MCID: PRT026
MIFTS: 46

Parotitis

Categories: Endocrine diseases, Oral diseases

Aliases & Classifications for Parotitis

MalaCards integrated aliases for Parotitis:

Name: Parotitis 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10301
MeSH 45 D010309
NCIt 51 C114281
SNOMED-CT 69 14756005
ICD10 34 K11.2
UMLS 74 C0030583

Summaries for Parotitis

Disease Ontology : 12 A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary : Parotitis is related to meningoencephalitis and appendicitis. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are AGE/RAGE pathway and LPA receptor mediated events. The drugs Pyrazinamide and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 meningoencephalitis 30.4 ALB CD79A
2 appendicitis 29.8 ALB MMP9
3 parotitis, juvenile recurrent 12.1
4 lemierre's syndrome 11.5
5 mumps 10.5
6 extracranial arteriovenous malformation 10.3 MMP2 MMP9
7 focal myositis 10.3 MMP2 MMP9
8 villous adenocarcinoma 10.3 MMP2 MMP9
9 spastic entropion 10.3 MMP2 MMP9
10 lentigo maligna melanoma 10.3 MMP2 MMP9
11 psammomatous meningioma 10.3 MMP2 MMP9
12 acute transverse myelitis 10.3 MMP2 MMP9
13 transverse myelitis 10.3 MMP2 MMP9
14 senile ectropion 10.3 MMP2 MMP9
15 internal hemorrhoid 10.3 MMP2 MMP9
16 ischemic colitis 10.2 MMP2 MMP9
17 light chain deposition disease 10.2 MMP2 MMP9
18 conjunctival nevus 10.2 MMP2 MMP9
19 corneal ulcer 10.2 MMP2 MMP9
20 nasal cavity squamous cell carcinoma 10.2 MMP2 MMP9
21 odontogenic myxoma 10.2 MMP2 MMP9
22 orchitis 10.2
23 newcastle disease 10.2 MMP2 MMP9
24 laryngeal disease 10.2 MMP2 MMP9
25 hypertensive heart disease 10.2 MMP2 MMP9
26 influenza 10.2
27 pneumothorax 10.2 MMP2 MMP9
28 aortic aneurysm, familial abdominal, 1 10.2 MMP2 MMP9
29 adenomyosis 10.2 MMP2 MMP9
30 pancreatitis 10.2
31 pancreas disease 10.1 ALB SPINK1
32 grade iii astrocytoma 10.1 MMP2 MMP9
33 chronic graft versus host disease 10.1 ALB CD79A
34 skin melanoma 10.1 MMP2 MMP9
35 focal dermal hypoplasia 10.1 ALB CD79A
36 kernicterus 10.1 ALB G6PD
37 aortic disease 10.1 MMP2 MMP9
38 severe pre-eclampsia 10.1 ALB MMP9
39 sjogren syndrome 10.1
40 pneumonia 10.1
41 protein-losing enteropathy 10.1 ALB CD79A
42 ulcerative stomatitis 10.1 ALB CD79A
43 bacterial meningitis 10.1 ALB MMP9
44 hypersensitivity reaction type iii disease 10.1 ALB CD79A
45 lipoid nephrosis 10.1 ALB CD79A
46 senile cataract 10.1 ALB G6PD
47 varicose veins 10.1 MMP2 MMP9
48 membranoproliferative glomerulonephritis 10.1 ALB CD79A
49 inguinal hernia 10.1 MMP2 MMP9
50 leukemia 10.1

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to Parotitis

Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 CD79A G6PD LTF MMP2 MMP9 SPINK1
2 homeostasis/metabolism MP:0005376 9.56 ALB CD79A G6PD H6PD LTF MMP2
3 neoplasm MP:0002006 9.02 ALB CD79A LTF MMP2 MMP9

Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
2
Rifampicin Approved Phase 4 13292-46-1 5381226 5458213
3
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
4 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1
5 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
7 Antimetabolites Phase 4,Phase 1,Phase 2
8 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
9 Hypolipidemic Agents Phase 4
10 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 1,Phase 2
11 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
12 Cytochrome P-450 CYP3A Inducers Phase 4
13 Antitubercular Agents Phase 4,Phase 1,Phase 2
14 Lipid Regulating Agents Phase 4
15
Tetracycline Approved, Vet_approved Phase 3 60-54-8 5353990
16 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
17
Phenytoin Approved, Vet_approved Phase 1, Phase 2 57-41-0 1775
18
Vidarabine Approved, Investigational Phase 1, Phase 2 24356-66-9 21704 32326
19
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
20
Sargramostim Approved, Investigational Phase 1, Phase 2 123774-72-1, 83869-56-1
21
leucovorin Approved Phase 1, Phase 2 58-05-9 6006 143
22
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
23
Fludarabine Approved Phase 1, Phase 2,Phase 2 75607-67-9, 21679-14-1 30751
24
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
25
Methotrexate Approved Phase 1, Phase 2 1959-05-2, 59-05-2 126941
26
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
27
Calcium Approved, Nutraceutical Phase 1, Phase 2 7440-70-2 271
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
29 Antibodies Phase 1, Phase 2
30 Antimetabolites, Antineoplastic Phase 1, Phase 2
31 Alkylating Agents Phase 1, Phase 2
32 Calcium, Dietary Phase 1, Phase 2
33 Folate Phase 1, Phase 2
34 Vitamin B9 Phase 1, Phase 2
35 Interleukin-2 Phase 1, Phase 2
36 Antifungal Agents Phase 1, Phase 2
37 Dermatologic Agents Phase 1, Phase 2
38 Diuretics, Potassium Sparing Phase 1, Phase 2
39 Cyclosporins Phase 1, Phase 2
40 Mitogens Phase 1, Phase 2
41 Anticonvulsants Phase 1, Phase 2
42 Antirheumatic Agents Phase 1, Phase 2
43 Folic Acid Antagonists Phase 1, Phase 2
44 Calcineurin Inhibitors Phase 1, Phase 2
45 Hormones Phase 1, Phase 2
46 Vitamin B Complex Phase 1, Phase 2
47 Sodium Channel Blockers Phase 1, Phase 2
48 Adjuvants, Immunologic Phase 1, Phase 2
49 Immunosuppressive Agents Phase 1, Phase 2
50 Antineoplastic Agents, Alkylating Phase 1, Phase 2

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Three Regimens to Prevent Tuberculosis in HIV-Infected Patients With Anergy Completed NCT00402610 Phase 4 isoniazid, rifampin + isoniazid, rifampin + pyrazinamide or not treatment
2 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Completed NCT02880865 Phase 4
3 Comparative Study of the Immunogenicity of MMR (Measles, Mumps and Rubella) Single Dose and Multidose Presentations Completed NCT01777529 Phase 4
4 Immunogenicity and Safety of Hepatitis A Vaccine Given at the Same Time of Measles, Mumps, Rubella Combined Vaccine Completed NCT00313950 Phase 4
5 Immunogenicity and Safety of Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00126997 Phase 4
6 Safety & Immunogenicity Study of Meningococcal Vaccine GSK134612 Given With Priorix-Tetra™ to 12-23 Month-Old Children Completed NCT00474266 Phase 3
7 Safety and Immunogenicity Study of Live Attenuated Mumps Vaccines in Healthy Infants Completed NCT02692599 Phase 3
8 Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age Completed NCT02184572 Phase 3
9 Immunogenicity and Safety of GSK Biologicals' Combined Measles-mumps-rubella Vaccine in Volunteers, Seven Years of Age and Older Completed NCT02058563 Phase 3
10 Study of Immunogenicity, Reactogenicity and Safety of the Combined Measles, Mumps and Rubella Vaccine Produced by Bio-Manguinhos/Fiocruz in Children 12-15 Months of Age, Followed by Tetraviral Vaccine in Children 15-18 Months. Completed NCT01991899 Phase 3
11 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life Completed NCT01681992 Phase 3
12 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Subjects Four to Six Years of Age Completed NCT01621802 Phase 3
13 Safety, Tolerability, and Immunogenicity of Measles, Mumps, Rubella, and Varicella (MMRV) Vaccine Made With an Alternative Manufacturing Process (AMP)(V221-027) Completed NCT01536405 Phase 3
14 Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers Completed NCT01188343 Phase 3
15 Comparison of GSK Measles-mumps-rubella-varicella (MMRV) Vaccine Versus PriorixTM Completed NCT00969436 Phase 3
16 Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136 Completed NCT00751348 Phase 3
17 Long-term Follow-up on Immunogenicity & Safety of Measles-Mumps-Rubella-Varicella (MMRV) Combined Vaccine Completed NCT00406211 Phase 3
18 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127023 Phase 3
19 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127010 Phase 3
20 Study to Evaluate Frozen Versus Refrigerated MMRV (Combined Measles, Mumps, Rubella, and Varicella) Investigational Vaccine (V221-016) Completed NCT00092430 Phase 3
21 A Study of An Approved Vaccine at Mumps Expiry Potency in Healthy Children 12 to 18 Months of Age (V205C-007)(COMPLETED) Completed NCT00092391 Phase 3
22 Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Unknown status NCT03133923 Phase 2
23 Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00245037 Phase 1, Phase 2 busulfan;cyclosporine;fludarabine phosphate;mycophenolate mofetil;Granulocyte colony-stimulating factor (G-CSF);Phenytoin;Methotrexate
24 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00353288 Phase 2
25 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00352898 Phase 2
26 A Phase I, Safety Study of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Children Completed NCT01712906 Phase 1
27 Gender and Opioid Consumption Unknown status NCT03006627 Not Applicable postoperative morphine
28 Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome Completed NCT03157011 Not Applicable
29 Serological Study in Children 12 to 23 Months Vaccinated With MMR (Measles, Mumps and Rubella) Completed NCT01874457
30 Making Decisions About the Measles-Mumps-Rubella Vaccine Completed NCT01369394 Not Applicable
31 Measles, Mumps, and Rubella (MMR) Immunity in College Students Completed NCT00962819
32 Safety Study of Measles-Mumps-Rubella-Varicella (MMRV) Vaccine, Priorix-Tetra™ in Children Living in the Philippines Withdrawn NCT01738841

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

Genetic Tests for Parotitis

Anatomical Context for Parotitis

MalaCards organs/tissues related to Parotitis:

42
Salivary Gland, Thyroid, Lung, Brain, Bone, Eye, Bone Marrow

Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 660)
# Title Authors Year
1
Simultaneous parotitis and ipsilateral herpes zoster ophthalmicus: coincidence? ( 30898945 )
2019
2
Parotitis coexisting with Kawasaki disease in a child: a rare presentation of Kawasaki disease. ( 30898051 )
2019
3
Surgical Treatment of Chronic Parotitis. ( 30647789 )
2019
4
The correlation of immunologic derangement and juvenile recurrent parotitis: an investigation of the laboratory immunological observation. ( 30702022 )
2019
5
Juvenile Recurrent Parotitis. ( 30788670 )
2019
6
Could human bocavirus be a causative agent of parotitis in children? ( 29751940 )
2018
7
Mucormycotic parotitis and otitis causing facial nerve palsy in a diabetic patient. ( 29904969 )
2018
8
Non-mumps Viral Parotitis During the 2014-2015 Influenza Season in the United States. ( 29617951 )
2018
9
<i>Mycobacterium mageritense</i> Parotitis in an Immunocompetent Adult. ( 29434394 )
2018
10
Sialendoscopy in treatment of adult chronic recurrent parotitis without sialolithiasis. ( 29290052 )
2018
11
Methicillin-Resistant Staphylococcus aureus Parotitis Leading to Mortality in an Adolescent Male. ( 29939841 )
2018
12
Acute parotitis due to MRSA causing Lemierre's syndrome. ( 29942528 )
2018
13
Influenza-Associated Parotitis During the 2014-2015 Influenza Season in the United States. ( 29617957 )
2018
14
Acute Parotitis after Lower Limb Amputation: A Case Report of a Rare Complication. ( 29736287 )
2018
15
Pediatric Primary Tuberculous Osteomyelitis of the Mandible Mimicking Parotitis. ( 29552433 )
2018
16
Sialoendoscopy for treatment of juvenile recurrent parotitis: The Brescia experience. ( 29447807 )
2018
17
Is Parotitis One More Complication of Influenza? The Ongoing Challenge of Determining Causal Associations. ( 29617960 )
2018
18
Neonatal Parotitis. ( 29428272 )
2018
19
Bruxism-induced parotitis: A retrospective case series analysis. ( 30048228 )
2018
20
Juvenile recurrent parotitis: A systematic review of treatment studies. ( 30055724 )
2018
21
Role of Salivary Duct Morphology in the Etiology of Chronic Obstructive Parotitis: Statistical Analysis of Sialographic Features and Computational Fluid Dynamics Analysis of Salivary Flow. ( 30576669 )
2018
22
Role of sialendoscopy in juvenile recurrent parotitis (JRP). ( 28669808 )
2017
23
Viral etiology of sporadic cases of parotitis among children in Korea during 2013-2014. ( 28876460 )
2017
24
Chronic Recurrent Non-specific Parotitis: A Case Report and Review. ( 28458496 )
2017
25
Sialoendoscopy combined with an internal stent and postoperative massage as a comprehensive treatment of delayed I(131)-induced parotitis. ( 28697989 )
2017
26
Sialendoscopic Approach in Management of Juvenile Recurrent Parotitis. ( 29238673 )
2017
27
Magnetic Resonance Imaging Findings of Mumps Meningoencephalitis with Bilateral Hippocampal Lesions without Preceding Acute Parotitis: A Case Report. ( 28246518 )
2017
28
Parotitis as an Initial Symptom of Kawasaki Disease. ( 28593063 )
2017
29
A case of neuromyelitis optica spectrum disorder (NMOSD) with SjAPgren's syndrome manifested only brain involvement by preceding parotitis. ( 28132975 )
