MCID: PRS063
MIFTS: 38

Paresthesia

Categories: Neuronal diseases, Skin diseases
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Aliases & Classifications for Paresthesia

MalaCards integrated aliases for Paresthesia:

Name: Paresthesia 52 28 5 71 75

Classifications:



External Ids:

UMLS 71 C0030554

Summaries for Paresthesia

NINDS: 52 Paresthesia refers to a burning or prickling sensation that is usually felt in the hands, arms, legs, or feet, but can also occur in other parts of the body. The sensation, which happens without warning, is usually painless and described as tingling or numbness, skin crawling, or itching. Most people have experienced temporary paresthesia -- a feeling of "pins and needles" -- at some time in their lives when they have sat with legs crossed for too long, or fallen asleep with an arm crooked under their head. It happens when sustained pressure is placed on a nerve. The feeling quickly goes away once the pressure is relieved. Chronic paresthesia is often a symptom of an underlying neurological disease or traumatic nerve damage. Paresthesia can be caused by disorders affecting the central nervous system, such as stroke and transient ischemic attacks (mini-strokes), multiple sclerosis, transverse myelitis, and encephalitis. A tumor or vascular lesion pressed up against the brain or spinal cord can also cause paresthesia. Nerve entrapment syndromes, such as carpal tunnel syndrome, can damage peripheral nerves and cause paresthesia accompanied by pain. Diagnostic evaluation is based on determining the underlying condition causing the paresthetic sensations. An individual's medical history, physical examination, and laboratory tests are essential for the diagnosis. Physicians may order additional tests depending on the suspected cause of the paresthesia.

MalaCards based summary: Paresthesia is related to carpal tunnel syndrome and pernicious anemia, and has symptoms including hyperesthesia, dysesthesia and hyperalgesia. An important gene associated with Paresthesia is CAPN3 (Calpain 3). The drugs Indian frankincense and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and dorsal root ganglion.

Wikipedia: 75 Paresthesia is an abnormal sensation of the skin (tingling, pricking, chilling, burning, numbness) with... more...

Related Diseases for Paresthesia

Diseases related to Paresthesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
# Related Disease Score Top Affiliating Genes
1 carpal tunnel syndrome 11.1
2 pernicious anemia 11.0
3 radiation-induced plexopathy 11.0
4 multiple sclerosis 10.9
5 radiculopathy 10.9
6 myelitis 10.9
7 tabes dorsalis 10.9
8 fibromyalgia 10.9
9 herpes zoster 10.9
10 keratoderma, palmoplantar, with nail dystrophy and hereditary motor-sensory neuropathy 10.9
11 pruritus, hereditary localized 10.9
12 charcot-marie-tooth disease, x-linked recessive, 3 10.9
13 charcot-marie-tooth disease, axonal, type 2i 10.9
14 paralytic poliomyelitis 10.9
15 eosinophilic meningitis 10.9
16 radial neuropathy 10.9
17 spondylosis 10.9
18 tropical spastic paraparesis 10.9
19 polyradiculopathy 10.9
20 poliomyelitis 10.9
21 facial onset sensory and motor neuronopathy 10.9
22 notalgia paresthetica 10.9
23 facial arteriovenous malformation 10.9
24 infantile mercury poisoning 10.9
25 myalgia-eosinophilia syndrome associated with tryptophan 10.9
26 polyneuropathy associated with igm monoclonal gammapathy with anti-mag 10.9
27 autoimmune hypoparathyroidism 10.9
28 full schwannomatosis 10.9
29 cone-rod dystrophy 2 10.3
30 guillain-barre syndrome, familial 10.3
31 guillain-barre syndrome 10.3
32 chronic pain 10.2
33 migraine with or without aura 1 10.1
34 pain agnosia 10.1
35 horner's syndrome 10.1
36 bell's palsy 10.1
37 facial paralysis 10.1
38 back pain 10.1
39 mononeuropathy of the median nerve, mild 10.0
40 polyneuropathy 10.0
41 neuropathy 10.0
42 pneumothorax, primary spontaneous 10.0
43 rhabdomyosarcoma 2 10.0
44 anxiety 10.0
45 major depressive disorder 10.0
46 pneumothorax 10.0
47 periapical periodontitis 10.0
48 periodontitis 10.0
49 headache 10.0
50 autoimmune disease 9.9

