MCID: PRT086
MIFTS: 27

Partial Hydatidiform Mole

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Partial Hydatidiform Mole

MalaCards integrated aliases for Partial Hydatidiform Mole:

Name: Partial Hydatidiform Mole 59
Incomplete Hydatidiform Mole 59
Incomplete Molar Pregnancy 59
Hydatidiform Mole, Partial 73
Partial Molar Pregnancy 59

Characteristics:

Orphanet epidemiological data:

59
partial hydatidiform mole
Inheritance: Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 59 ORPHA254693
UMLS via Orphanet 74 C0334529
ICD10 via Orphanet 34 O01.1
UMLS 73 C0334529

Summaries for Partial Hydatidiform Mole

MalaCards based summary : Partial Hydatidiform Mole, also known as incomplete hydatidiform mole, is related to hydatidiform mole, recurrent, 1 and gestational trophoblastic neoplasm. An important gene associated with Partial Hydatidiform Mole is NLRP7 (NLR Family Pyrin Domain Containing 7). The drugs Dihydrotachysterol and Nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include bone, placenta and testes.

Related Diseases for Partial Hydatidiform Mole

Diseases related to Partial Hydatidiform Mole via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 hydatidiform mole, recurrent, 1 32.1 KHDC3L NLRP7
2 gestational trophoblastic neoplasm 30.7 KHDC3L NLRP7
3 triploidy 29.8 KHDC3L NLRP7
4 trophoblastic neoplasm 29.5 KHDC3L NLRP7
5 hydatidiform mole, recurrent, 2 11.2
6 gestational trophoblastic tumor 10.4
7 choriocarcinoma 10.3
8 invasive mole 10.2
9 aging 10.1
10 placenta accreta 10.0
11 phenylketonuria 10.0
12 thyroiditis 10.0
13 ovarian hyperstimulation syndrome 10.0
14 tetraploidy 10.0
15 ectopic pregnancy 10.0
16 thrombosis 10.0
17 argyria 10.0
18 hydronephrosis 10.0
19 cervicitis 10.0
20 hermaphroditism 10.0
21 hyperthyroidism 9.8
22 pre-eclampsia 9.8
23 severe pre-eclampsia 9.8
24 eclampsia 9.8
25 germ cell and embryonal cancer 9.2 KHDC3L NLRP7
26 diabetes mellitus, transient neonatal, 1 9.0 KHDC3L NLRP7

Graphical network of the top 20 diseases related to Partial Hydatidiform Mole:



Diseases related to Partial Hydatidiform Mole

Symptoms & Phenotypes for Partial Hydatidiform Mole

Drugs & Therapeutics for Partial Hydatidiform Mole

Drugs for Partial Hydatidiform Mole (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dihydrotachysterol Approved Phase 2 67-96-9 5281010 5311071
2
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
3 Micronutrients Phase 2
4 Trace Elements Phase 2
5 Vitamins Phase 2
6 Antibodies Phase 2
7 Immunoglobulins Phase 2
8 Antibodies, Monoclonal Phase 2
9 Bone Density Conservation Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
2 Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias Recruiting NCT03135769 Phase 2 Avelumab administration at 10mg/kg
3 The French National Reference Centre of GTD Recruiting NCT02892877
4 Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles Recruiting NCT01008501

Search NIH Clinical Center for Partial Hydatidiform Mole

Genetic Tests for Partial Hydatidiform Mole

Anatomical Context for Partial Hydatidiform Mole

MalaCards organs/tissues related to Partial Hydatidiform Mole:

41
Bone, Placenta, Testes, Uterus, Thyroid, Liver, Lung

Publications for Partial Hydatidiform Mole

Articles related to Partial Hydatidiform Mole:

(show top 50) (show all 106)
# Title Authors Year
1
Hysteroscopic Management of Partial Hydatidiform Mole: A Novel Approach to an Old Disease. ( 29631009 )
2018
2
Partial hydatidiform mole in a phenylketonuria patient treated with sapropterin dihydrochloride. ( 27898272 )
2016
3
Diginyc partial hydatidiform mole with increased fetal nuchal translucency and ovarian hyperstimulation syndrome. ( 27328519 )
2016
4
Histological comparison of partial hydatidiform mole and trisomy gestation specimens. ( 27575970 )
2016
5
Clinical Presentation of Complete Hydatidiform Mole and Partial Hydatidiform Mole at a Regional Trophoblastic Disease Center in the United States Over the Past 2 Decades. ( 26588240 )
2016
6
Medical termination of a partial hydatidiform mole and coexisting fetus during the second trimester: A case report. ( 26788180 )
2015
7
[Diagnostic utility of STR genotyping for partial hydatidiform moles]. ( 26888503 )
2015
8
Partial hydatidiform mole with extensive angiomatoid vessel configuration in a first trimester miscarriage. ( 25844548 )
2015
9
Early Detection by Ultrasound of Partial Hydatidiform Mole With a Coexistent Live Fetus. ( 26726342 )
2015
10
Clinical utility of selective molecular genotyping for diagnosis of partial hydatidiform mole; a retrospective study from a regional trophoblastic disease unit. ( 25078332 )
2014
11
Partial hydatidiform mole following intracytoplasmic sperm injection and transfer of a cryopreserved-thawed blastocyst. ( 25093925 )
2014
12
Current clinical features of complete and partial hydatidiform mole in Sweden. ( 24597287 )
2014
13
In patients with neoplasia after partial hydatidiform mole immunohistochemistry or genotyping is essential to differentiate partial hydatidiform mole from complete mole, histologic examination is insufficient. ( 25340289 )
2014
14
Partial hydatidiform mole diagnosis in a cat: a case report. ( 23817014 )
2014
15
Partial hydatidiform mole: histologic parameters in correlation with DNA genotyping. ( 23518914 )
2013
16
Partial hydatidiform mole and coexisting viable twin pregnancy. ( 24300477 )
2013
17
Ultrasonographic signs of partial hydatidiform mole. ( 23848045 )
2013
18
Partial Hydatidiform Mole With False-Negative Urine Human Chorionic Gonadatropin Test in the Emergency Department. ( 24188605 )
2013
19
The diagnostic value of Ki-67, P53 and P63 in distinguishing partial Hydatidiform mole from hydropic abortion. ( 22218717 )
2012
20
Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization. ( 22740971 )
2012
21
Tetraploid partial hydatidiform mole: a case report and review of the literature. ( 22123726 )
2012
22
Twin pregnancy and partial hydatidiform mole following in vitro fertilization and embryos transfer: a novel case of placental mosaicism. ( 23253730 )
2012
23
Semen analysis by electron and fluorescence microscopy in a case of partial hydatidiform mole reveals a high incidence of abnormal morphology, diploidy, and tetraploidy. ( 21354560 )
2011
24
Preterm gestation along with partial hydatidiform mole and alive foetus. ( 22609510 )
2011
25
Recurrent partial hydatidiform mole. ( 22356040 )
2011
26
Four repetitive partial hydatidiform moles followed by malignant transformation to an invasive mole. ( 20846070 )
2010
27
Internal iliac artery embolisation in the treatment of uncontrolled haemorrhage associated with placenta accreta and partial hydatidiform mole. ( 20373939 )
2010
28
Dizygotic twin pregnancy with a normal fetus and a nodular embryo associated with a partial hydatidiform mole. ( 20151788 )
2010
29
Partial hydatidiform mole in septate uterus. ( 19655383 )
2009
30
Partial hydatidiform mole with a full-term infant. ( 19805991 )
2009
31
Recurrent partial hydatidiform mole, with a first twin pregnancy, after treatment with clomiphene citrate. ( 19499414 )
2009
32
Thyroid storm caused by a partial hydatidiform mole. ( 18352822 )
2008
33
Triplet pregnancy with partial hydatidiform mole coexisting with two fetuses: a case report. ( 18840171 )
2008
34
Partial hydatidiform mole in a 55-year-old woman: triploidy assessed by monochromosomal FISH on cultured villi. ( 19065381 )
2008
35
Intraplacental choriocarcinoma arising in a second trimester placenta with partial hydatidiform mole. ( 18317216 )
2008
36
Shortened duration of human chorionic gonadotrophin surveillance following complete or partial hydatidiform mole: evidence for revised protocol of a UK regional trophoblastic disease unit. ( 17516969 )
2007
37
Acute onset of severe hemolysis, elevated liver enzymes, and low platelet count syndrome in a patient with a partial hydatidiform mole at 17 weeks gestation. ( 16586230 )
2006
38
Histopathologic and immunohistochemical evaluation of blood vessels in complete and partial hydatidiform mole. ( 17253040 )
2006
39
Persistent gestational trophoblastic neoplasia after partial hydatidiform mole incidence and outcome. ( 17086803 )
2006
40
Twin pregnancy with partial hydatidiform mole and coexistent normal fetus. ( 16753704 )
2006
41
Recurrent partial hydatidiform mole: a report of a patient with three consecutive molar pregnancies. ( 16681793 )
2006
42
Overdiagnosis of complete and partial hydatidiform mole in tubal ectopic pregnancies. ( 15968202 )
2005
43
Placental site trophoblastic tumour arising from a partial hydatidiform mole. ( 16112308 )
2005
44
Vasculogenesis in complete and partial hydatidiform mole pregnancies studied with CD34 immunohistochemistry. ( 15878926 )
2005
45
Partial hydatidiform mole following the transfer of single frozen-thawed embryo subsequent to ICSI. ( 15511346 )
2004
46
Metastatic trophoblastic disease after an initial diagnosis of partial hydatidiform mole: genotyping and chromosome in situ hybridization analysis. ( 15042675 )
2004
47
Partial hydatidiform mole along with term gestation and alive baby. ( 15762073 )
2004
48
Twin pregnancy with partial hydatidiform mole and coexistent fetus. ( 15504073 )
2004
49
Placental mesenchymal dysplasia: a report of four cases with differentiation from partial hydatidiform mole. ( 14712956 )
2003
50
p57kip2 is useful in the classification and differential diagnosis of complete and partial hydatidiform moles. ( 12823708 )
2003

Variations for Partial Hydatidiform Mole

Expression for Partial Hydatidiform Mole

Search GEO for disease gene expression data for Partial Hydatidiform Mole.

Pathways for Partial Hydatidiform Mole

GO Terms for Partial Hydatidiform Mole

Sources for Partial Hydatidiform Mole

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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