IVF
MCID: PRX010
MIFTS: 25

Paroxysmal Ventricular Fibrillation (IVF)

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Paroxysmal Ventricular Fibrillation

MalaCards integrated aliases for Paroxysmal Ventricular Fibrillation:

Name: Paroxysmal Ventricular Fibrillation 20
Paroxysmal Familial Ventricular Fibrillation 20 29 6 70
Ventricular Fibrillation, Idiopathic 20 54
Ventricular Fibrillation, Paroxysmal Familial 20
Idiopathic Ventricular Fibrillation 20
Ivf 20

Classifications:



External Ids:

UMLS 70 C0340493

Summaries for Paroxysmal Ventricular Fibrillation

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 228140 Definition A rare, genetic, cardiac rhythm disease characterized by ventricular fibrillation in the absence of any structural or functional heart disease, or known repolarization abnormalities. The presence of J waves is associated with a higher risk of nocturnal ventricular fibrillation events and a higher risk of recurrence.

MalaCards based summary : Paroxysmal Ventricular Fibrillation, also known as paroxysmal familial ventricular fibrillation, is related to brugada syndrome and idiopathic ventricular fibrillation, non brugada type. An important gene associated with Paroxysmal Ventricular Fibrillation is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5).

Related Diseases for Paroxysmal Ventricular Fibrillation

Diseases in the Paroxysmal Ventricular Fibrillation family:

Ventricular Fibrillation, Paroxysmal Familial, 1 Ventricular Fibrillation, Paroxysmal Familial, 2

Diseases related to Paroxysmal Ventricular Fibrillation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 353)
# Related Disease Score Top Affiliating Genes
1 brugada syndrome 31.5 SCN5A DPP6
2 idiopathic ventricular fibrillation, non brugada type 31.4 SCN5A DPP6
3 cardiac arrhythmia 29.3 SCN5A DPP6
4 ventricular fibrillation, paroxysmal familial, 1 11.6
5 ventricular fibrillation, paroxysmal familial, 2 11.6
6 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 11.3
7 ventricular tachycardia, catecholaminergic polymorphic, 2 11.3
8 ventricular tachycardia, catecholaminergic polymorphic, 4 11.3
9 cardiac arrhythmia, ankyrin-b-related 11.2
10 polycystic ovary syndrome 11.2
11 premature menopause 11.1
12 infertility 11.0
13 cerebral palsy 11.0
14 ovarian hyperstimulation syndrome 10.9
15 endometriosis 10.8
16 cardiac arrest 10.7
17 cardiac conduction defect 10.7
18 ectopic pregnancy 10.6
19 male infertility 10.6
20 progressive familial heart block, type ia 10.5
21 pre-eclampsia 10.5
22 placenta disease 10.5
23 progressive familial heart block, type ib 10.5
24 right bundle branch block 10.5
25 gestational diabetes 10.4
26 body mass index quantitative trait locus 1 10.4
27 azoospermia 10.4
28 thrombophilia 10.4
29 chromosomal triplication 10.3
30 early repolarization associated with ventricular fibrillation 10.3
31 catecholaminergic polymorphic ventricular tachycardia 10.3
32 ovarian cyst 10.3
33 down syndrome 10.3
34 adenomyosis 10.3
35 eclampsia 10.3
36 arts syndrome 10.3
37 brugada syndrome 1 10.3
38 long qt syndrome 10.3
39 anovulation 10.3
40 hair whorl 10.3
41 placenta praevia 10.3
42 anxiety 10.2
43 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
44 syncope 10.2
45 chlamydia 10.2
46 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
47 ovarian disease 10.2
48 leiomyoma 10.2
49 hypogonadism 10.2
50 48,xyyy 10.2

Graphical network of the top 20 diseases related to Paroxysmal Ventricular Fibrillation:



Diseases related to Paroxysmal Ventricular Fibrillation

Symptoms & Phenotypes for Paroxysmal Ventricular Fibrillation

Drugs & Therapeutics for Paroxysmal Ventricular Fibrillation

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Noninvasive Electrocardiographic Imaging for Individuals at Risk for Apparently Idiopathic Ventricular Fibrillation. Enrolling by invitation NCT03963271

Search NIH Clinical Center for Paroxysmal Ventricular Fibrillation

Genetic Tests for Paroxysmal Ventricular Fibrillation

Genetic tests related to Paroxysmal Ventricular Fibrillation:

# Genetic test Affiliating Genes
1 Paroxysmal Familial Ventricular Fibrillation 29

Anatomical Context for Paroxysmal Ventricular Fibrillation

Publications for Paroxysmal Ventricular Fibrillation

Articles related to Paroxysmal Ventricular Fibrillation:

(show all 44)
# Title Authors PMID Year
1
Brugada syndrome and syncope: a practical approach for diagnosis and treatment. 61
33367713 2020
2
[Case of cardiac arrest due to coronary spasm during laparoscopic distal gastrectomy]. 61
21348253 2011
3
Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation. 54
20042427 2010
4
Brugada syndrome unmasked by accidental inhalation of gasoline vapors. 54
17897138 2007
5
Electrocardiogram interpretation and class I blocker challenge in Brugada syndrome. 54
16934827 2006
6
High-efficiency multiplex capillary electrophoresis single strand conformation polymorphism (multi-CE-SSCP) mutation screening of SCN5A: a rapid genetic approach to cardiac arrhythmia. 54
16712702 2006
7
Monomorphic ventricular tachycardia due to Brugada syndrome successfully treated by hydroquinidine therapy in a 3-year-old child. 54
16426410 2006
8
Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia. 54
15123648 2004
9
Single nucleotide polymorphisms of the SCN5A gene in Han Chinese and their relation with Brugada syndrome. 54
15161528 2004
10
[Single nucleotide polymorphism in SCN5A and the distribution in Chinese Han ethnic group]. 54
14985827 2004
11
Genetic analysis of the cardiac sodium channel gene SCN5A in Koreans with Brugada syndrome. 54
15338453 2004
12
Mutational screening of SCN5A linked disorders in Polish patients and their family members. 54
15306732 2004
13
Inherited arrhythmic disorders in Japan. 54
12741719 2003
14
Novel brugada SCN5A mutation leading to ST segment elevation in the inferior or the right precordial leads. 54
12693506 2003
15
A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome. 54
10940383 2000
16
Cardiac Na(+) channel dysfunction in Brugada syndrome is aggravated by beta(1)-subunit. 54
10618304 2000
17
The LQT syndromes--current status of molecular mechanisms. 54
10408028 1999
18
[Recurrent ventricular fibrillation in a patient with Prinzmetal angina pectoris--case report]. 61
10375956 1999
19
Isolated aneurysm of the left sinus of Valsalva. Rupture into the left atrium, left ventricle and dynamic coronary constriction. 61
2341483 1990
20
[Treatment of paroxysmal supraventricular tachycardia and tachyarrhythmia with verapamil]. 61
6730453 1984
21
Paroxysmal ventricular fibrillation--a case report. 61
7118139 1982
22
[Anti-arrhythmic effect of dazolicin. Clinical-pharmacological research]. 61
7194081 1980
23
Paroxysmal ventricular fibrillation in children. Long-term follow-up of three cases treated with beta-blocking agents. 61
920265 1977
24
Quinidine syncope. Paroxysmal ventricular fibrillation treated with lidocaine. 61
1059946 1975
25
[A case of Morgagni-Adams-Stokes syndrome caused by paroxysmal ventricular fibrillation. Etiopathogenetic considerations]. 61
1143668 1975
26
Familial Q-T prolongation syndrome. Convulsive seizures and paroxysmal ventricular fibrillation. 61
4834545 1974
27
Paroxysmal familial ventricular fibrillation. 61
4834245 1974
28
[Clinical and electrophysiological observations in syndrome of increased QT-time with paroxysmal ventricular fibrillation (Jervell and Lange-Nielsen syndrome)]. 61
4790109 1973
29
[Idiopathic paroxysmal ventricular fibrillation]. 61
4770413 1973
30
[General anesthesia for a patient with past history of paroxysmal ventricular fibrillation]. 61
5105404 1971
31
[Apropos of a case of Morgagni-Adams-Stokes syndrome caused by paroxysmal ventricular fibrillation in the course of complete A-V block, controlled by the use of an artificial pacemaker]. 61
5770943 1969
32
[Quinidine-induced paroxysmal ventricular fibrillation]. 61
6023836 1967
33
[Late paroxysmal ventricular fibrillation after cardioversion]. 61
4172578 1966
34
Quinidine-induced paroxysmal ventricular fibrillation treated with propranolol. 61
5941503 1966
35
Effect of propranolol on paroxysmal ventricular fibrillation. 61
5956507 1966
36
PAROXYSMAL VENTRICULAR FIBRILLATION WITH SPONTANEOUS REVERSION TO SINUS RHYTHM. 61
14242165 1965
37
PAROXYSMAL VENTRICULAR FIBRILLATION. 61
14180668 1964
38
QUINIDINE SYNCOPE. PAROXYSMAL VENTRICULAR FIBRILLATION OCCURRING DURING TREATMENT OF CHRONIC ATRIAL ARRHYTHMIAS. 61
14197832 1964
39
[A CASE OF MORGAGNI-ADAMS-STOKES SYNDROME CAUSED BY RECURRENT PAROXYSMAL VENTRICULAR FIBRILLATION]. 61
14146092 1964
40
[RARE CARDIAC ARRYTHMIAS OF THE PEDIATRIC AGE. II. SYNCOPAL ATTACKS DUE TO PAROXYSMAL VENTRICULAR FIBRILLATION. (PRESENTATION OF 1ST CASE IN ITALIAN PEDIATRIC LITERATURE)]. 61
14158288 1963
41
Paroxysmal ventricular fibrillation in the absence of other disease. 61
13459129 1957
42
[Study of a case of paroxysmal ventricular fibrillation]. 61
13399645 1956
43
Paroxysmal ventricular fibrillation producing Adams-Stokes syndrome; report of a case on quinidine therapy with spontaneous recovery. 61
13231194 1954
44
Paroxysmal ventricular fibrillation producing Adams-Stokes syndrome; report of case with review of literature. 61
14952058 1952

Variations for Paroxysmal Ventricular Fibrillation

ClinVar genetic disease variations for Paroxysmal Ventricular Fibrillation:

6 (show all 40)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SCN5A NM_198056.2(SCN5A):c.*1744C>G SNV Uncertain significance 345067 rs886058439 GRCh37: 3:38590068-38590068
GRCh38: 3:38548577-38548577
2 LOC110121269 , SCN5A NM_198056.2(SCN5A):c.2988C>T (p.Ala996=) SNV Uncertain significance 345121 rs781529391 GRCh37: 3:38622662-38622662
GRCh38: 3:38581171-38581171
3 SCN5A NM_198056.2(SCN5A):c.1870C>A (p.Leu624Ile) SNV Uncertain significance 345126 rs886058463 GRCh37: 3:38645223-38645223
GRCh38: 3:38603732-38603732
4 SCN5A NM_198056.2(SCN5A):c.*980C>A SNV Uncertain significance 345086 rs886058449 GRCh37: 3:38590832-38590832
GRCh38: 3:38549341-38549341
5 SCN5A NM_198056.2(SCN5A):c.*1673C>T SNV Uncertain significance 345072 rs886058443 GRCh37: 3:38590139-38590139
GRCh38: 3:38548648-38548648
6 SCN5A NM_198056.2(SCN5A):c.4267G>A (p.Asp1423Asn) SNV Uncertain significance 222810 rs746291609 GRCh37: 3:38598754-38598754
GRCh38: 3:38557263-38557263
7 SCN5A NM_198056.2(SCN5A):c.*1602G>T SNV Uncertain significance 345073 rs886058444 GRCh37: 3:38590210-38590210
GRCh38: 3:38548719-38548719
8 SCN5A NM_198056.2(SCN5A):c.*516G>T SNV Uncertain significance 345099 rs886058454 GRCh37: 3:38591296-38591296
GRCh38: 3:38549805-38549805
9 SCN5A NM_198056.2(SCN5A):c.*725C>A SNV Uncertain significance 345094 rs886058451 GRCh37: 3:38591087-38591087
GRCh38: 3:38549596-38549596
10 SCN5A NM_198056.2(SCN5A):c.687T>C (p.Thr229=) SNV Uncertain significance 345129 rs770390440 GRCh37: 3:38655250-38655250
GRCh38: 3:38613759-38613759
11 SCN5A NM_198056.2(SCN5A):c.*1731G>C SNV Uncertain significance 345068 rs569249327 GRCh37: 3:38590081-38590081
GRCh38: 3:38548590-38548590
12 SCN5A NM_198056.2(SCN5A):c.*634C>A SNV Uncertain significance 345098 rs886058453 GRCh37: 3:38591178-38591178
GRCh38: 3:38549687-38549687
13 SCN5A NM_198056.2(SCN5A):c.*945C>A SNV Uncertain significance 345089 rs886058450 GRCh37: 3:38590867-38590867
GRCh38: 3:38549376-38549376
14 SCN5A NM_198056.2(SCN5A):c.*6G>T SNV Uncertain significance 345110 rs776980213 GRCh37: 3:38591806-38591806
GRCh38: 3:38550315-38550315
15 SCN5A NM_000335.5(SCN5A):c.1569T>A (p.Arg523=) SNV Uncertain significance 165155 rs41313693 GRCh37: 3:38645524-38645524
GRCh38: 3:38604033-38604033
16 SCN5A NM_198056.2(SCN5A):c.*1836A>T SNV Uncertain significance 345066 rs886058438 GRCh37: 3:38589976-38589976
GRCh38: 3:38548485-38548485
17 SCN5A NM_198056.2(SCN5A):c.*1969C>T SNV Uncertain significance 345063 rs190416544 GRCh37: 3:38589843-38589843
GRCh38: 3:38548352-38548352
18 LOC110121269 , SCN5A NM_198056.2(SCN5A):c.3384C>T (p.Cys1128=) SNV Uncertain significance 345119 rs561922849 GRCh37: 3:38620831-38620831
GRCh38: 3:38579340-38579340
19 SCN5A NM_198056.2(SCN5A):c.*1705C>T SNV Uncertain significance 345069 rs886058440 GRCh37: 3:38590107-38590107
GRCh38: 3:38548616-38548616
20 SCN5A NM_198056.2(SCN5A):c.5945G>T (p.Arg1982Ile) SNV Uncertain significance 345113 rs774432823 GRCh37: 3:38591918-38591918
GRCh38: 3:38550427-38550427
21 LMNA NM_170707.4(LMNA):c.80C>G (p.Thr27Ser) SNV Uncertain significance 217834 rs863225270 GRCh37: 1:156084789-156084789
GRCh38: 1:156114998-156114998
22 DSP NM_004415.4(DSP):c.7186T>A (p.Tyr2396Asn) SNV Uncertain significance 217831 rs863225268 GRCh37: 6:7584681-7584681
GRCh38: 6:7584448-7584448
23 SCN5A NM_198056.2(SCN5A):c.*2149G>A SNV Uncertain significance 345060 rs114517792 GRCh37: 3:38589663-38589663
GRCh38: 3:38548172-38548172
24 SCN5A NM_198056.2(SCN5A):c.2259C>T (p.Asn753=) SNV Uncertain significance 345123 rs878911306 GRCh37: 3:38639223-38639223
GRCh38: 3:38597732-38597732
25 SCN5A NM_198056.2(SCN5A):c.*1691G>T SNV Uncertain significance 345071 rs886058442 GRCh37: 3:38590121-38590121
GRCh38: 3:38548630-38548630
26 SCN5A NM_198056.2(SCN5A):c.6033C>A (p.Asp2011Glu) SNV Uncertain significance 345111 rs886058459 GRCh37: 3:38591830-38591830
GRCh38: 3:38550339-38550339
27 SCN5A NM_198056.2(SCN5A):c.*1701G>T SNV Uncertain significance 345070 rs886058441 GRCh37: 3:38590111-38590111
GRCh38: 3:38548620-38548620
28 SCN5A NM_198056.2(SCN5A):c.*1443C>A SNV Uncertain significance 345078 rs886058445 GRCh37: 3:38590369-38590369
GRCh38: 3:38548878-38548878
29 LOC110121269 , SCN5A NM_198056.2(SCN5A):c.2815C>T (p.Leu939Phe) SNV Uncertain significance 345122 rs886058462 GRCh37: 3:38622835-38622835
GRCh38: 3:38581344-38581344
30 SCN5A NM_000335.5(SCN5A):c.1068T>C (p.Asp356=) SNV Uncertain significance 165156 rs41313703 GRCh37: 3:38648232-38648232
GRCh38: 3:38606741-38606741
31 SCN5A NM_198056.2(SCN5A):c.*296G>A SNV Uncertain significance 345103 rs886058456 GRCh37: 3:38591516-38591516
GRCh38: 3:38550025-38550025
32 LOC110121269 , SCN5A NM_000335.5(SCN5A):c.3360G>A (p.Ala1120=) SNV Uncertain significance 48300 rs9858585 GRCh37: 3:38620852-38620852
GRCh38: 3:38579361-38579361
33 SCN5A NM_198056.2(SCN5A):c.*73C>A SNV Uncertain significance 345109 rs886058458 GRCh37: 3:38591739-38591739
GRCh38: 3:38550248-38550248
34 SCN5A NM_198056.2(SCN5A):c.*1943C>A SNV Uncertain significance 345064 rs569552176 GRCh37: 3:38589869-38589869
GRCh38: 3:38548378-38548378
35 SCN5A NM_198056.2(SCN5A):c.1598G>A (p.Arg533His) SNV Uncertain significance 180512 rs146848219 GRCh37: 3:38645495-38645495
GRCh38: 3:38604004-38604004
36 SCN5A NM_198056.2(SCN5A):c.21T>A (p.Pro7=) SNV Uncertain significance 139038 rs587781157 GRCh37: 3:38674778-38674778
GRCh38: 3:38633287-38633287
37 LOC110121269 , SCN5A NM_198056.2(SCN5A):c.3228+6C>G SNV Uncertain significance 345120 rs368048551 GRCh37: 3:38622416-38622416
GRCh38: 3:38580925-38580925
38 CACNB2 NM_201596.3(CACNB2):c.380C>T (p.Ala127Val) SNV Likely benign 161209 rs200367454 GRCh37: 10:18787330-18787330
GRCh38: 10:18498401-18498401
39 SCN5A NM_000335.4(SCN5A):c.*1453dup Duplication Likely benign 345077 rs397763929 GRCh37: 3:38590358-38590359
GRCh38: 3:38548867-38548868
40 SCN5A NM_198056.2(SCN5A):c.*2145_*2146insGAGAAGAGAGTAGGAAAAAGGAGGG Insertion Likely benign 345061 rs45592631 GRCh37: 3:38589666-38589667
GRCh38: 3:38548175-38548176

Expression for Paroxysmal Ventricular Fibrillation

Search GEO for disease gene expression data for Paroxysmal Ventricular Fibrillation.

Pathways for Paroxysmal Ventricular Fibrillation

GO Terms for Paroxysmal Ventricular Fibrillation

Sources for Paroxysmal Ventricular Fibrillation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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