PNAC
MCID: PRN071
MIFTS: 25

Parenteral Nutrition-Associated Cholestasis (PNAC)

Categories: Liver diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Parenteral Nutrition-Associated Cholestasis

MalaCards integrated aliases for Parenteral Nutrition-Associated Cholestasis:

Name: Parenteral Nutrition-Associated Cholestasis 58
Pnac 58

Classifications:

Orphanet: 58  
Rare hepatic diseases


External Ids:

Orphanet 58 ORPHA567983

Summaries for Parenteral Nutrition-Associated Cholestasis

MalaCards based summary : Parenteral Nutrition-Associated Cholestasis, also known as pnac, is related to infantile liver failure syndrome 1 and bilirubin metabolic disorder. An important gene associated with Parenteral Nutrition-Associated Cholestasis is GPT (Glutamic--Pyruvic Transaminase). The drugs Ursodeoxycholic acid and Coconut have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and lung.

Related Diseases for Parenteral Nutrition-Associated Cholestasis

Diseases related to Parenteral Nutrition-Associated Cholestasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 infantile liver failure syndrome 1 30.2 SLC17A5 GPT
2 bilirubin metabolic disorder 29.3 SLC17A5 GPT GGT1 ABCB4
3 liver cirrhosis 29.2 SLC17A5 GPT GGT1
4 cholestasis 29.1 SLC17A5 GPT GGT1 CCK ALPP ABCB4
5 cholelithiasis 28.8 GPT GGT1 CCK ABCB4
6 liver disease 28.6 SLC17A5 GPT GGT1 ALPP ABCB4
7 enterocolitis 10.6
8 perinatal necrotizing enterocolitis 10.5
9 short bowel syndrome 10.4
10 syphilis 10.4
11 bronchopulmonary dysplasia 10.4
12 rubella 10.3
13 toxoplasmosis 10.3
14 covid-19 10.2
15 dental caries 10.2
16 exudative vitreoretinopathy 1 10.2
17 volvulus of midgut 10.2
18 paraquat poisoning 10.1 SLC17A5 GPT
19 primary hepatic neuroendocrine carcinoma 10.1 GPT ALPP
20 pyridoxine deficiency anemia 10.1 SLC17A5 GPT
21 granulomatous hepatitis 10.1 GPT ALPP
22 methotrexate toxicity 10.1 SLC17A5 GPT
23 rocky mountain spotted fever 10.1 SLC17A5 GPT
24 kwashiorkor 10.1 SLC17A5 GPT
25 pericholangitis 10.1 ALPP ABCB4
26 analbuminemia 10.1 SLC17A5 GPT
27 hypertriglyceridemia, familial 10.1
28 gastroschisis 10.1
29 patent ductus arteriosus 1 10.1
30 rickets 10.1
31 intestinal perforation 10.1
32 intestinal disease 10.1
33 ileus 10.1
34 chickenpox 10.1
35 congenital syphilis 10.1
36 hypoglycemia 10.1
37 periodontal ehlers-danlos syndrome 10.1
38 abdominal wall defect 10.1
39 compartment syndrome 10.1 SLC17A5 GPT
40 acute liver failure 10.0 SLC17A5 GPT
41 emphysematous cholecystitis 10.0 GPT CCK
42 cholecystitis 10.0 GPT CCK
43 scrub typhus 10.0 SLC17A5 GPT
44 acalculous cholecystitis 10.0 GPT CCK
45 cholecystolithiasis 10.0 GPT CCK
46 biliary dyskinesia 10.0 GPT CCK
47 hepatic encephalopathy 10.0 SLC17A5 GPT
48 alcoholic liver cirrhosis 10.0 SLC17A5 GPT
49 intrahepatic cholestasis of pregnancy 9.9 GPT ABCB4
50 viral laryngitis 9.9 GPT GGT1

Graphical network of the top 20 diseases related to Parenteral Nutrition-Associated Cholestasis:



Diseases related to Parenteral Nutrition-Associated Cholestasis

Symptoms & Phenotypes for Parenteral Nutrition-Associated Cholestasis

Drugs & Therapeutics for Parenteral Nutrition-Associated Cholestasis

Drugs for Parenteral Nutrition-Associated Cholestasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
2 Coconut Approved Phase 4
3
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
4
Sorbitol Approved Phase 4 50-70-4 5780
5
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
6 Tocotrienol Investigational Phase 4 6829-55-6
7 Bile Acids and Salts Phase 4
8 Liver Extracts Phase 4
9 Gastrointestinal Agents Phase 4
10 Pharmaceutical Solutions Phase 4
11 Phytosterol Phase 4
12 Olive Phase 4
13 Fat Emulsions, Intravenous Phase 4
14 Soybean oil, phospholipid emulsion Phase 4
15 Parenteral Nutrition Solutions Phase 4
16 Soy Bean Phase 4
17 Laxatives Phase 4
18 Cathartics Phase 4
19 Tocotrienols Phase 4
20 Tocopherols Phase 4
21
Taurine Approved, Nutraceutical Phase 3 107-35-7 1123
22
Methionine Approved, Nutraceutical Phase 3 63-68-3 6137
23
Cysteine Approved, Nutraceutical Phase 3 52-90-4 5862
24
Bilirubin Phase 2, Phase 3 69853-43-6, 635-65-4 21252250 5280352
25 Omega 3 Fatty Acid Phase 1, Phase 2
26
Cholecystokinin Approved, Investigational 9011-97-6
27
Tauroursodeoxycholic acid Experimental, Investigational 14605-22-2 12443252
28 Antiviral Agents
29 Anti-Infective Agents

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion Unknown status NCT01786759 Phase 4 ClinOleic;Intralipid
2 The Preventative and Therapeutical Effect of Ursodeoxycholic Acid(UDCA) to Parenteral Nutrition-associated Cholestasis in Short Bowel Syndrome Completed NCT01974336 Phase 4 ursodeoxycholic acid
3 Preventing Cholestasis in Premature Infants Using SMOFLipid® Completed NCT01585935 Phase 4 SMOFLIPID;INTRALIPID
4 Low Dose Parenteral Fat for the Prevention of Parenteral Nutrition Associated Cholestasis in Neonates With Congenital/Acquired Gastrointestinal Disorders Terminated NCT01373918 Phase 4 Intralipid;Intralipid
5 A Randomized, Double-Blind, Controlled, Clinical Trial to Evaluate the Risk of Developing Essential Fatty Acid Deficiency in Pediatric Patients, Including Neonates, Receiving Either Clinolipid (Lipid Injectable Emulsion, USP) 20% or Standard-of-Care Soybean Oil-Based Lipid Emulsion Terminated NCT02476994 Phase 4 Clinolipid;Intralipid
6 Incidence and Severity of Parenteral Nutrition Associated Cholestasis in Neonates Subjected to Major Surgery, Using Two Mixed Intravenous Lipid Emulsions Terminated NCT02633384 Phase 4
7 Effect of Lipid Intake on Direct Hyperbilirubinemia in Late Preterm and Term Infants With Gastrointestinal Surgical Problems. Completed NCT01555957 Phase 3 intravenous lipid
8 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
9 Phase 3 Study of Standard Lipid Therapy Versus Intravenous Fat Emulsion Minimization for the Prevention of Parenteral Nutrition-Associated Liver Disease Completed NCT02357576 Phase 3 Intralipid 20% I.V. Fat Emulsion
10 Omegaven as Alternative Parenteral Fat Nutrition Completed NCT03662282 Phase 3 Omegaven
11 Effect of Two Amino Acid Solutions on Blood Amino Acid Levels and Frequency of Cholestasis in Neonates Terminated NCT01062724 Phase 3
12 Clinical Trial of Omegaven™ Therapy for Parenteral Nutrition Associated Cholestasis Completed NCT02148146 Phase 1, Phase 2 Omegaven
13 Open Label, Compassionate Use Protocol of an Intravenous Fish Oil Emulsion in Infants With Cholestasis Enrolling by invitation NCT01601652 Phase 1, Phase 2 Omegaven
14 Omegaven and Parenteral Nutrition Associated Cholestasis Terminated NCT00969332 Phase 2 Omegaven
15 A Randomised Double Blind Controlled Crossover Trial of Intravenous Taurine Supplementation in Parenteral Nutrition as an Effective Treatment for Reducing Hepatobiliary Complications in Chronic Intestinal Failure Unknown status NCT00135044
16 Open Protocol for the Use of an Intravenous Fat Emulsion Comprised of Fish Oils (Omegaven) in the Treatment of Parenteral Nutrition (PN) Induced Liver Injury Approved for marketing NCT02780193 Omegaven
17 Compassionate Use of Omegaven® in the Treatment of Parenteral Nutrition Associated Hepatic Injury Approved for marketing NCT01412359 Omegaven®
18 Omegaven for Compassionate Use in the Treatment of Parenteral Nutrition-Associated Liver Disease Approved for marketing NCT03072667 Omegaven
19 Cholestasis in Extreme Low Birth Weight Infants (ELBW) - Possible Influences of a Change in Nutrition Policy Completed NCT01164878
20 Half-life of Plasma Phytosterols in Very Low Birth Weight Preterm Infants With Parenteral Nutrition-associated Cholestasis Completed NCT02947594
21 DECREASE OF CHOLESTASIS USING CYCLED PARENTERAL NUTRITION IN NEWBORNS REQUIRING PROLONGED PARENTERAL NUTRITION Completed NCT02692326
22 Half-life of Plasma Phytosterols in Very Low-birth-weight Preterm Infants on Routine Parenteral Nutrition With Soy-bean Oil Based Lipid Emulsions Completed NCT02758834
23 Low Dose Parenteral Fat for Prevention of Parenteral Nutrition Associated Cholestasis in Preterm Neonates Completed NCT01050660
24 Sincalide (Cholecystokinin Octapeptide) Versus Placebo in Neonates at High Risk for Developing Parenteral Nutrition Associated Cholestasis Completed NCT00004414 sincalide
25 Randomized Study of Tauroursodeoxycholic Acid in Prophylactic Therapy of Total Parenteral Nutrition Associated Cholestasis in Infants Completed NCT00004410 tauroursodeoxycholic acid
26 How Illness and Nutritional Support Influence Amino Acid and Acylcarnitine Profiles in Premature Neonates Completed NCT00865150
27 A Genome-Wide Association Study on Chinese Preterm Neonates and Identification of Functional Variants for Susceptibility to Necrotising Enterocolitis Recruiting NCT04074824
28 Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in Infants Terminated NCT01062815

Search NIH Clinical Center for Parenteral Nutrition-Associated Cholestasis

Genetic Tests for Parenteral Nutrition-Associated Cholestasis

Anatomical Context for Parenteral Nutrition-Associated Cholestasis

MalaCards organs/tissues related to Parenteral Nutrition-Associated Cholestasis:

40
Liver, T Cells, Lung, Testes

Publications for Parenteral Nutrition-Associated Cholestasis

Articles related to Parenteral Nutrition-Associated Cholestasis:

(show top 50) (show all 231)
# Title Authors PMID Year
1
A "push-pull" stabilized phosphinidene stabilized by a β-diketiminato ligand. 61
32511823 2020
2
Harnessing the perinuclear actin cap (pnAC) to influence nanocarrier trafficking and gene transfection efficiency in skeletal myoblasts using nanopillars. 61
32442782 2020
3
SMOFlipid vs Intralipid 20%: Effect of Mixed-Oil vs Soybean-Oil Emulsion on Parenteral Nutrition-Associated Cholestasis in the Neonatal Population. 61
32391595 2020
4
Gram-negative Microbiota Blooms in Premature Twins Discordant for Parenteral Nutrition-associated Cholestasis. 61
31939866 2020
5
Introducing the Percent, Number, Availability, and Capacity [PNAC] Spatial Approach to Identify Priority Rural Areas Requiring Targeted Health Support in Light of COVID-19: A Commentary and Application. 61
32277774 2020
6
Phosphine functionalized ß-diketimine ligand for the synthesis of manifold metal complexes. 61
32285968 2020
7
Andrographolide promotes pancreatic duct cells differentiation into insulin-producing cells by targeting PDX-1. 61
31887289 2020
8
Use of Fish Oil Intravenous Lipid Emulsions as Monotherapy in the Pediatric Intestinal Failure Patient: Beyond the Package Insert. 61
31549454 2020
9
Risk factors of parenteral nutrition-associated cholestasis in very-low-birthweight infants. 61
32100397 2020
10
SMOFlipid Protects Preterm Neonates against Perinatal Nutrition-Associated Cholestasis. 61
30620942 2019
11
[Observation on the efficacy and complications of intravenous nutrition strategy in premature infants with birth weight < 1 500 g]. 61
31898572 2019
12
Two parenteral amino acid solutions and plasma levels of amino acids in the neonate: A randomized trial. 61
30879954 2019
13
Fecal Microbiomes in Premature Infants With and Without Parenteral Nutrition-Associated Cholestasis. 61
31058777 2019
14
Sepsis and bronchopulmonary dysplasia as potential risk factors for parenteral nutrition-associated cholestasis in neonates: a meta-analysis of retrospective studies. 61
31264392 2019
15
Predictive value of the aspartate aminotransferase to platelet ratio index for parenteral nutrition associated cholestasis in extremely low birth weight infants. 61
31018837 2019
16
Can mixed lipid emulsion prevent parenteral nutrition associated cholestasis? 61
30455473 2019
17
A case report of a challenging diagnosis of biliary atresia in a patient receiving total parenteral nutrition. 61
30849955 2019
18
[mRNA expression of MDR3 gene in the blood of preterm infants with parenteral nutrition-associated cholestasis]. 61
30782273 2019
19
Effects of cyclic parenteral nutrition on parenteral nutrition-associated cholestasis in newborns. 61
30896413 2019
20
Enteral fish oil supplementation in the resolution of parenteral nutrition associated cholestasis. 61
30373963 2019
21
Intravenous Lipid Emulsions in Infants: Is Balanced Better? 61
30679255 2019
22
The effectiveness of serum amyloid A for prediction of neonatal cholestasis associated with parenteral nutrition in premature infants. 61
31559718 2019
23
Utility of hepatobiliary scintigraphy in diagnosing or excluding biliary atresia in premature neonates and full-term infants with conjugated hyperbilirubinemia who received parenteral nutrition. 61
28818034 2018
24
Copper Supplementation in Premature Infants With Parenteral Nutrition-Associated Cholestasis. 61
29529337 2018
25
Fish oil-based lipid emulsion in the treatment of parenteral nutrition-associated cholestasis. 61
30139361 2018
26
Plasma Phytosterol Half-Life and Levels Are Increased in Very Low Birth Weight Preterm Infants with Parenteral Nutrition-Associated Cholestasis. 61
30187918 2018
27
Predictive Value of the Aspartate Aminotransferase to Platelet Ratio Index for Parenteral Nutrition-Associated Cholestasis in Premature Infants With Intestinal Perforation. 61
28792861 2018
28
Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis. 61
29643332 2018
29
A pioneering study: oral clarithromycin treatment for feeding intolerance in very low birth weight preterm infants. 61
28279123 2018
30
A Mixed Lipid Emulsion for Prevention of Parenteral Nutrition Associated Cholestasis in Extremely Low Birth Weight Infants: A Randomized Clinical Trial. 61
29269199 2018
31
Half-life of plasma phytosterols in very low birth weight preterm infants on routine parenteral nutrition with vegetable oil-based lipid emulsions. 61
28063717 2018
32
Parenteral nutrition-associated cholestasis and triglyceridemia in surgical term and near-term neonates: A pilot randomized controlled trial of two mixed intravenous lipid emulsions. 61
29415837 2017
33
Gemcitabine-vitamin E conjugates: Synthesis, characterization, entrapment into nanoemulsions, and in-vitro deamination and antitumor activity. 61
28627455 2017
34
Mosapride combined with probiotics on gastrointestinal function and growth in premature infants. 61
28587329 2017
35
Retrospective Dual-Center Study of Parenteral Nutrition-Associated Cholestasis in Premature Neonates: 15 Years' Experience. 61
28135431 2017
36
The structure of a fucosylated chondroitin sulfate from the sea cucumber Cucumaria frondosa. 61
28363577 2017
37
Lipopolysaccharide of Pantoea agglomerans 7969: Chemical identification, function and biological activity. 61
28363559 2017
38
Phytosterol Esterification is Markedly Decreased in Preterm Infants Receiving Routine Parenteral Nutrition. 61
27663254 2016
39
MassARRAY, pyrosequencing, and PNA clamping for EGFR mutation detection in lung cancer tissue and cytological samples: a multicenter study. 61
27535566 2016
40
Improvement in Parenteral Nutrition-Associated Cholestasis With the Use of Omegaven in an Infant With Short Bowel Syndrome. 61
27143651 2016
41
Risk factor analysis of parenteral nutrition-associated cholestasis in extremely low birth weight infants. 61
27097151 2016
42
Liquid chromatography-mass spectroscopy as a tool in the rapid diagnosis of biliary atresia: a pilot study. 61
26995515 2016
43
Molecular impact of omega 3 fatty acids on lipopolysaccharide-mediated liver damage. 61
27072665 2016
44
Parenteral Nutrition-Associated Cholestasis in Very Low Birth Weight Infants: A Single Center Experience. 61
27066450 2016
45
Parenteral Nutrition-Associated Cholestasis in Premature Infants: Role of Macronutrients. 61
25316680 2016
46
Pediatric parenteral nutrition-associated liver disease and cholestasis: Novel advances in pathomechanisms-based prevention and treatment. 61
26698410 2016
47
Aggressive nutrition in extremely low birth weight infants: impact on parenteral nutrition associated cholestasis and growth. 61
27688976 2016
48
Soluble phosphate fertilizer production using acid effluent from metallurgical industry. 61
26496844 2016
49
Analysis of mutations of MDR3 exons 9 and 23 in infants with parenteral nutrition-associated cholestasis. 61
26668642 2015
50
Timing of ostomy reversal in neonates with necrotizing enterocolitis. 61
24792864 2015

Variations for Parenteral Nutrition-Associated Cholestasis

Expression for Parenteral Nutrition-Associated Cholestasis

Search GEO for disease gene expression data for Parenteral Nutrition-Associated Cholestasis.

Pathways for Parenteral Nutrition-Associated Cholestasis

GO Terms for Parenteral Nutrition-Associated Cholestasis

Sources for Parenteral Nutrition-Associated Cholestasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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