Parkinson Disease, Late-Onset (PD)

Categories: Genetic diseases, Mental diseases, Metabolic diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Parkinson Disease, Late-Onset

MalaCards integrated aliases for Parkinson Disease, Late-Onset:

Name: Parkinson Disease, Late-Onset 56 29 6 37 71
Parkinson Disease 56 12 24 52 25 73 36 29 54 6 43 39 71 32
Parkinson's Disease 12 74 52 25 53 42 15 17
Primary Parkinsonism 52 25 73
Paralysis Agitans 12 52 73
Pd 56 25 73
Parkinson Disease, Late-Onset, Susceptibility to 56 13
Late Onset Parkinson's Disease 12 15
Late Onset Parkinson Disease 12 73
Park 56 73
Parkinson Disease, Age of Onset, Modifier 56
Susceptibility to Parkinson's Disease 6
Parkinson Disease, Susceptibility to 56
Idiopathic Parkinson's Disease 15
Idiopathic Parkinson Disease 73
Lewy Body Parkinson Disease 73
Shaking Palsy 52
Parkinson's 62



insidious onset
progressive disorder
onset mid to late adulthood

autosomal dominant


parkinson disease, late-onset:
Inheritance autosomal dominant inheritance sporadic
Onset and clinical course progressive insidious onset


Summaries for Parkinson Disease, Late-Onset

NIH Rare Diseases : 52 Parkinson disease (PD) is a neurologic disease that affects the movement. The four main symptoms are tremors of the hands, arms, legs, jaw, or head, specially at rest; rigidity, or stiffness; bradykinesia, or slow movement; and postural instability or inability to find balance. The symptoms start slowly, but progress over time, impairing everyday activities such as walking, talking, or completing simple tasks. Other symptoms may include emotional problems, trouble swallowing and speaking; urinary problems or constipation; skin problems; sleep problems, low blood pressure when standing up from sitting or lying down (postural hypotension), and inexpressive face. Some people will loose their mental abilities (dementia ). Parkinson disease affects several regions of the brain, especially a region known as "substantia nigra " that helps controlling balance and movement. Most cases of PD are sporadic (with no family history ), and with onset around 60 years of age; onset before age 20 years is considered to be juvenile-onset Parkinson disease, and after age 50 years is considered late-onset Parkinson disease. However, in some families, there are several cases of Parkinson disease. Familial cases of Parkinson disease, and maybe some sporadic cases, can be caused by changes (mutations ) in several genes , such as: Mutations in the SNCA (PARK1), LRRK2 ( PARK8 ), and VPS35 (PARK17) genes are inherited in an autosomal dominant manner. Mutations in genes PARK2 , PARK7 , and PINK1 ( PARK6 ) appear to be inherited in a recessive manner. Very rare mutations in the TAF1 gene cause Parkinson disease with X-linked inheritance. Mutations in some genes, including GBA and UCHL1 ( PARK 5 ) , do not seem to cause Parkinson disease, but to increase the risk of developing the disease in some families. Autosomal recessive PD have earlier onset than autosomal dominant PD. Some studies suggest that these genes are also involved in early-onset or juvenile PD. However, inheriting a mutation does not always mean that a person will have Parkinson's disease, because there may be other genes and environmental factors determining who will develop Parkinson disease. Treatment is usually based on a medication known as levodopa. Other medication includes bromocriptine, pramipexole, ropinirole, amantadine, rasagiline and safinamide. Deep brain stimulation (DBS) a surgical procedure where electrodes are implanted into the brain may be useful for some people. Prognosis varies, and while some people become disabled, others will have only minor movement problems. Studies have shown that people with PD who have cognitive impairment, postural hypotension, and sleep problems may have a more rapid progression of the disease.

MalaCards based summary : Parkinson Disease, Late-Onset, also known as parkinson disease, is related to parkinson disease 3, autosomal dominant and postencephalitic parkinson disease, and has symptoms including seizures, myoclonus and tremor. An important gene associated with Parkinson Disease, Late-Onset is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Parkinson disease and Spinocerebellar ataxia. The drugs Acetylcholine and Zonisamide have been mentioned in the context of this disorder. Affiliated tissues include Brain, and related phenotypes are hallucinations and abnormal autonomic nervous system physiology

Disease Ontology : 12 A synucleinopathy that has material basis in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.

Genetics Home Reference : 25 Parkinson disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement. Often the first symptom of Parkinson disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect the arms, legs, feet, and face. Other characteristic symptoms of Parkinson disease include rigidity or stiffness of the limbs and torso, slow movement (bradykinesia) or an inability to move (akinesia), and impaired balance and coordination (postural instability). These symptoms worsen slowly over time. Parkinson disease can also affect emotions and thinking ability (cognition). Some affected individuals develop psychiatric conditions such as depression and visual hallucinations. People with Parkinson disease also have an increased risk of developing dementia, which is a decline in intellectual functions including judgment and memory. Generally, Parkinson disease that begins after age 50 is called late-onset disease. The condition is described as early-onset disease if signs and symptoms begin before age 50. Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson disease.

OMIM : 56 Parkinson disease was first described by James Parkinson in 1817. It is the second most common neurodegenerative disorder after Alzheimer disease (AD; 104300), affecting approximately 1% of the population over age 50 (Polymeropoulos et al., 1996). (168600)

MedlinePlus : 42 Parkinson's disease (PD) is a type of movement disorder. It happens when nerve cells in the brain don't produce enough of a brain chemical called dopamine. Sometimes it is genetic, but most cases do not seem to run in families. Exposure to chemicals in the environment might play a role. Symptoms begin gradually, often on one side of the body. Later they affect both sides. They include Trembling of hands, arms, legs, jaw and face Stiffness of the arms, legs and trunk Slowness of movement Poor balance and coordination As symptoms get worse, people with the disease may have trouble walking, talking, or doing simple tasks. They may also have problems such as depression, sleep problems, or trouble chewing, swallowing, or speaking. There is no specific test for PD, so it can be difficult to diagnose. Doctors use a medical history and a neurological examination to diagnose it. PD usually begins around age 60, but it can start earlier. It is more common in men than in women. There is no cure for PD. A variety of medicines sometimes help symptoms dramatically. Surgery and deep brain stimulation (DBS) can help severe cases. With DBS, electrodes are surgically implanted in the brain. They send electrical pulses to stimulate the parts of the brain that control movement. NIH: National Institute of Neurological Disorders and Stroke

NINDS : 53 Parkinson's disease (PD) belongs to a group of conditions called motor system disorders, which cause unintended or uncontrollable movements of the body.  The precise cause of PD is unknown, but some cases are hereditary while others are thought to occur from a combination of genetics and environmental factors that trigger the disease.  In PD, brain cells become damaged or die in the part of the brain that produces dopamine--a chemical needed to produce smooth, purposeful movement. The four primary symptoms of PD are: tremor--shaking that has a characteristic rhythmic back and forth motion rigidity--muscle stiffness or a resistance to movement, where muscles remain constantly tense and contracted bradykinesia--slowing of spontaneous and automatic movement that can make it difficult to perform simple tasks or rapidly perform routine movements postural instability--impaired balance and changes in posture that can increase the risk of falls. Other symptoms may include difficulty swallowing, chewing, or speaking; emotional changes; urinary problems or constipation; dementia or other cognitive problems; fatigue; and problems sleeping. PD usually affects people around the age of 70 years but can occur earlier.  Women are more affected by PD.  Currently there are no specific tests that diagnose sporadic PD.

KEGG : 36 Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Both environmental factors and mutations in familial PD-linked genes such as SNCA, Parkin, DJ-1, PINK1 and LRRK2 are associated with PD pathogenesis. These pathogenic mutations and environmental factors are known to cause disease due to oxidative stress, intracellular Ca2+ homeostasis impairment, mitochondrial dysfunctions and altered protein handling compromising key roles of DA neuronal function and survival. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum, which is hypothesized to impede movement by inducing hypo and hyper activity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the basal ganglia, respectively.

UniProtKB/Swiss-Prot : 73 Parkinson disease: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features.

PubMed Health : 62 About parkinson's: Parkinson's is a disease of the nervous system that mostly affects older people. It typically begins after the age of 50. The disease can be very hard to live with because it severely restricts mobility and as a result makes daily activities increasingly difficult. Parkinson's is a progressive disease, which means that in most cases it will continue to gradually get worse. Many people who develop Parkinson’s will require nursing care. There is no cure for the disease and its exact cause is not known, but there are effective treatments that can relieve the symptoms.

Wikipedia : 74 Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central... more...

GeneReviews: NBK1223

Related Diseases for Parkinson Disease, Late-Onset

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 1, Autosomal Dominant Parkinson Disease 15, Autosomal Recessive Early-Onset
Parkinson Disease 12 Parkinson Disease 2, Autosomal Recessive Juvenile
Parkinson Disease 3, Autosomal Dominant Parkinson Disease 4, Autosomal Dominant
Parkinson Disease 6, Autosomal Recessive Early-Onset Parkinson Disease 7, Autosomal Recessive Early-Onset
Parkinson Disease 10 Parkinson Disease 8, Autosomal Dominant
Parkinson Disease 11, Autosomal Dominant Parkinson Disease 13, Autosomal Dominant
Parkinson Disease 14, Autosomal Recessive Parkinson Disease 16
Parkinson Disease 5, Autosomal Dominant Parkinson Disease 17
Parkinson Disease 18, Autosomal Dominant Parkinson Disease 19a, Juvenile-Onset
Parkinson Disease 20, Early-Onset Parkinson Disease 21
Parkinson Disease 22, Autosomal Dominant Parkinson Disease 23, Autosomal Recessive Early-Onset
Juvenile-Onset Parkinson's Disease Early-Onset Parkinson's Disease
Vps35-Related Parkinson Disease Hereditary Late-Onset Parkinson Disease

