Parotid Gland Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Parotid Gland Cancer, also known as cancer of parotid gland, is related to adenoid cystic carcinoma and acinar cell carcinoma. An important gene associated with Parotid Gland Cancer is BCYRN1 (Brain Cytoplasmic RNA 1), and among its related pathways/superpathways are Hepatocyte growth factor receptor signaling and MAPK Signaling: Mitogens. The drugs Pembrolizumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include parotid gland, salivary gland and lymph node.

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Related Diseases for Parotid Gland Cancer

Diseases related to Parotid Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)

#	Related Disease	Score	Top Affiliating Genes
1	adenoid cystic carcinoma	29.8	TP53 NTRK3 ERBB2
2	acinar cell carcinoma	29.8	NTRK3 MAML2 ETV6
3	mixed cell type cancer	29.7	TP53 ERBB2
4	epithelial-myoepithelial carcinoma	29.6	NTRK3 MAML2 ETV6
5	salivary gland carcinoma	29.6	TP53 NTRK3 MAML2 ETV6 ERBB2
6	skin squamous cell carcinoma	29.3	TP53 ERBB2
7	pleomorphic adenoma carcinoma	28.8	TP53 NTRK3 MAML2 ETV6 ERBB2
8	parotid gland adenoid cystic carcinoma	11.2
9	bell's palsy	10.3
10	warthin tumor	10.2
11	breast squamous cell carcinoma	10.2	ERBB2 BCYRN1
12	pregnancy adenoma	10.1	NTRK3 ETV6
13	cellular congenital mesoblastic nephroma	10.1	NTRK3 ETV6
14	congenital mesoblastic nephroma	10.1	NTRK3 ETV6
15	nephroma	10.1	NTRK3 ETV6
16	adult fibrosarcoma	10.1	NTRK3 ETV6
17	lipofibromatosis-like neural tumor	10.1	NTRK3 ETV6
18	mixed lacrimal gland cancer	10.1	NTRK3 ETV6
19	kidney fibrosarcoma	10.1	NTRK3 ETV6
20	gastric adenosquamous carcinoma	10.1	TP53 CAGE1
21	kidney cortex disease	10.1	NTRK3 ETV6
22	childhood fibrosarcoma	10.1	NTRK3 ETV6
23	adult teratoma	10.1	TP53 ETV6
24	pleomorphic adenoma	10.1
25	adenoma	10.1
26	infantile myofibromatosis	10.1	NTRK3 ETV6
27	congenital fibrosarcoma	10.1	NTRK3 ETV6
28	necrotizing sialometaplasia	10.1	TP53 MAML2
29	diamond-blackfan anemia 11	10.1	TP53 ETV6
30	differentiated thyroid carcinoma	10.1	NTRK3 ETV6
31	laryngeal benign neoplasm	10.1	TP53 CAGE1
32	papillary cystadenocarcinoma	10.1	TP53 MAML2
33	kidney benign neoplasm	10.1	NTRK3 ETV6
34	eccrine sweat gland cancer	10.1	TP53 MAML2
35	hyperhidrosis, gustatory	10.1
36	hypopharynx cancer	10.1	TP53 CAGE1
37	sweat gland benign neoplasm	10.1	TP53 MAML2
38	apocrine adenosis of breast	10.0	TP53 ERBB2
39	gestational ovarian choriocarcinoma	10.0	TP53 ERBB2
40	comedo carcinoma	10.0	TP53 ERBB2
41	breast sarcoma	10.0	TP53 ERBB2
42	salivary gland adenoid cystic carcinoma	10.0	TP53 NTRK3
43	breast malignant phyllodes tumor	10.0	TP53 ERBB2
44	apocrine adenocarcinoma	10.0	TP53 ERBB2
45	localized osteosarcoma	10.0	TP53 ERBB2
46	ovarian carcinosarcoma	10.0	TP53 ERBB2
47	intraductal breast benign neoplasm	10.0	TP53 ERBB2
48	breast benign neoplasm	10.0	TP53 ERBB2
49	synchronous bilateral breast carcinoma	10.0	TP53 ERBB2
50	esophageal adenosquamous carcinoma	10.0	TP53 ERBB2

