy spots on the central body
  • non productive cough (in early stage of illness)
  • bradycardia
  • hepatosplenomegaly

GenomeRNAi Phenotypes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 PRKN TNFRSF1A CASP1 IL1A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 IL1A PRKN TNFRSF1A CASP1

MGI Mouse Phenotypes related to Paratyphoid Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.95 PRKN IFNGR1 TNFRSF1A IL12B IL1A IL1R1
2 cardiovascular system MP:0005385 9.93 PRKN IFNGR1 TNFRSF1A IL1A IL1R1 CASP1
3 hematopoietic system MP:0005397 9.91 IFNGR1 TNFRSF1A IL12B IL1A IL1R1 CASP1
4 immune system MP:0005387 9.85 IFNGR1 TNFRSF1A IL12B IL1A IL1R1 CASP1
5 integument MP:0010771 9.8 PRKN IFNGR1 TNFRSF1A IL1A IL1R1 CASP1
6 neoplasm MP:0002006 9.73 IFNGR1 TNFRSF1A IL12B IL1A IL1R1 CASP1
7 renal/urinary system MP:0005367 9.46 IFNGR1 TNFRSF1A IL1R1 CASP1
8 respiratory system MP:0005388 9.26 PRKN IL12B TNFRSF1A IL1R1
9 skeleton MP:0005390 9.02 PRKN IFNGR1 TNFRSF1A IL12B IL1R1

Drugs & Therapeutics for Paratyphoid Fever

Drugs for Paratyphoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 1,Phase 2
2 Pharmaceutical Solutions Phase 1, Phase 2,Not Applicable
3 Liver Extracts Phase 1, Phase 2
4 Lecithin Nutraceutical Phase 1, Phase 2,Phase 2
5 Soy Bean Nutraceutical Phase 1, Phase 2,Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Completed NCT00131833 Phase 4
2 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Completed NCT00131820 Phase 4
3 Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Completed NCT00125047 Phase 4
4 Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Completed NCT00125008 Phase 4
5 TY800 Dose Escalation (Typhoid) Completed NCT00269295 Phase 1, Phase 2 Placebo
6 Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma Patient Completed NCT02338700 Phase 1, Phase 2
7 Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma Patient Completed NCT02338804 Phase 1, Phase 2
8 Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma Patient Completed NCT02338778 Phase 1, Phase 2
9 Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma Patient Completed NCT02338752 Phase 1, Phase 2
10 Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge Study Recruiting NCT02192008 Not Applicable
11 Understanding Paratyphoid Infection Active, not recruiting NCT02100397 Not Applicable
12 Investigating Typhoid Fever Pathogenesis Active, not recruiting NCT03067961 Not Applicable

Search NIH Clinical Center for Paratyphoid Fever

Cochrane evidence based reviews: paratyphoid fever

Genetic Tests for Paratyphoid Fever

Anatomical Context for Paratyphoid Fever

The Foundational Model of Anatomy Ontology organs/tissues related to Paratyphoid Fever:

19
Intestine

MalaCards organs/tissues related to Paratyphoid Fever:

41
Skin, Prostate, Liver, Testes, Bone, Bone Marrow

Publications for Paratyphoid Fever

Articles related to Paratyphoid Fever:

(show top 50) (show all 135)
# Title Authors Year
1
Seasonal dynamics of typhoid and paratyphoid fever. ( 29720736 )
2018
2
Review of current typhoid fever vaccines, cross-protection against paratyphoid fever, and the European guidelines. ( 28856924 )
2017
3
Overview of the impact of Typhoid and Paratyphoid fever. Utility of Ty21a vaccine (VivotifAr). ( 28515625 )
2017
4
Six Cases of Paratyphoid Fever Due to Salmonella Paratyphi A in Travelers Returning from Myanmar Between July 2014 and August 2015. ( 27352874 )
2016
5
Status of paratyphoid fever vaccine research and development. ( 27083427 )
2016
6
Increase in paratyphoid fever cases in Japanese travellers returning from Cambodia in 2013. ( 26169980 )
2015
7
A Large-Scale Community-Based Outbreak of Paratyphoid Fever Caused by Hospital-Derived Transmission in Southern China. ( 26186586 )
2015
8
Typhoid and paratyphoid fever. ( 24707582 )
2014
9
Recurrent paratyphoid fever A co-infected with hepatitis A reactivated chronic hepatitis B. ( 24884719 )
2014
10
Paratyphoid fever: splicing the global analyses. ( 24904229 )
2014
11
Psychosis in paratyphoid fever - a case report from Australia. ( 24820292 )
2014
12
Spatiotemporal transmission and determinants of typhoid and paratyphoid fever in Hongta District, Yunnan Province, China. ( 23516653 )
2013
13
Correction: The Application of the Grey Disaster Model to Forecast Epidemic Peaks of Typhoid and Paratyphoid Fever in China. ( 24039655 )
2013
14
The application of the grey disaster model to forecast epidemic peaks of typhoid and paratyphoid fever in China. ( 23565260 )
2013
15
Typhoid and paratyphoid fever in Western Sydney Local Health District, NSW, January-June 2011. ( 23043747 )
2012
16
Association between the incidence of typhoid and paratyphoid fever and meteorological variables in Guizhou, China. ( 22490402 )
2012
17
Typhoid fever and paratyphoid fever: Systematic review to estimate global morbidity and mortality for 2010. ( 23198130 )
2012
18
Study of clinical profile and antibiotic sensitivity in paratyphoid Fever cases admitted at teaching hospital in South India. ( 24479019 )
2012
19
WITHDRAWN: Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). ( 21975751 )
2011
20
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 21975746 )
2011
21
Global trends in typhoid and paratyphoid Fever. ( 20014951 )
2010
22
Typhoid and paratyphoid fever - prevention in travellers. ( 21301658 )
2010
23
Burden of typhoid and paratyphoid fever in a densely populated urban community, Dhaka, Bangladesh. ( 20236850 )
2010
24
Yields from blood cultures of patients with suspected paratyphoid fever A. ( 24031492 )
2010
25
Study on blood cultures and bacteria counts in the blood of paratyphoid fever A patients. ( 19526258 )
2009
26
Epidemiology of typhoid and paratyphoid fever hospitalizations in Spain (1997-2005). ( 19276655 )
2009
27
Epidemiology of typhoid and paratyphoid fever in India. ( 19745523 )
2008
28
Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). ( 18843701 )
2008
29
Laboratory-based surveillance of paratyphoid fever in the United States: travel and antimicrobial resistance. ( 18422453 )
2008
30
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 18843659 )
2008
31
Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B. ( 17582564 )
2007
32
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. ( 17477815 )
2007
33
Comparisons of predictors for typhoid and paratyphoid fever in Kolkata, India. ( 17935611 )
2007
34
Deep-seated resistance in relapsed paratyphoid fever. ( 16652303 )
2006
35
PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever. ( 16734611 )
2006
36
Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia. ( 15837356 )
2005
37
Typhoid and paratyphoid fever in travellers. ( 16183516 )
2005
38
Typhoid and paratyphoid fever. ( 16271636 )
2005
39
Typhoid and paratyphoid fever. ( 16125594 )
2005
40
Epidemiology of typhoid and paratyphoid fever in Kathmandu: two years study and trends of antimicrobial resistance. ( 16082406 )
2005
41
Paratyphoid fever in Vellore, South India. ( 16105360 )
2005
42
Typhoid and paratyphoid fever. ( 16271635 )
2005
43
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 15846718 )
2005
44
Risk factors for typhoid and paratyphoid fever in Jakarta, Indonesia. ( 15173152 )
2004
45
LipschA1tz genital ulceration: a rare manifestation of paratyphoid fever. ( 12804994 )
2003
46
An unusual paratyphoid fever. ( 11762624 )
2001
47
Typhoid and paratyphoid fever: a 10-year retrospective study of 41 cases in a Parisian hospital. ( 11726293 )
2001
48
Typhoid and paratyphoid fever in south-eastern Sydney, 1992-1997. ( 11022389 )
2000
49
Oral administration of fluoroquinolones in the treatment of typhoid fever and paratyphoid fever in Japan. ( 11197787 )
2000
50
Epidemiological studies of an outbreak of paratyphoid fever in the Shima area of Mie Prefecture. ( 10738368 )
1999

Variations for Paratyphoid Fever

Expression for Paratyphoid Fever

Search GEO for disease gene expression data for Paratyphoid Fever.

Pathways for Paratyphoid Fever

Pathways related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CASP1 IFNGR1 IL12B IL1A IL1R1 PRKN
2
Show member pathways
13.38 CASP1 IFNGR1 IL12B IL1A IL1R1 TNFRSF1A
3
Show member pathways
13.25 IFNGR1 IL12B IL1A IL1R1 TNFRSF1A
4
Show member pathways
13.05 CASP1 IL12B IL1A IL1R1 TNFRSF1A
5
Show member pathways
13.04 CASP1 IFNGR1 IL12B IL1A IL1R1 TNFRSF1A
6
Show member pathways
12.8 CASP1 IFNGR1 IL12B TNFRSF1A
7
Show member pathways
12.67 IFNGR1 IL12B IL1A TNFRSF1A
8
Show member pathways
12.59 IFNGR1 IL1A IL1R1 TNFRSF1A
9
Show member pathways
12.55 CASP1 IL1R1 TNFRSF1A
10 12.54 CASP1 IL1A IL1R1 TNFRSF1A
11
Show member pathways
12.46 IL1A IL1R1 TNFRSF1A
12
Show member pathways
12.44 IFNGR1 IL1A IL1R1 TNFRSF1A
13
Show member pathways
12.42 IFNGR1 IL12B IL1A
14
Show member pathways
12.41 CASP1 IFNGR1 IL12B IL1A TNFRSF1A
15
Show member pathways
12.22 IFNGR1 IL12B IL1A IL1R1
16
Show member pathways
12.12 CASP1 IL1A IL1R1
17
Show member pathways
12.08 IFNGR1 IL12B IL1R1
18
Show member pathways
12.08 IFNGR1 IL1A IL1R1
19
Show member pathways
12.03 CASP1 IL1A TNFRSF1A
20
Show member pathways
12.01 IFNGR1 IL12B IL1A TNFRSF1A
21 11.96 IFNGR1 IL12B IL1A TNFRSF1A
22 11.92 IL1A IL1R1 TNFRSF1A
23
Show member pathways
11.91 CASP1 IFNGR1 IL1A TNFRSF1A
24
Show member pathways
11.89 CASP1 IL12B IL1A IL1R1 TNFRSF1A
25 11.67 IFNGR1 IL1A IL1R1 TNFRSF1A
26 11.63 CASP1 IFNGR1 IL1A
27 11.57 CASP1 IL12B IL1A
28
Show member pathways
11.46 IL1A TNFRSF1A
29 11.4 CASP1 IL12B
30 11.39 IL1A IL1R1 TNFRSF1A
31
Show member pathways
11.35 IFNGR1 TNFRSF1A
32 11.15 IL12B IL1A IL1R1 TNFRSF1A
33 11.12 IL12B IL1A
34
Show member pathways
11.11 CASP1 IFNGR1 IL12B IL1A IL1R1 TNFRSF1A
35 10.92 IL1A IL1R1
36 10.39 CASP1 IL1A

GO Terms for Paratyphoid Fever

Cellular components related to Paratyphoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 CASP1 IL12B IL1A IL1R1 TNFRSF1A

Biological processes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.7 IL1A IL1R1 TNFRSF1A
2 regulation of apoptotic process GO:0042981 9.58 CASP1 PRKN TNFRSF1A
3 cellular response to interferon-gamma GO:0071346 9.54 CASP1 IL12B
4 cell surface receptor signaling pathway GO:0007166 9.54 IL12B IL1R1 TNFRSF1A
5 regulation of inflammatory response GO:0050727 9.51 CASP1 IL1R1
6 cellular response to mechanical stimulus GO:0071260 9.49 CASP1 TNFRSF1A
7 positive regulation of inflammatory response GO:0050729 9.48 IL12B TNFRSF1A
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 IL12B TNFRSF1A
9 regulation of autophagy GO:0010506 9.43 CASP1 PRKN
10 positive regulation of cytokine secretion GO:0050715 9.32 CASP1 IL1A
11 positive regulation of tumor necrosis factor-mediated signaling pathway GO:1903265 9.26 CASP1 PRKN
12 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.26 CASP1 IL1A PRKN TNFRSF1A
13 positive regulation of neutrophil extravasation GO:2000391 9.16 IL1A IL1R1
14 cytokine-mediated signaling pathway GO:0019221 9.1 CASP1 IFNGR1 IL12B IL1A IL1R1 TNFRSF1A

Molecular functions related to Paratyphoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.26 CASP1 IL12B PRKN TNFRSF1A
2 cytokine receptor activity GO:0004896 8.62 IFNGR1 IL12B

Sources for Paratyphoid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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