Diseases related to Parkinson Disease, Late-Onset via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1601)
# Related Disease Score Top Affiliating Genes
1 parkinson disease 3, autosomal dominant 35.0 PRKN MAPT
2 postencephalitic parkinson disease 34.9 PRKN MAPT
3 dementia, lewy body 33.5 PRKN MAPT GBA
4 tremor 32.4 PRKN MAPT GBA ATXN2
5 dementia 32.1 TBP PRKN MAPT GBA ATXN2
6 amyotrophic lateral sclerosis 1 32.0 PRKN NEAT1 MAPT MALAT1 ATXN2 ADH1C
7 movement disease 32.0 PRKN MAPT GBA
8 supranuclear palsy, progressive, 1 31.9 PRKN MAPT GBA ATXN2
9 early-onset parkinson's disease 31.8 VPS13C PRKN PINK1-AS GBA
10 rem sleep behavior disorder 31.8 PRKN MAPT GBA
11 autosomal dominant cerebellar ataxia 31.7 TBP PRKN MAPT ATXN8OS ATXN2
12 essential tremor 31.7 PRKN MAPT GBA
13 restless legs syndrome 31.6 TBP PRKN MAPT ATXN2
14 osteogenic sarcoma 31.5 SNHG1 NEAT1 MALAT1 HOTAIR
15 frontotemporal dementia 31.3 VPS13C NEAT1 MAPT ATXN2
16 oral squamous cell carcinoma 31.2 NEAT1 MIR133B MALAT1 HOTAIR
17 machado-joseph disease 31.1 TBP PRKN ATXN8OS ATXN2
18 corticobasal degeneration 30.9 MAPT GBA
19 parkinson disease 1, autosomal dominant 30.8 PRKN GBA
20 parkinson disease 2, autosomal recessive juvenile 30.8 VPS13C PRKN
21 spinocerebellar ataxia 10 30.4 ATXN8OS ATXN2
22 malignant glioma 30.4 NEAT1 MALAT1 HOTAIR
23 parkes weber syndrome 12.8
24 parkinson disease 4, autosomal dominant 12.8
25 parkinson disease 15, autosomal recessive early-onset 12.7
26 parkinson disease 23, autosomal recessive early-onset 12.7
27 parkinson disease 5, autosomal dominant 12.7
28 parkinson disease 11, autosomal dominant 12.6
29 parkinson disease 7, autosomal recessive early-onset 12.6
30 parkinson disease 13, autosomal dominant 12.6
31 parkinson disease 22, autosomal dominant 12.6
32 parkinson disease 12 12.4
33 vps35-related parkinson disease 12.3
34 glaucoma-related pigment dispersion syndrome 12.1
35 prolidase deficiency 12.0
36 capillary malformation-arteriovenous malformation 1 11.8
37 pendred syndrome 11.8
38 waisman syndrome 11.7
39 klippel-trenaunay-weber syndrome 11.6
40 panic disorder 11.6
41 pendred syndrome/nonsyndromic enlarged vestibular aqueduct 11.5
42 central pain syndrome 11.5
43 paroxysmal dyskinesia 11.5
44 lyme disease 11.5
45 juvenile-onset parkinson's disease 11.5
46 multiple system atrophy 1 11.4
47 personality disorder 11.4
48 neurogenic bladder 11.4
49 alexander disease 11.4
50 dystonia 3, torsion, x-linked 11.4

Comorbidity relations with Parkinson Disease, Late-Onset via Phenotypic Disease Network (PDN): (show all 50)

Active Peptic Ulcer Disease Acute Conjunctivitis
Acute Cystitis Alzheimer Disease
Anxiety Atypical Depressive Disorder
Autonomic Nervous System Disease Bipolar Disorder
Blepharitis Bronchitis
Bronchopneumonia Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Communicating Hydrocephalus Conjunctivitis
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dysthymic Disorder
Early-Onset Generalized Limb-Onset Dystonia Encephalopathy
Erythematosquamous Dermatosis Esophagitis
Generalized Atherosclerosis Heart Disease
Hypothyroidism Iron Deficiency Anemia
Leukodystrophy Major Affective Disorder 9
Major Depressive Disorder Marasmus
Mood Disorder Neurogenic Bladder
Obstructive Hydrocephalus Osteoporosis
Paralytic Ileus Paranoid Schizophrenia
Pernicious Anemia Personality Disorder
Prostatic Hypertrophy Protein-Energy Malnutrition
Pseudobulbar Palsy Schizophrenia
Schizophreniform Disorder Swallowing Disorders
Tardive Dyskinesia Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Parkinson Disease, Late-Onset:

Diseases related to Parkinson Disease, Late-Onset

Symptoms & Phenotypes for Parkinson Disease, Late-Onset

Human phenotypes related to Parkinson Disease, Late-Onset:

31 (show all 24)
# Description HPO Frequency HPO Source Accession
1 hallucinations 31 occasional (7.5%) HP:0000738
2 abnormal autonomic nervous system physiology 31 occasional (7.5%) HP:0012332
3 sleep disturbance 31 HP:0002360
4 dysphagia 31 HP:0002015
5 tremor 31 HP:0001337
6 depressivity 31 HP:0000716
7 mask-like facies 31 HP:0000298
8 dysarthria 31 HP:0001260
9 constipation 31 HP:0002019
10 dystonia 31 HP:0001332
11 weak voice 31 HP:0001621
12 rigidity 31 HP:0002063
13 dementia 31 HP:0000726
14 personality changes 31 HP:0000751
15 postural instability 31 HP:0002172
16 urinary urgency 31 HP:0000012
17 parkinsonism 31 HP:0001300
18 neuronal loss in central nervous system 31 HP:0002529
19 bradykinesia 31 HP:0002067
20 short stepped shuffling gait 31 HP:0007311
21 resting tremor 31 HP:0002322
22 lewy bodies 31 HP:0100315
23 substantia nigra gliosis 31 HP:0011960
24 micrographia 31 HP:0031908

