MCID: PRT026
MIFTS: 42

Parotitis

Categories: Endocrine diseases, Oral diseases

Aliases & Classifications for Parotitis

MalaCards integrated aliases for Parotitis:

Name: Parotitis 12 54 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10301
MeSH 44 D010309
NCIt 50 C114281
SNOMED-CT 67 196481002
ICD10 32 K11.2
UMLS 70 C0030583

Summaries for Parotitis

Disease Ontology : 12 A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary : Parotitis is related to meningitis and orchitis. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor Kazal Type 1), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Primary immunodeficiency. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, skin and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 73 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 559)
# Related Disease Score Top Affiliating Genes
1 meningitis 30.9 MMP9 CRP ALB
2 orchitis 30.4 CRP CD8A CD4
3 vasculitis 30.1 LTF CRP CD79A
4 scarlet fever 30.0 CRP ALB
5 facial paralysis 30.0 CRP CD8A CD4 ALB
6 immunoglobulin alpha deficiency 30.0 CD8A CD79A CD4
7 kawasaki disease 30.0 MMP9 CRP CD4 ALB
8 chickenpox 29.9 CRP CD8A CD4 ALB
9 paralytic ileus 29.9 CRP ALB
10 cervical adenitis 29.9 CRP CD4
11 sialadenitis 29.9 TRIM21 SSB MMP2 CD4
12 meningoencephalitis 29.9 CRP CD8A CD79A CD4 ALB
13 pyuria 29.8 CRP ALB
14 variola major 29.8 CD8A CD4
15 appendicitis 29.8 MMP9 CRP ALB
16 periodontitis 29.8 MMP9 MMP2 CRP
17 otitis media 29.7 CRP CD79A ALB
18 keratoconjunctivitis 29.7 TRIM21 MMP9 ALB
19 sjogren syndrome 29.7 TRIM21 SSB LTF CD79A
20 cellulitis 29.7 CRP CD8A CD4 ALB
21 salmonellosis 29.6 CD8A CD4 ALB
22 amebiasis 29.6 CD79A CD4 ALB
23 mediastinitis 29.6 CRP CD4 ALB
24 actinomycosis 29.5 CRP CD4 ALB
25 dysentery 29.5 CRP CD4 ALB
26 acquired immunodeficiency syndrome 29.5 CRP CD79A CD4 ALB
27 bronchitis 29.5 MMP9 LTF CRP ALB
28 bell's palsy 29.5 CD8A CD4 ALB
29 sarcoidosis 1 29.5 CRP CD8A CD4
30 anemia, autoimmune hemolytic 29.4 G6PD CD8A CD4
31 disease by infectious agent 29.3 CRP CD8A CD4 ALB
32 pharyngitis 29.3 CRP CD8A CD4
33 panniculitis 29.3 CRP CD8A CD4
34 severe cutaneous adverse reaction 29.3 CRP CD8A CD4
35 syphilis 29.1 CRP CD8A CD79A CD4 ALB
36 pulmonary disease, chronic obstructive 29.1 MMP9 CRP CD8A CD4 ALB
37 secondary syphilis 29.1 CRP CD8A CD79A CD4
38 respiratory failure 29.1 G6PD CRP CD8A CD4 ALB
39 exanthem 29.0 TRIM21 CRP CD8A CD4 ALB
40 salivary gland disease 28.9 TRIM21 SSB LTF CD8A CD4
41 deficiency anemia 28.6 LTF G6PD CRP CD8A CD4 ALB
42 keratoconjunctivitis sicca 28.5 TRIM21 SSB LTF CD79A CD4 ALB
43 hypertension, essential 28.3 MMP9 MMP2 KLK4 CRP CD8A CD4
44 parotid disease 28.0 TRIM21 SSB SPINK1 KLK4 CRP CD8A
45 systemic lupus erythematosus 27.9 TRIM21 SSB MMP9 MMP2 LTF CRP
46 mumps 11.1
47 parotitis, juvenile recurrent 11.0
48 lemierre's syndrome 11.0
49 measles 10.4
50 extracranial arteriovenous malformation 10.4 MMP9 MMP2

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to Parotitis

Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 CD4 CD79A CD8A G6PD LTF MMP2
2 homeostasis/metabolism MP:0005376 9.93 ALB CD4 CD79A CRP G6PD H6PD
3 immune system MP:0005387 9.7 ALB CD4 CD79A CD8A CRP LTF
4 mortality/aging MP:0010768 9.36 ALB CD4 CD79A CD8A G6PD KLK4

Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2, Phase 3
2 Vaccines Phase 2, Phase 3
3
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
4
Sargramostim Approved, Investigational Phase 1, Phase 2 123774-72-1, 83869-56-1
5
Methotrexate Approved Phase 1, Phase 2 1959-05-2, 59-05-2 126941
6
Levoleucovorin Approved, Investigational Phase 1, Phase 2 68538-85-2 149436
7
Phenytoin Approved, Vet_approved Phase 1, Phase 2 57-41-0 1775
8
Vidarabine Approved, Investigational Phase 1, Phase 2 24356-66-9 32326 21704
9
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
10
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
11
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
12
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
13
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
14
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
15
Molgramostim Investigational Phase 1, Phase 2 99283-10-0
16 Anti-Infective Agents Phase 1, Phase 2
17 Sodium Channel Blockers Phase 1, Phase 2
18 Alkylating Agents Phase 1, Phase 2
19 Vitamin B9 Phase 1, Phase 2
20 Antirheumatic Agents Phase 1, Phase 2
21 Folic Acid Antagonists Phase 1, Phase 2
22 Mitogens Phase 1, Phase 2
23 polysaccharide-K Phase 1, Phase 2
24 Immunosuppressive Agents Phase 1, Phase 2
25 Adjuvants, Immunologic Phase 1, Phase 2
26 Anti-Bacterial Agents Phase 1, Phase 2
27 Diuretics, Potassium Sparing Phase 1, Phase 2
28 Antibiotics, Antitubercular Phase 1, Phase 2
29 Hormones Phase 1, Phase 2
30 Vitamin B Complex Phase 1, Phase 2
31 Cyclosporins Phase 1, Phase 2
32 Folate Phase 1, Phase 2
33 Calcineurin Inhibitors Phase 1, Phase 2
34 Antifungal Agents Phase 1, Phase 2
35 Antimetabolites Phase 1, Phase 2
36 Anticonvulsants Phase 1, Phase 2
37 Antibodies Phase 1, Phase 2
38 Immunoglobulins Phase 1, Phase 2
39 Antitubercular Agents Phase 1, Phase 2
40 Interleukin-2 Phase 1, Phase 2
41 Calcium, Dietary Phase 1, Phase 2
42 Dermatologic Agents Phase 1, Phase 2
43 Interleukin-4 Phase 1, Phase 2
44
Calcium Nutraceutical Phase 1, Phase 2 7440-70-2 271
45
Morphine Approved, Investigational 57-27-2 5288826
46 Narcotics
47 Analgesics
48 Analgesics, Opioid

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II/III of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Healthy Children Aged 5-11 Recruiting NCT04591405 Phase 2, Phase 3
2 Safety and Efficacy of Attenuated Mumps Vaccine (Human Diploid Cell) Unknown status NCT03133923 Phase 2
3 A Phase I/II Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplant for the Treatment of Patients With Hematologic Malignancies Using Busulfan, Fludarabine and Total Body Irradiation Completed NCT00245037 Phase 1, Phase 2 busulfan;cyclosporine;fludarabine phosphate;mycophenolate mofetil;Granulocyte colony-stimulating factor (G-CSF);Phenytoin;Methotrexate
4 Gender and Opioid Consumption Unknown status NCT03006627 postoperative morphine
5 Treatment of Juvenile Recurrent Parotitis: the Yield of Minimally Invasive Intervention, a Prospective Controlled Study Not yet recruiting NCT04074694

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

Genetic Tests for Parotitis

Anatomical Context for Parotitis

MalaCards organs/tissues related to Parotitis:

40
Salivary Gland, Skin, Lung, Heart, Thyroid, Bone, Myeloid

Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 2188)
# Title Authors PMID Year
1
New insights into juvenile parotitis. 61 54
16303695 2005
2
Chronic parotitis: not another SPINKosis. 61 54
15753612 2004
3
Juvenile primary Sjögren's syndrome with ranula: is ranula a clinical sign that leads to early detection of Sjögren's syndrome? 61
32803681 2021
4
Clinical characteristics that predict parotid abscess: An observational cohort study. 61
33777393 2021
5
Conservative Management of Chronic Suppurative Parotitis in Patients with Sjögren Syndrome: A Case Series. 61
33739960 2021
6
Juvenile recurrent parotitis: Review and proposed management algorithm. 61
33421670 2021
7
Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis. 61
33807303 2021
8
Isatis indigotica: a review of phytochemistry, pharmacological activities and clinical applications. 61
33779758 2021
9
Factors predicting length of stay in patients hospitalized for acute parotitis. 61
33087427 2021
10
Facial nerve palsy secondary to parotitis. 61
33541969 2021
11
Clinical and Sialographic Imaging Features of 131I Radiation-induced Submandibular Gland Sialadenitis. 61
32896506 2021
12
Vestibular Neuritis as Clinical Presentation of COVID-19. 61
33570425 2021
13
Positive Effects of Local Botulinum Toxin Injection and Colchicine for Complicated Chronic Recurrent Parotitis: A Case Report. 61
32910892 2021
14
Internal Jugular Vein and Cerebral Venous Sinus Infective Thrombophlebitis Detected With 99mTc-HMPAO White Blood Cell Scintigraphy. 61
33156045 2021
15
Not all Sicca is Sjögren's and not all Sjögren's is Sicca. 61
33659130 2021
16
Surgical Management of Sialorrhea: A Systematic Review and Meta-analysis. 61
33494642 2021
17
Deep Sedation for Pediatric Parotid Sialendoscopy in Juvenile Recurrent Parotitis. 61
33451162 2021
18
COVID-19 associated parotitis. 61
32631770 2021
19
Clinical Manifestations Associated with Bartonella henselae Infection in a Tropical Region. 61
33021197 2021
20
Rare case of tubercular parotid abscess. 61
33431537 2021
21
Parotitis due to Burkholderia cepacia infection after autologous hematopoietic stem cell transplantation. 61
32564412 2020
22
Identification and description of mumps cases in a non-outbreak setting and evaluation of the effectiveness of mumps-containing vaccines over time. 61
32401599 2020
23
[Juvenile recurrent parotitis complicated with selective IgA deficiency: a case report]. 61
33280369 2020
24
A Presentation of Pediatric Sjögren's Syndrome with Abducens Nerve Palsy. 61
33316834 2020
25
Childhood Sjögren syndrome: features of an international cohort and application of the 2016 ACR/EULAR classification criteria. 61
33280020 2020
26
[The relationship between Sjogren's syndrome, systemic sclerosis and lymphoproliferative diseases]. 61
33720584 2020
27
Bilateral total conservative parotidectomy: a tale behind an aesthetic surgery. 61
33298480 2020
28
Childhood Sjogren's syndrome: An Italian case series and a literature review-based cohort. 61
33261821 2020
29
Parotitis caused by Mycobacteroides abscessus subspecies abscessus. 61
33246745 2020
30
Sialadenitis: A Possible Early Manifestation of COVID-19. 61
32833242 2020
31
Long-Term Results of a Pedicled and Innervated Sternocleidomastoid Muscle Flap to Immediately Reconstruct Superficial Parotidectomy Defects. 61
32456521 2020
32
Nodular Oncocytic Hyperplasia of Bilateral Parotid Glands With Parapharyngeal Space Extension. 61
33215532 2020
33
Botulinum Toxin Injection for Chronic Parotitis: A Multi-Center and Prospective Trial. 61
33111982 2020
34
Unilateral Sialendoscopy for Juvenile Recurrent Parotitis: What Happens to the Other Side? 61
33098313 2020
35
Neonatal Acute Suppurative Parotitis. 61
32476464 2020
36
[Cervicofacial cellulitis complicated by internal jugular vein thrombosis]. 61
32505376 2020
37
Do Not Ignore Tuberculosis of the Parotid Gland When Meeting Obvious Infiltration of Neutrophils in a Suspicious Swelling by FNAC. 61
32998533 2020
38
Distal Renal Tubular Acidosis in Sjögren's Syndrome: A Case Report. 61
33083163 2020
39
[Immune disorders associated with juvenile recurrent chronic parotitis]. 61
33008791 2020
40
Parotitis-Like Symptoms Associated with COVID-19, France, March-April 2020. 61
32491984 2020
41
Heerfordt-Waldenström Syndrome Manifesting as Cardiac Sarcoidosis. 61
32983747 2020
42
[Investigation of active components and mechanism of Pudilan Xiaoyan Oral Liquid based on network pharmacology]. 61
33164355 2020
43
[Product improvement and secondary development of Pudilan Xiaoyan Oral Liquid based on clinical medication]. 61
33164354 2020
44
Unusually sited lower third molar. 61
32943442 2020
45
SLC12A2 mutations cause NKCC1 deficiency with encephalopathy and impaired secretory epithelia. 61
32754646 2020
46
Australian mumps serosurvey 2012-2013: any cause for concern? 61
32829703 2020
47
Parotitis Following Routine Use of Sodium Deoxycholate for Jowl Contouring. 61
32826604 2020
48
Acute Parotitis: A Possible Precocious Clinical Manifestation of SARS-CoV-2 Infection? 61
32369434 2020
49
Acute parotitis as a presentation of COVID-19? 61
32713097 2020
50
L-asparaginase-induced Parotitis in an Elderly Patient with Acute Lymphoblastic Leukemia. 61
32296003 2020

Variations for Parotitis

Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for Parotitis

Pathways related to Parotitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 CD8A CD79A CD4
2 10.38 CD8A CD79A CD4

GO Terms for Parotitis

Cellular components related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 SPINK1 MMP9 MMP2 LTF KLK4 CRP

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to amyloid-beta GO:1904645 9.43 MMP9 MMP2
2 pentose-phosphate shunt GO:0006098 9.4 H6PD G6PD
3 positive regulation of viral entry into host cell GO:0046598 9.37 TRIM21 CD4
4 extracellular matrix disassembly GO:0022617 9.33 MMP9 MMP2 KLK4
5 cellular response to UV-A GO:0071492 9.32 MMP9 MMP2
6 NADP metabolic process GO:0006739 9.26 H6PD G6PD
7 negative regulation by host of viral process GO:0044793 8.96 LTF CRP
8 pentose-phosphate shunt, oxidative branch GO:0009051 8.62 H6PD G6PD

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 TRIM21 MMP9 G6PD CRP CD79A CD4
2 serine-type endopeptidase activity GO:0004252 9.26 MMP9 MMP2 LTF KLK4
3 oxidoreductase activity, acting on CH-OH group of donors GO:0016614 9.16 H6PD G6PD
4 glucose-6-phosphate dehydrogenase activity GO:0004345 8.62 H6PD G6PD

Sources for Parotitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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