MCID: PRT086
MIFTS: 24

Partial Hydatidiform Mole

Categories: Rare diseases, Reproductive diseases
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Aliases & Classifications for Partial Hydatidiform Mole

MalaCards integrated aliases for Partial Hydatidiform Mole:

Name: Partial Hydatidiform Mole 58 75
Incomplete Hydatidiform Mole 58
Incomplete Molar Pregnancy 58
Hydatidiform Mole, Partial 71
Partial Molar Pregnancy 58

Characteristics:


Age Of Onset:

Adult 58

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

ICD10 via Orphanet 32 O01.1
UMLS via Orphanet 72 C0334529
Orphanet 58 ORPHA254693
UMLS 71 C0334529

Summaries for Partial Hydatidiform Mole

Orphanet: 58 A form of hydatiform mole characterized by abnormal hyperplastic trophoblasts and hydropic villi due to fertilization of a normal ovocyte by two spermatozoa or one abnormal spermatozoon (allowing for some fetal development), and that manifests with vaginal bleeding accompanied by nausea and frequent vomiting, hyperemesis gravidarum, hyperthyroidism and risk of spontaneous miscarriage.

MalaCards based summary: Partial Hydatidiform Mole, also known as incomplete hydatidiform mole, is related to hydatidiform mole, recurrent, 1 and gestational trophoblastic neoplasm. An important gene associated with Partial Hydatidiform Mole is KHDC3L (KH Domain Containing 3 Like, Subcortical Maternal Complex Member). Affiliated tissues include placenta, uterus and thyroid.

Related Diseases for Partial Hydatidiform Mole

Diseases related to Partial Hydatidiform Mole via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 hydatidiform mole, recurrent, 1 32.0 NLRP7 KHDC3L
2 gestational trophoblastic neoplasm 31.3 NLRP7 KHDC3L
3 triploidy 31.0 NLRP7 KHDC3L
4 trophoblastic neoplasm 30.3 NLRP7 KHDC3L
5 placental site trophoblastic tumor 29.8 NLRP7 KHDC3L
6 beckwith-wiedemann syndrome 29.4 NLRP7 KHDC3L
7 hydatidiform mole, recurrent, 2 11.3
8 choriocarcinoma 10.7
9 pre-eclampsia 10.6
10 invasive mole 10.5
11 graves disease 1 10.5
12 hyperthyroidism 10.4
13 eclampsia 10.3
14 down syndrome 10.3
15 severe pre-eclampsia 10.3
16 ectopic pregnancy 10.3
17 gestational choriocarcinoma 10.3
18 tetraploidy 10.3
19 gastroschisis 10.1
20 deficiency anemia 10.1
21 neural tube defects 10.1
22 phenylketonuria 10.1
23 spastic ataxia, charlevoix-saguenay type 10.1
24 orofaciodigital syndrome viii 10.1
25 46,xx sex reversal 1 10.1
26 ovarian hyperstimulation syndrome 10.1
27 thrombosis 10.1
28 oligoasthenoteratozoospermia 10.1
29 meningocele 10.1
30 microcephaly 10.1
31 hydronephrosis 10.1
32 thyroid crisis 10.1
33 adhesions of uterus 10.1
34 amenorrhea 10.1
35 thrombocytopenia 10.1
36 hermaphroditism 10.1
37 placenta accreta 10.1
38 ovarian cyst 10.1
39 47 xxx syndrome 10.1
40 maternal hyperphenylalaninemia 10.1
41 septate uterus 10.1
42 hyperphenylalaninemia 10.1
43 preeclampsia/eclampsia 1 10.0
44 glomerulonephritis 10.0
45 proliferative glomerulonephritis 10.0
46 hypothyroidism, congenital, nongoitrous, 1 10.0
47 myelomeningocele 10.0
48 omphalocele 10.0
49 keratomalacia 10.0
50 adult respiratory distress syndrome 10.0

Graphical network of the top 20 diseases related to Partial Hydatidiform Mole:



Diseases related to Partial Hydatidiform Mole

Symptoms & Phenotypes for Partial Hydatidiform Mole

Drugs & Therapeutics for Partial Hydatidiform Mole

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study to Determine the Response to Second Curettage as Initial Management for Persistent Low Risk, Non-metastatic Gestational Trophoblastic Neoplasia Completed NCT00521118 Phase 2

Search NIH Clinical Center for Partial Hydatidiform Mole

Genetic Tests for Partial Hydatidiform Mole

Anatomical Context for Partial Hydatidiform Mole

Organs/tissues related to Partial Hydatidiform Mole:

MalaCards : Placenta, Uterus, Thyroid, Lung, Ovary, Liver

Publications for Partial Hydatidiform Mole

Articles related to Partial Hydatidiform Mole:

(show top 50) (show all 471)
# Title Authors PMID Year
1
The diagnostic value and accuracy of ultrasound in diagnosing hydatidiform mole: A systematic review and meta-analysis of the literature. 62
35785640 2022
2
Risk factors for gestational trophoblastic neoplasia development of singleton normal fetus with partial hydatidiform mole pregnancy: A retrospective cohort and literature review. 62
36328803 2022
3
Partial Molar Pregnancy With Normal Karyotype. 62
36465796 2022
4
Advances in diagnostics and management of gestational trophoblastic disease. 62
36286620 2022
5
Twin pregnancy with complete hydatidiform mole and co-existing fetus: A report of 15 cases with a clinicopathological analysis and DNA genotyping. 62
36095920 2022
6
[Twin gestation with complete hydatidiform mole and a coexisting live fetus: A case report and review of the literature]. 62
36075658 2022
7
[GESTATIONAL TROPHOBLASTIC DISEASE: THE NEED FOR CENTRALIZATION OF TREATMENT CENTERS IN ISRAEL]. 62
35979568 2022
8
Changes in diagnostic sensitivity, incidence and presentation of complete and partial hydatidiform mole over the years. 62
35640442 2022
9
Partial mole with coexistent live fetus: A systematic review of case reports 62
35642357 2022
10
Experience of women on the Irish National Gestational Trophoblastic Disease Registry. 62
35367922 2022
11
Obstetrical and oncological outcomes of twin pregnancies with hydatidiform mole and coexisting fetus. 62
35595437 2022
12
Gestational trophoblastic disease and associated factors among women experiencing first trimester pregnancy loss at a regional referral hospital in central Tanzania: a cross-sectional study. 62
35394041 2022
13
Prenatal Diagnosis and Fetal Outcome with Mosaic Genome-Wide Uniparental Disomy. 62
35981514 2022
14
A Twin Pregnancy of Partial Mole Coexisting with a Normal Fetus: A Case Report. 62
35706462 2022
15
Partial Molar Pregnancy Presenting as a Tubal Ectopic Pregnancy. 62
35845975 2022
16
[Twin gestation with regressive partial hydatidiform mole and coexisting live fetus]. 62
35417948 2022
17
Partial hydatidiform mole pregnancy ended in full-term delivery of a normal infant: a case presentation. 62
36105037 2022
18
"While there is p57, there is hope." The past and the present of diagnosis in first trimester abortions: Diagnostic dilemmas and algorithmic approaches. A review. 62
33714612 2021
19
Sudden fetal death with placental mesenchymal dysplasia complicated by placenta previa. 62
34404116 2021
20
Surveillance for gestational trophoblastic neoplasia following molar pregnancy: a cost-effectiveness analysis. 62
34058170 2021
21
Application of next-generation sequencing to preimplantation genetic testing for recurrent hydatidiform mole patients. 62
34608573 2021
22
Placental spectrum features between mesenchymal dysplasia and partial hydatidiform mole coexisting with a live fetus. 62
34416021 2021
23
When a vesicular placenta meets a live fetus: case report of twin pregnancy with a partial hydatidiform mole. 62
34645420 2021
24
Triploid pregnancy-Clinical implications. 62
34031868 2021
25
Partial molar pregnancy with a normal live fetus and umbilical cord abnormalities: A novel association with long-term follow-up: A case report. 62
34552746 2021
26
The Contribution of QF-PCR and Pathology Studies in the Diagnosis of Diandric Triploidy/Partial Mole. 62
34679509 2021
27
[Tetraploid partial hydatidiform mole: report of a case]. 62
34344088 2021
28
Spontaneous uterine rupture during the first trimester of a partial molar pregnancy in a scar uterus: A rare case report. 62
34325299 2021
29
Video Hysteroscopy in the Diagnosis of Molar Pregnancy in two Challenging Situations: Complete Mole with Normal hCG and Partial Mole with Early Gestational Age. 62
33556583 2021
30
Genetics of gestational trophoblastic disease. 62
33685819 2021
31
Partial Hydatidiform Mole with a Coexistent Twin Pregnancy: A Successful Outcome with Expectant Management. 62
35589517 2021
32
Partial Hydatidiform Mole in an Ectopic Tubal Pregnancy. 62
34258118 2021
33
Refined diagnosis of hydatidiform moles with p57 immunohistochemistry and molecular genotyping: updated analysis of a prospective series of 2217 cases. 62
33024305 2021
34
Variants in Maternal Effect Genes and Relaxed Imprinting Control in a Special Placental Mesenchymal Dysplasia Case with Mild Trophoblast Hyperplasia. 62
34068021 2021
35
Obstetrics outcomes after complete and partial molar pregnancy: Review of the literature and meta-analysis. 62
33550107 2021
36
Normalisation of human chorionic gonadotrophin (hCG) levels in a patient with partial molar pregnancy with a uterine mass without chemotherapy: impact of using herbal remedies. 62
33818024 2021
37
Placental mesenchymal dysplasia - morphology and differential diagnosis. 62
35042352 2021
38
[Appearance of partial molar pregnancy]. 62
34512856 2021
39
Partial hydatidiform moles with unclear histopathological profile - importance of genetic diagnostics. 62
35038875 2021
40
P57kip2 immunohistochemical marker as a diagnostic tool for cases of hydatidiform moles in a tertiary health facility in Southwestern Nigeria. 62
33154286 2020
41
A Case Report of Twin Pregnancy with Hydatidiform Mole and Co-existing Live Fetus. 62
32952514 2020
42
Molar Changes With a Normal Viable Fetus: A Case Report. 62
33603814 2020
43
[Partial molar pregnancy with live fetus complicated by intrauterine growth restriction and severe preeclampsia. Case report and review of the literature]. 62
33247892 2020
44
Spontaneous Ovarian Hyperstimulation Syndrome in a Partial Molar Pregnancy With Early Onset Severe Pre-eclampsia at 15 Weeks Gestation. 62
32420602 2020
45
Ultrasound diagnosis of complete and partial hydatidiform moles in early pregnancy failure: An inter-observer study. 62
32792066 2020
46
p57-discordant villi in hydropic products of conception: a clinicopathological study of 70 cases. 62
32387104 2020
47
Determination of morphologic and immunohistochemical stain (p57 kip2) discrepancy of complete and partial hydatidiform mole by using microsatellite genotyping. 62
32653131 2020
48
A unique case of recurrent fetal cystic hygroma: first fetus with an inherited heteromorphism of chromosome 1 (1qh+) and the second fetus with 69XXX triploidy. 62
33817737 2020
49
Prevalence of Partial Hydatidiform Mole in Products of Conception From Gestations With Fetal Triploidy Merits Reflex Genotype Testing Independent of the Morphologic Appearance of the Chorionic Villi. 62
32205485 2020
50
Placental Mesenchymal Dysplasia: Ultrasound Characteristics and Diagnostic Pitfalls. 62
32666037 2020

Variations for Partial Hydatidiform Mole

Expression for Partial Hydatidiform Mole

Search GEO for disease gene expression data for Partial Hydatidiform Mole.

Pathways for Partial Hydatidiform Mole

GO Terms for Partial Hydatidiform Mole

Sources for Partial Hydatidiform Mole

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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