Symptoms via clinical synopsis from OMIM:

Abdomen Gastrointestinal:

Genitourinary Bladder:
urinary urgency

Head And Neck Face:
masked facies

Neurologic Central Nervous System:
postural instability
Neurologic Behavioral Psychiatric Manifestations:

Head And Neck Nose:
decreased sense of smell

Clinical features from OMIM:


UMLS symptoms related to Parkinson Disease, Late-Onset:

seizures, myoclonus, tremor, back pain, angina pectoris, constipation, headache, hyposmia, syncope, pain, bradykinesia, resting tremor, chronic pain, sciatica, sleep disturbances, vertigo/dizziness, equilibration disorder, sleeplessness, muscle rigidity, urgency of micturition

Drugs & Therapeutics for Parkinson Disease, Late-Onset

PubMed Health treatment related to Parkinson Disease, Late-Onset: 62

Parkinson 's is usually treated with medication. At the beginning of the disease – when the symptoms are not problematic – treatment is sometimes not necessary. If the symptoms get worse, medication can help. Treatment with medication generally aims to replace the lacking dopamine . That often relieves symptoms, but does not slow the progress of the disease. Because over time the drugs are no longer effective, the type and dose of medication has to be adjusted again and again. One option is to use a medication pump. It provides the drug either under the skin or directly into the small intestine and ensures a constant supply. Occupational therapy is used to practice everyday movements and activities. Restricted movement means that the muscles lose strength. Movement exercises (physiotherapy ) and sports aim to help counteract that and improve movement and coordination. Speech therapy can be an option if the voice becomes quieter and speech less clear. Deep brain stimulation is recommended to some people whose symptoms are not relieved enough by taking medication. That involves surgery to implant electrodes in certain parts of the brain. They continuously emit electrical impulses that influence muscle activity.

Drugs for Parkinson Disease, Late-Onset (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 628)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
Zonisamide Approved, Investigational Phase 4 68291-97-4 5734
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
Sulfanilamide Approved Phase 4 63-74-1 5333
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
Dinoprostone Approved Phase 4 363-24-6 5280360
Trimethobenzamide Approved, Investigational Phase 4 138-56-7 5577
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 497540 5095
Amantadine Approved Phase 4 768-94-5 2130
Sodium citrate Approved, Investigational Phase 4 68-04-2
Benserazide Approved, Investigational Phase 4 322-35-0
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
Mirabegron Approved Phase 4 223673-61-8 9865528
Simvastatin Approved Phase 4 79902-63-9 54454
Capsaicin Approved Phase 4 404-86-4 1548943
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Lactulose Approved Phase 4 4618-18-2 11333
Ondansetron Approved Phase 4 99614-02-5 4595
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
Primaquine Approved Phase 4 90-34-6 4908
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
Cycloserine Approved Phase 4 68-41-7 401 6234
Simethicone Approved Phase 4 8050-81-5
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
Ezetimibe Approved Phase 4 163222-33-1 150311
Mycophenolic acid Approved Phase 4 24280-93-1 446541
Basiliximab Approved, Investigational Phase 4 152923-56-3, 179045-86-4
Linaclotide Approved Phase 4 851199-59-2 65351
Ethanol Approved Phase 4 64-17-5 702
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Remifentanil Approved Phase 4 132875-61-7 60815
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
Suvorexant Approved, Investigational Phase 4 1030377-33-3
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
Benzoyl peroxide Approved Phase 4 94-36-0 7187
Donepezil Approved Phase 4 120014-06-4 3152
Topiramate Approved Phase 4 97240-79-4 5284627
Memantine Approved, Investigational Phase 4 19982-08-2 4054
Zoledronic Acid Approved Phase 4 118072-93-8 68740
Iodine Approved, Investigational Phase 4 7553-56-2 807
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0

Interventional clinical trials:

(show top 50) (show all 3438)
# Name Status NCT ID Phase Drugs
1 A Prospective Randomized Placebo-Controlled Double-Blind Study Assessing Change in Olfactory Function After Initiation of Rasagiline in Idiopathic Parkinson's Disease Unknown status NCT01007630 Phase 4 Rasagiline;Placebo
2 An Open-Label Tolerability and Exploratory Efficacy Study of Zonisamide for Dyskinesias in Parkinson's Disease Unknown status NCT03034538 Phase 4 Zonegran;Zonegran
3 Evaluation of the Efficacy of Rasagiline in Apathy in Drug-naïve Patients With Parkinson's Disease by a Multi-center, Randomized, Double-blind, Parallel-group, Placebo-controlled Study. Unknown status NCT01765257 Phase 4 AZILECT®;Placebo
4 Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease: Double Blind, Randomized, Placebo Controlled Trial Unknown status NCT02768077 Phase 4 Melatonin(Circadin®);Placebo
5 Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease: Double Blind, Randomized, Placebo Controlled Trial Unknown status NCT03258294 Phase 4 Melatonin(Circadin®);Placebo Oral Tablet
6 A Randomized, Double-Blind, Placebo-Controlled Study of Droxidopa for Fatigue in Parkinson's Disease Unknown status NCT03034564 Phase 4 Northera;Placebo Oral Tablet
7 A Randomized, Double-blind, Placebo Controlled, Crossover Study to Evaluate the Effect of Donepezil on Gait and Balance in Parkinson's Disease Unknown status NCT01521117 Phase 4 Donepezil
8 The Effects of Rasagiline on Cognitive Deficits Associated With Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study Over 3 Months Unknown status NCT00696215 Phase 4 placebo;rasagiline
9 An Open-label, Randomized, Multi-center, Crossover Study to Observe the Effect of Once-daily Mirapex ER® and Twice-daily Mirapex ER® in Patients With Parkinson Disease Unknown status NCT01515774 Phase 4 Mirapex ER
10 Mirabegron for Treatment of Overactive Bladder Symptoms in Patients With Parkinson's Disease: a Double-blind, Randomized Placebo-controlled Trial Unknown status NCT03412513 Phase 4 Mirabegron;Placebo
11 Cognitive Dysfunction in PD: Pathophysiology and Potential Treatments, a Pilot Study Unknown status NCT01340885 Phase 4 Strattera;Exelon
12 The Use of Toxin Botulinum A Toxin in Patients With Parkinson's Disease and Multiple System Disease, Affected by Refractory Detrusor Overactivity. Unknown status NCT00822913 Phase 4 Intravesical injection of Botulinum A toxin
13 An Open-label Trial of Oral Selegiline 5 or 10 mg and Tadalafil 2.5mg Co-administration to Male Patients With Parkinson's Disease and Moderate Erectile Dysfunction. Unknown status NCT02225548 Phase 4 Selegiline;Tadalafil
14 Effect of Deep Brain Stimulation on Gait of Patients With Parkinson's Disease Depending on Electrode Location in Subthalamic Area. Unknown status NCT01782638 Phase 4
15 Efficacy of Levodopa/Benserazide Dispersible Tablet on Response Fluctuations in Parkinson's Disease Patients With Delayed ON: a Multicenter Randomized Open-label Cross-over Trial Unknown status NCT02769793 Phase 4 Levodopa dispersible;Levodopa
16 Double Bind Randomized Placebo-controlled Cross-over Study to Evaluate Effect of Continuous Apomorphine During the Night on Sleep Disorders in Insomniac Patients With Parkinson's Disease Unknown status NCT02940912 Phase 4 Apomorphine;Placebo
17 Nicotine Treatment of Impulsivity in Parkinson's Disease: A Pilot Study Unknown status NCT01216904 Phase 4 nicotine patch;placebo
18 A Study of the Utility of Botulinum Toxin Type A for Pain in Advanced Parkinson's Disease Double Blind Placebo Control Crossover Pilot Study Unknown status NCT02472210 Phase 4 Botulinum Toxin
19 Wuling Powder for the Treatment and Underlying Mechanism of Depressive Symptoms in Patients With Parkinson's Disease: a Randomised, Double-blind, Placebo-controlled Trial. Unknown status NCT03195231 Phase 4 Wuling Powder;Placebo
20 Role of Dopamine on Loss Aversion Behaviour: Study on Parkinsonian Patients. Unknown status NCT01780467 Phase 4
21 Effects of Different Concentrations of Dexmedetomidine on Basal Ganglia Neuronal Activity (Local Field Potentials) in Parkinson's Disease Unknown status NCT02982512 Phase 4 Dexmedetomidine
22 Rotigotine Effect on Nocturnal Hypokinesia Compares to Placebo Control: A Quantitative Assessment by Wearable Sensors Unknown status NCT03098368 Phase 4 Rotigotine;Placebo
23 Clinical Psychopharmacology Division Institute of Mental Health, Peking University Unknown status NCT03148509 Phase 4 risperidone;aripiprazole;bupropion
24 Effect of Acetylcholinesterase Inhibitors on the Gait of the Patients With Parkinson Disease Characterized by Postural Instability and Gait Disturbance Unknown status NCT03011476 Phase 4 Donepezil;Placebos
25 Effects of Azilect (Rasagiline) on Processing of Emotions, Mood and Executive Function in Parkinson`s Disease Unknown status NCT01385735 Phase 4 Rasagiline;Placebo
26 Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Unknown status NCT01786005 Phase 4
27 A Double Blind, Placebo-controlled Study for the Effect of IV Amantadine on Freezing of Gait (FOG) Resistant to Dopaminergic Therapy Unknown status NCT01313819 Phase 4 PK-Merz® 200mg/500ml inj(Amantadine) , Normal saline 500ml inj
