PARK10
MCID: PRK025
MIFTS: 39

Parkinson Disease 10 (PARK10)

Categories: Genetic diseases, Mental diseases, Metabolic diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Parkinson Disease 10

MalaCards integrated aliases for Parkinson Disease 10:

Name: Parkinson Disease 10 58 30 13 74
Parkinson Disease, Age at Onset of; Aaopd 58
Parkinson Disease, Age at Onset of 58
Park10 58
Aaopd 58

Classifications:



External Ids:

OMIM 58 606852
UMLS 74 C1847360

Summaries for Parkinson Disease 10

MalaCards based summary : Parkinson Disease 10, also known as parkinson disease, age at onset of; aaopd, is related to parkinson disease, late-onset and cone-rod dystrophy and hearing loss 2. An important gene associated with Parkinson Disease 10 is PARK10 (Parkinson Disease 10 (Susceptibility)), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Chks in Checkpoint Regulation. Affiliated tissues include brain, and related phenotypes are behavior/neurological and no phenotypic analysis

Description from OMIM: 606852

Related Diseases for Parkinson Disease 10

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 1, Autosomal Dominant Parkinson Disease 15, Autosomal Recessive Early-Onset
Parkinson Disease 12 Parkinson Disease 2, Autosomal Recessive Juvenile
Parkinson Disease 3, Autosomal Dominant Parkinson Disease 4, Autosomal Dominant
Parkinson Disease 6, Autosomal Recessive Early-Onset Parkinson Disease 7, Autosomal Recessive Early-Onset
Parkinson Disease 10 Parkinson Disease 8, Autosomal Dominant
Parkinson Disease 11, Autosomal Dominant Parkinson Disease 13, Autosomal Dominant
Parkinson Disease 14, Autosomal Recessive Parkinson Disease 16
Parkinson Disease 5, Autosomal Dominant Parkinson Disease 17
Parkinson Disease 18, Autosomal Dominant Parkinson Disease 19a, Juvenile-Onset
Parkinson Disease 20, Early-Onset Parkinson Disease 21
Parkinson Disease 22, Autosomal Dominant Parkinson Disease 23, Autosomal Recessive Early-Onset
Juvenile-Onset Parkinson's Disease Early-Onset Parkinson's Disease
Lrrk2-Related Parkinson Disease Vps35-Related Parkinson Disease
Parkinson Disease Type 9 Hereditary Late-Onset Parkinson Disease

Diseases related to Parkinson Disease 10 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 parkinson disease, late-onset 28.3 LRRK2 PARK7 PINK1 PRKN SNCA
2 cone-rod dystrophy and hearing loss 2 11.1
3 muscular dystrophy, congenital, megaconial type 10.0 PINK1 PRKN
4 parkinson disease 6, autosomal recessive early-onset 9.9 PARK7 PINK1
5 leprosy 3 9.8 LRRK2 PRKN
6 hereditary late-onset parkinson disease 9.8 LRRK2 SNCA
7 postencephalitic parkinson disease 9.7 LRRK2 SNCA
8 parkinson disease 15, autosomal recessive early-onset 9.7 PRKN SNCA
9 rem sleep behavior disorder 9.7 LRRK2 SNCA
10 multiple system atrophy 1 9.5 LRRK2 PRKN SNCA
11 essential tremor 9.5 LRRK2 PRKN SNCA
12 gaucher's disease 9.5 PRKN SNCA
13 tremor 9.5 LRRK2 PRKN SNCA
14 central nervous system disease 9.3 LRRK2 PINK1 PRKN SNCA
15 parkinson disease 3, autosomal dominant 9.2 LRRK2 PARK7 PRKN SNCA
16 supranuclear palsy, progressive, 1 9.2 LRRK2 PARK7 PRKN SNCA
17 dementia, lewy body 9.2 LRRK2 PARK7 PRKN SNCA
18 dementia 9.2 LRRK2 PARK7 PRKN SNCA
19 early-onset parkinson's disease 8.9 LRRK2 PARK7 PINK1 PRKN SNCA
20 parkinson disease 2, autosomal recessive juvenile 8.9 LRRK2 PARK7 PINK1 PRKN SNCA
21 movement disease 8.9 LRRK2 PARK7 PINK1 PRKN SNCA
22 nervous system disease 8.9 LRRK2 PARK7 PINK1 PRKN SNCA

Graphical network of the top 20 diseases related to Parkinson Disease 10:



Diseases related to Parkinson Disease 10

Symptoms & Phenotypes for Parkinson Disease 10

Clinical features from OMIM:

606852

MGI Mouse Phenotypes related to Parkinson Disease 10:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 LRRK2 PARK7 PINK1 PRKN SNCA
2 no phenotypic analysis MP:0003012 8.92 LRRK2 PINK1 PRKN SNCA

Drugs & Therapeutics for Parkinson Disease 10

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effects of Exercise in Parkinson's Disease Completed NCT01835652 Not Applicable
2 Effects of Different Physical Therapies and Dance in People With Parkinson's Disease Recruiting NCT03860649 Not Applicable
3 Effects of Nordic Walking in Parkinson Disease Patients Completed NCT03355521 Not Applicable

Search NIH Clinical Center for Parkinson Disease 10

Genetic Tests for Parkinson Disease 10

Genetic tests related to Parkinson Disease 10:

# Genetic test Affiliating Genes
1 Parkinson Disease 10 30

Anatomical Context for Parkinson Disease 10

MalaCards organs/tissues related to Parkinson Disease 10:

42
Brain

Publications for Parkinson Disease 10

Articles related to Parkinson Disease 10:

(show all 14)
# Title Authors Year
1
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability. ( 30957634 )
2019
2
No association of PARK10 polymorphism with Parkinson's disease in Han Chinese population. ( 28651751 )
2017
3
Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration. ( 27063549 )
2016
4
Is PARK10 a Locus for Familial PD? Yes or No? ( 27090980 )
2016
5
PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease. ( 25663231 )
2015
6
Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease in large clinical cohorts. ( 26260214 )
2015
7
TCEANC2 rs10788972 and rs12046178 variants in the PARK10 region in Chinese Han patients with sporadic Parkinson's disease. ( 26432391 )
2015
8
Association mapping of the PARK10 region for Parkinson's disease susceptibility genes. ( 24156912 )
2014
9
Fine-mapping and candidate gene investigation within the PARK10 locus. ( 18854859 )
2009
10
Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder. ( 17761553 )
2007
11
ELAVL4, PARK10, and the Celts. ( 17230446 )
2007
12
Investigation of the PARK10 gene in Parkinson disease. ( 17388942 )
2007
13
PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain. ( 17917589 )
2007
14
Genomewide association, Parkinson disease, and PARK10. ( 16685661 )
2006

Variations for Parkinson Disease 10

Expression for Parkinson Disease 10

Search GEO for disease gene expression data for Parkinson Disease 10.

Pathways for Parkinson Disease 10

GO Terms for Parkinson Disease 10

Cellular components related to Parkinson Disease 10 according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.77 LRRK2 PARK7 PINK1 PRKN SNCA
2 perinuclear region of cytoplasm GO:0048471 9.73 PARK7 PINK1 PRKN SNCA
3 mitochondrial inner membrane GO:0005743 9.71 LRRK2 PINK1 SNCA
4 neuron projection GO:0043005 9.7 LRRK2 PARK7 PRKN
5 mitochondrial matrix GO:0005759 9.65 LRRK2 PARK7 SNCA
6 mitochondrial outer membrane GO:0005741 9.58 LRRK2 PINK1 SNCA
7 cell body GO:0044297 9.56 PARK7 PINK1
8 synaptic vesicle membrane GO:0030672 9.55 LRRK2 SNCA
9 mitochondrial respiratory chain complex I GO:0005747 9.51 PARK7 SNCA
10 growth cone GO:0030426 9.5 LRRK2 PINK1 SNCA
11 terminal bouton GO:0043195 9.49 LRRK2 SNCA
12 inclusion body GO:0016234 9.46 LRRK2 SNCA
13 axon GO:0030424 9.46 LRRK2 PARK7 PINK1 SNCA
14 presynapse GO:0098793 9.43 PARK7 PRKN SNCA
15 Lewy body GO:0097413 8.96 PINK1 PRKN
16 mitochondrial intermembrane space GO:0005758 8.8 PARK7 PINK1 SNCA

Biological processes related to Parkinson Disease 10 according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.9 PARK7 PINK1 SNCA
2 negative regulation of gene expression GO:0010629 9.87 PARK7 PINK1 PRKN
3 protein stabilization GO:0050821 9.85 PARK7 PINK1 PRKN
4 response to oxidative stress GO:0006979 9.82 LRRK2 PINK1 PRKN
5 autophagy GO:0006914 9.81 LRRK2 PARK7 PINK1 PRKN
6 negative regulation of neuron apoptotic process GO:0043524 9.78 PARK7 PINK1 PRKN SNCA
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.77 PARK7 PINK1 SNCA
8 adult locomotory behavior GO:0008344 9.73 PARK7 PRKN SNCA
9 macroautophagy GO:0016236 9.72 PINK1 PRKN
10 negative regulation of protein binding GO:0032091 9.72 LRRK2 PARK7
11 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 9.72 LRRK2 PRKN
12 excitatory postsynaptic potential GO:0060079 9.72 LRRK2 SNCA
13 negative regulation of cell death GO:0060548 9.72 PARK7 PRKN
14 positive regulation of protein binding GO:0032092 9.71 LRRK2 PRKN
15 regulation of autophagy GO:0010506 9.71 LRRK2 PRKN
16 positive regulation of protein ubiquitination GO:0031398 9.71 LRRK2 PINK1
17 protein destabilization GO:0031648 9.71 PRKN SNCA
18 autophagy of mitochondrion GO:0000422 9.71 PINK1 PRKN
19 mitochondrion organization GO:0007005 9.71 LRRK2 PARK7 PINK1 PRKN
20 activation of protein kinase B activity GO:0032148 9.7 PARK7 PINK1
21 regulation of canonical Wnt signaling pathway GO:0060828 9.7 LRRK2 PRKN
22 regulation of dopamine secretion GO:0014059 9.7 PRKN SNCA
23 regulation of mitochondrial membrane potential GO:0051881 9.7 PARK7 PINK1 PRKN
24 negative regulation of JNK cascade GO:0046329 9.69 PINK1 PRKN
25 regulation of neuron apoptotic process GO:0043523 9.69 PARK7 PINK1
26 negative regulation of reactive oxygen species metabolic process GO:2000378 9.69 PINK1 PRKN
27 regulation of neurotransmitter secretion GO:0046928 9.68 PRKN SNCA
28 regulation of neuron death GO:1901214 9.68 LRRK2 SNCA
29 regulation of mitochondrion organization GO:0010821 9.68 PINK1 PRKN
30 regulation of protein ubiquitination GO:0031396 9.68 PINK1 PRKN
31 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.67 LRRK2 PARK7
32 dopamine metabolic process GO:0042417 9.67 PRKN SNCA
33 regulation of reactive oxygen species metabolic process GO:2000377 9.67 PINK1 PRKN SNCA
34 cellular response to oxidative stress GO:0034599 9.67 LRRK2 PARK7 PINK1 SNCA
35 positive regulation of mitochondrial fission GO:0090141 9.66 PINK1 PRKN
36 cellular response to dopamine GO:1903351 9.66 LRRK2 PRKN
37 negative regulation of autophagosome assembly GO:1902902 9.65 LRRK2 PINK1
38 negative regulation of macroautophagy GO:0016242 9.65 LRRK2 PINK1
39 negative regulation of oxidative stress-induced neuron death GO:1903204 9.65 PARK7 PINK1
40 cellular response to manganese ion GO:0071287 9.64 LRRK2 PRKN
41 regulation of locomotion GO:0040012 9.63 LRRK2 SNCA
42 cellular response to toxic substance GO:0097237 9.63 PINK1 PRKN
43 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.63 LRRK2 PARK7 PRKN
44 positive regulation of autophagy of mitochondrion GO:1903599 9.62 PARK7 PRKN
45 protein localization to mitochondrion GO:0070585 9.62 LRRK2 PRKN
46 negative regulation of protein phosphorylation GO:0001933 9.62 LRRK2 PARK7 PRKN SNCA
47 regulation of protein targeting to mitochondrion GO:1903214 9.61 PINK1 PRKN
48 positive regulation of histone deacetylase activity GO:1901727 9.61 LRRK2 PINK1
49 synaptic transmission, dopaminergic GO:0001963 9.61 PARK7 PRKN SNCA
50 positive regulation of mitophagy in response to mitochondrial depolarization GO:0098779 9.59 PINK1 PRKN

Molecular functions related to Parkinson Disease 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.62 LRRK2 PARK7 PRKN SNCA
2 enzyme binding GO:0019899 9.58 PARK7 PRKN SNCA
3 actin binding GO:0003779 9.54 LRRK2 PRKN SNCA
4 kinase binding GO:0019900 9.48 PARK7 PRKN
5 copper ion binding GO:0005507 9.46 PARK7 SNCA
6 tubulin binding GO:0015631 9.43 LRRK2 PRKN
7 Hsp70 protein binding GO:0030544 9.26 PRKN SNCA
8 ubiquitin-specific protease binding GO:1990381 9.16 PARK7 PRKN
9 phospholipase binding GO:0043274 8.96 PRKN SNCA
10 cuprous ion binding GO:1903136 8.62 PARK7 SNCA

Sources for Parkinson Disease 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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