MCID: PTL009
MIFTS: 40

Patella, Chondromalacia of

Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Patella, Chondromalacia of

MalaCards integrated aliases for Patella, Chondromalacia of:

Name: Patella, Chondromalacia of 57 37
Chondromalacia Patellae 12 44 15 32
Softening of Articular Cartilage of Patella 12
Familial Chondromalacia Patellae 58
Chondromalacia of Patella 12

Characteristics:

Orphanet epidemiological data:

58
familial chondromalacia patellae
Inheritance: Y-linked; Prevalence: <1/1000000 (Worldwide); Age of onset: Adolescent; Age of death: any age;

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
patella, chondromalacia of:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Rare bone diseases
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 12 DOID:13357
OMIM® 57 168900
ICD9CM 34 717.7
MeSH 44 D046789
SNOMED-CT 67 156521009
ICD10 32 M22.4
ICD10 via Orphanet 33 M22.4
Orphanet 58 ORPHA1428
MedGen 41 C0008475
SNOMED-CT via HPO 68 263681008
UMLS 70 C0008475

Summaries for Patella, Chondromalacia of

MalaCards based summary : Patella, Chondromalacia of, also known as chondromalacia patellae, is related to chondromalacia and acute mountain sickness. An important gene associated with Patella, Chondromalacia of is COMP (Cartilage Oligomeric Matrix Protein), and among its related pathways/superpathways are Neuroscience and Signaling by ERBB4. The drugs Methylene blue and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are abnormal patella morphology and Decreased viability

Wikipedia : 73 Chondromalacia patellae (also known as CMP) is an inflammation of the underside of the patella and... more...

More information from OMIM: 168900

Related Diseases for Patella, Chondromalacia of

Diseases related to Patella, Chondromalacia of via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 chondromalacia 32.4 IBSP COMP ACAN
2 acute mountain sickness 30.1 S100B ACE
3 bone disease 30.0 IBSP COMP COL2A1 ACAN
4 patellofemoral pain syndrome 10.4
5 osteoarthritis 10.4
6 platyspondylic lethal skeletal dysplasia, torrance type 10.2 COMP COL2A1
7 epiglottis neoplasm 10.2 PIK3CA CD79A
8 glomerular disease 10.1 CD79A ACE
9 epicondylitis 10.1 PRR4 ACAN
10 keratitis, hereditary 10.1
11 enthesopathy 10.1
12 muscular atrophy 10.1
13 hypermobile ehlers-danlos syndrome 10.1
14 trochlear dysplasia 10.1
15 overuse syndrome 10.1
16 rosette-forming glioneuronal tumor 10.1 S100B PIK3CA
17 subglottis benign neoplasm 10.0 CD79A CAGE1
18 hypochondrogenesis 10.0 COL2A1 ACAN
19 testicular torsion 10.0 CD79A ACE
20 intracranial vasospasm 10.0 S100B ACE
21 spondyloepiphyseal dysplasia congenita 10.0 COMP COL2A1
22 cartilage disease 10.0 COMP COL2A1 ACAN
23 cardiac tamponade 10.0 F8 ACE
24 osteochondrosis 10.0 COMP COL2A1 ACAN
25 achondrogenesis, type ii 10.0 COMP COL2A1 ACAN
26 achondrogenesis 10.0 COMP COL2A1 ACAN
27 spondyloepiphyseal dysplasia with congenital joint dislocations 10.0 COMP COL2A1 ACAN
28 pseudoachondroplasia 10.0 COMP COL2A1 ACAN
29 ischemic bone disease 10.0 IBSP COL2A1 ACAN
30 achondroplasia 10.0 COMP COL2A1 ACAN
31 multiple epiphyseal dysplasia 10.0 COMP COL2A1 ACAN
32 dental pulp necrosis 9.9 NT5E IBSP
33 synovitis 9.9 COMP COL2A1 ACAN
34 hypophosphatasia, childhood 9.9 IBSP ACE
35 odontogenic myxoma 9.9 S100B ACAN
36 hemarthrosis 9.9 F8 ACAN
37 bone inflammation disease 9.9 COMP COL2A1 ACAN
38 bone development disease 9.9 IBSP COMP COL2A1 ACAN
39 dental pulp disease 9.8 NT5E IBSP
40 calciphylaxis 9.8 NT5E CD79A
41 arthropathy 9.8 F8 COMP COL2A1 ACAN
42 malignant giant cell tumor of soft parts 9.7 S100B NT5E
43 brittle bone disorder 9.4 NT5E IBSP COMP COL2A1 ACAN
44 odontochondrodysplasia 9.4 NT5E IBSP COMP COL2A1 ACAN

Graphical network of the top 20 diseases related to Patella, Chondromalacia of:



Diseases related to Patella, Chondromalacia of

Symptoms & Phenotypes for Patella, Chondromalacia of

Human phenotypes related to Patella, Chondromalacia of:

31
# Description HPO Frequency HPO Source Accession
1 abnormal patella morphology 31 HP:0003045

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Limbs:
patellar pain
patellar chondromalacia

Clinical features from OMIM®:

168900 (Updated 05-Apr-2021)

GenomeRNAi Phenotypes related to Patella, Chondromalacia of according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.72 PIK3CA
2 Decreased viability GR00055-A-2 9.72 PIK3CA
3 Decreased viability GR00106-A-0 9.72 UBB
4 Decreased viability GR00221-A-1 9.72 EPHB3 PIK3CA
5 Decreased viability GR00221-A-2 9.72 PIK3CA
6 Decreased viability GR00221-A-4 9.72 EPHB3 PIK3CA
7 Decreased viability GR00240-S-1 9.72 TFG
8 Decreased viability GR00249-S 9.72 CD79A EPHB3 UBB
9 Decreased viability GR00342-S-1 9.72 EPHB3
10 Decreased viability GR00381-A-1 9.72 CD79A NT5E UBB
11 Decreased viability GR00381-A-3 9.72 CD79A
12 Decreased viability GR00386-A-1 9.72 CD79A F8 IBSP TFG UBB
13 Decreased viability GR00402-S-2 9.72 COMP PIK3CA UBB

Drugs & Therapeutics for Patella, Chondromalacia of

Drugs for Patella, Chondromalacia of (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational Phase 4 61-73-4
2
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
3
Lidocaine Approved, Vet_approved 137-58-6 3676
4
Povidone-iodine Approved 25655-41-8
5 Pharmaceutical Solutions
6 neurokinin A
7
Substance P 33507-63-0 44359816
8 Protective Agents
9 Immunologic Factors
10 Adjuvants, Immunologic
11 Hylan
12 Viscosupplements

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Injection Site Diversity Influences Sodium Hyaluronate Distribution and Its Clinical Results in Management of Chondromalacia Patellae and Knee Osteoarthritis: A Preliminary, Multi-central, Randomize-controlled Serial Trial Completed NCT03600571 Phase 4
2 Effectiveness of Neuroprolotherapy With Home Physical Therapy Against Isolated Physical Therapy for the Treatment of Patellar Chondromalacia Unknown status NCT03515720
3 Prevalence of Chondromalacia Patella Among Adolescent Dancers - Correlation Between Symptoms and Sonography Findings Unknown status NCT02606942
4 Effect of Pulsed Signal Therapy in Patella Chondromalacia. Randomized Prospective Trial. Completed NCT02012413
5 Temporal Activation of Core Muscles and Vasti in Isolated Patellofemoral Osteoarthritis During Stair-stepping Completed NCT04589702
6 Changes in Quadriceps Function Following Local or Distant Interventions in Individuals With Patellofemoral Pain Completed NCT01434966
7 Prospective, Randomized, Double Blind Evaluation of the Efficacy of a Single Dose of Synvisc-One® (6.0 cc) for the Treatment of Patellofemoral Chondromalacia Completed NCT01771952
8 Effect of Core Stability Exercise on Temporal Activation of Core Muscles and Vasti in Isolated Patellofemoral Osteoarthritis. Recruiting NCT04669834
9 The Effectiveness of Prolotherapy (%5 Dextros) in the Treatment of Patients With Chondromalacia Patella: a Randomized Controlled Trial Recruiting NCT04796103

Search NIH Clinical Center for Patella, Chondromalacia of

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Patella, Chondromalacia of cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Patella, Chondromalacia of:
JACC, cultured cartilage for chondral lesion
Embryonic/Adult Cultured Cells Related to Patella, Chondromalacia of:
Cultured cartilage (JACC) PMIDs: 19393556 10738867 16226641 12043781 16233853 19802670 10679677 11284883 16233778

Cochrane evidence based reviews: chondromalacia patellae

Genetic Tests for Patella, Chondromalacia of

Anatomical Context for Patella, Chondromalacia of

MalaCards organs/tissues related to Patella, Chondromalacia of:

40
Bone

Publications for Patella, Chondromalacia of

Articles related to Patella, Chondromalacia of:

(show top 50) (show all 279)
# Title Authors PMID Year
1
INHERITABLE CHONDROMALACIA OF THE PATELLA. 57
14083144 1963
2
Bone-cartilage mismatch in the medial tibial plateau: A MRI study. 61
33676321 2021
3
Vibroarthrographic Signal Spectral Features in 5-Class Knee Joint Classification. 61
32899440 2020
4
Relation of the chondromalatia patellae to proximal tibial anatomical parameters, assessed with MRI. 61
32324164 2020
5
Assessment of the relationship between patellar volume and chondromalacia patellae using knee magnetic resonance imaging. 61
32478301 2020
6
A novel clinical test for assessing patellar cartilage changes and its correlation with magnetic resonance imaging and arthroscopy. 61
29601214 2019
7
[Hyaluronate acid for treatment of chondromalacia patellae: a 52-week follow-up study]. 61
31340911 2019
8
WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of exposure to occupational ergonomic risk factors and of the effect of exposure to occupational ergonomic risk factors on osteoarthritis of hip or knee and selected other musculoskeletal diseases. 61
30583853 2019
9
Analysis of patellofemoral arthrokinematic motion quality in open and closed kinetic chains using vibroarthrography. 61
30704430 2019
10
Does the grading of chondromalacia patellae influence anterior knee pain following total knee arthroplasty without patellar resurfacing? 61
28986675 2018
11
Investigation of the Relationship between Anterior Knee Pain and Chondromalacia Patellae and Patellofemoral Malalignment. 61
29531488 2018
12
Analysis and multiclass classification of pathological knee joints using vibroarthrographic signals. 61
29249345 2018
13
Sagittal plane tilting deformity of the patellofemoral joint: a new concept in patients with chondromalacia patella. 61
27034088 2017
14
A new MRI grading system for chondromalacia patellae. 61
27329395 2017
15
Clinical effect of traditional Chinese spinal orthopedic manipulation in treatment of chondromalacia patellae. 61
29949332 2016
16
Joint Motion Quality in Chondromalacia Progression Assessed by Vibroacoustic Signal Analysis. 61
27060646 2016
17
Incidence and Risk Factors for Chronic Anterior Knee Pain. 61
26166427 2016
18
Patellofemoral pain. 61
26834209 2016
19
The association of patellofemoral joint morphology with chondromalacia patella: a quantitative MRI analysis. 61
24651059 2014
20
Correlation between subcutaneous knee fat thickness and chondromalacia patellae on magnetic resonance imaging of the knee. 61
22884229 2013
21
A novel biological approach to treat chondromalacia patellae. 61
23700485 2013
22
Change of patellar height with age and sex. 61
23936959 2012
23
The modified tibial tubercle osteotomy for anterior knee pain due to chondromalacia patellae in adults: A five-year prospective study. 61
23610687 2012
24
The role of autologous chondrocyte implantation in the treatment of symptomatic chondromalacia patellae. 61
22246591 2012
25
Anterior knee pain: the pitfalls of plica and chondromalacia patellae. 61
21699003 2011
26
Get a kick out of this: the spectrum of knee extensor mechanism injuries. 61
20966035 2011
27
Reliability of clinical findings and magnetic resonance imaging for the diagnosis of chondromalacia patellae. 61
20360517 2010
28
Knee joint examinations by magnetic resonance imaging: The correlation of pathology, age, and sex. 61
22624141 2010
29
MRI evaluation of anterior knee pain: predicting response to nonoperative treatment. 61
19381628 2009
30
The reliability and validity of assessing medio-lateral patellar position: a systematic review. 61
18824392 2009
31
Chondromalacia patellae treated by warming needle and rehabilitation training. 61
19663091 2009
32
Evaluation of magnetic resonance signal modification induced by hyaluronic acid therapy in chondromalacia patellae: a preliminary study. 61
19036227 2008
33
MRI quantitative morphologic analysis of patellofemoral region: lack of correlation with chondromalacia patellae at surgery. 61
17954655 2007
34
The relationship between patella position and length of the iliotibial band as assessed using Ober's test. 61
16867314 2006
35
In vivo study on the short-term effect of radiofrequency energy on chondromalacic patellar cartilage and its correlation with calcified cartilage pathology in an equine model. 61
16514662 2006
36
Large extrasynovial intracapsular ganglia of the knee: a report of 3 cases. 61
16325088 2005
37
Neglected femoral diaphyseal fracture. 61
15685058 2005
38
Imaging of patellofemoral disorders. 61
15208060 2004
39
Single photon emission computed tomography scanning in the diagnosis of knee pathology. 61
15237128 2004
40
A correlative study between prevalence of chondromalacia patellae and sports injury in 4068 students. 61
14642059 2003
41
Relation between isokinetic muscle strength and functional capacity in recreational athletes with chondromalacia patellae. 61
14665581 2003
42
The epidemiology of knee and ankle injuries on Macquarie Island. 61
14580818 2003
43
The accuracy of joint line tenderness by physical examination in the diagnosis of meniscal tears. 61
14551547 2003
44
MR arthrography in chondromalacia patellae diagnosis on a low-field open magnet system. 61
12727059 2003
45
Dynamics of muscle strength improvement during isokinetic rehabilitation of athletes with ACL rupture and chondromalacia patellae. 61
12629465 2003
46
Increased serum cartilage oligomeric matrix protein levels and decreased patellar bone mineral density in patients with chondromalacia patellae. 61
12379520 2002
47
[Anterior knee pain associated with sports and work]. 61
11831127 2001
48
The etiology of chondromalacia patellae. 1961. 61
11501822 2001
49
[Is autologous chondrocyte implantation a technology suitable for ambulatory health care?]. 61
11398625 2001
50
Ultrastructural findings after intraarticular application of hyaluronan in a canine model of arthropathy. 61
11052497 2000

Variations for Patella, Chondromalacia of

Expression for Patella, Chondromalacia of

Search GEO for disease gene expression data for Patella, Chondromalacia of.

Pathways for Patella, Chondromalacia of

Pathways related to Patella, Chondromalacia of according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.16 UBB S100B NT5E FMR1
2
Show member pathways
11.47 UBB S100B PIK3CA
3 11.31 COL2A1 CD79A ACAN
4 10.89 IBSP COMP ACAN
5 10.36 COMP COL2A1 ACAN

GO Terms for Patella, Chondromalacia of

Cellular components related to Patella, Chondromalacia of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 UBB TIMP4 S100B PRR4 IBSP F8
2 extracellular matrix GO:0031012 9.46 TIMP4 COMP COL2A1 ACAN
3 extracellular region GO:0005576 9.32 TIMP4 S100B PRR4 IBSP F8 EPHB3

Biological processes related to Patella, Chondromalacia of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.46 IBSP COMP COL2A1 ACAN
2 ossification GO:0001503 9.43 IBSP COMP COL2A1
3 cartilage condensation GO:0001502 9.37 COL2A1 ACAN
4 chondrocyte development GO:0002063 9.32 COMP ACAN
5 collagen fibril organization GO:0030199 9.13 COMP COL2A1 ACAN
6 central nervous system development GO:0007417 8.92 TIMP4 S100B COL2A1 ACAN

Molecular functions related to Patella, Chondromalacia of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 UBB TIMP4 TFG SLC24A5 S100B PRR4
2 extracellular matrix structural constituent GO:0005201 9.33 COMP COL2A1 ACAN
3 proteoglycan binding GO:0043394 8.62 COMP COL2A1

Sources for Patella, Chondromalacia of

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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