MCID: PRX009
MIFTS: 33

Paroxysmal Hemicrania

Categories: Neuronal diseases, Rare diseases
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Aliases & Classifications for Paroxysmal Hemicrania

MalaCards integrated aliases for Paroxysmal Hemicrania:

Name: Paroxysmal Hemicrania 19 52 58 16 71

Characteristics:


Age Of Onset:

Adolescent,Adult,Childhood,Elderly 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

MESH via Orphanet 44 D051302
ICD10 via Orphanet 32 G44.0
UMLS via Orphanet 72 C1399352
Orphanet 58 ORPHA157835
UMLS 71 C1399352

Summaries for Paroxysmal Hemicrania

NINDS: 52 Paroxysmal hemicrania is a rare form of headache that usually begins in adulthood. Patients experience severe throbbing, claw-like, or boring pain usually on one side of the face; in, around, or behind the eye; and occasionally reaching to the back of the neck. This pain may be accompanied by red and tearing eyes, a drooping or swollen eyelid on the affected side of the face, and nasal congestion. Patients may also feel dull pain, soreness, or tenderness between attacks. Attacks of paroxysmal hemicrania typically occur from 5 to 40 times per day and last 2 to 30 minutes. The disorder has two forms: chronic, in which patients experience attacks on a daily basis for a year or more, and episodic, in which the headaches may remit for months or years. Certain movements of the head or neck or external pressure to the neck may trigger these headaches in some patients. The disorder is more common in women than in men.

MalaCards based summary: Paroxysmal Hemicrania is related to headache and cluster headache. The drugs Bupivacaine and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include eye, hypothalamus and brain, and related phenotypes are migraine and recurrent paroxysmal headache

GARD: 19 A rare primary headache disorder characterized by multiple attacks of unilateral pain that occur in association with ipsilateral cranial autonomic symptoms. The hallmarks of this syndrome are the relative shortness of the attacks and the complete response to indomethacin therapy.

Orphanet: 58 A rare primary headache disorder characterized by multiple attacks of unilateral pain that occur in association with ipsilateral cranial autonomic symptoms. The hallmarks of this syndrome are the relative shortness of the attacks and the complete response to indomethacin therapy.

Related Diseases for Paroxysmal Hemicrania

Diseases related to Paroxysmal Hemicrania via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 headache 10.9
2 cluster headache 10.8
3 hemicrania continua 10.7
4 sunct headache 10.5
5 spondylocostal dysostosis 5 10.5
6 trigeminal neuralgia 10.5
7 trigeminal autonomic cephalalgia 10.4
8 ptosis 10.4
9 migraine with or without aura 1 10.3
10 orbital disease 10.2
11 horner's syndrome 10.1
12 rare headache 10.1
13 spondyloarthropathy 1 10.0
14 progressive familial heart block, type ia 10.0
15 cervical rib 10.0
16 neutrophilia, hereditary 10.0
17 paragangliomas 1 10.0
18 temporal arteritis 10.0
19 thrombophilia due to thrombin defect 10.0
20 palmoplantar keratoderma and congenital alopecia 2 10.0
21 meningioma, familial 10.0
22 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.0
23 intracranial meningioma 10.0
24 progressive familial heart block 10.0
25 migraine with aura 10.0
26 gastric ulcer 10.0
27 hydrocephalus 10.0
28 hemiplegia 10.0
29 anhidrosis 10.0
30 pituitary apoplexy 10.0
31 tolosa-hunt syndrome 10.0
32 migraine without aura 10.0
33 facial neuralgia 10.0
34 poems syndrome 10.0
35 hypothalamic disease 10.0
36 constipation 10.0
37 essential thrombocythemia 10.0
38 thrombocytosis 10.0
39 gangliocytoma 10.0
40 central nervous system origin vertigo 10.0
41 syringomyelia 10.0
42 trachea carcinoma 10.0
43 spondylitis 10.0
44 herpes zoster 10.0
45 chronic fatigue syndrome 10.0
46 parotid gland cancer 10.0
47 herpes zoster oticus 10.0
48 exophthalmos 10.0
49 intracranial hypertension 10.0
50 cough headache 10.0

Graphical network of the top 20 diseases related to Paroxysmal Hemicrania:



Diseases related to Paroxysmal Hemicrania

Symptoms & Phenotypes for Paroxysmal Hemicrania

Human phenotypes related to Paroxysmal Hemicrania:

58 30 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 migraine 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002076
2 recurrent paroxysmal headache 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002331
3 ptosis 58 30 Frequent (33%) Frequent (79-30%)
HP:0000508
4 photophobia 58 30 Frequent (33%) Frequent (79-30%)
HP:0000613
5 phonophobia 58 30 Frequent (33%) Frequent (79-30%)
HP:0002183
6 rhinitis 58 30 Frequent (33%) Frequent (79-30%)
HP:0012384
7 flushing 58 30 Frequent (33%) Frequent (79-30%)
HP:0031284
8 epiphora 58 30 Frequent (33%) Frequent (79-30%)
HP:0009926
9 rhinorrhea 58 30 Frequent (33%) Frequent (79-30%)
HP:0031417
10 conjunctival hyperemia 58 30 Frequent (33%) Frequent (79-30%)
HP:0030953
11 nausea and vomiting 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002017
12 diabetes mellitus 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000819
13 hypertension 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000822
14 palpebral edema 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100540
15 miosis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000616
16 neck pain 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0030833
17 stiff neck 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0025258
18 restless legs 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0012452
19 focal sensory seizure with olfactory features 30 Occasional (7.5%) HP:0011161
20 trigeminal neuralgia 58 Excluded (0%)
21 olfactory auras 58 Occasional (29-5%)
22 cluster headache 58 Excluded (0%)

Drugs & Therapeutics for Paroxysmal Hemicrania

Drugs for Paroxysmal Hemicrania (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
2 Anesthetics, Local Phase 2
3 Anesthetics Phase 2
4 Analgesics, Non-Narcotic Phase 2
5 Analgesics Phase 2
6
Capsaicin Approved Phase 1 404-86-4 1548943
7 Dermatologic Agents Phase 1
8 Pharmaceutical Solutions Phase 1
9
Triamcinolone Approved, Vet_approved 124-94-7 31307
10
Triamcinolone hexacetonide
11
Triamcinolone diacetate
12
Triamcinolone Acetonide 6436

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective, Randomized, Double-blinded, Placebo-controlled, Cross-over Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) Towards the Ipsilateral Pterygopalatine Fossa for the Treatment of Craniofacial Pain Not yet recruiting NCT04930887 Phase 2 Exparel (Bupivacaine Liposome);Saline
2 The Pain Biomarker Study: Changes in Circulating Pain Signalling Molecules With Activation of Pain Receptors Active, not recruiting NCT03511846 Phase 1 Oral capsaicin;Topical capsaicin;Intranasal capsaicin;Low Flow Oxygen;High Flow Oxygen
3 The Will Erwin Headache Research Center Study of Cluster Headache and Trigeminal Neuralgia Recruiting NCT02910323

Search NIH Clinical Center for Paroxysmal Hemicrania

Genetic Tests for Paroxysmal Hemicrania

Anatomical Context for Paroxysmal Hemicrania

Organs/tissues related to Paroxysmal Hemicrania:

MalaCards : Eye, Hypothalamus, Brain, Pituitary, Pineal, Heart

Publications for Paroxysmal Hemicrania

Articles related to Paroxysmal Hemicrania:

(show top 50) (show all 422)
# Title Authors PMID Year
1
Paroxysmal hemicrania in children and adolescents: A systematic review. 62
35833494 2022
2
The spectrum of indomethacin-responsive headaches in children and adolescents. 62
35302385 2022
3
[Autonomic Disorders in Trigeminal Autonomic Cephalalgias: An Update]. 62
35260525 2022
4
A Combination of Indomethacin Farnesyl and Amitriptyline Is Effective for Continuous Interictal Pain with Probable Chronic Paroxysmal Hemicrania. 62
34176839 2022
5
Indomethacin has no effect on trigeminally provoked parasympathetic output. 62
34407645 2022
6
Aura in trigeminal autonomic cephalalgia is probably mediated by comorbid migraine with aura. 62
34407649 2022
7
Paroxysmal hemicrania or short-lasting unilateral neuralgiform headache attacks with trigeminal neuralgia - functional neuroimaging findings. 62
35312033 2022
8
Pediatric-onset trigeminal autonomic cephalalgias: A systematic review and meta-analysis. 62
34407646 2021
9
Management of cluster headache and other trigeminal autonomic cephalalgias in pregnancy and breastfeeding. 62
33852763 2021
10
Indomethacin-responsive headaches-A narrative review. 62
34105154 2021
11
Paroxysmal hemifacial pain: A report of two cases. 62
33848370 2021
12
Paroxysmal Hemicrania: An Update. 62
34003159 2021
13
Noninvasive Neuromodulation in Headache: An Update. 62
34003164 2021
14
Differential actions of indomethacin: clinical relevance in headache. 62
32796319 2021
15
Long-Term Outcome of Indomethacin Treatment in Pediatric Patients with Paroxysmal Hemicrania-A Case Series. 62
33546261 2021
16
[Trigeminal autonomic cephalgias: features of diagnosis and treatment]. 62
34874664 2021
17
The Promising Effect of Nerve Decompression in Trigeminal Autonomic Cephalalgias: Report of Case Series. 62
34163429 2021
18
SUNCT/SUNA in children and adolescents: Application of ICHD-3 criteria and treatment response: Case series of 13 SUNCT/SUNA pediatric cases. 62
32867532 2021
19
Cluster headache and TACs: state of the art. 62
32845489 2020
20
Carotid body tumor as a potential cause of paroxysmal hemicrania. 62
33134628 2020
21
Paroxysmal hemicrania masquerading as a stroke in an elderly gentleman: case report. 62
33028219 2020
22
Very young age of onset in trigemino-autonomic cephalalgias - case report and review of the literature. 62
32664738 2020
23
[Cluster headache and other trigeminal autonomic cephalalgias]. 62
32779921 2020
24
Cerebral Sinus Venous Thrombosis Mimicking Probable Paroxysmal Hemicrania: A Case Report. 62
32118290 2020
25
Headache Attack Similar to Paroxismal Hemicrania Seen During Flight. 62
32493562 2020
26
Trigeminal Autonomic Cephalalgias. 62
31563236 2019
27
Do paroxysmal hemicrania and hemicrania continua represent different headaches? A retrospective study. 62
31256266 2019
28
Multiple cranial nerve blocks for the transitional treatment of chronic headaches. 62
31084198 2019
29
Facial presentations of migraine, TACs, and other paroxysmal facial pain syndromes. 62
31434691 2019
30
Non-invasive vagus nerve stimulation is beneficial in chronic paroxysmal hemicrania. 62
30709897 2019
31
Are repetitive pericranial nerve blocks effective in the management of chronic paroxysmal hemicrania?: A case report. 62
31374009 2019
32
Presentation and Management of Headache in Pituitary Apoplexy. 62
31359174 2019
33
Case Report: Shortest Course of Pediatric Paroxysmal Hemicrania. 62
31264201 2019
34
The Treatment of Trigeminal Autonomic Cephalalgias: An Overview. 62
30703174 2019
35
Trait- and Frequency-Dependent Dysfunctional Habituation to Trigeminal Nociceptive Stimulation in Trigeminal Autonomic Cephalalgias. 62
29655843 2018
36
Cluster Headache and Other Trigeminal Autonomic Cephalalgias. 62
30074553 2018
37
The pathophysiology of the trigeminal autonomic cephalalgias, with clinical implications. 62
28942483 2018
38
When Treatment Establishes Diagnosis: A Case Report of Posttraumatic Chronic Paroxysmal Hemicrania. 62
29708585 2018
39
Overview of Trigeminal Autonomic Cephalalgias: Nosologic Evolution, Diagnosis, and Management. 62
29720817 2018
40
Therapeutic Approaches for the Management of Trigeminal Autonomic Cephalalgias. 62
29516437 2018
41
Paroxysmal Hemicrania. 62
29720814 2018
42
Classification of Trigeminal Autonomic Cephalalgia: What has Changed in International Classification of Headache Disorders-3 Beta? 62
29720818 2018
43
Functional Neuroimaging in Trigeminal Autonomic Cephalalgias. 62
29720819 2018
44
Hints on Diagnosing and Treating Headache. 62
29789115 2018
45
Chronic paroxysmal headache secondary to an orbital metastatic leiomyosarcoma: A case report. 62
28058942 2018
46
Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal. 62
28730562 2017
47
Indomethacin-Responsive Paroxysmal Hemicrania in an Elderly Man: An Unusual Presentation of Pituitary Apoplexy. 62
28980712 2017
48
Tics in TACs: A Step into an Avalanche? Systematic Literature Review and Conclusions. 62
28542727 2017
49
Occipital Nerve Stimulation for Medically Refractory Chronic Paroxysmal Hemicrania. 62
28980700 2017
50
The anterior hypothalamus in cluster headache. 62
27530226 2017

Variations for Paroxysmal Hemicrania

Expression for Paroxysmal Hemicrania

Search GEO for disease gene expression data for Paroxysmal Hemicrania.

Pathways for Paroxysmal Hemicrania

GO Terms for Paroxysmal Hemicrania

Sources for Paroxysmal Hemicrania

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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