Parkinson-Dementia Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Parkinson-Dementia Syndrome

MalaCards integrated aliases for Parkinson-Dementia Syndrome:

Name: Parkinson-Dementia Syndrome ⁵⁷ ⁷⁵ ²⁹ ⁴⁰

Supranuclear Palsy, Progressive, 1, Atypical ⁶ ⁷³

Supranuclear Palsy, Progressive Atypical ⁵⁷ ¹³

Progressive Supranuclear Palsy Atypical ⁷⁶ ⁵³

Progressive Supranuclear Palsy-Parkinsonism Syndrome ⁵⁹

Atypical Progressive Supranuclear Palsy Syndrome ⁵⁹

Steele-Richardson-Olszewski Syndrome Atypical ⁷⁵

Supranuclear Palsy Progressive 1 Atypical ⁷⁵

Atypical Psp Syndrome ⁵⁹

Psp-Parkinsonism ⁵⁹

Atypical Psp ⁵³

Psp-P ⁵⁹

Parde ⁷⁵

Characteristics:

Orphanet epidemiological data:

⁵⁹

progressive supranuclear palsy-parkinsonism syndrome
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly;

atypical progressive supranuclear palsy syndrome
Prevalence: 1-9/100000 (Europe);

OMIM:

⁵⁷

Inheritance:
autosomal recessive vs. dominant with low penetrance and expression

HPO:

³²

parkinson-dementia syndrome:
Onset and clinical course adult onset

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Mental diseases Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴ ³³

Diseases of the nervous system

Extrapyramidal and movement disorders

Other degenerative diseases of basal ganglia

Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]

Mental and behavioural disorders

Organic, including symptomatic, mental disorders

Dementia in other diseases classified elsewhere

Dementia in Parkinson disease

Orphanet: ⁵⁹

Rare neurological diseases

Rare eye diseases

External Ids:

OMIM ⁵⁷ 260540

Orphanet ⁵⁹ ORPHA240085 ORPHA99750

ICD10 via Orphanet ³⁴ G23.1

MESH via Orphanet ⁴⁵ C537240

UMLS via Orphanet ⁷⁴ C1850077

MedGen ⁴² C1850076 C1850077 C3151582

MeSH ⁴⁴ D013494

ICD10 ³³ F02.3

SNOMED-CT via HPO ⁶⁹ 52448006 32798002 26079004 more

UMLS ⁷³ C1850077

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Summaries for Parkinson-Dementia Syndrome

UniProtKB/Swiss-Prot : ⁷⁵ Parkinson-dementia syndrome: A syndrome characterized by parkinsonism, tremor, rigidity, dementia, ophthalmoparesis and pyramidal signs. Neurofibrillary degeneration occurs in the hippocampus, basal ganglia and brainstem nuclei.

MalaCards based summary : Parkinson-Dementia Syndrome, also known as supranuclear palsy, progressive, 1, atypical, is related to dementia and supranuclear palsy, progressive, 1. An important gene associated with Parkinson-Dementia Syndrome is MAPT (Microtubule Associated Protein Tau). The drugs Fluorides and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include eye and brain, and related phenotypes are ophthalmoparesis and dementia

Wikipedia : ⁷⁶ Progressive supranuclear palsy (PSP; or the Steele–Richardson–Olszewski syndrome, after the doctors who... more...

Description from OMIM: 260540

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Related Diseases for Parkinson-Dementia Syndrome

Diseases related to Parkinson-Dementia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	dementia	10.1
2	supranuclear palsy, progressive, 1	9.8
3	apraxia	9.8
4	classic progressive supranuclear palsy syndrome	9.8

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Symptoms & Phenotypes for Parkinson-Dementia Syndrome

Symptoms via clinical synopsis from OMIM:

⁵⁷

Neuro:
parkinsonism
tremor
rigidity
dementia
ophthalmoparesis
more

Misc:
onset in third decade

Skel:
kyphoscoliosis

Lab:
neurofibrillary degeneration of the hippocampus, basal ganglia and brainstem nuclei

Clinical features from OMIM:

260540

Human phenotypes related to Parkinson-Dementia Syndrome:

³² (show all 8)

#	Description	HPO Source Accession
1	ophthalmoparesis ³²	HP:0000597
2	dementia ³²	HP:0000726
3	parkinsonism ³²	HP:0001300
4	tremor ³²	HP:0001337
5	morphological abnormality of the pyramidal tract ³²	HP:0002062
6	rigidity ³²	HP:0002063
7	kyphoscoliosis ³²	HP:0002751
8	abnormal pyramidal signs ³²	HP:0007256

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Drugs & Therapeutics for Parkinson-Dementia Syndrome

Drugs for Parkinson-Dementia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Fluorides		Early Phase 1
2	Radiopharmaceuticals		Early Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Predictive and Diagnostic Value of Tau and Beta-amyloid Markers in the Dementia of Parkinson's Disease	Completed	NCT02243982	Early Phase 1
2	The Swedish BioFINDER 2 Study	Recruiting	NCT03174938	Not Applicable

Search NIH Clinical Center for Parkinson-Dementia Syndrome

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Genetic Tests for Parkinson-Dementia Syndrome

Genetic tests related to Parkinson-Dementia Syndrome:

#	Genetic test	Affiliating Genes
1	Parkinson-Dementia Syndrome ²⁹	MAPT

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Anatomical Context for Parkinson-Dementia Syndrome

MalaCards organs/tissues related to Parkinson-Dementia Syndrome:

⁴¹

Eye, Brain

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Publications for Parkinson-Dementia Syndrome

Articles related to Parkinson-Dementia Syndrome:

#	Title	Authors	Year
1	Changes in apraxia after deep brain stimulation of the nucleus basalis Meynert in a patient with Parkinson dementia syndrome. ( 20629167 )	Barnikol T.T....Freund H.J.	2010
2	Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation. ( 19506141 )	Freund H.J....Sturm V.	2009
3	New form of familial Parkinson-dementia syndrome and progressive supranuclear palsy. ( 6493510 )	Ambrosetto P....Bacci A.	1984
4	New form of familial Parkinson-dementia syndrome: clinical and pathologic findings. ( 6685236 )	Mata M....Young A.B.	1983

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Genes for Parkinson-Dementia Syndrome

Genes related to Parkinson-Dementia Syndrome (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MAPT	Microtubule Associated Protein Tau	Protein Coding	667.87	Molecular basis known ⁵⁷ Genetic Tests ²⁹ Pathogenic ⁶ Susceptibility factor ⁵⁹ GeneCards inferred via : Disorders (show sections)

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Variations for Parkinson-Dementia Syndrome

ClinVar genetic disease variations for Parkinson-Dementia Syndrome:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	MAPT	NM_016835.4(MAPT): c.1838_1840delATA (p.Asn613del)	deletion	Pathogenic,risk factor	rs63751392	GRCh37	Chromosome 17, 44087740: 44087742
2	MAPT	NM_016835.4(MAPT): c.1838_1840delATA (p.Asn613del)	deletion	Pathogenic,risk factor	rs63751392	GRCh38	Chromosome 17, 46010374: 46010376

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Expression for Parkinson-Dementia Syndrome

Search GEO for disease gene expression data for Parkinson-Dementia Syndrome.

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Pathways for Parkinson-Dementia Syndrome

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GO Terms for Parkinson-Dementia Syndrome

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Sources for Parkinson-Dementia Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia