MCID: PRT026
MIFTS: 45

Parotitis

Categories: Endocrine diseases, Oral diseases

Aliases & Classifications for Parotitis

MalaCards integrated aliases for Parotitis:

Name: Parotitis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10301
ICD10 33 K11.2
MeSH 44 D010309
NCIt 50 C114281
SNOMED-CT 68 14756005
UMLS 73 C0030583

Summaries for Parotitis

Disease Ontology : 12 A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary : Parotitis is related to meningoencephalitis and appendicitis. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are AGE/RAGE pathway and LPA receptor mediated events. The drugs Isoniazid and Pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and brain, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 meningoencephalitis 30.3 CD79A ALB
2 appendicitis 29.7 MMP9 ALB
3 parotitis, juvenile recurrent 12.1
4 mumps 10.5
5 orchitis 10.2
6 influenza 10.2
7 extracranial arteriovenous malformation 10.2 MMP9 MMP2
8 focal myositis 10.2 MMP9 MMP2
9 villous adenocarcinoma 10.2 MMP9 MMP2
10 lentigo maligna melanoma 10.2 MMP9 MMP2
11 spastic entropion 10.2 MMP9 MMP2
12 psammomatous meningioma 10.2 MMP9 MMP2
13 acute transverse myelitis 10.2 MMP9 MMP2
14 transverse myelitis 10.2 MMP9 MMP2
15 senile ectropion 10.2 MMP9 MMP2
16 internal hemorrhoid 10.2 MMP9 MMP2
17 light chain deposition disease 10.2 MMP9 MMP2
18 ischemic colitis 10.2 MMP9 MMP2
19 conjunctival nevus 10.2 MMP9 MMP2
20 corneal ulcer 10.2 MMP9 MMP2
21 odontogenic myxoma 10.2 MMP9 MMP2
22 nasal cavity squamous cell carcinoma 10.2 MMP9 MMP2
23 pancreatitis 10.2
24 laryngeal disease 10.1 MMP9 MMP2
25 hypertensive heart disease 10.1 MMP9 MMP2
26 pneumothorax 10.1 MMP9 MMP2
27 aortic aneurysm, familial thoracic 1 10.1 MMP9 MMP2
28 adenomyosis 10.1 MMP9 MMP2
29 skin melanoma 10.1 MMP9 MMP2
30 pancreas disease 10.1 SPINK1 ALB
31 chronic graft versus host disease 10.1 CD79A ALB
32 sjogren syndrome 10.1
33 pneumonia 10.1
34 grade iii astrocytoma 10.1 MMP9 MMP2
35 focal dermal hypoplasia 10.1 CD79A ALB
36 aortic disease 10.1 MMP9 MMP2
37 severe pre-eclampsia 10.1 MMP9 ALB
38 ulcerative stomatitis 10.1 CD79A ALB
39 bacterial meningitis 10.1 MMP9 ALB
40 protein-losing enteropathy 10.1 CD79A ALB
41 hypersensitivity reaction type iii disease 10.1 CD79A ALB
42 dysentery 10.1 LTF ALB
43 lipoid nephrosis 10.1 CD79A ALB
44 varicose veins 10.1 MMP9 MMP2
45 membranoproliferative glomerulonephritis 10.1 CD79A ALB
46 tongue cancer 10.1 MMP9 MMP2
47 leukemia 10.0
48 facial paralysis 10.0
49 lymphadenitis 10.0
50 meningitis 10.0

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to Parotitis

Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 CD79A G6PD LTF MMP2 MMP9 SPINK1
2 homeostasis/metabolism MP:0005376 9.56 ALB CD79A G6PD H6PD LTF MMP2
3 neoplasm MP:0002006 9.02 ALB CD79A LTF MMP2 MMP9

Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
2
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
3
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
4 Cytochrome P-450 CYP3A Inducers Phase 4
5 Lipid Regulating Agents Phase 4
6 Antimetabolites Phase 4,Phase 1,Phase 2
7 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 1,Phase 2
8 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
9 Hypolipidemic Agents Phase 4
10 Antitubercular Agents Phase 4,Phase 1,Phase 2
11 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
12 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
13 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2
14 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15
Tetracycline Approved, Vet_approved Phase 3 60-54-8 5353990
16 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
17
Fludarabine Approved Phase 1, Phase 2,Phase 2 75607-67-9, 21679-14-1 30751
18
leucovorin Approved Phase 1, Phase 2 58-05-9 6006 143
19
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
20
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
21
Vidarabine Approved, Investigational Phase 1, Phase 2 24356-66-9 32326 21704
22
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
23
Methotrexate Approved Phase 1, Phase 2 59-05-2, 1959-05-2 126941
24
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
25
Phenytoin Approved, Vet_approved Phase 1, Phase 2 57-41-0 1775
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
27 Calcium, Dietary Phase 1, Phase 2
28 Antibodies Phase 1, Phase 2
29 Antimetabolites, Antineoplastic Phase 1, Phase 2
30 Antineoplastic Agents, Alkylating Phase 1, Phase 2
31 Calcineurin Inhibitors Phase 1, Phase 2
32 Adjuvants, Immunologic Phase 1, Phase 2
33 Antiviral Agents Phase 1, Phase 2
34 Cyclosporins Phase 1, Phase 2
35 Interleukin-4 Phase 1, Phase 2
36 Mitogens Phase 1, Phase 2
37 Alkylating Agents Phase 1, Phase 2
38 Vitamin B9 Phase 1, Phase 2
39 Vitamin B Complex Phase 1, Phase 2
40 Diuretics, Potassium Sparing Phase 1, Phase 2
41 Immunosuppressive Agents Phase 1, Phase 2
42 Folic Acid Antagonists Phase 1, Phase 2
43 Anticonvulsants Phase 1, Phase 2
44 Antifungal Agents Phase 1, Phase 2
45 Sodium Channel Blockers Phase 1, Phase 2
46 Hormones Phase 1, Phase 2
47 Krestin Phase 1, Phase 2
48 Interleukin-2 Phase 1, Phase 2
49 Folate Phase 1, Phase 2
50 Antirheumatic Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Three Regimens to Prevent Tuberculosis in HIV-Infected Patients With Anergy Completed NCT00402610 Phase 4 isoniazid, rifampin + isoniazid, rifampin + pyrazinamide or not treatment
2 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Completed NCT02880865 Phase 4
3 Comparative Study of the Immunogenicity of MMR (Measles, Mumps and Rubella) Single Dose and Multidose Presentations Completed NCT01777529 Phase 4
4 Immunogenicity and Safety of Hepatitis A Vaccine Given at the Same Time of Measles, Mumps, Rubella Combined Vaccine Completed NCT00313950 Phase 4
5 Immunogenicity and Safety of Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00126997 Phase 4
6 Safety & Immunogenicity Study of Meningococcal Vaccine GSK134612 Given With Priorix-Tetra™ to 12-23 Month-Old Children Completed NCT00474266 Phase 3
7 Safety and Immunogenicity Study of Live Attenuated Mumps Vaccines in Healthy Infants Completed NCT02692599 Phase 3
8 Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age Completed NCT02184572 Phase 3
9 Immunogenicity and Safety of GSK Biologicals' Combined Measles-mumps-rubella Vaccine in Volunteers, Seven Years of Age and Older Completed NCT02058563 Phase 3
10 Study of Immunogenicity, Reactogenicity and Safety of the Combined Measles, Mumps and Rubella Vaccine Produced by Bio-Manguinhos/Fiocruz in Children 12-15 Months of Age, Followed by Tetraviral Vaccine in Children 15-18 Months. Completed NCT01991899 Phase 3
11 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life Completed NCT01681992 Phase 3
12 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Subjects Four to Six Years of Age Completed NCT01621802 Phase 3
13 Safety, Tolerability, and Immunogenicity of Measles, Mumps, Rubella, and Varicella (MMRV) Vaccine Made With an Alternative Manufacturing Process (AMP)(V221-027) Completed NCT01536405 Phase 3
14 Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers Completed NCT01188343 Phase 3
15 Comparison of GSK Measles-mumps-rubella-varicella (MMRV) Vaccine Versus PriorixTM Completed NCT00969436 Phase 3
16 Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136 Completed NCT00751348 Phase 3
17 Long-term Follow-up on Immunogenicity & Safety of Measles-Mumps-Rubella-Varicella (MMRV) Combined Vaccine Completed NCT00406211 Phase 3
18 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127023 Phase 3
19 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127010 Phase 3
20 Study to Evaluate Frozen Versus Refrigerated MMRV (Combined Measles, Mumps, Rubella, and Varicella) Investigational Vaccine (V221-016) Completed NCT00092430 Phase 3
21 A Study of An Approved Vaccine at Mumps Expiry Potency in Healthy Children 12 to 18 Months of Age (V205C-007)(COMPLETED) Completed NCT00092391 Phase 3
22 Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00245037 Phase 1, Phase 2 busulfan;cyclosporine;fludarabine phosphate;mycophenolate mofetil;Granulocyte colony-stimulating factor (G-CSF);Phenytoin;Methotrexate
23 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00353288 Phase 2
24 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00352898 Phase 2
25 Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Active, not recruiting NCT03133923 Phase 2
26 A Phase I, Safety Study of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Children Completed NCT01712906 Phase 1
27 Gender and Opioid Consumption Unknown status NCT03006627 Not Applicable postoperative morphine
28 Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome Completed NCT03157011 Not Applicable
29 Serological Study in Children 12 to 23 Months Vaccinated With MMR (Measles, Mumps and Rubella) Completed NCT01874457
30 Making Decisions About the Measles-Mumps-Rubella Vaccine Completed NCT01369394 Not Applicable
31 Measles, Mumps, and Rubella (MMR) Immunity in College Students Completed NCT00962819
32 Safety Study of Measles-Mumps-Rubella-Varicella (MMRV) Vaccine, Priorix-Tetra™ in Children Living in the Philippines Withdrawn NCT01738841

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

Genetic Tests for Parotitis

Anatomical Context for Parotitis

MalaCards organs/tissues related to Parotitis:

41
Salivary Gland, Thyroid, Brain, Myeloid, Skin, Heart, Pancreas

Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 654)
# Title Authors Year
1
Neonatal Parotitis. ( 29428272 )
2018
2
Could human bocavirus be a causative agent of parotitis in children? ( 29751940 )
2018
3
Mucormycotic parotitis and otitis causing facial nerve palsy in a diabetic patient. ( 29904969 )
2018
4
Non-mumps Viral Parotitis During the 2014-2015 Influenza Season in the United States. ( 29617951 )
2018
5
<i>Mycobacterium mageritense</i> Parotitis in an Immunocompetent Adult. ( 29434394 )
2018
6
Sialendoscopy in treatment of adult chronic recurrent parotitis without sialolithiasis. ( 29290052 )
2018
7
Is Parotitis One More Complication of Influenza? The Ongoing Challenge of Determining Causal Associations. ( 29617960 )
2018
8
Methicillin-Resistant Staphylococcus aureus Parotitis Leading to Mortality in an Adolescent Male. ( 29939841 )
2018
9
Acute parotitis due to MRSA causing Lemierre's syndrome. ( 29942528 )
2018
10
Influenza-Associated Parotitis During the 2014-2015 Influenza Season in the United States. ( 29617957 )
2018
11
Acute Parotitis after Lower Limb Amputation: A Case Report of a Rare Complication. ( 29736287 )
2018
12
Pediatric Primary Tuberculous Osteomyelitis of the Mandible Mimicking Parotitis. ( 29552433 )
2018
13
Sialoendoscopy for treatment of juvenile recurrent parotitis: The Brescia experience. ( 29447807 )
2018
14
Bruxism-induced parotitis: A retrospective case series analysis. ( 30048228 )
2018
15
Juvenile recurrent parotitis: A systematic review of treatment studies. ( 30055724 )
2018
16
Role of sialendoscopy in juvenile recurrent parotitis (JRP). ( 28669808 )
2017
17
Viral etiology of sporadic cases of parotitis among children in Korea during 2013-2014. ( 28876460 )
2017
18
Challenging Case of Parotitis: A Comprehensive Approach. ( 29181524 )
2017
19
Chronic Recurrent Non-specific Parotitis: A Case Report and Review. ( 28458496 )
2017
20
Sialoendoscopy combined with an internal stent and postoperative massage as a comprehensive treatment of delayed I(131)-induced parotitis. ( 28697989 )
2017
21
Sialendoscopic Approach in Management of Juvenile Recurrent Parotitis. ( 29238673 )
2017
22
Magnetic Resonance Imaging Findings of Mumps Meningoencephalitis with Bilateral Hippocampal Lesions without Preceding Acute Parotitis: A Case Report. ( 28246518 )
2017
23
Parotitis as an Initial Symptom of Kawasaki Disease. ( 28593063 )
2017
24
Development of acute parotitis after non-invasive ventilation. ( 28840025 )
2017
25
An unusual case of acute parotitis in a young adult. ( 28742741 )
2017
26
A case of neuromyelitis optica spectrum disorder (NMOSD) with SjAPgren's syndrome manifested only brain involvement by preceding parotitis. ( 28132975 )
2017
27
Facial and limb angioedema with parotitis and Kikuchi-like necrotizing lymphadenitis preceding neuropsychiatric systemic lupus erythematosus in a young African American male. ( 28849689 )
2017
28
Core curriculum illustration: pediatric viral parotitis. ( 28593330 )
2017
29
Chymotrypsin with sialendoscopy-assisted surgery for the treatment of chronic obstructive parotitis. ( 28279602 )
2017
30
