MCID: PRT026
MIFTS: 42

Parotitis

Categories: Endocrine diseases, Oral diseases

Aliases & Classifications for Parotitis

MalaCards integrated aliases for Parotitis:

Name: Parotitis 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10301
MeSH 43 D010309
NCIt 49 C114281
SNOMED-CT 67 14756005
ICD10 32 K11.2
UMLS 71 C0030583

Summaries for Parotitis

Disease Ontology : 12 A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary : Parotitis is related to acute pancreatitis and meningitis. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor Kazal Type 1), and among its related pathways/superpathways are Photodynamic therapy-induced NF-kB survival signaling and Primary immunodeficiency. The drugs Oseltamivir and Sargramostim have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, lung and thyroid, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 74 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 551)
# Related Disease Score Top Affiliating Genes
1 acute pancreatitis 30.5 SPINK1 CRP ALB
2 meningitis 30.5 MMP9 CRP CD40LG ALB
3 purpura 30.2 CRP CD79A CD40LG
4 orchitis 30.1 CRP CD40LG CD4
5 keratoconjunctivitis 30.1 TRIM21 MMP9 ALB
6 cervical adenitis 30.1 CRP CD40LG
7 pneumonia 30.0 MMP9 CRP CD40LG ALB
8 immunoglobulin a deficiency 1 30.0 CD79A CD40LG
9 mediastinitis 30.0 CRP ALB
10 scarlet fever 30.0 CRP CD40LG ALB
11 guillain-barre syndrome 30.0 CD79A CD40LG ALB
12 lipoid nephrosis 30.0 CD79A CD40LG ALB
13 thrombophlebitis 29.9 CRP CD40LG ALB
14 paralytic ileus 29.9 CRP ALB
15 epiglottitis 29.9 CRP CD40LG
16 appendicitis 29.8 MMP9 CRP ALB
17 immunoglobulin alpha deficiency 29.8 CD79A CD40LG CD4
18 periodontitis 29.8 MMP9 MMP2 CRP
19 pyuria 29.7 CRP CD40LG ALB
20 vasculitis 29.7 LTF CRP CD79A CD40LG
21 pericarditis 29.7 CRP CD40LG ALB
22 typhoid fever 29.7 CRP CD40LG ALB
23 facial paralysis 29.7 CRP CD40LG CD4 ALB
24 sialadenitis 29.7 TRIM21 SSB MMP2 CD4
25 lyme disease 29.6 MMP9 CRP CD40LG
26 chickenpox 29.6 CRP CD40LG CD4 ALB
27 cellulitis 29.6 CRP CD40LG CD4
28 herpes zoster 29.6 CRP CD40LG CD4
29 meningoencephalitis 29.5 CRP CD79A CD40LG CD4 ALB
30 autoimmune disease 29.5 TRIM21 MMP9 CRP CD79A CD40LG
31 otitis media 29.4 CRP CD79A CD40LG ALB
32 secondary syphilis 29.3 CD79A CD40LG CD4
33 deficiency anemia 29.3 LTF G6PD CRP ALB
34 sjogren syndrome 29.3 TRIM21 SSB LTF CD79A CD40LG
35 anemia, autoimmune hemolytic 29.3 G6PD CD40LG CD4
36 blastomycosis 29.3 CD40LG CD4
37 actinomycosis 29.2 CRP CD4 ALB
38 extrapulmonary tuberculosis 29.2 CRP CD4 ALB
39 kawasaki disease 29.1 MMP9 CRP CD40LG CD4 ALB
40 sarcoidosis 1 29.1 CRP CD40LG CD4
41 pulmonary disease, chronic obstructive 29.1 MMP9 CRP CD4 ALB
42 iridocyclitis 29.1 CRP CD40LG CD4
43 amebiasis 29.1 CD79A CD40LG CD4 ALB
44 pharyngitis 29.1 CRP CD40LG CD4
45 bronchitis 29.0 MMP9 LTF CRP CD40LG ALB
46 dysentery 28.8 CRP CD40LG CD4 ALB
47 severe cutaneous adverse reaction 28.8 CRP CD40LG CD4 ALB
48 syphilis 28.7 CRP CD79A CD40LG CD4 ALB
49 exanthem 28.7 TRIM21 CRP CD40LG CD4 ALB
50 bacterial infectious disease 28.7 LTF CRP CD40LG CD4

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to Parotitis

Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 ALB CD4 CD40LG CD79A CRP G6PD
2 hematopoietic system MP:0005397 9.96 CD4 CD40LG CD79A G6PD LTF MMP2
3 immune system MP:0005387 9.7 ALB CD4 CD40LG CD79A CRP LTF
4 mortality/aging MP:0010768 9.36 ALB CD4 CD40LG CD79A G6PD KLK4

Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oseltamivir Approved Phase 4 196618-13-0, 204255-11-8 65028
2
Sargramostim Approved, Investigational Phase 1, Phase 2 123774-72-1, 83869-56-1
3
Methotrexate Approved Phase 1, Phase 2 1959-05-2, 59-05-2 126941
4
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
5
leucovorin Approved Phase 1, Phase 2 58-05-9 6006 143
6
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
7
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
8
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
9
Phenytoin Approved, Vet_approved Phase 1, Phase 2 57-41-0 1775
10
Vidarabine Approved, Investigational Phase 1, Phase 2 24356-66-9 32326 21704
11
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
12
Altretamine Approved Phase 1, Phase 2 645-05-6 2123
13
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
14
Calcium Approved, Nutraceutical Phase 1, Phase 2 7440-70-2 271
15 Vaccines Phase 2
16 Immunologic Factors Phase 1, Phase 2
17 Antiviral Agents Phase 1, Phase 2
18 Anti-Infective Agents Phase 1, Phase 2
19 Interleukin-4 Phase 1, Phase 2
20 Alkylating Agents Phase 1, Phase 2
21 Interleukin-2 Phase 1, Phase 2
22 Antitubercular Agents Phase 1, Phase 2
23 Antibiotics, Antitubercular Phase 1, Phase 2
24 Anti-Bacterial Agents Phase 1, Phase 2
25 Vitamin B Complex Phase 1, Phase 2
26 Folic Acid Antagonists Phase 1, Phase 2
27 Dermatologic Agents Phase 1, Phase 2
28 Mitogens Phase 1, Phase 2
29 Sodium Channel Blockers Phase 1, Phase 2
30 Folate Phase 1, Phase 2
31 Vitamin B9 Phase 1, Phase 2
32 Cyclosporins Phase 1, Phase 2
33 polysaccharide-K Phase 1, Phase 2
34 Antifungal Agents Phase 1, Phase 2
35 Immunosuppressive Agents Phase 1, Phase 2
36 Antimetabolites Phase 1, Phase 2
37 Antirheumatic Agents Phase 1, Phase 2
38 Anticonvulsants Phase 1, Phase 2
39 Diuretics, Potassium Sparing Phase 1, Phase 2
40 Calcium, Dietary Phase 1, Phase 2
41 Calcineurin Inhibitors Phase 1, Phase 2
42 Adjuvants, Immunologic Phase 1, Phase 2
43 Hormones Phase 1, Phase 2
44 Immunoglobulins Phase 1, Phase 2
45 Antibodies Phase 1, Phase 2
46
Morphine Approved, Investigational 57-27-2 5288826
47 Narcotics
48 Analgesics, Opioid
49 Central Nervous System Depressants
50 Analgesics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
2 Safety and Efficacy of Attenuated Mumps Vaccine (Human Diploid Cell) Unknown status NCT03133923 Phase 2
3 A Phase I/II Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplant for the Treatment of Patients With Hematologic Malignancies Using Busulfan, Fludarabine and Total Body Irradiation Completed NCT00245037 Phase 1, Phase 2 busulfan;cyclosporine;fludarabine phosphate;mycophenolate mofetil;Granulocyte colony-stimulating factor (G-CSF);Phenytoin;Methotrexate
4 Transplantation of Expanded and Unexpanded Umbilical Cord Blood Units Following Myeloablative Chemotherapy for Hematologic Malignancies Terminated NCT00539656 Phase 1, Phase 2
5 Gender and Opioid Consumption Unknown status NCT03006627 postoperative morphine
6 Treatment of Juvenile Recurrent Parotitis: the Yield of Minimally Invasive Intervention, a Prospective Controlled Study Not yet recruiting NCT04074694

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

Genetic Tests for Parotitis

Anatomical Context for Parotitis

MalaCards organs/tissues related to Parotitis:

40
Salivary Gland, Lung, Thyroid, Bone, Heart, Bone Marrow, Testes

Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 2094)
# Title Authors PMID Year
1
New insights into juvenile parotitis. 54 61
16303695 2005
2
Chronic parotitis: not another SPINKosis. 54 61
15753612 2004
3
A 13-Year-Old Boy Who Has Kawasaki Disease Shock Syndrome Presents with Parotitis. 61
31984160 2020
4
Sjögren's syndrome in children with recurrent parotitis. 61
31731017 2020
5
Doxorubicin and cyclophosphamide-induced parotitis: A case report. 61
31539173 2020
6
Salivary Gland Disorders in Children and Adolescents: A 15-year Experience. 61
31929831 2020
7
Pediatric sialendoscopy: An 11-year study from a single tertiary care center. 61
31972384 2020
8
Juvenile Sjögren's Syndrome: Clinical Characteristics With Focus on Salivary Gland Ultrasonography. 61
30697959 2020
9
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in the oromaxillofacial head and neck region: A retrospective analysis of 105 patients. 61
31733094 2020
10
The Accessory Parotid Gland and its Clinical Significance. 61
31856138 2019
11
Anti-cancer effects of Polyphyllin I: An update in 5 years. 61
31870841 2019
12
Juvenile recurrent parotitis: Soft foods contribute to the delayed development of salivary glands. 61
31828830 2019
13
Parotitis: An Initial Manifestation of Kawasaki Disease. 61
31378519 2019
14
Influenza A-associated parotitis in a 5-year-old boy. 61
31721373 2019
15
Bilateral parotitis following doxycycline use. 61
31409734 2019
16
[Neonatal suppurative parotitis]. 61
31794049 2019
17
Evaluation of Outcomes following Radiofrequency Ablation for Treatment of Parotid Tail Warthin Tumors. 61
31471194 2019
18
Severe idiopathic pneumoparotitis: Case report and study review. 61
31374539 2019
19
Correction to: Core curriculum illustration: pediatric viral parotitis. 61
31254237 2019
20
Intra-auricular modification of facelift incision decreased the risk of Frey syndrome. 61
31867256 2019
21
Juvenile recurrent parotitis: Diagnostic and therapeutic effectiveness of sialography. Retrospective study on 110 children. 61
31202035 2019
22
Mumps outbreak and MMR IgG surveillance as a predictor for immunity in military trainees. 61
31493948 2019
23
[Parotitis and influenza: unusual association during 2017, in Santa Fe, Argentina]. 61
31859767 2019
24
Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps Virus. 61
31118251 2019
25
Juvenile Recurrent Parotitis. 61
30788670 2019
26
Parotitis coexisting with Kawasaki disease in a child: a rare presentation of Kawasaki disease. 61
30898051 2019
27
Post-mumps acute disseminated encephalomyelitis in an adolescent. 61
31463290 2019
28
Single-photon emission computed tomography/computed tomography for evaluation of salivary gland dysfunction: preliminary study on diagnostic ability of maximum standardized uptake value. 61
31201645 2019
29
Core curriculum illustration: pediatric viral parotitis. 61
28593330 2019
30
Characteristics of Large Mumps Outbreaks in the United States, July 2010-December 2015. 61
30204850 2019
31
A case of Kawasaki disease presenting with parotitis: A case report and literature review. 61
31145317 2019
32
Parotid ductal stenosis after facial cosmetic surgery (2 case reports). 61
30985650 2019
33
Role of Salivary Duct Morphology in the Etiology of Chronic Obstructive Parotitis: Statistical Analysis of Sialographic Features and Computational Fluid Dynamics Analysis of Salivary Flow. 61
30576669 2019
34
Simultaneous parotitis and ipsilateral herpes zoster ophthalmicus: coincidence? 61
30898945 2019
35
Could human bocavirus be a causative agent of parotitis in children? 61
29751940 2019
36
Mumps in a highly vaccinated Marshallese community in Arkansas, USA: an outbreak report. 61
30635255 2019
37
Deep Parotid Lobe Abscess Presenting with Dysphagia and Trismus. 61
30918736 2019
38
Surgical Treatment of Chronic Parotitis. 61
30647789 2019
39
The association between Parkinson's disease and temporomandibular disorder. 61
31199837 2019
40
[Oral health in patients with systemic sclerosis]. 61
31322605 2019
41
Juvenile Recurrent Parotitis: The Role of Sialendoscopy. 61
31662845 2019
42
Acute Parotitis: A Rare Complication of Fine Needle Aspiration in Warthin Tumour. 61
31293999 2019
43
Tuberculous parotitis: A series of eight cases and review of literature. 61
31205402 2019
44
Prevalence and etiology of molar-incisor hypomineralization (MIH) in the city of Istanbul. 61
30895140 2018
45
The correlation of immunologic derangement and juvenile recurrent parotitis: an investigation of the laboratory immunological observation. 61
30702022 2018
46
Mucormycotic parotitis and otitis causing facial nerve palsy in a diabetic patient. 61
29904969 2018
47
Methicillin-Resistant Staphylococcus aureus Parotitis Leading to Mortality in an Adolescent Male. 61
29939841 2018
48
Juvenile recurrent parotitis: A systematic review of treatment studies. 61
30055724 2018
49
Leprosy or sarcoidosis? A diagnostic dilemma! 61
30598969 2018
50
Diagnostic and treatment effects of sialendoscopy for patients with swelling of the parotid gland when sialoliths are undetected with computed tomography. 61
29217121 2018

Variations for Parotitis

Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for Parotitis

Pathways related to Parotitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 MMP9 MMP2 CD40LG
2 10.71 CD79A CD40LG CD4
3 10.3 MMP9 MMP2 CD40LG

GO Terms for Parotitis

Cellular components related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 SPINK1 MMP9 MMP2 LTF CRP CD40LG
2 extracellular region GO:0005576 9.23 SPINK1 MMP9 MMP2 LTF KLK4 CRP

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to amyloid-beta GO:1904645 9.32 MMP9 MMP2
2 pentose-phosphate shunt GO:0006098 9.26 H6PD G6PD
3 NADP metabolic process GO:0006739 9.16 H6PD G6PD
4 positive regulation of viral entry into host cell GO:0046598 8.96 TRIM21 CD4
5 extracellular matrix disassembly GO:0022617 8.8 MMP9 MMP2 KLK4

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.73 TRIM21 MMP9 G6PD CRP CD4 ALB
2 serine-type endopeptidase activity GO:0004252 9.26 MMP9 MMP2 LTF KLK4
3 oxidoreductase activity, acting on CH-OH group of donors GO:0016614 9.16 H6PD G6PD
4 glucose-6-phosphate dehydrogenase activity GO:0004345 8.62 H6PD G6PD

Sources for Parotitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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