MCID: PRT009
MIFTS: 35

Parotid Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Parotid Gland Cancer

MalaCards integrated aliases for Parotid Gland Cancer:

Name: Parotid Gland Cancer 12 15
Parotid Neoplasms 45 74
Malignant Neoplasm of the Parotid 12
Malignant Tumor of Parotid Gland 12
Cancer of Parotid Gland 12
Parotid Gland Carcinoma 17
Cancer of Parotid 74
Parotid Neoplasm 17
Parotid Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9036
ICD9CM 36 142.0
MeSH 45 D010307
NCIt 51 C3525
SNOMED-CT 69 93949007
ICD10 34 C07

Summaries for Parotid Gland Cancer

Disease Ontology : 12 A salivary gland cancer that is located in the parotid gland.

MalaCards based summary : Parotid Gland Cancer, also known as parotid neoplasms, is related to parotid gland adenoid cystic carcinoma and adenoma. An important gene associated with Parotid Gland Cancer is BCYRN1 (Brain Cytoplasmic RNA 1). The drugs Pembrolizumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, prostate and skin, and related phenotypes are Increased Nanog expression and Increased Nanog expression

Related Diseases for Parotid Gland Cancer

Diseases related to Parotid Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 parotid gland adenoid cystic carcinoma 11.2
2 adenoma 10.0
3 adenocarcinoma 9.9
4 pleomorphic adenoma 9.9
5 acute lymphocytic leukemia 9.9
6 leukemia 9.9
7 lymphocytic leukemia 9.9
8 pleomorphic adenoma carcinoma 9.9
9 paroxysmal hemicrania 9.9
10 pilomatrixoma 9.8
11 hyperhidrosis, gustatory 9.8
12 prostate cancer 9.8
13 hemangiopericytoma, malignant 9.8
14 oncocytoma 9.8
15 prostate cancer, hereditary, 8 9.8
16 prostate cancer, hereditary, 6 9.8
17 paraganglioma 9.8
18 lymphangioma 9.8
19 facial paralysis 9.7
20 actinomycosis 9.7
21 mycobacterium abscessus 9.7

Comorbidity relations with Parotid Gland Cancer via Phenotypic Disease Network (PDN):


Facial Paralysis

Graphical network of the top 20 diseases related to Parotid Gland Cancer:



Diseases related to Parotid Gland Cancer

Symptoms & Phenotypes for Parotid Gland Cancer

GenomeRNAi Phenotypes related to Parotid Gland Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.1 NUP62 ZIC3
2 Increased Nanog expression GR00371-A-2 9.1 NUP62 ZIC3
3 Increased Nanog expression GR00371-A-3 9.1 NUP62
4 Increased Nanog expression GR00371-A-5 9.1 ZIC3

Drugs & Therapeutics for Parotid Gland Cancer

Drugs for Parotid Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2 Antineoplastic Agents, Immunological Phase 2,Phase 1
3
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
4
Bevacizumab Approved, Investigational Phase 1 216974-75-3
5
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
6 Antimitotic Agents Phase 1
7 Angiogenesis Modulating Agents Phase 1
8 Angiogenesis Inhibitors Phase 1
9
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
10 Protein Kinase Inhibitors Phase 1
11
Sodium Citrate Approved, Investigational Not Applicable 68-04-2
12
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
13
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
14 Calcium, Dietary Not Applicable
15 Anticoagulants Not Applicable
16 Chelating Agents Not Applicable
17 Citrate Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors Unknown status NCT01216800 Phase 3
2 The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's Syndrome Completed NCT01414790 Phase 3
3 Quadrant Versus Superficial Parotidectomy Withdrawn NCT01607866 Phase 2, Phase 3
4 Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158) Recruiting NCT02628067 Phase 2
5 Phase I of Biologics and Chemoradiation Therapy for Advanced Head and Neck Cancer Completed NCT00405405 Phase 1 Cisplatin;Docetaxel;Bevacizumab;Erlotinib
6 Diagnostic Accuracy of Fine Needle Aspiration in Parotid Tumors Unknown status NCT00534612 Early Phase 1
7 Feasibility Study of MRI Imaging on Parotid Gland Stimulation Unknown status NCT02294838 Not Applicable
8 Optical Detection of Peripheral Nerve Bundles During Surgery Completed NCT01731379
9 Retrospective Clinical Outcome of Parotid Tumor Surgery Completed NCT01983176
10 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226 Not Applicable
11 Complications in Parotid Surgery Completed NCT02486393
12 Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology for Parotid Gland Neoplasms Recruiting NCT03849482
13 Intra-parotid Facial Nerve Imaging in Parotidectomy Recruiting NCT03822728 Not Applicable
14 Intra-parotid Facial Nerve Tractography Not yet recruiting NCT03950323 Not Applicable

Search NIH Clinical Center for Parotid Gland Cancer

Cochrane evidence based reviews: parotid neoplasms

Genetic Tests for Parotid Gland Cancer

Anatomical Context for Parotid Gland Cancer

MalaCards organs/tissues related to Parotid Gland Cancer:

42
Salivary Gland, Prostate, Skin, Lymph Node, Colon

The Foundational Model of Anatomy Ontology organs/tissues related to Parotid Gland Cancer:

20
The Parotid Gl

Publications for Parotid Gland Cancer

Articles related to Parotid Gland Cancer:

(show top 50) (show all 61)
# Title Authors Year
1
Clinical outcomes and management of facial nerve in patients with parotid gland cancer and pretreatment facial weakness. ( 30732953 )
2019
2
Dynamic Contrast-Enhanced MRI to Differentiate Parotid Neoplasms Using Golden-Angle Radial Sparse Parallel Imaging. ( 31048300 )
2019
3
Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging for Differentiation Between Parotid Neoplasms. ( 30922790 )
2019
4
Comparing the RTOG/EORTC and LENT-SOMA scoring systems for the evaluation of late skin toxicity after 125I seed brachytherapy for parotid gland cancer. ( 29406124 )
2018
5
Prediction of outcome by lymph node ratio in patients with parotid gland cancer. ( 27185037 )
2017
6
Prognostic relevance of epithelial-mesenchymal transition and proliferation in surgically treated primary parotid gland cancer. ( 27729431 )
2017
7
Comparing the RTOG/EORTC and LENT-SOMA scoring systems for the evaluation of late skin toxicity after 125I seed brachytherapy for parotid gland cancer. ( 28495444 )
2017
8
Exploratory study of long-term health-related quality of life in patients with surgically treated primary parotid gland cancer. ( 25223976 )
2016
9
Surgery for Primary Malignant Parotid Neoplasms. ( 27093700 )
2016
10
The incidence of radioepidermitis and the dose-response relationship in parotid gland cancer patients treated with 125I seed brachytherapy: incidence of radioepidermitis and the dose-response relationship. ( 25200358 )
2015
11
Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity. ( 26053092 )
2015
12
Prognostic Factors and Treatment Outcomes of Parotid Gland Cancer: A 10-Year Single-Center Experience. ( 26203086 )
2015
13
Facial nerve reconstruction following radical parotidectomy and subtotal petrosectomy for advanced malignant parotid neoplasms. ( 26981471 )
2015
14
Re: Use of fine-needle aspiration cytology in the diagnosis of parotid neoplasms. ( 26498567 )
2015
15
Retrospective Assessment of the Utility of Imaging, Fine-Needle Aspiration Biopsy, and Intraoperative Frozen Section in the Management of Parotid Neoplasms: The Weill Cornell Medical College Experience. ( 26159894 )
2015
16
Incidental Parotid Neoplasms: Pathology and Prevalence. ( 26019135 )
2015
17
Paediatric parotid neoplasms: a 10 year retrospective imaging and pathology review of these rare tumours. ( 25515793 )
2015
18
Diagnostic investigation of parotid neoplasms: a 16-year experience of freehand fine needle aspiration cytology and ultrasound-guided core needle biopsy. ( 25457828 )
2015
19
Use of fine-needle aspiration cytology in the diagnosis of parotid neoplasms. ( 25424665 )
2015
20
Diagnostic value of CT perfusion imaging for parotid neoplasms. ( 24186883 )
2014
21
Robotically assisted selective neck dissection in parotid gland cancer: preliminary report. ( 23208780 )
2013
22
Occurrence of lymph node metastasis in early-stage parotid gland cancer. ( 21671057 )
2012
23
Prognostic value of proliferating cell nuclear antigen in parotid gland cancer. ( 21874325 )
2012
24
Preliminary results of (125)I interstitial brachytherapy for locally recurrent parotid gland cancer in previously irradiated patients. ( 22488812 )
2012
25
Sonoelastography techniques in the evaluation and diagnosis of parotid neoplasms. ( 22367472 )
2012
26
Prognostic value of survivin expression in parotid gland cancer in consideration of different histological subtypes. ( 21397494 )
2011
27
An overview of the rare parotid gland cancer. ( 21917153 )
2011
28
Discrimination of parotid neoplasms from the normal parotid gland by use of Raman spectroscopy and support vector machine. ( 21439894 )
2011
29
Synchronous unilateral parotid neoplasms. A case report. ( 19179956 )
2009
30
Parotid neoplasms: analysis of 600 patients attended at a single institution. ( 19784416 )
2009
31
Gastrointestinal: isolated colonic metastasis from parotid gland cancer. ( 18699984 )
2008
32
An ileal metastasis from a parotid gland cancer that mimicked a flat adenoma. ( 17285507 )
2007
33
Massive deep lobe parotid neoplasms and parapharyngeal space-occupying lesions: contemporary diagnostics and surgical approaches. ( 17921922 )
2007
34
Preoperative cytology in the management of parotid neoplasms. ( 16500471 )
2006
35
Integrin receptors and extracellular matrix components in parotid neoplasms. ( 15812349 )
2005
36
Use of cross-sectional imaging in predicting surgical location of parotid neoplasms. ( 15891497 )
2005
37
Genetic expression profiling of parotid neoplasms by cDNA microarrays. ( 16450770 )
2005
38
Parotid gland cancer: a case report of a primitive adenocarcinoma arising from a multirecurrent pleomorphic adenoma. ( 15149165 )
2004
39
We present our experience employing magnetic resonance imaging (MRI) for the preoperative assessment of the patients with parotid gland cancer. ( 15366759 )
2004
40
Use of cross-sectional imaging in predicting facial nerve sacrifice during surgery for parotid neoplasms. ( 15583440 )
2004
41
Patients' perspectives on the short- and long-term outcomes following surgery for benign parotid neoplasms. ( 12956917 )
2003
42
Parotid neoplasms in children: experience of diagnosis and management in a district general hospital. ( 14505619 )
2003
43
Parotid neoplasms: diagnosis, treatment, and intraparotid facial nerve anatomy. ( 12080993 )
2002
44
Synchronous occurrence of 2 histologically distinct parotid neoplasms. ( 10847294 )
2000
45
Synchronous unilateral parotid neoplasms of different histological types. ( 10383249 )
1999
46
PSA immunoreactivity in a parotid oncocytoma: a diagnostic pitfall in discriminating primary parotid neoplasms from metastatic prostate cancer. ( 9741000 )
1998
47
Society of Surgical Oncology Practice Guidelines. Parotid gland cancer surgical practice guidelines. ( 9268982 )
1997
48
Bilateral parotid neoplasms. ( 7822187 )
1994
49
Subtotal petrosectomy in the management of advanced parotid neoplasms. ( 8464641 )
1993
50
Prognostic variables in parotid gland cancer. ( 1747227 )
1991

Variations for Parotid Gland Cancer

Expression for Parotid Gland Cancer

Search GEO for disease gene expression data for Parotid Gland Cancer.

Pathways for Parotid Gland Cancer

GO Terms for Parotid Gland Cancer

Biological processes related to Parotid Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 8.62 ANKRD11 FLCN

Sources for Parotid Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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