MCID: PRS063
MIFTS: 38

Paresthesia

Categories: Neuronal diseases, Skin diseases
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Aliases & Classifications for Paresthesia

MalaCards integrated aliases for Paresthesia:

Name: Paresthesia 52 28 5 71 75

Classifications:



External Ids:

UMLS 71 C0030554

Summaries for Paresthesia

NINDS: 52 Paresthesia refers to a burning or prickling sensation that is usually felt in the hands, arms, legs, or feet, but can also occur in other parts of the body. The sensation, which happens without warning, is usually painless and described as tingling or numbness, skin crawling, or itching. Most people have experienced temporary paresthesia -- a feeling of "pins and needles" -- at some time in their lives when they have sat with legs crossed for too long, or fallen asleep with an arm crooked under their head. It happens when sustained pressure is placed on a nerve. The feeling quickly goes away once the pressure is relieved. Chronic paresthesia is often a symptom of an underlying neurological disease or traumatic nerve damage. Paresthesia can be caused by disorders affecting the central nervous system, such as stroke and transient ischemic attacks (mini-strokes), multiple sclerosis, transverse myelitis, and encephalitis. A tumor or vascular lesion pressed up against the brain or spinal cord can also cause paresthesia. Nerve entrapment syndromes, such as carpal tunnel syndrome, can damage peripheral nerves and cause paresthesia accompanied by pain. Diagnostic evaluation is based on determining the underlying condition causing the paresthetic sensations. An individual's medical history, physical examination, and laboratory tests are essential for the diagnosis. Physicians may order additional tests depending on the suspected cause of the paresthesia.

MalaCards based summary: Paresthesia is related to carpal tunnel syndrome and pernicious anemia, and has symptoms including skin sensation disturbance, hyperalgesia and hyperesthesia. An important gene associated with Paresthesia is CAPN3 (Calpain 3). The drugs Gabapentin and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and dorsal root ganglion.

Wikipedia: 75 Paresthesia is an abnormal sensation of the skin (tingling, pricking, chilling, burning, numbness) with... more...

Related Diseases for Paresthesia

Diseases related to Paresthesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 265)
# Related Disease Score Top Affiliating Genes
1 carpal tunnel syndrome 11.1
2 pernicious anemia 11.0
3 radiation-induced plexopathy 11.0
4 multiple sclerosis 10.9
5 radiculopathy 10.9
6 myelitis 10.9
7 tabes dorsalis 10.9
8 fibromyalgia 10.9
9 herpes zoster 10.9
10 keratoderma, palmoplantar, with nail dystrophy and hereditary motor-sensory neuropathy 10.9
11 charcot-marie-tooth disease, x-linked recessive, 3 10.9
12 charcot-marie-tooth disease, axonal, type 2i 10.9
13 paralytic poliomyelitis 10.9
14 eosinophilic meningitis 10.9
15 spondylosis 10.9
16 neurilemmomatosis 10.9
17 tropical spastic paraparesis 10.9
18 poliomyelitis 10.9
19 facial onset sensory and motor neuronopathy 10.9
20 notalgia paresthetica 10.9
21 facial arteriovenous malformation 10.9
22 infantile mercury poisoning 10.9
23 myalgia-eosinophilia syndrome associated with tryptophan 10.9
24 polyneuropathy associated with igm monoclonal gammapathy with anti-mag 10.9
25 autoimmune hypoparathyroidism 10.9
26 cone-rod dystrophy 2 10.3
27 guillain-barre syndrome, familial 10.3
28 guillain-barre syndrome 10.3
29 polycystic liver disease 1 with or without kidney cysts 10.2
30 chronic pain 10.2
31 migraine with or without aura 1 10.1
32 pain agnosia 10.1
33 horner's syndrome 10.1
34 bell's palsy 10.1
35 facial paralysis 10.1
36 back pain 10.1
37 mononeuropathy of the median nerve, mild 10.0
38 polyneuropathy 10.0
39 neuropathy 10.0
40 headache 10.0
41 pneumothorax, primary spontaneous 10.0
42 rhabdomyosarcoma 2 10.0
43 anxiety 10.0
44 major depressive disorder 10.0
45 pneumothorax 10.0
46 periapical periodontitis 10.0
47 periodontitis 10.0
48 autoimmune disease 9.9
49 neuropathy, hereditary, with liability to pressure palsies 9.9
50 paine syndrome 9.9

Graphical network of the top 20 diseases related to Paresthesia:



Diseases related to Paresthesia

Symptoms & Phenotypes for Paresthesia

UMLS symptoms related to Paresthesia:


skin sensation disturbance; hyperalgesia; hyperesthesia; numbness; circumoral paresthesia; paresthesia, distal; paresthesia mucosal; paresthesia skin; tingling mucosal; tingling of skin; back paresthesia; buttock paresthesia; extremity paresthesia; facial paresthesia; facial paresthesia, unilateral; finger paresthesia; lip paresthesia; nose paresthesia; palmar pain; palmar paresthesia; burning sensation of skin; thigh numbness; thigh paresthesia; trunk paresthesia; dysesthesia; abnormal sensation; pins and needles; burning mucosal; paresthesia mouth; electric shock sensation; paresthesia upper limb; stinging sensation; painful paresthesias; paresthesia lower limb; has tingling sensation

Drugs & Therapeutics for Paresthesia

Drugs for Paresthesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
3
Indian frankincense Approved, Experimental, Investigational Phase 4
4
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
5
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 70-16-6 1130
6
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 4 67-97-0, 1406-16-2 5280795 10883523
7
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
8 Cyclooxygenase Inhibitors Phase 4
9 Excitatory Amino Acid Antagonists Phase 4
10 Antirheumatic Agents Phase 4
11 Anticonvulsants Phase 4
12 Psychotropic Drugs Phase 4
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4
14 Analgesics, Non-Narcotic Phase 4
15 Anti-Inflammatory Agents Phase 4
16 Analgesics Phase 4
17 Neurotransmitter Agents Phase 4
18 Anti-Anxiety Agents Phase 4
19 Anesthetics Phase 4
20 Tea Phase 4
21 Superoxide Dismutase Phase 4
22 Calciferol Phase 4
23 Vitamins Phase 4
24 Thiamin Phase 4
25 Vitamin B6 Phase 4
26
Vitamin B2 Phase 4
27 Vitamin B1 Phase 4
28 Vitamin B 6 Phase 4
29 Gotu Kola Phase 4
30
Pyridoxal Experimental, Nutraceutical Phase 4 66-72-8 1050
31
Mexiletine Approved, Investigational Phase 3 5370-01-4, 31828-71-4 4178
32 Sodium Channel Blockers Phase 3
33 Anti-Arrhythmia Agents Phase 3
34 Diuretics, Potassium Sparing Phase 3
35
Imidacloprid Vet_approved Phase 2 105827-78-9 86418
36
Tetracycline Approved, Vet_approved 60-54-8 5353990
37
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
38
Doxorubicin Approved, Investigational 23214-92-8 31703
39 Anti-Infective Agents
40 Antimalarials
41 Antiprotozoal Agents
42 Antiparasitic Agents
43 Anti-Bacterial Agents
44 Liposomal doxorubicin

