Parotitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Parotitis is related to meningitis and sjogren syndrome. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor Kazal Type 1), and among its related pathways/superpathways are Innate Immune System and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone marrow and pancreas, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia: ⁷⁵ Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

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Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 666)

#	Related Disease	Score	Top Affiliating Genes
1	meningitis	31.0	MMP9 CRP ALB
2	sjogren syndrome	30.6	TRIM21 SSB LTF CD79A
3	orchitis	30.6	CRP CD8A CD4
4	kawasaki disease	30.5	MMP9 MMP2 CRP
5	bell's palsy	30.4	CRP CD8A CD4 ALB
6	reactive arthritis	30.3	LTF CRP CD79A
7	facial paralysis	30.3	CRP CD8A CD4 ALB
8	immunoglobulin alpha deficiency	30.2	CD8A CD79A CD4
9	chickenpox	30.2	CRP CD8A CD4 ALB
10	meningoencephalitis	30.2	CRP CD8A CD79A CD4 ALB
11	cervical adenitis	30.2	CRP CD4
12	sialadenitis	30.1	TRIM21 SSB MMP2 CD4 BPIFA2
13	acquired immunodeficiency syndrome	30.1	CRP CD79A CD4 ALB
14	mediastinitis	30.0	CRP CD4 ALB
15	scarlet fever	30.0	CRP CD4 ALB
16	keratoconjunctivitis	30.0	TRIM21 LTF ALB
17	mesenteric lymphadenitis	30.0	CRP ALB
18	cellulitis	29.9	CRP CD8A CD4 ALB
19	paralytic ileus	29.9	CRP ALB
20	severe cutaneous adverse reaction	29.9	CRP CD8A CD4
21	decubitus ulcer	29.9	MMP9 CRP ALB
22	disease by infectious agent	29.9	CRP CD8A CD4 ALB
23	appendicitis	29.9	MMP9 CRP ALB
24	aseptic meningitis	29.8	CRP CD8A CD4 ALB
25	amebiasis	29.8	CD79A CD4 ALB
26	hepatitis a	29.8	G6PD CD4 ALB
27	actinomycosis	29.8	CRP CD4 ALB
28	autoimmune pancreatitis	29.8	SPINK1 CRP CD4
29	acute myocarditis	29.8	CRP CD8A CD4
30	septic arthritis	29.8	CRP CD4 ALB
31	alcohol use disorder	29.7	CRP CD4 ALB
32	pfeiffer syndrome	29.7	CRP CD8A CD4
33	bronchitis	29.6	MMP9 LTF CRP ALB
34	dengue disease	29.6	CD8A CD4 ALB
35	exanthem	29.6	TRIM21 CRP CD8A CD4 ALB
36	secondary syphilis	29.6	CRP CD8A CD4
37	oral candidiasis	29.6	LTF CD8A CD4
38	iridocyclitis	29.6	CRP CD8A CD4
39	dysentery	29.5	LTF CRP CD4 ALB
40	anterior uveitis	29.5	CRP CD8A CD4
41	celiac disease 1	29.5	CRP CD8A CD79A CD4 ALB
42	pharyngitis	29.5	CRP CD8A CD4
43	panniculitis	29.5	CRP CD8A CD4
44	mikulicz disease	29.5	TRIM21 SSB SPINK1 CRP CD4
45	syphilis	29.4	CRP CD8A CD79A CD4 ALB
46	miliary tuberculosis	29.4	CRP CD8A CD4 ALB
47	extrapulmonary tuberculosis	29.4	CRP CD8A CD4 ALB
48	pneumocystosis	29.4	CRP CD8A CD4 ALB
49	herpangina	29.4	CRP CD8A CD4 ALB
50	viral meningitis	29.4	CRP CD8A CD4 ALB

Graphical network of the top 20 diseases related to Parotitis:

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Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.07	ALB CD4 CD79A CMAS CRP G6PD
2	immune system	MP:0005387	10	ALB CD4 CD79A CD8A CMAS CRP
3	hematopoietic system	MP:0005397	9.7	CD4 CD79A CD8A G6PD KLK4 LTF
4	mortality/aging	MP:0010768	9.44	ALB CD4 CD79A CD8A CMAS G6PD

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Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Vaccines

Phase 2, Phase 3

2

Immunologic Factors

Phase 2, Phase 3

3

Morphine

Approved, Investigational

57-27-2

5288826

4

Narcotics

5

Analgesics, Opioid

6

Analgesics

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase II/III of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Healthy Children Aged 5-11	Unknown status	NCT04591405	Phase 2, Phase 3
2	Safety and Efficacy of Attenuated Mumps Vaccine (Human Diploid Cell)	Unknown status	NCT03133923	Phase 2
3	Gender and Opioid Consumption	Unknown status	NCT03006627		postoperative morphine
4	Treatment of Juvenile Recurrent Parotitis: the Yield of Minimally Invasive Intervention, a Prospective Controlled Study	Not yet recruiting	NCT04074694

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

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Genetic Tests for Parotitis

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Anatomical Context for Parotitis

Organs/tissues related to Parotitis:

MalaCards : Salivary Gland, Bone Marrow, Pancreas, Lymph Node, Bone, Adrenal Cortex, Small Intestine

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Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 2253)

#	Title	Authors	PMID	Year
1	New insights into juvenile parotitis. ⁵³ ⁶²	Kolho KL...Pitkaranta A	16303695	2005
2	Chronic parotitis: not another SPINKosis. ⁵³ ⁶²	Gundling F...Teich N	15753612	2004
3	Polymicrobial Acute Suppurative Parotitis in a 33-Day-Old Infant: A Case Report and Review of the Literature. ⁶²	Paouris D...Pitiriga V	35678072	2022
4	Nodular Oncocytic Hyperplasia of Bilateral Parotid Glands With Parapharyngeal Space Extension. ⁶²	Hung CJ...Liao JB	33215532	2022
5	Bilateral parotid gland swelling: An unusual presentation of B cell lymphoma. ⁶²	Mathe S...Mate J	36165545	2022
6	Late-onset recurrence of neonatal Group B Streptococcus disease presenting with acute parotitis. ⁶²	Al Abdali K...Isaacs D	35536046	2022
7	COVID-19 Associated Parotitis in a 4-Year-Old Boy. ⁶²	Likitnukul S	36004746	2022
8	Epstein-Barr virus-associated acute pancreatitis: a clinical report and review of literature. ⁶²	Accomando S...Giuffre M	36064422	2022
9	Pediatric rheumatologists' perspectives on diagnosis, treatment, and outcomes of Sjögren disease in children and adolescents. ⁶²	Randell RL...CARRA Investigators	36064423	2022
10	Cytology as a rapid tool in diagnosing tuberculosis of the parotid gland: A case series with a review of the literature. ⁶²	Kamal N...Singh M	35924792	2022
11	Management and control issues related to two mumps outbreaks in Houston: Future implications. ⁶²	Schulte J...Persse D	35959718	2022
12	Do Not Ignore Tuberculosis of the Parotid Gland When Meeting Obvious Infiltration of Neutrophils in a Suspicious Swelling by FNAC. ⁶²	Yang F...Ge Y	32998533	2022
13	Neonatal venolymphatic malformation with spontaneous parotid duct rupture: first case report. ⁶²	Gamage DCT...Olabi A	35769188	2022
14	Role of Sialendoscopy in Non-neoplastic Parotid Diseases: A Prospective Study of 241 Patients in Indian Population. ⁶²	Goyal M...Batra A	35712411	2022
15	Differences between radioactive iodine-induced sialadenitis and chronic obstructive parotitis. ⁶²	Li X...Yu GY	34776313	2022
16	Parotitis caused by Mycobacteroides abscessus subspecies abscessus. ⁶²	Yonekawa A...Shimono N	33246745	2022
17	Acute bilateral suppurative parotitis following treatment of acute decompensated heart failure with noninvasive positive-pressure ventilation. ⁶²	Yasuoka K...Yamanouchi T	35769180	2022
18	Unusual complications of non-invasive mechanical ventilation (NIV) and high-flow nasal cannula (HFNC): A systematic review. ⁶²	Lazovic B...Zack S	35785884	2022
19	Static Suspension of the Paralyzed Face Utilizing the Midfacial Corridor: Anatomic Evaluation and Surgical Technique. ⁶²	Klebuc MJ...Doval AF	34425593	2022