28 An Evaluation of Sulfadoxine-pyrimethamine Resistance and Effectiveness of IPTp in Nigeria Unknown status NCT01636895 Phase 4 Efficacy of suphladoxine/pyrimethamine as IPTp;Efficacy of suphladoxine/pyrimethamine as IPTp
29 The Study to Assess the Effect of Trimetazidine on Index of Microcirculatory Resistance (IMR), Measured by Coronary Pressure and Temperature Wire, in Patients With Stable Coronary Artery Disease Unknown status NCT02107144 Phase 4 trimetazidine
30 Therapeutic Effect of Ursodeoxycholic Acid on Duodenal Permeability and Meal Related Sensory Motor Function in Functional Dyspepsia Patients Unknown status NCT03004118 Phase 4 Placebo Oral Tablet;Ursochol oral tablet
31 A Randomized, Double-blind, Placebo-controlled Study of Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy Unknown status NCT01328652 Phase 4 dexlansoprazole
32 Treatment With Acetyl-Choline Esterase Inhibitors in Children With Autism Unknown status NCT01098383 Phase 4 Acetyl-Choline Esterase Inhibitors and Choline supplements;Indistinguishable placebo tablets, matching both donepezil and choline
33 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
34 Double Blind, Placebo-controlled, Parallel, Multicenter, Randomized Interventional Phase IV Study to Evaluate the Efficacy of Rotigotine on Depressive Symptoms in Idiopathic Parkinson's Disease Patients Completed NCT01523301 Phase 4 Rotigotine;Placebo
35 An Open-Label, Multicenter, Multinational Study to Assess the Feasibility of Switching Therapy From Pramipexole or Ropinirole to the Rotigotine Transdermal System and Its Effect on Motor and Non-Motor Symptoms in Subjects With Advanced Idiopathic Parkinson's Disease Phase 4 Completed NCT01711866 Phase 4 Rotigotine
36 Open-label, Multicenter, Effectiveness and Safety Study of Once Daily AZILECT® as Mono- or Adjunct Therapy in Patients With Idiopathic Parkinson's Disease (PD) Completed NCT00399477 Phase 4 rasagiline mesylate;Rasagiline mesylate plus Mirapex;Rasagiline mesylate with Levodopa;Rasagiline mesylate with Requip
37 Multicentre, Randomised, Double-Blind Study to Compare Stalevo to Levodopa/Carbidopa in Patients With Parkinson's Disease Experiencing Symptoms of Early Wearing-Off Completed NCT00125567 Phase 4 Stalevo (levodopa/carbidopa/entacapone);Levodopa/carbidopa
38 A Long-term Health Economics Study of Intraduodenal Levodopa (Duodopa®) in Routine Care for Patients With Advanced Idiopathic Parkinson's Disease With Severe Motor Fluctuations and Hyper-/Dyskinesia Completed NCT00141518 Phase 4 Levodopa-carbidopa intestinal gel (LCIG)
39 An Explorative, Multicenter, Open-label Pilot Trial With Neupro® (Rotigotine Transdermal Patch) Once Daily Treatment Administered Perioperatively in Patients With Idiopathic Parkinson's Disease Completed NCT00594464 Phase 4 Rotigotine
40 Effect of Undenatured Cysteine-Rich Whey Protein Isolate (HMS 90®) in Patients With Parkinson's Disease: Changes in Biomarkers of Oxidative Stress, Profiles of Plasma Amino Acids and Their Derivatives and Brain Function Completed NCT01662414 Phase 4
41 Multicenter, Double-blind, Placebo-controlled, Parallel-group, Phase IV Study to Assess the Effect of Rotigotine on Non-motor Symptoms in Patients With Idiopathic Parkinson's Disease Completed NCT01300819 Phase 4 Rotigotine
42 A Multicenter, Multinational, Double-Blind, Placebo-Controlled, 3-Arm, Phase 4 Study To Evaluate The Efficacy Of Rotigotine On Parkinson's Disease-Associated Apathy, Motor Symptoms, And Mood Completed NCT01782222 Phase 4 Rotigotine
43 Reversibility of Olfactory Loss in Patients With Idiopathic Parkinson's Disease Following Treatment With Rasagiline Completed NCT00902941 Phase 4 Azilect 1mg;Placebo
44 Intravenous Young Fresh Frozen Plasma (yFFP) Investigational Treatment for Parkinson's Disease - Randomized Controlled Study Completed NCT04202757 Phase 4
45 A Randomised, Double-blind, Placebo-controlled Study to Evaluate if Rasagiline Can Improve Depressive Symptoms and Cognitive Function in Non-demented, Idiopathic Parkinson's Disease Patients: ACCORDO Study Completed NCT01055379 Phase 4 Rasagiline;Placebo
46 An Open-Label Study of Aripiprazole to Evaluate the Safety and Tolerability in Patients With Psychosis Associated With Parkinson's Disease Completed NCT00095810 Phase 4 aripiprazole
47 A 24-Week, Multicenter, Randomized, Double-blind, Placebo-Controlled, Add-on, Parallel-Group Study to Assess the Effect of Rasagiline on Cognition in Patients With Parkinson's Disease Completed NCT01723228 Phase 4 Rasagiline;Placebo
48 A Multicenter, Multinational, Double-Blind, Placebo-Controlled, 2-Arm Study to Evaluate the Efficacy of Rotigotine on Parkinson's Disease-Associated Pain Completed NCT01744496 Phase 4 Rotigotine;Placebo
49 Study to Compare the Effect of Treatment With Carbidopa/Levodopa/Entacapone on the Quality of Life of Patients With Parkinson's Disease. Completed NCT00143026 Phase 4 carbidopa, levodopa, entacapone
50 URGE-PD: A Multi-site, Double-blind, Randomized, Placebo Controlled Trial of Solifenacin Succinate (VESIcare) for the Treatment of Overactive Bladder in Parkinson's Disease Completed NCT01018264 Phase 4 solifenacin succinate (VESIcare);placebo