Graphical network of the top 20 diseases related to Paresthesia:



Diseases related to Paresthesia

Symptoms & Phenotypes for Paresthesia

UMLS symptoms related to Paresthesia:


hyperesthesia; dysesthesia; hyperalgesia; numbness; circumoral paresthesia; paresthesia, distal; paresthesia mucosal; paresthesia skin; tingling of skin; burning sensation of skin; burning mucosal; paresthesia mouth; electric shock sensation; skin sensation disturbance; tingling mucosal; back paresthesia; buttock paresthesia; extremity paresthesia; facial paresthesia; facial paresthesia, unilateral; finger paresthesia; lip paresthesia; nose paresthesia; palmar pain; palmar paresthesia; thigh numbness; thigh paresthesia; trunk paresthesia; abnormal sensation; pins and needles; paresthesia upper limb; stinging sensation; painful paresthesias; paresthesia lower limb; has tingling sensation

Drugs & Therapeutics for Paresthesia

Drugs for Paresthesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Indian frankincense Approved, Experimental, Investigational Phase 4
2
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
3
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
4
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 4 67-97-0, 1406-16-2 5280795 10883523
5
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
6
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 70-16-6 1130
7
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
8 Vitamins Phase 4
9 Vitamin B6 Phase 4
10 Calciferol Phase 4
11
Vitamin B2 Phase 4
12 Vitamin B1 Phase 4
13 Vitamin B 6 Phase 4
14 Thiamin Phase 4
15 Gotu Kola Phase 4
16 Superoxide Dismutase Phase 4
17 Analgesics Phase 4
18 Antirheumatic Agents Phase 4
19 Anti-Anxiety Agents Phase 4
20 Neurotransmitter Agents Phase 4
21 Cyclooxygenase Inhibitors Phase 4
22 Psychotropic Drugs Phase 4
23 Excitatory Amino Acid Antagonists Phase 4
24 Anti-Inflammatory Agents, Non-Steroidal Phase 4
25 Anticonvulsants Phase 4
26 Anti-Inflammatory Agents Phase 4
27 Analgesics, Non-Narcotic Phase 4
28 Anesthetics Phase 4
29 Tea Phase 4
30
Pyridoxal Experimental, Nutraceutical Phase 4 66-72-8 1050
31
Mexiletine Approved, Investigational Phase 3 5370-01-4, 31828-71-4 4178
32 Anti-Arrhythmia Agents Phase 3
33 Sodium Channel Blockers Phase 3
34 Diuretics, Potassium Sparing Phase 3
35
Imidacloprid Vet_approved Phase 2 105827-78-9 86418
36
Doxorubicin Approved, Investigational 23214-92-8 31703
37
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
38
Tetracycline Approved, Vet_approved, Withdrawn 60-54-8 5353990
39 Liposomal doxorubicin
40 Anti-Bacterial Agents
41 Anti-Infective Agents
42 Antiprotozoal Agents
43 Antiparasitic Agents
44 Antimalarials