Comorbidity relations with Parotid Gland Cancer via Phenotypic Disease Network (PDN):

Facial Paralysis

Graphical network of the top 20 diseases related to Parotid Gland Cancer:

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Symptoms & Phenotypes for Parotid Gland Cancer

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Drugs & Therapeutics for Parotid Gland Cancer

Drugs for Parotid Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Pembrolizumab

Approved

Phase 2

1374853-91-4

254741536

2

Antineoplastic Agents, Immunological

Phase 2

3

Cisplatin

Approved

Phase 1

15663-27-1

2767 5702198 441203

4

Erlotinib

Approved, Investigational

Phase 1

183319-69-9, 183321-74-6

176870

5

Bevacizumab

Approved, Investigational

Phase 1

216974-75-3

135329020

6

Docetaxel

Approved, Investigational

Phase 1

114977-28-5

148124

7

Antimitotic Agents

Phase 1

8

Angiogenesis Inhibitors

Phase 1

9

Tubulin Modulators

Phase 1

10

Protein Kinase Inhibitors

Phase 1

11

Sodium citrate

Approved, Investigational

68-04-2

23431961

12

Ethanol

Approved

64-17-5

702

13

Methylene blue

Approved, Investigational

61-73-4

6099

14

Citric acid

Approved, Nutraceutical, Vet_approved

77-92-9

311

15

Calcium, Dietary

16

Anticoagulants

17

Citrate

18

Chelating Agents

19

Anti-Infective Agents

20

Anti-Infective Agents, Local

21

Pharmaceutical Solutions

22

Calcium

Nutraceutical

7440-70-2

271

Interventional clinical trials:

(show all 21)

#	Name	Status	NCT ID	Phase	Drugs
1	The Use of Human Acellular Dermal Matrix in the Prevention of Infraauricular Depressed Deformities and Frey's Syndrome Following Total Parotidectomy	Completed	NCT01414790	Phase 3
2	Phase 1/2 Trial of ALM-488 in Patients Undergoing Head & Neck Surgery	Completed	NCT04420689	Phase 1, Phase 2	ALM-488
3	A Clinical Trial of Pembrolizumab (MK-3475) Evaluating Predictive Biomarkers in Subjects With Advanced Solid Tumors (KEYNOTE 158)	Recruiting	NCT02628067	Phase 2
4	A Phase I Study of the Combination of Chemoradiotherapy With Biologic Therapy for Advanced Head and Neck Cancer	Completed	NCT00405405	Phase 1	Cisplatin;Docetaxel;Bevacizumab;Erlotinib
5	Feasibility Study of MRI Imaging on Parotid Gland Stimulation	Unknown status	NCT02294838
6	Accuracy of Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology in the Preoperative Work-Up of Parotid Gland Neoplasms	Unknown status	NCT03849482
7	Accuracy of Fine Needle Aspiration Biopsy in the Pre-Operative Diagnosis of Malignancy in Patients With Parotid Gland Masses	Unknown status	NCT00534612	Early Phase 1
8	Intra-parotid Facial Nerve by MRI Tractography: Clinical vs Radiologic Description in Parotid Tumors	Unknown status	NCT03950323
9	Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors	Completed	NCT02527226
10	Trident Landmark as a Safe and Easy Method for Facial Nerve Trunk Identification During Superficial Parotidectomy	Completed	NCT04803032
11	Human Salivary Gland Disposition of Alda-341 in Patients Undergoing Salivary Gland Surgery	Completed	NCT04296266	Early Phase 1	Alda-341
12	Postoperative Facial Weakness in Parotidectomy for Deep Seated Parotid Tumor With or Without Intra-parotid Facial Nerve Imaging (3D Double-Echo Steady-State With Water Excitation MRI Imaging)	Completed	NCT03822728
13	Retrospective Clinical Outcome of Parotid Tumor Surgery	Completed	NCT01983176
14	Role of MRI and Fine Needle Aspiration in the Diagnosis of Parotid Tumors	Completed	NCT05152056
15	Application of 3D Magnetic Resonance Neurogram Sequences for Evaluation of Intraparotid Facial Nerves in Patients With Parotid Neoplasm	Recruiting	NCT05296109
16	FArial NErf MRI in the Preoperative Assessment of PArotide Tumors	Recruiting	NCT04613349
17	Comparison Between Ultrasound-Guided Ethanol Sclerotherapy (UGES) & Surgical Excision in Management of Warthin Tumor of Parotid Gland.	Recruiting	NCT05221736
18	A Randomized Study of Head and Neck Radiotherapy With or Without Customized 3D Printed Oral Stents	Recruiting	NCT04870762
19	Pattern and Outcome of Surgical Treatment of Parotid Gland Neoplasms in Upper Egypt(Retrospective Study)	Recruiting	NCT05505318
20	Role of Methylene Blue Dye in Identification of Facial Nerve in Parotid Surgery	Not yet recruiting	NCT05401370
21	Study of the Facial Nerve in MRI 3T in the Preoperative Assessment of Parotid Tumors	Withdrawn	NCT04104802

Search NIH Clinical Center for Parotid Gland Cancer

Cochrane evidence based reviews: parotid neoplasms

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Genetic Tests for Parotid Gland Cancer

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Anatomical Context for Parotid Gland Cancer

Organs/tissues related to Parotid Gland Cancer:

FMA: Parotid Gland

MalaCards : Salivary Gland, Lymph Node, Adrenal Gland, Thyroid, Neutrophil, Skin, Breast

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Publications for Parotid Gland Cancer

Articles related to Parotid Gland Cancer:

(show top 50) (show all 398)

#	Title	Authors	PMID	Year
1	Cytology as a rapid tool in diagnosing tuberculosis of the parotid gland: A case series with a review of the literature. ⁶²	Kamal N...Singh M	35924792	2022
2	Initial neutrophil-to-lymphocyte ratio predicts radiation-induced trismus in parotid gland cancer. ⁶²	Somay E...Selek U	36349491	2022
3	Is elective neck dissection necessary for patients with cT3-4N0 parotid gland cancer? ⁶²	Adachi M...Hayashi R	35351350	2022
4	BDNF/TRKB axis provokes EMT progression to induce cell aggressiveness via crosstalk with cancer-associated fibroblasts in human parotid gland cancer. ⁶²	Moriwaki K...Asahi M	36266462	2022
5	Diagnostic Accuracy and Post-Procedural Complications Associated with Ultrasound-Guided Core Needle Biopsy in the Preoperative Evaluation of Parotid Tumors. ⁶²	Jering M...Zenk J	34919166	2022
6	Does Total Parotidectomy Improve Survival Over Partial Parotidectomy in Early-Stage Adenoid Cystic Carcinoma of the Parotid Gland? ⁶²	Lee KC...Chuang SK	35772513	2022
7	[Application of infrared thermography technique to assist peroneal artery perforator flap in the repair of oral and maxillofacial defects]. ⁶²	Guo Y...Jiang R	35979795	2022
8	Pericardial metastasis of parotid mucoepidermoid carcinoma diagnosed by pericardial biopsy. ⁶²	Kishida T...Tsukahara K	33750609	2022
9	Rapid physical and emotional palliation from QUAD shot radiotherapy to a frail elderly patient with stage IV parotid gland cancer-associated facial paralysis and pain when no other palliative intervention was available during COVID-19 pandemic. ⁶²	Kil WJ	35617749	2022
10	Multimodal magnetic resonance imaging for the diagnosis of parotid gland malignancies: systematic review and meta-analysis. ⁶²	Li ZQ...Wan J	35966327	2022
11	Role of Intraparotid and Neck Lymph Node Metastasis in Primary Parotid Cancer Surgery: A Population-Based Analysis. ⁶²	Kouka M...Guntinas-Lichius O	35740490	2022
12	Indications and outcomes for elective dissection of level V in primary parotid cancer. ⁶²	Katz AP...Civantos F	35302270	2022
13	Ulcerative Warthin Tumor: A Case Report and Review of the Literature. ⁶²	Hung CJ...Lin YS	32931334	2022
14	[Surgery for parotid gland cancer-controversial and proven aspects]. ⁶²	Mantsopoulos K...Iro H	35579674	2022
15	A Deep Learning Model for Classification of Parotid Neoplasms Based on Multimodal Magnetic Resonance Image Sequences. ⁶²	Liu X...Liu J	35575610	2022
16	[Clinicopathologic analysis of micro and mini parotid gland tumors]. ⁶²	Li BY...Peng X	35435201	2022
17	Image fusion technique for target volume delineation in 125I seed implant brachytherapy for parotid gland cancers. ⁶²	Li ZY...Zhang J	35645116	2022
18	A Case of Recurrent Metastatic Parotid Acinic Cell Carcinoma Responsive to Pembrolizumab. ⁶²	Yamashita G...Tsukahara K	35241570	2022
19	[Preservation, reconstruction, and rehabilitation of the facial nerve]. ⁶²	Thielker J...Guntinas-Lichius O	35288765	2022
20	Remote-access hemithyroidectomy in a patient with papillary thyroid cancer after ipsilateral irradiation: a case report. ⁶²	Ho K...Ando N	35402203	2022
21	Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas. ⁶²	Meric-Bernstam F...Luke JJ	34716197	2022
22	Metastatic Parotid Gland Carcinoma With ERBB2 Amplification With Complete Response to Fam-Trastuzumab Deruxtecan. ⁶²	Shukla ND...Colevas AD	35130504	2022