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study of Efficacy of Gabapentin in the Treatment of Chest Pain and Paresthesia in Patients With Sternotomy Completed NCT00800527 Phase 4 Gabapentin;Diclofenac
2 Randomised, Prospective, Single-blind, Controlled Multicenter Study on the Safety of Two Epidural Catheters in Patients Undergoing Surgery Under Thoracic Epidural Anaesthesia Completed NCT00394459 Phase 4
3 Effects of Bromelain and Boswellia Serrata Casperome With Centella Asiatica and Thiamine, Riboflavin, Pyridoxine, Vitamin D, Superoxide Dismutase on Edema, Paresthesia and Postoperative Pain After Quadrantectomy With or Without Sentinel Lymph Node Biopsy: Blinded Randomized Controlled Study Recruiting NCT04669119 Phase 4
4 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Mexiletine for Painful Diabetic Neuropathy Completed NCT00004647 Phase 3 mexiletine
5 A Multicentre, Randomised, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety of Acetyllevocarnitine Hydrochloride Tablets in Chinese Patients With Paresthesias Caused by Diabetic Peripheral Neuropathy Completed NCT05319275 Phase 3 Acetyllevocarnitine Hydrochloride Tablets;Placebo
6 Evaluation of Photobiomodulation Effects on Pain, Edema, Paresthesia and Bone Regeneration After Maxillar Surgical Disjunction: Double Blind, Randomized and Controlled Clinical Trial Unknown status NCT03814525 Phase 2
7 The Use of Transcutaneous Electrical Nerve Stimulation (Tens) in Reducing Symptoms of Peripheral Neuropathy Induced by Antineoplastic Chemotherapy Unknown status NCT02107417
8 Sensory Mapping Following Video-assisted Thoracic Surgery Unknown status NCT01375283
9 The Effect of Platelet-rich Fibrin on Nerve Regeneration After Bilateral Sagittal Split Osteotomy of the Mandible Unknown status NCT03159338
10 CompaRison of Paresthesia Mapping to anatomIc Midline-based burSt Programming Strategies Completed NCT02986074
11 Midline vs Lateral Parasagittal Approach During Fluoroscopically Guided Interlaminar Lumbar Epidural Steroid Injection: the Role of Concordant Pressure Paresthesia in Determing Outcome. Completed NCT01760317
12 Immunomodulatory and Clinical Effects of Doxycycline on Persistent Symptoms After Treatment of Neuroborreliosis: A Double-blind, Randomised, Crossover Study Completed NCT01205464 Doxycycline;Placebo
13 Epidemiological Study to Assess the Management of Palmar-plantar Erythrodysesthesia (PPE) in Patients With Metastatic Ovarian or Breast Cancer Treated With Pegylated Liposomal Doxorubicin Completed NCT00746694
14 The Effect of Muscle Energy Technique on Femoral Meralgia Paraesthesia in Postpartum: A Randomized Controlled Trial Completed NCT04747119
15 Mechanisms and Outcome-Prognostication for Paresthesia-based and -Free Spinal Cord Stimulation in Patients With Persistent Neuropathic Pain: the MOPPStim Study Recruiting NCT03852381
16 Effects of Paresthesia Free Spinal Cord Stimulation on Pain Intensity, Functional Improvement, Pain Thresholds and Sensory Perceptions in Chronic Pain Patients Recruiting NCT03670147
17 Study to Demonstrate the Value of Paresthesia-Free Fast-Acting Subperception (FAST) and Other SCS Therapies Using WaveWriter™ Spinal Cord Stimulator Systems in the Treatment of Chronic Pain Recruiting NCT04618471
18 Effect of Electroacupuncture on Paresthesias and Functional Changes in Patients Submitted to Bimaxillary Orthognathic Surgery and Mentoplasty Recruiting NCT05310019
19 Prospective Analysis of Effect of Collagen Wrap Conduit on Radial and Ulnar Nerve Function Following Radial/Ulnar Forearm Free Flap Harvest Recruiting NCT03875833
20 In-person Randomized Control Trial of the Incidence of Postoperative Hypoesthesia Among Bilateral Sagittal Split Osteotomy Patients Treated With Ultrasonic vs. Reciprocating Saw Instrumentation Enrolling by invitation NCT05205616
21 A Randomised Pilot Study to Assess differenCes in tHe Subjects' Experience of stimulAtion-Induced paRaesthesiA Between Two Different Spinal Cord sTimulation dEvices: the Axium® DoRsal Root Ganglion Stimulation System Versus the Prime Advanced Dorsal Column Stimulation System Terminated NCT02250469

Search NIH Clinical Center for Paresthesia

Genetic Tests for Paresthesia

Genetic tests related to Paresthesia:

# Genetic test Affiliating Genes
1 Paresthesia 28

Anatomical Context for Paresthesia

Organs/tissues related to Paresthesia:

MalaCards : Spinal Cord, Skin, Dorsal Root Ganglion, Brain, Lymph Node, Breast, Bone

Publications for Paresthesia

Articles related to Paresthesia:

(show top 50) (show all 6085)
# Title Authors PMID Year
1
A case of head and neck cutaneous squamous cell carcinoma highlighting aggressive perineural features. 62
36189160 2022
2
Amifampridine safety and efficacy in spinal muscular atrophy ambulatory patients: a randomized, placebo-controlled, crossover phase 2 trial. 62
35763114 2022
3
Complications following laser wedge excision for idiopathic subglottic stenosis. 62
36166881 2022
4
Women benefit from endovenous ablation with fewer complications: Analysis of the Vascular Quality Initiative Varicose Vein Registry. 62
35933108 2022
5
Patient satisfaction after distal upper limb surgery under WALANT versus axillary block: A propensity-matched comparative cohort study. 62
35809895 2022
6
Clinical Outcomes of Ulnar Collateral Ligament Surgery in Nonthrowing Athletes. 62
36112993 2022
7
Emodin suppresses oxaliplatin-induced neuropathic pain by inhibiting COX2/NF-κB mediated spinal inflammation. 62
36184831 2022
8
A clinical decision aid for patients with suspected midfacial and mandibular fractures (the REDUCTION-I study): a prospective multicentre cohort study. 62
35430710 2022
9
Decellularized allografts as an alternative for reconstruction of large inferior alveolar nerve defects: a systematic review. 62
36243991 2022
10
Intermittent Dorsal Root Ganglion Stimulation Is as Efficacious as Standard Continuous Dosing in Treating Chronic Pain: Results From a Randomized Controlled Feasibility Trial. 62
35088752 2022
11
Onychodynia: a new term of painful sensation and paresthesia of the nails. 62
35648440 2022
12
Degenerative Cervical Myelopathy: A Practical Approach to Diagnosis. 62
35043715 2022
13
Postherpetic Trigeminal Trophic Syndrome: A Case Report. 62
36198630 2022
14
Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial. 62
36255427 2022
15
Dose dependent slurred speech and laryngopharyngeal dysesthesia due to oxaliplatin. 62
35119329 2022
16
Atraumatic acute compartment syndrome in anticoagulated patient: A case report. 62
36268364 2022
17
Neuromyelitis optica spectrum disease coexisting with subacute combined degeneration: a case report. 62
36195830 2022
18
Transverse myelitis in a 26-year-old male with tuberculosis. 62
35936885 2022
19
[The Greek-Roman physician Galen of Pergamum and his neurological case histories]. 62
35606657 2022
20
Central nervous system (CNS) inflammatory demyelinating diseases (IDDs) associated with COVID-19: A case series and review. 62
35939945 2022
21
Arsenic Toxicity From the Ingestion of Terracotta Pottery. 62
36229316 2022
22
Severe ischemia after radial artery catheterization: A literature review of published cases. 62
36267019 2022
23
Successful treatment of notalgia paresthetica with lidocaine 5% medicated plaster: a case report. 62
36189717 2022
24
Topical carbonic anhydrase inhibitors and glaucoma in 2021: where do we stand? 62
34433550 2022
25
Chronic inflammatory demyelinating polyradiculoneuropathy concomitant with nephropathy. 62
35737187 2022
26
White-Eyed Orbital Blowout Fracture With Oculocardiac Reflex Secondary to Extraocular Entrapment in a Pediatric Patient. 62
36109010 2022
27
Identification of Foramen Ovale With H-Figure Fluoroscopic Landmark Improves Treatment Outcomes in Idiopathic Trigeminal Neuralgia. 62
35426836 2022
28
Risk factors for complications and reoperation following operative management of displaced midshaft clavicle fractures. 62
35472574 2022
29
Adolescent Athletes can get Back in the Game after surgery for Thoracic Outlet Syndrome. 62
36243264 2022
30
Multiple sclerosis relapse after COVID-19 vaccination: A case report-based systematic review. 62
36029752 2022
31
Loss of Taste as an Initial Symptom of a "Facial Diplegia and Paresthesia" Variant of Guillain-Barré Syndrome. 62
35908975 2022
32
Acute nitrous oxide-induced neuropathy mimicking Guillain-Barré syndrome. 62
35611446 2022
33
Perioperative management of closed fracture subtrochanteric femur sinistra in type 2 diabetes mellitus with multiple comorbid: A case report. 62
36029658 2022
34
Safety evaluation of oral calcitonin-gene-related peptide receptor antagonists in patients with acute migraine: a systematic review and meta-analysis. 62
35729340 2022
35
The safety of acupuncture for migraine prevention during pregnancy. 62
35695988 2022
36
Eosinophilic granulomatosis with polyangiitis associated with abducens nerve palsy. 62
36182029 2022
37
A nutraceutical formulation combined with sclerofoam-assisted laser treatment ameliorates chronic venous insufficiency. 62
35435595 2022
38
The Long-Term Clinical Outcomes of Selectively Extracranial Radiofrequency Thermocoagulation for Trigeminal Neuralgia Guided by Three-Dimensionally Printed Personalized Template. 62
36054891 2022
39
Torasemide-induced Vascular Purpura in the Course of Eosinophilic Granulomatosis with Polyangiitis. 62
36254546 2022
40
Covid-19 vaccines and neurological complications: a systematic review. 62
36087300 2022
41
A Case of a Tarlov Cyst in a Pediatric Patient With Ehlers-Danlos Syndrome. 62
36249617 2022
42
Neuropathic pain due to compression of cervical medial branch by cervical Juxtafacet cyst: A case report. 62
35607892 2022
43
Concurrent Bell's Palsy and Facial Pain Improving with Multimodal Chiropractic Therapy: A Case Report and Literature Review. 62
36117309 2022
44
Severe Vitamin B12 Deficiency Presenting as Pancytopenia, Hemolytic Anemia, and Paresthesia: Could Your B12 Be Any Lower? 62
36259002 2022
45
Multiple Sclerosis in a Patient with Intermediate Uveitis and Juvenile Idiopathic Arthritis Treated with Adalimumab: A Case Report. 62
36150118 2022
46
Intraneural Nodular Fasciitis of the Femoral Nerve with A Unique CTNNB1::USP6 Gene Fusion: Apropos of a Case and Review of Literature. 62
35175167 2022
47
Clinical Outcomes Following Suturing of Sheath of Peroneal Tendons to the Calcaneal Plate as an Innovative Technique for Reduction of Peroneal Tendon Instability Accompanying Calcaneal Fracture. 62
36181273 2022
48
Visualizing Anatomic Variants of the Sciatic Nerve Using Diagnostic Ultrasound During Piriformis Muscle Injection: An Example of 4 Cases. 62
36118109 2022
49
Transient tunnel vision and altered consciousness after a single dose of ibuprofen. 62
36173005 2022
50
Adenoid Cystic Carcinoma (ACC) Infiltrating the Skull Base: A Systematic Review of Clinical Characteristics and Management Strategies. 62
36060029 2022

Variations for Paresthesia

ClinVar genetic disease variations for Paresthesia:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CAPN3 NM_000070.3(CAPN3):c.1746-20C>G SNV Pathogenic
92408 rs201892814 GRCh37: 15:42695919-42695919
GRCh38: 15:42403721-42403721
2 CAPN3 NM_000070.3(CAPN3):c.550del (p.Thr184fs) DEL Pathogenic
17621 rs80338800 GRCh37: 15:42680001-42680001
GRCh38: 15:42387803-42387803
3 FKRP NM_024301.5(FKRP):c.826C>A (p.Leu276Ile) SNV Pathogenic
4221 rs28937900 GRCh37: 19:47259533-47259533
GRCh38: 19:46756276-46756276
4 MT-ND6 NC_012920.1:m.14477A>G SNV Uncertain Significance
523306 rs1556424448 GRCh37: MT:14477-14477
GRCh38: MT:14477-14477

Expression for Paresthesia

Search GEO for disease gene expression data for Paresthesia.

Pathways for Paresthesia

GO Terms for Paresthesia

Sources for Paresthesia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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