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Effects of Bromelain and Boswellia Serrata Casperome With Centella Asiatica and Thiamine, Riboflavin, Pyridoxine, Vitamin D, Superoxide Dismutase on Edema, Paresthesia and Postoperative Pain After Quadrantectomy With or Without Sentinel Lymph Node Biopsy: Blinded Randomized Controlled Study Unknown status NCT04669119 Phase 4
2 Phase 4 Study of Efficacy of Gabapentin in the Treatment of Chest Pain and Paresthesia in Patients With Sternotomy Completed NCT00800527 Phase 4 Gabapentin;Diclofenac
3 Randomised, Prospective, Single-blind, Controlled Multicenter Study on the Safety of Two Epidural Catheters in Patients Undergoing Surgery Under Thoracic Epidural Anaesthesia Completed NCT00394459 Phase 4
4 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Mexiletine for Painful Diabetic Neuropathy Completed NCT00004647 Phase 3 mexiletine
5 A Multicentre, Randomised, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety of Acetyllevocarnitine Hydrochloride Tablets in Chinese Patients With Paresthesias Caused by Diabetic Peripheral Neuropathy Completed NCT05319275 Phase 3 Acetyllevocarnitine Hydrochloride Tablets;Placebo
6 Evaluation of Photobiomodulation Effects on Pain, Edema, Paresthesia and Bone Regeneration After Maxillar Surgical Disjunction: Double Blind, Randomized and Controlled Clinical Trial Unknown status NCT03814525 Phase 2
7 Paresthesia-free Peripheral Nerve Field Stimulation for Trigeminal Neuralgia: a Double-blinded, Randomized Trial (FreeST Trial) Recruiting NCT05615714 Phase 1, Phase 2
8 The Use of Transcutaneous Electrical Nerve Stimulation (Tens) in Reducing Symptoms of Peripheral Neuropathy Induced by Antineoplastic Chemotherapy Unknown status NCT02107417
9 The Effect of Platelet-rich Fibrin on Nerve Regeneration After Bilateral Sagittal Split Osteotomy of the Mandible Unknown status NCT03159338
10 Sensory Mapping Following Video-assisted Thoracic Surgery Unknown status NCT01375283
11 Prospective Analysis of Effect of Collagen Wrap Conduit on Radial and Ulnar Nerve Function Following Radial/Ulnar Forearm Free Flap Harvest Unknown status NCT03875833
12 CompaRison of Paresthesia Mapping to anatomIc Midline-based burSt Programming Strategies Completed NCT02986074
13 Midline vs Lateral Parasagittal Approach During Fluoroscopically Guided Interlaminar Lumbar Epidural Steroid Injection: the Role of Concordant Pressure Paresthesia in Determing Outcome. Completed NCT01760317
14 Epidemiological Study to Assess the Management of Palmar-plantar Erythrodysesthesia (PPE) in Patients With Metastatic Ovarian or Breast Cancer Treated With Pegylated Liposomal Doxorubicin Completed NCT00746694
15 Immunomodulatory and Clinical Effects of Doxycycline on Persistent Symptoms After Treatment of Neuroborreliosis: A Double-blind, Randomised, Crossover Study Completed NCT01205464 Doxycycline;Placebo
16 The Effect of Muscle Energy Technique on Femoral Meralgia Paraesthesia in Postpartum: A Randomized Controlled Trial Completed NCT04747119
17 Effects of Paresthesia Free Spinal Cord Stimulation on Pain Intensity, Functional Improvement, Pain Thresholds and Sensory Perceptions in Chronic Pain Patients Recruiting NCT03670147
18 Mechanisms and Outcome-Prognostication for Paresthesia-based and -Free Spinal Cord Stimulation in Patients With Persistent Neuropathic Pain: the MOPPStim Study Recruiting NCT03852381
19 Study to Demonstrate the Value of Paresthesia-Free Fast-Acting Subperception (FAST) and Other SCS Therapies Using WaveWriter™ Spinal Cord Stimulator Systems in the Treatment of Chronic Pain Recruiting NCT04618471
20 Effect of Electroacupuncture on Paresthesias and Functional Changes in Patients Submitted to Bimaxillary Orthognathic Surgery and Mentoplasty Recruiting NCT05310019
21 In-person Randomized Control Trial of the Incidence of Postoperative Hypoesthesia Among Bilateral Sagittal Split Osteotomy Patients Treated With Ultrasonic vs. Reciprocating Saw Instrumentation Enrolling by invitation NCT05205616
22 A Randomised Pilot Study to Assess differenCes in tHe Subjects' Experience of stimulAtion-Induced paRaesthesiA Between Two Different Spinal Cord sTimulation dEvices: the Axium® DoRsal Root Ganglion Stimulation System Versus the Prime Advanced Dorsal Column Stimulation System Terminated NCT02250469

Search NIH Clinical Center for Paresthesia

Genetic Tests for Paresthesia

Genetic tests related to Paresthesia:

# Genetic test Affiliating Genes
1 Paresthesia 28

Anatomical Context for Paresthesia

Organs/tissues related to Paresthesia:

MalaCards : Spinal Cord, Skin, Dorsal Root Ganglion, Brain, Lymph Node, Breast, Bone

Publications for Paresthesia

Articles related to Paresthesia:

(show top 50) (show all 6129)
# Title Authors PMID Year
1
Spinal cord stimulation in chronic pain treatment - first experiences in Bosnia and Herzegovina. 62
36435994 2023
2
Recurrent Optic Neuritis and Perineuritis Followed by an Unexpected Discovery: From the National Multiple Sclerosis Society Case Conference Proceedings. 62
36357190 2023
3
Comparing outcomes of radial forearm free flaps and anterolateral thigh free flaps in oral cavity reconstruction: A systematic review and meta-analysis. 62
36302325 2022
4
A remarkably rare case of Adventitial Cystic Disease of the Popliteal Artery in a 51-year-old Middle Eastern female - A Case Report. 62
36462233 2022
5
Coronary thrombosis after European adder bite in a patient on dual antiplatelet therapy: A case report. 62
36347271 2022
6
Exploring the Use of the Current Perception Threshold in Pharyngeal Paresthesia Patients. 62
34978622 2022
7
Endovenous laser ablation using laser systems emitting at wavelengths > 1900 nm: a systematic review. 62
35819662 2022
8
Thalamic Segmentation and Neural Activation Modeling Based on Individual Tissue Microstructure in Deep Brain Stimulation for Essential Tremor. 62
36470728 2022
9
A case of head and neck cutaneous squamous cell carcinoma highlighting aggressive perineural features. 62
36189160 2022
10
Pulse Intensity Effects of Burst and Tonic Spinal Cord Stimulation on Neural Responses to Brushing in Patients With Neuropathic Pain. 62
36464560 2022
11
Oral adverse outcomes associated with the buccal mucosa graft for urethroplasty. 62
36184409 2022
12
Preliminary Exploration of a New Clitoral Hood Classification System and Treatment Strategy. 62
35411409 2022
13
Sensory Symptoms and effects on Health-related Quality of Life of Patients Undergoing Lumbar Spine Surgery. 62
36396530 2022
14
Women benefit from endovenous ablation with fewer complications: Analysis of the Vascular Quality Initiative Varicose Vein Registry. 62
35933108 2022
15
Rate of periprocedural stroke in diagnostic cerebral angiograms comparing transradial versus transfemoral access. 62
36451543 2022
16
Posterior hamstring harvest improves aesthetic satisfaction and decreases sensory complications as compared to the classic anterior approach in anterior cruciate ligament reconstruction surgery. 62
36326935 2022
17
Technique of Wide-Awake Local Anesthesia No Tourniquet Injection for a Transradial Forearm Amputation in an Ischemic Hand. 62
36420462 2022
18
Combined Short-Pulse and Directional Deep Brain Stimulation of the Thalamic Ventral Intermediate Area for Essential Tremor. 62
36369082 2022
19
Effects of Acceptance and Commitment Therapy (ACT) and Mindfulness-Based Stress Reduction (MBSR) on symptoms and emotional competencies in individuals with multiple sclerosis. 62
35940019 2022
20
Early Postoperative Iatrogenic Neuropraxia After Lumbar Disc Herniation Surgery: Analysis of 87 Cases. 62
36460197 2022
21
Role of mini access during carotid endarterectomy: a prospective observational study. 62
36449023 2022
22
Amifampridine safety and efficacy in spinal muscular atrophy ambulatory patients: a randomized, placebo-controlled, crossover phase 2 trial. 62
35763114 2022
23
Maxillomandibular Advancement and Upper Airway Stimulation for Treatment of Obstructive Sleep Apnea: A Systematic Review. 62
36431259 2022
24
Carpal tunnel syndrome secondary to tumoral calcinosis: a case report and review of the literature. 62
36348303 2022
25
Trigeminal trophic syndrome in a pediatric patient with diffuse intrinsic pontine glioma. 62
36411544 2022
26
Combined Central and Peripheral Demyelination in a Case With Sjogren Syndrome. 62
35051965 2022
27
Spinal cord stimulation to treat meralgia paresthetica. Is it feasible? A case report. 62
35248503 2022
28
Complications of Unilateral Biportal Endoscopic Spinal Surgery for Lumbar Spinal Stenosis: A Systematic Review of the Literature and Meta-analysis of Single-arm Studies. 62
36394088 2022
29
Point-of-Care Ultrasound in the Diagnosis of Venous Thoracic Outlet Syndrome. 62
36369120 2022
30
Complications following laser wedge excision for idiopathic subglottic stenosis. 62
36166881 2022
31
Comparison of pericapsular nerve group (PENG) block and epidural analgesia following total hip arthroplasty: A retrospective analysis. 62
36376187 2022
32
Application of methylene blue combined with ropivacaine intercostal nerve block in postoperative analgesia of autologous costal cartilage augmentation rhinoplasty. 62
36414741 2022
33
Traditional risk factors and nodal yield-still relevant with high-quality risk-adapted adjuvant treatment for locally advanced head and neck cancer? 62
36350358 2022
34
Symptom-based characteristics and treatment efficacy of neuropathic pain related to spinal disorders. 62
34702669 2022
35
Role of Distraction Osteogenesis in the Management of Postankylotic Deformity. 62
35905392 2022
36
Successful treatment of notalgia paresthetica with lidocaine 5% medicated plaster: a case report. 62
36189717 2022
37
A 68-Year-Old Woman with a Remote History of Breast Cancer Presenting with Low Back Pain to a Chiropractic Clinic in Hong Kong with Imaging Findings Consistent with a Vertebral Hemangioma and Vertebral Metastatic Lesions. 62
36274219 2022
38
Severe ischemia after radial artery catheterization: A literature review of published cases. 62
36267019 2022
39
Central nervous system (CNS) inflammatory demyelinating diseases (IDDs) associated with COVID-19: A case series and review. 62
35939945 2022
40
Open Sciatic Nerve Decompression for Compartment Syndrome after Prolonged Lithotomy Position: A Case Report. 62
36295657 2022
41
[The Greek-Roman physician Galen of Pergamum and his neurological case histories]. 62
35606657 2022
42
Parathyroid Hormone Secretion and Related Syndromes. 62
36381723 2022
43
Transverse myelitis in a 26-year-old male with tuberculosis. 62
35936885 2022
44
Neuromyelitis optica spectrum disease coexisting with subacute combined degeneration: a case report. 62
36195830 2022
45
Intermittent Dorsal Root Ganglion Stimulation Is as Efficacious as Standard Continuous Dosing in Treating Chronic Pain: Results From a Randomized Controlled Feasibility Trial. 62
35088752 2022
46
Reversible Cerebral Vasoconstriction Syndrome in a Previously Healthy Child: A Case Report. 62
36380892 2022
47
Risk factors for complications and reoperation following operative management of displaced midshaft clavicle fractures. 62
35472574 2022
48
Efficacy and Ease of Use of a Newly Designed Pencil-Point Epidural Needle Compared to Conventional Tuohy Epidural Needle: A Randomized Single-Blind Pilot Study. 62
36276591 2022
49
Onychodynia: a new term of painful sensation and paresthesia of the nails. 62
35648440 2022
50
Degenerative Cervical Myelopathy: A Practical Approach to Diagnosis. 62
35043715 2022

Variations for Paresthesia

ClinVar genetic disease variations for Paresthesia:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CAPN3 NM_000070.3(CAPN3):c.1746-20C>G SNV Pathogenic
92408 rs201892814 GRCh37: 15:42695919-42695919
GRCh38: 15:42403721-42403721
2 CAPN3 NM_000070.3(CAPN3):c.550del (p.Thr184fs) DEL Pathogenic
17621 rs80338800 GRCh37: 15:42680001-42680001
GRCh38: 15:42387803-42387803
3 FKRP NM_024301.5(FKRP):c.826C>A (p.Leu276Ile) SNV Pathogenic
4221 rs28937900 GRCh37: 19:47259533-47259533
GRCh38: 19:46756276-46756276
4 MT-ND6 NC_012920.1:m.14477A>G SNV Uncertain Significance
523306 rs1556424448 GRCh37: MT:14477-14477
GRCh38: MT:14477-14477

Expression for Paresthesia

Search GEO for disease gene expression data for Paresthesia.

Pathways for Paresthesia

GO Terms for Paresthesia

Sources for Paresthesia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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