23	Preoperative Magnetic Resonance Image and Computerized Tomography Findings Predictive of Facial Nerve Invasion in Patients with Parotid Cancer without Preoperative Facial Weakness-A Retrospective Observational Study. ⁶²	Cho WK...Kim SY	35205832	2022
24	Current Issues in Treatment of Parotid Gland Cancer and Advanced Surgical Technique of Robotic Parotidectomy. ⁶²	Park YM...Koh YW	35061197	2022
25	Prediction of Long-Term Survival Outcome by Lymph Node Ratio in Patients of Parotid Gland Cancer: A Retrospective study. ⁶²	Jiang WM...Chen YF	35647020	2022
26	[Application of free peroneal artery chimeric perforator flap in repairing the defect after advanced local lesions resection in parotid gland carcinoma]. ⁶²	Yang D...Sun Y	35038803	2022
27	Pretherapeutic Predictive Factors for Histological High-Grade Parotid Gland Carcinoma. ⁶²	Mikoshiba T...Ogawa K	34245171	2022
28	Predicting cancer-specific mortality in patients with parotid gland carcinoma by competing risk nomogram. ⁶²	Luo X...Zeng X	34632674	2021
29	Prognostic indicators in clinically node-negative malignant primary salivary tumours of the parotid: A multicentre experience. ⁶²	Fussey J...Boscolo-Rizzo P	34742011	2021
30	Interpretation of Timetrends (1996-2017) of the Incidence of Selected Cancers in England in Relation to Mobile Phone Use as a Possible Risk Factor. ⁶²	de Vocht F	34633685	2021
31	Long-Term Facial Nerve Outcome in Primary Parotid Cancer Surgery: A Population-Based Analysis. ⁶²	Thielker J...Guntinas-Lichius O	34050959	2021
32	Skin Dosimetry with EBT3 Radiochromic Film in Radiotherapy of Parotid Cancer. ⁶²	Bahreyni Toossi MT...Dayani M	34722402	2021
33	Pre-treatment MRI predictor of high-grade malignant parotid gland cancer. ⁶²	Baba A...Ojiri H	33389599	2021
34	Correction to: Pre-treatment MRI predictor of high-grade malignant parotid gland cancer. ⁶²	Baba A...Ojiri H	33543408	2021
35	Parotid Neurogenic Tumors: MPNST Sarcoma to Schwannoma-Review of Literature and Guidelines in Management. ⁶²	Chandra SR...Wolf A	34408362	2021
36	Intraparotid Facial Nerve Schwannoma Mimicking Primary Parotid Neoplasm. ⁶²	Bewley AF...Borrelli M	34402315	2021
37	Mobile phone use and trends in the incidence of cancers of the parotid and other salivary glands. ⁶²	Karipidis K...Elwood M	34020314	2021
38	Survival outcomes in patients with parotid gland carcinoma treated with postoperative therapies using risk stratification. ⁶²	Wei ZG...Zhang Z	33908675	2021
39	Factors and Outcomes Associated With Temporal Bone Resection for Primary Parotid Malignancy. ⁶²	Tanavde VA...Creighton FX	33797071	2021
40	Targeted DNA profiling and the prevalence of NTRK aberrations in Chinese patients with head and neck cancer. ⁶²	Xu J...Liu L	34098386	2021
41	Development and validation of nomograms for predicting survival and recurrence in patients with parotid gland cancer. ⁶²	Wei Z...Peng X	34527551	2021
42	Rate of Occult Neck Nodal Metastasis in Parotid Cancer: A Meta-Analysis. ⁶²	Warshavsky A...Horowitz G	33175260	2021
43	Prognostic scoring models in parotid gland carcinoma. ⁶²	Westergaard-Nielsen M...Bjorndal K	33734517	2021
44	A Primary Parotid Mucosa-Associated Lymphoid Tissue Non-Hodgkin Lymphoma in a Patient With Sjogren Syndrome. ⁶²	Povlow MR...Jaramillo C	34277270	2021
45	Feasibility and advantages of endoscope-assisted parotidectomy: a systematic review and meta-analysis. ⁶²	Zou HW...Chen HY	33845989	2021
46	Competing-risks nomograms for predicting cause-specific mortality in parotid-gland carcinoma: A population-based analysis. ⁶²	Xu F...Lyu J	33960711	2021
47	Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review. ⁶²	Guntinas-Lichius O...Ferlito A	33169420	2021
48	Prevalence of childhood Cancer among children attending referral hospitals of outpatient Department in Ethiopia. ⁶²	Endalamaw A...Wubneh CA	33711955	2021
49	Prognostic Value of the Lymphocyte-to-Monocyte Ratio in Patients with Parotid Gland Carcinoma. ⁶²	Mikoshiba T...Ogawa K	32673437	2021
50	Ocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes. ⁶²	Sarangi J...Sharma MC	31411051	2021