Erratum to: Pediatric suppurative parotitis caused by Burkholderia pseudomallei. ( 28138332 )
2017
31
Ultrasound elastography in diagnosis and follow-up for patients with chronic recurrent parotitis. ( 28885206 )
2017
32
Role of the Accessory Parotid Gland in the Etiology of Parotitis: Statistical Analysis of Sialographic Features. ( 26913509 )
2016
33
Concomitant Suppurative Parotitis and Condylar Osteomyelitis. ( 27717819 )
2016
34
Eosinophilic sialodochitis: redefinition of 'allergic parotitis' and 'sialodochitis fibrinosa'. ( 27748012 )
2016
35
Acute Parotitis as a Complication of Noninvasive Ventilation. ( 26928643 )
2016
36
Streptococcus pneumoniae bacteraemia due to parotitis in a patient with systemic sclerosis and secondary SjAPgren's syndrome. ( 28348790 )
2016
37
Sialendoscopy-assisted treatment for chronic obstructive parotitis related to Sjogren syndrome. ( 28049607 )
2016
38
Bilateral parotitis in a patient under continuous positive airway pressure treatment. ( 27793244 )
2016
39
Pediatric suppurative parotitis caused by Burkholderia pseudomallei. ( 27843446 )
2016
40
Diagnosing Juvenile Recurrent Parotitis. Case Reports. ( 26939156 )
2016
41
Tuberculous Lymphadenitis and Parotitis. ( 28084205 )
2016
42
Parotitis and Sialendoscopy of the Parotid Gland. ( 26912292 )
2016
43
Sialendoscopic treatment of recurrent juvenile parotitis: A South African case series. ( 27499410 )
2016
44
Function of the parotid gland in juvenile recurrent parotitis: a case series. ( 26852271 )
2016
45
Presentation of acute suppurative parotitis in a newborn with incessant crying. ( 27986789 )
2016
46
Neonatal Suppurative Parotitis: Two Cases. ( 27351362 )
2016
47
Decreased salivary matrix metalloproteinase-8 reflecting a defensive potential in juvenile parotitis. ( 26746616 )
2016
48
A case of a male presenting with fever, parotitis, epididymo-orchitis, and kidney injury. ( 27012169 )
2016
49
Chronic parotitis with multiple calcifications: Clinical and sialendoscopic findings. ( 27861944 )
2016
50
Botulinum Toxin for the Management of SjAPgren Syndrome-Associated Recurrent Parotitis. ( 27400144 )
2016

Variations for Parotitis

Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for Parotitis

GO Terms for Parotitis

Cellular components related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.55 ALB G6PD LTF MMP9 SPINK1
2 extracellular space GO:0005615 9.02 ALB LTF MMP2 MMP9 SPINK1
3 tertiary granule lumen GO:1904724 8.96 LTF MMP9

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose metabolic process GO:0006006 9.48 G6PD H6PD
2 extracellular matrix disassembly GO:0022617 9.46 MMP2 MMP9
3 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.43 MMP2 MMP9
4 embryo implantation GO:0007566 9.4 MMP2 MMP9
5 retina homeostasis GO:0001895 9.37 ALB LTF
6 cellular protein metabolic process GO:0044267 9.33 ALB LTF MMP2
7 collagen catabolic process GO:0030574 9.32 MMP2 MMP9
8 endodermal cell differentiation GO:0035987 9.26 MMP2 MMP9
9 pentose-phosphate shunt GO:0006098 8.96 G6PD H6PD
10 NADP metabolic process GO:0006739 8.62 G6PD H6PD

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.16 G6PD H6PD
2 serine-type endopeptidase activity GO:0004252 9.13 LTF MMP2 MMP9
3 glucose-6-phosphate dehydrogenase activity GO:0004345 8.62 G6PD H6PD

Sources for Parotitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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