Parotitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRT026 MIFTS: 45	Parotitis Categories: Endocrine diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Parotitis

MalaCards integrated aliases for Parotitis:

Name: Parotitis ¹² ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Oral diseases Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the digestive system

Diseases of oral cavity, salivary glands and jaws

Diseases of salivary glands

Sialoadenitis

External Ids:

Disease Ontology ¹² DOID:10301

ICD10 ³³ K11.2

MeSH ⁴⁴ D010309

NCIt ⁵⁰ C114281

SNOMED-CT ⁶⁸ 14756005

UMLS ⁷³ C0030583

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Summaries for Parotitis

Disease Ontology : ¹² A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary : Parotitis is related to meningoencephalitis and appendicitis. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are AGE/RAGE pathway and LPA receptor mediated events. The drugs Isoniazid and Pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and brain, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : ⁷⁶ Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

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Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)

#	Related Disease	Score	Top Affiliating Genes
1	meningoencephalitis	30.3	CD79A ALB
2	appendicitis	29.7	MMP9 ALB
3	parotitis, juvenile recurrent	12.1
4	mumps	10.5
5	orchitis	10.2
6	influenza	10.2
7	extracranial arteriovenous malformation	10.2	MMP9 MMP2
8	focal myositis	10.2	MMP9 MMP2
9	villous adenocarcinoma	10.2	MMP9 MMP2
10	lentigo maligna melanoma	10.2	MMP9 MMP2
11	spastic entropion	10.2	MMP9 MMP2
12	psammomatous meningioma	10.2	MMP9 MMP2
13	acute transverse myelitis	10.2	MMP9 MMP2
14	transverse myelitis	10.2	MMP9 MMP2
15	senile ectropion	10.2	MMP9 MMP2
16	internal hemorrhoid	10.2	MMP9 MMP2
17	light chain deposition disease	10.2	MMP9 MMP2
18	ischemic colitis	10.2	MMP9 MMP2
19	conjunctival nevus	10.2	MMP9 MMP2
20	corneal ulcer	10.2	MMP9 MMP2
21	odontogenic myxoma	10.2	MMP9 MMP2
22	nasal cavity squamous cell carcinoma	10.2	MMP9 MMP2
23	pancreatitis	10.2
24	laryngeal disease	10.1	MMP9 MMP2
25	hypertensive heart disease	10.1	MMP9 MMP2
26	pneumothorax	10.1	MMP9 MMP2
27	aortic aneurysm, familial thoracic 1	10.1	MMP9 MMP2
28	adenomyosis	10.1	MMP9 MMP2
29	skin melanoma	10.1	MMP9 MMP2
30	pancreas disease	10.1	SPINK1 ALB
31	chronic graft versus host disease	10.1	CD79A ALB
32	sjogren syndrome	10.1
33	pneumonia	10.1
34	grade iii astrocytoma	10.1	MMP9 MMP2
35	focal dermal hypoplasia	10.1	CD79A ALB
36	aortic disease	10.1	MMP9 MMP2
37	severe pre-eclampsia	10.1	MMP9 ALB
38	ulcerative stomatitis	10.1	CD79A ALB
39	bacterial meningitis	10.1	MMP9 ALB
40	protein-losing enteropathy	10.1	CD79A ALB
41	hypersensitivity reaction type iii disease	10.1	CD79A ALB
42	dysentery	10.1	LTF ALB
43	lipoid nephrosis	10.1	CD79A ALB
44	varicose veins	10.1	MMP9 MMP2
45	membranoproliferative glomerulonephritis	10.1	CD79A ALB
46	tongue cancer	10.1	MMP9 MMP2
47	leukemia	10.0
48	facial paralysis	10.0
49	lymphadenitis	10.0
50	meningitis	10.0

Graphical network of the top 20 diseases related to Parotitis:

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Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.63	CD79A G6PD LTF MMP2 MMP9 SPINK1
2	homeostasis/metabolism	MP:0005376	9.56	ALB CD79A G6PD H6PD LTF MMP2
3	neoplasm	MP:0002006	9.02	ALB CD79A LTF MMP2 MMP9

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Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Isoniazid

Approved, Investigational

Phase 4

54-85-3

3767

Pyrazinamide

Approved, Investigational

Phase 4

98-96-4

1046

Rifampicin

Approved

Phase 4

13292-46-1

5458213 5381226

Cytochrome P-450 CYP3A Inducers

Phase 4

Lipid Regulating Agents

Phase 4

Antimetabolites

Phase 4,Phase 1,Phase 2

Nucleic Acid Synthesis Inhibitors

Phase 4,Phase 1,Phase 2

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 1,Phase 2

Hypolipidemic Agents

Phase 4

Antitubercular Agents

Phase 4,Phase 1,Phase 2

Antibiotics, Antitubercular

Phase 4,Phase 1,Phase 2

Anti-Infective Agents

Phase 4,Phase 3,Phase 1,Phase 2

Immunologic Factors

Phase 4,Phase 3,Phase 1,Phase 2

Vaccines

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Tetracycline

Approved, Vet_approved

Phase 3

60-54-8

5353990

Heptavalent Pneumococcal Conjugate Vaccine

Phase 3

Fludarabine

Approved

Phase 1, Phase 2,Phase 2

75607-67-9, 21679-14-1

30751

leucovorin

Approved

Phase 1, Phase 2

58-05-9

6006 143

Miconazole

Approved, Investigational, Vet_approved

Phase 1, Phase 2

22916-47-8

4189

Lenograstim

Approved, Investigational

Phase 1, Phase 2

135968-09-1

Vidarabine

Approved, Investigational

Phase 1, Phase 2

24356-66-9

32326 21704

Mycophenolic acid

Approved

Phase 1, Phase 2

24280-93-1

446541

Methotrexate

Approved

Phase 1, Phase 2

59-05-2, 1959-05-2

126941

Busulfan

Approved, Investigational

Phase 1, Phase 2

55-98-1

2478

Phenytoin

Approved, Vet_approved

Phase 1, Phase 2

57-41-0

1775

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 1, Phase 2

59-30-3

6037

Calcium, Dietary

Phase 1, Phase 2

Antibodies

Phase 1, Phase 2

Antimetabolites, Antineoplastic

Phase 1, Phase 2

Antineoplastic Agents, Alkylating

Phase 1, Phase 2

Calcineurin Inhibitors

Phase 1, Phase 2

Adjuvants, Immunologic

Phase 1, Phase 2

Antiviral Agents

Phase 1, Phase 2

Cyclosporins

Phase 1, Phase 2

Interleukin-4

Phase 1, Phase 2

Mitogens

Phase 1, Phase 2

Alkylating Agents

Phase 1, Phase 2

Vitamin B9

Phase 1, Phase 2

Vitamin B Complex

Phase 1, Phase 2

Diuretics, Potassium Sparing

Phase 1, Phase 2

Immunosuppressive Agents

Phase 1, Phase 2

Folic Acid Antagonists

Phase 1, Phase 2

Anticonvulsants

Phase 1, Phase 2

Antifungal Agents

Phase 1, Phase 2

Sodium Channel Blockers

Phase 1, Phase 2

Hormones

Phase 1, Phase 2

Krestin

Phase 1, Phase 2

Interleukin-2

Phase 1, Phase 2

Folate

Phase 1, Phase 2

Antirheumatic Agents

Phase 1, Phase 2

Interventional clinical trials:

(show all 32)

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Trial of Three Regimens to Prevent Tuberculosis in HIV-Infected Patients With Anergy	Completed	NCT00402610	Phase 4	isoniazid, rifampin + isoniazid, rifampin + pyrazinamide or not treatment
2	Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine	Completed	NCT02880865	Phase 4
3	Comparative Study of the Immunogenicity of MMR (Measles, Mumps and Rubella) Single Dose and Multidose Presentations	Completed	NCT01777529	Phase 4
4	Immunogenicity and Safety of Hepatitis A Vaccine Given at the Same Time of Measles, Mumps, Rubella Combined Vaccine	Completed	NCT00313950	Phase 4
5	Immunogenicity and Safety of Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases	Completed	NCT00126997	Phase 4
6	Safety & Immunogenicity Study of Meningococcal Vaccine GSK134612 Given With Priorix-Tetra™ to 12-23 Month-Old Children	Completed	NCT00474266	Phase 3
7	Safety and Immunogenicity Study of Live Attenuated Mumps Vaccines in Healthy Infants	Completed	NCT02692599	Phase 3
8	Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age	Completed	NCT02184572	Phase 3
9	Immunogenicity and Safety of GSK Biologicals' Combined Measles-mumps-rubella Vaccine in Volunteers, Seven Years of Age and Older	Completed	NCT02058563	Phase 3
10	Study of Immunogenicity, Reactogenicity and Safety of the Combined Measles, Mumps and Rubella Vaccine Produced by Bio-Manguinhos/Fiocruz in Children 12-15 Months of Age, Followed by Tetraviral Vaccine in Children 15-18 Months.	Completed	NCT01991899	Phase 3
11	Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life	Completed	NCT01681992	Phase 3
12	Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Subjects Four to Six Years of Age	Completed	NCT01621802	Phase 3
13	Safety, Tolerability, and Immunogenicity of Measles, Mumps, Rubella, and Varicella (MMRV) Vaccine Made With an Alternative Manufacturing Process (AMP)(V221-027)	Completed	NCT01536405	Phase 3
14	Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers	Completed	NCT01188343	Phase 3
15	Comparison of GSK Measles-mumps-rubella-varicella (MMRV) Vaccine Versus PriorixTM	Completed	NCT00969436	Phase 3
16	Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136	Completed	NCT00751348	Phase 3
17	Long-term Follow-up on Immunogenicity & Safety of Measles-Mumps-Rubella-Varicella (MMRV) Combined Vaccine	Completed	NCT00406211	Phase 3
18	Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases	Completed	NCT00127023	Phase 3
19	Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases	Completed	NCT00127010	Phase 3
20	Study to Evaluate Frozen Versus Refrigerated MMRV (Combined Measles, Mumps, Rubella, and Varicella) Investigational Vaccine (V221-016)	Completed	NCT00092430	Phase 3
21	A Study of An Approved Vaccine at Mumps Expiry Potency in Healthy Children 12 to 18 Months of Age (V205C-007)(COMPLETED)	Completed	NCT00092391	Phase 3
22	Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer	Completed	NCT00245037	Phase 1, Phase 2	busulfan;cyclosporine;fludarabine phosphate;mycophenolate mofetil;Granulocyte colony-stimulating factor (G-CSF);Phenytoin;Methotrexate
23	Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™	Completed	NCT00353288	Phase 2
24	Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™	Completed	NCT00352898	Phase 2
25	Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants	Active, not recruiting	NCT03133923	Phase 2
26	A Phase I, Safety Study of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Children	Completed	NCT01712906	Phase 1
27	Gender and Opioid Consumption	Unknown status	NCT03006627	Not Applicable	postoperative morphine
28	Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome	Completed	NCT03157011	Not Applicable
29	Serological Study in Children 12 to 23 Months Vaccinated With MMR (Measles, Mumps and Rubella)	Completed	NCT01874457
30	Making Decisions About the Measles-Mumps-Rubella Vaccine	Completed	NCT01369394	Not Applicable
31	Measles, Mumps, and Rubella (MMR) Immunity in College Students	Completed	NCT00962819
32	Safety Study of Measles-Mumps-Rubella-Varicella (MMRV) Vaccine, Priorix-Tetra™ in Children Living in the Philippines	Withdrawn	NCT01738841

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

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Genetic Tests for Parotitis

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Anatomical Context for Parotitis

MalaCards organs/tissues related to Parotitis:

⁴¹

Salivary Gland, Thyroid, Brain, Myeloid, Skin, Heart, Pancreas

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Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 654)

