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MCID: PRT009
MIFTS: 46

Parotid Gland Cancer

Categories: Cancer diseases, Oral diseases, Gastrointestinal diseases, Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Parotid Gland Cancer

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MalaCards integrated aliases for Parotid Gland Cancer:

Name: Parotid Gland Cancer 12 15
Parotid Neoplasms 44 73
Malignant Neoplasm of the Parotid 12
Malignant Tumor of Parotid Gland 12
Cancer of Parotid Gland 12
Cancer of Parotid 73
Parotid Cancer 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Oral diseases Gastrointestinal diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9036
ICD10 33 C07
ICD9CM 35 142.0
MeSH 44 D010307
NCIt 50 C3525
SNOMED-CT 68 363379000 93949007
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Summaries for Parotid Gland Cancer

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Disease Ontology : 12 A salivary gland cancer that is located in the parotid gland.

MalaCards based summary : Parotid Gland Cancer, also known as parotid neoplasms, is related to adenocarcinoma and prostate cancer. An important gene associated with Parotid Gland Cancer is BCYRN1 (Brain Cytoplasmic RNA 1
BC200 RNA was expressed in carcinomas of the breast,cervix,oesophagus,lung,ovary,parotid,and tongue,but not in corresponding normal tissues.
Dysfunction Pattern: Regulation [up-regulated]), and among its related pathways/superpathways are Developmental Biology and Endometrial cancer. The drugs Pembrolizumab and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include the parotid gl, salivary gland and lymph node, and related phenotypes are Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line and Increased mitotic index

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Related Diseases for Parotid Gland Cancer

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Diseases related to Parotid Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 27.3 ALK CDH1 ERBB4 PIK3CA RET SMAD4
2 prostate cancer 26.9 CDH1 ESR2 KRT8 MET MMP14 MMP7
3 parotid gland adenoid cystic carcinoma 11.0
4 sarcoma, synovial 10.2 CDH1 KRT8 MET
5 spinal chordoma 10.1 KRT8 MET PIK3CA
6 breast ductal carcinoma 10.0 CDH1 KRT8 MET
7 anaplastic thyroid cancer 10.0 CDH1 MET PIK3CA
8 serous cystadenocarcinoma 10.0 ESR2 MMP14 PIK3CA
9 squamous cell carcinoma of the oral tongue 10.0 CDH1 PIK3CA
10 hypotrichosis, congenital, with juvenile macular dystrophy 9.9 CDH1 CDH17
11 adenoma 9.9
12 light chain deposition disease 9.9 MMP14 MMP7
13 uterine carcinosarcoma 9.8 CDH1 ESR2 PIK3CA
14 pleomorphic adenoma 9.8
15 mucoepidermoid carcinoma 9.8
16 pancreas adenocarcinoma 9.7 CDH1 PIK3CA SMAD4
17 papillary carcinoma 9.7 CDH1 MET RET
18 endocrine gland cancer 9.7 CDH1 RET SMAD4
19 hyperhidrosis, gustatory 9.7
20 hemangiopericytoma, malignant 9.7
21 oncocytoma 9.7
22 prostatitis 9.7
23 gastrointestinal system cancer 9.7 CDH1 MET PIK3CA SMAD4
24 cowden disease 9.7 PIK3CA RET SMAD4
25 squamous cell carcinoma, head and neck 9.6 CDH1 MMP14 PIK3CA SMAD4
26 actinomycosis 9.6
27 mycobacterium abscessus 9.6
28 squamous cell carcinoma 9.5 BCYRN1 CDH1 ERBB4 PIK3CA SMAD4
29 adenosquamous cell lung carcinoma 9.5 ALK PIK3CA RET
30 differentiated thyroid carcinoma 9.5 ALK MET RET
31 respiratory system cancer 9.5 ALK CDH1 MET PIK3CA
32 esophageal cancer 9.3 BCYRN1 CDH1 MMP7 PIK3CA SMAD4
33 lung cancer susceptibility 3 9.0 ALK CDH1 MET PIK3CA SMAD4
34 cholangiocarcinoma 9.0 CDH1 KRT8 MET MMP7 PIK3CA SMAD4
35 gastric adenocarcinoma 8.7 CDH1 CDH17 KRT8 MET PIK3CA SMAD4
36 gastric cancer 8.7 CDH1 CDH17 MET PIK3CA SMAD4
37 breast cancer 7.3 ALK BCYRN1 CDH1 ERBB4 ESR2 KRT8
38 colorectal cancer 7.1 BCYRN1 CDH1 ESR2 KRT8 MET MMP14

Comorbidity relations with Parotid Gland Cancer via Phenotypic Disease Network (PDN):


Facial Paralysis

Graphical network of the top 20 diseases related to Parotid Gland Cancer:



Diseases related to Parotid Gland Cancer
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Symptoms & Phenotypes for Parotid Gland Cancer

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GenomeRNAi Phenotypes related to Parotid Gland Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line GR00121-A 8.96 ERBB4 MET
2 Increased mitotic index GR00110-A-0 8.8 MET RET SMAD4

MGI Mouse Phenotypes related to Parotid Gland Cancer:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.31 CDH1 ERBB4 ESR2 KRT8 MET MMP14
2 cellular MP:0005384 10.3 SMAD4 SPI1 ZIC3 CDH1 ERBB4 ESR2
3 growth/size/body region MP:0005378 10.29 ALK CDH1 ESR2 KRT8 MET MMP14
4 immune system MP:0005387 10.29 CDH17 ERBB4 ESR2 KRT8 MET MMP14
5 mortality/aging MP:0010768 10.28 ALK CDH1 ERBB4 ESR2 KRT8 MET
6 endocrine/exocrine gland MP:0005379 10.22 ALK CDH1 ERBB4 ESR2 MET MMP14
7 digestive/alimentary MP:0005381 10.2 CDH1 ESR2 KRT8 MET MMP14 MMP7
8 embryo MP:0005380 10.19 CDH1 ERBB4 KRT8 MET MMP14 PIK3CA
9 hematopoietic system MP:0005397 10.19 CDH17 ERBB4 ESR2 KRT8 MMP14 MMP7
10 neoplasm MP:0002006 10.02 ALK CDH1 ESR2 MET MMP7 PIK3CA
11 nervous system MP:0003631 10.02 ERBB4 ESR2 MET MMP14 PIK3CA RET
12 muscle MP:0005369 9.95 ERBB4 ESR2 MET MMP14 PIK3CA RET
13 limbs/digits/tail MP:0005371 9.93 ESR2 MET MMP14 RET SMAD4 ZIC3
14 no phenotypic analysis MP:0003012 9.86 CDH1 ESR2 MET MMP14 PIK3CA RET
15 normal MP:0002873 9.85 SMAD4 SPI1 ZIC3 CDH1 ERBB4 ESR2
16 reproductive system MP:0005389 9.65 ALK CDH1 ERBB4 ESR2 KRT8 MMP14
17 respiratory system MP:0005388 9.17 ALK ERBB4 ESR2 MET MMP14 RET
Sources

Drugs & Therapeutics for Parotid Gland Cancer

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Drugs for Parotid Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
3
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
4
Bevacizumab Approved, Investigational Phase 1 216974-75-3
5
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
6 Angiogenesis Inhibitors Phase 1
7 Angiogenesis Modulating Agents Phase 1
8 Protein Kinase Inhibitors Phase 1
9 Antimitotic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors Unknown status NCT01216800 Phase 3
2 Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158) Recruiting NCT02628067 Phase 2
3 Phase I of Biologics and Chemoradiation Therapy for Advanced Head and Neck Cancer Completed NCT00405405 Phase 1 Cisplatin;Docetaxel;Bevacizumab;Erlotinib
4 Optical Detection of Peripheral Nerve Bundles During Surgery Completed NCT01731379

Search NIH Clinical Center for Parotid Gland Cancer

Cochrane evidence based reviews: parotid neoplasms

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Genetic Tests for Parotid Gland Cancer

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Anatomical Context for Parotid Gland Cancer

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The Foundational Model of Anatomy Ontology organs/tissues related to Parotid Gland Cancer:

19
The Parotid Gl

MalaCards organs/tissues related to Parotid Gland Cancer:

41
Salivary Gland, Lymph Node, Skin, Colon
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Publications for Parotid Gland Cancer

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Articles related to Parotid Gland Cancer:

(show all 21)
# Title Authors Year
1
Comparing the RTOG/EORTC and LENT-SOMA scoring systems for the evaluation of late skin toxicity after<sup>125</sup>I seed brachytherapy for parotid gland cancer. ( 29406124 )
2018
2
Comparing the RTOG/EORTC and LENT-SOMA scoring systems for the evaluation of late skin toxicity after (125)I seed brachytherapy for parotid gland cancer. ( 28495444 )
2017
3
Prognostic relevance of epithelial-mesenchymal transition and proliferation in surgically treated primary parotid gland cancer. ( 27729431 )
2016
4
Prediction of outcome by lymph node ratio in patients with parotid gland cancer. ( 27185037 )
2016
5
Prognostic Factors and Treatment Outcomes of Parotid Gland Cancer: A 10-Year Single-Center Experience. ( 26203086 )
2015
6
Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity. ( 26053092 )
2015
7
The incidence of radioepidermitis and the dose-response relationship in parotid gland cancer patients treated with 125I seed brachytherapy : Incidence of radioepidermitis and the dose-response relationship. ( 25200358 )
2014
8
An exploratory study of long-term health-related quality of life in patients with surgically treated primary parotid gland cancer. ( 25223976 )
2014
9
Robotically assisted selective neck dissection in parotid gland cancer: preliminary report. ( 23208780 )
2013
10
Occurrence of lymph node metastasis in early-stage parotid gland cancer. ( 21671057 )
2012
11
Prognostic value of proliferating cell nuclear antigen in parotid gland cancer. ( 21874325 )
2012
12
Preliminary results of (125)I interstitial brachytherapy for locally recurrent parotid gland cancer in previously irradiated patients. ( 22488812 )
2012
13
Prognostic value of survivin expression in parotid gland cancer in consideration of different histological subtypes. ( 21397494 )
2011
14
An overview of the rare parotid gland cancer. ( 21917153 )
2011
15
Gastrointestinal: isolated colonic metastasis from parotid gland cancer. ( 18699984 )
2008
16
An ileal metastasis from a parotid gland cancer that mimicked a flat adenoma. ( 17285507 )
2007
17
Parotid gland cancer: a case report of a primitive adenocarcinoma arising from a multirecurrent pleomorphic adenoma. ( 15149165 )
2004
18
We present our experience employing magnetic resonance imaging (MRI) for the preoperative assessment of the patients with parotid gland cancer. ( 15366759 )
2004
19
Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas. ( 11251174 )
2001
20
Society of Surgical Oncology Practice Guidelines. Parotid gland cancer surgical practice guidelines. ( 9268982 )
1997
21
Prognostic variables in parotid gland cancer. ( 1747227 )
1991
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Variations for Parotid Gland Cancer

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Expression for Parotid Gland Cancer

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Search GEO for disease gene expression data for Parotid Gland Cancer.
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Pathways for Parotid Gland Cancer

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Pathways related to Parotid Gland Cancer according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Developmental Biology 66
Show member pathways
 13.22 ERBB4 KRT8 KRT83 MET PIK3CA RET
2
Endometrial cancer 37
Show member pathways
 12.67 CDH1 PIK3CA RET SMAD4 SPI1
3
Glioma 37
Show member pathways
 12.54 ALK CDH1 ESR2 MET PIK3CA
4
Development EGFR signaling pathway 22
Show member pathways
 12.35 CDH1 ERBB4 PIK3CA SMAD4
5
Gastric cancer 37
Show member pathways
 12.1 CDH1 CDH17 ESR2 MET PIK3CA SMAD4
6
Pathways in cancer 37
11.95 ALK CDH1 ESR2 MET PIK3CA RET
7
Colorectal Cancer Metastasis 64
11.89 CDH1 MMP14 MMP7 SMAD4
8
Adhesion 4
11.84 CDH1 CDH17 MMP14
9
Tyrosine Kinases / Adaptors 4
11.73 ALK ERBB4 MET RET
10
Bacterial invasion of epithelial cells 37
11.56 CDH1 MET PIK3CA
11
Adherens junction 37
11.53 CDH1 MET SMAD4
12
Central carbon metabolism in cancer 37
11.45 MET PIK3CA RET
13
Cell adhesion_ECM remodeling 22
11.39 ERBB4 MMP14 MMP7
14
FGF signaling pathway 1
11.17 CDH1 MET PIK3CA
15
E-cadherin signaling in keratinocytes 1
10.84 CDH1 PIK3CA
16
a6b1 and a6b4 Integrin signaling 1
10.82 CDH1 MET PIK3CA
17
TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition 1
10.8 CDH1 SMAD4
18
Syndecan-1-mediated signaling events 1
10.77 MET MMP7
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GO Terms for Parotid Gland Cancer

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Cellular components related to Parotid Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.92 ALK ERBB4 MET RET

Biological processes related to Parotid Gland Cancer according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.95 ALK ERBB4 MET PIK3CA RET
2 negative regulation of apoptotic process GO:0043066 9.91 ALK ERBB4 MET NUP62 RET
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 ALK ERBB4 MET RET
4 phosphatidylinositol phosphorylation GO:0046854 9.7 ERBB4 MET PIK3CA
5 peptidyl-tyrosine phosphorylation GO:0018108 9.67 ALK ERBB4 MET RET
6 extracellular matrix disassembly GO:0022617 9.65 CDH1 MMP14 MMP7
7 positive regulation of MAPK cascade GO:0043410 9.62 ALK ERBB4 MET RET
8 somatic stem cell population maintenance GO:0035019 9.58 SMAD4 SPI1 ZIC3
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.56 ALK ERBB4 MET RET
10 entry of bacterium into host cell GO:0035635 9.49 CDH1 MET
11 negative regulation of signal transduction GO:0009968 9.46 ALK ERBB4 MET RET
12 pri-miRNA transcription by RNA polymerase II GO:0061614 9.43 SMAD4 SPI1
13 positive regulation of kinase activity GO:0033674 9.26 ALK ERBB4 MET RET
14 positive regulation of transcription, DNA-templated GO:0045893 9.23 CDH1 ERBB4 ESR2 NUP62 RET SMAD4
15 cell differentiation GO:0030154 10.01 ALK ERBB4 MET RET SPI1 ZIC3

Molecular functions related to Parotid Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.56 ALK ERBB4 MET RET
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 ERBB4 MET RET
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.5 ERBB4 MET PIK3CA
4 MAP kinase kinase kinase activity GO:0004709 9.46 ALK ERBB4 MET RET
5 mitogen-activated protein kinase kinase binding GO:0031434 9.26 ALK ERBB4 MET RET
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 ALK ERBB4 MET RET
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Sources for Parotid Gland Cancer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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