MCID: PRT026
MIFTS: 43

Parotitis

Categories: Endocrine diseases, Oral diseases

Aliases & Classifications for Parotitis

MalaCards integrated aliases for Parotitis:

Name: Parotitis 12 55 44 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:10301
MeSH 44 D010309
NCIt 50 C114281
SNOMED-CT 68 14756005
ICD10 33 K11.2
UMLS 72 C0030583

Summaries for Parotitis

Disease Ontology : 12 A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary : Parotitis is related to meningitis and meningoencephalitis. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Bladder cancer. The drugs Oseltamivir and Sargramostim have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, testes and bone, and related phenotypes are homeostasis/metabolism and neoplasm

Wikipedia : 75 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 292)
# Related Disease Score Top Affiliating Genes
1 meningitis 30.9 MMP9 ALB
2 meningoencephalitis 30.7 CD79A ALB
3 newcastle disease 30.3 MMP9 MMP2
4 keratoconjunctivitis sicca 29.9 CD79A ALB
5 appendicitis 29.9 MMP9 ALB
6 lipoid nephrosis 29.7 CD79A ALB
7 guillain-barre syndrome 29.7 CD79A ALB
8 kawasaki disease 29.5 MMP9 ALB
9 otitis media 29.4 CD79A ALB
10 periodontitis 29.4 MMP9 MMP2
11 parotitis, juvenile recurrent 12.4
12 lemierre's syndrome 11.6
13 mumps 10.8
14 sialadenitis 10.5
15 measles 10.5
16 orchitis 10.5
17 pancreatitis 10.4
18 rubella 10.4
19 extracranial arteriovenous malformation 10.4 MMP9 MMP2
20 focal myositis 10.4 MMP9 MMP2
21 villous adenocarcinoma 10.4 MMP9 MMP2
22 encephalitis 10.4
23 lentigo maligna melanoma 10.4 MMP9 MMP2
24 spastic entropion 10.4 MMP9 MMP2
25 psammomatous meningioma 10.4 MMP9 MMP2
26 acute transverse myelitis 10.4 MMP9 MMP2
27 transverse myelitis 10.4 MMP9 MMP2
28 senile ectropion 10.4 MMP9 MMP2
29 internal hemorrhoid 10.3 MMP9 MMP2
30 facial paralysis 10.3
31 light chain deposition disease 10.3 MMP9 MMP2
32 ischemic colitis 10.3 MMP9 MMP2
33 conjunctival nevus 10.3 MMP9 MMP2
34 corneal ulcer 10.3 MMP9 MMP2
35 odontogenic myxoma 10.3 MMP9 MMP2
36 nasal cavity squamous cell carcinoma 10.3 MMP9 MMP2
37 chickenpox 10.3
38 laryngeal disease 10.3 MMP9 MMP2
39 hypertensive heart disease 10.3 MMP9 MMP2
40 sialolithiasis 10.3
41 acute pancreatitis 10.3
42 pneumothorax 10.3 MMP9 MMP2
43 adenomyosis 10.3 MMP9 MMP2
44 sjogren syndrome 10.3
45 aortic aneurysm, familial abdominal, 1 10.3 MMP9 MMP2
46 branchiootic syndrome 1 10.2
47 skin melanoma 10.2 MMP9 MMP2
48 autoimmune disease 10.2
49 salivary gland disease 10.2
50 influenza 10.2

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to Parotitis

Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 ALB CD79A G6PD H6PD MMP2 MMP9
2 neoplasm MP:0002006 8.92 ALB CD79A MMP2 MMP9

Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oseltamivir Approved Phase 4 204255-11-8, 196618-13-0 65028
2
Sargramostim Approved, Investigational Phase 1, Phase 2 83869-56-1, 123774-72-1
3
Methotrexate Approved Phase 1, Phase 2 1959-05-2, 59-05-2 126941
4
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
5
leucovorin Approved Phase 1, Phase 2 58-05-9 143 6006
6
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
7
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
8
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
9
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
10
Phenytoin Approved, Vet_approved Phase 1, Phase 2 57-41-0 1775
11
Vidarabine Approved, Investigational Phase 1, Phase 2 24356-66-9 21704 32326
12
Altretamine Approved Phase 1, Phase 2 645-05-6 2123
13
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
14
Calcium Approved, Nutraceutical Phase 1, Phase 2 7440-70-2 271
15 Vaccines Phase 2
16 Immunologic Factors Phase 1, Phase 2
17 Antiviral Agents Phase 1, Phase 2
18 Anti-Infective Agents Phase 1, Phase 2
19 Hormones Phase 1, Phase 2
20 Sodium Channel Blockers Phase 1, Phase 2
21 Alkylating Agents Phase 1, Phase 2
22 Folic Acid Antagonists Phase 1, Phase 2
23 Mitogens Phase 1, Phase 2
24 Antifungal Agents Phase 1, Phase 2
25 Diuretics, Potassium Sparing Phase 1, Phase 2
26 Cytochrome P-450 Enzyme Inducers Phase 1, Phase 2
27 Anti-Bacterial Agents Phase 1, Phase 2
28 Adjuvants, Immunologic Phase 1, Phase 2
29 Vitamin B9 Phase 1, Phase 2
30 Immunosuppressive Agents Phase 1, Phase 2
31 Antitubercular Agents Phase 1, Phase 2
32 Vitamin B Complex Phase 1, Phase 2
33 Folate Phase 1, Phase 2
34 Cyclosporins Phase 1, Phase 2
35 Antibiotics, Antitubercular Phase 1, Phase 2
36 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
37 Antibodies Phase 1, Phase 2
38 Immunoglobulins Phase 1, Phase 2
39 Antimetabolites Phase 1, Phase 2
40 Dermatologic Agents Phase 1, Phase 2
41 Anticonvulsants Phase 1, Phase 2
42 Interleukin-4 Phase 1, Phase 2
43 Antineoplastic Agents, Alkylating Phase 1, Phase 2
44 Calcineurin Inhibitors Phase 1, Phase 2
45 Antimetabolites, Antineoplastic Phase 1, Phase 2
46 Antirheumatic Agents Phase 1, Phase 2
47 Interleukin-2 Phase 1, Phase 2
48 polysaccharide-K Phase 1, Phase 2
49 Calcium, Dietary Phase 1, Phase 2
50
Morphine Approved, Investigational 57-27-2 5288826

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
2 Safety and Efficacy of Attenuated Mumps Vaccine (Human Diploid Cell) Unknown status NCT03133923 Phase 2
3 A Phase I/II Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplant for the Treatment of Patients With Hematologic Malignancies Using Busulfan, Fludarabine and Total Body Irradiation Completed NCT00245037 Phase 1, Phase 2 busulfan;cyclosporine;fludarabine phosphate;mycophenolate mofetil;Granulocyte colony-stimulating factor (G-CSF);Phenytoin;Methotrexate
4 Transplantation of Expanded and Unexpanded Umbilical Cord Blood Units Following Myeloablative Chemotherapy for Hematologic Malignancies Terminated NCT00539656 Phase 1, Phase 2
5 Gender and Opioid Consumption Unknown status NCT03006627 postoperative morphine

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

Genetic Tests for Parotitis

Anatomical Context for Parotitis

MalaCards organs/tissues related to Parotitis:

41
Salivary Gland, Testes, Bone, Pancreas, Thyroid, Bone Marrow, Brain

Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 2077)
# Title Authors PMID Year
1
New insights into juvenile parotitis. 9 38
16303695 2005
2
Chronic parotitis: not another SPINKosis. 9 38
15753612 2004
3
Juvenile recurrent parotitis: Diagnostic and therapeutic effectiveness of sialography. Retrospective study on 110 children. 38
31202035 2019
4
Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps Virus. 38
31118251 2019
5
Parotitis: An Initial Manifestation of Kawasaki Disease. 38
31378519 2019
6
Bilateral parotitis following doxycycline use. 38
31409734 2019
7
Juvenile Recurrent Parotitis. 38
30788670 2019
8
Parotitis coexisting with Kawasaki disease in a child: a rare presentation of Kawasaki disease. 38
30898051 2019
9
Severe idiopathic pneumoparotitis: Case report and study review. 38
31374539 2019
10
Core curriculum illustration: pediatric viral parotitis. 38
28593330 2019
11
Correction to: Core curriculum illustration: pediatric viral parotitis. 38
31254237 2019
12
Single-photon emission computed tomography/computed tomography for evaluation of salivary gland dysfunction: preliminary study on diagnostic ability of maximum standardized uptake value. 38
31201645 2019
13
A case of Kawasaki disease presenting with parotitis: A case report and literature review. 38
31145317 2019
14
Role of Salivary Duct Morphology in the Etiology of Chronic Obstructive Parotitis: Statistical Analysis of Sialographic Features and Computational Fluid Dynamics Analysis of Salivary Flow. 38
30576669 2019
15
Parotid ductal stenosis after facial cosmetic surgery (2 case reports). 38
30985650 2019
16
Simultaneous parotitis and ipsilateral herpes zoster ophthalmicus: coincidence? 38
30898945 2019
17
Could human bocavirus be a causative agent of parotitis in children? 38
29751940 2019
18
Mumps in a highly vaccinated Marshallese community in Arkansas, USA: an outbreak report. 38
30635255 2019
19
Surgical Treatment of Chronic Parotitis. 38
30647789 2019
20
The association between Parkinson's disease and temporomandibular disorder. 38
31199837 2019
21
[Oral health in patients with systemic sclerosis]. 38
31322605 2019
22
Acute Parotitis: A Rare Complication of Fine Needle Aspiration in Warthin Tumour. 38
31293999 2019
23
Tuberculous parotitis: A series of eight cases and review of literature. 38
31205402 2019
24
Deep Parotid Lobe Abscess Presenting with Dysphagia and Trismus. 38
30918736 2019
25
Juvenile Sjögren's syndrome: clinical characteristics with focus on salivary gland ultrasonography. 38
30697959 2019
26
The correlation of immunologic derangement and juvenile recurrent parotitis: an investigation of the laboratory immunological observation. 38
30702022 2018
27
Mucormycotic parotitis and otitis causing facial nerve palsy in a diabetic patient. 38
29904969 2018
28
Prevalence and etiology of molar-incisor hypomineralization (MIH) in the city of Istanbul. 38
30895140 2018
29
Juvenile recurrent parotitis: A systematic review of treatment studies. 38
30055724 2018
30
Methicillin-Resistant Staphylococcus aureus Parotitis Leading to Mortality in an Adolescent Male. 38
29939841 2018
31
Leprosy or sarcoidosis? A diagnostic dilemma! 38
30598969 2018
32
Characteristics of Large Mumps Outbreaks in the United States during July 2010-December 2015. 38
30204850 2018
33
Non-mumps Viral Parotitis During the 2014-2015 Influenza Season in the United States. 38
29617951 2018
34
Outbreak of mumps virus genotype G infection in tribal individuals during 2016-17 in India. 38
29873412 2018
35
Influenza-Associated Parotitis During the 2014-2015 Influenza Season in the United States. 38
29617957 2018
36
Neurologic Complications of Radiation Therapy. 38
30072073 2018
37
Is Parotitis One More Complication of Influenza? The Ongoing Challenge of Determining Causal Associations. 38
29617960 2018
38
[A complex chromosome translocation with male infertility of karyotype analysis and literature review]. 38
30122779 2018
39
Diagnostic and treatment effects of sialendoscopy for patients with swelling of the parotid gland when sialoliths are undetected with computed tomography. 38
29217121 2018
40
Bruxism-induced parotitis: A retrospective case series analysis. 38
30048228 2018
41
US of Pediatric Superficial Masses of the Head and Neck. 38
29995618 2018
42
Pott Disease in a 14-year-old Girl Affected by Congenital Lamellar Ichthyosis Type 3 and Diabetes Mellitus. 38
30166818 2018
43
[Altered indication for parotidectomy in north-western Brandenburg: A longitudinal study]. 38
29635677 2018
44
Neonatal Parotitis. 38
29428272 2018
45
Acute parotitis due to MRSA causing Lemierre's syndrome. 38
29942528 2018
46
Estimation of proton density fat fraction of the salivary gland. 38
29376736 2018
47
Facial and limb angioedema with parotitis and Kikuchi-like necrotizing lymphadenitis preceding neuropsychiatric systemic lupus erythematosus in a young African American male. 38
28849689 2018
48
Sarcoidosis presenting with acute dacryoadenitis. 38
29257721 2018
49
Mycobacterium mageritense Parotitis in an Immunocompetent Adult. 38
29434394 2018
50
Sialendoscopy in treatment of adult chronic recurrent parotitis without sialolithiasis. 38
29290052 2018

Variations for Parotitis

Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for Parotitis

GO Terms for Parotitis

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ephrin receptor signaling pathway GO:0048013 9.46 MMP9 MMP2
2 glucose metabolic process GO:0006006 9.43 H6PD G6PD
3 extracellular matrix disassembly GO:0022617 9.4 MMP9 MMP2
4 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.37 MMP9 MMP2
5 embryo implantation GO:0007566 9.32 MMP9 MMP2
6 collagen catabolic process GO:0030574 9.26 MMP9 MMP2
7 endodermal cell differentiation GO:0035987 9.16 MMP9 MMP2
8 pentose-phosphate shunt GO:0006098 8.96 H6PD G6PD
9 NADP metabolic process GO:0006739 8.62 H6PD G6PD

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.96 H6PD G6PD
2 glucose-6-phosphate dehydrogenase activity GO:0004345 8.62 H6PD G6PD

Sources for Parotitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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