#	Title	Authors	Year
1	Neonatal Parotitis. ( 29428272 )	Megged O....Baskin E.	2018
2	Could human bocavirus be a causative agent of parotitis in children? ( 29751940 )	Calvo C....MAcndez-EchevarrA-a A.	2018
3	Mucormycotic parotitis and otitis causing facial nerve palsy in a diabetic patient. ( 29904969 )	Gochhait D....Siddaraju N.	2018
4	Non-mumps Viral Parotitis During the 2014-2015 Influenza Season in the United States. ( 29617951 )	Elbadawi L.I....Davis J.P.	2018
5	<i>Mycobacterium mageritense</i> Parotitis in an Immunocompetent Adult. ( 29434394 )	Okabe T....Morisawa Y.	2018
6	Sialendoscopy in treatment of adult chronic recurrent parotitis without sialolithiasis. ( 29290052 )	Jokela J....Saarinen R.	2018
7	Is Parotitis One More Complication of Influenza? The Ongoing Challenge of Determining Causal Associations. ( 29617960 )		2018
8	Methicillin-Resistant Staphylococcus aureus Parotitis Leading to Mortality in an Adolescent Male. ( 29939841 )		2018
9	Acute parotitis due to MRSA causing Lemierre's syndrome. ( 29942528 )		2018
10	Influenza-Associated Parotitis During the 2014-2015 Influenza Season in the United States. ( 29617957 )		2018
11	Acute Parotitis after Lower Limb Amputation: A Case Report of a Rare Complication. ( 29736287 )		2018
12	Pediatric Primary Tuberculous Osteomyelitis of the Mandible Mimicking Parotitis. ( 29552433 )		2018
13	Sialoendoscopy for treatment of juvenile recurrent parotitis: The Brescia experience. ( 29447807 )		2018
14	Bruxism-induced parotitis: A retrospective case series analysis. ( 30048228 )	Teymoortash A...G?nzel T	2018
15	Juvenile recurrent parotitis: A systematic review of treatment studies. ( 30055724 )	Garavello W...Pignataro L	2018
16	Role of sialendoscopy in juvenile recurrent parotitis (JRP). ( 28669808 )	Berta E....Bettega G.	2017
17	Viral etiology of sporadic cases of parotitis among children in Korea during 2013-2014. ( 28876460 )	Kang H.J....Kim S.S.	2017
18	Challenging Case of Parotitis: A Comprehensive Approach. ( 29181524 )	Patel P....Cunningham S.	2017
19	Chronic Recurrent Non-specific Parotitis: A Case Report and Review. ( 28458496 )	Mahalakshmi S....Kokila G.	2017
20	Sialoendoscopy combined with an internal stent and postoperative massage as a comprehensive treatment of delayed I(131)-induced parotitis. ( 28697989 )	Meng Q....Ke J.	2017
21	Sialendoscopic Approach in Management of Juvenile Recurrent Parotitis. ( 29238673 )	Singh P.P....Goyal A.	2017
22	Magnetic Resonance Imaging Findings of Mumps Meningoencephalitis with Bilateral Hippocampal Lesions without Preceding Acute Parotitis: A Case Report. ( 28246518 )	Woo A.R....Baek J.H.	2017
23	Parotitis as an Initial Symptom of Kawasaki Disease. ( 28593063 )		2017
24	Development of acute parotitis after non-invasive ventilation. ( 28840025 )		2017
25	An unusual case of acute parotitis in a young adult. ( 28742741 )		2017
26	A case of neuromyelitis optica spectrum disorder (NMOSD) with SjAPgren's syndrome manifested only brain involvement by preceding parotitis. ( 28132975 )		2017
27	Facial and limb angioedema with parotitis and Kikuchi-like necrotizing lymphadenitis preceding neuropsychiatric systemic lupus erythematosus in a young African American male. ( 28849689 )		2017
28	Core curriculum illustration: pediatric viral parotitis. ( 28593330 )		2017
29	Chymotrypsin with sialendoscopy-assisted surgery for the treatment of chronic obstructive parotitis. ( 28279602 )		2017
30	Erratum to: Pediatric suppurative parotitis caused by Burkholderia pseudomallei. ( 28138332 )	Fu Z...Xia Q	2017
31	Ultrasound elastography in diagnosis and follow-up for patients with chronic recurrent parotitis. ( 28885206 )	Zengel P...Clevert DA	2017
32	Role of the Accessory Parotid Gland in the Etiology of Parotitis: Statistical Analysis of Sialographic Features. ( 26913509 )	Zhu W....Tao Q.	2016
33	Concomitant Suppurative Parotitis and Condylar Osteomyelitis. ( 27717819 )	Vorrasi J....Zinberg G.	2016
34	Eosinophilic sialodochitis: redefinition of 'allergic parotitis' and 'sialodochitis fibrinosa'. ( 27748012 )	Baer A.N....Gniadek T.J.	2016
35	Acute Parotitis as a Complication of Noninvasive Ventilation. ( 26928643 )	Alaya S....Mrabet A.	2016
36	Streptococcus pneumoniae bacteraemia due to parotitis in a patient with systemic sclerosis and secondary SjAPgren's syndrome. ( 28348790 )	Yii I.Y....Fong W.W.	2016
37	Sialendoscopy-assisted treatment for chronic obstructive parotitis related to Sjogren syndrome. ( 28049607 )	Guo Y.F....Zhou Q.	2016
38	Bilateral parotitis in a patient under continuous positive airway pressure treatment. ( 27793244 )	Abdullayev R....Akgun S.	2016
39	Pediatric suppurative parotitis caused by Burkholderia pseudomallei. ( 27843446 )	Fu Z....Xia Q.	2016
40	Diagnosing Juvenile Recurrent Parotitis. Case Reports. ( 26939156 )	Schorr B....Mandel L.	2016
41	Tuberculous Lymphadenitis and Parotitis. ( 28084205 )	CataA+o J.C....Robledo J.	2016
42	Parotitis and Sialendoscopy of the Parotid Gland. ( 26912292 )	Hernandez S....Walvekar R.R.	2016
43	Sialendoscopic treatment of recurrent juvenile parotitis: A South African case series. ( 27499410 )	Honnet S....Edkins O.	2016
44	Function of the parotid gland in juvenile recurrent parotitis: a case series. ( 26852271 )	Xie L.S....Shi H.	2016
45	Presentation of acute suppurative parotitis in a newborn with incessant crying. ( 27986789 )		2016
46	Neonatal Suppurative Parotitis: Two Cases. ( 27351362 )		2016
47	Decreased salivary matrix metalloproteinase-8 reflecting a defensive potential in juvenile parotitis. ( 26746616 )		2016
48	A case of a male presenting with fever, parotitis, epididymo-orchitis, and kidney injury. ( 27012169 )		2016
49	Chronic parotitis with multiple calcifications: Clinical and sialendoscopic findings. ( 27861944 )		2016
50	Botulinum Toxin for the Management of SjAPgren Syndrome-Associated Recurrent Parotitis. ( 27400144 )		2016

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Genes for Parotitis

Genes related to Parotitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SPINK1	Serine Peptidase Inhibitor, Kazal Type 1	Protein Coding	27.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15753612 16303695
2	MMP2	Matrix Metallopeptidase 2	Protein Coding	20.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	MMP9	Matrix Metallopeptidase 9	Protein Coding	19.88	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	ALB	Albumin	Protein Coding	19.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	CD79A	CD79a Molecule	Protein Coding	16.62	GeneCards inferred via : Publications (show sections)
6	G6PD	Glucose-6-Phosphate Dehydrogenase	Protein Coding	16.62	GeneCards inferred via : Publications (show sections)
7	H6PD	Hexose-6-Phosphate Dehydrogenase/Glucose 1-Dehydrogenase	Protein Coding	16.62	GeneCards inferred via : Publications (show sections)
8	LTF	Lactotransferrin	Protein Coding	16.62	GeneCards inferred via : Publications (show sections)

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Variations for Parotitis

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Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

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Pathways for Parotitis

Pathways related to Parotitis according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	AGE/RAGE pathway ¹	11.33	MMP2 MMP9
2	LPA receptor mediated events ¹	11.31	MMP2 MMP9
3	Pentose phosphate pathway ¹ ³⁷ ¹ Show member pathways 5-Phosphoribose 1-diphosphate biosynthesis ⁶⁶ Insulin effects increased synthesis of Xylulose-5-Phosphate ⁶⁶ Pentose phosphate pathway (hexose monophosphate shunt) ⁶⁶ pentose phosphate pathway (non-oxidative branch) ¹ pentose phosphate pathway (oxidative branch) ¹ PRPP biosynthesis ¹	11.29	G6PD H6PD
4	Lung fibrosis ¹	11.26	MMP2 MMP9
5	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.23	MMP2 MMP9
6	Cell adhesion_ECM remodeling ²²	11.19	MMP2 MMP9
7	amb2 Integrin signaling ¹	11.05	MMP2 MMP9
8	Osteopontin-mediated events ¹ Show member pathways Osteopontin Signaling ¹	10.97	MMP2 MMP9
9	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ¹	10.79	MMP2 MMP9
10	A-beta Pathways: Uptake and Degradation ⁶⁵	10.66	MMP2 MMP9
11	Plasma membrane estrogen receptor signaling ¹	10.37	MMP2 MMP9
12	A-beta Pathways: Plaque Formation and APP Metabolism ⁶⁵	9.98	MMP2 MMP9

Sources

GO Terms for Parotitis

Cellular components related to Parotitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.55	ALB G6PD LTF MMP9 SPINK1
2	extracellular space	GO:0005615	9.02	ALB LTF MMP2 MMP9 SPINK1
3	tertiary granule lumen	GO:1904724	8.96	LTF MMP9

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	glucose metabolic process	GO:0006006	9.48	G6PD H6PD
2	extracellular matrix disassembly	GO:0022617	9.46	MMP2 MMP9
3	positive regulation of vascular smooth muscle cell proliferation	GO:1904707	9.43	MMP2 MMP9
4	embryo implantation	GO:0007566	9.4	MMP2 MMP9
5	retina homeostasis	GO:0001895	9.37	ALB LTF
6	cellular protein metabolic process	GO:0044267	9.33	ALB LTF MMP2
7	collagen catabolic process	GO:0030574	9.32	MMP2 MMP9
8	endodermal cell differentiation	GO:0035987	9.26	MMP2 MMP9
9	pentose-phosphate shunt	GO:0006098	8.96	G6PD H6PD
10	NADP metabolic process	GO:0006739	8.62	G6PD H6PD

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	NADP binding	GO:0050661	9.16	G6PD H6PD
2	serine-type endopeptidase activity	GO:0004252	9.13	LTF MMP2 MMP9
3	glucose-6-phosphate dehydrogenase activity	GO:0004345	8.62	G6PD H6PD

Sources

Sources for Parotitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia