MCID: PRK046
MIFTS: 10

Parkin Type of Early-Onset Parkinson Disease

Aliases & Classifications for Parkin Type of Early-Onset Parkinson Disease

MalaCards integrated aliases for Parkin Type of Early-Onset Parkinson Disease:

Name: Parkin Type of Early-Onset Parkinson Disease 24
Prkn Parkinson Disease 24
Park-Parkin 24

Summaries for Parkin Type of Early-Onset Parkinson Disease

MalaCards based summary : Parkin Type of Early-Onset Parkinson Disease, also known as prkn parkinson disease, is related to parkinson disease, late-onset and parkinson disease 2, autosomal recessive juvenile. An important gene associated with Parkin Type of Early-Onset Parkinson Disease is PRKN (Parkin RBR E3 Ubiquitin Protein Ligase). Affiliated tissues include brain and testes.

GeneReviews: NBK1478

Related Diseases for Parkin Type of Early-Onset Parkinson Disease

Diseases related to Parkin Type of Early-Onset Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 parkinson disease, late-onset 10.2
2 parkinson disease 2, autosomal recessive juvenile 10.2
3 early-onset parkinson's disease 10.2
4 dystonia 10.2
5 tremor 10.2

Graphical network of the top 20 diseases related to Parkin Type of Early-Onset Parkinson Disease:



Diseases related to Parkin Type of Early-Onset Parkinson Disease

Symptoms & Phenotypes for Parkin Type of Early-Onset Parkinson Disease

Drugs & Therapeutics for Parkin Type of Early-Onset Parkinson Disease

Search Clinical Trials , NIH Clinical Center for Parkin Type of Early-Onset Parkinson Disease

Genetic Tests for Parkin Type of Early-Onset Parkinson Disease

Anatomical Context for Parkin Type of Early-Onset Parkinson Disease

MalaCards organs/tissues related to Parkin Type of Early-Onset Parkinson Disease:

40
Brain, Testes

Publications for Parkin Type of Early-Onset Parkinson Disease

Articles related to Parkin Type of Early-Onset Parkinson Disease:

(show all 41)
# Title Authors PMID Year
1
The sooner, the later - Delayed diagnosis in Parkinson's disease due to Parkin mutations. 24
31255538 2019
2
PINK1-dependent mitophagy is driven by the UPS and can occur independently of LC3 conversion. 24
30375512 2019
3
Diagnostic delay in Parkinson's disease caused by PRKN mutations. 24
30692050 2019
4
Deep brain stimulation and genetic variability in Parkinson's disease: a review of the literature. 24
31508488 2019
5
Parkin and PINK1 mitigate STING-induced inflammation. 24
30135585 2018
6
Phase determination using chromosomal microarray and fluorescence in situ hybridization in a patient with early onset Parkinson disease and two deletions in PRKN. 24
29577677 2018
7
Genotype-Phenotype Relations for the Parkinson's Disease Genes Parkin, PINK1, DJ1: MDSGene Systematic Review. 24
29644727 2018
8
Parkinson's disease and pregnancy: An updated review. 24
28506531 2017
9
Nomenclature of genetic movement disorders: Recommendations of the international Parkinson and movement disorder society task force. 24
27079681 2016
10
High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry. 24
26011561 2015
11
Next-generation phenotyping using the parkin example: time to catch up with genetics. 24
23835509 2013
12
Parkin disease: a clinicopathologic entity? 24
23459986 2013
13
Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. 24
23212910 2013
14
Lack of association between cancer history and PARKIN genotype: a family based study in PARKIN/Parkinson's families. 24
22927236 2012
15
Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism. 24
23125018 2012
16
The neuropathology of genetic Parkinson's disease. 24
22451330 2012
17
Compensatory premotor activity during affective face processing in subclinical carriers of a single mutant Parkin allele. 24
22434215 2012
18
The relation between depression and parkin genotype: the CORE-PD study. 24
21856206 2011
19
Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism. 24
21682904 2011
20
Neuropsychological Profile of Parkin Mutation Carriers with and without Parkinson Disease: The CORE-PD Study. 24
21092386 2011
21
A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2. 24
20876472 2010
22
Nigrostriatal dysfunction in homozygous and heterozygous parkin gene carriers: an 18F-dopa PET progression study. 24
19845000 2009
23
Imaging the impact of genes on Parkinson's disease. 24
19409223 2009
24
Mapping preclinical compensation in Parkinson's disease: an imaging genomics approach. 24
19877238 2009
25
Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. 24
19025984 2008
26
Deciphering the role of heterozygous mutations in genes associated with parkinsonism. 24
17582365 2007
27
Parkinsonism and essential tremor in a family with pseudo-dominant inheritance of PARK2: an FP-CIT SPECT study. 24
17149727 2007
28
Parkin: a multifaceted ubiquitin ligase. 24
17052189 2006
29
Early-onset Parkinson's disease caused by a novel parkin mutation in a genetic isolate from north-eastern Brazil. 24
16328510 2006
30
Hereditary early-onset Parkinson's disease caused by mutations in PINK1. 24
15087508 2004
31
Parkin mutation associated parkinsonism and cognitive decline, comparison to early onset Parkinson's disease. 24
14714215 2004
32
Parkin mutations are frequent in patients with isolated early-onset parkinsonism. 24
12764050 2003
33
Pseudo-autosomal dominant inheritance of PARK2: two families with parkin gene mutations. 24
12614925 2003
34
Three parkin gene mutations in a sibship with autosomal recessive early onset parkinsonism. 24
11561042 2001
35
Pseudo-dominant inheritance and exon 2 triplication in a family with parkin gene mutations. 24
11552035 2001
36
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. 24
10973942 2000
37
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. 24
11078524 2000
38
Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism. 24
10939576 2000
39
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. 24
10888878 2000
40
Association between early-onset Parkinson's disease and mutations in the parkin gene. 24
10824074 2000
41
Parkin Type of Early-Onset Parkinson Disease 61
20301651 2001

Variations for Parkin Type of Early-Onset Parkinson Disease

Expression for Parkin Type of Early-Onset Parkinson Disease

Search GEO for disease gene expression data for Parkin Type of Early-Onset Parkinson Disease.

Pathways for Parkin Type of Early-Onset Parkinson Disease

GO Terms for Parkin Type of Early-Onset Parkinson Disease

Sources for Parkin Type of Early-Onset Parkinson Disease

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