MCID: PRT026
MIFTS: 42

Parotitis

Categories: Endocrine diseases, Oral diseases

Aliases & Classifications for Parotitis

MalaCards integrated aliases for Parotitis:

Name: Parotitis 12 54 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10301
NCIt 49 C114281
SNOMED-CT 67 14756005
ICD10 32 K11.2
UMLS 71 C0030583

Summaries for Parotitis

Disease Ontology : 12 A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary : Parotitis is related to meningitis and acute pancreatitis. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor Kazal Type 1), and among its related pathways/superpathways are Photodynamic therapy-induced NF-kB survival signaling and Primary immunodeficiency. The drugs Oseltamivir and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, testes and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 573)
# Related Disease Score Top Affiliating Genes
1 meningitis 30.7 MMP9 CRP CD40LG ALB
2 acute pancreatitis 30.6 SPINK1 CRP ALB
3 orchitis 30.5 CRP CD40LG CD4
4 purpura 30.4 CRP CD79A CD40LG
5 pneumonia 30.2 MMP9 CRP CD40LG ALB
6 keratoconjunctivitis 30.2 TRIM21 MMP9 ALB
7 scarlet fever 30.1 CRP CD40LG ALB
8 thrombophlebitis 30.1 CRP CD40LG ALB
9 mediastinitis 30.1 CRP ALB
10 facial paralysis 30.1 CRP CD40LG CD4 ALB
11 immunoglobulin alpha deficiency 30.0 CD79A CD40LG CD4
12 sialadenitis 30.0 TRIM21 SSB MMP2 CD4
13 chickenpox 30.0 CRP CD40LG CD4 ALB
14 lipoid nephrosis 30.0 CD79A CD40LG ALB
15 guillain-barre syndrome 30.0 CD79A CD40LG ALB
16 epiglottitis 30.0 CRP CD40LG
17 appendicitis 30.0 MMP9 CRP ALB
18 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 30.0 G6PD CRP ALB
19 herpes zoster 30.0 CRP CD40LG CD4
20 cellulitis 29.9 CRP CD40LG CD4
21 meningoencephalitis 29.9 CRP CD79A CD40LG CD4 ALB
22 vasculitis 29.9 LTF CRP CD79A CD40LG
23 pyuria 29.9 CRP CD40LG ALB
24 paralytic ileus 29.9 CRP ALB
25 periodontitis 29.9 MMP9 MMP2 CRP
26 typhoid fever 29.8 CRP CD40LG ALB
27 cervical adenitis 29.8 CRP CD40LG CD4
28 lyme disease 29.8 MMP9 CRP CD40LG
29 autoimmune disease 29.7 TRIM21 MMP9 CRP CD79A CD40LG
30 secondary syphilis 29.6 CD79A CD40LG CD4
31 actinomycosis 29.6 CRP CD4 ALB
32 extrapulmonary tuberculosis 29.6 CRP CD4 ALB
33 anemia, autoimmune hemolytic 29.6 G6PD CD40LG CD4
34 otitis media 29.6 CRP CD79A CD40LG ALB
35 kawasaki disease 29.6 MMP9 CRP CD40LG CD4 ALB
36 deficiency anemia 29.6 LTF G6PD CRP ALB
37 immunoglobulin a deficiency 1 29.5 CD79A CD40LG
38 sjogren syndrome 29.5 TRIM21 SSB LTF CD79A CD40LG
39 pulmonary disease, chronic obstructive 29.5 MMP9 CRP CD4 ALB
40 iridocyclitis 29.5 CRP CD40LG CD4
41 severe cutaneous adverse reaction 29.4 CRP CD40LG CD4
42 blastomycosis 29.4 CD40LG CD4
43 amebiasis 29.4 CD79A CD40LG CD4 ALB
44 bacterial infectious disease 29.3 LTF CRP CD40LG CD4
45 bronchitis 29.2 MMP9 LTF CRP CD40LG ALB
46 pharyngitis 29.2 CRP CD40LG CD4 ALB
47 dysentery 29.2 CRP CD40LG CD4 ALB
48 pericarditis 29.2 CRP CD40LG CD4 ALB
49 syphilis 29.1 CRP CD79A CD40LG CD4 ALB
50 exanthem 29.1 TRIM21 CRP CD40LG CD4 ALB

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to Parotitis

Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 CD4 CD40LG CD79A G6PD L3MBTL1 LTF
2 homeostasis/metabolism MP:0005376 9.97 ALB CD4 CD40LG CD79A CRP G6PD
3 immune system MP:0005387 9.73 ALB CD4 CD40LG CD79A CRP L3MBTL1
4 mortality/aging MP:0010768 9.4 ALB CD4 CD40LG CD79A G6PD KLK4

Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oseltamivir Approved Phase 4 204255-11-8, 196618-13-0 65028
2 Antiviral Agents Phase 4
3
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
4
leucovorin Approved Phase 1, Phase 2 58-05-9 6006 143
5
Methotrexate Approved Phase 1, Phase 2 59-05-2, 1959-05-2 126941
6
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
7
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
8
Vidarabine Approved, Investigational Phase 1, Phase 2 24356-66-9 21704 32326
9
Sargramostim Approved, Investigational Phase 1, Phase 2 83869-56-1, 123774-72-1
10
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
11
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
12
Phenytoin Approved, Vet_approved Phase 1, Phase 2 57-41-0 1775
13
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
14
Altretamine Approved Phase 1, Phase 2 645-05-6 2123
15
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
16 Molgramostim Investigational Phase 1, Phase 2 99283-10-0
17 Vaccines Phase 2
18 Immunologic Factors Phase 1, Phase 2
19 Anti-Infective Agents Phase 1, Phase 2
20 Immunoglobulins Phase 1, Phase 2
21 Sodium Channel Blockers Phase 1, Phase 2
22 Antitubercular Agents Phase 1, Phase 2
23 Antibodies Phase 1, Phase 2
24 Hormones Phase 1, Phase 2
25 Adjuvants, Immunologic Phase 1, Phase 2
26 Mitogens Phase 1, Phase 2
27 Interleukin-2 Phase 1, Phase 2
28 Vitamin B Complex Phase 1, Phase 2
29 Folic Acid Antagonists Phase 1, Phase 2
30 Immunosuppressive Agents Phase 1, Phase 2
31 Anti-Bacterial Agents Phase 1, Phase 2
32 Folate Phase 1, Phase 2
33 Alkylating Agents Phase 1, Phase 2
34 Cyclosporins Phase 1, Phase 2
35 Interleukin-4 Phase 1, Phase 2
36 Antifungal Agents Phase 1, Phase 2
37 Anticonvulsants Phase 1, Phase 2
38 Calcineurin Inhibitors Phase 1, Phase 2
39 Calcium, Dietary Phase 1, Phase 2
40 Antibiotics, Antitubercular Phase 1, Phase 2
41 Antimetabolites Phase 1, Phase 2
42 Dermatologic Agents Phase 1, Phase 2
43 Diuretics, Potassium Sparing Phase 1, Phase 2
44 polysaccharide-K Phase 1, Phase 2
45 Vitamin B9 Phase 1, Phase 2
46 Antirheumatic Agents Phase 1, Phase 2
47
Calcium Nutraceutical Phase 1, Phase 2 7440-70-2 271
48
Morphine Approved, Investigational 57-27-2 5288826
49 Narcotics
50 Analgesics, Opioid

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
2 Safety and Efficacy of Attenuated Mumps Vaccine (Human Diploid Cell) Unknown status NCT03133923 Phase 2
3 A Phase I/II Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplant for the Treatment of Patients With Hematologic Malignancies Using Busulfan, Fludarabine and Total Body Irradiation Completed NCT00245037 Phase 1, Phase 2 busulfan;cyclosporine;fludarabine phosphate;mycophenolate mofetil;Granulocyte colony-stimulating factor (G-CSF);Phenytoin;Methotrexate
4 Transplantation of Expanded and Unexpanded Umbilical Cord Blood Units Following Myeloablative Chemotherapy for Hematologic Malignancies Terminated NCT00539656 Phase 1, Phase 2
5 Gender and Opioid Consumption Unknown status NCT03006627 postoperative morphine
6 Treatment of Juvenile Recurrent Parotitis: the Yield of Minimally Invasive Intervention, a Prospective Controlled Study Not yet recruiting NCT04074694

Search NIH Clinical Center for Parotitis

Genetic Tests for Parotitis

Anatomical Context for Parotitis

MalaCards organs/tissues related to Parotitis:

40
Salivary Gland, Testes, Bone, Pancreas, Thyroid, Bone Marrow, Brain

Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 2114)
# Title Authors PMID Year
1
New insights into juvenile parotitis. 54 61
16303695 2005
2
Chronic parotitis: not another SPINKosis. 61 54
15753612 2004
3
Neonatal Acute Suppurative Parotitis. 61
32476464 2020
4
Parotitis-Like Symptoms Associated with COVID-19, France, March-April 2020. 61
32491984 2020
5
[Cervicofacial cellulitis complicated by internal jugular vein thrombosis]. 61
32505376 2020
6
Parotitis due to Burkholderia cepacia Infection after Autologous Hematopoietic Stem Cell Transplantation. 61
32564412 2020
7
Acute on chronic parotitis causing osteomyelitis and pathological fracture of the mandible. 61
32532905 2020
8
Identification and description of mumps cases in a non-outbreak setting and evaluation of the effectiveness of mumps-containing vaccines over time. 61
32401599 2020
9
Acute Parotitis: A Possible Precocious Clinical Manifestation of SARS-CoV-2 Infection? 61
32369434 2020
10
Acute Candida glabrata Parotitis with Fungemia after Major Pelvic Oncologic Surgical Procedure. 61
32466720 2020
11
The Accessory Parotid Gland and its Clinical Significance. 61
31856138 2020
12
Long-Term Results of a Pedicled and Innervated Sternocleidomastoid Muscle Flap to Immediately Reconstruct Superficial Parotidectomy Defects. 61
32456521 2020
13
Juvenile recurrent parotitis: Soft foods contribute to the delayed development of salivary glands. 61
31828830 2020
14
L-asparaginase-induced Parotitis in an Elderly Patient with Acute Lymphoblastic Leukemia. 61
32296003 2020
15
Parotitis on Ultrasound: The Pomegranate Sign. 61
32195979 2020
16
Pediatric sialendoscopy: An 11-year study from a single tertiary care center. 61
31972384 2020
17
Single-photon emission computed tomography/computed tomography for evaluation of salivary gland dysfunction: preliminary study on diagnostic ability of maximum standardized uptake value. 61
31201645 2020
18
A 13-Year-Old Boy Who Has Kawasaki Disease Shock Syndrome Presents with Parotitis. 61
31984160 2020
19
Mumps: an Update on Outbreaks, Vaccine Efficacy, and Genomic Diversity. 61
32102901 2020
20
Bruxism-induced parotitis: A retrospective case series analysis. 61
30048228 2020
21
Doxorubicin and cyclophosphamide-induced parotitis: A case report. 61
31539173 2020
22
Sjögren's syndrome in children with recurrent parotitis. 61
31731017 2020
23
Parotitis After Endoscopic Retrograde Cholangiopancreatography. 61
32309499 2020
24
Acute Hydrocephalus in a Case of Mumps Meningoencephalitis: A Rare Occurrence. 61
32435304 2020
25
Patient Delay in Hospital Visiting and the Weekend Effect of Surveillance Report on Hand-Foot-and-Mouth Disease and Epidemic Parotitis in Hanzhong City, China. 61
32454917 2020
26
Botulism disguised as parotitis. 61
32509528 2020
27
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in the oromaxillofacial head and neck region: A retrospective analysis of 105 patients. 61
31733094 2020
28
Juvenile Sjögren's Syndrome: Clinical Characteristics With Focus on Salivary Gland Ultrasonography. 61
30697959 2020
29
Late onset group B streptococcus disease manifesting as acute suppurative parotitis. 61
32461904 2020
30
Tuberculosis as a Cause of Rapid Salivary Gland Swelling in the Elderly - A Case Report. 61
32206647 2020
31
Salivary Gland Disorders in Children and Adolescents: A 15-year Experience. 61
31929831 2020
32
Anti-cancer effects of Polyphyllin I: An update in 5 years. 61
31870841 2020
33
Mumps encephalitis with bilateral hippocampal lesions preceding parotitis. 61
32042482 2019
34
Parotitis: An Initial Manifestation of Kawasaki Disease. 61
31378519 2019
35
Bilateral parotitis following doxycycline use. 61
31409734 2019
36
[Neonatal suppurative parotitis]. 61
31794049 2019
37
Influenza A-associated parotitis in a 5-year-old boy. 61
31721373 2019
38
Correction to: Core curriculum illustration: pediatric viral parotitis. 61
31254237 2019
39
Intra-auricular modification of facelift incision decreased the risk of Frey syndrome. 61
31867256 2019
40
Severe idiopathic pneumoparotitis: Case report and study review. 61
31374539 2019
41
Evaluation of Outcomes following Radiofrequency Ablation for Treatment of Parotid Tail Warthin Tumors. 61
31471194 2019
42
Juvenile recurrent parotitis: Diagnostic and therapeutic effectiveness of sialography. Retrospective study on 110 children. 61
31202035 2019
43
Mumps outbreak and MMR IgG surveillance as a predictor for immunity in military trainees. 61
31493948 2019
44
[Parotitis and influenza: unusual association during 2017, in Santa Fe, Argentina]. 61
31859767 2019
45
Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps Virus. 61
31118251 2019
46
Juvenile Recurrent Parotitis. 61
30788670 2019
47
Parotitis coexisting with Kawasaki disease in a child: a rare presentation of Kawasaki disease. 61
30898051 2019
48
Post-mumps acute disseminated encephalomyelitis in an adolescent. 61
31463290 2019
49
Core curriculum illustration: pediatric viral parotitis. 61
28593330 2019
50
Influenza-Related Parotitis during a Large Mumps Outbreak - Arkansas, 2016-2017. 61
32337511 2019

Variations for Parotitis

Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for Parotitis

Pathways related to Parotitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 MMP9 MMP2 CD40LG
2 10.71 CD79A CD40LG CD4
3 10.3 MMP9 MMP2 CD40LG

GO Terms for Parotitis

Cellular components related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 SPINK1 MMP9 MMP2 LTF CRP CD40LG
2 extracellular region GO:0005576 9.23 SPINK1 MMP9 MMP2 LTF KLK4 CRP

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to amyloid-beta GO:1904645 9.37 MMP9 MMP2
2 extracellular matrix disassembly GO:0022617 9.33 MMP9 MMP2 KLK4
3 pentose-phosphate shunt GO:0006098 9.32 H6PD G6PD
4 positive regulation of viral entry into host cell GO:0046598 9.26 TRIM21 CD4
5 negative regulation by host of viral process GO:0044793 8.96 LTF CRP
6 pentose-phosphate shunt, oxidative branch GO:0009051 8.62 H6PD G6PD

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.8 TRIM21 MMP9 MMP2 L3MBTL1 CD4 ALB
2 serine-type endopeptidase activity GO:0004252 9.56 MMP9 MMP2 LTF KLK4
3 identical protein binding GO:0042802 9.23 TRIM21 MMP9 L3MBTL1 G6PD CRP CD79A
4 oxidoreductase activity, acting on CH-OH group of donors GO:0016614 9.16 H6PD G6PD
5 glucose-6-phosphate dehydrogenase activity GO:0004345 8.96 H6PD G6PD

Sources for Parotitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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