MCID: PTL002
MIFTS: 30

Patellofemoral Pain Syndrome

Categories: Bone diseases

Aliases & Classifications for Patellofemoral Pain Syndrome

MalaCards integrated aliases for Patellofemoral Pain Syndrome:

Name: Patellofemoral Pain Syndrome 12 44 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:14284
MeSH 44 D046788
UMLS 72 C0877149

Summaries for Patellofemoral Pain Syndrome

MalaCards based summary : Patellofemoral Pain Syndrome is related to chondromalacia and patella, chondromalacia of, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Patellofemoral Pain Syndrome is ANKLE1 (Ankyrin Repeat And LEM Domain Containing 1), and among its related pathways/superpathways is Immune response IFN alpha/beta signaling pathway. The drugs Acetaminophen and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and heart.

Wikipedia : 75 Patellofemoral pain syndrome (PFPS), also known as runner's knee, is knee pain as a result of problems... more...

Related Diseases for Patellofemoral Pain Syndrome

Diseases related to Patellofemoral Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 chondromalacia 10.4
2 patella, chondromalacia of 10.3
3 tendinitis 10.2
4 frozen shoulder 10.2
5 bursitis 10.2
6 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
7 body mass index quantitative trait locus 1 10.1
8 leukemia, acute lymphoblastic 3 10.0
9 tendinopathy 10.0
10 alexithymia 10.0
11 plica syndrome 10.0
12 arthropathy 10.0
13 osgood-schlatter's disease 10.0
14 osteochondrosis 10.0
15 osteochondritis dissecans 10.0
16 acute mountain sickness 10.0
17 bunion 10.0
18 chronic pain 10.0
19 dysautonomia 10.0
20 overuse syndrome 10.0

Graphical network of the top 20 diseases related to Patellofemoral Pain Syndrome:



Diseases related to Patellofemoral Pain Syndrome

Symptoms & Phenotypes for Patellofemoral Pain Syndrome

UMLS symptoms related to Patellofemoral Pain Syndrome:


arthralgia, metatarsalgia

Drugs & Therapeutics for Patellofemoral Pain Syndrome

Drugs for Patellofemoral Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2 Peripheral Nervous System Agents Phase 4
3 Analgesics Phase 4
4 Analgesics, Non-Narcotic Phase 4
5 Antipyretics Phase 4
6
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
7
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
8
Imidacloprid Vet_approved Phase 3 105827-78-9 86418
9 abobotulinumtoxinA Phase 3
10 Neurotransmitter Agents Phase 3
11 Neuromuscular Agents Phase 3
12 Cholinergic Agents Phase 3
13 Acetylcholine Release Inhibitors Phase 3
14 Botulinum Toxins Phase 3
15 Botulinum Toxins, Type A Phase 3
16 Hylan Phase 2
17
Povidone-iodine Approved 25655-41-8
18
Sulfamethazine Approved, Investigational, Vet_approved 57-68-1 5327
19
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
20
tannic acid Approved 1401-55-4
21
Oxymetazoline Approved, Investigational 1491-59-4 4636
22
Phenylephrine Approved 59-42-7 6041
23
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
24
Ethanol Approved 64-17-5 702
25
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
26 Adjuvants, Immunologic
27 Immunologic Factors
28 Protective Agents
29 Viscosupplements
30
s 1 (combination)
31 Astragalus
32 Anesthetics

Interventional clinical trials:

(show top 50) (show all 105)
# Name Status NCT ID Phase Drugs
1 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
2 Effectiveness of Diacutaneous Fibrolysis Technique on Pain, Range of Motion, Strength and Function in Patients With Patellofemoral Pain Syndrome Completed NCT02379364 Phase 3
3 Foot Orthotics in the Treatment of Patellofemoral Pain Syndrome: A Randomised Clinical Trial in Primary Care Completed NCT00118521 Phase 3
4 A Prospective Randomized Study Comparing the Outcome of Electrical Stimulation of Vastus Medialis Obliquus Muscle and Physical Therapy vs Only Physical Therapy But no Electrical Stimulation in Patients With Patellofemoral Pain Syndrome Recruiting NCT03184545 Phase 3
5 Botox for Non-surgical Lateral Release in Patellofemoral Pain Terminated NCT00496964 Phase 3 Botulinum toxin A + exercise;Placebo
6 Comparison of The Clinical Effects Between Different Physical Therapy Tools in Patellofemoral Pain Patients Unknown status NCT00451347 Phase 1, Phase 2
7 Intra-articular Hyaluronic Acid Injection for Therapy-resistant Patellofemoral Pain Syndrome: an Open-label, Randomized, Delayed-start Clinical Trial Unknown status NCT02613247 Phase 2
8 Quadriceps Femoris Strengthening Versus Hamstring Stretching for Patellofemoral Pain Syndrome: A Randomized Clinical Trial. Completed NCT01691170 Phase 1, Phase 2
9 Treatment for Patellofemoral Pain Syndrome Using Knee Abduction Moment-Reducing Footwear Completed NCT01332110 Phase 1, Phase 2
10 Assessing Foot Injuries in Infantry Recruits Wearing Different Boots, a Prospective Randomized Study Completed NCT02810002 Phase 1, Phase 2
11 Effect of Hip Adduction Combination With Knee Extension Exercise on Morphology of Quadriceps Muscles, Pain and Functional Outcomes in Patients With PFPS Unknown status NCT00166777 Phase 1
12 Phase 1 Study: Comparison of Electromechanical Delay Phase 2 Study: Research in Viscoelasticity of Tendon Structures Phase 3 Study: Effects of Exercise Training in the Mechanical Properties Unknown status NCT00451087 Phase 1
13 Neural Mechanisms of Muscle Control in Individuals With Knee Pain Suspended NCT02854774 Phase 1
14 Immediate Effect of Selective Neuromuscular Electrical Stimulation of Vastus Medialis Obliquus in Women With Patellofemoral Pain Syndrome Unknown status NCT02548988
15 The Effects of a Trunk Strengthening Program on Anterior Knee Pain in an Adolescent Athletic Population: a Randomized Clinical Trial Unknown status NCT02123602
16 The Effect of Muscle Strengthening Associated With Neuromuscular Stimulus in Patients With Patellofemoral Pain During Negotiating Stairs: A Randomized Controlled Trial Unknown status NCT02591680
17 Foot Orthoses in Patellofemoral Pain Syndrome: a Prospective Randomized Study of Morpho-specific Versus Placebo Orthoses Unknown status NCT02250144
18 The Role of Quadriceps Contraction in Patellar Repositioning-a Computed Tomography Study Unknown status NCT00760136
19 The Effects of Foot Exercises on Pain, Biomechanical Characteristics and Functionality of Lower Extremity in Patients With Patellofemoral Pain Unknown status NCT03099512
20 Morphology of the Vastus Medialis Obliquus in Patients With Patellofemoral Pain Syndrome and Healthy Young Adults --A Sonographic Study Unknown status NCT00173147
21 Effects of Kinesio Taping in Painful and Neuromuscular Performance of Patients With Patellofemoral Pain Unknown status NCT02827084
22 Can Lower Extremity Overuse Injuries Be Prevented by an Exercise Program Aiming at Muscular Strength, Flexibility and Coordination – a RCT Unknown status NCT00348647
23 The Effects of Protonics Knee Brace Versus Hamstring Resisted Exercise on Individuals With Patellofemoral Pain Syndrome Unknown status NCT03042559
24 Effect of Two Strengthening Protocols for Lower Limbs in Patients With Patellofemoral Pain: Randomized Clinical Trial Unknown status NCT03163290
25 Prospective, Randomized, Double Blind Evaluation of the Efficacy of a Single Dose of Synvisc-One® (6.0 cc) for the Treatment of Patellofemoral Chondromalacia Unknown status NCT01771952
26 Kinematics of Lower Limb, Pain and Function of the Women With Patellofemoral Pain Syndrome Who Underwent Two Types Treatment: Randomized Clinical Trial Completed NCT01804608
27 Effects of Hip Abductor and External Rotator Strength Training in Patients With Patellofemoral Pain Syndrome Completed NCT00736736
28 The Movement Control Training Associated With Conventional Physical Therapy is More Effective Than Conventional Physical Therapy Alone in Pain and Functional Performance? Completed NCT02624245
29 Dosage-dependence of Graded Exercise Therapy in Patients With Patellofemoral Pain Syndrome. A Randomized Controlled Clinical Trial. Completed NCT01290705
30 Effects of Lumbopelvic Manipulation on Hip and Knee Neuromuscular Activity in People With and Without Patellofemoral Pain Syndrome Completed NCT01637480
31 The Effects of Distal Femoral Rotation on Patellofemoral Pain Syndrome Treated With Patella Taping Completed NCT01504100
32 Effect of Lumbopelvic Manipulation on Hip and Knee Neuromuscular Activity, Pain Intensity, and Functional Activity in People With Patellofemoral Pain Syndrome. Completed NCT01975311
33 Investigation of Muscle Activity Pattern of Gluteus Medius and Tensor Fascia Lata in Patients With PFPS Completed NCT00451438
34 A Randomized Clinical Trial Comparing Two Chiropractic Protocols for Patellofemoral Pain Syndrome: a Pilot Study Completed NCT00401050
35 TTherapeutic Effect of Two Muscle Strengthening Programs in Patients With Patellofemoral Pain Syndrome From Bogota, Colombia. Experimental Study, Clinical Controlled Trial Completed NCT04011436
36 Clinical Subgroups Identification in Patellofemoral Pain Syndrome Patients Completed NCT03201133
37 Effects of Trigger Point Dry Needling In Patient With Patellofemoral Pain Syndrome Completed NCT03966937
38 Conventional Home Exercise Programs Versus Electronic Home Exercise Versus Artificial Intelligence "Virtual Therapy" for Anterior Knee Pain: a Prospective Randomized Comparative Trial. Completed NCT01696162
39 5 Year Follow-up of Adolescents With Knee Pain - a Prospective Cohort Study of 504 Adolescents Completed NCT02873143
40 Comparison of Short-Term Effects of Mobilization With Movement and Kinesiotaping on Pain, Function and Balance in Patellofemoral Pain Syndrome: A Randomized Control Completed NCT02707679
41 Association Between Ankle Dorsiflexion and Frontal Projection Angle During a Functional Task in the Patellofemoral Pain Syndrome Completed NCT03897569
42 Correlation Between the Amplitude of Ankle Dorsiflexion and Occurrence of Patellofemoral Pain Syndrome Completed NCT03213015
43 The Effect of Kinesio Taping® on Motor Control in Patients With Patellofemoral Pain Syndrome Completed NCT03117205
44 The Clinical Effects of Dry Needling & Kinesio Tape on Myofascial Trigger Point in the Vastus Lateralis Muscle in Subjects With PFPS Completed NCT02118246
45 The Effects and Predictors of Patella Taping in the Treatment of Patellafemoral Pain Syndrome Completed NCT01727596
46 Validity and Reliability of Autocad Software Assessment of Joint Position Sense in Patellofemoral Pain Syndrome Completed NCT03685812
47 A Randomized, Pragmatic, Effectiveness Trial Evaluating Intra-articular Hyaluronan for the Symptomatic Treatment of Chronic Patellofemoral Pain Syndrome Completed NCT01811654
48 Comparison of Early Hip Strengthening to Early Quadriceps Strengthening in the Treatment of Females With Patellofemoral Pain Completed NCT00445224
49 Spinal Manipulation for Improving Hip and Knee Muscle Strength in Patients With Patellofemoral Pain Syndrome - A Randomized, Placebo-Controlled, Clinical Trial Completed NCT03101956
50 Dynamic Quadriceps Muscle Stimulation for Treatment of Patellofemoral Pain Completed NCT02243332