2017
30
Facial and limb angioedema with parotitis and Kikuchi-like necrotizing lymphadenitis preceding neuropsychiatric systemic lupus erythematosus in a young African American male. ( 28849689 )
2017
31
Core curriculum illustration: pediatric viral parotitis. ( 28593330 )
2017
32
Chymotrypsin with sialendoscopy-assisted surgery for the treatment of chronic obstructive parotitis. ( 28279602 )
2017
33
Ultrasound elastography in diagnosis and follow-up for patients with chronic recurrent parotitis. ( 28885206 )
2017
34
An unusual case of acute parotitis in a young adult. ( 28742741 )
2017
35
Development of acute parotitis after non-invasive ventilation. ( 28840025 )
2017
36
Challenging Case of Parotitis: A Comprehensive Approach. ( 29181524 )
2017
37
Erratum to: Pediatric suppurative parotitis caused by Burkholderia pseudomallei. ( 28138332 )
2017
38
Role of the Accessory Parotid Gland in the Etiology of Parotitis: Statistical Analysis of Sialographic Features. ( 26913509 )
2016
39
Concomitant Suppurative Parotitis and Condylar Osteomyelitis. ( 27717819 )
2016
40
Eosinophilic sialodochitis: redefinition of 'allergic parotitis' and 'sialodochitis fibrinosa'. ( 27748012 )
2016
41
Acute Parotitis as a Complication of Noninvasive Ventilation. ( 26928643 )
2016
42
Streptococcus pneumoniae bacteraemia due to parotitis in a patient with systemic sclerosis and secondary SjAPgren's syndrome. ( 28348790 )
2016
43
Bilateral parotitis in a patient under continuous positive airway pressure treatment. ( 27793244 )
2016
44
Diagnosing Juvenile Recurrent Parotitis. Case Reports. ( 26939156 )
2016
45
Tuberculous Lymphadenitis and Parotitis. ( 28084205 )
2016
46
Parotitis and Sialendoscopy of the Parotid Gland. ( 26912292 )
2016
47
Sialendoscopic treatment of recurrent juvenile parotitis: A South African case series. ( 27499410 )
2016
48
Function of the parotid gland in juvenile recurrent parotitis: a case series. ( 26852271 )
2016
49
Presentation of acute suppurative parotitis in a newborn with incessant crying. ( 27986789 )
2016
50
Neonatal Suppurative Parotitis: Two Cases. ( 27351362 )
2016

Variations for Parotitis

Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for Parotitis

GO Terms for Parotitis

Cellular components related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.55 ALB G6PD LTF MMP9 SPINK1
2 extracellular space GO:0005615 9.02 ALB LTF MMP2 MMP9 SPINK1
3 tertiary granule lumen GO:1904724 8.96 LTF MMP9

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose metabolic process GO:0006006 9.48 G6PD H6PD
2 extracellular matrix disassembly GO:0022617 9.46 MMP2 MMP9
3 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.43 MMP2 MMP9
4 embryo implantation GO:0007566 9.4 MMP2 MMP9
5 retina homeostasis GO:0001895 9.37 ALB LTF
6 cellular protein metabolic process GO:0044267 9.33 ALB LTF MMP2
7 collagen catabolic process GO:0030574 9.32 MMP2 MMP9
8 endodermal cell differentiation GO:0035987 9.26 MMP2 MMP9
9 pentose-phosphate shunt GO:0006098 8.96 G6PD H6PD
10 NADP metabolic process GO:0006739 8.62 G6PD H6PD

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.16 G6PD H6PD
2 serine-type endopeptidase activity GO:0004252 9.13 LTF MMP2 MMP9
3 glucose-6-phosphate dehydrogenase activity GO:0004345 8.62 G6PD H6PD

Sources for Parotitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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