Search NIH Clinical Center for Parkinson Disease, Late-Onset

Inferred drug relations via UMLS 71 / NDF-RT 50 :

2-Bromoergocryptine Mesylate
Amantadine Hydrochloride
Apomorphine hydrochloride
benztropine mesylate
Biperiden Hydrochloride
biperiden lactate
Pergolide Mesylate
Pramipexole dihydrochloride
Ropinirole hydrochloride
selegiline hydrochloride
Trihexyphenidyl Hydrochloride

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Parkinson Disease, Late-Onset cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: parkinson disease

Genetic Tests for Parkinson Disease, Late-Onset

Genetic tests related to Parkinson Disease, Late-Onset:

# Genetic test Affiliating Genes
1 Parkinson Disease 29
2 Parkinson Disease, Late-Onset 29 ADH1C ATXN2 ATXN8OS GBA GLUD2 MAPT NR4A2 SNCAIP TBP

Anatomical Context for Parkinson Disease, Late-Onset

MalaCards organs/tissues related to Parkinson Disease, Late-Onset:

Brain, Subthalamic Nucleus, Testes, Cortex, Eye, Spinal Cord, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Parkinson Disease, Late-Onset:
# Tissue Anatomical CompartmentCell Relevance
1 Brain Substantia Nigra pars Compacta Adult Dopaminergic Neurons Affected by disease, potential therapeutic candidate
2 Brain Forebrain White Matter Fibrous Astrocyte Cells Potential therapeutic candidate
3 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
4 Brain Neocortex Protoplasmic Astrocyte Cells Potential therapeutic candidate
5 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Parkinson Disease, Late-Onset

Articles related to Parkinson Disease, Late-Onset:

(show top 50) (show all 12772)
# Title Authors PMID Year
The need for appropriate genotyping strategies for glucocerebrosidase mutations in cohorts with Parkinson disease. 54 61 6 56
18541817 2008
Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders. 56 54 61 6
18332251 2008
Glucocerebrosidase mutations and risk of Parkinson disease in Chinese patients. 54 56 6 61
17620502 2007
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. 54 6 56
19286695 2009
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease. 54 56 6
12761037 2003
Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset. 56 6
19826450 2010
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. 6 61 46
18252210 2008
Serotonin 2A receptors and visual hallucinations in Parkinson disease. 56 54 61
20385906 2010
Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset. 56 61 54
18434642 2008
Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian population. 54 61 56
16476943 2006
Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. 54 56 61
14570706 2003
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. 54 61 56
12669033 2003
Mutations in NR4A2 associated with familial Parkinson disease. 61 54 6
12496759 2003
Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease. 56 54 61
11710889 2001
Genetic polymorphism of cytochrome P450 2D6 in idiopathic Parkinson disease and diffuse Lewy body disease. 61 54 56
9316701 1994
The MC1R melanoma risk variant p.R160W is associated with Parkinson disease. 56 61
25631192 2015
The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial. 61 56
21280081 2011
Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study. 56 61
20837857 2010
Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus. 61 56
20697102 2010
Association of pyridoxal kinase and Parkinson disease. 56 61
20373354 2010
The PDXK rs2010795 variant is not associated with Parkinson disease in Italy. 61 56
20373357 2010
LRRK2 and GBA mutations differentially affect the initial presentation of Parkinson disease. 56 61
19458969 2010
Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. 61 56
20035503 2009
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. 54 56
19846850 2009
Family history of melanoma and Parkinson disease risk. 61 56
19841380 2009
Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18. 56 61
19327735 2009
FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression. 6 54
19133659 2009
Genomewide association study for susceptibility genes contributing to familial Parkinson disease. 61 56
18985386 2009
Genetic association study of synphilin-1 in idiopathic Parkinson's disease. 54 6
18366718 2008
Factors associated with dopaminergic drug-related pathological gambling in Parkinson disease. 61 56
17296836 2007
Mitochondria in Parkinson disease: back in fashion with a little help from genetics. 61 56
16682534 2006
Early descriptions of Parkinson disease in ancient China. 56 61
16682554 2006
GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. 54 56
16315267 2005
High-resolution whole-genome association study of Parkinson disease. 56 61
16252231 2005
Association between family history of dementia and hallucinations in Parkinson disease. 61 56
15911796 2005
Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews. 56 54
15525722 2004
No evidence for heritability of Parkinson disease in Swedish twins. 61 56
15277625 2004
Prevalence of Parkinson disease in Singapore: Chinese vs Malays vs Indians. 61 56
15184604 2004
Absence of NR4A2 exon 1 mutations in 108 families with autosomal dominant Parkinson disease. 61 6
15184637 2004
Parkinson Disease Overview 61 6
20301402 2004
Extended mutation analysis and association studies of Nurr1 (NR4A2) in Parkinson disease. 61 6
15079038 2004
Genetic testing in spinocerebellar ataxia in Taiwan: expansions of trinucleotide repeats in SCA8 and SCA17 are associated with typical Parkinson's disease. 6 54
14756671 2004
A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease. 54 6
14991826 2004
Progressive supranuclear palsy and Parkinson's disease in a family with a new mutation in the tau gene. 6 54
14991829 2004
Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families. 56 61
12925570 2003
Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. 61 56
12618962 2003
Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study. 54 56
12490535 2003
Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations. 56 61
12058349 2002
Segregation analysis of Parkinson disease revealing evidence for a major causative gene. 61 56
11977177 2002
Age at onset in two common neurodegenerative diseases is genetically controlled. 61 56
11875758 2002

