Parotitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRT026 MIFTS: 46	Parotitis Categories: Endocrine diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Parotitis

MalaCards integrated aliases for Parotitis:

Name: Parotitis ¹² ⁵⁶ ⁴⁵ ¹⁵ ¹⁷ ⁷⁴

Classifications:

MalaCards categories:
Anatomical: Oral diseases Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the digestive system

Diseases of oral cavity, salivary glands and jaws

Diseases of salivary glands

Sialoadenitis

External Ids:

Disease Ontology ¹² DOID:10301

MeSH ⁴⁵ D010309

NCIt ⁵¹ C114281

SNOMED-CT ⁶⁹ 14756005

ICD10 ³⁴ K11.2

EFO ¹⁷ EFO_0007423

UMLS ⁷⁴ C0030583

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Summaries for Parotitis

Disease Ontology : ¹² A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary : Parotitis is related to meningoencephalitis and appendicitis. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are AGE/RAGE pathway and LPA receptor mediated events. The drugs Isoniazid and Pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : ⁷⁷ Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

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Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)

#	Related Disease	Score	Top Affiliating Genes
1	meningoencephalitis	30.1	ALB CD79A
2	appendicitis	29.8	ALB MMP9
3	parotitis, juvenile recurrent	12.1
4	lemierre's syndrome	11.5
5	mumps	10.5
6	extracranial arteriovenous malformation	10.3	MMP2 MMP9
7	focal myositis	10.3	MMP2 MMP9
8	villous adenocarcinoma	10.3	MMP2 MMP9
9	sjogren syndrome	10.3
10	facial paralysis	10.3
11	spastic entropion	10.3	MMP2 MMP9
12	lentigo maligna melanoma	10.3	MMP2 MMP9
13	psammomatous meningioma	10.3	MMP2 MMP9
14	acute transverse myelitis	10.3	MMP2 MMP9
15	transverse myelitis	10.3	MMP2 MMP9
16	senile ectropion	10.3	MMP2 MMP9
17	internal hemorrhoid	10.3	MMP2 MMP9
18	ischemic colitis	10.3	MMP2 MMP9
19	light chain deposition disease	10.2	MMP2 MMP9
20	conjunctival nevus	10.2	MMP2 MMP9
21	orchitis	10.2
22	corneal ulcer	10.2	MMP2 MMP9
23	nasal cavity squamous cell carcinoma	10.2	MMP2 MMP9
24	odontogenic myxoma	10.2	MMP2 MMP9
25	newcastle disease	10.2	MMP2 MMP9
26	laryngeal disease	10.2	MMP2 MMP9
27	influenza	10.2
28	hypertensive heart disease	10.2	MMP2 MMP9
29	pneumothorax	10.2	MMP2 MMP9
30	aortic aneurysm, familial abdominal, 1	10.2	MMP2 MMP9
31	adenomyosis	10.2	MMP2 MMP9
32	pancreatitis	10.2
33	pancreas disease	10.2	ALB SPINK1
34	grade iii astrocytoma	10.1	MMP2 MMP9
35	skin melanoma	10.1	MMP2 MMP9
36	pneumonia	10.1
37	aortic disease	10.1	MMP2 MMP9
38	severe pre-eclampsia	10.1	ALB MMP9
39	bacterial meningitis	10.1	ALB MMP9
40	dysentery	10.1	ALB LTF
41	varicose veins	10.1	MMP2 MMP9
42	leukemia	10.1
43	sialadenitis	10.1
44	lymphadenitis	10.1
45	meningitis	10.1
46	inguinal hernia	10.1	MMP2 MMP9
47	kernicterus	10.1	ALB G6PD
48	gingivitis	10.1	LTF MMP9
49	mastitis	10.1	ALB LTF
50	senile cataract	10.1	ALB G6PD

Graphical network of the top 20 diseases related to Parotitis:

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Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.63	CD79A G6PD LTF MMP2 MMP9 SPINK1
2	homeostasis/metabolism	MP:0005376	9.56	ALB CD79A G6PD H6PD LTF MMP2
3	neoplasm	MP:0002006	9.02	ALB CD79A LTF MMP2 MMP9

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Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Isoniazid

Approved, Investigational

Phase 4

54-85-3

3767

Pyrazinamide

Approved, Investigational

Phase 4

98-96-4

1046

Rifampicin

Approved

Phase 4

13292-46-1

5381226 5458213

Immunologic Factors

Phase 4,Phase 3,Phase 2,Phase 1

Vaccines

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 1,Phase 2

Anti-Infective Agents

Phase 4,Phase 3,Phase 1,Phase 2

Antibiotics, Antitubercular

Phase 4,Phase 1,Phase 2

Lipid Regulating Agents

Phase 4

Hypolipidemic Agents

Phase 4

Antimetabolites

Phase 4,Phase 1,Phase 2

Cytochrome P-450 CYP3A Inducers

Phase 4

Antitubercular Agents

Phase 4,Phase 1,Phase 2

Nucleic Acid Synthesis Inhibitors

Phase 4,Phase 1,Phase 2

Tetracycline

Approved, Vet_approved

Phase 3

60-54-8

5353990

Heptavalent Pneumococcal Conjugate Vaccine

Phase 3

Phenytoin

Approved, Vet_approved

Phase 1, Phase 2

57-41-0

1775

leucovorin

Approved

Phase 1, Phase 2

58-05-9

143 6006

Mycophenolic acid

Approved

Phase 1, Phase 2

24280-93-1

446541

Methotrexate

Approved

Phase 1, Phase 2

1959-05-2, 59-05-2

126941

Fludarabine

Approved

Phase 1, Phase 2,Phase 2

75607-67-9, 21679-14-1

30751

Busulfan

Approved, Investigational

Phase 1, Phase 2

55-98-1

2478

Lenograstim

Approved, Investigational

Phase 1, Phase 2

135968-09-1

Sargramostim

Approved, Investigational

Phase 1, Phase 2

123774-72-1, 83869-56-1

Vidarabine

Approved, Investigational

Phase 1, Phase 2

24356-66-9

21704 32326

Miconazole

Approved, Investigational, Vet_approved

Phase 1, Phase 2

22916-47-8

4189

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 1, Phase 2

59-30-3

6037

Calcium

Approved, Nutraceutical

Phase 1, Phase 2

7440-70-2

271

Antibodies

Phase 1, Phase 2

Interleukin-4

Phase 1, Phase 2

Antiviral Agents

Phase 1, Phase 2

Vitamin B Complex

Phase 1, Phase 2

Folic Acid Antagonists

Phase 1, Phase 2

Antirheumatic Agents

Phase 1, Phase 2

Immunoglobulins

Phase 1, Phase 2

Adjuvants, Immunologic

Phase 1, Phase 2

polysaccharide-K

Phase 1, Phase 2

Alkylating Agents

Phase 1, Phase 2

Anticonvulsants

Phase 1, Phase 2

Dermatologic Agents

Phase 1, Phase 2

Antifungal Agents

Phase 1, Phase 2

Antimetabolites, Antineoplastic

Phase 1, Phase 2

Hormones

Phase 1, Phase 2

Antineoplastic Agents, Alkylating

Phase 1, Phase 2

Calcium, Dietary

Phase 1, Phase 2

Folate

Phase 1, Phase 2

Mitogens

Phase 1, Phase 2

Diuretics, Potassium Sparing

Phase 1, Phase 2

Immunosuppressive Agents

Phase 1, Phase 2

Calcineurin Inhibitors

Phase 1, Phase 2

Interventional clinical trials:

(show all 32)

