Aliases & Classifications for Paronychia

MalaCards integrated aliases for Paronychia:

Name: Paronychia 12 77 56 45 15 17
Paronychia Inflammation 12 74
Onychia and Paronychia of Finger 12
Onychia and Paronychia of Toe 12
Fungal Nail Infection 12
Infected Nailfold 12
Onychomycosis 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13117
MeSH 45 D010304
NCIt 51 C79702
SNOMED-CT 69 71906005
ICD10 34 L03.0

Summaries for Paronychia

Disease Ontology : 12 A nail disease characterized by often-tender bacterial or fungal hand infection or foot infection due to either bacteria or fungus (Candida albicans) where the nail and skin meet at the side or the base of a finger or toe nail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia). Puss is usually present, along with gradual thickening and browning discoloration of the nail plate.

MalaCards based summary : Paronychia, also known as paronychia inflammation, is related to candidal paronychia and neuropathy, hereditary sensory and autonomic, type iia. An important gene associated with Paronychia is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Irinotecan and Phylloquinone have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 77 Paronychia is a nail disease that is an often-tender bacterial or fungal infection of the hand or foot... more...

Related Diseases for Paronychia

Diseases related to Paronychia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 candidal paronychia 12.1
2 neuropathy, hereditary sensory and autonomic, type iia 11.2
3 pemphigus 10.3
4 pyogenic granuloma 10.3
5 pemphigus vulgaris, familial 10.3
6 pemphigus vulgaris 10.3
7 leishmaniasis 10.2
8 cutaneous leishmaniasis 10.2
9 squamous cell carcinoma 10.1
10 dermatitis 10.1
11 contact dermatitis 10.1
12 luminal breast carcinoma 10.1 EGFR MTOR
13 geographic tongue 10.1 EGFR MTOR
14 pulmonary blastoma 10.0 EGFR KRAS
15 mucinous lung adenocarcinoma 10.0 EGFR KRAS
16 adenosquamous lung carcinoma 10.0 EGFR KRAS
17 mucinous adenocarcinoma 10.0 EGFR KRAS
18 bronchiolo-alveolar adenocarcinoma 10.0 EGFR KRAS
19 estrogen-receptor positive breast cancer 10.0 EGFR MTOR
20 neutropenia 10.0
21 osteomyelitis 10.0
22 allergic contact dermatitis 10.0
23 pyoderma 10.0
24 psoriasis 10.0
25 lung benign neoplasm 10.0 EGFR KRAS
26 adenosquamous carcinoma 10.0 EGFR KRAS
27 colonic disease 9.9 EGFR KRAS
28 colorectal adenocarcinoma 9.9 EGFR KRAS
29 endometrial adenocarcinoma 9.9 EGFR KRAS
30 intrahepatic cholangiocarcinoma 9.8 EGFR KRAS
31 autoimmune disease 9.8
32 keloid formation 9.8
33 ocular cicatricial pemphigoid 9.8
34 small cell cancer of the lung 9.8
35 buerger disease 9.8
36 lung cancer 9.8
37 osteogenic sarcoma 9.8
38 diabetes mellitus 9.8
39 hepatitis 9.8
40 keloids 9.8
41 leukemia 9.8
42 nephrolithiasis 9.8
43 fusariosis 9.8
44 lymphoma 9.8
45 pseudopterygium 9.8
46 blastomycosis 9.8
47 balanitis 9.8
48 bronchus cancer 9.8
49 cheilitis 9.8
50 pericarditis 9.8

Graphical network of the top 20 diseases related to Paronychia:



Diseases related to Paronychia

Symptoms & Phenotypes for Paronychia

GenomeRNAi Phenotypes related to Paronychia according to GeneCards Suite gene sharing:

27 (show all 32)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.65 EGFR MTOR KRAS
2 Decreased viability GR00106-A-0 10.65 KRAS
3 Decreased viability GR00221-A-1 10.65 EGFR MTOR KRAS MAP2K7
4 Decreased viability GR00221-A-2 10.65 KRAS
5 Decreased viability GR00221-A-3 10.65 WNK1
6 Decreased viability GR00221-A-4 10.65 EGFR MTOR WNK1
7 Decreased viability GR00301-A 10.65 KRAS
8 Decreased viability GR00342-S-1 10.65 MTOR MAP2K7
9 Decreased viability GR00342-S-2 10.65 MTOR
10 Decreased viability GR00381-A-1 10.65 KRAS
11 Decreased viability GR00402-S-2 10.65 EGFR MTOR WNK1 KRAS MAP2K7
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 10.27 KRAS
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.27 KRAS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10.27 KRAS
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.27 MTOR
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 10.27 KRAS
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.27 KRAS
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 10.27 KRAS
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 10.27 KRAS
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 10.27 KRAS WNK1
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.27 KRAS MTOR WNK1
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.27 MTOR
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 10.27 KRAS
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.27 WNK1
25 Decreased viability with paclitaxel GR00179-A-1 9.85 EGFR MTOR
26 Decreased viability with paclitaxel GR00179-A-2 9.85 MTOR
27 Decreased viability with paclitaxel GR00179-A-3 9.85 EGFR MTOR
28 Decreased substrate adherent cell growth GR00193-A-2 9.8 EGFR MAP2K7 MTOR WNK1
29 Decreased substrate adherent cell growth GR00193-A-3 9.8 MAP2K7 WNK1
30 Decreased cell migration GR00055-A-1 9.58 EGFR KRAS MTOR
31 Increased cell migration GR00055-A-3 9.13 EGFR KRAS MTOR
32 shRNA abundance <= 50% GR00343-S 9.1 EGFR KRAS MAP2K7 MTOR SERPINA3 WNK1

MGI Mouse Phenotypes related to Paronychia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.26 EGFR KRAS MTOR WNK1
2 renal/urinary system MP:0005367 8.92 EGFR KRAS MTOR WNK1

Drugs & Therapeutics for Paronychia

Drugs for Paronychia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Irinotecan Approved, Investigational Phase 4,Phase 2 100286-90-6, 97682-44-5 60838
2
Phylloquinone Approved, Investigational Phase 4 84-80-0
3
leucovorin Approved Phase 4,Phase 2 58-05-9 143 6006
4 Menaquinone Approved, Investigational Phase 4 1182-68-9
5
Cetuximab Approved Phase 4 205923-56-4 56842117 2333
6
Fluorouracil Approved Phase 4,Phase 2 51-21-8 3385
7
afatinib Approved Phase 4,Not Applicable 850140-72-6, 439081-18-2 10184653
8
Amorolfine Approved, Investigational Phase 4 78613-35-1
9
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
10
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
12 Immunoglobulins Phase 4
13 Vitamin K Phase 4
14 naphthoquinone Phase 4
15 Vitamin B Complex Phase 4,Phase 2
16 Folate Phase 4,Phase 2
17 Mitogens Phase 4,Not Applicable
18 Vitamin B9 Phase 4,Phase 2
19 Antibodies Phase 4
20 Antibodies, Monoclonal Phase 4
21 Antineoplastic Agents, Immunological Phase 4,Phase 2
22 Vitamin K 1 Phase 4
23 Vitamins Phase 4,Phase 2
24 Protein Kinase Inhibitors Phase 4,Phase 2,Not Applicable
25 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
26 Antifungal Agents Phase 4
27
Clindamycin Approved, Vet_approved Phase 2 18323-44-9 29029
28
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
29
Amoxicillin Approved, Vet_approved Phase 2,Not Applicable 26787-78-0 33613
30
Silver sulfadiazine Approved, Vet_approved Phase 2 22199-08-2 441244
31
Panitumumab Approved, Investigational Phase 2 339177-26-3 50070211
32
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
33
Petrolatum Approved, Investigational Phase 2 8009-03-8
34
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
35
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
36
Hydroxyzine Approved Phase 2 68-88-2 3658
37
Sulfadiazine Approved, Investigational, Vet_approved Phase 2 68-35-9 5215
38
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
39
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
40
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
41
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
42
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
43
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
44
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
45
Decitabine Approved, Investigational Phase 2 2353-33-5 451668
46 Lycopene Approved, Investigational Phase 2 502-65-8 53477748
47 Tomato Approved Phase 2
48
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
49
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
50 Emollients Phase 2,Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Unknown status NCT01315990 Phase 4 FOLFIRI + Cetuximab
2 A Pilot Study - Safety and Efficacy of Nailprotex® for Onychomycosis Treatment Completed NCT02464826 Phase 4 Nailprotex
3 Afatinib Treatment for Patients With EGFR Mutation Positive NSCLC Who Are Age 70 or Older Completed NCT02514174 Phase 4 Afatinib
4 Comparison Between Long-pulsed Nd:YAG, Amorolfine and Combination Treatment in Treating Non-dermatophyte Onychomycosis Recruiting NCT02812043 Phase 4 Amorolfine
5 Afatinib in EGFR+NSCLC (Recurrent or Stage IV) - Patients With Poor Performance Status (ECOG 2 or 3) Terminated NCT02695290 Phase 4 Afatinib
6 A Trial to Evaluate the Efficacy and Safety of Two Concentrations of VBP-926 Solution for the Treatment of Chemotherapy-associated Paronychia in Cancer Patients Completed NCT03207906 Phase 2 VBP-926
7 Skin Toxicity Treatment in Metastatic Colorectal Cancer (mCRC) Patients Receiving Panitumumab + Irinotecan-based Therapy Completed NCT00332163 Phase 2 Irinotecan;FOLFIRI;Pre-emptive Skin Treatment;Reactive Skin Treatment
8 Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO Completed NCT01465802 Phase 2 Dacomitinib;Dacomitinib;Doxycycline;Probiotic;Alclometasone cream
9 A Study of Management of Tarceva - Induced Rash in Patients With Non-Small Cell Lung Cancer. Completed NCT00531934 Phase 2 Doxycline;erlotinib [Tarceva]
10 Safety and Efficacy Study of mFOLFOX6 + Panitumumab Combination Therapy and 5-FU/LV + Panitumumab Combination Therapy in Participants With Chemotherapy-naïve Unresectable Advanced Recurrent Colorectal Carcinoma Completed NCT02337946 Phase 2 oxaliplatin (OXA), levofolinate calcium (l-LV), 5-FU, panitumumab;oxaliplatin (OXA), levofolinate calcium (l-LV), 5-FU, panitumumab
11 An Efficacy and Safety Study of Decitabine in Participants With Myelodysplastic Syndrome (MDS) Completed NCT00744757 Phase 2 Decitabine
12 Panitumumab Skin Toxicity Prevention Trial Recruiting NCT03167268 Phase 2 Lycopene
13 Preventive Effect of EGF Cream for Cutaneous Adverse Event of EGFR Inhibitors Unknown status NCT03051880 Not Applicable Repair Control EGF®;Cream without rhEGF
14 Impact of Antibiotic Treatment of Group A Streptococcal Blistering Distal Dactylitis in Children Completed NCT02624882 Not Applicable
15 GIOTRIF in First Line Therapy of Advanced NSCLC With EGFR-mutations Completed NCT02047903 Afatinib
16 An Observational Study of Erlotinib Plus Gemcitabine in Patients With Metastatic Pancreatic Cancer Completed NCT01782690 erlotinib;gemcitabine
17 Effect of Zanthoxylum Nitidum Tincture for Paronychia Caused by Afatinib Not yet recruiting NCT03908892 Not Applicable zanthoxylum nitidum tincture;tetracycline ointment

Search NIH Clinical Center for Paronychia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: paronychia

Genetic Tests for Paronychia

Anatomical Context for Paronychia

MalaCards organs/tissues related to Paronychia:

42
Skin, Bone, Testes, T Cells, Colon, Pancreas, Thyroid

Publications for Paronychia

Articles related to Paronychia:

(show top 50) (show all 238)
# Title Authors Year
1
Paronychia Associated with Ledipasvir/Sofosbuvir for Hepatitis C Treatment. ( 30881576 )
2019
2
Using a novel scoring system for paronychia related to oncologic treatments (SPOT) for assessing paronychia severity and its correlation with pain index and quality of life. ( 29894010 )
2019
3
Papulopustules and paronychia in a lung carcinoma. ( 30297249 )
2019
4
Case series showing the efficacy of 5-aminolaevulinic acid photodynamic therapy for epidermal growth factor receptor inhibitor-induced paronychia and pyogenic granuloma-like lesions. ( 30298920 )
2019
5
Mucous membrane pemphigoid-associated paronychia with onychomadesis. ( 30674299 )
2019
6
Chronic paronychia with subungual purpura. ( 30829296 )
2019
7
Are topical beta-blockers really effective "in real life" for targeted therapy-induced paronychia. ( 30847700 )
2019
8
Atypical acute paronychia. ( 31106770 )
2019
9
Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease. ( 29560011 )
2018
10
Febrile neutropenia with bacterial paronychia. ( 29531738 )
2018
11
Primary Cutaneous CD8+ T-cell Lymphoma, an Indolent and Locally Aggressive Form Mimicking Paronychia. ( 28984695 )
2018
12
Nail braces for severe paronychia induced by epidermal growth factor receptor inhibitors: An alternative to nail extraction. ( 28987490 )
2018
13
Paronychia with Sporangium Formation Causing an Ingrown Toenail A Rare Case Report. ( 29116824 )
2018
14
Topical Timolol for Paronychia and Pseudopyogenic Granuloma in Patients Treated With Epidermal Growth Factor Receptor Inhibitors and Capecitabine. ( 29117285 )
2018
15
Topical betaxolol for treating relapsing paronychia with pyogenic granuloma-like lesions induced by epidermal growth factor receptor inhibitors. ( 29339238 )
2018
16
Retronychia a little-known cause of paronychia: A report of two cases in adolescent patients. ( 29479729 )
2018
17
Purulent Pericarditis Due to Paronychia in a 16-Month-Old Child: A Nail-Biting Story. ( 29506451 )
2018
18
Relationship between Paronychia and Drug Concentrations of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors. ( 29902802 )
2018
19
Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma. ( 30258794 )
2018
20
A Proposal for a New Severity Index for the Evaluation of Chronic Paronychia. ( 30643778 )
2018
21
Paronychia-like digital metastases of osteosarcoma. ( 27495265 )
2017
22
Paronychia and onychomadesis due to pemphigus vulgaris. ( 27506502 )
2017
23
Non-healing ulcerative paronychia. ( 28017401 )
2017
24
Recurrent Paronychia as a Presenting Manifestation of Pemphigus Vulgaris: A Case Report. ( 28611998 )
2017
25
Acute and Chronic Paronychia. ( 28671378 )
2017
26
Paronychia: What You Should Know. ( 28671380 )
2017
27
Neonatal Acute Paronychia. ( 28720045 )
2017
28
Chemotherapy-associated paronychia treated with 2% povidone-iodine: a series of cases. ( 28721095 )
2017
29
Chinese Medicine Treatment for Afatinib-Induced Paronychia. ( 28948057 )
2017
30
Pediatric Dermatology Photoquiz: Refractory Purulent Paronychia in a Young Girl. Paronychial cutaneous leishmaniasis. ( 26758096 )
2016
31
Antibiotic Overuse and Paronychia: A Teachable Moment. ( 26569127 )
2016
32
Effective treatments for paronychia caused by oncology pharmacotherapy. ( 26596962 )
2016
33
Chronic paronychia treatment: Square flap technique. ( 26946988 )
2016
34
Acute felon and paronychia: Antibiotics not necessary after surgical treatment. Prospective study of 46 patients. ( 27117023 )
2016
35
Paronychia and granulation tissue formation during treatment with isotretinoin. ( 27192525 )
2016
36
Congenital Malalignment of the Great Toenails With Acute Paronychia. ( 27396767 )
2016
37
Periungual Abscess Caused by Citrobacter braakii in a Patient with Chronic Paronychia. ( 27489449 )
2016
38
sQUIZ your knowledge: Chronic paronychia of the third toe. ( 27789424 )
2016
39
Toenail paronychia. ( 27810017 )
2016
40
Paronychia-like cutaneous leishmaniasis. ( 26632940 )
2015
41
1064 Nd:YAG laser for the treatment of chronic paronychia: a pilot study. ( 24326744 )
2015
42
Tips to treat the 5 most common nail disorders: brittle nails, onycholysis, paronychia, psoriasis, onychomycosis. ( 25828710 )
2015
43
Treatment and prevention of paronychia using a new combination of topicals: report of 30 cases. ( 25854670 )
2015
44
HPLC-UV/DAD and ESI-MS(n) analysis of flavonoids and antioxidant activity of an Algerian medicinal plant: Paronychia argentea Lam. ( 25910047 )
2015
45
Evaluation of role of Candida in patients with chronic paronychia. ( 26087081 )
2015
46
Chemotherapy-associated paronychia treated with a dilute povidone-iodine/dimethylsulfoxide preparation. ( 26445556 )
2015
47
Ungual squamous cell carcinoma mimicking a chronic paronychia: clinical, pathological and radiological correlation. ( 26632936 )
2015
48
Images in clinical medicine. Cutaneous leishmaniasis with a paronychia-like lesion. ( 25354107 )
2014
49
Atypical chronic sterile paronychia leading to tissue and joint space destruction in a patient with thromboangiitis obliterans. ( 23127186 )
2014
50
Oleanane type glycosides from Paronychia anatolica subsp. balansae. ( 24321579 )
2014

Variations for Paronychia

Expression for Paronychia

Search GEO for disease gene expression data for Paronychia.

Pathways for Paronychia

Pathways related to Paronychia according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 EGFR KRAS MAP2K7 MTOR WNK1
2
Show member pathways
13.15 EGFR KRAS MTOR WNK1
3
Show member pathways
12.96 EGFR KRAS MAP2K7 MTOR
4
Show member pathways
12.69 EGFR KRAS MAP2K7 MTOR
5
Show member pathways
12.69 EGFR KRAS MAP2K7 MTOR
6 12.61 EGFR KRAS MTOR
7
Show member pathways
12.58 KRAS MAP2K7 MTOR
8
Show member pathways
12.55 EGFR KRAS MAP2K7 MTOR
9
Show member pathways
12.54 EGFR KRAS MTOR
10 12.54 EGFR KRAS MAP2K7
11
Show member pathways
12.51 EGFR KRAS MTOR
12
Show member pathways
12.49 KRAS MAP2K7 MTOR
13
Show member pathways
12.46 EGFR KRAS MAP2K7
14
Show member pathways
12.35 EGFR KRAS MAP2K7 MTOR
15 12.31 EGFR KRAS MTOR
16
Show member pathways
12.29 EGFR KRAS MTOR
17
Show member pathways
12.29 EGFR KRAS MAP2K7 MTOR
18
Show member pathways
12.23 EGFR KRAS MTOR
19
Show member pathways
12.22 KRAS MAP2K7 MTOR
20
Show member pathways
12.21 EGFR KRAS MAP2K7
21
Show member pathways
12.2 EGFR KRAS MTOR
22
Show member pathways
12.19 EGFR KRAS MTOR
23
Show member pathways
12.15 EGFR KRAS MAP2K7 MTOR
24
Show member pathways
12.11 EGFR KRAS MAP2K7 MTOR
25 12.07 EGFR KRAS MTOR
26
Show member pathways
12.07 EGFR KRAS MAP2K7 MTOR
27
Show member pathways
12.04 KRAS MAP2K7 MTOR
28
Show member pathways
12.01 EGFR KRAS MAP2K7
29
Show member pathways
11.99 EGFR KRAS MTOR
30 11.96 EGFR KRAS MTOR
31 11.92 EGFR KRAS MTOR
32 11.91 EGFR KRAS MTOR
33
Show member pathways
11.89 EGFR KRAS MAP2K7
34
Show member pathways
11.86 EGFR KRAS MTOR
35
Show member pathways
11.8 EGFR KRAS MTOR
36 11.65 EGFR KRAS MTOR
37 11.62 EGFR KRAS MTOR
38 11.57 EGFR KRAS
39 11.51 EGFR MTOR
40 11.44 EGFR KRAS
41 11.39 EGFR MAP2K7
42 11.35 EGFR KRAS
43 11.31 EGFR KRAS MTOR
44 11.3 EGFR KRAS
45 11.18 KRAS MTOR
46 11.11 KRAS MTOR
47 11.05 EGFR KRAS
48 10.84 EGFR KRAS MAP2K7 MTOR
49 10.7 EGFR MAP2K7
50 10.61 EGFR KRAS MTOR

GO Terms for Paronychia

Biological processes related to Paronychia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.56 EGFR MAP2K7 MTOR WNK1
2 liver development GO:0001889 9.49 EGFR KRAS
3 peptidyl-threonine phosphorylation GO:0018107 9.48 MTOR WNK1
4 positive regulation of MAP kinase activity GO:0043406 9.46 EGFR KRAS
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 EGFR MTOR
6 cellular response to amino acid stimulus GO:0071230 9.4 EGFR MTOR
7 visual learning GO:0008542 9.37 KRAS MTOR
8 positive regulation of protein phosphorylation GO:0001934 9.33 EGFR KRAS MTOR
9 response to osmotic stress GO:0006970 9.32 EGFR MAP2K7
10 protein phosphorylation GO:0006468 9.26 EGFR MAP2K7 MTOR WNK1
11 protein autophosphorylation GO:0046777 8.8 EGFR MTOR WNK1

Molecular functions related to Paronychia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.67 EGFR MAP2K7 MTOR WNK1
2 protein serine/threonine kinase activity GO:0004674 9.5 MAP2K7 MTOR WNK1
3 kinase activity GO:0016301 9.46 EGFR MAP2K7 MTOR WNK1
4 nucleotide binding GO:0000166 9.43 EGFR KRAS MTOR
5 protein phosphatase binding GO:0019903 9.4 EGFR MAP2K7
6 protein kinase activity GO:0004672 9.26 EGFR MAP2K7 MTOR WNK1
7 protein kinase binding GO:0019901 8.92 EGFR MAP2K7 MTOR WNK1

Sources for Paronychia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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