MCID: PRT015
MIFTS: 36

Partial Third-Nerve Palsy

Categories: Neuronal diseases

Aliases & Classifications for Partial Third-Nerve Palsy

MalaCards integrated aliases for Partial Third-Nerve Palsy:

Name: Partial Third-Nerve Palsy 12 15 70
Third or Oculomotor Nerve Palsy, Partial 12
Third Nerve Palsy with Pupil Sparing 12
Oculomotor Nerve Paralysis 70
Partial Third Nerve Palsy 12
Oculomotor Nerve Diseases 44

Classifications:



External Ids:

Disease Ontology 12 DOID:10864
ICD9CM 34 378.51
MeSH 44 D015840
SNOMED-CT 67 194118007
UMLS 70 C0028866 C0271370

Summaries for Partial Third-Nerve Palsy

MalaCards based summary : Partial Third-Nerve Palsy, also known as third or oculomotor nerve palsy, partial, is related to hypertropia and strabismus, and has symptoms including ophthalmoplegia, ophthalmoparesis and setting-sun eye phenomenon. An important gene associated with Partial Third-Nerve Palsy is NT5C3A (5'-Nucleotidase, Cytosolic IIIA), and among its related pathways/superpathways are G12-G13 in Cellular Signaling and Glioblastoma Multiforme. Affiliated tissues include pituitary, eye and bone, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Partial Third-Nerve Palsy

Diseases related to Partial Third-Nerve Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 hypertropia 30.2 ROBO3 PHOX2A KIF21A CHN1
2 strabismus 30.0 TUBB2B SALL4 ROBO3 PHOX2A KIF21A CHN1
3 hypotropia 30.0 SALL4 ROBO3 PHOX2A KIF21A CHN1
4 exotropia 30.0 SALL4 ROBO3 PHOX2A KIF21A CHN1
5 fibrous dysplasia 29.8 PRL IGF1 GH1
6 esotropia 29.8 TUBB2B SALL4 ROBO3 PHOX2A KIF21A CHN1
7 myotonic cataract 10.3 PHOX2A KIF21A
8 ametropic amblyopia 10.3 PHOX2A CHN1
9 marcus gunn phenomenon 10.3 PHOX2A KIF21A
10 suppression amblyopia 10.3 PHOX2A CHN1
11 fibrosis of extraocular muscles, congenital, 2 10.3 PHOX2A KIF21A
12 lagophthalmos 10.3 PHOX2A KIF21A
13 abducens nerve disease 10.3 PRL CHN1
14 fibrous dysplasia/mccune-albright syndrome 10.3 PRL GH1
15 abnormal retinal correspondence 10.3 NT5C3A KIF21A CHN1
16 binocular vision disease 10.3 NT5C3A KIF21A CHN1
17 adenohypophysitis 10.3 PRL GH1
18 diencephalic astrocytoma 10.3 SALL4 GH1
19 chromophobe adenoma 10.3 PRL GH1
20 gigantism 10.2 PRL GH1
21 tsh producing pituitary tumor 10.2 PRL GH1
22 microphthalmia, isolated 5 10.2 TUBB2B PHOX2A KIF21A
23 hypothyroidism, congenital, nongoitrous, 4 10.2 PRL GH1
24 pituitary-dependent cushing's disease 10.2 PRL GH1
25 anisometropia 10.2 PHOX2A CHN1
26 hypothalamic disease 10.2 PRL GH1
27 mechanical strabismus 10.2
28 ocular neuromyotonia 10.2
29 salpingitis isthmica nodosa 10.2 PRL KRT8
30 prostate stromal sarcoma 10.1 MYOG KRT8
31 prolactin producing pituitary tumor 10.1 PRL MGMT
32 combined hepatocellular carcinoma and cholangiocarcinoma 10.1 SALL4 AKT1
33 congenital ptosis 10.1 TUBB2B PHOX2A KIF21A CHN1
34 breast osteosarcoma 10.1 MYOG KRT8
35 uterus leiomyosarcoma 10.1 MYOG KRT8
36 endobronchial leiomyoma 10.1 PRTN3 MYOG
37 uterine corpus sarcoma 10.1 MYOG KRT8
38 orbital disease 10.1 PRTN3 PHOX2A KIF21A
39 accommodative esotropia 10.1 SALL4 ROBO3 PHOX2A CHN1
40 nelson syndrome 10.1 PRL MGMT
41 kearns-sayre syndrome 10.0
42 astigmatism 10.0
43 aneurysmal bone cysts 10.0
44 exanthem 10.0
45 ptosis 10.0
46 mumps 10.0
47 monocular esotropia 10.0
48 sphenoid sinusitis 10.0
49 intracranial aneurysm 10.0
50 q fever 10.0

Comorbidity relations with Partial Third-Nerve Palsy via Phenotypic Disease Network (PDN):


Diabetic Polyneuropathy Hypertension, Essential

Graphical network of the top 20 diseases related to Partial Third-Nerve Palsy:



Diseases related to Partial Third-Nerve Palsy

Symptoms & Phenotypes for Partial Third-Nerve Palsy

UMLS symptoms related to Partial Third-Nerve Palsy:


ophthalmoplegia; ophthalmoparesis; setting-sun eye phenomenon

MGI Mouse Phenotypes related to Partial Third-Nerve Palsy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.03 AGER AKT1 CHN1 IGF1 KIF21A MAP3K5
2 homeostasis/metabolism MP:0005376 9.97 AGER AKT1 CHN1 IGF1 KIF21A KRT8
3 nervous system MP:0003631 9.65 AKT1 CHN1 IGF1 KIF21A MGMT PHOX2A
4 respiratory system MP:0005388 9.17 AKT1 IGF1 MGMT MYOG PHOX2A ROBO3

Drugs & Therapeutics for Partial Third-Nerve Palsy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Retrospective Study to Investigate the Efficacy and Relative Factors of Ocular Acupuncture in Ocular Motor Nerve Palsy Patients Unknown status NCT03461809
2 A Randomized Trial of Ocular Electroacupuncture for Oculomotor Nerve Palsy Unknown status NCT03099447
3 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420

Search NIH Clinical Center for Partial Third-Nerve Palsy

Cochrane evidence based reviews: oculomotor nerve diseases

Genetic Tests for Partial Third-Nerve Palsy

Anatomical Context for Partial Third-Nerve Palsy

MalaCards organs/tissues related to Partial Third-Nerve Palsy:

40
Pituitary, Eye, Bone, Brain, Breast, Uterus, Prostate

Publications for Partial Third-Nerve Palsy

Articles related to Partial Third-Nerve Palsy:

(show top 50) (show all 55)
# Title Authors PMID Year
1
Neurovascular compression of the oculomotor nerve presenting with aberrant reinnervation. 61
33426366 2021
2
Use of endoscopic transorbital and endonasal approaches for 360° circumferential access to orbital tumors. 61
32977310 2020
3
Solitary Sign of Third Nerve Palsy in a Conscious Patient With Epidural Hemorrhage. 61
32983700 2020
4
Translamina Terminalis Approach to Laser-Assisted Resection of Thalamomesencephalic Cavernous Malformation. 61
32360676 2020
5
Pseudopartial Third Nerve Palsy as the Presenting Sign of Ocular Myasthenia Gravis. 61
32413010 2020
6
Partial third nerve palsy revealing cerebral cavernomatosis. 61
31230898 2019
7
Isolated third nerve palsy with pupillary involvement resulting from carotid-cavernous sinus fistula: A case report. 61
30732214 2019
8
Isolated bilateral partial third nerve palsy due to large midbrain tuberculoma. 61
31823946 2019
9
Congenital Ocular Neuromyotonia with Partial Third Nerve Palsy. 61
30806169 2019
10
Unique case of midbrain tuberculoma presenting as isolated inferior rectus palsy with nystagmus. 61
29582836 2018
11
Tuberculum Meningioma: Orbitopterional Approach. 61
29404259 2018
12
IgG4-related disease presenting as panuveitis without scleral involvement. 61
28243891 2017
13
A case report of rim enhancing lesion at the orbital apex. 61
28152321 2017
14
Acute hypertensive encephalopathy presenting with a partial third nerve palsy: image findings. 61
27932433 2016
15
[Neuro-ophthalmic emergencies]. 61
27639495 2016
16
Surgical management of third nerve palsy. 61
27433033 2016
17
Ophthalmic Features of Outpatient Children Diagnosed with Intracranial Space-Occupying Lesions by Ophthalmologists. 61
26180471 2015
18
Aneurysmal bone cyst with fibrous dysplasia resulting in partial third nerve palsy. 61
25863863 2015
19
Anterior petroclinoid fold fenestration: an adjunct to clipping of postero-laterally projecting posterior communicating aneurysms. 61
24817080 2014
20
Rare occurrence of a transient isolated unilateral partial third nerve palsy after angioplasty. 61
24326438 2013
21
Partial third nerve palsy and ocular neuromyotonia from displacement of posterior communicating artery detected by high-resolution MRI. 61
23912769 2013
22
Isolated, complete paralytic mydriasis secondary to herpes zoster ophthalmicus. 61
23487825 2013
23
Vision loss and partial third nerve palsy following contralateral peribulbar anesthesia. 61
23245365 2013
24
[Orbital cysticercosis mimicking a painful third nerve palsy]. 61
23122837 2012
25
[Unilateral isolated partial third nerve palsy and sphenoiditis in a child: A case report]. 61
22475536 2012
26
Improvement in the field of binocular single vision following bilateral phacoemulsification with toric intraocular lens implantation in a patient with a partial third nerve palsy. 61
21168083 2010
27
Partial third nerve palsy after Measles Mumps Rubella vaccination. 61
20831779 2010
28
Diplopia due to partial third nerve palsy -- two interesting images. 61
21114143 2010
29
Isolated unilateral ptosis and mydriasis from ventral midbrain infarction. 61
19390769 2009
30
Partial third nerve palsy involving the superior rectus and levator palpebrae muscles and distruption of central binocular vision fusion from brain stem infarction: a case report. 61
19807689 2009
31
The role of Botulinum toxin in management of acute traumatic third-nerve palsy. 61
18558505 2008
32
Nebulised ipratropium causing a unilateral fixed dilated pupil in the critically ill patient: a report of two cases. 61
16556105 2004
33
Ocular palsy following Le Fort 1 osteotomy: a case report. 61
14690665 2004
34
Transient third nerve palsy in a young patient with intracranial arteriovenous malformation. 61
12747657 2003
35
Pupil-sparing third nerve palsy with preoperative improvement from a posterior communicating artery aneurysm. 61
12176209 2002
36
Cavernous carotid aneurysms rarely cause subarachnoid hemorrhage or major neurologic morbidity. 61
17903849 2002
37
Strabismus surgery in congenital third nerve palsy. 61
11458298 2001
38
Partial third nerve palsy caused with chronic Q Fever. 61
10866498 1999
39
Pituitary apoplexy after spinal anaesthesia. 61
9924246 1998
40
Ocular neuromyotonia: three case reports with eye movement recordings. 61
9532530 1998
41
Pupil-involving third-nerve palsy and carotid stenosis: rapid recovery following endarterectomy. 61
9029079 1997
42
["Abducens neuromyotonia" with partial oculomotor paralysis]. 61
1331829 1992
43
Neurological complications following liver transplantation. 61
1514776 1992
44
Isolated pupil-sparing third-nerve palsy as the presenting sign of multiple sclerosis. 61
2357166 1990
45
Ptosis as the early manifestation of pituitary tumour. 61
2322519 1990
46
Pituitary adenoma presenting as painful intermittent third nerve palsy. 61
2759852 1989
47
Progressive hemifacial atrophy (Parry-Romberg disease). 61
3559850 1987
48
Isolated partial third nerve palsy following Le Fort I maxillary osteotomy in a patient with cleft lip and palate. 61
2941068 1986
49
Vertical diplopia. 61
3332419 1986
50
Pupillary sparing oculomotor palsy from acute subdural hematoma. 61
6721349 1984

Variations for Partial Third-Nerve Palsy

Expression for Partial Third-Nerve Palsy

Search GEO for disease gene expression data for Partial Third-Nerve Palsy.

Pathways for Partial Third-Nerve Palsy

Pathways related to Partial Third-Nerve Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.52 MAP3K5 CHN1 AKT1
2 11.18 MGMT IGF1 AKT1
3 10.61 IGF1 GH1 AKT1
4 10.41 MAP3K5 AKT1

GO Terms for Partial Third-Nerve Palsy

Cellular components related to Partial Third-Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 PRL GH1

Biological processes related to Partial Third-Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.4 IGF1 AKT1
2 myoblast differentiation GO:0045445 9.37 MYOG IGF1
3 positive regulation of glycogen biosynthetic process GO:0045725 9.32 IGF1 AKT1
4 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.26 PRL GH1
5 insulin-like growth factor receptor signaling pathway GO:0048009 9.16 IGF1 AKT1
6 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.96 IGF1 GH1
7 mammary gland epithelial cell differentiation GO:0060644 8.62 MGMT AKT1

Molecular functions related to Partial Third-Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 PRL IGF1 GH1
2 prolactin receptor binding GO:0005148 8.62 PRL GH1

Sources for Partial Third-Nerve Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....