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Genes for Parotid Gland Cancer

Genes related to Parotid Gland Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	BCYRN1	Brain Cytoplasmic RNA 1	RNA Gene	150	Experimental evidence: Regulation ³⁷	9422992
2	MIR4695	MicroRNA 4695	RNA Gene	5.08	DISEASES inferred ¹⁴
3	CAGE1	Cancer Antigen 1	Protein Coding	5.02	DISEASES inferred ¹⁴
4	ETV6	ETS Variant Transcription Factor 6	Protein Coding	5.01	DISEASES inferred ¹⁴
5	MAML2	Mastermind Like Transcriptional Coactivator 2	Protein Coding	4.92	DISEASES inferred ¹⁴
6	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	4.8	DISEASES inferred ¹⁴
7	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	4.77	DISEASES inferred ¹⁴
8	TNS4	Tensin 4	Protein Coding	4.66	DISEASES inferred ¹⁴
9	SLC26A9	Solute Carrier Family 26 Member 9	Protein Coding	4.62	DISEASES inferred ¹⁴
10	TP53	Tumor Protein P53	Protein Coding	4.6	DISEASES inferred ¹⁴

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Variations for Parotid Gland Cancer

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Expression for Parotid Gland Cancer

Search GEO for disease gene expression data for Parotid Gland Cancer.

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Pathways for Parotid Gland Cancer

Pathways related to Parotid Gland Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Hepatocyte growth factor receptor signaling ⁷⁴ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development HGF signaling pathway ²² Development Neurotrophin family signaling ²² Drug-mediated inhibition of MET activation ⁶⁶ MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ PLC-gamma1 signalling ⁶⁶ Trk receptor signaling mediated by PI3K and PLC-gamma ⁶¹ TRKA activation by NGF ⁶⁶	11.76	TP53 NTRK3 ERBB2
2	MAPK Signaling: Mitogens ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	11.62	TP53 NTRK3 ERBB2
3	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	11.21	TP53 NTRK3 ERBB2
4	Alzheimers Disease Pathway ⁶⁴	10.97	NTRK3 ERBB2
5	Bladder cancer ⁷⁴	10.56	TP53 ERBB2

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GO Terms for Parotid Gland Cancer

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Sources for Parotid Gland Cancer

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: PRT009 MIFTS: 37	Parotid Gland Cancer Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Oral diseases	Data Licensing For inquiries, contact: [email protected]
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