MCID: PRS145
MIFTS: 30

Parosteal Osteosarcoma

Categories: Bone diseases, Cancer diseases
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Aliases & Classifications for Parosteal Osteosarcoma

MalaCards integrated aliases for Parosteal Osteosarcoma:

Name: Parosteal Osteosarcoma 11 14 71
Juxtacortical Osteosarcoma 11 16
Parosteal Osteogenic Sarcoma 11
Osteosarcoma, Juxtacortical 43

Classifications:



External Ids:

Disease Ontology 11 DOID:3373
MeSH 43 D018217
NCIt 49 C8969
SNOMED-CT 68 91242000
UMLS 71 C0206642

Summaries for Parosteal Osteosarcoma

MalaCards based summary: Parosteal Osteosarcoma, also known as juxtacortical osteosarcoma, is related to periosteal osteogenic sarcoma and telangiectatic osteogenic sarcoma. An important gene associated with Parosteal Osteosarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are DNA damage_ATM/ATR regulation of G1/S checkpoint and Bladder cancer. Affiliated tissues include bone, lung and liver, and related phenotypes are limbs/digits/tail and neoplasm

Related Diseases for Parosteal Osteosarcoma

Diseases related to Parosteal Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 periosteal osteogenic sarcoma 32.2 SATB2 MDM2
2 telangiectatic osteogenic sarcoma 30.7 MDM2 COPS3
3 myositis ossificans 30.6 SATB2 MDM2 CDK4
4 extraosseous osteosarcoma 30.5 SATB2 MDM2 CDK4
5 conventional osteosarcoma 30.3 SATB2 MDM2 EWSR1 COPS3 CDK4
6 connective tissue benign neoplasm 30.2 MDM2 EWSR1 CDK4
7 chondrosarcoma 30.1 MDM2 EWSR1 CDK4
8 fibrosarcomatous osteosarcoma 30.1 SATB2 RBM4B MDM2
9 bone sarcoma 29.9 MDM2 EWSR1 CDK4
10 mesenchymal cell neoplasm 29.9 MDM2 EWSR1
11 liposarcoma 29.9 MDM2 FRS2 EWSR1 CDK4
12 well-differentiated liposarcoma 29.9 MDM2 FRS2 EWSR1 CDK4
13 malignant fibrous histiocytoma 29.8 RECQL4 MDM2 EWSR1 CDK4
14 peripheral osteosarcoma 29.3 SNRNP25 SATB2 MDM2 GNAS FRS2 EMILIN1
15 bone osteosarcoma 28.1 SNRNP25 SATB2 RECQL4 MDM2 KCNMB4 GNAS
16 childhood parosteal osteogenic sarcoma 11.2
17 osteogenic sarcoma 11.1
18 osteochondroma 10.5
19 fibrodysplasia ossificans progressiva 10.4
20 myositis 10.4
21 kidney liposarcoma 10.3 MDM2 CDK4
22 mediastinum liposarcoma 10.3 MDM2 CDK4
23 childhood liposarcoma 10.3 MDM2 CDK4
24 infiltrating lipoma 10.3 MDM2 CDK4
25 spindle cell liposarcoma 10.3 MDM2 CDK4
26 pancreas sarcoma 10.3 MDM2 CDK4
27 chest wall lipoma 10.3 MDM2 CDK4
28 adult liposarcoma 10.2 MDM2 CDK4
29 lipoma of spermatic cord 10.2 MDM2 CDK4
30 inflammatory liposarcoma 10.2 MDM2 CDK4
31 malignant inflammatory fibrous histiocytoma 10.2 MDM2 CDK4
32 fibrous dysplasia 10.2
33 primary bone cancer 10.2
34 paratesticular lipoma 10.2 MDM2 CDK4
35 spindle cell lipoma 10.2 MDM2 CDK4
36 mixed liposarcoma 10.2 MDM2 CDK4
37 gastric liposarcoma 10.2 MDM2 CDK4
38 heart sarcoma 10.2 MDM2 CDK4
39 retroperitoneal sarcoma 10.2 MDM2 CDK4
40 large intestine lipoma 10.2 MDM2 CDK4
41 lipoma of colon 10.2 MDM2 CDK4
42 appendiceal neoplasm 10.2 SATB2 GNAS
43 infiltrating angiolipoma 10.2 MDM2 CDK4
44 osseous heteroplasia, progressive 10.2
45 down syndrome 10.2
46 rapidly involuting congenital hemangioma 10.2
47 sarcoma 10.2
48 bone cancer 10.2
49 fibrous histiocytoma 10.2
50 cutaneous fibrous histiocytoma 10.2

Graphical network of the top 20 diseases related to Parosteal Osteosarcoma:



Diseases related to Parosteal Osteosarcoma

Symptoms & Phenotypes for Parosteal Osteosarcoma

MGI Mouse Phenotypes related to Parosteal Osteosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.73 EWSR1 FRS2 GNAS MDM2 RECQL4 SATB2
2 neoplasm MP:0002006 9.72 CDK4 EWSR1 GNAS MDM2 RECQL4
3 endocrine/exocrine gland MP:0005379 9.7 CDK4 EWSR1 GNAS MDM2 RBM4B RECQL4
4 embryo MP:0005380 9.5 CDK4 COPS3 FRS2 GNAS MDM2 RECQL4
5 craniofacial MP:0005382 9.1 CDK4 FRS2 GNAS MDM2 RECQL4 SATB2

Drugs & Therapeutics for Parosteal Osteosarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Parosteal OsTeosarcoma: a Single Istitution Experience Completed NCT03768076
2 Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas (COSS-Registry) Not yet recruiting NCT05515068

Search NIH Clinical Center for Parosteal Osteosarcoma

Cochrane evidence based reviews: osteosarcoma, juxtacortical

Genetic Tests for Parosteal Osteosarcoma

Anatomical Context for Parosteal Osteosarcoma

Organs/tissues related to Parosteal Osteosarcoma:

MalaCards : Bone, Lung, Liver

Publications for Parosteal Osteosarcoma

Articles related to Parosteal Osteosarcoma:

(show top 50) (show all 376)
# Title Authors PMID Year
1
Dedifferentiation in low-grade osteosarcoma: a Japanese Musculoskeletal Oncology Group (JMOG) study. 62
35932377 2022
2
Zygomatic arch reconstruction with a patient-specific polycaprolactone/beta-tricalcium phosphate scaffold after parosteal osteosarcoma resection in a dog. 62
36168884 2022
3
Does the adherence of distal femur parosteal osteosarcoma to the neurovascular bundle increase the rate of local recurrences? 62
35093566 2022
4
Differential Retrospective Analysis in Oral Cancerous, Pre-cancerous, and Benign Tissue Biopsies. 62
35572462 2022
5
Sarcomas of fat and bone: a case report. 62
35384584 2022
6
Parosteal osteosarcoma of the thumb: A case report and literature review. 62
35091042 2022
7
Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) of the Foot: A Case Report and Literature Review of Nora's Lesion of the Foot. 62
35602798 2022
8
Parosteal osteosarcoma with high-grade transformation and lung metastasis after 12 years: a rare presentation. 62
34898877 2022
9
JUXTACORTICAL OSTEOSARCOMA: CLINICAL EVOLUTION AND DEDIFFERENTIATION RELATED FACTORS. 62
36451789 2022
10
Oncological and Functional Outcomes after Hemicortical Resection and Biological Reconstruction Using Allograft for Parosteal Osteosarcoma of the Distal Femur. 62
35692235 2022
11
Low-grade osteosarcoma is predominant in gnathic osteosarcomas: A report of seven cases of osteosarcoma of the jaw. 62
34008925 2021
12
Protuberant fibro-osseous lesion of the temporal bone: report of four cases and review of the literature. 62
33865660 2021
13
Allograft reconstruction for large parosteal osteoma of the clavicle: a case report. 62
34823310 2021
14
A Rare Occurrence of Multiple Intracranial Osteomas in the Cranial Cavity of a Cadaver With a Short Review on Subdural Osteoma. 62
34659951 2021
15
Parosteal osteosarcoma with a manifestation of subperiosteal low-grade central osteosarcoma. 62
33704522 2021
16
Surface osteosarcoma: Predictors of outcomes. 62
34043244 2021
17
Two cases of parosteal osteosarcoma with unusual histological and molecular features. 62
33272695 2021
18
Parosteal osteosarcoma of the mandible in a pediatric patient. 62
33579634 2021
19
Dedifferentiated Osteosarcoma of the Distal Ulna: A Case Report. 62
34703440 2021
20
Parosteal Osteosarcoma with Pancreatic Metastasis and Multiple Relapses: A Case Report and Review of the Literature. 62
34188664 2021
21
Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion) in Pediatric Phalanges. 62
32611484 2021
22
Computer-assisted surgical planning of complex bone tumor resections improves negative margin outcomes in a sawbones model. 62
33725339 2021
23
Costal Osteoma: Report of a Case in an Unusual Site. 62
33864678 2021
24
The value of chest and skeletal staging in parosteal osteosarcoma: two-centre experience and literature review. 62
32705301 2021
25
Parosteal osteosarcoma associated with a low-grade component mimicking well-differentiated liposarcoma: a case report. 62
32564106 2021
26
Case Report: Metastatic Parosteal Osteosarcoma in a Dog. 62
34504888 2021
27
Was it Ewing's? A Diagnostic and Therapeutic Dilemma. 62
33364700 2020
28
Rapidly growing Fibro-osseous pseudotumor of the digit: A case report. 62
32664136 2020
29
Parosteal Osteosarcoma of the Proximal Phalanx of a Finger. 62
31537402 2020
30
Low-grade Osteosarcomatous Dedifferentiation of an Atypical Lipomatous Tumor in a Pediatric Patient. 62
31739757 2020
31
[Parosteal low-grade osteosarcoma with focal differentiation]. 62
31919554 2020
32
[Osteoid-forming bone tumors : Morphology and current translational cell biology]. 62
32078700 2020
33
Inflammation and infiltration: can the radiologist draw a line? MRI versus CT to accurately assess medullary involvement in parosteal osteosarcoma. 62
32079463 2020
34
Parosteal Osteosarcoma: A Benign-Looking Tumour, Amenable to a Variety of Surgical Reconstruction. 62
32550023 2020
35
Nail Salon a Potential Source of a Rare Mycobacterium Fortuitum Infection In Proximal Tibia Megaprosthesis? A Case Report. 62
32566452 2020
36
Gene amplification and tumor grading in parosteal osteosarcoma. 62
31634336 2019
37
Parosteal osteosarcoma: a monocentric retrospective analysis of 195 patients. 62
31128127 2019
38
Zygomatic Arch Parosteal Osteosarcoma in Dogs and a Cat. 62
30244660 2019
39
Parosteal osteosarcoma with focal fatty metaplasia: A case report. 62
30425774 2019
40
Modular endoprosthetic implant for maximizing residual limb length: A case report. 62
30319024 2019
41
Parosteal osteosarcoma of the fibula in a middle-aged patient: A case report. 62
30633158 2019
42
A rare rib lesion due to parosteal osteosarcoma: a case report. 62
30670083 2019
43
Osteosarcoma in patients below 25 years of age: An observational study of incidence, metastasis, treatment and outcomes. 62
30405789 2018
44
Can imaging distinguish between low-grade and dedifferentiated parosteal osteosarcoma? 62
30190236 2018
45
Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis. 62
30001240 2018
46
Dedifferentiated parosteal osteosarcoma of the maxilla: a case report and review of the literature. 62
30115116 2018
47
Analysis of miR-148b expression differences in stage-I and II parosteal osteosarcoma. 62
29963175 2018
48
On the importance of considering disease subtypes: Earliest detection of a parosteal osteosarcoma? Differential diagnosis of an osteosarcoma in an Anglo-Saxon female. 62
29776880 2018
49
Unsintered Hydroxyapatite and Poly-L-Lactide Composite Screws/Plates for Stabilizing β-Tricalcium Phosphate Bone Implants. 62
29854351 2018
50
[Dedifferentiated diaphyseal juxtacortical osteosarcoma of ulna with metastasis to the lung]. 62
30521709 2018

Variations for Parosteal Osteosarcoma

Expression for Parosteal Osteosarcoma

Search GEO for disease gene expression data for Parosteal Osteosarcoma.

Pathways for Parosteal Osteosarcoma

Pathways related to Parosteal Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.9 MDM2 CDK4
2 10.76 MDM2 CDK4
3 10.54 MDM2 CDK4
4 10.14 MDM2 CDK4

GO Terms for Parosteal Osteosarcoma

Sources for Parosteal Osteosarcoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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