PARK10
MCID: PRK025
MIFTS: 34

Parkinson Disease 10 (PARK10)

Categories: Genetic diseases, Mental diseases, Metabolic diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Parkinson Disease 10

MalaCards integrated aliases for Parkinson Disease 10:

Name: Parkinson Disease 10 57 29 13 72
Parkinson Disease, Age at Onset of; Aaopd 57
Parkinson Disease, Age at Onset of 57
Park10 57
Aaopd 57

Classifications:



External Ids:

UMLS 72 C1847360

Summaries for Parkinson Disease 10

MalaCards based summary : Parkinson Disease 10, also known as parkinson disease, age at onset of; aaopd, is related to parkinson disease, late-onset and hereditary late-onset parkinson disease. An important gene associated with Parkinson Disease 10 is PARK10 (Parkinson Disease 10 (Susceptibility)), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Chks in Checkpoint Regulation. Affiliated tissues include brain, and related phenotypes are behavior/neurological and no phenotypic analysis

More information from OMIM: 606852 PS168600

Related Diseases for Parkinson Disease 10

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 1, Autosomal Dominant Parkinson Disease 15, Autosomal Recessive Early-Onset
Parkinson Disease 12 Parkinson Disease 2, Autosomal Recessive Juvenile
Parkinson Disease 3, Autosomal Dominant Parkinson Disease 4, Autosomal Dominant
Parkinson Disease 6, Autosomal Recessive Early-Onset Parkinson Disease 7, Autosomal Recessive Early-Onset
Parkinson Disease 10 Parkinson Disease 8, Autosomal Dominant
Parkinson Disease 11, Autosomal Dominant Parkinson Disease 13, Autosomal Dominant
Parkinson Disease 14, Autosomal Recessive Parkinson Disease 16
Parkinson Disease 5, Autosomal Dominant Parkinson Disease 17
Parkinson Disease 18, Autosomal Dominant Parkinson Disease 19a, Juvenile-Onset
Parkinson Disease 20, Early-Onset Parkinson Disease 21
Parkinson Disease 22, Autosomal Dominant Parkinson Disease 23, Autosomal Recessive Early-Onset
Juvenile-Onset Parkinson's Disease Early-Onset Parkinson's Disease
Parkinson Disease Type 9 Hereditary Late-Onset Parkinson Disease

Diseases related to Parkinson Disease 10 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 parkinson disease, late-onset 27.3 SNCA PRKN PINK1 PARK7 LRRK2
2 hereditary late-onset parkinson disease 10.0 SNCA LRRK2
3 postencephalitic parkinson disease 9.9 SNCA LRRK2
4 parkinson disease 6, autosomal recessive early-onset 9.8 PINK1 PARK7
5 rem sleep behavior disorder 9.8 SNCA LRRK2
6 parkinson disease 15, autosomal recessive early-onset 9.5 SNCA PRKN
7 muscular dystrophy, congenital, megaconial type 9.5 PRKN PINK1
8 leprosy 3 9.4 PRKN LRRK2
9 essential tremor 9.3 SNCA PRKN LRRK2
10 tremor 9.3 SNCA PRKN LRRK2
11 multiple system atrophy 1 9.2 SNCA PRKN LRRK2
12 gaucher's disease 9.2 SNCA PRKN
13 parkinson disease 3, autosomal dominant 8.9 SNCA PRKN PARK7 LRRK2
14 supranuclear palsy, progressive, 1 8.8 SNCA PRKN PARK7 LRRK2
15 dementia, lewy body 8.8 SNCA PRKN PARK7 LRRK2
16 dementia 8.8 SNCA PRKN PARK7 LRRK2
17 central nervous system disease 8.7 SNCA PRKN PINK1 LRRK2
18 early-onset parkinson's disease 8.3 SNCA PRKN PINK1 PARK7 LRRK2
19 parkinson disease 2, autosomal recessive juvenile 8.3 SNCA PRKN PINK1 PARK7 LRRK2
20 movement disease 8.3 SNCA PRKN PINK1 PARK7 LRRK2
21 nervous system disease 8.3 SNCA PRKN PINK1 PARK7 LRRK2

Graphical network of the top 20 diseases related to Parkinson Disease 10:



Diseases related to Parkinson Disease 10

Symptoms & Phenotypes for Parkinson Disease 10

Clinical features from OMIM:

606852

MGI Mouse Phenotypes related to Parkinson Disease 10:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 LRRK2 PARK7 PINK1 PRKN SNCA
2 no phenotypic analysis MP:0003012 8.92 LRRK2 PINK1 PRKN SNCA

Drugs & Therapeutics for Parkinson Disease 10

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effects of Exercise in Parkinson's Disease. Completed NCT01835652
2 Rehabilitation of Parkinsonian Gait in Body Weight Support Combined With Treadmill: a Controlled Study Completed NCT03815409
3 Evaluation of the Benefit Provided by Sessions of Sophrology on the Intraoperative Management of Parkinsonian Patients in the Context of Deep Brain Stimulation Surgery. Recruiting NCT03273816

Search NIH Clinical Center for Parkinson Disease 10

Genetic Tests for Parkinson Disease 10

Genetic tests related to Parkinson Disease 10:

# Genetic test Affiliating Genes
1 Parkinson Disease 10 29

Anatomical Context for Parkinson Disease 10

MalaCards organs/tissues related to Parkinson Disease 10:

41
Brain

Publications for Parkinson Disease 10

Articles related to Parkinson Disease 10:

(show all 25)
# Title Authors PMID Year
1
Association mapping of the PARK10 region for Parkinson's disease susceptibility genes. 38 8
24156912 2014
2
Fine-mapping and candidate gene investigation within the PARK10 locus. 38 8
18854859 2009
3
Investigation of the PARK10 gene in Parkinson disease. 38 8
17388942 2007
4
ELAVL4, PARK10, and the Celts. 38 8
17230446 2007
5
Genomewide association, Parkinson disease, and PARK10. 38 8
16685661 2006
6
High-resolution whole-genome association study of Parkinson disease. 38 8
16252231 2005
7
Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. 38 8
15986317 2005
8
A susceptibility gene for late-onset idiopathic Parkinson's disease. 38 8
12402251 2002
9
EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson's disease. 71
23279440 2013
10
Replication of association between ELAVL4 and Parkinson disease: the GenePD study. 8
18587682 2008
11
No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening. 8
16685662 2006
12
Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease. 8
15827745 2005
13
Parkinson Disease Overview 71
20301402 2004
14
Age at onset in two common neurodegenerative diseases is genetically controlled. 8
11875758 2002
15
Assessment of risk factor variants of LRRK2, MAPT, SNCA and TCEANC2 genes in Hungarian sporadic Parkinson's disease patients. 38
31085292 2019
16
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability. 38
30957634 2019
17
No association of PARK10 polymorphism with Parkinson's disease in Han Chinese population. 38
28651751 2017
18
Is PARK10 a Locus for Familial PD? Yes or No? 38
27090980 2016
19
Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration. 38
27063549 2016
20
TCEANC2 rs10788972 and rs12046178 variants in the PARK10 region in Chinese Han patients with sporadic Parkinson's disease. 38
26432391 2015
21
Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease in large clinical cohorts. 38
26260214 2015
22
PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease. 38
25663231 2015
23
Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder. 38
17761553 2007
24
PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain. 38
17917589 2007
25
REM sleep behavior disorder and REM sleep without atonia in patients with progressive supranuclear palsy. 38
16173657 2005

Variations for Parkinson Disease 10

Expression for Parkinson Disease 10

Search GEO for disease gene expression data for Parkinson Disease 10.

Pathways for Parkinson Disease 10

GO Terms for Parkinson Disease 10

Cellular components related to Parkinson Disease 10 according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.77 SNCA PRKN PINK1 PARK7 LRRK2
2 perinuclear region of cytoplasm GO:0048471 9.73 SNCA PRKN PINK1 PARK7
3 mitochondrial inner membrane GO:0005743 9.7 SNCA PINK1 LRRK2
4 neuron projection GO:0043005 9.69 PRKN PARK7 LRRK2
5 mitochondrial matrix GO:0005759 9.65 SNCA PARK7 LRRK2
6 mitochondrial outer membrane GO:0005741 9.58 SNCA PINK1 LRRK2
7 cell body GO:0044297 9.55 PINK1 PARK7
8 synaptic vesicle membrane GO:0030672 9.54 SNCA LRRK2
9 growth cone GO:0030426 9.5 SNCA PINK1 LRRK2
10 terminal bouton GO:0043195 9.49 SNCA LRRK2
11 inclusion body GO:0016234 9.46 SNCA LRRK2
12 axon GO:0030424 9.46 SNCA PINK1 PARK7 LRRK2
13 presynapse GO:0098793 9.43 SNCA PRKN PARK7
14 Lewy body GO:0097413 8.96 PRKN PINK1
15 mitochondrial intermembrane space GO:0005758 8.8 SNCA PINK1 PARK7

Biological processes related to Parkinson Disease 10 according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.9 SNCA PINK1 PARK7
2 negative regulation of gene expression GO:0010629 9.87 PRKN PINK1 PARK7
3 protein stabilization GO:0050821 9.85 PRKN PINK1 PARK7
4 response to oxidative stress GO:0006979 9.82 PRKN PINK1 LRRK2
5 autophagy GO:0006914 9.81 PRKN PINK1 PARK7 LRRK2
6 negative regulation of neuron apoptotic process GO:0043524 9.78 SNCA PRKN PINK1 PARK7
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.77 SNCA PINK1 PARK7
8 adult locomotory behavior GO:0008344 9.73 SNCA PRKN PARK7
9 macroautophagy GO:0016236 9.72 PRKN PINK1
10 negative regulation of protein binding GO:0032091 9.72 PARK7 LRRK2
11 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 9.72 PRKN LRRK2
12 negative regulation of cell death GO:0060548 9.72 PRKN PARK7
13 excitatory postsynaptic potential GO:0060079 9.72 SNCA LRRK2
14 positive regulation of protein binding GO:0032092 9.71 PRKN LRRK2
15 regulation of autophagy GO:0010506 9.71 PRKN LRRK2
16 positive regulation of protein ubiquitination GO:0031398 9.71 PINK1 LRRK2
17 protein destabilization GO:0031648 9.71 SNCA PRKN
18 autophagy of mitochondrion GO:0000422 9.71 PRKN PINK1
19 mitochondrion organization GO:0007005 9.71 PRKN PINK1 PARK7 LRRK2
20 activation of protein kinase B activity GO:0032148 9.7 PINK1 PARK7
21 regulation of canonical Wnt signaling pathway GO:0060828 9.7 PRKN LRRK2
22 regulation of dopamine secretion GO:0014059 9.7 SNCA PRKN
23 regulation of mitochondrial membrane potential GO:0051881 9.7 PRKN PINK1 PARK7
24 negative regulation of JNK cascade GO:0046329 9.69 PRKN PINK1
25 regulation of neuron apoptotic process GO:0043523 9.69 PINK1 PARK7
26 regulation of neurotransmitter secretion GO:0046928 9.69 SNCA PRKN
27 negative regulation of reactive oxygen species metabolic process GO:2000378 9.68 PRKN PINK1
28 regulation of neuron death GO:1901214 9.68 SNCA LRRK2
29 regulation of protein ubiquitination GO:0031396 9.68 PRKN PINK1
30 regulation of mitochondrion organization GO:0010821 9.68 PRKN PINK1
31 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.67 PARK7 LRRK2
32 positive regulation of mitochondrial fission GO:0090141 9.67 PRKN PINK1
33 regulation of reactive oxygen species metabolic process GO:2000377 9.67 SNCA PRKN PINK1
34 cellular response to oxidative stress GO:0034599 9.67 SNCA PINK1 PARK7 LRRK2
35 dopamine metabolic process GO:0042417 9.66 SNCA PRKN
36 negative regulation of oxidative stress-induced neuron death GO:1903204 9.66 PINK1 PARK7
37 negative regulation of macroautophagy GO:0016242 9.65 PINK1 LRRK2
38 negative regulation of autophagosome assembly GO:1902902 9.65 PINK1 LRRK2
39 cellular response to dopamine GO:1903351 9.65 PRKN LRRK2
40 regulation of locomotion GO:0040012 9.64 SNCA LRRK2
41 cellular response to manganese ion GO:0071287 9.63 PRKN LRRK2
42 regulation of protein targeting to mitochondrion GO:1903214 9.63 PRKN PINK1
43 synaptic transmission, dopaminergic GO:0001963 9.63 SNCA PRKN PARK7
44 protein localization to mitochondrion GO:0070585 9.62 PRKN LRRK2
45 positive regulation of autophagy of mitochondrion GO:1903599 9.62 PRKN PARK7
46 negative regulation of protein phosphorylation GO:0001933 9.62 SNCA PRKN PARK7 LRRK2
47 cellular response to toxic substance GO:0097237 9.61 PRKN PINK1
48 positive regulation of histone deacetylase activity GO:1901727 9.61 PINK1 LRRK2
49 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.61 PRKN PARK7 LRRK2
50 regulation of cellular response to oxidative stress GO:1900407 9.59 PRKN PINK1

Molecular functions related to Parkinson Disease 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.62 SNCA PRKN PARK7 LRRK2
2 enzyme binding GO:0019899 9.58 SNCA PRKN PARK7
3 actin binding GO:0003779 9.54 SNCA PRKN LRRK2
4 kinase binding GO:0019900 9.48 PRKN PARK7
5 tubulin binding GO:0015631 9.46 PRKN LRRK2
6 copper ion binding GO:0005507 9.43 SNCA PARK7
7 Hsp70 protein binding GO:0030544 9.26 SNCA PRKN
8 ubiquitin-specific protease binding GO:1990381 9.16 PRKN PARK7
9 phospholipase binding GO:0043274 8.96 SNCA PRKN
10 cuprous ion binding GO:1903136 8.62 SNCA PARK7

Sources for Parkinson Disease 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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