MCID: PRT009
MIFTS: 37

Parotid Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Oral diseases
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Aliases & Classifications for Parotid Gland Cancer

MalaCards integrated aliases for Parotid Gland Cancer:

Name: Parotid Gland Cancer 11 14
Cancer of Parotid Gland 11 33
Parotid Neoplasms 43 71
Primary Malignant Neoplasm of Parotid Gland 33
Malignant Neoplasm of the Parotid 11
Malignant Tumour of Parotid Gland 33
Malignant Tumor of Parotid Gland 11
Parotid Glandular Cancer 33
Parotid Gland Carcinoma 16
Parotid Ductal Cancer 33
Parotid Duct Cancer 33
Cancer of Parotid 71
Parotid Neoplasm 16
Parotid Cancer 11

Classifications:



External Ids:

Disease Ontology 11 DOID:9036
ICD9CM 34 142.0
MeSH 43 D010307
NCIt 49 C3525
SNOMED-CT 68 93949007
ICD10 31 C07
UMLS 71 C0030581 C0747273

Summaries for Parotid Gland Cancer

Disease Ontology: 11 A salivary gland cancer that is located in the parotid gland.

MalaCards based summary: Parotid Gland Cancer, also known as cancer of parotid gland, is related to adenoid cystic carcinoma and acinar cell carcinoma. An important gene associated with Parotid Gland Cancer is BCYRN1 (Brain Cytoplasmic RNA 1), and among its related pathways/superpathways are Hepatocyte growth factor receptor signaling and MAPK Signaling: Mitogens. The drugs Pembrolizumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include parotid gland, salivary gland and lymph node.

Related Diseases for Parotid Gland Cancer

Diseases related to Parotid Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 29.8 TP53 NTRK3 ERBB2
2 acinar cell carcinoma 29.8 NTRK3 MAML2 ETV6
3 mixed cell type cancer 29.7 TP53 ERBB2
4 epithelial-myoepithelial carcinoma 29.6 NTRK3 MAML2 ETV6
5 salivary gland carcinoma 29.6 TP53 NTRK3 MAML2 ETV6 ERBB2
6 skin squamous cell carcinoma 29.3 TP53 ERBB2
7 pleomorphic adenoma carcinoma 28.8 TP53 NTRK3 MAML2 ETV6 ERBB2
8 parotid gland adenoid cystic carcinoma 11.2
9 bell's palsy 10.3
10 warthin tumor 10.2
11 breast squamous cell carcinoma 10.2 ERBB2 BCYRN1
12 pregnancy adenoma 10.1 NTRK3 ETV6
13 cellular congenital mesoblastic nephroma 10.1 NTRK3 ETV6
14 congenital mesoblastic nephroma 10.1 NTRK3 ETV6
15 nephroma 10.1 NTRK3 ETV6
16 adult fibrosarcoma 10.1 NTRK3 ETV6
17 lipofibromatosis-like neural tumor 10.1 NTRK3 ETV6
18 mixed lacrimal gland cancer 10.1 NTRK3 ETV6
19 kidney fibrosarcoma 10.1 NTRK3 ETV6
20 gastric adenosquamous carcinoma 10.1 TP53 CAGE1
21 kidney cortex disease 10.1 NTRK3 ETV6
22 childhood fibrosarcoma 10.1 NTRK3 ETV6
23 adult teratoma 10.1 TP53 ETV6
24 pleomorphic adenoma 10.1
25 adenoma 10.1
26 infantile myofibromatosis 10.1 NTRK3 ETV6
27 congenital fibrosarcoma 10.1 NTRK3 ETV6
28 necrotizing sialometaplasia 10.1 TP53 MAML2
29 diamond-blackfan anemia 11 10.1 TP53 ETV6
30 differentiated thyroid carcinoma 10.1 NTRK3 ETV6
31 laryngeal benign neoplasm 10.1 TP53 CAGE1
32 papillary cystadenocarcinoma 10.1 TP53 MAML2
33 kidney benign neoplasm 10.1 NTRK3 ETV6
34 eccrine sweat gland cancer 10.1 TP53 MAML2
35 hyperhidrosis, gustatory 10.1
36 hypopharynx cancer 10.1 TP53 CAGE1
37 sweat gland benign neoplasm 10.1 TP53 MAML2
38 apocrine adenosis of breast 10.0 TP53 ERBB2
39 gestational ovarian choriocarcinoma 10.0 TP53 ERBB2
40 comedo carcinoma 10.0 TP53 ERBB2
41 breast sarcoma 10.0 TP53 ERBB2
42 salivary gland adenoid cystic carcinoma 10.0 TP53 NTRK3
43 breast malignant phyllodes tumor 10.0 TP53 ERBB2
44 apocrine adenocarcinoma 10.0 TP53 ERBB2
45 localized osteosarcoma 10.0 TP53 ERBB2
46 ovarian carcinosarcoma 10.0 TP53 ERBB2
47 intraductal breast benign neoplasm 10.0 TP53 ERBB2
48 breast benign neoplasm 10.0 TP53 ERBB2
49 synchronous bilateral breast carcinoma 10.0 TP53 ERBB2
50 esophageal adenosquamous carcinoma 10.0 TP53 ERBB2

Comorbidity relations with Parotid Gland Cancer via Phenotypic Disease Network (PDN):


Facial Paralysis

Graphical network of the top 20 diseases related to Parotid Gland Cancer:



Diseases related to Parotid Gland Cancer

Symptoms & Phenotypes for Parotid Gland Cancer

Drugs & Therapeutics for Parotid Gland Cancer

Drugs for Parotid Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4 254741536
2 Antineoplastic Agents, Immunological Phase 2
3
Cisplatin Approved Phase 1 15663-27-1 2767 5702198 441203
4
Erlotinib Approved, Investigational Phase 1 183319-69-9, 183321-74-6 176870
5
Bevacizumab Approved, Investigational Phase 1 216974-75-3 135329020
6
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
7 Antimitotic Agents Phase 1
8 Angiogenesis Inhibitors Phase 1
9 Tubulin Modulators Phase 1
10 Protein Kinase Inhibitors Phase 1
11
Sodium citrate Approved, Investigational 68-04-2 23431961
12
Ethanol Approved 64-17-5 702
13
Methylene blue Approved, Investigational 61-73-4 6099
14
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
15 Calcium, Dietary
16 Anticoagulants
17 Citrate
18 Chelating Agents
19 Anti-Infective Agents
20 Anti-Infective Agents, Local
21 Pharmaceutical Solutions
22
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 The Use of Human Acellular Dermal Matrix in the Prevention of Infraauricular Depressed Deformities and Frey's Syndrome Following Total Parotidectomy Completed NCT01414790 Phase 3
2 Phase 1/2 Trial of ALM-488 in Patients Undergoing Head & Neck Surgery Completed NCT04420689 Phase 1, Phase 2 ALM-488
3 A Clinical Trial of Pembrolizumab (MK-3475) Evaluating Predictive Biomarkers in Subjects With Advanced Solid Tumors (KEYNOTE 158) Recruiting NCT02628067 Phase 2
4 A Phase I Study of the Combination of Chemoradiotherapy With Biologic Therapy for Advanced Head and Neck Cancer Completed NCT00405405 Phase 1 Cisplatin;Docetaxel;Bevacizumab;Erlotinib
5 Feasibility Study of MRI Imaging on Parotid Gland Stimulation Unknown status NCT02294838
6 Accuracy of Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology in the Preoperative Work-Up of Parotid Gland Neoplasms Unknown status NCT03849482
7 Accuracy of Fine Needle Aspiration Biopsy in the Pre-Operative Diagnosis of Malignancy in Patients With Parotid Gland Masses Unknown status NCT00534612 Early Phase 1
8 Intra-parotid Facial Nerve by MRI Tractography: Clinical vs Radiologic Description in Parotid Tumors Unknown status NCT03950323
9 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226
10 Trident Landmark as a Safe and Easy Method for Facial Nerve Trunk Identification During Superficial Parotidectomy Completed NCT04803032
11 Human Salivary Gland Disposition of Alda-341 in Patients Undergoing Salivary Gland Surgery Completed NCT04296266 Early Phase 1 Alda-341
12 Postoperative Facial Weakness in Parotidectomy for Deep Seated Parotid Tumor With or Without Intra-parotid Facial Nerve Imaging (3D Double-Echo Steady-State With Water Excitation MRI Imaging) Completed NCT03822728
13 Retrospective Clinical Outcome of Parotid Tumor Surgery Completed NCT01983176
14 Role of MRI and Fine Needle Aspiration in the Diagnosis of Parotid Tumors Completed NCT05152056
15 Application of 3D Magnetic Resonance Neurogram Sequences for Evaluation of Intraparotid Facial Nerves in Patients With Parotid Neoplasm Recruiting NCT05296109
16 FArial NErf MRI in the Preoperative Assessment of PArotide Tumors Recruiting NCT04613349
17 Comparison Between Ultrasound-Guided Ethanol Sclerotherapy (UGES) & Surgical Excision in Management of Warthin Tumor of Parotid Gland. Recruiting NCT05221736
18 A Randomized Study of Head and Neck Radiotherapy With or Without Customized 3D Printed Oral Stents Recruiting NCT04870762
19 Pattern and Outcome of Surgical Treatment of Parotid Gland Neoplasms in Upper Egypt(Retrospective Study) Recruiting NCT05505318
20 Role of Methylene Blue Dye in Identification of Facial Nerve in Parotid Surgery Not yet recruiting NCT05401370
21 Study of the Facial Nerve in MRI 3T in the Preoperative Assessment of Parotid Tumors Withdrawn NCT04104802

Search NIH Clinical Center for Parotid Gland Cancer

Cochrane evidence based reviews: parotid neoplasms

Genetic Tests for Parotid Gland Cancer

Anatomical Context for Parotid Gland Cancer

Organs/tissues related to Parotid Gland Cancer:

FMA: Parotid Gland
MalaCards : Salivary Gland, Lymph Node, Adrenal Gland, Thyroid, Neutrophil, Skin, Breast

Publications for Parotid Gland Cancer

Articles related to Parotid Gland Cancer:

(show top 50) (show all 398)
# Title Authors PMID Year
1
Cytology as a rapid tool in diagnosing tuberculosis of the parotid gland: A case series with a review of the literature. 62
35924792 2022
2
Initial neutrophil-to-lymphocyte ratio predicts radiation-induced trismus in parotid gland cancer. 62
36349491 2022
3
Is elective neck dissection necessary for patients with cT3-4N0 parotid gland cancer? 62
35351350 2022
4
BDNF/TRKB axis provokes EMT progression to induce cell aggressiveness via crosstalk with cancer-associated fibroblasts in human parotid gland cancer. 62
36266462 2022
5
Diagnostic Accuracy and Post-Procedural Complications Associated with Ultrasound-Guided Core Needle Biopsy in the Preoperative Evaluation of Parotid Tumors. 62
34919166 2022
6
Does Total Parotidectomy Improve Survival Over Partial Parotidectomy in Early-Stage Adenoid Cystic Carcinoma of the Parotid Gland? 62
35772513 2022
7
[Application of infrared thermography technique to assist peroneal artery perforator flap in the repair of oral and maxillofacial defects]. 62
35979795 2022
8
Pericardial metastasis of parotid mucoepidermoid carcinoma diagnosed by pericardial biopsy. 62
33750609 2022
9
Rapid physical and emotional palliation from QUAD shot radiotherapy to a frail elderly patient with stage IV parotid gland cancer-associated facial paralysis and pain when no other palliative intervention was available during COVID-19 pandemic. 62
35617749 2022
10
Multimodal magnetic resonance imaging for the diagnosis of parotid gland malignancies: systematic review and meta-analysis. 62
35966327 2022
11
Role of Intraparotid and Neck Lymph Node Metastasis in Primary Parotid Cancer Surgery: A Population-Based Analysis. 62
35740490 2022
12
Indications and outcomes for elective dissection of level V in primary parotid cancer. 62
35302270 2022
13
Ulcerative Warthin Tumor: A Case Report and Review of the Literature. 62
32931334 2022
14
[Surgery for parotid gland cancer-controversial and proven aspects]. 62
35579674 2022
15
A Deep Learning Model for Classification of Parotid Neoplasms Based on Multimodal Magnetic Resonance Image Sequences. 62
35575610 2022
16
[Clinicopathologic analysis of micro and mini parotid gland tumors]. 62
35435201 2022
17
Image fusion technique for target volume delineation in 125I seed implant brachytherapy for parotid gland cancers. 62
35645116 2022
18
A Case of Recurrent Metastatic Parotid Acinic Cell Carcinoma Responsive to Pembrolizumab. 62
35241570 2022
19
[Preservation, reconstruction, and rehabilitation of the facial nerve]. 62
35288765 2022
20
Remote-access hemithyroidectomy in a patient with papillary thyroid cancer after ipsilateral irradiation: a case report. 62
35402203 2022
21
Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas. 62
34716197 2022
22
Metastatic Parotid Gland Carcinoma With ERBB2 Amplification With Complete Response to Fam-Trastuzumab Deruxtecan. 62
35130504 2022
23
Preoperative Magnetic Resonance Image and Computerized Tomography Findings Predictive of Facial Nerve Invasion in Patients with Parotid Cancer without Preoperative Facial Weakness-A Retrospective Observational Study. 62
35205832 2022
24
Current Issues in Treatment of Parotid Gland Cancer and Advanced Surgical Technique of Robotic Parotidectomy. 62
