MCID: PRT026
MIFTS: 40

Parotitis

Categories: Endocrine diseases, Oral diseases
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Aliases & Classifications for Parotitis

MalaCards integrated aliases for Parotitis:

Name: Parotitis 11 53 43 14 16 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:10301
MeSH 43 D010309
NCIt 49 C114281
SNOMED-CT 68 196481002
ICD10 31 K11.2
UMLS 71 C0030583

Summaries for Parotitis

Disease Ontology: 11 A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary: Parotitis is related to meningitis and sjogren syndrome. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor Kazal Type 1), and among its related pathways/superpathways are Innate Immune System and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone marrow and pancreas, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia: 75 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 665)
# Related Disease Score Top Affiliating Genes
1 meningitis 31.0 MMP9 CRP ALB
2 sjogren syndrome 30.6 TRIM21 SSB LTF CD79A
3 orchitis 30.6 CRP CD8A CD4
4 kawasaki disease 30.5 MMP9 MMP2 CRP
5 bell's palsy 30.4 CRP CD8A CD4 ALB
6 reactive arthritis 30.3 LTF CRP CD79A
7 facial paralysis 30.3 CRP CD8A CD4 ALB
8 immunoglobulin alpha deficiency 30.2 CD8A CD79A CD4
9 meningoencephalitis 30.2 CRP CD8A CD79A CD4 ALB
10 chickenpox 30.2 CRP CD8A CD4 ALB
11 cervical adenitis 30.2 CRP CD4
12 sialadenitis 30.1 TRIM21 SSB MMP2 CD4 BPIFA2
13 acquired immunodeficiency syndrome 30.1 CRP CD79A CD4 ALB
14 mediastinitis 30.0 CRP CD4 ALB
15 scarlet fever 30.0 CRP CD4 ALB
16 keratoconjunctivitis 30.0 TRIM21 LTF ALB
17 mesenteric lymphadenitis 30.0 CRP ALB
18 cellulitis 29.9 CRP CD8A CD4 ALB
19 paralytic ileus 29.9 CRP ALB
20 severe cutaneous adverse reaction 29.9 CRP CD8A CD4
21 decubitus ulcer 29.9 MMP9 CRP ALB
22 appendicitis 29.9 MMP9 CRP ALB
23 aseptic meningitis 29.8 CRP CD8A CD4 ALB
24 amebiasis 29.8 CD79A CD4 ALB
25 hepatitis a 29.8 G6PD CD4 ALB
26 actinomycosis 29.8 CRP CD4 ALB
27 autoimmune pancreatitis 29.8 SPINK1 CRP CD4
28 acute myocarditis 29.8 CRP CD8A CD4
29 septic arthritis 29.8 CRP CD4 ALB
30 alcohol use disorder 29.7 CRP CD4 ALB
31 sarcoidosis 1 29.7 CRP CD8A CD4 ALB
32 pfeiffer syndrome 29.7 CRP CD8A CD4
33 bronchitis 29.6 MMP9 LTF CRP ALB
34 dengue disease 29.6 CD8A CD4 ALB
35 exanthem 29.6 TRIM21 CRP CD8A CD4 ALB
36 secondary syphilis 29.6 CRP CD8A CD4
37 oral candidiasis 29.6 LTF CD8A CD4
38 iridocyclitis 29.6 CRP CD8A CD4
39 dysentery 29.5 LTF CRP CD4 ALB
40 anterior uveitis 29.5 CRP CD8A CD4
41 celiac disease 1 29.5 CRP CD8A CD79A CD4 ALB
42 pharyngitis 29.5 CRP CD8A CD4
43 panniculitis 29.5 CRP CD8A CD4
44 mikulicz disease 29.5 TRIM21 SSB SPINK1 CRP CD4
45 syphilis 29.4 CRP CD8A CD79A CD4 ALB
46 miliary tuberculosis 29.4 CRP CD8A CD4 ALB
47 extrapulmonary tuberculosis 29.4 CRP CD8A CD4 ALB
48 pneumocystosis 29.4 CRP CD8A CD4 ALB
49 herpangina 29.4 CRP CD8A CD4 ALB
50 viral meningitis 29.4 CRP CD8A CD4 ALB

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to Parotitis

Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 ALB CD4 CD79A CMAS CRP G6PD
2 immune system MP:0005387 10 ALB CD4 CD79A CD8A CMAS CRP
3 hematopoietic system MP:0005397 9.7 CD4 CD79A CD8A G6PD KLK4 LTF
4 mortality/aging MP:0010768 9.44 ALB CD4 CD79A CD8A CMAS G6PD

Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2, Phase 3
2 Vaccines Phase 2, Phase 3
3
Morphine Approved, Investigational 57-27-2 5288826
4 Analgesics
5 Analgesics, Opioid
6 Narcotics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II/III of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Healthy Children Aged 5-11 Unknown status NCT04591405 Phase 2, Phase 3
2 Safety and Efficacy of Attenuated Mumps Vaccine (Human Diploid Cell) Unknown status NCT03133923 Phase 2
3 Gender and Opioid Consumption Unknown status NCT03006627 postoperative morphine
4 Treatment of Juvenile Recurrent Parotitis: the Yield of Minimally Invasive Intervention, a Prospective Controlled Study Not yet recruiting NCT04074694

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

Genetic Tests for Parotitis

Anatomical Context for Parotitis

Organs/tissues related to Parotitis:

MalaCards : Salivary Gland, Bone Marrow, Pancreas, Lymph Node, Bone, Adrenal Cortex, Small Intestine

Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 2257)
# Title Authors PMID Year
1
New insights into juvenile parotitis. 53 62
16303695 2005
2
Chronic parotitis: not another SPINKosis. 53 62
15753612 2004
3
68Ga-DOTA-FAPI-04 PET/CT Imaging in a Case of Radioactive Iodine-Induced Chronic Parotitis. 62
36342796 2022
4
Cytology as a rapid tool in diagnosing tuberculosis of the parotid gland: A case series with a review of the literature. 62
35924792 2022
5
Nodular Oncocytic Hyperplasia of Bilateral Parotid Glands With Parapharyngeal Space Extension. 62
33215532 2022
6
Pulmonary manifestations of childhood-onset primary Sjogren's syndrome (SS) masquerading as reactive airways disease in a male patient and review of interstitial lung disease associated with SS. 62
36384806 2022
7
Polymicrobial Acute Suppurative Parotitis in a 33-Day-Old Infant: A Case Report and Review of the Literature. 62
35678072 2022
8
COVID-19-Associated Parotitis in a 10-Week-Old Male. 62
36475193 2022
9
Sialendoscopy in Management of Juvenile Recurrent Parotitis-A Single Centre Experience. 62
36360360 2022
10
Late-onset recurrence of neonatal Group B Streptococcus disease presenting with acute parotitis. 62
35536046 2022
11
COVID-19 Associated Parotitis in a 4-Year-Old Boy. 62
36004746 2022
12
Bilateral parotid gland swelling: An unusual presentation of B cell lymphoma. 62
36165545 2022
13
Pediatric rheumatologists' perspectives on diagnosis, treatment, and outcomes of Sjögren disease in children and adolescents. 62
36064423 2022
14
Epstein-Barr virus-associated acute pancreatitis: a clinical report and review of literature. 62
36064422 2022
15
Management and control issues related to two mumps outbreaks in Houston: Future implications. 62
35959718 2022
16
Do Not Ignore Tuberculosis of the Parotid Gland When Meeting Obvious Infiltration of Neutrophils in a Suspicious Swelling by FNAC. 62
32998533 2022
17
Role of Sialendoscopy in Non-neoplastic Parotid Diseases: A Prospective Study of 241 Patients in Indian Population. 62
35712411 2022
18
Neonatal venolymphatic malformation with spontaneous parotid duct rupture: first case report. 62
35769188 2022
19
Parotitis caused by Mycobacteroides abscessus subspecies abscessus. 62
33246745 2022
20
Differences between radioactive iodine-induced sialadenitis and chronic obstructive parotitis. 62
34776313 2022
21
Acute bilateral suppurative parotitis following treatment of acute decompensated heart failure with noninvasive positive-pressure ventilation. 62
35769180 2022
22
Unusual complications of non-invasive mechanical ventilation (NIV) and high-flow nasal cannula (HFNC): A systematic review. 62
35785884 2022
23
Static Suspension of the Paralyzed Face Utilizing the Midfacial Corridor: Anatomic Evaluation and Surgical Technique. 62
34425593 2022
24
Is seminal quality worsening? A 20-year experience in Córdoba, Argentina. 62
35296953 2022
25
Postoperative infection of the skull base surgical site due to suppurative parotitis: A case report. 62
35801038 2022
26
The applicability of ultrasound in the diagnosis of inflammatory and obstructive diseases of the major salivary glands: a scoping review. 62
34762496 2022
27
Profile analysis of adverse events after boron neutron capture therapy for head and neck cancer: a sub-analysis of the JHN002 study. 62
35388879 2022
28
Parotid irrigation: A promising option for juvenile recurrent parotitis. 62
35256205 2022
29
Childhood esophageal achalasia: Case report from Afghanistan with literature review. 62
35658288 2022
30
Purulent Discharge from Stensen Duct in Neonatal Suppurative Parotitis. 62
34952006 2022
31
Acute parotitis as a presentation of COVID-19? 62
32713097 2022
32
Updates in childhood Sjogren's syndrome. 62
34879027 2022
33
Acute suppurative parotitis caused by foreign body in parotid duct: a case report and literature review. 62
35332755 2022
34
A Retrospective Analysis of Multiple Affected Salivary Gland Diseases: Diagnostic and Therapeutic Benefits of Interventional Sialendoscopy. 62
35324340 2022
35
Cost analysis of sialendoscopy for the treatment of salivary gland disorders in children. 62
34973523 2022
36
Mumps Infection With Symptoms of Parotitis, Pancreatitis, and Orchitis Concurrently in an Adolescent Male. 62
35282503 2022
37
Novel Multidisciplinary Salivary Gland Society (MSGS) Questionnaire: An International Consensus. 62
34236085 2022
38
Common Characteristics and Clinical Management Recommendations for Juvenile Recurrent Parotitis: A 10-Year Tertiary Center Experience. 62
35187385 2022
39
Hypocomplementemia in Primary Sjogren's Syndrome: A Retrospective Study of 120 Treatment-Naive Chinese Patients. 62
35035231 2022
40
Acute Suppurative Parotitis Following Acute Ischemic Stroke: A Case Report. 62
35223274 2022
41
Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity. 62
35903308 2022
42
Treatment of juvenile recurrent parotitis with irrigation therapy without anesthesia. 62
34117898 2022
43
Treatment Strategy for Chronic Obstructive Parotitis Related to Diabetes: A Retrospective Analysis of 12 Cases. 62
35847021 2022
44
Unilateral parotitis following mRNA coronavirus disease 2019 vaccination. 62
35522802 2022
45
Neonatal suppurative parotitis: Case reports and literature review. 62
33955624 2022
46
Infantile Parotid Hemangioma With Diagnostic Dilemma: A Case Report. 62
35095285 2022
47
Long-term outcome of a cohort of 272 patients undergoing sialendoscopy. 62
34674373 2022
48
Pediatricians' Knowledge and Practices Related to Mumps Diagnosis and Prevention. 62
34453916 2021
49
IgG4-related chronic sclerosing sialadenitis in a child with recurrent parotitis: a case report. 62
34930210 2021
50
Mumps in Vaccinated Children and Adolescents: 2007-2019. 62
34814181 2021

Variations for Parotitis

Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for Parotitis

GO Terms for Parotitis

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.43 MMP9 MMP2 KLK4
2 pentose-phosphate shunt, oxidative branch GO:0009051 8.92 H6PD G6PD

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.76 MMP9 MMP2 LTF KLK4
2 oxidoreductase activity, acting on CH-OH group of donors GO:0016614 8.96 H6PD G6PD
3 glucose-6-phosphate dehydrogenase activity GO:0004345 8.92 H6PD G6PD

Sources for Parotitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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