MCID: PRT009
MIFTS: 32

Parotid Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Parotid Gland Cancer

MalaCards integrated aliases for Parotid Gland Cancer:

Name: Parotid Gland Cancer 12 15
Parotid Neoplasms 44 73
Malignant Neoplasm of the Parotid 12
Malignant Tumor of Parotid Gland 12
Cancer of Parotid Gland 12
Cancer of Parotid 73
Parotid Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9036
ICD10 33 C07
ICD9CM 35 142.0
MeSH 44 D010307
NCIt 50 C3525
SNOMED-CT 68 93949007

Summaries for Parotid Gland Cancer

Disease Ontology : 12 A salivary gland cancer that is located in the parotid gland.

MalaCards based summary : Parotid Gland Cancer, also known as parotid neoplasms, is related to parotid gland adenoid cystic carcinoma and adenoma. An important gene associated with Parotid Gland Cancer is BCYRN1 (Brain Cytoplasmic RNA 1). The drugs Pembrolizumab and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, skin and lymph node.

Related Diseases for Parotid Gland Cancer

Diseases related to Parotid Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 parotid gland adenoid cystic carcinoma 11.2
2 adenoma 10.0
3 adenocarcinoma 9.9
4 pleomorphic adenoma 9.9
5 pilomatrixoma 9.8
6 hyperhidrosis, gustatory 9.8
7 prostate cancer 9.8
8 hemangiopericytoma, malignant 9.8
9 oncocytoma 9.8
10 facial paralysis 9.7
11 actinomycosis 9.7
12 mycobacterium abscessus 9.7

Comorbidity relations with Parotid Gland Cancer via Phenotypic Disease Network (PDN):


Facial Paralysis

Graphical network of the top 20 diseases related to Parotid Gland Cancer:



Diseases related to Parotid Gland Cancer

Symptoms & Phenotypes for Parotid Gland Cancer

Drugs & Therapeutics for Parotid Gland Cancer

Drugs for Parotid Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2
Bevacizumab Approved, Investigational Phase 1 216974-75-3
3
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
4
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
5 Angiogenesis Modulating Agents Phase 1
6
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
7 Protein Kinase Inhibitors Phase 1
8 Antimitotic Agents Phase 1
9 Angiogenesis Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors Unknown status NCT01216800 Phase 3
2 Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158) Recruiting NCT02628067 Phase 2
3 Phase I of Biologics and Chemoradiation Therapy for Advanced Head and Neck Cancer Completed NCT00405405 Phase 1 Cisplatin;Docetaxel;Bevacizumab;Erlotinib
4 Optical Detection of Peripheral Nerve Bundles During Surgery Completed NCT01731379

Search NIH Clinical Center for Parotid Gland Cancer

Cochrane evidence based reviews: parotid neoplasms

Genetic Tests for Parotid Gland Cancer

Anatomical Context for Parotid Gland Cancer

MalaCards organs/tissues related to Parotid Gland Cancer:

41
Salivary Gland, Skin, Lymph Node, Colon, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Parotid Gland Cancer:

19
The Parotid Gl

Publications for Parotid Gland Cancer

Articles related to Parotid Gland Cancer:

(show top 50) (show all 56)
# Title Authors Year
1
Comparing the RTOG/EORTC and LENT-SOMA scoring systems for the evaluation of late skin toxicity after<sup>125</sup>I seed brachytherapy for parotid gland cancer. ( 29406124 )
2018
2
Comparing the RTOG/EORTC and LENT-SOMA scoring systems for the evaluation of late skin toxicity after (125)I seed brachytherapy for parotid gland cancer. ( 28495444 )
2017
3
Prognostic relevance of epithelial-mesenchymal transition and proliferation in surgically treated primary parotid gland cancer. ( 27729431 )
2016
4
Prediction of outcome by lymph node ratio in patients with parotid gland cancer. ( 27185037 )
2016
5
Surgery for Primary Malignant Parotid Neoplasms. ( 27093700 )
2016
6
Prognostic Factors and Treatment Outcomes of Parotid Gland Cancer: A 10-Year Single-Center Experience. ( 26203086 )
2015
7
Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity. ( 26053092 )
2015
8
Use of fine-needle aspiration cytology in the diagnosis of parotid neoplasms. ( 25424665 )
2015
9
Diagnostic investigation of parotid neoplasms: a 16-year experience of freehand fine needle aspiration cytology and ultrasound-guided core needle biopsy. ( 25457828 )
2015
10
Paediatric parotid neoplasms: a 10 year retrospective imaging and pathology review of these rare tumours. ( 25515793 )
2015
11
Incidental Parotid Neoplasms: Pathology and Prevalence. ( 26019135 )
2015
12
Retrospective Assessment of the Utility of Imaging, Fine-Needle Aspiration Biopsy, and Intraoperative Frozen Section in the Management of Parotid Neoplasms: The Weill Cornell Medical College Experience. ( 26159894 )
2015
13
Re: Use of fine-needle aspiration cytology in the diagnosis of parotid neoplasms. ( 26498567 )
2015
14
Facial nerve reconstruction following radical parotidectomy and subtotal petrosectomy for advanced malignant parotid neoplasms. ( 26981471 )
2015
15
The incidence of radioepidermitis and the dose-response relationship in parotid gland cancer patients treated with 125I seed brachytherapy : Incidence of radioepidermitis and the dose-response relationship. ( 25200358 )
2014
16
An exploratory study of long-term health-related quality of life in patients with surgically treated primary parotid gland cancer. ( 25223976 )
2014
17
Diagnostic value of CT perfusion imaging for parotid neoplasms. ( 24186883 )
2014
18
Robotically assisted selective neck dissection in parotid gland cancer: preliminary report. ( 23208780 )
2013
19
Occurrence of lymph node metastasis in early-stage parotid gland cancer. ( 21671057 )
2012
20
Prognostic value of proliferating cell nuclear antigen in parotid gland cancer. ( 21874325 )
2012
21
Preliminary results of (125)I interstitial brachytherapy for locally recurrent parotid gland cancer in previously irradiated patients. ( 22488812 )
2012
22
Sonoelastography techniques in the evaluation and diagnosis of parotid neoplasms. ( 22367472 )
2012
23
Prognostic value of survivin expression in parotid gland cancer in consideration of different histological subtypes. ( 21397494 )
2011
24
An overview of the rare parotid gland cancer. ( 21917153 )
2011
25
Discrimination of parotid neoplasms from the normal parotid gland by use of Raman spectroscopy and support vector machine. ( 21439894 )
2011
26
Synchronous unilateral parotid neoplasms. A case report. ( 19179956 )
2009
27
Parotid neoplasms: analysis of 600 patients attended at a single institution. ( 19784416 )
2009
28
Gastrointestinal: isolated colonic metastasis from parotid gland cancer. ( 18699984 )
2008
29
An ileal metastasis from a parotid gland cancer that mimicked a flat adenoma. ( 17285507 )
2007
30
Massive deep lobe parotid neoplasms and parapharyngeal space-occupying lesions: contemporary diagnostics and surgical approaches. ( 17921922 )
2007
31
Preoperative cytology in the management of parotid neoplasms. ( 16500471 )
2006
32
Integrin receptors and extracellular matrix components in parotid neoplasms. ( 15812349 )
2005
33
Use of cross-sectional imaging in predicting surgical location of parotid neoplasms. ( 15891497 )
2005
34
Genetic expression profiling of parotid neoplasms by cDNA microarrays. ( 16450770 )
2005
35
Parotid gland cancer: a case report of a primitive adenocarcinoma arising from a multirecurrent pleomorphic adenoma. ( 15149165 )
2004
36
We present our experience employing magnetic resonance imaging (MRI) for the preoperative assessment of the patients with parotid gland cancer. ( 15366759 )
2004
37
Use of cross-sectional imaging in predicting facial nerve sacrifice during surgery for parotid neoplasms. ( 15583440 )
2004
38
Patients' perspectives on the short- and long-term outcomes following surgery for benign parotid neoplasms. ( 12956917 )
2003
39
Parotid neoplasms in children: experience of diagnosis and management in a district general hospital. ( 14505619 )
2003
40
Parotid neoplasms: diagnosis, treatment, and intraparotid facial nerve anatomy. ( 12080993 )
2002
41
Synchronous occurrence of 2 histologically distinct parotid neoplasms. ( 10847294 )
2000
42
Synchronous unilateral parotid neoplasms of different histological types. ( 10383249 )
1999
43
Society of Surgical Oncology Practice Guidelines. Parotid gland cancer surgical practice guidelines. ( 9268982 )
1997
44
Bilateral parotid neoplasms. ( 7822187 )
1994
45
Subtotal petrosectomy in the management of advanced parotid neoplasms. ( 8464641 )
1993
46
Prognostic variables in parotid gland cancer. ( 1747227 )
1991
47
Synchronous unilateral parotid neoplasms of different histologic types. ( 2542187 )
1989
48
Amylase expression in human parotid neoplasms: evidence by in situ hybridization for lack of transcription of the amylase gene. ( 2451689 )
1988
49
ABO (H) cell surface antigens in benign and malignant parotid neoplasms. ( 6314050 )
1983
50
The management of parotid neoplasms. ( 6163750 )
1981

Variations for Parotid Gland Cancer

Expression for Parotid Gland Cancer

Search GEO for disease gene expression data for Parotid Gland Cancer.

Pathways for Parotid Gland Cancer

GO Terms for Parotid Gland Cancer

Biological processes related to Parotid Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 8.62 ANKRD11 FLCN

Sources for Parotid Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....