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Trial of Three Regimens to Prevent Tuberculosis in HIV-Infected Patients With Anergy	Completed	NCT00402610	Phase 4	isoniazid, rifampin + isoniazid, rifampin + pyrazinamide or not treatment
2	Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine	Completed	NCT02880865	Phase 4
3	Comparative Study of the Immunogenicity of MMR (Measles, Mumps and Rubella) Single Dose and Multidose Presentations	Completed	NCT01777529	Phase 4
4	Immunogenicity and Safety of Hepatitis A Vaccine Given at the Same Time of Measles, Mumps, Rubella Combined Vaccine	Completed	NCT00313950	Phase 4
5	Immunogenicity and Safety of Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases	Completed	NCT00126997	Phase 4
6	Safety & Immunogenicity Study of Meningococcal Vaccine GSK134612 Given With Priorix-Tetra™ to 12-23 Month-Old Children	Completed	NCT00474266	Phase 3
7	Safety and Immunogenicity Study of Live Attenuated Mumps Vaccines in Healthy Infants	Completed	NCT02692599	Phase 3
8	Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age	Completed	NCT02184572	Phase 3
9	Immunogenicity and Safety of GSK Biologicals' Combined Measles-mumps-rubella Vaccine in Volunteers, Seven Years of Age and Older	Completed	NCT02058563	Phase 3
10	Study of Immunogenicity, Reactogenicity and Safety of the Combined Measles, Mumps and Rubella Vaccine Produced by Bio-Manguinhos/Fiocruz in Children 12-15 Months of Age, Followed by Tetraviral Vaccine in Children 15-18 Months.	Completed	NCT01991899	Phase 3
11	Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life	Completed	NCT01681992	Phase 3
12	Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Subjects Four to Six Years of Age	Completed	NCT01621802	Phase 3
13	Safety, Tolerability, and Immunogenicity of Measles, Mumps, Rubella, and Varicella (MMRV) Vaccine Made With an Alternative Manufacturing Process (AMP)(V221-027)	Completed	NCT01536405	Phase 3
14	Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers	Completed	NCT01188343	Phase 3
15	Comparison of GSK Measles-mumps-rubella-varicella (MMRV) Vaccine Versus PriorixTM	Completed	NCT00969436	Phase 3
16	Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136	Completed	NCT00751348	Phase 3
17	Long-term Follow-up on Immunogenicity & Safety of Measles-Mumps-Rubella-Varicella (MMRV) Combined Vaccine	Completed	NCT00406211	Phase 3
18	Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases	Completed	NCT00127023	Phase 3
19	Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases	Completed	NCT00127010	Phase 3
20	Study to Evaluate Frozen Versus Refrigerated MMRV (Combined Measles, Mumps, Rubella, and Varicella) Investigational Vaccine (V221-016)	Completed	NCT00092430	Phase 3
21	A Study of An Approved Vaccine at Mumps Expiry Potency in Healthy Children 12 to 18 Months of Age (V205C-007)(COMPLETED)	Completed	NCT00092391	Phase 3
22	Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants	Unknown status	NCT03133923	Phase 2
23	Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer	Completed	NCT00245037	Phase 1, Phase 2	busulfan;cyclosporine;fludarabine phosphate;mycophenolate mofetil;Granulocyte colony-stimulating factor (G-CSF);Phenytoin;Methotrexate
24	Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™	Completed	NCT00353288	Phase 2
25	Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™	Completed	NCT00352898	Phase 2
26	A Phase I, Safety Study of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Children	Completed	NCT01712906	Phase 1
27	Gender and Opioid Consumption	Unknown status	NCT03006627	Not Applicable	postoperative morphine
28	Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome	Completed	NCT03157011	Not Applicable
29	Serological Study in Children 12 to 23 Months Vaccinated With MMR (Measles, Mumps and Rubella)	Completed	NCT01874457
30	Making Decisions About the Measles-Mumps-Rubella Vaccine	Completed	NCT01369394	Not Applicable
31	Measles, Mumps, and Rubella (MMR) Immunity in College Students	Completed	NCT00962819
32	Safety Study of Measles-Mumps-Rubella-Varicella (MMRV) Vaccine, Priorix-Tetra™ in Children Living in the Philippines	Withdrawn	NCT01738841

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

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Genetic Tests for Parotitis

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Anatomical Context for Parotitis

MalaCards organs/tissues related to Parotitis:

⁴²

Salivary Gland, Thyroid, Bone, Myeloid, Brain, Eye, Bone Marrow

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Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 661)

#	Title	Authors	Year
1	Juvenile Recurrent Parotitis. ( 30788670 )	Singh P...Gupta D	2019
2	Surgical Treatment of Chronic Parotitis. ( 30647789 )	van der Lans RJL...Quak JJ	2019
3	Could human bocavirus be a causative agent of parotitis in children? ( 29751940 )	Calvo C...M?ndez-Echevarr?a A	2019
4	Parotitis coexisting with Kawasaki disease in a child: a rare presentation of Kawasaki disease. ( 30898051 )	G?k?e ?...Ko? F	2019
5	Simultaneous parotitis and ipsilateral herpes zoster ophthalmicus: coincidence? ( 30898945 )	Banno F...Banno M	2019
6	Facial and limb angioedema with parotitis and Kikuchi-like necrotizing lymphadenitis preceding neuropsychiatric systemic lupus erythematosus in a young African American male. ( 28849689 )	Michailidou D...Dumitrescu M	2018
7	Non-mumps Viral Parotitis During the 2014-2015 Influenza Season in the United States. ( 29617951 )	Elbadawi LI...Davis JP	2018
8	Pediatric Primary Tuberculous Osteomyelitis of the Mandible Mimicking Parotitis. ( 29552433 )	Kalaiarasi R...Natarajan R	2018
9	The correlation of immunologic derangement and juvenile recurrent parotitis: an investigation of the laboratory immunological observation. ( 30702022 )	Wu S...Zheng L	2018
10	Role of Salivary Duct Morphology in the Etiology of Chronic Obstructive Parotitis: Statistical Analysis of Sialographic Features and Computational Fluid Dynamics Analysis of Salivary Flow. ( 30576669 )	Zhu W...Tao Q	2018
11	Juvenile recurrent parotitis: A systematic review of treatment studies. ( 30055724 )	Garavello W...Pignataro L	2018
12	Methicillin-Resistant Staphylococcus aureus Parotitis Leading to Mortality in an Adolescent Male. ( 29939841 )	Basinger JM...Fulcher JW	2018
13	Mucormycotic parotitis and otitis causing facial nerve palsy in a diabetic patient. ( 29904969 )	Gochhait D...Siddaraju N	2018
14	Acute Parotitis after Lower Limb Amputation: A Case Report of a Rare Complication. ( 29736287 )	Avgerinos KI...Bountouris I	2018
15	Is Parotitis One More Complication of Influenza? The Ongoing Challenge of Determining Causal Associations. ( 29617960 )	Pavia AT	2018
16	Influenza-Associated Parotitis During the 2014-2015 Influenza Season in the United States. ( 29617957 )	Rolfes MA...Jhung MA	2018
17	Sialoendoscopy for treatment of juvenile recurrent parotitis: The Brescia experience. ( 29447807 )	Berlucchi M...Redaelli De Zinis LO	2018
18	Mycobacterium mageritense Parotitis in an Immunocompetent Adult. ( 29434394 )	Okabe T...Morisawa Y	2018
19	Neonatal Parotitis. ( 29428272 )	Megged O...Baskin E	2018
20	Sialendoscopy in treatment of adult chronic recurrent parotitis without sialolithiasis. ( 29290052 )	Jokela J...Saarinen R	2018
21	Viral etiology of sporadic cases of parotitis among children in Korea during 2013-2014. ( 28876460 )	Kang HJ...Kim SS	2018
22	Acute parotitis due to MRSA causing Lemierre's syndrome. ( 29942528 )	Alabraba E...Sutton R	2018
23	Bruxism-induced parotitis: A retrospective case series analysis. ( 30048228 )	Teymoortash A...G?nzel T	2018
24	Magnetic Resonance Imaging Findings of Mumps Meningoencephalitis with Bilateral Hippocampal Lesions without Preceding Acute Parotitis: A Case Report. ( 28246518 )	Woo AR...Baek JH	2017
25	Concomitant Suppurative Parotitis and Condylar Osteomyelitis. ( 27717819 )	Vorrasi J...Zinberg G	2017
26	Eosinophilic sialodochitis: redefinition of 'allergic parotitis' and 'sialodochitis fibrinosa'. ( 27748012 )	Baer AN...Gniadek TJ	2017
27	Sialendoscopic Approach in Management of Juvenile Recurrent Parotitis. ( 29238673 )	Singh PP...Goyal A	2017
28	Challenging Case of Parotitis: A Comprehensive Approach. ( 29181524 )	Patel P...Cunningham S	2017
29	Ultrasound elastography in diagnosis and follow-up for patients with chronic recurrent parotitis. ( 28885206 )	Zengel P...Clevert DA	2017
30	Development of acute parotitis after non-invasive ventilation. ( 28840025 )	Martinez E...Dicpinigaitis PV	2017
31	An unusual case of acute parotitis in a young adult. ( 28742741 )	Sehic A...Spear F	2017
32	Sialoendoscopy combined with an internal stent and postoperative massage as a comprehensive treatment of delayed I131-induced parotitis. ( 28697989 )	Meng Q...Ke J	2017
33	Role of sialendoscopy in juvenile recurrent parotitis (JRP). ( 28669808 )	Berta E...Bettega G	2017
34	Core curriculum illustration: pediatric viral parotitis. ( 28593330 )	Pawley B...Kondaveeti R	2017
35	Chronic Recurrent Non-specific Parotitis: A Case Report and Review. ( 28458496 )	Mahalakshmi S...Kokila G	2017
36	Chymotrypsin with sialendoscopy-assisted surgery for the treatment of chronic obstructive parotitis. ( 28279602 )	Sun HJ...Zhou Q	2017
37	Erratum to: Pediatric suppurative parotitis caused by Burkholderia pseudomallei. ( 28138332 )	Fu Z...Xia Q	2017
38	Sialendoscopy-assisted treatment for chronic obstructive parotitis related to Sjogren syndrome. ( 28049607 )	Guo YF...Zhou Q	2017
39	Presentation of acute suppurative parotitis in a newborn with incessant crying. ( 27986789 )	Velkoski A...Travan L	2017
40	Chronic parotitis with multiple calcifications: Clinical and sialendoscopic findings. ( 27861944 )	J?uregui E...Chang JL	2017
41	Parotitis as an Initial Symptom of Kawasaki Disease. ( 28593063 )	Yokoyama K	2017
42	A case of neuromyelitis optica spectrum disorder (NMOSD) with Sjögren's syndrome manifested only brain involvement by preceding parotitis. ( 28132975 )	Furukawa T...Kaji R	2017
43	Complete genome sequence of mumps viruses isolated from patients with parotitis, pancreatitis and encephalitis in India. ( 26876221 )	Vaidya SR...Hamde VS	2016
44	A case of a male presenting with fever, parotitis, epididymo-orchitis, and kidney injury. ( 27012169 )	Wang Y...Deng B	2016
45	Tuberculous Lymphadenitis and Parotitis. ( 28084205 )	Cata?o JC...Robledo J	2016
46	Sialendoscopic treatment of recurrent juvenile parotitis: A South African case series. ( 27499410 )	Honnet S...Edkins O	2016
47	Botulinum Toxin for the Management of Sjögren Syndrome-Associated Recurrent Parotitis. ( 27400144 )	O'Neil LM...Mahant N	2016
48	Neonatal Suppurative Parotitis: Two Cases. ( 27351362 )	Tian X...Cheng W	2016
49	Diagnosing Juvenile Recurrent Parotitis. Case Reports. ( 26939156 )	Schorr B...Mandel L	2016
50	Acute Parotitis as a Complication of Noninvasive Ventilation. ( 26928643 )	Alaya S...Mrabet A	2016

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Genes for Parotitis

Genes related to Parotitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SPINK1	Serine Peptidase Inhibitor, Kazal Type 1	Protein Coding	27.05	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15753612 16303695
2	MMP2	Matrix Metallopeptidase 2	Protein Coding	20.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	MMP9	Matrix Metallopeptidase 9	Protein Coding	19.89	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	ALB	Albumin	Protein Coding	19.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	LTF	Lactotransferrin	Protein Coding	16.63	GeneCards inferred via : Publications (show sections)
6	G6PD	Glucose-6-Phosphate Dehydrogenase	Protein Coding	16.63	GeneCards inferred via : Publications (show sections)
7	CD79A	CD79a Molecule	Protein Coding	16.63	GeneCards inferred via : Publications (show sections)
8	H6PD	Hexose-6-Phosphate Dehydrogenase/Glucose 1-Dehydrogenase	Protein Coding	16.63	GeneCards inferred via : Publications (show sections)

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Variations for Parotitis

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Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

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Pathways for Parotitis

Pathways related to Parotitis according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	AGE/RAGE pathway ¹	11.33	MMP2 MMP9
2	LPA receptor mediated events ¹	11.31	MMP2 MMP9
3	Lung fibrosis ¹	11.28	MMP2 MMP9
4	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.26	MMP2 MMP9
5	Pentose phosphate pathway ³⁸ ¹ ¹ Show member pathways 5-Phosphoribose 1-diphosphate biosynthesis ⁶⁷ Insulin effects increased synthesis of Xylulose-5-Phosphate ⁶⁷ Pentose phosphate pathway (hexose monophosphate shunt) ⁶⁷ pentose phosphate pathway (non-oxidative branch) ¹ pentose phosphate pathway (oxidative branch) ¹ PRPP biosynthesis ¹	11.25	G6PD H6PD
6	Cell adhesion_ECM remodeling ²³	11.19	MMP2 MMP9
7	amb2 Integrin signaling ¹	11.05	MMP2 MMP9
8	Osteopontin-mediated events ¹ Show member pathways Osteopontin Signaling ¹	10.97	MMP2 MMP9
9	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ¹	10.79	MMP2 MMP9
10	A-beta Pathways: Uptake and Degradation ⁶⁶	10.66	MMP2 MMP9
11	Plasma membrane estrogen receptor signaling ¹	10.37	MMP2 MMP9
12	A-beta Pathways: Plaque Formation and APP Metabolism ⁶⁶	9.98	MMP2 MMP9

Sources

GO Terms for Parotitis

Cellular components related to Parotitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.55	ALB G6PD LTF MMP9 SPINK1
2	extracellular space	GO:0005615	9.02	ALB LTF MMP2 MMP9 SPINK1
3	tertiary granule lumen	GO:1904724	8.96	LTF MMP9

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	glucose metabolic process	GO:0006006	9.48	G6PD H6PD
2	extracellular matrix disassembly	GO:0022617	9.46	MMP2 MMP9
3	positive regulation of vascular smooth muscle cell proliferation	GO:1904707	9.43	MMP2 MMP9
4	embryo implantation	GO:0007566	9.4	MMP2 MMP9
5	retina homeostasis	GO:0001895	9.37	ALB LTF
6	cellular protein metabolic process	GO:0044267	9.33	ALB LTF MMP2
7	collagen catabolic process	GO:0030574	9.32	MMP2 MMP9
8	endodermal cell differentiation	GO:0035987	9.26	MMP2 MMP9
9	pentose-phosphate shunt	GO:0006098	8.96	G6PD H6PD
10	NADP metabolic process	GO:0006739	8.62	G6PD H6PD

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	NADP binding	GO:0050661	9.16	G6PD H6PD
2	serine-type endopeptidase activity	GO:0004252	9.13	LTF MMP2 MMP9
3	glucose-6-phosphate dehydrogenase activity	GO:0004345	8.62	G6PD H6PD

Sources

Sources for Parotitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia