MCID: PTL002
MIFTS: 31

Patellofemoral Pain Syndrome

Categories: Bone diseases

Aliases & Classifications for Patellofemoral Pain Syndrome

MalaCards integrated aliases for Patellofemoral Pain Syndrome:

Name: Patellofemoral Pain Syndrome 12 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:14284
MeSH 43 D046788
UMLS 71 C0877149

Summaries for Patellofemoral Pain Syndrome

MalaCards based summary : Patellofemoral Pain Syndrome is related to tendinitis and plica syndrome, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Patellofemoral Pain Syndrome is HECTD4 (HECT Domain E3 Ubiquitin Protein Ligase 4). The drugs Acetylcholine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and heart.

Wikipedia : 74 Patellofemoral pain syndrome (PFPS), also known as runner's knee, is knee pain as a result of problems... more...

Related Diseases for Patellofemoral Pain Syndrome

Diseases related to Patellofemoral Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 tendinitis 30.8 PES1 HECTD4
2 plica syndrome 30.5 SHANK2 PES1
3 osgood-schlatter's disease 30.5 PES1 HECTD4
4 bursitis 30.4 PES1 LAPTM4A HECTD4
5 osteochondrosis 30.3 PES1 HECTD4
6 chondromalacia 10.4
7 achilles bursitis 10.3 PES1 HECTD4
8 heel spur 10.3 PES1 HECTD4
9 de quervain disease 10.3 PES1 HECTD4
10 tarsal tunnel syndrome 10.3 PES1 HECTD4
11 tibial neuropathy 10.3 PES1 HECTD4
12 peroneal nerve paralysis 10.3 PES1 HECTD4
13 kohler's disease 10.3 PES1 HECTD4
14 patellar tendinitis 10.3 PES1 HECTD4
15 patella, chondromalacia of 10.3
16 calcific tendinitis 10.3 PES1 HECTD4
17 synostoses, tarsal, carpal, and digital 10.3 PES1 HECTD4
18 tinea pedis 10.3 PES1 HECTD4
19 tenosynovitis 10.3 PES1 HECTD4
20 lumbosacral lipoma 10.3 PES1 HECTD4
21 myofascial pain syndrome 10.3 LAPTM4A HECTD4
22 ichthyosis, congenital, autosomal recessive 9 10.3 PES1 HECTD4
23 mononeuropathy 10.2 PES1 HECTD4
24 frozen shoulder 10.2
25 nerve compression syndrome 10.2 PES1 HECTD4
26 polyradiculopathy 10.2 LAPTM4A HECTD4
27 radiculopathy 10.2 LAPTM4A HECTD4
28 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
29 body mass index quantitative trait locus 1 10.1
30 paine syndrome 10.1 LAPTM4A HECTD4
31 ischemic bone disease 10.1 PES1 HECTD4
32 spastic hemiplegia 10.1 SHANK2 PES1 HECTD4
33 hemiplegia 10.1 SHANK2 PES1 HECTD4
34 spastic diplegia 10.1 SHANK2 PES1 HECTD4
35 spastic cerebral palsy 10.1 SHANK2 PES1 HECTD4
36 exostosis 10.1 PES1 HECTD4
37 epicondylitis 10.1 PES1 LAPTM4A HECTD4
38 leukemia, acute lymphoblastic 3 10.0
39 tendinopathy 10.0
40 alexithymia 10.0
41 arthropathy 10.0
42 osteochondritis dissecans 10.0
43 acute mountain sickness 10.0
44 bunion 10.0
45 chronic pain 10.0
46 dysautonomia 10.0
47 overuse syndrome 10.0
48 somatoform disorder 10.0 LAPTM4A HECTD4
49 arthropathy, progressive pseudorheumatoid, of childhood 10.0 TRAPPC2B TRAPPC2
50 optic atrophy 10 with or without ataxia, mental retardation, and seizures 10.0 TRAPPC2B TRAPPC2

Graphical network of the top 20 diseases related to Patellofemoral Pain Syndrome:



Diseases related to Patellofemoral Pain Syndrome

Symptoms & Phenotypes for Patellofemoral Pain Syndrome

UMLS symptoms related to Patellofemoral Pain Syndrome:


arthralgia, metatarsalgia

Drugs & Therapeutics for Patellofemoral Pain Syndrome

Drugs for Patellofemoral Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
2
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
3
Imidacloprid Vet_approved Phase 3 105827-78-9 86418
4 Neurotransmitter Agents Phase 3
5 abobotulinumtoxinA Phase 3
6 Cholinergic Agents Phase 3
7 Botulinum Toxins Phase 3
8 Botulinum Toxins, Type A Phase 3
9 Hylan Phase 2
10
Povidone-iodine Approved 25655-41-8
11
Sulfamethazine Approved, Investigational, Vet_approved 57-68-1 5327
12
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
13
tannic acid Approved 1401-55-4
14
Phenylephrine Approved 59-42-7 6041
15
Oxymetazoline Approved, Investigational 1491-59-4 4636
16
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
17
Ethanol Approved 64-17-5 702
18 Orange Approved
19
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
20
Acetaminophen Approved 103-90-2 1983
21 Viscosupplements
22 Protective Agents
23 Adjuvants, Immunologic
24 Immunologic Factors
25 Astragalus
26 Anesthetics
27 Aluminum hydroxide, magnesium hydroxide, simethicone drug combination
28 TEMPO
29 Analgesics
30 Analgesics, Non-Narcotic
31 Antipyretics

Interventional clinical trials:

(show top 50) (show all 116)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Diacutaneous Fibrolysis Technique on Pain, Range of Motion, Strength and Function in Patients With Patellofemoral Pain Syndrome Completed NCT02379364 Phase 3
2 Foot Orthotics in the Treatment of Patellofemoral Pain Syndrome: A Randomised Clinical Trial in Primary Care Completed NCT00118521 Phase 3
3 A Prospective Randomized Study Comparing the Outcome of Electrical Stimulation of Vastus Medialis Obliquus Muscle and Physical Therapy vs Only Physical Therapy But no Electrical Stimulation in Patients With Patellofemoral Pain Syndrome Recruiting NCT03184545 Phase 3
4 Botox for Non-surgical Lateral Release in Patellofemoral Pain Terminated NCT00496964 Phase 3 Botulinum toxin A + exercise;Placebo
5 Comparison of The Clinical Effects Between Different Physical Therapy Tools in Patellofemoral Pain Patients Unknown status NCT00451347 Phase 1, Phase 2
6 Intra-articular Hyaluronic Acid Injection for Therapy-resistant Patellofemoral Pain Syndrome: an Open-label, Randomized, Delayed-start Clinical Trial Unknown status NCT02613247 Phase 2
7 Quadriceps Femoris Strengthening Versus Hamstring Stretching for Patellofemoral Pain Syndrome: A Randomized Clinical Trial. Completed NCT01691170 Phase 1, Phase 2
8 Treatment for Patellofemoral Pain Syndrome Using Knee Abduction Moment-Reducing Footwear Completed NCT01332110 Phase 1, Phase 2
9 Assessing Foot Injuries in Infantry Recruits Wearing Different Boots, a Prospective Randomized Study Completed NCT02810002 Phase 1, Phase 2
10 Effect of Hip Adduction Combination With Knee Extension Exercise on Morphology of Quadriceps Muscles, Pain and Functional Outcomes in Patients With PFPS Unknown status NCT00166777 Phase 1
11 Phase 1 Study: Comparison of Electromechanical Delay Phase 2 Study: Research in Viscoelasticity of Tendon Structures Phase 3 Study: Effects of Exercise Training in the Mechanical Properties Unknown status NCT00451087 Phase 1
12 Immediate Effect of Selective Neuromuscular Electrical Stimulation of Vastus Medialis Obliquus in Women With Patellofemoral Pain Syndrome Unknown status NCT02548988
13 The Effects of a Trunk Strengthening Program on Anterior Knee Pain in an Adolescent Athletic Population: a Randomized Clinical Trial Unknown status NCT02123602
14 The Effect of Muscle Strengthening Associated With Neuromuscular Stimulus in Patients With Patellofemoral Pain During Negotiating Stairs: A Randomized Controlled Trial Unknown status NCT02591680
15 Foot Orthoses in Patellofemoral Pain Syndrome: a Prospective Randomized Study of Morpho-specific Versus Placebo Orthoses Unknown status NCT02250144
16 The Role of Quadriceps Contraction in Patellar Repositioning-a Computed Tomography Study Unknown status NCT00760136
17 Effect of Star Excursion Balance Test on Balance, Quality of Life and Functional Status in Patients With Patellofemoral Pain Syndrome Unknown status NCT03364855
18 Morphology of the Vastus Medialis Obliquus in Patients With Patellofemoral Pain Syndrome and Healthy Young Adults --A Sonographic Study Unknown status NCT00173147
19 Does Isolated Hip Strengthening for Patellofemoral Pain Syndrome Give Better Long Term Results Than Traditional Quadriceps Based Training? A Randomised Controlled Trial. Unknown status NCT02114294
20 Effects of Kinesio Taping in Painful and Neuromuscular Performance of Patients With Patellofemoral Pain Unknown status NCT02827084
21 The Additional Effect of First Metatarsophalangeal Joint Correction on Runners With First Ray Instability and Patellofemoral Pain Syndrome Unknown status NCT03468491
22 Can Lower Extremity Overuse Injuries Be Prevented by an Exercise Program Aiming at Muscular Strength, Flexibility and Coordination – a RCT Unknown status NCT00348647
23 Shock Wave Therapy Versus Neuromuscular Training in Women With Patellofemoral Pain Unknown status NCT03324204
24 Prospective, Randomized, Double Blind Evaluation of the Efficacy of a Single Dose of Synvisc-One® (6.0 cc) for the Treatment of Patellofemoral Chondromalacia Unknown status NCT01771952
25 Kinematics of Lower Limb, Pain and Function of the Women With Patellofemoral Pain Syndrome Who Underwent Two Types Treatment: Randomized Clinical Trial Completed NCT01804608
26 Effects of Hip Abductor and External Rotator Strength Training in Patients With Patellofemoral Pain Syndrome Completed NCT00736736
27 The Movement Control Training Associated With Conventional Physical Therapy is More Effective Than Conventional Physical Therapy Alone in Pain and Functional Performance? Completed NCT02624245
28 Dosage-dependence of Graded Exercise Therapy in Patients With Patellofemoral Pain Syndrome. A Randomized Controlled Clinical Trial. Completed NCT01290705
29 Effects of Lumbopelvic Manipulation on Hip and Knee Neuromuscular Activity in People With and Without Patellofemoral Pain Syndrome Completed NCT01637480
30 The Effects of Distal Femoral Rotation on Patellofemoral Pain Syndrome Treated With Patella Taping Completed NCT01504100
31 Effect of Lumbopelvic Manipulation on Hip and Knee Neuromuscular Activity, Pain Intensity, and Functional Activity in People With Patellofemoral Pain Syndrome. Completed NCT01975311
32 Investigation of Muscle Activity Pattern of Gluteus Medius and Tensor Fascia Lata in Patients With PFPS Completed NCT00451438
33 A Randomized Clinical Trial Comparing Two Chiropractic Protocols for Patellofemoral Pain Syndrome: a Pilot Study Completed NCT00401050
34 TTherapeutic Effect of Two Muscle Strengthening Programs in Patients With Patellofemoral Pain Syndrome From Bogota, Colombia. Experimental Study, Clinical Controlled Trial Completed NCT04011436
35 The Effects of Foot Exercises on Pain, Biomechanical Characteristics and Functionality of Lower Extremity in Patients With Patellofemoral Pain Completed NCT03099512
36 Clinical Subgroups Identification in Patellofemoral Pain Syndrome Patients Completed NCT03201133
37 Effects of Trigger Point Dry Needling In Patient With Patellofemoral Pain Syndrome Completed NCT03966937
38 Conventional Home Exercise Programs Versus Electronic Home Exercise Versus Artificial Intelligence "Virtual Therapy" for Anterior Knee Pain: a Prospective Randomized Comparative Trial. Completed NCT01696162
39 Comparison of Short-Term Effects of Mobilization With Movement and Kinesiotaping on Pain, Function and Balance in Patellofemoral Pain Syndrome: A Randomized Control Completed NCT02707679
40 5 Year Follow-up of Adolescents With Knee Pain - a Prospective Cohort Study of 504 Adolescents Completed NCT02873143
41 Comparison of Mobilization With Movement and Mulligan Knee Taping Technique on Patellofemoral Pain Syndrome. Completed NCT04173468
42 Correlation Between the Amplitude of Ankle Dorsiflexion and Occurrence of Patellofemoral Pain Syndrome Completed NCT03213015
43 Association Between Ankle Dorsiflexion and Frontal Projection Angle During a Functional Task in the Patellofemoral Pain Syndrome Completed NCT03897569
44 The Effect of Kinesio Taping® on Motor Control in Patients With Patellofemoral Pain Syndrome Completed NCT03117205
45 The Effects and Predictors of Patella Taping in the Treatment of Patellafemoral Pain Syndrome Completed NCT01727596
46 The Clinical Effects of Dry Needling & Kinesio Tape on Myofascial Trigger Point in the Vastus Lateralis Muscle in Subjects With PFPS Completed NCT02118246
47 Validity and Reliability of Autocad Software Assessment of Joint Position Sense in Patellofemoral Pain Syndrome Completed NCT03685812
48 A Randomized, Pragmatic, Effectiveness Trial Evaluating Intra-articular Hyaluronan for the Symptomatic Treatment of Chronic Patellofemoral Pain Syndrome Completed NCT01811654
49 Comparison of Early Hip Strengthening to Early Quadriceps Strengthening in the Treatment of Females With Patellofemoral Pain Completed NCT00445224
50 Dynamic Quadriceps Muscle Stimulation for Treatment of Patellofemoral Pain Completed NCT02243332

Search NIH Clinical Center for Patellofemoral Pain Syndrome

Cochrane evidence based reviews: patellofemoral pain syndrome

Genetic Tests for Patellofemoral Pain Syndrome

Anatomical Context for Patellofemoral Pain Syndrome

MalaCards organs/tissues related to Patellofemoral Pain Syndrome:

40
Testes, Bone, Heart

Publications for Patellofemoral Pain Syndrome

Articles related to Patellofemoral Pain Syndrome:

(show top 50) (show all 642)
# Title Authors PMID Year
1
Patellofemoral Pain Syndrome and Pain Severity Is Associated With Asymmetry of Gluteus Medius Muscle Activation Measured Via Ultrasound. 61
31860586 2020
2
Immediate effects of an elastic patellar brace on pain, neuromuscular activity and knee kinematics in subjects with patellofemoral pain. 61
32108253 2020
3
Taping, Bracing, and Injection Treatment for Patellofemoral Pain and Patellar Tendinopathy. 61
32500350 2020
4
Individuals with patellofemoral pain syndrome have altered inter-leg force coordination. 61
32361127 2020
5
Classifying individuals with and without patellofemoral pain syndrome using ground force profiles - Development of a method using functional data boosting. 61
32497981 2020
6
Validity and Reliability of the Indonesian Version of the Kujala Score for Patients With Patellofemoral Pain Syndrome. 61
32523969 2020
7
Zone- and layer-specific differences in proteoglycan content in patellofemoral pain syndrome are detectable on T1ρ MRI. 61
32253471 2020
8
Effects of McConnell taping combined with strengthening exercises of vastus medialis oblique in females with patellofemoral pain syndrome. 61
32296223 2020
9
Comparison of dry needling and ischaemic compression techniques on pain and function in patients with patellofemoral pain syndrome: a randomised clinical trial. 61
32338532 2020
10
Does Acute Fatigue Negatively Affect Intrinsic Risk Factors of the Lower Extremity Injury Risk Profile? A Systematic and Critical Review. 61
31782066 2020
11
Changes in Knee Vastii Muscle Activity in Women with Patellofemoral Pain Syndrome During the Menstrual Cycle. 61
31408276 2020
12
Electrical Stimulation Therapies for Active Duty Military with Patellofemoral Pain Syndrome: A Randomized Trial. 61
32248227 2020
13
Assessment and Management of Somatic Dysfunctions in Patients With Patellofemoral Pain Syndrome. 61
32091560 2020
14
Static patella tilt and axial engagement in knee extension are mainly influenced by knee torsion, the tibial tubercle-trochlear groove distance (TTTG), and trochlear dysplasia but not by femoral or tibial torsion. 61
31267191 2020
15
Effects of Posterior X Taping on Movement Quality and Knee Pain Intensity during Forward-Step-Down in Patients with Patellofemoral Pain Syndrome. 61
32132846 2020
16
Added Value of Gluteus Medius and Quadratus Lumborum Dry Needling in Improving Knee Pain and Function in Female Athletes With Patellofemoral Pain Syndrome: A Randomized Clinical Trial. 61
31465756 2020
17
Analysis of Running-Related Injuries: The Vienna Study. 61
32041127 2020
18
Women's Sports Medicine Programs in the United States: an interdisciplinary approach to the care of girls and women. 61
31213108 2020
19
Lower extremity alignment due to patellofemoral syndrome and dynamic postural balance. 61
32054433 2020
20
Investigation of different application techniques for Kinesio Taping® with an accompanying exercise protocol for improvement of pain and functionality in patients with patellofemoral pain syndrome: A pilot study. 61
31987562 2020
21
Prevalence and sensitivity of trigger points in lumbo-pelvic-hip muscles in patients with patellofemoral pain syndrome. 61
31987531 2020
22
Twelve-Week Gait Retraining Reduced Patellofemoral Joint Stress during Running in Male Recreational Runners. 61
32258162 2020
23
Electromyographic analysis of VMO and VL across straight leg raise, short arc quad, medial tibial rotation and hip adduction in normal individuals. 61
31868722 2020
24
Is neuromuscular electrical stimulation effective for management of patellofemoral pain syndrome? A Cochrane Review summary with commentary. 61
31550621 2019
25
Electromyographic activity of the quadriceps and gluteus medius muscles during/different straight leg raise and squat exercises in women with patellofemoral pain syndrome. 61
31185341 2019
26
Evidence based treatment options for common knee injuries in runners. 61
31728373 2019
27
Sex Differences in Common Sports-Related Injuries. 61
30920893 2019
28
The Effect of Diacutaneous Fibrolysis on Patellar Position Measured Using Ultrasound Scanning in Patients With Patellofemoral Pain Syndrome. 61
29651911 2019
29
The effect of patellar taping on lower extremity running kinematics in individuals with patellofemoral pain syndrome. 61
29601217 2019
30
Ultrasonographic assessment of quadriceps and patellar tendon thicknesses in patients with patellofemoral pain syndrome. 61
31103417 2019
31
Effects of neuromuscular training on pain intensity and self-reported functionality for patellofemoral pain syndrome in runners: study protocol for a randomized controlled clinical trial. 61
31288849 2019
32
Effect of a Commercially Available Footwear Insole on Biomechanical Variables Associated With Common Running Injuries. 61
31241539 2019
33
Cycling with Low Saddle Height is Related to Increased Knee Adduction Moments in Healthy Recreational Cyclists. 61
31269871 2019
34
Distal femoral torsional osteotomy increases the contact pressure of the medial patellofemoral joint in biomechanical analysis. 61
30269169 2019
35
Backward walking alters vastus medialis oblique/vastus lateralis muscle activity ratio in females with patellofemoral pain syndrome. 61
31453558 2019
36
Effect of muscle strengthening on perceived pain and static knee angles in young subjects with patellofemoral pain syndrome. 61
31316941 2019
37
The Effect of Valgus Control Instruction Exercises on Pain, Strength, and Functionality in Active Females With Patellofemoral Pain Syndrome. 61
31034336 2019
38
Comparison of Protonics™ Knee Brace to Sport Cord on Knee Pain and Function in Patients With Patellofemoral Pain Syndrome: A Randomized Controlled Trial. 61
31034316 2019
39
Effects of Core Neuromuscular Training on Pain, Balance, and Functional Performance in Women With Patellofemoral Pain Syndrome: A Clinical Trial. 61
31193229 2019
40
Bioelectrical Activity of Vastus Medialis and Rectus Femoris Muscles in Recreational Runners with Anterior Knee Pain. 61
30988842 2019
41
Validation of the Arabic version of the Kujala patellofemoral pain scoring system. 61
30316659 2019
42
The Proportion of Lower Limb Running Injuries by Gender, Anatomical Location and Specific Pathology: A Systematic Review. 61
30787648 2019
43
The effect of shear-wave elastography on functional results and muscle stiffness in patients undergoing non-selective and selective open kinetic chain exercises. 61
31453543 2019
44
Geometry of Torsional Malalignment Syndrome: Trochlear Dysplasia but Not Torsion Predicts Lateral Patellar Instability. 61
30906795 2019
45
Clinical results of pulsed signal therapy on patellofemoral syndrome with patellar chondropathy. 61
30763468 2019
46
Added Value of Isolated Core Postural Control Training on Knee Pain and Function in Women With Patellofemoral Pain Syndrome: A Randomized Controlled Trial. 61
30267667 2019
47
Efficacy of High-Power Laser in Alleviating Pain and Improving Function of Patients With Patellofemoral Pain Syndrome: A Single-Blind Randomized Controlled Trial. 61
31360367 2019
48
Is there a correlation in frontal plane knee kinematics between running and performing a single leg squat in runners with patellofemoral pain syndrome and asymptomatic runners? 61
30634094 2019
49
[Correction of the lumbosacral orthosis in the patients presenting with patellofemoral pain syndrome with the use of physical exercise therapy]. 61
31095127 2019
50
Effects of balance taping using kinesiology tape in a female with patellofemoral pain syndrome: A case report. 61
31771039 2019

Variations for Patellofemoral Pain Syndrome

Expression for Patellofemoral Pain Syndrome

Search GEO for disease gene expression data for Patellofemoral Pain Syndrome.

Pathways for Patellofemoral Pain Syndrome

GO Terms for Patellofemoral Pain Syndrome

Cellular components related to Patellofemoral Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TRAPP complex GO:0030008 8.62 TRAPPC2B TRAPPC2

Sources for Patellofemoral Pain Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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