PARDE
MCID: PRK087
MIFTS: 35
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Parkinson-Dementia Syndrome (PARDE)
Categories:
Eye diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases
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MalaCards integrated aliases for Parkinson-Dementia Syndrome:
Characteristics:Orphanet epidemiological data:58
progressive supranuclear palsy-parkinsonism syndrome
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly;
atypical progressive supranuclear palsy syndrome
Prevalence: 1-9/100000 (Europe); OMIM®:57 (Updated 05-Mar-2021)
Inheritance:
autosomal recessive vs. dominant with low penetrance and expression HPO:31
parkinson-dementia syndrome:
Inheritance autosomal recessive inheritance Onset and clinical course adult onset young adult onset Classifications:
MalaCards categories:
Global: Genetic diseases Rare diseases Anatomical: Mental diseases Neuronal diseases Eye diseases
ICD10:
32
33
Orphanet: 58
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UniProtKB/Swiss-Prot :
73
Parkinson-dementia syndrome: A syndrome characterized by parkinsonism, tremor, rigidity, dementia, ophthalmoparesis and pyramidal signs. Neurofibrillary degeneration occurs in the hippocampus, basal ganglia and brainstem nuclei.
MalaCards based summary : Parkinson-Dementia Syndrome, also known as supranuclear palsy, progressive atypical, is related to supranuclear palsy, progressive, 1 and dementia. An important gene associated with Parkinson-Dementia Syndrome is MAPT (Microtubule Associated Protein Tau). The drugs Riluzole and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and globus pallidus, and related phenotypes are parkinsonism and vertical supranuclear gaze palsy Wikipedia : 74 Progressive supranuclear palsy (PSP) is a late-onset degenerative disease involving the gradual... more...
More information from OMIM:
260540
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Diseases related to Parkinson-Dementia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:(show all 12)
Graphical network of the top 20 diseases related to Parkinson-Dementia Syndrome:![]() |
Human phenotypes related to Parkinson-Dementia Syndrome:58 31 (show all 44)
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Drugs for Parkinson-Dementia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show all 6)
Interventional clinical trials:
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MalaCards organs/tissues related to Parkinson-Dementia Syndrome:40
Eye,
Brain,
Globus Pallidus
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Articles related to Parkinson-Dementia Syndrome:(show all 11)
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ClinVar genetic disease variations for Parkinson-Dementia Syndrome:6
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Search
GEO
for disease gene expression data for Parkinson-Dementia Syndrome.
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