35061197 2022
25
Prediction of Long-Term Survival Outcome by Lymph Node Ratio in Patients of Parotid Gland Cancer: A Retrospective study. 62
35647020 2022
26
[Application of free peroneal artery chimeric perforator flap in repairing the defect after advanced local lesions resection in parotid gland carcinoma]. 62
35038803 2022
27
Pretherapeutic Predictive Factors for Histological High-Grade Parotid Gland Carcinoma. 62
34245171 2022
28
Predicting cancer-specific mortality in patients with parotid gland carcinoma by competing risk nomogram. 62
34632674 2021
29
Prognostic indicators in clinically node-negative malignant primary salivary tumours of the parotid: A multicentre experience. 62
34742011 2021
30
Interpretation of Timetrends (1996-2017) of the Incidence of Selected Cancers in England in Relation to Mobile Phone Use as a Possible Risk Factor. 62
34633685 2021
31
Long-Term Facial Nerve Outcome in Primary Parotid Cancer Surgery: A Population-Based Analysis. 62
34050959 2021
32
Skin Dosimetry with EBT3 Radiochromic Film in Radiotherapy of Parotid Cancer. 62
34722402 2021
33
Pre-treatment MRI predictor of high-grade malignant parotid gland cancer. 62
33389599 2021
34
Correction to: Pre-treatment MRI predictor of high-grade malignant parotid gland cancer. 62
33543408 2021
35
Parotid Neurogenic Tumors: MPNST Sarcoma to Schwannoma-Review of Literature and Guidelines in Management. 62
34408362 2021
36
Intraparotid Facial Nerve Schwannoma Mimicking Primary Parotid Neoplasm. 62
34402315 2021
37
Mobile phone use and trends in the incidence of cancers of the parotid and other salivary glands. 62
34020314 2021
38
Survival outcomes in patients with parotid gland carcinoma treated with postoperative therapies using risk stratification. 62
33908675 2021
39
Factors and Outcomes Associated With Temporal Bone Resection for Primary Parotid Malignancy. 62
33797071 2021
40
Targeted DNA profiling and the prevalence of NTRK aberrations in Chinese patients with head and neck cancer. 62
34098386 2021
41
Development and validation of nomograms for predicting survival and recurrence in patients with parotid gland cancer. 62
34527551 2021
42
Rate of Occult Neck Nodal Metastasis in Parotid Cancer: A Meta-Analysis. 62
33175260 2021
43
Prognostic scoring models in parotid gland carcinoma. 62
33734517 2021
44
A Primary Parotid Mucosa-Associated Lymphoid Tissue Non-Hodgkin Lymphoma in a Patient With Sjogren Syndrome. 62
34277270 2021
45
Feasibility and advantages of endoscope-assisted parotidectomy: a systematic review and meta-analysis. 62
33845989 2021
46
Competing-risks nomograms for predicting cause-specific mortality in parotid-gland carcinoma: A population-based analysis. 62
33960711 2021
47
Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review. 62
33169420 2021
48
Prevalence of childhood Cancer among children attending referral hospitals of outpatient Department in Ethiopia. 62
33711955 2021
49
Prognostic Value of the Lymphocyte-to-Monocyte Ratio in Patients with Parotid Gland Carcinoma. 62
32673437 2021
50
Ocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes. 62
31411051 2021

Variations for Parotid Gland Cancer

Expression for Parotid Gland Cancer

Search GEO for disease gene expression data for Parotid Gland Cancer.

Pathways for Parotid Gland Cancer

Pathways related to Parotid Gland Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.76 TP53 NTRK3 ERBB2
2
Show member pathways
11.62 TP53 NTRK3 ERBB2
3
Show member pathways
11.21 TP53 NTRK3 ERBB2
4 10.97 NTRK3 ERBB2
5 10.56 TP53 ERBB2

GO Terms for Parotid Gland Cancer

Sources for Parotid Gland Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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