MCID: PTL002
MIFTS: 29

Patellofemoral Pain Syndrome

Categories: Bone diseases

Aliases & Classifications for Patellofemoral Pain Syndrome

MalaCards integrated aliases for Patellofemoral Pain Syndrome:

Name: Patellofemoral Pain Syndrome 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14284
MeSH 44 D046788
UMLS 73 C0877149

Summaries for Patellofemoral Pain Syndrome

MalaCards based summary : Patellofemoral Pain Syndrome is related to paine syndrome and patella, chondromalacia of, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Patellofemoral Pain Syndrome is PRF1 (Perforin 1). The drugs Acetaminophen and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include bone and testes, and related phenotype is Upregulation of RLR pathway after Sendai virus (SeV) infection.

Wikipedia : 76 Patellofemoral pain syndrome (PFPS), also known as runner\'s knee, is a condition characterized by knee... more...

Related Diseases for Patellofemoral Pain Syndrome

Diseases related to Patellofemoral Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 paine syndrome 11.1
2 patella, chondromalacia of 9.8
3 chondromalacia 9.8
4 conjunctivitis 9.8
5 acute mountain sickness 9.8

Graphical network of the top 20 diseases related to Patellofemoral Pain Syndrome:



Diseases related to Patellofemoral Pain Syndrome

Symptoms & Phenotypes for Patellofemoral Pain Syndrome

UMLS symptoms related to Patellofemoral Pain Syndrome:


arthralgia, metatarsalgia

GenomeRNAi Phenotypes related to Patellofemoral Pain Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Upregulation of RLR pathway after Sendai virus (SeV) infection GR00302-A 8.62 LARS KCNK6

Drugs & Therapeutics for Patellofemoral Pain Syndrome

Drugs for Patellofemoral Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2 Analgesics Phase 4,Not Applicable
3 Analgesics, Non-Narcotic Phase 4
4 Antipyretics Phase 4
5 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
6
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
7
Acetylcholine Approved Phase 3 51-84-3 187
8
Imidacloprid Vet_approved Phase 3 105827-78-9 86418
9 abobotulinumtoxinA Phase 3
10 Botulinum Toxins Phase 3
11 Botulinum Toxins, Type A Phase 3
12 Cholinergic Agents Phase 3
13 Neuromuscular Agents Phase 3
14 Neurotransmitter Agents Phase 3
15 onabotulinumtoxinA Phase 3
16
Hyaluronic acid Approved, Vet_approved Phase 2,Not Applicable 9004-61-9 53477741
17 Adjuvants, Immunologic Phase 2,Not Applicable
18 Hylan Phase 2,Not Applicable
19 Protective Agents Phase 2,Not Applicable
20 Viscosupplements Phase 2,Not Applicable
21
Povidone-iodine Approved Not Applicable 25655-41-8
22
Menthol Approved Not Applicable 2216-51-5 16666
23
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
24
Oxymetazoline Approved, Investigational Not Applicable 1491-59-4 4636
25
Phenylephrine Approved Not Applicable 59-42-7 6041
26
Ethanol Approved Not Applicable 64-17-5 702
27
Sulfamethazine Approved, Investigational, Vet_approved Not Applicable 57-68-1 5327
28
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
29 tannic acid Approved, Nutraceutical Not Applicable
30
s 1 (combination) Not Applicable
31 Antipruritics Not Applicable
32 Dermatologic Agents Not Applicable
33 Anesthetics
34 Astragalus Nutraceutical Not Applicable

Interventional clinical trials:

(show top 50) (show all 86)
# Name Status NCT ID Phase Drugs
1 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
2 Diacutaneous Fibrolysis and Patellofemoral Pain Syndrome Completed NCT02379364 Phase 3
3 A Clinical Study in the Use of Orthotics in Treating Pain in the Front of the Knee Completed NCT00118521 Phase 3
4 Comparing the Outcome of Electrical Stimulation and Physical Therapy in Patellofemoral Pain Syndrome Recruiting NCT03184545 Phase 3
5 Botox for Non-surgical Lateral Release in Patellofemoral Pain Terminated NCT00496964 Phase 3 Botulinum toxin A + exercise;Placebo
6 Comparison of The Clinical Effects Between Different Physical Therapy Tools in Patellofemoral Pain Patients Unknown status NCT00451347 Phase 1, Phase 2
7 Treatment for Patellofemoral Pain Syndrome Using Footwear Completed NCT01332110 Phase 1, Phase 2
8 Comparison of Two Protocols for Patellofemoral Pain Syndrome Completed NCT01691170 Phase 1, Phase 2
9 Assessing Foot Injuries in Infantry Recruits Wearing Different Boots Completed NCT02810002 Phase 1, Phase 2
10 Intra-articular Hyaluronic Acid Injection for Therapy-resistant Patellofemoral Pain Syndrome Recruiting NCT02613247 Phase 2
11 Comparisons of Mechanical Properties of Tendon Structures Unknown status NCT00451087 Phase 1
12 Effect of Hip Adduction Combination With Knee Extension Exercise on Morphology of Quadriceps Muscles, Pain and Functional Outcomes in Patients With PFPS Unknown status NCT00166777 Phase 1
13 Neural Mechanisms of Muscle Control in Individuals With Knee Pain Not yet recruiting NCT02854774 Phase 1
14 Hip Strengthening Versus Quadriceps Based Training for Patellofemoral Pain Syndrome Unknown status NCT02114294 Not Applicable
15 Foot Orthoses in Patellofemoral Pain Syndrome: a Prospective Randomized Study of Morpho-specific Versus Placebo Orthoses Unknown status NCT02250144 Not Applicable
16 Selective Neuromuscular Electrical Stimulation on VMO Unknown status NCT02548988 Not Applicable
17 Morphology of the VMO in Patients With PFPS and Healthy Young Adults--A Sonographic Study Unknown status NCT00173147
18 The Role of Quadriceps Contraction in Patellar Repositioning - a Computed Tomography Study Unknown status NCT00760136
19 Effects of Kinesio Taping in Patellofemoral Pain Unknown status NCT02827084 Not Applicable
20 The Effect of Muscle Strengthening Associated With Neuromuscular Stimulus in Patients With Patellofemoral Pain During Negotiating Stairs Unknown status NCT02591680 Not Applicable
21 Prevention of Injuries by an Exercise Program – a RCT Unknown status NCT00348647 Not Applicable
22 Randomized Evaluation of the Efficacy of Synvisc-One® for the Treatment of Patellofemoral Chondromalacia Unknown status NCT01771952 Not Applicable
23 Evaluation of a Treatment Algorithm for Patients With Patellofemoral Pain Syndrome Completed NCT02461095 Not Applicable
24 McConnell Patellar Taping in Static and Dynamic Postural Control of Women With Patellofemoral Pain Syndrome Completed NCT02841384 Not Applicable
25 Comparison of Effects of Mobilization With Movement and Kinesiotaping in Patellofemoral Pain Syndrome Completed NCT02707679 Not Applicable