20	Is seminal quality worsening? A 20-year experience in Córdoba, Argentina. ⁶²	Ramirez ND...Martini AC	35296953	2022
21	Postoperative infection of the skull base surgical site due to suppurative parotitis: A case report. ⁶²	Zhao Y...Feng GD	35801038	2022
22	Profile analysis of adverse events after boron neutron capture therapy for head and neck cancer: a sub-analysis of the JHN002 study. ⁶²	Hirose K...Takai Y	35388879	2022
23	The applicability of ultrasound in the diagnosis of inflammatory and obstructive diseases of the major salivary glands: a scoping review. ⁶²	Resende EA...Aguiar MCF	34762496	2022
24	Parotid irrigation: A promising option for juvenile recurrent parotitis. ⁶²	Grande-Moreillo C...Rodriguez-Molinero A	35256205	2022
25	Childhood esophageal achalasia: Case report from Afghanistan with literature review. ⁶²	Hakimi T...Karimi R	35658288	2022
26	Purulent Discharge from Stensen Duct in Neonatal Suppurative Parotitis. ⁶²	Ichinose M...Hataya H	34952006	2022
27	Acute parotitis as a presentation of COVID-19? ⁶²	Riad A...Klugar M	32713097	2022
28	Updates in childhood Sjogren's syndrome. ⁶²	Wright TB	34879027	2022
29	Acute suppurative parotitis caused by foreign body in parotid duct: a case report and literature review. ⁶²	Yang Q...Zheng W	35332755	2022
30	A Retrospective Analysis of Multiple Affected Salivary Gland Diseases: Diagnostic and Therapeutic Benefits of Interventional Sialendoscopy. ⁶²	Borner U...Remacle M	35324340	2022
31	Cost analysis of sialendoscopy for the treatment of salivary gland disorders in children. ⁶²	Velasquez N...Stapleton A	34973523	2022
32	Mumps Infection With Symptoms of Parotitis, Pancreatitis, and Orchitis Concurrently in an Adolescent Male. ⁶²	Garg T...Rajesh R	35282503	2022
33	Novel Multidisciplinary Salivary Gland Society (MSGS) Questionnaire: An International Consensus. ⁶²	Buchholzer S...Marchal F	34236085	2022
34	Common Characteristics and Clinical Management Recommendations for Juvenile Recurrent Parotitis: A 10-Year Tertiary Center Experience. ⁶²	Benaim E...McLevy-Bazzanella J	35187385	2022
35	Hypocomplementemia in Primary Sjogren's Syndrome: A Retrospective Study of 120 Treatment-Naive Chinese Patients. ⁶²	Zhou M...Yuan F	35035231	2022
36	Acute Suppurative Parotitis Following Acute Ischemic Stroke: A Case Report. ⁶²	Komagamine J...Osawa H	35223274	2022
37	Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity. ⁶²	Asyraf PA...Abdulah R	35903308	2022
38	Treatment of juvenile recurrent parotitis with irrigation therapy without anesthesia. ⁶²	Geisthoff UW...Hoch S	34117898	2022
39	Neonatal suppurative parotitis: Case reports and literature review. ⁶²	Mori T...Fuse S	33955624	2022
40	Treatment Strategy for Chronic Obstructive Parotitis Related to Diabetes: A Retrospective Analysis of 12 Cases. ⁶²	Wu CB...Zhou Q	35847021	2022
41	Unilateral parotitis following mRNA coronavirus disease 2019 vaccination. ⁶²	Bekci T...Aslan S	35522802	2022
42	Long-term outcome of a cohort of 272 patients undergoing sialendoscopy. ⁶²	Vanden Daele A...Vander Poorten V	34674373	2022
43	Infantile Parotid Hemangioma With Diagnostic Dilemma: A Case Report. ⁶²	Abidi KT...Alalyani SA	35095285	2022
44	Pediatricians' Knowledge and Practices Related to Mumps Diagnosis and Prevention. ⁶²	Cataldi JR...Kempe A	34453916	2021
45	Mumps in Vaccinated Children and Adolescents: 2007-2019. ⁶²	Shepersky L...Marlow MA	34814181	2021
46	IgG4-related chronic sclerosing sialadenitis in a child with recurrent parotitis: a case report. ⁶²	Timeus F...Vittone F	34930210	2021
47	Oral Manifestations in Patients with COVID-19: A 6-Month Update. ⁶²	Amorim Dos Santos J...Guerra ENS	34324825	2021
48	Unique Aspects of Pediatric Sjögren Disease. ⁶²	Randell RL...Lieberman SM	34635300	2021
49	A Presentation of Pediatric Sjögren's Syndrome with Abducens Nerve Palsy. ⁶²	Lin J...Gombolay G	33316834	2021
50	Immune disorders associated with juvenile recurrent chronic parotitis. ⁶²	Hidalgo-Santos AD...Oltra-Benavent M	34518129	2021

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Genes for Parotitis

Genes related to Parotitis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	SPINK1	Serine Peptidase Inhibitor Kazal Type 1	Protein Coding	17.45	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15753612 16303695
2	ALB	Albumin	Protein Coding	11.86	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	MMP9	Matrix Metallopeptidase 9	Protein Coding	10.83	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	MMP2	Matrix Metallopeptidase 2	Protein Coding	10.62	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	CD79A	CD79a Molecule	Protein Coding	7.52	GeneCards inferred via : Publications (show sections)
6	G6PD	Glucose-6-Phosphate Dehydrogenase	Protein Coding	7.52	GeneCards inferred via : Publications (show sections)
7	H6PD	Hexose-6-Phosphate Dehydrogenase/Glucose 1-Dehydrogenase	Protein Coding	7.52	GeneCards inferred via : Publications (show sections)
8	LTF	Lactotransferrin	Protein Coding	7.52	GeneCards inferred via : Publications (show sections)
9	CRP	C-Reactive Protein	Protein Coding	5.73	DISEASES inferred ¹⁴
10	CD4	CD4 Molecule	Protein Coding	5.46	DISEASES inferred ¹⁴
11	SSB	Small RNA Binding Exonuclease Protection Factor La	Protein Coding	5.39	DISEASES inferred ¹⁴
12	TRIM21	Tripartite Motif Containing 21	Protein Coding	5.33	DISEASES inferred ¹⁴
13	KLK4	Kallikrein Related Peptidase 4	Protein Coding	5.3	DISEASES inferred ¹⁴
14	BPIFA2	BPI Fold Containing Family A Member 2	Protein Coding	5.27	DISEASES inferred ¹⁴
15	CMAS	Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase	Protein Coding	5.25	DISEASES inferred ¹⁴
16	CD8A	CD8a Molecule	Protein Coding	5.06	DISEASES inferred ¹⁴

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Variations for Parotitis

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Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

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Pathways for Parotitis

Pathways related to Parotitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.46	TRIM21 MMP9 MMP2 LTF CRP CD8A
2	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.56	CD8A CD79A CD4
3	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.02	CRP CD8A CD4
4	Male infertility ⁷⁴	10.52	MMP9 MMP2 LTF
5	"Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics" ⁶⁰ Show member pathways GDP-mannose biosynthesis ⁶¹ pentose phosphate pathway (oxidative branch) ⁶¹ pentose phosphate pathway (oxidative branch) I ⁶¹	10.3	H6PD G6PD

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GO Terms for Parotitis

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix disassembly	GO:0022617	9.43	MMP9 MMP2 KLK4
2	pentose-phosphate shunt, oxidative branch	GO:0009051	8.92	H6PD G6PD

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase activity	GO:0004252	9.76	MMP9 MMP2 LTF KLK4
2	oxidoreductase activity, acting on CH-OH group of donors	GO:0016614	8.96	H6PD G6PD
3	glucose-6-phosphate dehydrogenase activity	GO:0004345	8.92	H6PD G6PD

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Sources for Parotitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 24-Oct-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: PRT026 MIFTS: 40	Parotitis Categories: Endocrine diseases, Oral diseases	Data Licensing For inquiries, contact: [email protected]
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