Partial Hydatidiform Mole disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Partial Hydatidiform Mole

MalaCards integrated aliases for Partial Hydatidiform Mole:

Name: Partial Hydatidiform Mole ⁵⁸ ⁷⁵

Incomplete Hydatidiform Mole ⁵⁸

Incomplete Molar Pregnancy ⁵⁸

Hydatidiform Mole, Partial ⁷¹

Partial Molar Pregnancy ⁵⁸

Characteristics:

Age Of Onset:

Adult ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Pregnancy, childbirth and the puerperium

Pregnancy with abortive outcome

Hydatidiform mole

Incomplete and partial hydatidiform mole

Orphanet: ⁵⁸

Rare gynaecological and obstetric diseases

External Ids:

ICD10 via Orphanet ³² O01.1

UMLS via Orphanet ⁷² C0334529

Orphanet ⁵⁸ ORPHA254693

UMLS ⁷¹ C0334529

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Summaries for Partial Hydatidiform Mole

Orphanet: ⁵⁸ A form of hydatiform mole characterized by abnormal hyperplastic trophoblasts and hydropic villi due to fertilization of a normal ovocyte by two spermatozoa or one abnormal spermatozoon (allowing for some fetal development), and that manifests with vaginal bleeding accompanied by nausea and frequent vomiting, hyperemesis gravidarum, hyperthyroidism and risk of spontaneous miscarriage.

MalaCards based summary: Partial Hydatidiform Mole, also known as incomplete hydatidiform mole, is related to hydatidiform mole, recurrent, 1 and gestational trophoblastic neoplasm. An important gene associated with Partial Hydatidiform Mole is KHDC3L (KH Domain Containing 3 Like, Subcortical Maternal Complex Member). Affiliated tissues include placenta, uterus and thyroid.

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Related Diseases for Partial Hydatidiform Mole

Diseases related to Partial Hydatidiform Mole via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)

#	Related Disease	Score	Top Affiliating Genes
1	hydatidiform mole, recurrent, 1	32.0	NLRP7 KHDC3L
2	gestational trophoblastic neoplasm	31.3	NLRP7 KHDC3L
3	triploidy	31.0	NLRP7 KHDC3L
4	trophoblastic neoplasm	30.3	NLRP7 KHDC3L
5	placental site trophoblastic tumor	29.8	NLRP7 KHDC3L
6	beckwith-wiedemann syndrome	29.4	NLRP7 KHDC3L
7	hydatidiform mole, recurrent, 2	11.3
8	choriocarcinoma	10.7
9	pre-eclampsia	10.6
10	invasive mole	10.5
11	graves disease 1	10.5
12	hyperthyroidism	10.4
13	eclampsia	10.3
14	down syndrome	10.3
15	severe pre-eclampsia	10.3
16	ectopic pregnancy	10.3
17	gestational choriocarcinoma	10.3
18	tetraploidy	10.3
19	gastroschisis	10.1
20	deficiency anemia	10.1
21	neural tube defects	10.1
22	phenylketonuria	10.1
23	spastic ataxia, charlevoix-saguenay type	10.1
24	orofaciodigital syndrome viii	10.1
25	46,xx sex reversal 1	10.1
26	ovarian hyperstimulation syndrome	10.1
27	thrombosis	10.1
28	oligoasthenoteratozoospermia	10.1
29	meningocele	10.1
30	microcephaly	10.1
31	hydronephrosis	10.1
32	thyroid crisis	10.1
33	adhesions of uterus	10.1
34	amenorrhea	10.1
35	thrombocytopenia	10.1
36	hermaphroditism	10.1
37	placenta accreta	10.1
38	ovarian cyst	10.1
39	47 xxx syndrome	10.1
40	maternal hyperphenylalaninemia	10.1
41	septate uterus	10.1
42	hyperphenylalaninemia	10.1
43	preeclampsia/eclampsia 1	10.0
44	glomerulonephritis	10.0
45	proliferative glomerulonephritis	10.0
46	hypothyroidism, congenital, nongoitrous, 1	10.0
47	myelomeningocele	10.0
48	omphalocele	10.0
49	keratomalacia	10.0
50	adult respiratory distress syndrome	10.0

Graphical network of the top 20 diseases related to Partial Hydatidiform Mole:

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Symptoms & Phenotypes for Partial Hydatidiform Mole

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Drugs & Therapeutics for Partial Hydatidiform Mole

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase II Study to Determine the Response to Second Curettage as Initial Management for Persistent Low Risk, Non-metastatic Gestational Trophoblastic Neoplasia	Completed	NCT00521118	Phase 2

Search NIH Clinical Center for Partial Hydatidiform Mole

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Genetic Tests for Partial Hydatidiform Mole

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Anatomical Context for Partial Hydatidiform Mole

Organs/tissues related to Partial Hydatidiform Mole:

MalaCards : Placenta, Uterus, Thyroid, Lung, Ovary, Liver

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Publications for Partial Hydatidiform Mole

Articles related to Partial Hydatidiform Mole:

(show top 50) (show all 471)

#	Title	Authors	PMID	Year
1	The diagnostic value and accuracy of ultrasound in diagnosing hydatidiform mole: A systematic review and meta-analysis of the literature. ⁶²	Newhouse I...Szczepura K	35785640	2022
2	Risk factors for gestational trophoblastic neoplasia development of singleton normal fetus with partial hydatidiform mole pregnancy: A retrospective cohort and literature review. ⁶²	Zhong L...Wang D	36328803	2022
3	Partial Molar Pregnancy With Normal Karyotype. ⁶²	Al Ghadeer HA...Alkishi BM	36465796	2022
4	Advances in diagnostics and management of gestational trophoblastic disease. ⁶²	Lukinovic N...Knez J	36286620	2022
5	Twin pregnancy with complete hydatidiform mole and co-existing fetus: A report of 15 cases with a clinicopathological analysis and DNA genotyping. ⁶²	Lu B...Xu E	36095920	2022
6	[Twin gestation with complete hydatidiform mole and a coexisting live fetus: A case report and review of the literature]. ⁶²	Moscoso O...Reques A	36075658	2022
7	[GESTATIONAL TROPHOBLASTIC DISEASE: THE NEED FOR CENTRALIZATION OF TREATMENT CENTERS IN ISRAEL]. ⁶²	Marom I...Segev Y	35979568	2022
8	Changes in diagnostic sensitivity, incidence and presentation of complete and partial hydatidiform mole over the years. ⁶²	Aiob A...Lowenstein L	35640442	2022
9	Partial mole with coexistent live fetus: A systematic review of case reports ⁶²	Mangla M...Khoiwal K	35642357	2022
10	Experience of women on the Irish National Gestational Trophoblastic Disease Registry. ⁶²	Joyce CM...O'Donoghue K	35367922	2022
11	Obstetrical and oncological outcomes of twin pregnancies with hydatidiform mole and coexisting fetus. ⁶²	Liang H...Wu RJ	35595437	2022
12	Gestational trophoblastic disease and associated factors among women experiencing first trimester pregnancy loss at a regional referral hospital in central Tanzania: a cross-sectional study. ⁶²	Mdoe MB...Mwampagatwa I	35394041	2022
13	Prenatal Diagnosis and Fetal Outcome with Mosaic Genome-Wide Uniparental Disomy. ⁶²	Jawahir-Schonauer J...Romero VC	35981514	2022
14	A Twin Pregnancy of Partial Mole Coexisting with a Normal Fetus: A Case Report. ⁶²	Tolcha FD...Tadesse TM	35706462	2022
15	Partial Molar Pregnancy Presenting as a Tubal Ectopic Pregnancy. ⁶²	Ayyash M...Swain M	35845975	2022
16	[Twin gestation with regressive partial hydatidiform mole and coexisting live fetus]. ⁶²	Barinova IV...Beskorovaynaya TS	35417948	2022
17	Partial hydatidiform mole pregnancy ended in full-term delivery of a normal infant: a case presentation. ⁶²	Qu QH...Hao LJ	36105037	2022
18	"While there is p57, there is hope." The past and the present of diagnosis in first trimester abortions: Diagnostic dilemmas and algorithmic approaches. A review. ⁶²	Giacometti C...Ludwig K	33714612	2021
19	Sudden fetal death with placental mesenchymal dysplasia complicated by placenta previa. ⁶²	Tanimura K...Terai Y	34404116	2021
20	Surveillance for gestational trophoblastic neoplasia following molar pregnancy: a cost-effectiveness analysis. ⁶²	Albright BB...Havrilesky LJ	34058170	2021
21	Application of next-generation sequencing to preimplantation genetic testing for recurrent hydatidiform mole patients. ⁶²	Yang J...Zhi X	34608573	2021
22	Placental spectrum features between mesenchymal dysplasia and partial hydatidiform mole coexisting with a live fetus. ⁶²	Marinho M...Brito C	34416021	2021
23	When a vesicular placenta meets a live fetus: case report of twin pregnancy with a partial hydatidiform mole. ⁶²	Lin M...Luo Y	34645420	2021
24	Triploid pregnancy-Clinical implications. ⁶²	Massalska D...Roszkowski T	34031868	2021
25	Partial molar pregnancy with a normal live fetus and umbilical cord abnormalities: A novel association with long-term follow-up: A case report. ⁶²	Ghalandarpoor Attar SN...Ghalandarpoor Attar SM	34552746	2021
26	The Contribution of QF-PCR and Pathology Studies in the Diagnosis of Diandric Triploidy/Partial Mole. ⁶²	Benitez L...Borrell A	34679509	2021
27	[Tetraploid partial hydatidiform mole: report of a case]. ⁶²	Wu Y...Zeng SM	34344088	2021
28	Spontaneous uterine rupture during the first trimester of a partial molar pregnancy in a scar uterus: A rare case report. ⁶²	El Miski F...Bouhya S	34325299	2021
29	Video Hysteroscopy in the Diagnosis of Molar Pregnancy in two Challenging Situations: Complete Mole with Normal hCG and Partial Mole with Early Gestational Age. ⁶²	Braga A...Berkowitz RS	33556583	2021
30	Genetics of gestational trophoblastic disease. ⁶²	Fisher RA...Maher GJ	33685819	2021
31	Partial Hydatidiform Mole with a Coexistent Twin Pregnancy: A Successful Outcome with Expectant Management. ⁶²	Banerjee A...Marsden L	35589517	2021
32	Partial Hydatidiform Mole in an Ectopic Tubal Pregnancy. ⁶²	Hasan A...Nafie KM	34258118	2021
33	Refined diagnosis of hydatidiform moles with p57 immunohistochemistry and molecular genotyping: updated analysis of a prospective series of 2217 cases. ⁶²	Xing D...Ronnett BM	33024305	2021
34	Variants in Maternal Effect Genes and Relaxed Imprinting Control in a Special Placental Mesenchymal Dysplasia Case with Mild Trophoblast Hyperplasia. ⁶²	Huang TC...Kuo PL	34068021	2021
35	Obstetrics outcomes after complete and partial molar pregnancy: Review of the literature and meta-analysis. ⁶²	Capozzi VA...Berretta R	33550107	2021
36	Normalisation of human chorionic gonadotrophin (hCG) levels in a patient with partial molar pregnancy with a uterine mass without chemotherapy: impact of using herbal remedies. ⁶²	Ismail N...Hua GS	33818024	2021
37	Placental mesenchymal dysplasia - morphology and differential diagnosis. ⁶²	Daumova M...Martinek P	35042352	2021
38	[Appearance of partial molar pregnancy]. ⁶²	Mekni K...El Fkih C	34512856	2021
39	Partial hydatidiform moles with unclear histopathological profile - importance of genetic diagnostics. ⁶²	Gergely Lajos...Priscakova Petra	35038875	2021
40	P57kip2 immunohistochemical marker as a diagnostic tool for cases of hydatidiform moles in a tertiary health facility in Southwestern Nigeria. ⁶²	Awosusi BL...Okolo CA	33154286	2020
41	A Case Report of Twin Pregnancy with Hydatidiform Mole and Co-existing Live Fetus. ⁶²	Ray A...Kumari S	32952514	2020
42	Molar Changes With a Normal Viable Fetus: A Case Report. ⁶²	Farazestanian M...Kamandi S	33603814	2020
43	[Partial molar pregnancy with live fetus complicated by intrauterine growth restriction and severe preeclampsia. Case report and review of the literature]. ⁶²	Camacho-Montano AM...Nino-Alba R	33247892	2020
44	Spontaneous Ovarian Hyperstimulation Syndrome in a Partial Molar Pregnancy With Early Onset Severe Pre-eclampsia at 15 Weeks Gestation. ⁶²	Davies MJ...Cox Bauer CM	32420602	2020
45	Ultrasound diagnosis of complete and partial hydatidiform moles in early pregnancy failure: An inter-observer study. ⁶²	Jauniaux E...Jurkovic D	32792066	2020
46	p57-discordant villi in hydropic products of conception: a clinicopathological study of 70 cases. ⁶²	Gaillot-Durand L...Allias F	32387104	2020
47	Determination of morphologic and immunohistochemical stain (p57 kip2) discrepancy of complete and partial hydatidiform mole by using microsatellite genotyping. ⁶²	Oranratanaphan S...Lertkhachonsuk R	32653131	2020
48	A unique case of recurrent fetal cystic hygroma: first fetus with an inherited heteromorphism of chromosome 1 (1qh+) and the second fetus with 69XXX triploidy. ⁶²	Tica OS...Tica VI	33817737	2020
49	Prevalence of Partial Hydatidiform Mole in Products of Conception From Gestations With Fetal Triploidy Merits Reflex Genotype Testing Independent of the Morphologic Appearance of the Chorionic Villi. ⁶²	Han LM...Rabban JT	32205485	2020
50	Placental Mesenchymal Dysplasia: Ultrasound Characteristics and Diagnostic Pitfalls. ⁶²	Psarris A...Daskalakis G	32666037	2020

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Genes for Partial Hydatidiform Mole

Genes related to Partial Hydatidiform Mole (2 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	KHDC3L	KH Domain Containing 3 Like, Subcortical Maternal Complex Member	Protein Coding	350	Causative germline mutation ⁵⁸	24533231
2	NLRP7	NLR Family Pyrin Domain Containing 7	Protein Coding	350	Causative germline mutation ⁵⁸	19246479 24533231

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Variations for Partial Hydatidiform Mole

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Expression for Partial Hydatidiform Mole

Search GEO for disease gene expression data for Partial Hydatidiform Mole.

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Pathways for Partial Hydatidiform Mole

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GO Terms for Partial Hydatidiform Mole

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Sources for Partial Hydatidiform Mole

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: PRT086 MIFTS: 24	Partial Hydatidiform Mole Categories: Rare diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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