26 Correlation Between the Amplitude of Ankle Dorsiflexion and Occurrence of Patellofemoral Pain Syndrome Completed NCT03213015 Not Applicable
27 Efficiency of Patellar Taping in Treatment of Patellofemoral Pain Syndrome Completed NCT01504100
28 Comparison Study of Two Chiropractic Treatment Protocols for Knee Pain Due to Patellofemoral Pain Syndrome Completed NCT00401050 Not Applicable
29 Dosage-dependence of Graded Exercise Therapy in Patients With Patellofemoral Pain Syndrome. Completed NCT01290705 Not Applicable
30 Early Intervention for Adolescents With Patellofemoral Pain Syndrome Completed NCT01438762 Not Applicable
31 Activation of Hip Muscles in Runners With Patellofemoral Syndrome Completed NCT02837289 Not Applicable
32 The Evaluation of a Novel Treatment Algorithm for Patients With Patellofemoral Syndrome Completed NCT01767246 Not Applicable
33 Manual Therapy and Dry Needling in Patellofemoral Syndrome Completed NCT02514005 Not Applicable
34 Effect of Lower Back Treatment in People With Patellofemoral Pain Syndrome. Completed NCT01975311 Not Applicable
35 Kinematics of Lower Limb, Pain and Function of the Women With Patellofemoral Pain Syndrome Completed NCT01804608 Not Applicable
36 Effects of Lumbopelvic Manipulation on Hip and Knee Neuromuscular Activity Completed NCT01637480 Not Applicable
37 Effectiveness Trial for Evaluating IAHA for PFPS Completed NCT01811654 Not Applicable
38 Patellar Taping on Proprioceptive Exercises in Young Women With Patellofemoral Pain Syndrome Completed NCT02322515 Not Applicable
39 Comparing Rehabilitation Programs for Patellofemoral Pain Syndrome Completed NCT00445224 Not Applicable
40 Effects of Hip Abductor and External Rotator Strength Training in Patients With Patellofemoral Pain Syndrome Completed NCT00736736 Not Applicable
41 The Effect of Kinesio Taping® on Motor Control in Patients With Patellofemoral Pain Syndrome Completed NCT03117205 Not Applicable
42 The Effects of Dry Needling & Kinesio Tape on Anterior Knee Pain Completed NCT02118246 Not Applicable
43 The Effects and Predictors of Patella Taping in the Treatment of Patellafemoral Pain Syndrome Completed NCT01727596 Not Applicable
44 Investigation of Muscle Activity Pattern of Gluteus Medius and Tensor Fascia Lata in Patients With PFPS Completed NCT00451438
45 Conventional Home Exercise Programs Versus Electronic Home Exercise Versus Artificial Intelligence "Virtual Therapy" for Anterior Knee Pain Completed NCT01696162 Not Applicable
46 Vasti Control of Patellofemoral Kinematics in Asymptomatic Volunteer Completed NCT00978003
47 Utilizing the Trunk as a Proximal Lever to Strengthen the Hip Musculature and Alter Lower Extremity Function Completed NCT03285464 Not Applicable
48 Effects of Hip and Knee Exercises on Knee Pain in Young Adult Females With Long-standing Patellofemoral Pain Completed NCT03054701 Not Applicable
49 The Movement Control Training Associated With Conventional Physical Therapy is More Effective Than Conventional Physical Therapy Alone in Pain and Functional Performance? Completed NCT02624245 Not Applicable
50 Running Study for Runners With Chronic Knee Pain Completed NCT02567123 Not Applicable

Search NIH Clinical Center for Patellofemoral Pain Syndrome

Cochrane evidence based reviews: patellofemoral pain syndrome

Genetic Tests for Patellofemoral Pain Syndrome

Anatomical Context for Patellofemoral Pain Syndrome

MalaCards organs/tissues related to Patellofemoral Pain Syndrome:

41
Bone, Testes

Publications for Patellofemoral Pain Syndrome

Articles related to Patellofemoral Pain Syndrome:

(show top 50) (show all 353)
# Title Authors Year
1
Effects of vision and cognitive load on static postural control in subjects with and without patellofemoral pain syndrome. ( 29120261 )
2018
2
The effect of patellar taping on lower extremity running kinematics in individuals with patellofemoral pain syndrome. ( 29601217 )
2018
3
The effect of aroma stimulation during isotonic exercise on the rating of perceived exertion and blood fatigue factors of athletes with patellofemoral pain syndrome. ( 29545683 )
2018
4
The Effect of Diacutaneous Fibrolysis on Patellar Position Measured Using Ultrasound Scanning in Patellofemoral Pain Syndrome Patients. ( 29651911 )
2018
5
Effect of squatting velocity on hip muscle latency in women with patellofemoral pain syndrome. ( 29581655 )
2018
6
Effects of patellar taping on knee pain, functional disability, and patellar alignments in patients with patellofemoral pain syndrome: A randomized clinical trial. ( 29861256 )
2018
7
Effectiveness of conservative treatment for patellofemoral pain syndrome: A systematic review and meta-analysis. ( 29392329 )
2018
8
Preferential strengthening of VMO muscle during selected biomechanical rehabilitative exercises of automotive workers with patellofemoral pain syndrome. ( 29843298 )
2018
9
Current clinical, radiological and treatment perspectives of patellofemoral pain syndrome. ( 29303366 )
2018
10
Carryover effect of hip and knee exercises program on functional performance in individuals with patellofemoral pain syndrome. ( 28878459 )
2017
11
Effectiveness of Manual Therapy Combined With Physical Therapy in Treatment of Patellofemoral Pain Syndrome: Systematic Review. ( 28559754 )
2017
12
Patellofemoral pain syndrome in female athletes: A review of diagnoses, etiology and treatment options. ( 29564075 )
2017
13
Systematic Review of the Effect of Taping Techniques on Patellofemoral Pain Syndrome. ( 28617653 )
2017
14
Neuromuscular electrical stimulation (NMES) for patellofemoral pain syndrome. ( 29231243 )
2017
15
Patellar bracing affects sEMG activity of leg and thigh muscles during stance phase in patellofemoral pain syndrome. ( 28697399 )
2017
16
Squatting Re-education With Lumbo-Pelvic-Thigh Muscle Cocontraction Improves Functional Performance in Patellofemoral Pain Syndrome: A Case Presentation. ( 29133185 )
2017
17
Effects of Kinesio Taping<sup>Ar</sup>on knee function and pain in athletes with patellofemoral pain syndrome. ( 29037636 )
2017
18
Comparison of ischemic compression and lumbopelvic manipulation as trigger point therapy for patellofemoral pain syndrome in young adults: A double-blind randomized clinical trial. ( 28750964 )
2017
19
The immediate effect of lumbopelvic manipulation on EMG of vasti and gluteus medius in athletes with patellofemoral pain syndrome: A randomized controlled trial. ( 26995778 )
2016
20
Core Neuromuscular Training; a Physical Activity Intervention for Individuals with Patellofemoral Pain Syndrome: 3294 Board #359 June 3, 3: 30 PM - 5: 00 PM. ( 27361863 )
2016
21
The validity and reliability of the Thai version of the Kujala score for patients with patellofemoral pain syndrome. ( 26729626 )
2016
22
Short-term effects of kinesio tape on joint position sense, isokinetic measurements, and clinical parameters in patellofemoral pain syndrome. ( 27512259 )
2016
23
Greek cultural adaption and validation of the Kujala anterior knee pain scale in patients with patellofemoral pain syndrome. ( 27049481 )
2016
24
Is there a role of pulsed electromagnetic fields in management of patellofemoral pain syndrome? Randomized controlled study at one year follow-up. ( 26756278 )
2016
25
The effect of hip and knee exercises on pain, function, and strength in patientswith patellofemoral pain syndrome: a randomized controlled trial. ( 27511483 )
2016
26
Mcconnell's patellar taping does not alter knee and hip muscle activation differences during proprioceptive exercises: A randomized placebo-controlled trial in women with patellofemoral pain syndrome. ( 27693990 )
2016
27
TIBIOFEMORAL JOINT MOBILIZATION IN THE SUCCESSFUL MANAGEMENT OF PATELLOFEMORAL PAIN SYNDROME: A CASE REPORT. ( 27274430 )
2016
28
Kinematic and electromyographic analysis in patients with patellofemoral pain syndrome during single leg triple hop test. ( 27470227 )
2016
29
Effectiveness of core muscle strengthening for improving pain and dynamic balance among female patients with patellofemoral pain syndrome. ( 27313363 )
2016
30
Long term effect of selective muscle strengthening in athletes with patellofemoral pain syndrome. ( 27104322 )
2016
31
The Effect of Patellofemoral Pain Syndrome on Gait Parameters: A Literature Review. ( 27847840 )
2016
32
Short Arc Training Effects On Knee Strength, Pain, Functional Performance With Patellofemoral Pain Syndrome Patients: 1619 Board #272 June 2, 8: 00 AM - 9: 30 AM. ( 27360538 )
2016
33
Comparative evaluation of ambulation patterns and isokinetic muscle strength for the application of rehabilitation exercise in patients with patellofemoral pain syndrome. ( 28174434 )
2016
34
Evaluating the potential synergistic benefit of a realignment brace on patients receiving exercise therapy for patellofemoral pain syndrome: a randomized clinical trial. ( 27146819 )
2016
35
Effectiveness of hip muscle strengthening in patellofemoral pain syndrome patients: a systematic review. ( 26039034 )
2015
36
Vastus medialis oblique and vastus lateralis activity during a double-leg semisquat with or without hip adduction in patients with patellofemoral pain syndrome. ( 26459411 )
2015
37
Study protocol: a randomised controlled trial comparing the long term effects of isolated hip strengthening, quadriceps-based training and free physical activity for patellofemoral pain syndrome (anterior knee pain). ( 25879452 )
2015
38
&amp;quot;Measurement properties of patient-reported outcome measures (PROMS) in patellofemoral pain syndrome: A systematic review&amp;quot;. Green etA al. (in press corrected proof). ( 25660820 )
2015
39
Muscle Activation of Vastus Medialis Oblique and Vastus Lateralis in Sling-Based Exercises in Patients with Patellofemoral Pain Syndrome: A Cross-Over Study. ( 26504480 )
2015
40
Reply to Selfe (2014) letter to the editor on: Measurement properties of patient-reported outcome measures (PROMS) in patellofemoral pain syndrome: A systematic review. ( 25487345 )
2015
41
Exercise for treating patellofemoral pain syndrome. An abridged version of Cochrane Systematic Review. ( 26158920 )
2015
42
The Effects of a Multimodal Rehabilitation Program on Symptoms and Ground Reaction Forces in Runners With Patellofemoral Pain Syndrome. ( 25760965 )
2015
43
The relationship between quadriceps strength and joint position sense, functional outcome and painful activities in patellofemoral pain syndrome. ( 25869907 )
2015
44
Effectiveness of therapeutic physical exercise in the treatment of patellofemoral pain syndrome: a systematic review. ( 26311988 )
2015
45
Lower limb control and strength in runners with and without patellofemoral pain syndrome. ( 25800001 )
2015
46
Isokinetic profile in female athletes with and without patellofemoral pain syndrome after anterior cruciate ligament reconstruction. ( 26274876 )
2015
47
WITHDRAWN: Exercise therapy for patellofemoral pain syndrome. ( 25612084 )
2015
48
Predictors for identifying patients with patellofemoral pain syndrome responding to femoral nerve mobilization. ( 25576086 )
2015
49
Intra- and Inter-session Reliability of Static and Dynamic Postural Control in Participants with and without Patellofemoral Pain Syndrome. ( 26839452 )
2015
50
The effect of postural stabilization exercises on pain and function in females with patellofemoral pain syndrome. ( 26012938 )
2015

Variations for Patellofemoral Pain Syndrome

Expression for Patellofemoral Pain Syndrome

Search GEO for disease gene expression data for Patellofemoral Pain Syndrome.

Pathways for Patellofemoral Pain Syndrome

GO Terms for Patellofemoral Pain Syndrome

Biological processes related to Patellofemoral Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular defense response GO:0006968 8.62 LY96 PRF1

Sources for Patellofemoral Pain Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
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28 GO
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33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
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44 MeSH
45 MESH via Orphanet
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54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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