Search NIH Clinical Center for Patellofemoral Pain Syndrome

Cochrane evidence based reviews: patellofemoral pain syndrome

Genetic Tests for Patellofemoral Pain Syndrome

Anatomical Context for Patellofemoral Pain Syndrome

MalaCards organs/tissues related to Patellofemoral Pain Syndrome:

41
Testes, Bone, Heart

Publications for Patellofemoral Pain Syndrome

Articles related to Patellofemoral Pain Syndrome:

(show top 50) (show all 616)
# Title Authors PMID Year
1
Sex Differences in Common Sports-Related Injuries. 38
30920893 2019
2
Electromyographic activity of knee vastii muscles during toe rise and heel rock tasks in women with patellofemoral pain syndrome in two phases of the menstrual cycle. 38
31408276 2019
3
The effect of patellar taping on lower extremity running kinematics in individuals with patellofemoral pain syndrome. 38
29601217 2019
4
Effects of neuromuscular training on pain intensity and self-reported functionality for patellofemoral pain syndrome in runners: study protocol for a randomized controlled clinical trial. 38
31288849 2019
5
Effect of a Commercially Available Footwear Insole on Biomechanical Variables Associated With Common Running Injuries. 38
31241539 2019
6
Cycling with Low Saddle Height is Related to Increased Knee Adduction Moments in Healthy Recreational Cyclists. 38
31269871 2019
7
Static patella tilt and axial engagement in knee extension are mainly influenced by knee torsion, the tibial tubercle-trochlear groove distance (TTTG), and trochlear dysplasia but not by femoral or tibial torsion. 38
31267191 2019
8
Distal femoral torsional osteotomy increases the contact pressure of the medial patellofemoral joint in biomechanical analysis. 38
30269169 2019
9
Women's Sports Medicine Programs in the United States: an interdisciplinary approach to the care of girls and women. 38
31213108 2019
10
Electromyographic activity of the quadriceps and gluteus medius muscles during/different straight leg raise and squat exercises in women with patellofemoral pain syndrome. 38
31185341 2019
11
Effect of muscle strengthening on perceived pain and static knee angles in young subjects with patellofemoral pain syndrome. 38
31316941 2019
12
The Effect of Valgus Control Instruction Exercises on Pain, Strength, and Functionality in Active Females With Patellofemoral Pain Syndrome. 38
31034336 2019
13
Ultrasonographic assessment of quadriceps and patellar tendon thicknesses in patients with patellofemoral pain syndrome. 38
31103417 2019
14
Comparison of Protonics™ Knee Brace to Sport Cord on Knee Pain and Function in Patients With Patellofemoral Pain Syndrome: A Randomized Controlled Trial. 38
31034316 2019
15
Bioelectrical Activity of Vastus Medialis and Rectus Femoris Muscles in Recreational Runners with Anterior Knee Pain. 38
30988842 2019
16
Validation of the Arabic version of the Kujala patellofemoral pain scoring system. 38
30316659 2019
17
Effects of Core Neuromuscular Training on Pain, Balance, and Functional Performance in Women With Patellofemoral Pain Syndrome: A Clinical Trial. 38
31193229 2019
18
The Proportion of Lower Limb Running Injuries by Gender, Anatomical Location and Specific Pathology: A Systematic Review. 38
30787648 2019
19
Geometry of Torsional Malalignment Syndrome: Trochlear Dysplasia but Not Torsion Predicts Lateral Patellar Instability. 38
30906795 2019
20
Clinical results of pulsed signal therapy on patellofemoral syndrome with patellar chondropathy. 38
30763468 2019
21
Added Value of Isolated Core Postural Control Training on Knee Pain and Function in Women With Patellofemoral Pain Syndrome: A Randomized Controlled Trial. 38
30267667 2019
22
Is there a correlation in frontal plane knee kinematics between running and performing a single leg squat in runners with patellofemoral pain syndrome and asymptomatic runners? 38
30634094 2019
23
Efficacy of High-Power Laser in Alleviating Pain and Improving Function of Patients With Patellofemoral Pain Syndrome: A Single-Blind Randomized Controlled Trial. 38
31360367 2019
24
Alterations in energy consumption and plantar pressure distribution during walking in young adults with patellofemoral pain syndrome. 38
30482589 2019
25
Trunk postural control during unstable sitting differs between patients with patellofemoral pain syndrome and healthy people: A cross-sectional study. 38
30472048 2019
26
The Effect of Diacutaneous Fibrolysis on Patellar Position Measured Using Ultrasound Scanning in Patients With Patellofemoral Pain Syndrome. 38
29651911 2019
27
Efficacy of Kinesio Taping and McConnell Taping Techniques in the Management of Anterior Knee Pain. 38
30526288 2019
28
Research Methods and Progress of Patellofemoral Joint Kinematics: A Review. 38
31019669 2019
29
Patellofemoral Pain Syndrome. 38
30633489 2019
30
Patellofemoral Pain Syndrome. 38
30633480 2019
31
Knee Orthoses for Treating Patellofemoral Pain Syndrome. 38
30676579 2019
32
Neurodynamic tests for patellofemoral pain syndrome: a pilot study. 38
31080579 2019
33
[Correction of the lumbosacral orthosis in the patients presenting with patellofemoral pain syndrome with the use of physical exercise therapy]. 38
31095127 2019
34
The Influence of Tibial Tuberosity-trochlear Groove Distance on Development of Patellofemoral Pain Syndrome. 38
30805415 2019
35
Braces and Splints for Common Musculoskeletal Conditions. 38
30365284 2018
36
Biophysical stimulation of the knee with PEMFs: from bench to bedside. 38
30644277 2018
37
Femoral malrotation from diaphyseal fractures results in changes in patellofemoral alignment and higher patellofemoral stress from a finite element model study. 38
30060996 2018
38
Quadriceps force production during straight leg raising at different hip positions with and without concomitant ankle dorsiflexion. 38
30368333 2018
39
Progression in Running Intensity or Running Volume and the Development of Specific Injuries in Recreational Runners: Run Clever, a Randomized Trial Using Competing Risks. 38
29895234 2018
40
Dynamic postural control during step down task in patients with patellofemoral pain syndrome. 38
30349166 2018
41
Electromyographic analysis of hip and knee muscles during specific exercise movements in females with patellofemoral pain syndrome: An observational study. 38
29995792 2018
42
Squatting Re-education With Lumbo-Pelvic-Thigh Muscle Cocontraction Improves Functional Performance in Patellofemoral Pain Syndrome: A Case Presentation. 38
29133185 2018
43
SHORT-TERM EFFECTS OF TRIGGER POINT DRY NEEDLING ON PAIN AND DISABILITY IN SUBJECTS WITH PATELLOFEMORAL PAIN SYNDROME. 38
30038832 2018
44
IS MULTI-JOINT OR SINGLE JOINT STRENGTHENING MORE EFFECTIVE IN REDUCING PAIN AND IMPROVING FUNCTION IN WOMEN WITH PATELLOFEMORAL PAIN SYNDROME? A SYSTEMATIC REVIEW AND META-ANALYSIS. 38
30038822 2018
45
The effects of joint mobilization on individuals with patellofemoral pain: a systematic review. 38
29327606 2018
46
Use of an Elastomeric Knee Brace in Patellofemoral Pain Syndrome: Short-Term Results. 38
30051103 2018
47
Current clinical, radiological and treatment perspectives of patellofemoral pain syndrome. 38
29303366 2018
48
Effectiveness of conservative treatment for patellofemoral pain syndrome: A systematic review and meta-analysis. 38
29392329 2018
49
Effects of Anterior Knee Displacement During Squatting on Patellofemoral Joint Stress. 38
28422563 2018
50
Differences in Hip and Knee Running Moments across Female Pubertal Development. 38
29252969 2018

Variations for Patellofemoral Pain Syndrome

Expression for Patellofemoral Pain Syndrome

Search GEO for disease gene expression data for Patellofemoral Pain Syndrome.

Pathways for Patellofemoral Pain Syndrome

Pathways related to Patellofemoral Pain Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.83 SAMHD1 GDF6

GO Terms for Patellofemoral Pain Syndrome

Sources for Patellofemoral Pain Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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