MCID: PRT026
MIFTS: 46

Parotitis

Categories: Endocrine diseases, Oral diseases

Aliases & Classifications for Parotitis

MalaCards integrated aliases for Parotitis:

Name: Parotitis 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10301
MeSH 45 D010309
NCIt 51 C114281
SNOMED-CT 69 14756005
ICD10 34 K11.2
UMLS 74 C0030583

Summaries for Parotitis

Disease Ontology : 12 A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary : Parotitis is related to meningoencephalitis and appendicitis. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are AGE/RAGE pathway and LPA receptor mediated events. The drugs Isoniazid and Pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 meningoencephalitis 30.1 ALB CD79A
2 appendicitis 29.8 ALB MMP9
3 parotitis, juvenile recurrent 12.1
4 lemierre's syndrome 11.5
5 mumps 10.5
6 extracranial arteriovenous malformation 10.3 MMP2 MMP9
7 focal myositis 10.3 MMP2 MMP9
8 villous adenocarcinoma 10.3 MMP2 MMP9
9 sjogren syndrome 10.3
10 facial paralysis 10.3
11 spastic entropion 10.3 MMP2 MMP9
12 lentigo maligna melanoma 10.3 MMP2 MMP9
13 psammomatous meningioma 10.3 MMP2 MMP9
14 acute transverse myelitis 10.3 MMP2 MMP9
15 transverse myelitis 10.3 MMP2 MMP9
16 senile ectropion 10.3 MMP2 MMP9
17 internal hemorrhoid 10.3 MMP2 MMP9
18 ischemic colitis 10.3 MMP2 MMP9
19 light chain deposition disease 10.2 MMP2 MMP9
20 conjunctival nevus 10.2 MMP2 MMP9
21 orchitis 10.2
22 corneal ulcer 10.2 MMP2 MMP9
23 nasal cavity squamous cell carcinoma 10.2 MMP2 MMP9
24 odontogenic myxoma 10.2 MMP2 MMP9
25 newcastle disease 10.2 MMP2 MMP9
26 laryngeal disease 10.2 MMP2 MMP9
27 influenza 10.2
28 hypertensive heart disease 10.2 MMP2 MMP9
29 pneumothorax 10.2 MMP2 MMP9
30 aortic aneurysm, familial abdominal, 1 10.2 MMP2 MMP9
31 adenomyosis 10.2 MMP2 MMP9
32 pancreatitis 10.2
33 pancreas disease 10.2 ALB SPINK1
34 grade iii astrocytoma 10.1 MMP2 MMP9
35 skin melanoma 10.1 MMP2 MMP9
36 pneumonia 10.1
37 aortic disease 10.1 MMP2 MMP9
38 severe pre-eclampsia 10.1 ALB MMP9
39 bacterial meningitis 10.1 ALB MMP9
40 dysentery 10.1 ALB LTF
41 varicose veins 10.1 MMP2 MMP9
42 leukemia 10.1
43 sialadenitis 10.1
44 lymphadenitis 10.1
45 meningitis 10.1
46 inguinal hernia 10.1 MMP2 MMP9
47 kernicterus 10.1 ALB G6PD
48 gingivitis 10.1 LTF MMP9
49 mastitis 10.1 ALB LTF
50 senile cataract 10.1 ALB G6PD

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to Parotitis

Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 CD79A G6PD LTF MMP2 MMP9 SPINK1
2 homeostasis/metabolism MP:0005376 9.56 ALB CD79A G6PD H6PD LTF MMP2
3 neoplasm MP:0002006 9.02 ALB CD79A LTF MMP2 MMP9

Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
2
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
3
Rifampicin Approved Phase 4 13292-46-1 5381226 5458213
4 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1
5 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
7 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
8 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
9 Lipid Regulating Agents Phase 4
10 Hypolipidemic Agents Phase 4
11 Antimetabolites Phase 4,Phase 1,Phase 2
12 Cytochrome P-450 CYP3A Inducers Phase 4
13 Antitubercular Agents Phase 4,Phase 1,Phase 2
14 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 1,Phase 2
15
Tetracycline Approved, Vet_approved Phase 3 60-54-8 5353990
16 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
17
Phenytoin Approved, Vet_approved Phase 1, Phase 2 57-41-0 1775
18
leucovorin Approved Phase 1, Phase 2 58-05-9 143 6006
19
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
20
Methotrexate Approved Phase 1, Phase 2 1959-05-2, 59-05-2 126941
21
Fludarabine Approved Phase 1, Phase 2,Phase 2 75607-67-9, 21679-14-1 30751
22
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
23
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
24
Sargramostim Approved, Investigational Phase 1, Phase 2 123774-72-1, 83869-56-1
25
Vidarabine Approved, Investigational Phase 1, Phase 2 24356-66-9 21704 32326
26
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
28
Calcium Approved, Nutraceutical Phase 1, Phase 2 7440-70-2 271
29 Antibodies Phase 1, Phase 2
30 Interleukin-4 Phase 1, Phase 2
31 Antiviral Agents Phase 1, Phase 2
32 Vitamin B Complex Phase 1, Phase 2
33 Folic Acid Antagonists Phase 1, Phase 2
34 Antirheumatic Agents Phase 1, Phase 2
35 Immunoglobulins Phase 1, Phase 2
36 Adjuvants, Immunologic Phase 1, Phase 2
37 polysaccharide-K Phase 1, Phase 2
38 Alkylating Agents Phase 1, Phase 2
39 Anticonvulsants Phase 1, Phase 2
40 Dermatologic Agents Phase 1, Phase 2
41 Antifungal Agents Phase 1, Phase 2
42 Antimetabolites, Antineoplastic Phase 1, Phase 2
43 Hormones Phase 1, Phase 2
44 Antineoplastic Agents, Alkylating Phase 1, Phase 2
45 Calcium, Dietary Phase 1, Phase 2
46 Folate Phase 1, Phase 2
47 Mitogens Phase 1, Phase 2
48 Diuretics, Potassium Sparing Phase 1, Phase 2
49 Immunosuppressive Agents Phase 1, Phase 2
50 Calcineurin Inhibitors Phase 1, Phase 2

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Three Regimens to Prevent Tuberculosis in HIV-Infected Patients With Anergy Completed NCT00402610 Phase 4 isoniazid, rifampin + isoniazid, rifampin + pyrazinamide or not treatment
2 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Completed NCT02880865 Phase 4
3 Comparative Study of the Immunogenicity of MMR (Measles, Mumps and Rubella) Single Dose and Multidose Presentations Completed NCT01777529 Phase 4
4 Immunogenicity and Safety of Hepatitis A Vaccine Given at the Same Time of Measles, Mumps, Rubella Combined Vaccine Completed NCT00313950 Phase 4
5 Immunogenicity and Safety of Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00126997 Phase 4
6 Safety & Immunogenicity Study of Meningococcal Vaccine GSK134612 Given With Priorix-Tetra™ to 12-23 Month-Old Children Completed NCT00474266 Phase 3
7 Safety and Immunogenicity Study of Live Attenuated Mumps Vaccines in Healthy Infants Completed NCT02692599 Phase 3
8 Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age Completed NCT02184572 Phase 3
9 Immunogenicity and Safety of GSK Biologicals' Combined Measles-mumps-rubella Vaccine in Volunteers, Seven Years of Age and Older Completed NCT02058563 Phase 3
10 Study of Immunogenicity, Reactogenicity and Safety of the Combined Measles, Mumps and Rubella Vaccine Produced by Bio-Manguinhos/Fiocruz in Children 12-15 Months of Age, Followed by Tetraviral Vaccine in Children 15-18 Months. Completed NCT01991899 Phase 3
11 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life Completed NCT01681992 Phase 3
12 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Subjects Four to Six Years of Age Completed NCT01621802 Phase 3
13 Safety, Tolerability, and Immunogenicity of Measles, Mumps, Rubella, and Varicella (MMRV) Vaccine Made With an Alternative Manufacturing Process (AMP)(V221-027) Completed NCT01536405 Phase 3
14 Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers Completed NCT01188343 Phase 3
15 Comparison of GSK Measles-mumps-rubella-varicella (MMRV) Vaccine Versus PriorixTM Completed NCT00969436 Phase 3
16 Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136 Completed NCT00751348 Phase 3
17 Long-term Follow-up on Immunogenicity & Safety of Measles-Mumps-Rubella-Varicella (MMRV) Combined Vaccine Completed NCT00406211 Phase 3
18 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127023 Phase 3
19 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127010 Phase 3
20 Study to Evaluate Frozen Versus Refrigerated MMRV (Combined Measles, Mumps, Rubella, and Varicella) Investigational Vaccine (V221-016) Completed NCT00092430 Phase 3
21 A Study of An Approved Vaccine at Mumps Expiry Potency in Healthy Children 12 to 18 Months of Age (V205C-007)(COMPLETED) Completed NCT00092391 Phase 3
22 Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Unknown status NCT03133923 Phase 2
23 Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00245037 Phase 1, Phase 2 busulfan;cyclosporine;fludarabine phosphate;mycophenolate mofetil;Granulocyte colony-stimulating factor (G-CSF);Phenytoin;Methotrexate
24 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00353288 Phase 2
25 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00352898 Phase 2
26 A Phase I, Safety Study of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Children Completed NCT01712906 Phase 1
27 Gender and Opioid Consumption Unknown status NCT03006627 Not Applicable postoperative morphine
28 Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome Completed NCT03157011 Not Applicable
29 Serological Study in Children 12 to 23 Months Vaccinated With MMR (Measles, Mumps and Rubella) Completed NCT01874457
30 Making Decisions About the Measles-Mumps-Rubella Vaccine Completed NCT01369394 Not Applicable
31 Measles, Mumps, and Rubella (MMR) Immunity in College Students Completed NCT00962819
32 Safety Study of Measles-Mumps-Rubella-Varicella (MMRV) Vaccine, Priorix-Tetra™ in Children Living in the Philippines Withdrawn NCT01738841

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

Genetic Tests for Parotitis

Anatomical Context for Parotitis

MalaCards organs/tissues related to Parotitis:

42
Salivary Gland, Thyroid, Bone, Myeloid, Brain, Eye, Bone Marrow

Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 661)
# Title Authors Year
1
Juvenile Recurrent Parotitis. ( 30788670 )
2019
2
Surgical Treatment of Chronic Parotitis. ( 30647789 )
2019
3
Could human bocavirus be a causative agent of parotitis in children? ( 29751940 )
2019
4
Parotitis coexisting with Kawasaki disease in a child: a rare presentation of Kawasaki disease. ( 30898051 )
2019
5
Simultaneous parotitis and ipsilateral herpes zoster ophthalmicus: coincidence? ( 30898945 )
2019
6
Facial and limb angioedema with parotitis and Kikuchi-like necrotizing lymphadenitis preceding neuropsychiatric systemic lupus erythematosus in a young African American male. ( 28849689 )
2018
7
Non-mumps Viral Parotitis During the 2014-2015 Influenza Season in the United States. ( 29617951 )
2018
8
Pediatric Primary Tuberculous Osteomyelitis of the Mandible Mimicking Parotitis. ( 29552433 )
2018
9
The correlation of immunologic derangement and juvenile recurrent parotitis: an investigation of the laboratory immunological observation. ( 30702022 )
2018
10
Role of Salivary Duct Morphology in the Etiology of Chronic Obstructive Parotitis: Statistical Analysis of Sialographic Features and Computational Fluid Dynamics Analysis of Salivary Flow. ( 30576669 )
2018
11
Juvenile recurrent parotitis: A systematic review of treatment studies. ( 30055724 )
2018
12
Methicillin-Resistant Staphylococcus aureus Parotitis Leading to Mortality in an Adolescent Male. ( 29939841 )
2018
13
Mucormycotic parotitis and otitis causing facial nerve palsy in a diabetic patient. ( 29904969 )
2018
14
Acute Parotitis after Lower Limb Amputation: A Case Report of a Rare Complication. ( 29736287 )
2018
15
Is Parotitis One More Complication of Influenza? The Ongoing Challenge of Determining Causal Associations. ( 29617960 )
2018
16
Influenza-Associated Parotitis During the 2014-2015 Influenza Season in the United States. ( 29617957 )
2018
17
Sialoendoscopy for treatment of juvenile recurrent parotitis: The Brescia experience. ( 29447807 )
2018
18
Mycobacterium mageritense Parotitis in an Immunocompetent Adult. ( 29434394 )
2018
19
Neonatal Parotitis. ( 29428272 )
2018
20
Sialendoscopy in treatment of adult chronic recurrent parotitis without sialolithiasis. ( 29290052 )
2018
21
Viral etiology of sporadic cases of parotitis among children in Korea during 2013-2014. ( 28876460 )
2018
22
Acute parotitis due to MRSA causing Lemierre's syndrome. ( 29942528 )
2018
23
Bruxism-induced parotitis: A retrospective case series analysis. ( 30048228 )
2018
24
Magnetic Resonance Imaging Findings of Mumps Meningoencephalitis with Bilateral Hippocampal Lesions without Preceding Acute Parotitis: A Case Report. ( 28246518 )
2017
25
Concomitant Suppurative Parotitis and Condylar Osteomyelitis. ( 27717819 )
2017
26
Eosinophilic sialodochitis: redefinition of 'allergic parotitis' and 'sialodochitis fibrinosa'. ( 27748012 )
2017
27
Sialendoscopic Approach in Management of Juvenile Recurrent Parotitis. ( 29238673 )
2017
28
Challenging Case of Parotitis: A Comprehensive Approach. ( 29181524 )
2017
29
Ultrasound elastography in diagnosis and follow-up for patients with chronic recurrent parotitis. ( 28885206 )
