MCID: PRT031
MIFTS: 27

Parotid Disease

Categories: Oral diseases

Aliases & Classifications for Parotid Disease

MalaCards integrated aliases for Parotid Disease:

Name: Parotid Disease 12 15
Parotid Diseases 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10302
MeSH 44 D010305
UMLS 73 C0030579

Summaries for Parotid Disease

MalaCards based summary : Parotid Disease, also known as parotid diseases, is related to parotitis and suppurative otitis media. An important gene associated with Parotid Disease is CD40LG (CD40 Ligand), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Vaccines and Heptavalent Pneumococcal Conjugate Vaccine have been mentioned in the context of this disorder.

Related Diseases for Parotid Disease

Diseases related to Parotid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 parotitis 10.8
2 suppurative otitis media 10.6 CD40LG HSF4
3 spinal cord disease 10.6 CD40LG HSF4
4 herpetic whitlow 10.5 CD40LG PGRMC1
5 mononeuritis multiplex 10.4 CD40LG CDSN
6 mononeuritis of upper limb and mononeuritis multiplex 10.4 CD40LG CDSN
7 mononeuropathy 10.4 CD40LG CDSN
8 selective igg deficiency disease 10.2 CD40LG CD79A
9 c1q nephropathy 10.2 CD40LG CD79A
10 meningovascular neurosyphilis 10.2 CD40LG CD79A
11 alpha chain disease 10.2 CD40LG CD79A
12 brill-zinsser disease 10.2 CD40LG CD79A
13 exudative glomerulonephritis 10.2 CD40LG CD79A
14 cork-handlers' disease 10.2 CD40LG CD79A
15 salpingo-oophoritis 10.2 CD40LG CD79A
16 early yaws 10.2 CD40LG CD79A
17 ventilation pneumonitis 10.2 CD40LG CD79A
18 axillary adenitis 10.2 CD40LG CD79A
19 cryofibrinogenemia 10.2 CD40LG CD79A
20 trichostrongyloidiasis 10.2 CD40LG CD79A
21 subacute bacterial endocarditis 10.2 CD40LG CD79A
22 heterophyiasis 10.2 CD40LG CD79A
23 immunoglobulin g deficiency 10.2 CD40LG CD79A
24 orbital granuloma 10.2 CD40LG CD79A
25 transient hypogammaglobulinemia of infancy 10.2 CD40LG CD79A
26 hyperglobulinemic purpura 10.2 CD40LG CD79A
27 gastroduodenitis 10.2 CD40LG CD79A
28 bacterial conjunctivitis 10.2 CD40LG CD79A
29 heavy chain disease 10.2 CD40LG CD79A
30 ophthalmia neonatorum 10.2 CD40LG CD79A
31 immunoglobulin a deficiency 1 10.2 CD40LG CD79A
32 cerebral arteritis 10.2 CD40LG CD79A
33 selective immunoglobulin deficiency disease 10.2 CD40LG CD79A
34 geniculate herpes zoster 10.2 CD40LG CD79A
35 erythema elevatum diutinum 10.2 CD40LG CD79A
36 sporotrichosis 10.2 CD40LG CD79A
37 fallopian tube disease 10.2 CD40LG CD79A
38 hyperimmunoglobulin syndrome 10.2 CD40LG CD79A
39 congenital syphilis 10.2 CD40LG CD79A
40 polyclonal hypergammaglobulinemia 10.2 CD40LG CD79A
41 monoclonal paraproteinemia 10.2 CD40LG CD79A
42 salpingitis 10.2 CD40LG CD79A
43 ocular toxoplasmosis 10.2 CD40LG CD79A
44 dysgammaglobulinemia 10.2 CD40LG CD79A
45 congenital hypogammaglobulinemia 10.1 CD40LG CD79A
46 acute maxillary sinusitis 10.1 CD40LG CD79A
47 chronic polyneuropathy 10.1 CD40LG CD79A
48 spinocerebellar ataxia, autosomal recessive 10 10.1 CD40LG CD79A
49 parasitic ichthyosporea infectious disease 10.1 CD40LG CD79A
50 cd40 ligand deficiency 10.1 CD40LG CD79A

