MCID: PRT009
MIFTS: 32

Parotid Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Parotid Gland Cancer

MalaCards integrated aliases for Parotid Gland Cancer:

Name: Parotid Gland Cancer 12 15
Parotid Neoplasms 44 70
Malignant Neoplasm of the Parotid 12
Malignant Tumor of Parotid Gland 12
Cancer of Parotid Gland 12
Parotid Gland Carcinoma 17
Cancer of Parotid 70
Parotid Neoplasm 17
Parotid Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9036
ICD9CM 34 142.0
MeSH 44 D010307
NCIt 50 C3525
SNOMED-CT 67 93949007
ICD10 32 C07
UMLS 70 C0030581 C0747273

Summaries for Parotid Gland Cancer

Disease Ontology : 12 A salivary gland cancer that is located in the parotid gland.

MalaCards based summary : Parotid Gland Cancer, also known as parotid neoplasms, is related to parotid disease and pleomorphic adenoma carcinoma. An important gene associated with Parotid Gland Cancer is BCYRN1 (Brain Cytoplasmic RNA 1). The drugs Pharmaceutical Solutions and Sodium citrate have been mentioned in the context of this disorder. Affiliated tissues include parotid gland, salivary gland and breast.

Related Diseases for Parotid Gland Cancer

Diseases related to Parotid Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 parotid disease 30.0 ZNFX1 TNS4 SLC26A9
2 pleomorphic adenoma carcinoma 29.7 TP53 ERBB2
3 parotid gland adenoid cystic carcinoma 11.2
4 salivary gland carcinoma 10.2
5 breast metaplastic carcinoma 10.2 ERBB2 BCYRN1
6 pleomorphic adenoma 10.1
7 adenoid cystic carcinoma 10.1
8 warthin tumor 10.1
9 gastric papillary adenocarcinoma 10.0 TP53 ERBB2
10 papillary adenocarcinoma 10.0 TP53 ERBB2
11 apocrine adenosis of breast 10.0 TP53 ERBB2
12 comedo carcinoma 10.0 TP53 ERBB2
13 breast sarcoma 10.0 TP53 ERBB2
14 breast malignant phyllodes tumor 10.0 TP53 ERBB2
15 esophageal adenosquamous carcinoma 10.0 TP53 ERBB2
16 localized osteosarcoma 10.0 TP53 ERBB2
17 ovarian carcinosarcoma 10.0 TP53 ERBB2
18 primary peritoneal carcinoma 10.0 TP53 ERBB2
19 granulosa cell tumor of the ovary 10.0 TP53 ERBB2
20 synchronous bilateral breast carcinoma 10.0 TP53 ERBB2
21 large intestine adenocarcinoma 10.0 TP53 ERBB2
22 facial paralysis 10.0
23 microglandular adenosis 10.0 TP53 ERBB2
24 vulvar disease 10.0 TP53 ERBB2
25 endometrial serous adenocarcinoma 10.0 TP53 ERBB2
26 hypertrophy of breast 10.0 TP53 ERBB2
27 female reproductive endometrioid cancer 10.0 TP53 ERBB2
28 mature teratoma 10.0 TP53 ERBB2
29 adenosarcoma 10.0 TP53 ERBB2
30 uterine body mixed cancer 10.0 TP53 ERBB2
31 sebaceous adenocarcinoma 10.0 TP53 ERBB2
32 endocervical carcinoma 10.0 TP53 ERBB2
33 submandibular gland cancer 10.0 VPS4B ERBB2
34 lobular neoplasia 10.0 TP53 ERBB2
35 sweat gland cancer 10.0 TP53 ERBB2
36 sweat gland disease 10.0 TP53 ERBB2
37 thoracic benign neoplasm 10.0 TP53 ERBB2
38 breast benign neoplasm 10.0 TP53 ERBB2
39 mixed cell type cancer 10.0 TP53 ERBB2
40 signet ring cell adenocarcinoma 10.0 TP53 ERBB2
41 otitis media 10.0
42 suppurative otitis media 10.0
43 chronic purulent otitis media 10.0
44 paroxysmal hemicrania 10.0
45 gallbladder adenocarcinoma 9.9 TP53 ERBB2
46 mucositis 9.9
47 telangiectasis 9.9
48 acinar cell carcinoma 9.9
49 mucoepidermoid carcinoma 9.9
50 adenoma 9.9

Comorbidity relations with Parotid Gland Cancer via Phenotypic Disease Network (PDN):


Facial Paralysis

Graphical network of the top 20 diseases related to Parotid Gland Cancer:



Diseases related to Parotid Gland Cancer

Symptoms & Phenotypes for Parotid Gland Cancer

Drugs & Therapeutics for Parotid Gland Cancer

Drugs for Parotid Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 1, Phase 2
2
Sodium citrate Approved, Investigational 68-04-2
3
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
4 Anticoagulants
5 Chelating Agents
6 Citrate
7 Calcium, Dietary
8
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Multicenter Randomized Study of Cochlear Sparing Intensity Modulated Radiotherapy Versus Conventional Radiotherapy in Patients With Parotid Tumors Unknown status NCT01216800 Phase 3
2 The Use of Human Acellular Dermal Matrix in the Prevention of Infraauricular Depressed Deformities and Frey's Syndrome Following Total Parotidectomy Completed NCT01414790 Phase 3
3 Phase 1/2 Trial of ALM-488 in Patients Undergoing Head & Neck Surgery Recruiting NCT04420689 Phase 1, Phase 2 ALM-488
4 Feasibility Study of MRI Imaging on Parotid Gland Stimulation Unknown status NCT02294838
5 Accuracy of Fine Needle Aspiration Biopsy in the Pre-Operative Diagnosis of Malignancy in Patients With Parotid Gland Masses Unknown status NCT00534612 Early Phase 1
6 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226
7 Human Salivary Gland Disposition of Alda-341 in Patients Undergoing Salivary Gland Surgery Completed NCT04296266 Early Phase 1 Alda-341
8 Trident Landmark as a Safe and Easy Method for Facial Nerve Trunk Identification During Superficial Parotidectomy Completed NCT04803032
9 Retrospective Clinical Outcome of Parotid Tumor Surgery Completed NCT01983176
10 Accuracy of Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology in the Preoperative Work-Up of Parotid Gland Neoplasms Recruiting NCT03849482
11 Postoperative Facial Weakness in Parotidectomy for Deep Seated Parotid Tumor With or Without Intra-parotid Facial Nerve Imaging (3D Double-Echo Steady-State With Water Excitation MRI Imaging) Recruiting NCT03822728
12 Intra-parotid Facial Nerve by MRI Tractography: Clinical vs Radiologic Description in Parotid Tumors Recruiting NCT03950323
13 FArial NErf MRI in the Preoperative Assessment of PArotide Tumors Recruiting NCT04613349
14 Study of the Facial Nerve in MRI 3T in the Preoperative Assessment of Parotid Tumors Withdrawn NCT04104802

Search NIH Clinical Center for Parotid Gland Cancer

Cochrane evidence based reviews: parotid neoplasms

Genetic Tests for Parotid Gland Cancer

Anatomical Context for Parotid Gland Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Parotid Gland Cancer:

19
Parotid Gland

MalaCards organs/tissues related to Parotid Gland Cancer:

40
Salivary Gland, Breast, Ovary, Lymph Node, Eye, Tonsil, Heart

Publications for Parotid Gland Cancer

Articles related to Parotid Gland Cancer:

(show top 50) (show all 256)
# Title Authors PMID Year
1
Pericardial metastasis of parotid mucoepidermoid carcinoma diagnosed by pericardial biopsy. 61
33750609 2021
2
Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review. 61
33169420 2021
3
Partial parotidectomy via periauricular incision: Retrospective cohort study and comparative analysis to alternative incisional approaches. 61
33191533 2021
4
In response to letter to the editor regarding: Functional outcomes after extracapsular dissection with partial facial nerve dissection for small and large parotid neoplasms. 61
33714558 2021
5
Regarding to functional outcomes after extracapsular dissection with partial facial nerve dissection for small and large parotid neoplasms. 61
33610386 2021
6
Correction to: Pre-treatment MRI predictor of high-grade malignant parotid gland cancer. 61
33543408 2021
7
Clinical outcomes of bulky parotid gland cancers: need for self-examination and screening program for early diagnosis of parotid tumors. 61
33602169 2021
8
Pre-treatment MRI predictor of high-grade malignant parotid gland cancer. 61
33389599 2021
9
Controversies in the Workup and Surgical Management of Parotid Neoplasms. 61
32571148 2021
10
Functional outcomes after extracapsular dissection with partial facial nerve dissection for small and large parotid neoplasms. 61
33188987 2021
11
Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review. 61
33534212 2021
12
Can Magnetic Resonance Radiomics Analysis Discriminate Parotid Gland Tumors? A Pilot Study. 61
33153140 2020
13
Clinical-pathological prognostic factors and treatment failure patterns in T1-2 high-grade parotid gland cancer. 61
32629407 2020
14
Fluorescence navigation with indocyanine green for identification of intersegmental planes using a photodynamic eye camera. 61
33145054 2020
15
["Point line anterograde dissection" for the safe preparation of supraclavicular flap]. 61
32911887 2020
16
Surgical extent and role of adjuvant radiotherapy of surgically resectable, low-grade parotid cancer. 61
32442895 2020
17
[Diagnostic value of high-resolution ultrasonography in parotid space occupying lesions]. 61
32791640 2020
18
Parotid adenocarcinoma metastasis to the breast: a case report. 61
32665831 2020
19
Pure abscopal effect of radiotherapy in a salivary gland carcinoma: Case report, literature review, and a search for new approaches. 61
32192840 2020
20
A meta-analysis of the pros and cons of partial superficial parotidectomy versus superficial parotidectomy for the treatment of benign parotid neoplasms. 61
32362539 2020
21
Intraparotid and cervical lymph nodes metastasis in primary parotid gland carcinoma-impact on clinical outcome. 61
32327323 2020
22
Perfusion Computed Tomography Scan Imaging in Differentiation of Benign from Malignant Parotid Lesions. 61
32256836 2020
23
Fine needle aspiration cytology for parotid neoplasms: risk of malignancy through inconclusive results and lower grade tumors. 61
31745630 2020
24
[Parotid CT imaging reporting and data system: A preliminary study]. 61
32071468 2020
25
Subcutaneous Injection of Hyaluronic Acid to Decrease Acute Skin Toxicity After Adjuvant Interstitial Brachytherapy in Parotid Gland Cancer Patients: A Nonrandomized Controlled Trial. 61
31604061 2020
26
Surgery and radiation management for chondrosarcoma of the temporo-mandibular joint: A Vietnamese case report. 61
31869705 2020
27
Reconstructive trends and complications following parotidectomy: incidence and predictors in 11,057 cases. 61
31744535 2019
28
Significance of intraparotid node metastasis in predicting local control in primary parotid cancer. 61
30549298 2019
29
An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland. 61
31591950 2019
30
Proton Beam Therapy for Locally Recurrent Parotid Gland Cancer. 61
31741929 2019
31
Nodular fasciitis of the parotid gland engulfing the facial nerve: a conservative approach. 61
31630128 2019
32
Risk stratification of fine-needle aspiration cytology of parotid neoplasms based on the Milan system-Experience from a tertiary center in Asia. 61
31131938 2019
33
Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging for Differentiation Between Parotid Neoplasms. 61
30922790 2019
34
Clinical application of supraclavicular flap for head and neck reconstruction. 61
31139924 2019
35
Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer. 61
30905082 2019
36
Parotidectomy-related facial nerve lesions: proposal for a modified Sunnybrook Facial Grading System. 61
31365637 2019
37
Dynamic Contrast-Enhanced MRI to Differentiate Parotid Neoplasms Using Golden-Angle Radial Sparse Parallel Imaging. 61
31048300 2019
38
Necrotizing sialometaplasia can hide the presence of salivary gland tumors: A case series. 61
30776173 2019
39
Clinical outcomes and management of facial nerve in patients with parotid gland cancer and pretreatment facial weakness. 61
30732953 2019
40
Epithelioid hemangioendothelioma of the parotid gland: a case report. 61
31149545 2019
41
Alpha-synuclein aggregates in the parotid gland of idiopathic REM sleep behavior disorder. 61
30195197 2018
42
Health effects from exposure to dental diagnostic X-ray. 61
30661338 2018
43
Preoperative diagnostic of parotid gland neoplasms: fine-needle aspiration cytology or core needle biopsy? 61
30238310 2018
44
Nodular fasciitis of the parotid gland: A challenging diagnosis on FNA. 61
30311731 2018
45
Increased incidence of Warthin tumours of the parotid gland: a 42-year evaluation. 61
30121841 2018
46
Evaluation of postoperative complications in elderly patients submitted to parotidectomy. 61
30183801 2018
47
Spectral multi-energy CT texture analysis with machine learning for tissue classification: an investigation using classification of benign parotid tumours as a testing paradigm. 61
29294157 2018
48
Comparing the RTOG/EORTC and LENT-SOMA scoring systems for the evaluation of late skin toxicity after 125I seed brachytherapy for parotid gland cancer. 61
29406124 2018
49
Anti-interferon-γ autoantibody-associated disseminated Mycobacterium abscessus infection mimicking parotid cancer with multiple metastases: A case report. 61
28953638 2017
50
Comparing the RTOG/EORTC and LENT-SOMA scoring systems for the evaluation of late skin toxicity after 125I seed brachytherapy for parotid gland cancer. 61
28495444 2017

Variations for Parotid Gland Cancer

Expression for Parotid Gland Cancer

Search GEO for disease gene expression data for Parotid Gland Cancer.

Pathways for Parotid Gland Cancer

GO Terms for Parotid Gland Cancer

Sources for Parotid Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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