2017
30
Development of acute parotitis after non-invasive ventilation. ( 28840025 )
2017
31
An unusual case of acute parotitis in a young adult. ( 28742741 )
2017
32
Sialoendoscopy combined with an internal stent and postoperative massage as a comprehensive treatment of delayed I131-induced parotitis. ( 28697989 )
2017
33
Role of sialendoscopy in juvenile recurrent parotitis (JRP). ( 28669808 )
2017
34
Core curriculum illustration: pediatric viral parotitis. ( 28593330 )
2017
35
Chronic Recurrent Non-specific Parotitis: A Case Report and Review. ( 28458496 )
2017
36
Chymotrypsin with sialendoscopy-assisted surgery for the treatment of chronic obstructive parotitis. ( 28279602 )
2017
37
Erratum to: Pediatric suppurative parotitis caused by Burkholderia pseudomallei. ( 28138332 )
2017
38
Sialendoscopy-assisted treatment for chronic obstructive parotitis related to Sjogren syndrome. ( 28049607 )
2017
39
Presentation of acute suppurative parotitis in a newborn with incessant crying. ( 27986789 )
2017
40
Chronic parotitis with multiple calcifications: Clinical and sialendoscopic findings. ( 27861944 )
2017
41
Parotitis as an Initial Symptom of Kawasaki Disease. ( 28593063 )
2017
42
A case of neuromyelitis optica spectrum disorder (NMOSD) with Sjögren's syndrome manifested only brain involvement by preceding parotitis. ( 28132975 )
2017
43
Complete genome sequence of mumps viruses isolated from patients with parotitis, pancreatitis and encephalitis in India. ( 26876221 )
2016
44
A case of a male presenting with fever, parotitis, epididymo-orchitis, and kidney injury. ( 27012169 )
2016
45
Tuberculous Lymphadenitis and Parotitis. ( 28084205 )
2016
46
Sialendoscopic treatment of recurrent juvenile parotitis: A South African case series. ( 27499410 )
2016
47
Botulinum Toxin for the Management of Sjögren Syndrome-Associated Recurrent Parotitis. ( 27400144 )
2016
48
Neonatal Suppurative Parotitis: Two Cases. ( 27351362 )
2016
49
Diagnosing Juvenile Recurrent Parotitis. Case Reports. ( 26939156 )
2016
50
Acute Parotitis as a Complication of Noninvasive Ventilation. ( 26928643 )
2016

Variations for Parotitis

Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for Parotitis

GO Terms for Parotitis

Cellular components related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.55 ALB G6PD LTF MMP9 SPINK1
2 extracellular space GO:0005615 9.02 ALB LTF MMP2 MMP9 SPINK1
3 tertiary granule lumen GO:1904724 8.96 LTF MMP9

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose metabolic process GO:0006006 9.48 G6PD H6PD
2 extracellular matrix disassembly GO:0022617 9.46 MMP2 MMP9
3 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.43 MMP2 MMP9
4 embryo implantation GO:0007566 9.4 MMP2 MMP9
5 retina homeostasis GO:0001895 9.37 ALB LTF
6 cellular protein metabolic process GO:0044267 9.33 ALB LTF MMP2
7 collagen catabolic process GO:0030574 9.32 MMP2 MMP9
8 endodermal cell differentiation GO:0035987 9.26 MMP2 MMP9
9 pentose-phosphate shunt GO:0006098 8.96 G6PD H6PD
10 NADP metabolic process GO:0006739 8.62 G6PD H6PD

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.16 G6PD H6PD
2 serine-type endopeptidase activity GO:0004252 9.13 LTF MMP2 MMP9
3 glucose-6-phosphate dehydrogenase activity GO:0004345 8.62 G6PD H6PD

Sources for Parotitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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