MCID: PRT001
MIFTS: 23

Partial Fetal Alcohol Syndrome

Categories: Mental diseases, Fetal diseases

Aliases & Classifications for Partial Fetal Alcohol Syndrome

MalaCards integrated aliases for Partial Fetal Alcohol Syndrome:

Name: Partial Fetal Alcohol Syndrome 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050666
UMLS 73 C3661483

Summaries for Partial Fetal Alcohol Syndrome

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in most, but not all, of the growth deficiency and/or craniofacial features of fetal alcohol syndrome including central nervous system dysfunction due to prenatal alcohol exposure.

MalaCards based summary : Partial Fetal Alcohol Syndrome is related to fetal alcohol syndrome and alcohol-related birth defect. An important gene associated with Partial Fetal Alcohol Syndrome is PFAS (Phosphoribosylformylglycinamidine Synthase). The drugs Ethanol and Choline have been mentioned in the context of this disorder. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Partial Fetal Alcohol Syndrome

Diseases related to Partial Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fetal alcohol syndrome 11.4
2 alcohol-related birth defect 11.1
3 fetal alcohol spectrum disorder 11.1
4 alcohol-related neurodevelopmental disorder 9.7
5 ideomotor apraxia 9.4 EP300 RTN4

Graphical network of the top 20 diseases related to Partial Fetal Alcohol Syndrome:



Diseases related to Partial Fetal Alcohol Syndrome

Symptoms & Phenotypes for Partial Fetal Alcohol Syndrome

GenomeRNAi Phenotypes related to Partial Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.44 PFAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.44 PFAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.44 EP300 GMDS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.44 GMDS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.44 GMDS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.44 GMDS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.44 PFAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.44 EP300
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.44 GMDS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.44 EP300 GMDS PFAS

MGI Mouse Phenotypes related to Partial Fetal Alcohol Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.7 PFAS EP300 FASN FEZF2 NEUROD2 NEUROG2
2 mortality/aging MP:0010768 9.61 ACER3 EP300 FASN FEZF2 NEUROD2 NEUROG2
3 nervous system MP:0003631 9.23 ACER3 EP300 FASN FEZF2 NEUROD2 NEUROG2

Drugs & Therapeutics for Partial Fetal Alcohol Syndrome

Drugs for Partial Fetal Alcohol Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2,Phase 1,Not Applicable 64-17-5 702
2
Choline Approved, Nutraceutical Phase 2,Phase 1 62-49-7 305
3 Anti-Infective Agents Phase 2,Phase 1,Not Applicable
4 Anti-Infective Agents, Local Phase 2,Phase 1,Not Applicable
5 Central Nervous System Depressants Phase 2,Phase 1,Not Applicable
6 Antimetabolites Phase 2,Phase 1
7 Gastrointestinal Agents Phase 2,Phase 1
8 Hypolipidemic Agents Phase 2,Phase 1
9 Lipid Regulating Agents Phase 2,Phase 1
10 Nootropic Agents Phase 2,Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
2 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2 Choline bitartrate
3 Parenting Training for Children With FASD Unknown status NCT02210455 Not Applicable

Search NIH Clinical Center for Partial Fetal Alcohol Syndrome

Genetic Tests for Partial Fetal Alcohol Syndrome

Anatomical Context for Partial Fetal Alcohol Syndrome

Publications for Partial Fetal Alcohol Syndrome

Articles related to Partial Fetal Alcohol Syndrome:

# Title Authors Year
1
Magnetic resonance imaging (MRI) findings among children with fetal alcohol syndrome (FAS), partial fetal alcohol syndrome (pFAS) and alcohol related neurodevelopmental disorders (ARND). ( 29688653 )
2016
2
Prevalence and characteristics of fetal alcohol syndrome and partial fetal alcohol syndrome in a Rocky Mountain Region City. ( 26321671 )
2015
3
Maternal risk factors predicting child physical characteristics and dysmorphology in fetal alcohol syndrome and partial fetal alcohol syndrome. ( 21658862 )
2011
4
Maternal risk factors for fetal alcohol syndrome and partial fetal alcohol syndrome in South Africa: a third study. ( 18336634 )
2008

Variations for Partial Fetal Alcohol Syndrome

Expression for Partial Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Partial Fetal Alcohol Syndrome.

Pathways for Partial Fetal Alcohol Syndrome

GO Terms for Partial Fetal Alcohol Syndrome

Biological processes related to Partial Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to calcium ion GO:0071277 9.26 NEUROD2 RTN4
2 axonal fasciculation GO:0007413 9.16 FEZF2 RTN4
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.13 EP300 NEUROD2 NEUROG2
4 nervous system development GO:0007399 9.02 EP300 FEZF2 NEUROD2 NEUROG2 RTN4

Molecular functions related to Partial Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 E-box binding GO:0070888 8.96 NEUROD2 NEUROG2
2 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 8.8 EP300 FEZF2 NEUROD2

Sources for Partial Fetal Alcohol Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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