MCID: PRT031
MIFTS: 30

Parotid Disease

Categories: Oral diseases

Aliases & Classifications for Parotid Disease

MalaCards integrated aliases for Parotid Disease:

Name: Parotid Disease 12 15 17
Parotid Diseases 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10302
MeSH 43 D010305
UMLS 71 C0030579

Summaries for Parotid Disease

MalaCards based summary : Parotid Disease, also known as parotid diseases, is related to parotitis and sarcoidosis 1. An important gene associated with Parotid Disease is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include lymph node, salivary gland and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Parotid Disease

Diseases related to Parotid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 314)
# Related Disease Score Top Affiliating Genes
1 parotitis 31.0 TRIM21 SSB SPINK1 L3MBTL1 KLK4 CRP
2 sarcoidosis 1 29.9 CRP CD8A CD40LG CD4
3 sialadenitis 29.8 TRIM21 SSB CD8A CD4
4 facial paralysis 29.5 CRP CRLF1 CD8A CD40LG CD4
5 parotid gland cancer 28.9 ZNFX1 TNS4 L3MBTL1 ERBB2
6 intestinal tuberculosis 10.5 CRP CD4
7 japanese spotted fever 10.5 CRP CD40LG
8 chronic orbital inflammation 10.5 CRP CD40LG
9 splenic abscess 10.5 CRP CD40LG
10 ecthyma 10.5 CRP CD40LG
11 acalculous cholecystitis 10.5 CRP CD40LG
12 american histoplasmosis 10.5 CD40LG CD4
13 syphilitic meningitis 10.5 CD40LG CD4
14 asymptomatic neurosyphilis 10.5 CD40LG CD4
15 latent syphilis 10.5 CD40LG CD4
16 rheumatoid arthritis interstitial lung disease 10.5 CRP CD4
17 gastroduodenitis 10.5 CD40LG CD4
18 epiglottitis 10.5 CRP CD40LG
19 primary syphilis 10.5 CD40LG CD4
20 transient arthritis 10.5 CD40LG CD4
21 pericardial tuberculosis 10.5 CRP CD4
22 necrotizing ulcerative gingivitis 10.5 CD40LG CD4
23 viral laryngitis 10.5 CRP CD40LG
24 tertiary neurosyphilis 10.5 CD40LG CD4
25 klebsiella pneumonia 10.5 CRP CD40LG
26 bacillary angiomatosis 10.5 CD40LG CD4
27 pyomyositis 10.5 CRP CD4
28 subacute bacterial endocarditis 10.5 CRP CD40LG
29 cerebral lymphoma 10.5 CD40LG CD4
30 acute orbital inflammation 10.5 CRP CD4
31 hyperglobulinemic purpura 10.4 TRIM21 CD40LG
32 exanthema subitum 10.4 CD40LG CD4
33 nocardiosis 10.4 CRP CD4
34 ornithosis 10.4 CRP CD40LG
35 late congenital syphilis 10.4 CRP CD40LG
36 hematocele of tunica vaginalis testis 10.4 CRP CRLF1
37 autoimmune peripheral neuropathy 10.4 CD40LG CD4
38 congenital syphilis 10.4 CD40LG CD4
39 lymph node tuberculosis 10.4 L3MBTL1 CD4
40 trichinosis 10.4 CD40LG CD4
41 ventilation pneumonitis 10.4 CD8A CD4
42 glossopharyngeal nerve disease 10.4 CRP CRLF1
43 granulomatous dermatitis 10.4 CD40LG CD4
44 diabetes mellitus, insulin-dependent, 23 10.4 CD8A CD4
45 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
46 bacterial conjunctivitis 10.4 CRP CD40LG
47 chancroid 10.4 CD40LG CD4
48 parapsoriasis 10.4 CD8A CD4
49 splenic infarction 10.4 CRP CD40LG
50 granulomatous myositis 10.4 TRIM21 CD8A

Graphical network of the top 20 diseases related to Parotid Disease:



Diseases related to Parotid Disease

Symptoms & Phenotypes for Parotid Disease

MGI Mouse Phenotypes related to Parotid Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 CD4 CD40LG CD8A CRLF1 L3MBTL1 PSMB8
2 immune system MP:0005387 9.32 CD4 CD40LG CD8A CRP L3MBTL1 PSMB8

Drugs & Therapeutics for Parotid Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Safety and Effectiveness of the FMwand Ferromagnetic Surgical System During Parotidectomy Surgery Completed NCT02291939

Search NIH Clinical Center for Parotid Disease

Cochrane evidence based reviews: parotid diseases

Genetic Tests for Parotid Disease

Anatomical Context for Parotid Disease

MalaCards organs/tissues related to Parotid Disease:

40
Lymph Node, Salivary Gland, Bone, Breast, Skin

Publications for Parotid Disease

Articles related to Parotid Disease:

(show top 50) (show all 126)
# Title Authors PMID Year
1
Long-Term Results of a Pedicled and Innervated Sternocleidomastoid Muscle Flap to Immediately Reconstruct Superficial Parotidectomy Defects. 61
32456521 2020
2
Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy. 61
31291005 2020
3
Graft interposition for preventing Frey's syndrome in patients undergoing parotidectomy. 61
31578708 2019
4
Parotid incidentalomas on positron emission tomography: what is their clinical significance? 61
30614921 2019
5
The Clinical Significance of Incidental Parotid Uptake in a PET/CT Study: A Diagnostic Algorithm. 61
31989884 2019
6
Ultrasound detection of incidental diffuse parotid disease: A single-center study. 61
31269074 2019
7
Value of Visualization of the Intraparotid Facial Nerve and Parotid Duct Using a Micro Surface Coil and Three-Dimensional Reversed Fast Imaging With Steady-State Precession and Diffusion-Weighted Imaging Sequence. 61
29927823 2018
8
Buccal space malignancy in the setting of chronic sialadenitis: A report of 2 cases. 61
29493724 2018
9
Comparison of Complications in Parotid Surgery With Harmonic Scalpel Versus Cold Instruments. 61
28230591 2017
10
Thirty-Day Perioperative Outcomes in Pediatric Parotidectomy. 61
27254314 2016
11
Head and neck melanoma (excluding ocular melanoma): United Kingdom National Multidisciplinary Guidelines. 61
27841141 2016
12
Contrast-enhanced ultrasound in the evaluation of parotid gland lesions: an update of the literature. 61
27482279 2016
13
Oncocytic carcinoma of the major salivary glands: A population-based study of 278 cases. 61
26829582 2016
14
Rare Parotid Gland Diseases. 61
26902981 2016
15
Parotid Gland Imaging. 61
26902980 2016
16
Evaluation of Parotid Glands With Real-time Ultrasound Elastography in Children. 61
26903660 2016
17
Sensitivity, Specificity, and Posttest Probability of Parotid Fine-Needle Aspiration: A Systematic Review and Meta-analysis. 61
26428476 2016
18
Sinonasal and skull base pleomorphic adenoma: a case series and literature review. 61
25712714 2015
19
Idiopathic Chronic Parotitis: Imaging Findings and Sialendoscopic Response. 61
26376430 2015
20
A comparison of parotid imaging characteristics and sialendoscopic findings in obstructive salivary disorders. 61
24932900 2014
21
[The effect evaluation of suction drainage to prevent fistula after superficial parotidectomy]. 61
25636298 2014
22
Reconstructive techniques of the parotid region. 61
24705234 2014
23
Parotid abscess: a retrospective study of 14 cases at a regional hospital in Taiwan. 61
25654957 2014
24
High-frequency ultrasound in parotid gland disease. 61
24263755 2013
25
Quality of life following surgical treatment of benign parotid disease. 61
24427625 2013
26
Evaluation of superficial musculoaponeurotic system flap and fat graft outcomes for benign and malignant parotid disease. 61
23358951 2013
27
An algorithm approach to diagnosing bilateral parotid enlargement. 61
23380830 2013
28
The diagnosis and management of parotid disease. 61
23159219 2013
29
[Salivary stone in parotid gland with a cutaneous fistula]. 61
23305643 2013
30
Parotidectomy and neck dissection in the management of conjunctival melanoma: are they necessary? 61
23007927 2012
31
Wegener's granulomatosis of the major salivary glands. 61
22417113 2012
32
Parotid gland disease in childhood: diagnosis and indications for surgical intervention. 61
21715068 2012
33
Idiopathic masseter muscle hypertrophy. 61
22435002 2011
34
Primary Sjögren syndrome in a 2-year-old patient: role of the dentist in diagnosis and dental management with a 6-year follow-up. 61
21623979 2011
35
The extended indication of parotidectomy using the modified facelift incision in benign lesions: retrospective analysis of a single institution. 61
21858558 2011
36
Face-lift incision combined with sternomastoid muscular flap in parotidectomy. 61
21403992 2011
37
Comparison of facial nerve injury and recovery rates after antegrade and retrograde nerve dissection in parotid surgery for benign disease: prospective study over 4 years. 61
20554358 2011
38
Polycystic parotid disease in a male child: report of a case and review of the literature. 61
21256652 2011
39
Pathologic occult neck disease in patients with metastatic cutaneous squamous cell carcinoma to the parotid. 61
21493233 2011
40
Efficacy of conventional whole-body ¹⁸F-FDG PET/CT in the incidental findings of parotid masses. 61
20640540 2010
41
Predictors of facial palsy after surgery for benign parotid disease: multivariate analysis of 626 operations. 61
19536764 2009
42
Parotid incidentaloma identified by combined 18F-fluorodeoxyglucose whole-body positron emission tomography and computed tomography: findings at grayscale and power Doppler ultrasonography and ultrasound-guided fine-needle aspiration biopsy or core-needle biopsy. 61
19396445 2009
43
Primary squamous cell carcinoma of Stensen's duct in a patient with HIV: the role of magnetic resonance imaging and fine-needle aspiration. 61
18642319 2009
44
Elective parotidectomy in the management of advanced auricular malignancies. 61
19029866 2008
45
[Macroamylasaemia in paediatrics]. 61
19128745 2008
46
Parotid surgery in patients over seventy-five years old. 61
19186451 2008
47
Preventing post-surgical complications by modification of parotidectomy. 61
18262762 2008
48
Quality of life after surgery for benign disease of the parotid gland. 61
17537273 2008
49
Analysis of complications following surgical treatment of benign parotid disease. 61
18269474 2008
50
Parotidectomy--a prospective study. 61
18705263 2008

Variations for Parotid Disease

Expression for Parotid Disease

Search GEO for disease gene expression data for Parotid Disease.

Pathways for Parotid Disease

Pathways related to Parotid Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 TRIM21 TNFRSF25 PSMB8 MUC1 ERBB2 CRP
2
Show member pathways
12.34 TRIM21 TNFRSF25 PSMB8 MUC1 ERBB2 CRLF1
3 12.07 TNFRSF25 PSMB8 CD8A CD40LG
4 10.71 CD8A CD40LG CD4

GO Terms for Parotid Disease

Cellular components related to Parotid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 TNFRSF25 SPINK1 MUC1 KLK4 CRP CRLF1

Biological processes related to Parotid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.5 ERBB2 CD8A CD4
2 cell surface receptor signaling pathway GO:0007166 9.46 TNFRSF25 ERBB2 CD8A CD4
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 TNFRSF25 PSMB8 CD40LG
4 positive regulation of viral entry into host cell GO:0046598 8.96 TRIM21 CD4
5 enzyme linked receptor protein signaling pathway GO:0007167 8.62 ERBB2 CD4

Molecular functions related to Parotid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.5 TRIM21 TNS4 TNFRSF25 SSB SPINK1 PSMB8

Sources for Parotid Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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