IVF
MCID: PRX010
MIFTS: 25

Paroxysmal Ventricular Fibrillation (IVF)

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Paroxysmal Ventricular Fibrillation

MalaCards integrated aliases for Paroxysmal Ventricular Fibrillation:

Name: Paroxysmal Ventricular Fibrillation 53
Paroxysmal Familial Ventricular Fibrillation 53 29 6 73
Ventricular Fibrillation, Idiopathic 53 55 6
Ventricular Fibrillation, Paroxysmal Familial 53
Idiopathic Ventricular Fibrillation 53
Ivf 53

Classifications:



External Ids:

UMLS 73 C0340493

Summaries for Paroxysmal Ventricular Fibrillation

MalaCards based summary : Paroxysmal Ventricular Fibrillation, also known as paroxysmal familial ventricular fibrillation, is related to idiopathic ventricular fibrillation, non brugada type and cardiac arrest. An important gene associated with Paroxysmal Ventricular Fibrillation is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5). The drugs Ticagrelor and Heparin have been mentioned in the context of this disorder. Affiliated tissues include heart, ovary and placenta.

Related Diseases for Paroxysmal Ventricular Fibrillation

Diseases in the Paroxysmal Ventricular Fibrillation family:

Ventricular Fibrillation, Paroxysmal Familial, 1 Ventricular Fibrillation, Paroxysmal Familial, 2

Diseases related to Paroxysmal Ventricular Fibrillation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 idiopathic ventricular fibrillation, non brugada type 31.7 DPP6 SCN5A
2 cardiac arrest 29.3 DPP6 SCN5A
3 ventricular fibrillation, paroxysmal familial, 1 12.1
4 ventricular fibrillation, paroxysmal familial, 2 11.9
5 brugada syndrome 11.9
6 premature ovarian failure 1 11.5
7 polycystic ovary syndrome 11.5
8 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 11.4
9 ventricular tachycardia, catecholaminergic polymorphic, 2 11.4
10 ventricular tachycardia, catecholaminergic polymorphic, 4 11.4
11 cardiac arrhythmia, ankyrin-b-related 11.2
12 ovarian hyperstimulation syndrome 10.5
13 infertility 10.4
14 endometriosis 10.4
15 progressive familial heart block, type ia 10.3
16 progressive familial heart block, type ib 10.3
17 right bundle branch block 10.3
18 adenomyosis 10.2
19 anxiety 10.2
20 body mass index quantitative trait locus 1 10.2
21 early repolarization associated with ventricular fibrillation 10.2
22 ectopic pregnancy 10.2
23 catecholaminergic polymorphic ventricular tachycardia 10.1
24 ovarian cyst 10.1
25 placenta disease 10.1
26 syncope 10.1
27 down syndrome 10.1
28 thrombophilia 10.1
29 cardiac conduction defect 10.0
30 wolff-parkinson-white syndrome 10.0
31 short qt syndrome 10.0
32 breast cancer 10.0
33 polycystic ovary syndrome 1 10.0
34 male infertility 10.0
35 azoospermia 10.0
36 hepatitis 9.9
37 hepatitis b 9.9
38 hypogonadotropic hypogonadism 9.9
39 endometritis 9.9
40 placenta accreta 9.9
41 arrhythmogenic right ventricular cardiomyopathy 9.9
42 left ventricular noncompaction 9.9
43 beckwith-wiedemann syndrome 9.8
44 hemifacial microsomia with radial defects 9.8
45 hemifacial microsomia 9.8
46 insulin-like growth factor i 9.8
47 ovarian cancer 1 9.8
48 chorioamnionitis 9.8
49 ovarian clear cell carcinoma 9.8
50 thrombosis 9.8

Graphical network of the top 20 diseases related to Paroxysmal Ventricular Fibrillation:



Diseases related to Paroxysmal Ventricular Fibrillation

Symptoms & Phenotypes for Paroxysmal Ventricular Fibrillation

Drugs & Therapeutics for Paroxysmal Ventricular Fibrillation

Drugs for Paroxysmal Ventricular Fibrillation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 307)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticagrelor Approved Phase 4 274693-27-5 9871419
2
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
3
Aspirin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-78-2 2244
4
Nicorandil Approved, Investigational Phase 4 65141-46-0 47528
5
Sotalol Approved Phase 4,Phase 3 959-24-0, 3930-20-9 5253
6
Amiodarone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1951-25-3 2157
7
Bisoprolol Approved Phase 4,Phase 3 66722-44-9 2405
8
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
9
Spironolactone Approved Phase 4,Phase 3 52-01-7, 1952-01-7 5833
10
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
11
Metoprolol Approved, Investigational Phase 4,Phase 2 37350-58-6, 51384-51-1 4171
12
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
13
Ramipril Approved Phase 4 87333-19-5 5362129
14
Captopril Approved Phase 4 62571-86-2 44093
15
Nebivolol Approved, Investigational Phase 4 99200-09-6, 152520-56-4, 118457-14-0 71301
16
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
17
Eplerenone Approved Phase 4,Phase 3 107724-20-9 443872 150310
18
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
19
Enalaprilat Approved Phase 4 76420-72-9 6917719
20
Dobutamine Approved Phase 4 34368-04-2 36811
21
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
22
Clopidogrel Approved Phase 4,Phase 3,Not Applicable 113665-84-2, 120202-66-6 60606
23
Tenecteplase Approved Phase 4,Phase 3 191588-94-0
24
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3 50-23-7 5754
25
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3 50-03-3
26
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 137-58-6 3676
27
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
28
Midazolam Approved, Illicit Phase 4,Phase 2 59467-70-8 4192
29
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2 2078-54-8 4943
30
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
31
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
32
Azithromycin Approved Phase 4 83905-01-5 55185 447043
33
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
34
Clarithromycin Approved Phase 4 81103-11-9 84029
35
Tazobactam Approved Phase 4 89786-04-9 123630
36
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
37
Polyestradiol phosphate Approved Phase 4 28014-46-2
38
Piperacillin Approved Phase 4 66258-76-2 43672
39
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
40
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
41
Ofloxacin Approved Phase 4 82419-36-1 4583
42
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
43
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
44
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
45 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
46
Prilocaine Approved Phase 4 721-50-6 4906
47
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
48
Empagliflozin Approved Phase 4 864070-44-0
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
50 Kava Approved, Investigational, Nutraceutical Phase 4,Not Applicable 9000-38-8

Interventional clinical trials:

(show top 50) (show all 332)
# Name Status NCT ID Phase Drugs
1 Effect of Nicorandil for the Patients of Acute ST Segment Elevation Myocardial Infarction Unknown status NCT02435797 Phase 4 Nicorandil;normal saline
2 Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Ischemic Ventricular Tachyarrhythmias Unknown status NCT02303639 Phase 4 Antiarrhythmic drug therapy
3 Magnesium to Reduce Implantable Cardioverter Defibrillator (ICD) Shocks and Improve Patient's Quality of Life. Unknown status NCT00282620 Phase 4 Magnesium L-lactate
4 Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding CRT Patients Unknown status NCT02200822 Phase 4 beta blockers;RAAS blockers
5 ADVANCE-D: Antitachycardia Pacing (ATP) Delivery for Painless Implantable Cardioverter Defibrillator (ICD) Therapy Completed NCT00147277 Phase 4
6 The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock Completed NCT00787800 Phase 4
7 VERRARI - "Are Ventricular Arrhythmic Episodes Reduced by Rate Response in ICDs?" Completed NCT00180427 Phase 4
8 Atorvastatin For The Reduction Of Ventricular Arrhythmias Completed NCT00457340 Phase 4 Atorvastatin 80mg
9 Remote Follow-up of Patients Receiving Implantable Cardioverter Defibrillator for Prophylactic Therapy Completed NCT00401466 Phase 4
10 ADVANCE CRT - D: Antitachycardia Pacing (ATP) Delivery for Painless Implantable Cardioverter Defibrillator (ICD) Therapy Completed NCT00147290 Phase 4
11 Trop-Shock DFT-testing Versus None Completed NCT01230086 Phase 4
12 Trial of Different Hypothermia Temperatures in Patients Recovered From Out-of-hospital Cardiac Arrest Completed NCT01155622 Phase 4
13 Transthoracic Incremental Monophasic Versus Biphasic by Emergency Responders (TIMBER) Completed NCT00101881 Phase 4
14 Influence of Home Monitoring on the Clinical Status of Heart Failure Patients With an Impaired Left Ventricular Function Completed NCT00538356 Phase 4
15 Acute Chest Pain Treatment and Evaluation (ACTION) Study Completed NCT00434564 Phase 4
16 RIGHT: Rhythm ID Going Head-to-Head Trial Completed NCT00148954 Phase 4
17 SMS: Substrate Modification Study in Patients Getting an Implantable Cardioverter Defibrillator (ICD) Completed NCT00170287 Phase 4
18 ASSURE Study - Arrhythmia Single Shock DFT Versus ULV: Risk Reduction Evaluation With ICD Implantations Completed NCT00231426 Phase 4
19 Clinical and Economical Interest of Endovascular Cooling in the Management of Cardiac Arrest (ICEREA Study) Completed NCT00392639 Phase 4
20 Fast VT Episodes Are Terminated by ATP One Shot Completed NCT00617578 Phase 4
21 Efficacy of Different Perioperative Statin Regimens on the Protection Against Post Coronary Artery Bypass Grafting Major Adverse Cardio-cerebral Events Completed NCT02706860 Phase 4 Atorvastatin
22 REFLEx Study (ENDOTAK RELIANCE G Evaluation of Handling and Electrical Performance Completed NCT00146822 Phase 4
23 'Effect of CRT on Defibrillation Threshold Estimates' Study Completed NCT00626093 Phase 4
24 TRUST: Lumos-T Safely RedUceS RouTine Office Device Follow-up Completed NCT00336284 Phase 4
25 Esmolol in Cardiac Surgery Completed NCT00959569 Phase 4 Esmolol;Placebo
26 Reduce Ventricular Pacing in Dual Chamber Implantable Cardioverter Defibrillators Using AutoIntrinsic Conduction Search Study Completed NCT00187239 Phase 4
27 Study to Verify Proper Detection of Supraventricular Tachyarrhythmia With Single-Lead Dual-Chamber Implantable Cardioverter-Defibrillators (ADRIA) Completed NCT00324662 Phase 4
28 Impact Of Eplerenone On Cardiovascular Outcomes In Patients Post Myocardial Infarction Completed NCT01176968 Phase 4 Eplerenone;Placebo
29 Temperature Control in Central Fever in the Neuro-ICU Completed NCT00751634 Phase 4
30 Survival of Patients With Primary Prophylactic ICD Indication Completed NCT00619593 Phase 4
31 Carvedilol Post-intervention Long-term Administration in Large-scale Trial Completed NCT01155635 Phase 4 Carvedilol;No Carvedilol
32 STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction Recruiting NCT02777580 Phase 4 Tenecteplase;Clopidogrel
33 Albumin in Cardiac Surgery Recruiting NCT02560519 Phase 4 Albumin solution;Ringers acetate solution
34 Safety of Sugammadex for the Reversal of Neuromuscular Blockade in American Society of Anesthesiologists (ASA) Class 3 or 4 Participants (MK-8616-145) Recruiting NCT03346057 Phase 4 Sugammadex 2 mg/kg;Sugammadex 4 mg/kg;Sugammadex 16 mg/kg;Neostigmine + Glycopyrrolate
35 Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia Recruiting NCT02735707 Phase 4 Hydrocortisone;Ceftriaxone;Moxifloxacin or Levofloxacin;Piperacillin tazobactam;Ceftaroline;Amoxicillin Clavulanate;Macrolide administered for 3 days;Macrolide administered for up to 14 days
36 Efficacy and Safety of Sugammadex Dosed According to Actual Body Weight (ABW) or Ideal Body Weight (IBW) in Reversal of Neuromuscular Blockade (NMB) in Morbidly Obese Participants (MK-8616-146) Recruiting NCT03346070 Phase 4 Sugammadex 2 mg/kg ABW;Sugammadex 2 mg/kg IBW;Sugammadex 4 mg/kg ABW;Sugammadex 4 mg/kg IBW;Neostigmine + Glycopyrrolate
37 Lidocaine vs Ketorolac for Management of Renal Colic in the Emergency Department Recruiting NCT03137498 Phase 4 Lidocaine;Ketorolac
38 EFFECT OF DEXMEDETOMİDİNE AND MİDAZOLAM SEDATİON ON HEART RATE VARİABİLİTY AFTER CORONARY ARTERY BYPASS GRAFT SURGERY Active, not recruiting NCT03601091 Phase 4 Precedex 200 MCG in 2 ML Injection;DORMICUM 5MG/5 ML
39 Empagliflozin Versus Placebo on the Rate of Arrhythmic Events in Heart Failure Patients Not yet recruiting NCT03271879 Phase 4 Empagliflozin at a dose of 10 mg/day
40 Low-dose Dexmedetomidine and Postoperative Delirium After Cardiac Surgery Not yet recruiting NCT03624595 Phase 4 Dexmedetomidine;Placebo
41 Effect of Ivabradine and Beta-blockers Combination Versus Beta-blockers Up-titration on Right Ventricular Pacing Suspended NCT01868880 Phase 4 Ivabradine plus beta-blocker (bisoprolol);betablocker titration
42 Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure Withdrawn NCT02767024 Phase 4 Sodium nitroprusside;Dobutamine;Furosemide
43 High Low Biphasic Energy Defibrillation (HiLoBED) Unknown status NCT00429611 Phase 3
44 BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease Unknown status NCT00123916 Phase 3 Benznidazole;Placebo
45 RAMYD Study - Evaluation of Arrhythmic Risk in Myotonic Dystrophy Unknown status NCT00127582 Phase 3
46 Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery Unknown status NCT02292667 Phase 3 PCA with Chlorhydrate of Morphine;Acetaminophen
47 Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia Completed NCT01401647 Phase 3 amiodarone;Lidocaine
48 Ranolazine Implantable Cardioverter-Defibrillator Trial Completed NCT01215253 Phase 3 Ranolazine
49 AED Use in Out-of-Hospital Cardiac Arrest: A New Algorithm Named "One Shock Per Minute" Completed NCT00139542 Phase 3
50 Fatty Acid Antiarrhythmia Trial (FAAT) Completed NCT00004559 Phase 3

Search NIH Clinical Center for Paroxysmal Ventricular Fibrillation

Genetic Tests for Paroxysmal Ventricular Fibrillation

Genetic tests related to Paroxysmal Ventricular Fibrillation:

# Genetic test Affiliating Genes
1 Paroxysmal Familial Ventricular Fibrillation 29

Anatomical Context for Paroxysmal Ventricular Fibrillation

MalaCards organs/tissues related to Paroxysmal Ventricular Fibrillation:

41
Heart, Ovary, Placenta

Publications for Paroxysmal Ventricular Fibrillation

Articles related to Paroxysmal Ventricular Fibrillation:

(show all 13)
# Title Authors Year
1
Paroxysmal ventricular fibrillation--a case report. ( 7118139 )
1982
2
Paroxysmal ventricular fibrillation in children. Long-term follow-up of three cases treated with beta-blocking agents. ( 920265 )
1977
3
Quinidine syncope. Paroxysmal ventricular fibrillation treated with lidocaine. ( 1059946 )
1975
4
Familial Q-T prolongation syndrome. Convulsive seizures and paroxysmal ventricular fibrillation. ( 4834545 )
1974
5
Paroxysmal familial ventricular fibrillation. ( 4834245 )
1974
6
Effect of propranolol on paroxysmal ventricular fibrillation. ( 5956507 )
1966
7
Quinidine-induced paroxysmal ventricular fibrillation treated with propranolol. ( 5941503 )
1966
8
PAROXYSMAL VENTRICULAR FIBRILLATION WITH SPONTANEOUS REVERSION TO SINUS RHYTHM. ( 14242165 )
1965
9
QUINIDINE SYNCOPE. PAROXYSMAL VENTRICULAR FIBRILLATION OCCURRING DURING TREATMENT OF CHRONIC ATRIAL ARRHYTHMIAS. ( 14197832 )
1964
10
PAROXYSMAL VENTRICULAR FIBRILLATION. ( 14180668 )
1964
11
Paroxysmal ventricular fibrillation in the absence of other disease. ( 13459129 )
1957
12
Paroxysmal ventricular fibrillation producing Adams-Stokes syndrome; report of a case on quinidine therapy with spontaneous recovery. ( 13231194 )
1954
13
Paroxysmal ventricular fibrillation producing Adams-Stokes syndrome; report of case with review of literature. ( 14952058 )
1952

Variations for Paroxysmal Ventricular Fibrillation

ClinVar genetic disease variations for Paroxysmal Ventricular Fibrillation:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CACNB2 NM_000724.3(CACNB2): c.215C> T (p.Ala72Val) single nucleotide variant Uncertain significance rs200367454 GRCh37 Chromosome 10, 18787330: 18787330
2 CACNB2 NM_000724.3(CACNB2): c.215C> T (p.Ala72Val) single nucleotide variant Uncertain significance rs200367454 GRCh38 Chromosome 10, 18498401: 18498401
3 LMNA NM_170707.3(LMNA): c.80C> G (p.Thr27Ser) single nucleotide variant Uncertain significance rs863225270 GRCh37 Chromosome 1, 156084789: 156084789
4 LMNA NM_170707.3(LMNA): c.80C> G (p.Thr27Ser) single nucleotide variant Uncertain significance rs863225270 GRCh38 Chromosome 1, 156114998: 156114998
5 DSP NM_004415.3(DSP): c.7186T> A (p.Tyr2396Asn) single nucleotide variant Uncertain significance rs863225268 GRCh37 Chromosome 6, 7584681: 7584681
6 DSP NM_004415.3(DSP): c.7186T> A (p.Tyr2396Asn) single nucleotide variant Uncertain significance rs863225268 GRCh38 Chromosome 6, 7584448: 7584448

Expression for Paroxysmal Ventricular Fibrillation

Search GEO for disease gene expression data for Paroxysmal Ventricular Fibrillation.

Pathways for Paroxysmal Ventricular Fibrillation

GO Terms for Paroxysmal Ventricular Fibrillation

Sources for Paroxysmal Ventricular Fibrillation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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