MCID: PTL009
MIFTS: 40

Patella, Chondromalacia of

Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Patella, Chondromalacia of

MalaCards integrated aliases for Patella, Chondromalacia of:

Name: Patella, Chondromalacia of 57 38
Chondromalacia Patellae 38 12 44 15
Softening of Articular Cartilage of Patella 12
Familial Chondromalacia Patellae 59
Chondromalacia of Patella 12

Characteristics:

Orphanet epidemiological data:

59
familial chondromalacia patellae
Inheritance: Y-linked; Prevalence: <1/1000000 (Worldwide); Age of onset: Adolescent; Age of death: any age;

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
patella, chondromalacia of:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 168900
Disease Ontology 12 DOID:13357
ICD10 33 M22.4
ICD9CM 35 717.7
MeSH 44 D046789
SNOMED-CT 68 36071006
Orphanet 59 ORPHA1428
ICD10 via Orphanet 34 M22.4
MedGen 42 C0008475
SNOMED-CT via HPO 69 263681008
UMLS 73 C0008475

Summaries for Patella, Chondromalacia of

MalaCards based summary : Patella, Chondromalacia of, also known as chondromalacia patellae, is related to chondromalacia and osteoarthritis. An important gene associated with Patella, Chondromalacia of is EGR3 (Early Growth Response 3), and among its related pathways/superpathways are ECM-receptor interaction and ECM proteoglycans. The drugs Hyaluronic acid and Methylene blue have been mentioned in the context of this disorder. Affiliated tissues include bone and testes, and related phenotypes are abnormality of the patella and Increased gamma-H2AX phosphorylation

Wikipedia : 76 Chondromalacia patellae (also known as CMP) is inflammation of the underside of the patella and... more...

Description from OMIM: 168900

Related Diseases for Patella, Chondromalacia of

Diseases related to Patella, Chondromalacia of via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 chondromalacia 30.5 COMP GSTO1 IBSP
2 osteoarthritis 10.3
3 patellofemoral pain syndrome 10.1
4 enthesopathy 10.1
5 bursitis 10.1
6 acute mountain sickness 10.1
7 cartilage disease 9.9 COMP GSTO1
8 aortic valve disease 2 9.8 ACE IBSP
9 connective tissue disease 9.7 ACE IBSP

Graphical network of the top 20 diseases related to Patella, Chondromalacia of:



Diseases related to Patella, Chondromalacia of

Symptoms & Phenotypes for Patella, Chondromalacia of

Symptoms via clinical synopsis from OMIM:

57
Limbs:
patellar pain
patellar chondromalacia


Clinical features from OMIM:

168900

Human phenotypes related to Patella, Chondromalacia of:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the patella 32 HP:0003045

GenomeRNAi Phenotypes related to Patella, Chondromalacia of according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 9.26 ACE COMP GSTO1 IL24
2 Increased Nanog expression GR00371-A-2 8.92 EGR3 IL24
3 Increased Nanog expression GR00371-A-4 8.92 IL24
4 Increased Nanog expression GR00371-A-5 8.92 IL24

MGI Mouse Phenotypes related to Patella, Chondromalacia of:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 ACE COMP EGR3 GSTO1 IL24

Drugs & Therapeutics for Patella, Chondromalacia of

Drugs for Patella, Chondromalacia of (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
2
Methylene blue Approved, Investigational Phase 4 61-73-4
3
Povidone-iodine Approved Not Applicable 25655-41-8
4
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
5
Substance P Investigational Not Applicable 33507-63-0 44359816
6 Immunologic Factors Not Applicable
7 Adjuvants, Immunologic Not Applicable
8 Hylan Not Applicable
9 Viscosupplements Not Applicable
10 Protective Agents Not Applicable
11
s 1 (combination) Not Applicable
12 Pharmaceutical Solutions Not Applicable
13 neurokinin A Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Injection Site Diversity Influences HA Distribution and Clinical Results in CP and KOA Completed NCT03600571 Phase 4
2 Prevalence of Chondromalacia Patella Among Adolescent Dancers - Correlation Between Symptoms and Sonography Findings Unknown status NCT02606942
3 Randomized Evaluation of the Efficacy of Synvisc-One® for the Treatment of Patellofemoral Chondromalacia Unknown status NCT01771952 Not Applicable
4 Effect of Pulsed Signal Therapy in Patella Chondromalacia Completed NCT02012413 Not Applicable
5 Changes in Quadriceps Function Following Local or Distant Interventions in Individuals With Patellofemoral Pain Completed NCT01434966 Not Applicable
6 Neuroprolotherapy With Physical Therapy for Treatment of Patellar Chondromalacia Not yet recruiting NCT03515720 Not Applicable

Search NIH Clinical Center for Patella, Chondromalacia of

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Patella, Chondromalacia of cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Patella, Chondromalacia of:
JACC�, cultured cartilage for chondral lesion
Embryonic/Adult Cultured Cells Related to Patella, Chondromalacia of:
Cultured cartilage (JACC�) PMIDs: 16233778 19393556 10738867 16226641 11284883 12043781 16233853 19802670 10679677

Cochrane evidence based reviews: chondromalacia patellae

Genetic Tests for Patella, Chondromalacia of

Anatomical Context for Patella, Chondromalacia of

MalaCards organs/tissues related to Patella, Chondromalacia of:

41
Bone, Testes

Publications for Patella, Chondromalacia of

Articles related to Patella, Chondromalacia of:

(show top 50) (show all 126)
# Title Authors Year
1
Investigation of the Relationship between Anterior Knee Pain and Chondromalacia Patellae and Patellofemoral Malalignment. ( 29531488 )
2018
2
Does the grading of chondromalacia patellae influence anterior knee pain following total knee arthroplasty without patellar resurfacing? ( 28986675 )
2017
3
Clinical effect of traditional Chinese spinal orthopedic manipulation in treatment of chondromalacia patellae. ( 29949332 )
2016
4
A new MRI grading system for chondromalacia patellae. ( 27329395 )
2016
5
A novel biological approach to treat chondromalacia patellae. ( 23700485 )
2013
6
Correlation between subcutaneous knee fat thickness and chondromalacia patellae on magnetic resonance imaging of the knee. ( 22884229 )
2013
7
The modified tibial tubercle osteotomy for anterior knee pain due to chondromalacia patellae in adults: A five-year prospective study. ( 23610687 )
2012
8
The role of autologous chondrocyte implantation in the treatment of symptomatic chondromalacia patellae. ( 22246591 )
2012
9
Anterior knee pain: the pitfalls of plica and chondromalacia patellae. ( 21699003 )
2011
10
Reliability of clinical findings and magnetic resonance imaging for the diagnosis of chondromalacia patellae. ( 20360517 )
2010
11
Chondromalacia patellae treated by warming needle and rehabilitation training. ( 19663091 )
2009
12
Evaluation of magnetic resonance signal modification induced by hyaluronic acid therapy in chondromalacia patellae: a preliminary study. ( 19036227 )
2008
13
MRI quantitative morphologic analysis of patellofemoral region: lack of correlation with chondromalacia patellae at surgery. ( 17954655 )
2007
14
A correlative study between prevalence of chondromalacia patellae and sports injury in 4068 students. ( 14642059 )
2003
15
MR arthrography in chondromalacia patellae diagnosis on a low-field open magnet system. ( 12727059 )
2003
16
Dynamics of muscle strength improvement during isokinetic rehabilitation of athletes with ACL rupture and chondromalacia patellae. ( 12629465 )
2003
17
Relation between isokinetic muscle strength and functional capacity in recreational athletes with chondromalacia patellae. ( 14665581 )
2003
18
Increased serum cartilage oligomeric matrix protein levels and decreased patellar bone mineral density in patients with chondromalacia patellae. ( 12379520 )
2002
19
The etiology of chondromalacia patellae. 1961. ( 11501822 )
2001
20
Images. Patellofemoral pain syndrome (chondromalacia patellae) and mild acute mountain sickness. ( 10731905 )
2000
21
Joint hypermobility in patients with chondromalacia patellae. ( 9448595 )
1997
22
A report of 76 cases of chondromalacia patellae treated with an ointment. ( 10437243 )
1997
23
The influence of subchondral vascularisation on chondromalacia patellae. ( 8905103 )
1996
24
Chondromalacia patellae: an in vitro study. Comparison of MR criteria with histologic and macroscopic findings. ( 8958618 )
1996
25
Decreased torque and electromyographic activity in the extensor thigh muscles in chondromalacia patellae. ( 7713630 )
1995
26
Chondromalacia patellae: fat-suppressed MR imaging. ( 7972759 )
1994
27
Comparison of axial T1 spin-echo and T1 fat-saturation magnetic resonance imaging techniques in the diagnosis of chondromalacia patellae. ( 7885725 )
1994
28
Pinhole scintigraphic sign of chondromalacia patellae in older subjects: a prospective assessment with differential diagnosis. ( 8176471 )
1994
29
Detection and staging of chondromalacia patellae: relative efficacies of conventional MR imaging, MR arthrography, and CT arthrography. ( 8079858 )
1994
30
Lateral release in chondromalacia patellae using clinical, radiologic, electromyographic, and muscle force testing evaluation. ( 7944919 )
1994
31
Cartilage degeneration in the human patellae and its relationship to the mineralisation of the underlying bone: a key to the understanding of chondromalacia patellae and femoropatellar arthrosis? ( 8128335 )
1993
32
Synovial plicae and chondromalacia patellae: correlation of results of CT arthrography with results of arthroscopy. ( 8430194 )
1993
33
Structural and in vivo mechanical characterization of canine patellar cartilage: a closed chondromalacia patellae model. ( 8512885 )
1993
34
Chondromalacia patellae: diagnosis with MR imaging. ( 1727333 )
1992
35
Long-term results for the McKeever patellar resurfacing prosthesis used as a salvage procedure for severe chondromalacia patellae. ( 1600657 )
1992
36
Chondromalacia patellae. ( 1727334 )
1992
37
Historical perspectives of chondromalacia patellae. ( 1408036 )
1992
38
Changes in patellofemoral compressive force after anterior or anteromedial displacement of tibial tuberosity for chondromalacia patellae. ( 2019042 )
1991
39
Thermography in the detection and follow up of chondromalacia patellae. ( 1768161 )
1991
40
Low level laser treatment of chondromalacia patellae. ( 1809720 )
1991
41
Arthroscopic treatment of posttraumatic chondromalacia patellae. ( 2352907 )
1990
42
Effect of glycosaminoglycan polysulfate on chondromalacia patellae. A placebo-controlled 1-year study. ( 2239170 )
1990
43
The natural history of chondromalacia patellae. A 12-year follow-up. ( 2239198 )
1990
44
Chondromalacia patellae. ( 2926288 )
1989
45
Anterior Knee Pain (Chondromalacia Patellae). ( 27448003 )
1989
46
Treatment of chondromalacia patellae by lateral retinacular release of the patella. ( 3409570 )
1988
47
Chondromalacia patellae. ( 3392476 )
1988
48
The effect of lateral retinacular release in idiopathic chondromalacia patellae. ( 3408317 )
1988
49
Contact pressures in chondromalacia patellae and the effects of capsular reconstructive procedures. ( 3379503 )
1988
50
Chondromalacia patellae: assessment with MR imaging. ( 3615877 )
1987

Variations for Patella, Chondromalacia of

Expression for Patella, Chondromalacia of

Search GEO for disease gene expression data for Patella, Chondromalacia of.

Pathways for Patella, Chondromalacia of

Pathways related to Patella, Chondromalacia of according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 COMP IBSP
2 10.38 COMP IBSP

GO Terms for Patella, Chondromalacia of

Cellular components related to Patella, Chondromalacia of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 ACE COMP IBSP IL24
2 extracellular space GO:0005615 8.92 ACE COMP IBSP IL24

Biological processes related to Patella, Chondromalacia of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 8.96 COMP IBSP
2 cellular response to growth factor stimulus GO:0071363 8.62 EGR3 IBSP

Sources for Patella, Chondromalacia of

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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