Variations for Parkinson Disease, Late-Onset

ClinVar genetic disease variations for Parkinson Disease, Late-Onset:

6 (show top 50) (show all 99) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TBP TBP, (CAG)n REPEAT EXPANSIONNT expansion Pathogenic,risk factor 562072
2 ATXN8 , ATXN8OS ATXN8, (CAG)n REPEAT EXPANSIONNT expansion Pathogenic,risk factor 562101
3 GBA , LOC106627981 NM_000157.4(GBA):c.1294T>A (p.Trp432Arg)SNV Pathogenic 599275 rs1557901552 1:155205566-155205566 1:155235775-155235775
4 GBA NM_000157.4(GBA):c.762-1G>CSNV Pathogenic 633240 rs1237637353 1:155207370-155207370 1:155237579-155237579
5 GBA GRCh37/hg19 1q22(chr1:155188179-155209868)copy number loss Pathogenic 813310 1:155188179-155209868
6 ATXN3 NM_004993.5(ATXN3):c.892_894CAG(8_36) (p.Gln298_Gln305=)NT expansion Pathogenic,risk factor 3551 rs193922928 14:92537355-92537357 14:92071011-92071013
7 GBA NM_000157.4(GBA):c.1448T>C (p.Leu483Pro)SNV Pathogenic,risk factor 4288 rs421016 1:155205043-155205043 1:155235252-155235252
8 GBA NM_000157.4(GBA):c.1504C>T (p.Arg502Cys)SNV Pathogenic 4295 rs80356771 1:155204987-155204987 1:155235196-155235196
9 GBA NM_000157.4(GBA):c.1604G>A (p.Arg535His)SNV Pathogenic 4311 rs75822236 1:155204793-155204793 1:155235002-155235002
10 GBA NM_000157.4(GBA):c.887G>A (p.Arg296Gln)SNV Pathogenic 4328 rs78973108 1:155207244-155207244 1:155237453-155237453
11 MAPT NM_016835.4(MAPT):c.1853C>T (p.Pro618Leu)SNV Pathogenic 14245 rs63751273 17:44087755-44087755 17:46010389-46010389
12 MAPT NM_016835.4(MAPT):c.2167C>T (p.Arg723Trp)SNV Pathogenic 14247 rs63750424 17:44101427-44101427 17:46024061-46024061
13 MAPT NM_016835.4(MAPT):c.1788T>G (p.Asn596Lys)SNV Pathogenic 14253 rs63750756 17:44087690-44087690 17:46010324-46010324
14 GLUD2 NM_012084.4(GLUD2):c.1492T>G (p.Ser498Ala)SNV Pathogenic 29936 rs9697983 X:120183030-120183030 X:121049176-121049176
15 ATXN2 NP_002964.3:p.Gln166(>=33)NT expansion Pathogenic,risk factor 65668
16 MAPT NM_016835.4(MAPT):c.1835_1837ATA[1] (p.Asn613del)short repeat Pathogenic,risk factor 98243 rs63751392 17:44087737-44087739 17:46010371-46010373
17 GBA NM_000157.4(GBA):c.115+1G>ASNV Pathogenic 93445 rs104886460 1:155210420-155210420 1:155240629-155240629
18 VPS13C NM_020821.3(VPS13C):c.9568G>T (p.Glu3190Ter)SNV Pathogenic 222069 rs869312810 15:62174851-62174851 15:61882652-61882652
19 VPS13C NM_020821.3(VPS13C):c.8445+2T>GSNV Pathogenic 222067 rs869312809 15:62207830-62207830 15:61915631-61915631
20 VPS13C NM_020821.3(VPS13C):c.4777del (p.Gln1593fs)deletion Pathogenic 222071 rs869312811 15:62239491-62239491 15:61947292-61947292
21 VPS13C NM_020821.3(VPS13C):c.4165G>C (p.Gly1389Arg)SNV Pathogenic 222070 rs369100678 15:62250807-62250807 15:61958608-61958608
22 VPS13C NM_020821.3(VPS13C):c.806_807insCAGA (p.Arg269fs)insertion Pathogenic 222068 rs879253853 15:62305256-62305257 15:62013057-62013058