PNAC
MCID: PRN071
MIFTS: 23

Parenteral Nutrition-Associated Cholestasis (PNAC)

Categories: Liver diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Parenteral Nutrition-Associated Cholestasis

MalaCards integrated aliases for Parenteral Nutrition-Associated Cholestasis:

Name: Parenteral Nutrition-Associated Cholestasis 58
Pnac 58

Classifications:

Orphanet: 58  
Rare hepatic diseases


External Ids:

Orphanet 58 ORPHA567983

Summaries for Parenteral Nutrition-Associated Cholestasis

MalaCards based summary : Parenteral Nutrition-Associated Cholestasis, also known as pnac, is related to cholelithiasis and cholestasis. An important gene associated with Parenteral Nutrition-Associated Cholestasis is GPT (Glutamic--Pyruvic Transaminase). The drugs Ursodeoxycholic acid and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include liver and t cells.

Related Diseases for Parenteral Nutrition-Associated Cholestasis

Diseases related to Parenteral Nutrition-Associated Cholestasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 cholelithiasis 29.8 GPT CCK ABCB4
2 cholestasis 29.8 SLC17A5 GPT GGT1 CCK ALPP ABCB4
3 bilirubin metabolic disorder 29.7 SLC17A5 GPT GGT1 ABCB4
4 liver disease 29.4 SLC17A5 GPT GGT1 ALPP ABCB4
5 enterocolitis 10.6
6 perinatal necrotizing enterocolitis 10.6
7 short bowel syndrome 10.5
8 syphilis 10.4
9 bronchopulmonary dysplasia 10.4
10 rubella 10.3
11 toxoplasmosis 10.3
12 exudative vitreoretinopathy 1 10.2
13 volvulus of midgut 10.2
14 non-alcoholic fatty liver disease 10.2
15 suppurative cholangitis 10.1 GPT ABCB4
16 bile duct cysts 10.1 GPT ABCB4
17 paraquat poisoning 10.1 SLC17A5 GPT
18 caroli disease 10.1 GPT ABCB4
19 primary hepatic neuroendocrine carcinoma 10.1 GPT ALPP
20 hypertriglyceridemia, familial 10.1
21 gastroschisis 10.1
22 patent ductus arteriosus 1 10.1
23 rickets 10.1
24 intestinal perforation 10.1
25 intestinal disease 10.1
26 ileus 10.1
27 chickenpox 10.1
28 congenital syphilis 10.1
29 hypoglycemia 10.1
30 periodontal ehlers-danlos syndrome 10.1
31 abdominal wall defect 10.1
32 pyridoxine deficiency anemia 10.1 SLC17A5 GPT
33 methotrexate toxicity 10.1 SLC17A5 GPT
34 kwashiorkor 10.1 SLC17A5 GPT
35 rocky mountain spotted fever 10.1 SLC17A5 GPT
36 hepatic vascular disease 10.1 GPT ABCB4
37 analbuminemia 10.0 SLC17A5 GPT
38 compartment syndrome 10.0 SLC17A5 GPT
39 acute liver failure 10.0 SLC17A5 GPT
40 scrub typhus 10.0 SLC17A5 GPT
41 biliary dyskinesia 10.0 GPT CCK
42 hepatic encephalopathy 10.0 SLC17A5 GPT
43 alcoholic liver cirrhosis 10.0 SLC17A5 GPT
44 hellp syndrome 10.0 SLC17A5 GPT
45 hyperthyroidism 9.9 GPT ALPP
46 covid-19 9.9
47 dental caries 9.9
48 intrahepatic cholestasis of pregnancy 9.9 GPT ABCB4
49 opisthorchiasis 9.9 GPT GGT1
50 alkaline phosphatase, plasma level of, quantitative trait locus 1 9.9 GGT1 ALPP

Graphical network of the top 20 diseases related to Parenteral Nutrition-Associated Cholestasis:



Diseases related to Parenteral Nutrition-Associated Cholestasis

Symptoms & Phenotypes for Parenteral Nutrition-Associated Cholestasis

Drugs & Therapeutics for Parenteral Nutrition-Associated Cholestasis

Drugs for Parenteral Nutrition-Associated Cholestasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
2
Tocopherol Approved, Investigational Phase 4 1406-66-2
3 Coconut Approved Phase 4
4
Sorbitol Approved Phase 4 50-70-4 5780
5
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
6 Tocotrienol Investigational Phase 4 6829-55-6
7 Liver Extracts Phase 4
8 Pharmaceutical Solutions Phase 4
9 Soybean oil, phospholipid emulsion Phase 4
10 Soy Bean Phase 4
11 Fat Emulsions, Intravenous Phase 4
12 Parenteral Nutrition Solutions Phase 4
13 Gastrointestinal Agents Phase 4
14 Cathartics Phase 4
15 Olive Phase 4
16 Tocotrienols Phase 4
17 Tocopherols Phase 4
18 Laxatives Phase 4
19
Bilirubin Phase 2, Phase 3 635-65-4 5280352
20
Cholecystokinin Approved, Investigational 9011-97-6
21
Tauroursodeoxycholic acid Experimental, Investigational 14605-22-2 12443252
22 Anti-Infective Agents
23 Antiviral Agents
24 Phytosterol
25 Omega 3 Fatty Acid

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 The Preventative and Therapeutical Effect of Ursodeoxycholic Acid(UDCA) to Parenteral Nutrition-associated Cholestasis in Short Bowel Syndrome Completed NCT01974336 Phase 4 ursodeoxycholic acid
2 Low Dose Parenteral Fat for the Prevention of Parenteral Nutrition Associated Cholestasis in Neonates With Congenital/Acquired Gastrointestinal Disorders Terminated NCT01373918 Phase 4 Intralipid;Intralipid
3 Incidence and Severity of Parenteral Nutrition Associated Cholestasis in Neonates Subjected to Major Surgery, Using Two Mixed Intravenous Lipid Emulsions Terminated NCT02633384 Phase 4
4 Effect of Lipid Intake on Direct Hyperbilirubinemia in Late Preterm and Term Infants With Gastrointestinal Surgical Problems. Completed NCT01555957 Phase 3 intravenous lipid
5 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
6 Open Label, Compassionate Use Protocol of an Intravenous Fish Oil Emulsion in Infants With Cholestasis Completed NCT01601652 Phase 1, Phase 2 Omegaven
7 Omegaven and Parenteral Nutrition Associated Cholestasis Terminated NCT00969332 Phase 2 Omegaven
8 Sincalide (Cholecystokinin Octapeptide) Versus Placebo in Neonates at High Risk for Developing Parenteral Nutrition Associated Cholestasis Completed NCT00004414 sincalide
9 Randomized Study of Tauroursodeoxycholic Acid in Prophylactic Therapy of Total Parenteral Nutrition Associated Cholestasis in Infants Completed NCT00004410 tauroursodeoxycholic acid
10 Low Dose Parenteral Fat for Prevention of Parenteral Nutrition Associated Cholestasis in Preterm Neonates Completed NCT01050660
11 Half-life of Plasma Phytosterols in Very Low Birth Weight Preterm Infants With Parenteral Nutrition-associated Cholestasis Completed NCT02947594
12 Clinical Trial of Omegaven™ Therapy for Parenteral Nutrition Associated Cholestasis No longer available NCT02148146 Omegaven
13 Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in Infants Terminated NCT01062815

Search NIH Clinical Center for Parenteral Nutrition-Associated Cholestasis

Genetic Tests for Parenteral Nutrition-Associated Cholestasis

Anatomical Context for Parenteral Nutrition-Associated Cholestasis

MalaCards organs/tissues related to Parenteral Nutrition-Associated Cholestasis:

40
Liver, T Cells

Publications for Parenteral Nutrition-Associated Cholestasis

Articles related to Parenteral Nutrition-Associated Cholestasis:

(show top 50) (show all 236)
# Title Authors PMID Year
1
Discovery of indole-3-butyric acid derivatives as potent histone deacetylase inhibitors. 61
33445997 2021
2
Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates. 61
33557154 2021
3
Growth of Head Circumference and Body Length in Preterm Infants Receiving a Multicomponent vs a Soybean-Based Lipid Emulsion: A Randomized Controlled Trial. 61
33211326 2021
4
A multidisciplinary approach to identify priority areas for the monitoring of a vulnerable family of fishes in Spanish Marine National Parks. 61
33514312 2021
5
Plasmonic nanoparticle amyloid corona for screening Aβ oligomeric aggregate-degrading drugs. 61
33504788 2021
6
Introducing the Percent, Number, Availability, and Capacity [PNAC] Spatial Approach to Identify Priority Rural Areas Requiring Targeted Health Support in Light of COVID-19: A Commentary and Application. 61
32277774 2021
7
Absence of methamphetamine-induced conditioned place preference in weaver mutant mice. 61
32812711 2020
8
Risk factors of parenteral nutrition-associated cholestasis in very-low-birthweight infants. 61
32100397 2020
9
A Phosphine Functionalized β-Diketimine Ligand for the Synthesis of Manifold Metal Complexes. 61
32285968 2020
10
A "Push-Pull" Stabilized Phosphinidene Supported by a Phosphine-Functionalized β-Diketiminato Ligand. 61
32511823 2020
11
Harnessing the perinuclear actin cap (pnAC) to influence nanocarrier trafficking and gene transfection efficiency in skeletal myoblasts using nanopillars. 61
32442782 2020
12
Gram-negative Microbiota Blooms in Premature Twins Discordant for Parenteral Nutrition-associated Cholestasis. 61
31939866 2020
13
SMOFlipid vs Intralipid 20%: Effect of Mixed-Oil vs Soybean-Oil Emulsion on Parenteral Nutrition-Associated Cholestasis in the Neonatal Population. 61
32391595 2020
14
Andrographolide promotes pancreatic duct cells differentiation into insulin-producing cells by targeting PDX-1. 61
31887289 2020
15
Use of Fish Oil Intravenous Lipid Emulsions as Monotherapy in the Pediatric Intestinal Failure Patient: Beyond the Package Insert. 61
31549454 2020
16
[Observation on the efficacy and complications of intravenous nutrition strategy in premature infants with birth weight < 1 500 g]. 61
31898572 2019
17
SMOFlipid Protects Preterm Neonates against Perinatal Nutrition-Associated Cholestasis. 61
30620942 2019
18
Two parenteral amino acid solutions and plasma levels of amino acids in the neonate: A randomized trial. 61
30879954 2019
19
Fecal Microbiomes in Premature Infants With and Without Parenteral Nutrition-Associated Cholestasis. 61
31058777 2019
20
Sepsis and bronchopulmonary dysplasia as potential risk factors for parenteral nutrition-associated cholestasis in neonates: a meta-analysis of retrospective studies. 61
31264392 2019
21
Can mixed lipid emulsion prevent parenteral nutrition associated cholestasis? 61
30455473 2019
22
Predictive value of the aspartate aminotransferase to platelet ratio index for parenteral nutrition associated cholestasis in extremely low birth weight infants. 61
31018837 2019
23
A case report of a challenging diagnosis of biliary atresia in a patient receiving total parenteral nutrition. 61
30849955 2019
24
[mRNA expression of MDR3 gene in the blood of preterm infants with parenteral nutrition-associated cholestasis]. 61
30782273 2019
25
Enteral fish oil supplementation in the resolution of parenteral nutrition associated cholestasis. 61
30373963 2019
26
Effects of cyclic parenteral nutrition on parenteral nutrition-associated cholestasis in newborns. 61
30896413 2019
27
Intravenous Lipid Emulsions in Infants: Is Balanced Better? 61
30679255 2019
28
The effectiveness of serum amyloid A for prediction of neonatal cholestasis associated with parenteral nutrition in premature infants. 61
31559718 2019
29
Utility of hepatobiliary scintigraphy in diagnosing or excluding biliary atresia in premature neonates and full-term infants with conjugated hyperbilirubinemia who received parenteral nutrition. 61
28818034 2018
30
Copper Supplementation in Premature Infants With Parenteral Nutrition-Associated Cholestasis. 61
29529337 2018
31
Fish oil-based lipid emulsion in the treatment of parenteral nutrition-associated cholestasis. 61
30139361 2018
32
Plasma Phytosterol Half-Life and Levels Are Increased in Very Low Birth Weight Preterm Infants with Parenteral Nutrition-Associated Cholestasis. 61
30187918 2018
33
Predictive Value of the Aspartate Aminotransferase to Platelet Ratio Index for Parenteral Nutrition-Associated Cholestasis in Premature Infants With Intestinal Perforation. 61
28792861 2018
34
Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis. 61
29643332 2018
35
A pioneering study: oral clarithromycin treatment for feeding intolerance in very low birth weight preterm infants. 61
28279123 2018
36
A Mixed Lipid Emulsion for Prevention of Parenteral Nutrition Associated Cholestasis in Extremely Low Birth Weight Infants: A Randomized Clinical Trial. 61
29269199 2018
37
Half-life of plasma phytosterols in very low birth weight preterm infants on routine parenteral nutrition with vegetable oil-based lipid emulsions. 61
28063717 2018
38
Parenteral nutrition-associated cholestasis and triglyceridemia in surgical term and near-term neonates: A pilot randomized controlled trial of two mixed intravenous lipid emulsions. 61
29415837 2017
39
Gemcitabine-vitamin E conjugates: Synthesis, characterization, entrapment into nanoemulsions, and in-vitro deamination and antitumor activity. 61
28627455 2017
40
Mosapride combined with probiotics on gastrointestinal function and growth in premature infants. 61
28587329 2017
41
Retrospective Dual-Center Study of Parenteral Nutrition-Associated Cholestasis in Premature Neonates: 15 Years' Experience. 61
28135431 2017
42
The structure of a fucosylated chondroitin sulfate from the sea cucumber Cucumaria frondosa. 61
28363577 2017
43
Lipopolysaccharide of Pantoea agglomerans 7969: Chemical identification, function and biological activity. 61
28363559 2017
44
Phytosterol Esterification is Markedly Decreased in Preterm Infants Receiving Routine Parenteral Nutrition. 61
27663254 2016
45
Improvement in Parenteral Nutrition-Associated Cholestasis With the Use of Omegaven in an Infant With Short Bowel Syndrome. 61
27143651 2016
46
MassARRAY, pyrosequencing, and PNA clamping for EGFR mutation detection in lung cancer tissue and cytological samples: a multicenter study. 61
27535566 2016
47
Risk factor analysis of parenteral nutrition-associated cholestasis in extremely low birth weight infants. 61
27097151 2016
48
Liquid chromatography-mass spectroscopy as a tool in the rapid diagnosis of biliary atresia: a pilot study. 61
26995515 2016
49
Molecular impact of omega 3 fatty acids on lipopolysaccharide-mediated liver damage. 61
27072665 2016
50
Parenteral Nutrition-Associated Cholestasis in Very Low Birth Weight Infants: A Single Center Experience. 61
27066450 2016

Variations for Parenteral Nutrition-Associated Cholestasis

Expression for Parenteral Nutrition-Associated Cholestasis

Search GEO for disease gene expression data for Parenteral Nutrition-Associated Cholestasis.

Pathways for Parenteral Nutrition-Associated Cholestasis

GO Terms for Parenteral Nutrition-Associated Cholestasis

Sources for Parenteral Nutrition-Associated Cholestasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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