Graphical network of the top 20 diseases related to Parotid Disease:



Diseases related to Parotid Disease

Symptoms & Phenotypes for Parotid Disease

Drugs & Therapeutics for Parotid Disease

Drugs for Parotid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
2 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
3
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
4
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
5
Bevacizumab Approved, Investigational Phase 1 216974-75-3
6
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
7 Angiogenesis Inhibitors Phase 1
8 Angiogenesis Modulating Agents Phase 1
9 Protein Kinase Inhibitors Phase 1
10 Antimitotic Agents Phase 1
11
Menthol Approved Not Applicable 2216-51-5 16666
12
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
13
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
14 Antibodies
15 Immunoglobulins
16 Chelating Agents Not Applicable
17 Anticoagulants Not Applicable
18 Calcium, Dietary Not Applicable
19 Analgesics Not Applicable
20 Central Nervous System Depressants Not Applicable
21 Narcotics Not Applicable
22 Analgesics, Opioid Not Applicable
23 Peripheral Nervous System Agents Not Applicable
24 Citrate Nutraceutical Not Applicable

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Completed NCT02880865 Phase 4
2 Comparative Study of the Immunogenicity of MMR (Measles, Mumps and Rubella) Single Dose and Multidose Presentations Completed NCT01777529 Phase 4
3 Immunogenicity and Safety of Hepatitis A Vaccine Given at the Same Time of Measles, Mumps, Rubella Combined Vaccine Completed NCT00313950 Phase 4
4 Immunogenicity and Safety of Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00126997 Phase 4
5 Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors Unknown status NCT01216800 Phase 3
6 Safety and Immunogenicity Study of Live Attenuated Mumps Vaccines in Healthy Infants Completed NCT02692599 Phase 3
7 Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age Completed NCT02184572 Phase 3
8 Immunogenicity and Safety of GSK Biologicals' Combined Measles-mumps-rubella Vaccine in Volunteers, Seven Years of Age and Older Completed NCT02058563 Phase 3
9 Study of Immunogenicity, Reactogenicity and Safety of the Combined Measles, Mumps and Rubella Vaccine Produced by Bio-Manguinhos/Fiocruz in Children 12-15 Months of Age, Followed by Tetraviral Vaccine in Children 15-18 Months. Completed NCT01991899 Phase 3
10 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life Completed NCT01681992 Phase 3
11 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Subjects Four to Six Years of Age Completed NCT01621802 Phase 3
12 Safety, Tolerability, and Immunogenicity of Measles, Mumps, Rubella, and Varicella (MMRV) Vaccine Made With an Alternative Manufacturing Process (AMP)(V221-027) Completed NCT01536405 Phase 3
13 The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's Syndrome Completed NCT01414790 Phase 3
14 Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers Completed NCT01188343 Phase 3
15 Comparison of GSK Measles-mumps-rubella-varicella (MMRV) Vaccine Versus PriorixTM Completed NCT00969436 Phase 3
16 Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136 Completed NCT00751348 Phase 3
17 Long-term Follow-up on Immunogenicity & Safety of Measles-Mumps-Rubella-Varicella (MMRV) Combined Vaccine Completed NCT00406211 Phase 3
18 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127023 Phase 3
19 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127010 Phase 3
20 Study to Evaluate Frozen Versus Refrigerated MMRV (Combined Measles, Mumps, Rubella, and Varicella) Investigational Vaccine (V221-016) Completed NCT00092430 Phase 3
21 A Study of An Approved Vaccine at Mumps Expiry Potency in Healthy Children 12 to 18 Months of Age (V205C-007)(COMPLETED) Completed NCT00092391 Phase 3
22 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00353288 Phase 2
23 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00352898 Phase 2
24 Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Active, not recruiting NCT03133923 Phase 2
25 A Phase I, Safety Study of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Children Completed NCT01712906 Phase 1
26 Phase I of Biologics and Chemoradiation Therapy for Advanced Head and Neck Cancer Completed NCT00405405 Phase 1 Cisplatin;Docetaxel;Bevacizumab;Erlotinib
27 Diagnostic Accuracy of Fine Needle Aspiration in Parotid Tumors Unknown status NCT00534612 Early Phase 1
28 Evaluation of Safety and Effectiveness of the FMwand Ferromagnetic Surgical System During Parotidectomy Surgery Completed NCT02291939
29 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226 Not Applicable
30 Retrospective Clinical Outcome of Parotid Tumor Surgery Completed NCT01983176
31 Serological Study in Children 12 to 23 Months Vaccinated With MMR (Measles, Mumps and Rubella) Completed NCT01874457
32 Making Decisions About the Measles-Mumps-Rubella Vaccine Completed NCT01369394 Not Applicable
33 Measles, Mumps, and Rubella (MMR) Immunity in College Students Completed NCT00962819
34 Feasibility Study of MRI Imaging on Parotid Gland Stimulation Active, not recruiting NCT02294838 Not Applicable
35 Gender and Opioid Consumption Not yet recruiting NCT03006627 Not Applicable postoperative morphine
36 Safety Study of Measles-Mumps-Rubella-Varicella (MMRV) Vaccine, Priorix-Tetra™ in Children Living in the Philippines Withdrawn NCT01738841

Search NIH Clinical Center for Parotid Disease

Cochrane evidence based reviews: parotid diseases

Genetic Tests for Parotid Disease

Anatomical Context for Parotid Disease

Publications for Parotid Disease

Articles related to Parotid Disease:

(show all 25)
# Title Authors Year
1
Quality of life following surgical treatment of benign parotid disease. ( 24427625 )
2013
2
The diagnosis and management of parotid disease. ( 23159219 )
2013
3
Evaluation of superficial musculoaponeurotic system flap and fat graft outcomes for benign and malignant parotid disease. ( 23358951 )
2013
4
Polycystic parotid disease in a male child: report of a case and review of the literature. ( 21256652 )
2011
5
Predictors of facial palsy after surgery for benign parotid disease: multivariate analysis of 626 operations. ( 19536764 )
2009
6
Analysis of complications following surgical treatment of benign parotid disease. ( 18269474 )
2008
7
Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. ( 16585855 )
2006
8
Extent of parotid disease influences outcome in patients with metastatic cutaneous squamous cell carcinoma. ( 12874077 )
2003
9
The role of imaging in the evaluation of parotid disease. ( 12169280 )
2002
10
Surgical management of parotid disease. ( 11709975 )
2000
11
Surgical management of chronic parotid disease. ( 11092780 )
2000
12
Surgical management of parotid disease. ( 11905347 )
1998
13
Periparotid lupus erythematosus panniculitis. Clinicopathologic correlation of two cases presenting as primary parotid disease. ( 8489346 )
1993
14
Surgical treatment in non-neoplastic parotid disease: indications and results. ( 1393876 )
1992
15
Parotid disease and human immunodeficiency virus infection in Zambia. ( 1393467 )
1992
16
Polycystic parotid disease: a case report. ( 1941341 )
1991
17
Parotid disease associated with human immunodeficiency virus infection. ( 2401224 )
1990
18
Diagnostic techniques for parotid disease. ( 2945579 )
1986
19
A comparative analysis of the clinical, sialographic, and pathologic findings in parotid disease. ( 4062061 )
1985
20
Surgical parotid disease in Nigeria: a review of 100 cases. ( 6589340 )
1984
21
Diagnostic ultrasound imaging of parotid disease--a contemporary clinical perspective. ( 6471159 )
1984
22
Historical and pathological curiosities of parotid disease. ( 4665891 )
1972
23
Surgery and facial nerve grafting in malignant parotid disease. ( 4315450 )
1970
24
Surgery for nonneoplastic parotid disease. ( 5506056 )
1970
25
Surgical management of benign parotid disease. ( 5337252 )
1967

Variations for Parotid Disease

Expression for Parotid Disease

Search GEO for disease gene expression data for Parotid Disease.

Pathways for Parotid Disease

Pathways related to Parotid Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Parotid Disease

Biological processes related to Parotid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD40LG CD79A
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Parotid Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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