MCID: PRX009
MIFTS: 33

Paroxysmal Hemicrania

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Paroxysmal Hemicrania

MalaCards integrated aliases for Paroxysmal Hemicrania:

Name: Paroxysmal Hemicrania 20 53 58 17 71

Characteristics:

Orphanet epidemiological data:

58
paroxysmal hemicrania
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

MESH via Orphanet 45 D051302
ICD10 via Orphanet 33 G44.0
UMLS via Orphanet 72 C1399352
Orphanet 58 ORPHA157835
UMLS 71 C1399352

Summaries for Paroxysmal Hemicrania

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 157835DefinitionA rare primary headache disorder characterized by multiple attacks of unilateral pain that occur in association with ipsilateral cranial autonomic symptoms. The hallmarks of this syndrome are the relative shortness of the attacks and the complete response to indomethacin therapy.EpidemiologyParoxysmal hemicrania (PH) prevalence is unknown. There is a male-to-female ratio of 1:1.Clinical descriptionThe mean age of onset is 40 years (range 3-81 years). PH patients experience purely unilateral, severe to very severe attacks of head pain. The pain is often in the temporal, orbital or supraorbital region. The pain has an abrupt start and cessation and is accompanied by ipsilateral autonomic features, including lacrimation, conjunctival injection, rhinorrhoea, nasal congestion, periorbital oedema, facial flushing, miosis and/or ptosis. PH attacks last 2-30 minutes and occur more than 5 times a day up to 40 times a day with a mean of 11 a day. Patients can have unilateral photophobia and phonophobia ipsilateral to the side of the attack. Osmophobia, nausea or vomiting during the attacks has been reported. Although attacks are most usually spontaneous, attacks can be triggered by neck movements, or pressure over the neck or greater occipital nerves. PH can be classified as episodic or chronic, depending on the duration of pain-free period when untreated. Episodic paroxysmal hemicrania patients have bouts lasting from 7 days to 1 year and separated by pain-free periods more than 3 months, whereas in chronic patients the pain-free period is less than 3 months. As this is a primary headache disorder, patients have normal neurological tests.EtiologyEtiology remains unclear.Diagnostic methodsDiagnosis is based on clinical history and response to indomethacin. Patients with suspected paroxysmal hemicrania should undergo an oral indomethacin trial or placebo-controlled intramuscular indomethacin test. In adults, one could start with 25mg three times a day, titrating up to 75mg three times a day over the course of 3 weeks. With intramuscular indomethacin 100-200 mg could be used.Differential diagnosisCluster headache is the main differential diagnosis, given the overlap in duration of the attacks. It is very important to differentiate PH from cluster headache, as treatment differs greatly.Genetic counselingRare cases of familial PH have been reported.Management and treatmentA complete response to indomethacin confirms the diagnosis of PH. Treatment with indomethacin with a median dose of 150 mg/day (ranging from 30-300mg/day) results in dramatic relief of the disabling symptoms caused by PH.PrognosisThis is a debilitating headache condition if not accurately diagnosed and managed.Visit the Orphanet disease page for more resources.

MalaCards based summary : Paroxysmal Hemicrania is related to headache and cluster headache. An important gene associated with Paroxysmal Hemicrania is CALCA (Calcitonin Related Polypeptide Alpha). The drugs Capsaicin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, hypothalamus and pituitary, and related phenotypes are migraine and recurrent paroxysmal headache

NINDS : 53 Paroxysmal hemicrania is a rare form of headache that usually begins in adulthood. Patients experience severe throbbing, claw-like, or boring pain usually on one side of the face; in, around, or behind the eye; and occasionally reaching to the back of the neck. This pain may be accompanied by red and tearing eyes, a drooping or swollen eyelid on the affected side of the face, and nasal congestion. Patients may also feel dull pain, soreness, or tenderness between attacks. Attacks of paroxysmal hemicrania typically occur from 5 to 40 times per day and last 2 to 30 minutes. The disorder has two forms: chronic, in which patients experience attacks on a daily basis for a year or more, and episodic, in which the headaches may remit for months or years. Certain movements of the head or neck or external pressure to the neck may trigger these headaches in some patients. The disorder is more common in women than in men.

Related Diseases for Paroxysmal Hemicrania

Graphical network of the top 20 diseases related to Paroxysmal Hemicrania:



Diseases related to Paroxysmal Hemicrania

Symptoms & Phenotypes for Paroxysmal Hemicrania

Human phenotypes related to Paroxysmal Hemicrania:

58 31 (showing 22, show less)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 migraine 58 31 hallmark (90%) Very frequent (99-80%) HP:0002076
2 recurrent paroxysmal headache 58 31 hallmark (90%) Very frequent (99-80%) HP:0002331
3 ptosis 58 31 frequent (33%) Frequent (79-30%) HP:0000508
4 photophobia 58 31 frequent (33%) Frequent (79-30%) HP:0000613
5 phonophobia 58 31 frequent (33%) Frequent (79-30%) HP:0002183
6 rhinitis 58 31 frequent (33%) Frequent (79-30%) HP:0012384
7 epiphora 58 31 frequent (33%) Frequent (79-30%) HP:0009926
8 rhinorrhea 58 31 frequent (33%) Frequent (79-30%) HP:0031417
9 conjunctival hyperemia 58 31 frequent (33%) Frequent (79-30%) HP:0030953
10 flushing 58 31 frequent (33%) Frequent (79-30%) HP:0031284
11 nausea and vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002017
12 diabetes mellitus 58 31 occasional (7.5%) Occasional (29-5%) HP:0000819
13 hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0000822
14 palpebral edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0100540
15 miosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000616
16 neck pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0030833
17 stiff neck 58 31 occasional (7.5%) Occasional (29-5%) HP:0025258
18 restless legs 58 31 occasional (7.5%) Occasional (29-5%) HP:0012452
19 focal sensory seizure with olfactory features 31 occasional (7.5%) HP:0011161
20 trigeminal neuralgia 58 Excluded (0%)
21 olfactory auras 58 Occasional (29-5%)
22 cluster headache 58 Excluded (0%)

Drugs & Therapeutics for Paroxysmal Hemicrania

Drugs for Paroxysmal Hemicrania (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 7, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 1 404-86-4 1548943
2 Pharmaceutical Solutions Phase 1
3 Dermatologic Agents Phase 1
4
Triamcinolone Approved, Vet_approved 124-94-7 31307
5 Triamcinolone hexacetonide
6 triamcinolone acetonide
7 Triamcinolone diacetate

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 The Pain Biomarker Study: Changes in Circulating Pain Signalling Molecules With Activation of Pain Receptors Active, not recruiting NCT03511846 Phase 1 Oral capsaicin;Topical capsaicin;Intranasal capsaicin;Low Flow Oxygen;High Flow Oxygen
2 The Will Erwin Headache Research Center Study of Cluster Headache and Trigeminal Neuralgia Recruiting NCT02910323

Search NIH Clinical Center for Paroxysmal Hemicrania

Genetic Tests for Paroxysmal Hemicrania

Anatomical Context for Paroxysmal Hemicrania

MalaCards organs/tissues related to Paroxysmal Hemicrania:

40
Eye, Hypothalamus, Pituitary, Pineal

Publications for Paroxysmal Hemicrania

Articles related to Paroxysmal Hemicrania:

(showing 404, show less)
# Title Authors PMID Year
1
Differential actions of indomethacin: clinical relevance in headache. 61
32796319 2021
2
Long-Term Outcome of Indomethacin Treatment in Pediatric Patients with Paroxysmal Hemicrania-A Case Series. 61
33546261 2021
3
SUNCT/SUNA in children and adolescents: Application of ICHD-3 criteria and treatment response: Case series of 13 SUNCT/SUNA pediatric cases. 61
32867532 2021
4
Cluster headache and TACs: state of the art. 61
32845489 2020
5
Carotid body tumor as a potential cause of paroxysmal hemicrania. 61
33134628 2020
6
Paroxysmal hemicrania masquerading as a stroke in an elderly gentleman: case report. 61
33028219 2020
7
Very young age of onset in trigemino-autonomic cephalalgias - case report and review of the literature. 61
32664738 2020
8
[Cluster headache and other trigeminal autonomic cephalalgias]. 61
32779921 2020
9
Cerebral Sinus Venous Thrombosis Mimicking Probable Paroxysmal Hemicrania: A Case Report. 61
32118290 2020
10
Headache Attack Similar to Paroxismal Hemicrania Seen During Flight. 61
32493562 2020
11
Do paroxysmal hemicrania and hemicrania continua represent different headaches? A retrospective study. 61
31256266 2019
12
Trigeminal Autonomic Cephalalgias. 61
31563236 2019
13
Multiple cranial nerve blocks for the transitional treatment of chronic headaches. 61
31084198 2019
14
Facial presentations of migraine, TACs, and other paroxysmal facial pain syndromes. 61
31434691 2019
15
Non-invasive vagus nerve stimulation is beneficial in chronic paroxysmal hemicrania. 61
30709897 2019
16
Are repetitive pericranial nerve blocks effective in the management of chronic paroxysmal hemicrania?: A case report. 61
31374009 2019
17
Presentation and Management of Headache in Pituitary Apoplexy. 61
31359174 2019
18
Case Report: Shortest Course of Pediatric Paroxysmal Hemicrania. 61
31264201 2019
19
The Treatment of Trigeminal Autonomic Cephalalgias: An Overview. 61
30703174 2019
20
Trait- and Frequency-Dependent Dysfunctional Habituation to Trigeminal Nociceptive Stimulation in Trigeminal Autonomic Cephalalgias. 61
29655843 2018
21
Cluster Headache and Other Trigeminal Autonomic Cephalalgias. 61
30074553 2018
22
The pathophysiology of the trigeminal autonomic cephalalgias, with clinical implications. 61
28942483 2018
23
When Treatment Establishes Diagnosis: A Case Report of Posttraumatic Chronic Paroxysmal Hemicrania. 61
29708585 2018
24
Paroxysmal Hemicrania. 61
29720814 2018
25
Overview of Trigeminal Autonomic Cephalalgias: Nosologic Evolution, Diagnosis, and Management. 61
29720817 2018
26
Therapeutic Approaches for the Management of Trigeminal Autonomic Cephalalgias. 61
29516437 2018
27
Functional Neuroimaging in Trigeminal Autonomic Cephalalgias. 61
29720819 2018
28
Classification of Trigeminal Autonomic Cephalalgia: What has Changed in International Classification of Headache Disorders-3 Beta? 61
29720818 2018
29
Hints on Diagnosing and Treating Headache. 61
29789115 2018
30
Chronic paroxysmal headache secondary to an orbital metastatic leiomyosarcoma: A case report. 61
28058942 2018
31
Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal. 61
28730562 2017
32
Occipital Nerve Stimulation for Medically Refractory Chronic Paroxysmal Hemicrania. 61
28980700 2017
33
Indomethacin-Responsive Paroxysmal Hemicrania in an Elderly Man: An Unusual Presentation of Pituitary Apoplexy. 61
28980712 2017
34
Tics in TACs: A Step into an Avalanche? Systematic Literature Review and Conclusions. 61
28542727 2017
35
Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing-like attacks in a pediatric patient found to have a pontine capillary telangiectasia and developmental venous anomaly: A case report exploring the root of the problem. 61
27342226 2017
36
The anterior hypothalamus in cluster headache. 61
27530226 2017
37
LASH: A Review of the Current Literature. 61
28681219 2017
38
"Cough Hemicrania" - An Overlapping Form of Headache: Case Reports. 61
28411371 2017
39
Paroxysmal Hemicrania-Like Headache Secondary to Phosphodiesterase Inhibitors Administration: A Case Report. 61
28188618 2017
40
Management of children and young people with headache. 61
27998893 2017
41
The cavernous sinus in cluster headache - a quantitative structural magnetic resonance imaging study. 61
27009562 2017
42
The Rare Painful Phenomena - Chronic Paroxysmal Hemicrania-tic Syndrome as a Clinically Isolated Syndrome of the Central Nervous System. 61
28158167 2017
43
Cracked tooth syndrome mimicking trigeminal autonomic cephalalgia: A report of four cases. 61
28168240 2017
44
Can paroxysmal hemicrania be bilateral? A case report. 61
27023075 2016
45
Alcohol-induced headaches: Evidence for a central mechanism? 61
27114660 2016
46
Trigeminal Autonomic Cephalalgias in Children and Adolescents: Cluster Headache and Related Conditions. 61
27017018 2016
47
Coexistence of contralateral cluster headache and probable paroxysmal hemicrania: a case report. 61
27047722 2016
48
Linear headache: clinical characteristics of eight new cases. 61
27057481 2016
49
Trigeminal autonomic cephalalgias. 61
24888770 2016
50
O043. Frequency-dependent habituation deficit of the nociceptive blink reflex in cluster headache and paroxysmal hemicrania. 61
28132297 2015
51
Pediatric paroxysmal hemicrania: a case report and some clinical considerations. 61
26265294 2015
52
Trigeminal Autonomic Cephalalgias. 61
26252590 2015
53
Putative pathophysiological mechanisms in recurrent hemicrania from aortic dissection: a case report. 61
26082134 2015
54
A case of post-traumatic LASH syndrome responsive to indomethacin and melatonin (a man with a unique triad of indomethacin-responsive trigeminal autonomic cephalalgias). 61
25078719 2015
55
When indomethacin fails: additional treatment options for "indomethacin responsive headaches". 61
25754595 2015
56
Diagnose and adios: practical tips for the ongoing evaluation and care of TAC patients taking indomethacin. 61
25501954 2015
57
Indomethacin-responsive headaches. 61
25467407 2015
58
The Neuropharmacology of Cluster Headache and other Trigeminal Autonomic Cephalalgias. 61
26411963 2015
59
[Trigeminal autonomic cephalgias]. 61
27030837 2015
60
[Hemicrania continua and paroxysmal hemicrania: clinical and therapeutic characteristics in a series of 23 patients]. 61
25297475 2014
61
Trigeminal autonomic headaches caused by a multinodular goiter--a case report. 61
24628230 2014
62
[Therapy of trigeminal autonomic headaches]. 61
25005009 2014
63
Paroxysmal hemicrania: an update. 61
24523000 2014
64
Evaluation and management of "sinus headache" in the otolaryngology practice. 61
24680494 2014
65
Concomitant occurrence of different trigeminal autonomic cephalalgias: a case series and review of the literature. 61
24065715 2014
66
The normal and variant clinical anatomy of the sensory supply of the orbit. 61
24430947 2014
67
The coexistence of paroxysmal hemicrania and temporomandibular disorder: importance of multidisciplinary approach. 61
24748314 2014
68
Trigeminal autonomic cephalalgias: beyond the conventional treatments. 61
24974071 2014
69
[Update on trigeminal autonomic cephalalgia]. 61
24212418 2013
70
Chronic daily headache in the elderly. 61
24173611 2013
71
Sleep-related headache and its management. 61
24132786 2013
72
Indomethacin-induced de novo headache in hemicrania continua--fighting fire with fire? 61
23709499 2013
73
The usual treatment of trigeminal autonomic cephalalgias. 61
24090529 2013
74
Indomethacin-responsive TACs (paroxysmal hemicrania, hemicrania continua, and LASH): further proof of a distinct spectrum of headache disorders. 61
23278259 2013
75
Primary headache disorders. 61
23809307 2013
76
Hemicrania continua. Unquestionably a trigeminal autonomic cephalalgia. 61
23573839 2013
77
Mechanism of action of indomethacin in indomethacin-responsive headaches. 61
23423598 2013
78
Management of trigeminal autonomic cephalalgias in children and adolescents. 61
23475698 2013
79
Trigeminal autonomic cephalalgias other than cluster headache. 61
23419629 2013
80
Paroxysmal hemicrania: a retrospective study of a consecutive series of 22 patients and a critical analysis of the diagnostic criteria. 61
23566235 2013
81
Diagnostic distribution of 100 unilateral, side-locked headaches consulting a specialized clinic. 61
23445663 2013
82
[Trigeminal autonomic cephalgias - new aspects and concepts]. 61
22915385 2012
83
Bilateral paroxysmal cephalalgia: a novel indomethacin-responsive primary headache syndrome? 61
22843224 2012
84
Trigeminal autonomic cephalalgias: A review of recent diagnostic, therapeutic and pathophysiological developments. 61
23024564 2012
85
Trigeminal autonomic cephalalgias. 61
22868548 2012
86
12 minute consultation: evidence based management of a patient with facial pain. 61
22708936 2012
87
Alcohol as a dietary trigger of primary headaches: what triggering site could be compatible? 61
22644204 2012
88
Triptans: over the migraine. 61
22644202 2012
89
From neuroimaging to patients' bench: what we have learnt from trigemino-autonomic pain syndromes. 61
22644181 2012
90
[Paroxysmal hemicrania and SUNCT]. 61
22120922 2011
91
Clinical features of unilateral headaches beyond migraine and cluster headache and their response to indomethacin. 61
21833596 2011
92
Paroxysmal hemicrania as the clinical presentation of giant cell arteritis. 61
24765352 2011
93
Further on menstrual paroxysmal hemicrania. 61
21278240 2011
94
Trigeminal autonomic cephalalgia sine headache. 61
20976466 2011
95
Chronic paroxysmal hemicrania in paediatric age: report of two cases. 61
21340658 2011
96
[A woman with unilateral headache]. 61
21494306 2011
97
Hemicrania continua changed to chronic paroxysmal hemicrania after treatment with cyclooxygenase-2 inhibitor. 61
21284612 2011
98
A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches. 61
20978816 2010
99
Are Cox-2 drugs the second line option in indomethacin responsive headaches? 61
20517705 2010
100
Patent foramen ovale in trigeminal autonomic cephalalgias and hemicrania continua: a non-specific pathophysiological occurrence? 61
20730322 2010
101
Deep brain stimulation of the posteromedial hypothalamus: indications, long-term results, and neurophysiological considerations. 61
20672915 2010
102
Cluster headache responsive to indomethacin: Case reports and a critical review of the literature. 61
20656709 2010
103
Different forms of trigeminal autonomic cephalalgias in the same patient: description of a case. 61
20376519 2010
104
Deep brain stimulation in trigeminal autonomic cephalalgias. 61
20430322 2010
105
Trigeminal autonomic cephalalgias: paroxysmal hemicrania, SUNCT/SUNA, and hemicrania continua. 61
20352588 2010
106
Episodic paroxysmal hemicrania without autonomic symptoms: are there possible subgroups in PH? 61
19515120 2010
107
Does sphenopalatine endoscopic ganglion block have an effect in paroxysmal hemicrania? A case report. 61
19438918 2010
108
[Episodic paroxysmal hemicrania with seasonal waxing and waning pattern]. 61
20209413 2010
109
Indomethacin responsive headache syndromes: chronic paroxysmal hemicrania and Hemicrania continua. How they were discovered and what we have learned since. 61
20626997 2010
110
Resolution of paroxysmal hemicrania after resection of intracranial meningioma. 61
20148710 2010
111
Incidence of facial pain in the general population. 61
19783099 2009
112
Occipital nerve blocks: when and what to inject? 61
19674126 2009
113
Successful treatment of chronic paroxysmal hemicrania with posterior hypothalamic stimulation: technical case report. 61
19834392 2009
114
Symptomatic trigeminal autonomic cephalalgias. 61
19901708 2009
115
Pathophysiology of trigeminal autonomic cephalalgias. 61
19608101 2009
116
Paroxysmal hemicrania in children--symptoms, diagnostic criteria, therapy and outcome. 61
19236385 2009
117
Neuroimaging in trigeminal autonomic cephalgias: when, how, and of what? 61
19434790 2009
118
Coexistence of cluster headache and paroxysmal hemicrania: does it exist? A case report and literature review. 61
19277837 2009
119
Trigeminal autonomic cephalalgias. 61
19289231 2009
120
Paroxysmal hemicrania with visual aura in a 17-year-old boy. 61
19348039 2009
121
Hemicrania continua: who responds to indomethacin? 61
19220311 2009
122
Chronic cluster-like headache secondary to prolactinoma: uncommon cephalalgia in association with brain tumors. 61
18694630 2009
123
A review of trigeminal autonomic cephalalgias: diagnosis and treatment. 61
19485141 2009
124
Paroxysmal hemicrania responding to topiramate. 61
21734918 2009
125
Three-year follow-up of a girl with chronic paroxysmal hemicrania. 61
19068259 2009
126
Trigeminal autonomic cephalalgias: a review and implications for dentistry. 61
19047667 2008
127
Paroxysmal hemicrania and POEMS syndrome: further evidence that neuropeptides are implicated in primary headache? 61
18644027 2008
128
An unusual form of TAC-TAC sine autonomic phenomena. 61
18685807 2008
129
Epidemiology of unilateral headaches. 61
18759543 2008
130
Headache secondary to haemorrhagic stroke resembling paroxysmal hemicrania. 61
18949281 2008
131
Cluster headache. 61
18651939 2008
132
A patient with chronic cluster headache responsive to high-dose indomethacin: is there an overlap with chronic paroxysmal hemicrania? 61
18460005 2008
133
Unilateral photophobia or phonophobia in migraine compared with trigeminal autonomic cephalalgias. 61
18422722 2008
134
Trigeminal autonomic cephalalgias: diagnostic and therapeutic developments. 61
18451717 2008
135
[Trigeminal-autonomic cephalalgias: International Headache Society diagnostic criteria does not allow for a correct classification]. 61
18516742 2008
136
Functional and structural neuroimaging in trigeminal autonomic cephalalgias. 61
18474194 2008
137
Paroxysmal hemicrania: a prospective clinical study of 31 cases. 61
18252775 2008
138
[Pathophysiology and treatment of trigeminal autonomic cephalalgias]. 61
18253766 2008
139
Bilateral paroxysmal hemicrania with autonomic symptoms: the first case report. 61
17941880 2008
140
Chronic paroxysmal hemicrania and hemicrania continua responding to topiramate: two case reports. 61
17954009 2008
141
Update on the therapy of the trigeminal autonomic cephalalgias. 61
18325297 2008
142
Neurostimulation in primary headache syndromes. 61
18052770 2007
143
Paroxysmal hemicrania-tic and Chiari I malformation: an unusual association. 61
17944959 2007
144
Trigeminal autonomic cephalalgias. Part 2: Paroxysmal hemicrania. 61
17656136 2007
145
The differential diagnosis of chronic daily headaches: an algorithm-based approach. 61
17955166 2007
146
[Trigeminal autonomic cephalgias: diagnostic and therapeutic implications]. 61
17944284 2007
147
Menstrual paroxysmal hemicrania, a possible new entity? 61
17655719 2007
148
Paroxysmal hemicrania triggered by GTN. 61
17645760 2007
149
Trigeminal autonomic cephalalgias: current and future treatments. 61
17578559 2007
150
Trigeminal autonomic cephalalgias: diagnosis and treatment. 61
17355838 2007
151
The rare, unilateral headaches. Vågå study of headache epidemiology. 61
17221345 2007
152
[Rare primary headache syndromes]. 61
17457702 2007
153
Paroxysmal hemicrania responding to topiramate. 61
17172571 2007
154
Trigeminal autonomic cephalgias due to structural lesions: a review of 31 cases. 61
17210806 2007
155
Neuromodulatory approaches to the treatment of trigeminal autonomic cephalalgias. 61
17691295 2007
156
Case series of four different headache types presenting as tooth pain. 61
17055919 2006
157
[Spontaneous pain attacks: neuralgic pain]. 61
17147031 2006
158
Coexistence of TACS and trigeminal neuralgia: pathophysiological conjectures. 61
17115989 2006
159
[Headaches in women]. 61
17219816 2006
160
EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias. 61
16987158 2006
161
Association between chronic paroxysmal hemicrania and primary trochlear headache: pathophysiology and treatment. 61
16961797 2006
162
Short-lasting headaches in children. 61
16961790 2006
163
Black, white and shades of grey: SUNCT or short-lasting chronic paroxysmal hemicrania? 61
17119794 2006
164
Hemicrania continua evolving from episodic paroxysmal hemicrania. 61
16919066 2006
165
Impact of extreme light exposure during summer season in an arctic area on patients with migraine and chronic paroxysmal hemicrania (CPH). 61
16919069 2006
166
Chronic paroxysmal hemicrania: from the index patient to the disease. 61
16834945 2006
167
Chronic paroxysmal hemicrania, hemicrania continua and SUNCT: the fate of the three first described cases. 61
16817054 2006
168
Chronic paroxysmal hemicrania in a patient with a macroprolactinoma. 61
16686914 2006
169
Paroxysmal hemicrania in a family. 61
16556252 2006
170
Paroxysmal hemicrania, SUNCT, and hemicrania continua. 61
16628536 2006
171
Chronic paroxysmal hemicrania presenting as recurrent orbital inflammation. 61
16643568 2006
172
Chronic paroxysmal hemicrania in a 3-year, 10-month-old female. 61
16504793 2006
173
Posterior hypothalamic activation in paroxysmal hemicrania. 61
16489610 2006
174
Retino-hypothalamic-pineal hypothesis in the pathophysiology of primary headaches. 61
16530980 2006
175
Paroxysmal hemicrania after carotid aneurysm embolization. 61
16232164 2005
176
Seasonal, extratrigeminal, episodic paroxysmal hemicrania successfully treated with single suboccipital steroid injections. 61
16241981 2005
177
Facial pain in a neurological tertiary care centre--evaluation of the International Classification of Headache Disorders. 61
16109050 2005
178
Osmophobia in primary headaches. 61
16362667 2005
179
Aura with non-migraine headache. 61
16004842 2005
180
[Treatment of cluster headache]. 61
16141963 2005
181
Trigeminal autonomic cephalalgias. Pathophysiology and classification. 61
16141962 2005
182
Paroxysmal hemicrania-tic syndrome responsive to acetazolamide. 61
15955044 2005
183
[Treatment and prophylaxis for cluster headaches and other trigeminal autonomic headaches. Revised recommendations of the German Migraine and Headache Society]. 61
15887001 2005
184
[Trigeminal autonomic headache, hemicrania continua and hypnic headache. A review of rare primary headache forms]. 61
15875267 2005
185
Differentiating paroxysmal hemicrania from cluster headache. 61
15773820 2005
186
Cluster headache and paroxysmal hemicrania: differential diagnosis. 61
15773821 2005
187
Cognitive processing in cluster headache. 61
15745620 2005
188
An unusual indomethacin-sensitive headache: a case of bilateral episodic paroxysmal hemicrania without autonomic symptoms? 61
15658952 2005
189
Bilateral paroxysmal hemicrania or bilateral paroxysmal cephalalgia, another novel indomethacin-responsive primary headache syndrome? 61
15658943 2005
190
Calcitonin gene-related peptide antagonists as treatments of migraine and other primary headaches. 61
16392873 2005
191
Lower-half facial migraine: a report of 11 cases. 61
15573344 2004
192
[Headache originating front-orbital area]. 61
15651301 2004
193
Trigeminal autonomic cephalalgias: from pathophysiology to clinical aspects. 61
15549574 2004
194
Strategies for the treatment of autonomic trigeminal cephalalgias. 61
15549530 2004
195
[Trigeminal autonomic cephalgias: diagnosis, therapy, atypical forms and pathophysiology]. 61
15536569 2004
196
[Headache attacks with ipsilateral autonomic symptoms]. 61
15449166 2004
197
Case report: diagnosis and management of trigeminal neuralgia and chronic paroxysmal hemicrania in a 43-year-old woman- oral and transmucosal pharamcologic mediations. 61
23924764 2004
198
Hypothalamic activation in trigeminal autonomic cephalgia: functional imaging of an atypical case. 61
15315531 2004
199
Short-lasting headache syndromes and treatment options. 61
15228884 2004
200
Chronic paroxysmal hemicrania in early childhood: case report. 61
15196305 2004
201
Rare nocturnal headaches. 61
15167064 2004
202
Seasonal episodic paroxysmal hemicrania responding to cyclooxygenase-2 inhibitors. 61
15096232 2004
203
[Paroxysmal hemicrania]. 61
15307312 2004
204
Chronic paroxysmal hemicrania as a manifestation of intracranial parotid gland carcinoma metastasis--a case report. 61
15009016 2004
205
Chronic paroxysmal hemicrania, hemicrania continua and SUNCT syndrome in association with other pathologies: a review. 61
15009010 2004
206
[Therapeutic concepts in the treatment of headache]. 61
15219127 2004
207
Botulinum toxin in the treatment of rare head and neck pain syndromes: a systematic review of the literature. 61
14991339 2004
208
Cluster headache and the sympathetic nerve. 61
14756860 2004
209
Cervicogenic headache: practical approaches to therapy. 61
15377169 2004
210
Non-lateralized pain in a case of chronic paroxysmal hemicrania? 61
14687013 2004
211
Facial pain and sinonasal surgery. 61
14750345 2003
212
Headaches with (ipsilateral) autonomic symptoms. 61
14648142 2003
213
[Trigemino-autonomic cephalalgias. Report of two cases]. 61
15174256 2003
214
A patient with cluster headache responsive to indomethacin: any relationship with chronic paroxysmal hemicrania? 61
12780773 2003
215
[Determining the diagnosis from the pain pattern. Brief and stabbing or chronic and dull?]. 61
12813974 2003
216
International Headache Society classification: new proposals about chronic headache. 61
12811600 2003
217
Hemicrania continua: clinical and nosographic update. 61
12811608 2003
218
Rofecoxib for the treatment of chronic paroxysmal hemicrania. 61
12716352 2003
219
Parenteral indomethacin (the INDOTEST) in cluster headache. 61
12662186 2003
220
Clinical, anatomical, and physiologic relationship between sleep and headache. 61
12603650 2003
221
The paroxysmal hemicrania-tic syndrome. 61
12534576 2003
222
Management of trigeminal autonomic cephalgias and hemicrania continua. 61
12904085 2003
223
Chronic paroxysmal hemicrania: a case report and review of the literature. 61
12756934 2003
224
Facial migraine in a rhinological setting. 61
12472524 2002
225
Paroxysmal hemicrania and cluster headache: two discrete entities or is there an overlap? 61
12472514 2002
226
Treatment of headache with botulinum toxin A--a review according to evidence-based medicine criteria. 61
12421155 2002
227
Refining the clinical spectrum of chronic paroxysmal hemicrania: a review of 74 patients. 61
12390632 2002
228
Pathophysiology of cluster headache: a trigeminal autonomic cephalgia. 61
12849458 2002
229
SUNCT Syndrome: diagnosis and treatment. 61
12027784 2002
230
Episodic paroxysmal hemicrania with seasonal variation: case report and the EPH-cluster headache continuum hypothesis. 61
11733843 2001
231
The hemicrania continua diagnosis. 61
11843864 2001
232
Dose, efficacy and tolerability of long-term indomethacin treatment of chronic paroxysmal hemicrania and hemicrania continua. 61
11903285 2001
233
Hemicrania continua: diagnostic criteria and nosologic status. 61
11903280 2001
234
Sleep and pain. 61
12531004 2001
235
[Both neurogenic and vascular causes of primary headache]. 61
11680150 2001
236
Paroxysmal hemicrania-tic syndrome. 61
11437905 2001
237
Effective management of ice pick pains, SUNCT, and episodic and chronic paroxysmal hemicrania. 61
11309219 2001
238
[Sleep-related headaches]. 61
11383387 2001
239
Trigeminal autonomic cephalgias (TACs). 61
11379270 2001
240
Indomethacin-responsive headaches in children and adolescents. 61
11332865 2001
241
Primary vascular-type craniofacial pain. 61
11911064 2001
242
Post-traumatic chronic paroxysmal hemicrania (CPH) with aura. 61
11160973 2001
243
Remitting chronic paroxysmal hemicrania or episodic paroxysmal hemicrania? 61
11135035 2000
244
Chronic paroxysmal hemicrania-like headaches in a child: response to a headache diary. 61
11135033 2000
245
Case reports: chronic paroxysmal hemicrania-tic syndrome. 61
10971666 2000
246
Cervicogenic headache: mechanisms, evaluation, and treatment strategies. 61
11070659 2000
247
Responsiveness to celecoxib in chronic paroxysmal hemicrania. 61
10908918 2000
248
[Neurologic diagnosis and therapy of headaches]. 61
10981295 2000
249
Chronic paroxysmal hemicrania-tic syndrome. 61
10751271 2000
250
[A specific form of headache with neuralgia-like manifestations (SUNCT-syndrome)]. 61
11195532 2000
251
Simultaneous occurrence of ipsilateral cluster headache and chronic paroxysmal hemicrania: a case report. 61
10759906 2000
252
[Idiopathic facial pain other than vascular pain]. 61
11139750 2000
253
[Carotidynia as a form of presentation of paraxysmal hemicrania]. 61
10637872 1999
254
Chronic daily bilateral headache responsive to indomethacin. 61
11279952 1999
255
Coexistence of cervicogenic headache and migraine without aura (?). 61
10713894 1999
256
Cervical cord and dorsal medullary infarction presenting with retro-orbital pain. 61
10449134 1999
257
Cognitive processing is involved in cluster headache but not in chronic paroxysmal hemicrania. 61
10430426 1999
258
Short-lasting primary headaches: focus on trigeminal automatic cephalgias and indomethacin-sensitive headaches. 61
10576887 1999
259
Coexistence of chronic paroxysmal hemicrania and benign cough headache. 61
11279922 1999
260
Chronic paroxysmal hemicrania and SUNCT syndrome. 61
10662940 1999
261
[Chronic paroxysmal hemicrania]. 61
10335126 1999
262
Extratrigeminal episodic paroxysmal hemicrania. Further clinical evidence of functionally relevant brain stem connections. 61
11279907 1998
263
Chronic paroxysmal hemicrania presenting as otalgia with a sensation of external acoustic meatus obstruction: two cases and a pathophysiologic hypothesis. 61
11279905 1998
264
A case of chronic paroxysmal hemicrania responding to subcutaneous sumatriptan. 61
9728969 1998
265
Efficacy of sumatriptan in chronic paroxysmal hemicrania. 61
11398311 1998
266
Paroxysmal hemicrania. 61
9720085 1998
267
Chronic paroxysmal hemicrania-tic syndrome. 61
9595211 1998
268
Chronic paroxysmal hemicrania and hemicrania continua: lack of efficacy of sumatriptan. 61
9563210 1998
269
Paroxysmal hemicrania. Case studies and review of the literature. 61
9540085 1998
270
Chronic paroxysmal hemicrania and hemicrania continua. Parenteral indomethacin: the 'indotest'. 61
9529768 1998
271
[Chronic paroxysmal hemicrania]. 61
9498856 1997
272
A CPH-like picture in two patients with an orbitocavernous sinus syndrome. 61
9251879 1997
273
Short-lived head pains. 61
9058402 1997
274
Chronic paroxysmal hemicrania and hemicrania continua: anaesthetic blockades of pericranial nerves. 61
9127119 1997
275
A review of paroxysmal hemicranias, SUNCT syndrome and other short-lasting headaches with autonomic feature, including new cases. 61
9055807 1997
276
Cognitive processing in primary headache: a study on event-related potentials. 61
9008504 1997
277
Neuropeptide changes in a case of chronic paroxysmal hemicrania--evidence for trigemino-parasympathetic activation. 61
8902256 1996
278
Two more secondary headaches mimicking chronic paroxysmal hemicrania. Is this the exception or the rule? 61
8824008 1996
279
Alternatives in drug treatment of chronic paroxysmal hemicrania. 61
8783475 1996
280
The relationship between headaches and sleep disturbances. 61
8550359 1995
281
[Decompressive neurovascular nose and skull-base surgery in primary headache with a rhinogenic trigger]. 61
8751191 1995
282
A piroxicam derivative partly effective in chronic paroxysmal hemicrania and hemicrania continua. 61
8530280 1995
283
CPH and hemicrania continua: requirements of high indomethacin dosages--an ominous sign? 61
7635724 1995
284
Treatment of cluster headache and its variants. 61
7551127 1995
285
Chronic paroxysmal hemicrania in a child? 61
7775183 1995
286
Chronic paroxysmal hemicrania: dissociation of the pain and autonomic features. 61
7737862 1995
287
[Chronic paroxysmal hemicrania]. 61
8556663 1995
288
Benign indomethacin-responsive headaches presenting in the orofacial region: eight case reports. 61
8995927 1995
289
Pupillary abnormalities due to sympathetic dysfunction in different forms of idiopathic headache. 61
7711469 1994
290
Acetazolamide for the treatment of chronic paroxysmal hemicrania. 61
7843957 1994
291
Paroxysmal hemicrania. 61
7832904 1994
292
Chronic paroxysmal hemicrania in a child. 61
8002324 1994
293
Personality characteristics before and after treatment of different head pain syndromes. 61
7828197 1994
294
Neurophysiological studies in chronic paroxysmal hemicrania and hemicrania continua. 61
7960734 1994
295
Assessment of International Headache Society diagnostic criteria: a reliability study. 61
7954757 1994
296
Adolescent chronic paroxysmal hemicrania responsive to verapamil monotherapy. 61
8014035 1994
297
Chronic paroxysmal hemicrania and hemicrania continua: orbital phlebography and MRI studies. 61
8132437 1994
298
Chronic paroxysmal hemicrania (CPH) and hemicrania continua: transition from one stage to another. 61
8294193 1993
299
Trigeminal neuralgia with chronic paroxysmal hemicrania: the CPH-tic syndrome. 61
8242731 1993
300
Transcranial Doppler sonography in chronic paroxysmal hemicrania. 61
7903292 1993
301
Chronic paroxysmal hemicrania in a young child: possible relation to ipsilateral occipital infarction. 61
8409264 1993
302
Paroxysmal hemicrania. 61
8327159 1993
303
Intracranial hypertension and sumatriptan efficacy in a case of chronic paroxysmal hemicrania which became bilateral. (The mechanism of indomethacin in CPH). 61
8394301 1993
304
SUNCT syndrome: forehead sweating pattern. 61
8495451 1993
305
Episodic paroxysmal hemicrania: 3 new cases and a review of the literature. 61
8496058 1993
306
Subcutaneous sumatriptan does not abort attacks of chronic paroxysmal hemicrania (CPH). 61
8388371 1993
307
Chronic paroxysmal hemicrania presenting as toothache. 61
9116630 1993
308
Low concentrations of lithium and cyclooxygenase inhibitors enhance endothelin-1 (ET-1)-induced contractions in human temporal artery, but not in porcine ophthalmic artery. 61
1468903 1992
309
Ipsilateral cluster headache and chronic paroxysmal hemicrania: two case reports. 61
1423564 1992
310
Chronic paroxysmal hemicrania which appears to arise from either third ventricle pathology or internal carotid artery pathology. 61
1423568 1992
311
Hemicrania continua and chronic paroxysmal hemicrania: a comparison of pupillometric findings. 61
1292959 1992
312
Episodic paroxysmal hemicrania: two new cases and a literature review. 61
1579250 1992
313
Hemicrania continua: attacks may alternate sides. 61
1628961 1992
314
Symptomatic chronic paroxysmal hemicrania. 61
1290485 1992
315
MMPI profiles in patients with headache or craniofacial pain: a comparative study. 61
1576650 1992
316
Symptomatic and prophylactic treatment of migraine and tension-type headache. 61
1557187 1992
317
Episodic and chronic paroxysmal hemicrania. 61
1576420 1992
318
Chronic paroxysmal hemicrania coexisting with migraine. Differential response to pharmacological treatment. 61
1551791 1992
319
["Chronic paroxysmal hemicrania" following ophthalmic herpes zoster]. 61
1529145 1992
320
Chronic paroxysmal headache: two cases with cerebrovascular disease. 61
1551790 1992
321
Organic headaches mimicking chronic paroxysmal hemicrania. 61
1551789 1992
322
Episodic paroxysmal hemicrania responsive to calcium channel blockers. 61
1538227 1992
323
Cluster headache. Our current concepts. 61
1805550 1991
324
[Neuralgiform paroxysmal migraine]. 61
1790007 1991
325
The sweating pattern in "hemicrania continua". A comparison with chronic paroxysmal hemicrania. 61
1810837 1991
326
Episodic paroxysmal hemicrania. 61
1895142 1991
327
[Episodic ++paroxysmal hemicrania or chronic paroxysmal hemicrania in pre-chronic state?]. 61
1931102 1991
328
[Cluster headache and chronic paroxysmal hemicrania: current therapy]. 61
1876217 1991
329
"Hemicrania continua": a clinical review. 61
2016164 1991
330
Treatment of the elderly patient with headache or trigeminal neuralgia. 61
1794004 1991
331
Single photon emission computed tomography (SPECT) with 99mTc-HMPAO (hexamethyl propylenamino oxime) in chronic paroxysmal hemicrania--a case report. 61
2289232 1990
332
Current issues in NSAID therapy. 61
2236338 1990
333
Thermographic findings in cranio-facial pain. 61
2228600 1990
334
"Hemicrania episodica"--a new type of headache or a pre-chronic stage of hemicrania continua? 61
2370134 1990
335
Episodic paroxysmal hemicrania: a further case and review of the literature. 61
2187950 1990
336
Diagnostics of cervicogenic headache. 61
2227537 1990
337
[What is your diagnosis? Chronic paroxysmal hemicrania]. 61
2315585 1990
338
Chronic paroxysmal hemicrania: a chronobiological study (case report). 61
2532964 1989
339
Chronic paroxysmal hemicrania (CPH): a review of the clinical manifestations. 61
2693408 1989
340
Ocular blood flow changes in cluster headache and chronic paroxysmal hemicrania. 61
2759845 1989
341
Chronic paroxysmal hemicrania. 61
2726045 1989
342
Successful aspirin prophylaxis in a child with chronic paroxysmal hemicrania. 61
2745065 1989
343
Variants of chronic paroxysmal hemicrania. 61
2706679 1989
344
Chronic paroxysmal hemicrania (CPH): nomenclature as far as the various stages are concerned. 61
2706670 1989
345
[Paroxysmal hemicrania preceding Pancoast's syndrome]. 61
2727538 1989
346
The chronic paroxysmal hemicrania concept expanded. 61
3248936 1988
347
Arachidonic acid metabolism in polymorphonuclear cells in headaches. A methodologic study. 61
3143481 1988
348
Chronic paroxysmal hemicrania. XIII. The pupillometric pattern. 61
3197102 1988
349
Cluster headache in black patients. A report of 7 cases. 61
3131888 1988
350
Chronic paroxysmal hemicrania, episodic cluster headache and classic migraine in one patient. 61
3437308 1987
351
Cluster headache and chronic paroxysmal hemicrania: how to classify borderline cases? 61
3437307 1987
352
"Hemicrania continua": a third Norwegian case. 61
3652200 1987
353
Chronic paroxysmal hemicrania: orbital phlebography and steroid treatment. A case report. 61
3652201 1987
354
Chronic paroxysmal hemicrania in a South African black. A case report. 61
3652202 1987
355
Chronic paroxysmal hemicrania: recent developments. 61
3308115 1987
356
Chronic paroxysmal hemicrania: a case report. Long-lasting remission in the chronic stage. 61
3652204 1987
357
Episodic paroxysmal hemicrania? 61
3652203 1987
358
[Chronic paroxysmal hemicrania]. 61
3581248 1987
359
Vasogenic facial pain (cluster headache). 61
3104492 1987
360
Chronic paroxysmal hemicrania. X. On the autonomic involvement. 61
2943405 1986
361
[Paroxysmal hemicrania with homolateral mydriasis]. 61
2940579 1986
362
[Cluster headache and chronic paroxysmal hemicrania--effectiveness of oxygen inhalation]. 61
3724924 1986
363
Onset of nocturnal attacks of chronic cluster headache in relation to sleep stages. 61
3727916 1986
364
Chronic paroxysmal hemicrania: the first possible bilateral case. 61
3698094 1986
365
Thermographic and pupillary asymmetry in chronic paroxysmal hemicrania. A case study. 61
4042152 1985
366
[Chronic paroxysmal hemicrania as a postpartum headache syndrome]. 61
4029589 1985
367
[Chronic paroxysmal hemicrania. Description of 5 clinical cases and nosographic considerations]. 61
2938384 1985
368
"Hemicrania continua". An indomethacin responsive headache. II. Autonomic function studies. 61
6518505 1984
369
[Is chronic paroxysmal hemicrania due to a chronic inflammatory syndrome?]. 61
6239225 1984
370
Chronic paroxysmal hemicrania: lack of pre-chronic stage. 61
6498933 1984
371
[Chronic paroxysmal hemicrania. A review based on personal cases]. 61
6483062 1984
372
[Newly described form of idiopathic headache--so-called chronic paroxysmal hemicrania (Sjaastad syndrome)]. 61
6514120 1984
373
Chronic paroxysmal hemicrania. 61
6511739 1984
374
Chronic paroxysmal hemicrania. VII. Mechanical precipitation of attacks: new cases and localization of trigger points. 61
6733779 1984
375
Chronic paroxysmal hemicrania: heart rate changes and ECG rhythm disturbances. A computerized analysis of 24 h ambulatory ECG recordings. 61
6733781 1984
376
"Hemicrania continua": another headache absolutely responsive to indomethacin. 61
6713526 1984
377
[Chronic paroxysmal hemicrania. Treatment with indomethacin and diclofenac]. 61
6729768 1984
378
Chronic paroxysmal hemicrania: salivation, tearing and nasal secretion. 61
6713521 1984
379
Chronic paroxysmal hemicrania: severity, duration and time of occurrence of attacks. 61
6538816 1984
380
[Chronic paroxysmal hemicrania]. 61
6231554 1984
381
[Chronic paroxysmal hemicrania sensitive to indomethacin]. 61
6228861 1983
382
Chronic paroxysmal hemicrania. IX. On the mechanism of attack-related sweating. 61
6627383 1983
383
Chronic paroxysmal hemicrania. VIII. The sweating pattern. 61
6850821 1983
384
Chronic paroxysmal hemicrania: first reported British case. 61
6401553 1983
385
[Paroxysmal hemicrania. Post-stenotic dilatation of the subclavian artery]. 61
6612150 1983
386
Chronic paroxysmal hemicrania. VI. Precipitation of attacks. Further studies on the precipitation mechanism. 61
7159922 1982
387
Chronic paroxysmal hemicrania: continued remission of symptoms after discontinuation of indomethacin. 61
7151150 1982
388
A case of pre-chronic paroxysmal hemicrania. 61
7116441 1982
389
Chronic paroxysmal hemicrania. 61
7070337 1982
390
A new case of "chronic paroxysmal hemicrania. 61
7333834 1981
391
Chronic paroxysmal hemicrania. A new type of treatable headache. 61
7246576 1981
392
Chronic paroxysmal hemicrania--case report of the second known definite occurrence in a male. 61
7346175 1981
393
[Chronic paroxysmal hemicrania (author's transl)]. 61
7268232 1981
394
Headache rounds. Chronic paroxysmal hemicrania: two new patients. 61
7372474 1980
395
Chronic paroxysmal hemicrania (CPH). The clinical manifestations. A review. 61
6935856 1980
396
[Chronic paroxysmal hemicrania]. 61
425198 1979
397
Chronic paroxysmal hemicrania and cluster. 61
727748 1978
398
Chronic paroxysmal hemicrania IV: "REM sleep locked" nocturnal headache attacks. 61
227025 1978
399
Chronic paroxysmal hemicrania: a case report. 61
649387 1978
400
Chronic paroxysmal hemicrania: a disabling headache syndrome responding to indomethacin. 61
655667 1978
401
Histamine metabolism in cluster headache and migraine. Catabolism of 14C histamine. 61
72800 1977
402
Cluster headache syndrome and migrain. Ophthalmological support for a two-entity theory. 61
576545 1977
403
So-called "vascular headache of the migraine type": one or more nosological entities? 61
952202 1976
404
A new (?) Clinical headache entity "chronic paroxysmal hemicrania" 2. 61
782140 1976

Variations for Paroxysmal Hemicrania

Expression for Paroxysmal Hemicrania

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Pathways for Paroxysmal Hemicrania

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Sources for Paroxysmal Hemicrania

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