MCID: PRN006
MIFTS: 16

Parenchymatous Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Parenchymatous Neurosyphilis

MalaCards integrated aliases for Parenchymatous Neurosyphilis:

Name: Parenchymatous Neurosyphilis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050490

Summaries for Parenchymatous Neurosyphilis

Disease Ontology : 12 A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has symptom irritability, has symptom difficulty concentrating, has symptom deterioration of memory, has symptom defective judgment, has symptom headaches, has symptom insomnia, has symptom fatigue, and has symptom lethargy.

MalaCards based summary : Parenchymatous Neurosyphilis is related to asymptomatic neurosyphilis and neurosyphilis, and has symptoms including fatigue, irritability and insomnia. An important gene associated with Parenchymatous Neurosyphilis is TCHH (Trichohyalin). Related phenotype is Negative genetic interaction between MUS81-/- and MUS81+/+.

Related Diseases for Parenchymatous Neurosyphilis

Diseases related to Parenchymatous Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 10.4
2 neurosyphilis 10.4
3 alzheimer disease 10.0
4 meningoencephalitis 10.0
5 syphilis 10.0
6 syphilitic meningitis 9.8 TCHH CD59
7 chronic inflammatory demyelinating polyradiculoneuropathy 9.6 MBP CD59
8 neuromyelitis optica 9.6 MBP CD59
9 polyneuropathy 9.5 MBP CD59
10 meningovascular neurosyphilis 9.4 TCHH MBP CD59

Graphical network of the top 20 diseases related to Parenchymatous Neurosyphilis:



Diseases related to Parenchymatous Neurosyphilis

Symptoms & Phenotypes for Parenchymatous Neurosyphilis

Symptoms:

12
  • fatigue
  • irritability
  • insomnia
  • lethargy
  • difficulty concentrating
  • deterioration of memory
  • defective judgment
  • headaches

GenomeRNAi Phenotypes related to Parenchymatous Neurosyphilis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between MUS81-/- and MUS81+/+ GR00255-A-2 8.62 CD59 MBP

Drugs & Therapeutics for Parenchymatous Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Parenchymatous Neurosyphilis

Genetic Tests for Parenchymatous Neurosyphilis

Anatomical Context for Parenchymatous Neurosyphilis

Publications for Parenchymatous Neurosyphilis

Articles related to Parenchymatous Neurosyphilis:

(show all 11)
# Title Authors PMID Year
1
Neurocognitive disorder due to neurosyphilis: a case report. 61
32888665 2020
2
[Neurosyphilis and Dementia]. 61
27056849 2016
3
Late-stage parenchymatous neurosyphilis presenting as general paresis of insane, Poland – case report 61
28230337 2016
4
A fatal fall associated with undiagnosed parenchymatous neurosyphilis. 61
24317097 2014
5
Diffuse cerebral white matter T2-weighted hyperintensity: a new finding of general paresis. 61
16875341 2006
6
Parenchymatous neurosyphilis. 61
11731886 2001
7
MRI in patients with general paresis. 61
8692419 1996
8
Electroconvulsive treatment of depression associated with neurosyphilis. 61
7174626 1982
9
[Myelin basic protein in cerebrospinal fluid in neurosyphilis (author's transl)]. 61
6159144 1980
10
[Problem of parenchymatous neurosyphilis in North Africa]. 61
13609842 1958
11
Permeability of the blood-brain barrier to penicillin in cases of parenchymatous neurosyphilis. 61
14824880 1951

Variations for Parenchymatous Neurosyphilis

Expression for Parenchymatous Neurosyphilis

Search GEO for disease gene expression data for Parenchymatous Neurosyphilis.

Pathways for Parenchymatous Neurosyphilis

GO Terms for Parenchymatous Neurosyphilis

Cellular components related to Parenchymatous Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.62 MBP CD59

Sources for Parenchymatous Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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