Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
OSASD
MCID: PTN001
MIFTS: 58

Patent Foramen Ovale (OSASD)

Categories: Blood diseases, Cardiovascular diseases, Fetal diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Patent Foramen Ovale

About this section

MalaCards integrated aliases for Patent Foramen Ovale:

Name: Patent Foramen Ovale 12 29 6 15
Foramen Ovale, Patent 44 73
Foramen Ovale Patent 12 55
Defect, Patent or Persistent, Ostium Secundum 12
Atrial Septal Defect, Ostium Secundum Type 59
Ostium Secundum Type Atrial Septal Defect 12
Atrial Septal Defect Within Oval Fossa 12
Ostium Secundum Atrial Septal Defect 53
Persistent Ostium Secundum 12
Asd, Ostium Secundum Type 59
Asd Ostium Secundum Type 53
Ostium Secundum Asd 53
Osasd 53

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Cardiovascular diseases Respiratory diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare cardiac malformations
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 12 DOID:13620
ICD10 33 Q21.1
MeSH 44 D054092
NCIt 50 C34619
SNOMED-CT 68 78902000
Orphanet 59 ORPHA99103
UMLS via Orphanet 74 C0344724
ICD10 via Orphanet 34 Q21.1
UMLS 73 C0016522
Sources

Summaries for Patent Foramen Ovale

About this section
NIH Rare Diseases : 53 An ostium secundum atrial septal defect is a type of congenital heart defect called an atrial septal defect (ASD). An ASD is a hole in the wall (septum) between the two upper chambers of the heart (the atria). ASDs can be classified by location. An ostium secundum ASD is a hole in the center of the atrial septum. Normally, the right side of the heart pumps oxygen-poor blood to the lungs, while the left side pumps oxygen-rich blood to the body. An ASD allows blood from both sides to mix, causing the heart to work less efficiently. A small hole may not cause any symptoms or problems. A larger hole can eventually cause symptoms such as shortness of breath, respiratory infections, fainting, irregular heart rhythms or fatigue after mild activity. Larger ASDs can also ultimately lead to pulmonary artery hypertension, right ventricular hypertrophy (enlargement); SVT, or heart failure. Most cases of ASD are not inherited and occur by chance. Some cases appear to have autosomal dominant inheritance. Treatment may not be needed for small ASDs, which often close on their own. Larger ASDs are typically closed during childhood with open heart surgery or by cardiac catheterization.

MalaCards based summary : Patent Foramen Ovale, also known as foramen ovale, patent, is related to pulmonary embolism and thrombosis. An important gene associated with Patent Foramen Ovale is TBX5 (T-Box 5), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Atrial septal defect (ASD) is a heart defect in which blood flows between the atria (upper chambers) of... more...

Sources

Related Diseases for Patent Foramen Ovale

About this section

Diseases related to Patent Foramen Ovale via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 pulmonary embolism 31.7 APOH F2 F5 MTHFR SERPINC1
2 thrombosis 31.3 APOH F2 F5 MTHFR SERPINC1
3 endocarditis 31.3 APOH F2 SERPINC1
4 stroke, ischemic 31.2 APOH F2 F5 MTHFR SERPINC1
5 myocardial infarction 31.2 F2 F5 GATA4 MTHFR SERPINC1
6 intracranial embolism 31.2 F12 F2 SERPINC1
7 atrial heart septal defect 31.0 ACTC1 F2 GATA4 GATA6 MYH6 NKX2-5
8 retinal artery occlusion 31.0 APOH F2 F5 MTHFR SERPINC1
9 thrombophilia due to thrombin defect 31.0 APOH F2 F5 MTHFR SERPINC1
10 may-thurner syndrome 31.0 APOH F5
11 thrombophilia 31.0 APOH F2 F5 MTHFR SERPINC1
12 antiphospholipid syndrome 30.9 APOH F2 F5 MTHFR SERPINC1
13 transposition of the great arteries 30.9 MED13L NKX2-5
14 branch retinal artery occlusion 30.7 APOH F2 MTHFR SERPINC1
15 patent ductus arteriosus 1 30.7 GATA4 GATA6 NKX2-5 PTPN11 TLL1
16 pulmonary valve stenosis 30.6 GATA4 PTPN11
17 amaurosis fugax 30.6 F5 MTHFR
18 sudden sensorineural hearing loss 30.5 APOH F2 F5 MTHFR
19 sticky platelet syndrome 30.5 F5 SERPINC1
20 cerebrovascular disease 30.5 F12 F2 F5 MTHFR
21 hypoplastic left heart syndrome 30.5 MYH6 NKX2-5 TBX20
22 spinal cord infarction 30.4 APOH F2 F5 MTHFR SERPINC1
23 budd-chiari syndrome 30.4 APOH F2 F5 MTHFR SERPINC1
24 ventricular septal defect 30.3 CITED2 GATA4 GATA6 NKX2-5 TBX5
25 heart disease 30.1 ACTC1 CITED2 F2 GATA4 GATA6 MED13L
26 tetralogy of fallot 30.0 CITED2 GATA4 GATA6 MTHFR NKX2-5 PTPN11
27 mental retardation and distinctive facial features with or without cardiac defects 11.5
28 right pulmonary artery, anomalous origin of, familial 11.5
29 tricuspid atresia 11.4
30 short stature, developmental delay, and congenital heart defects 11.4
31 right ventricle hypoplasia 11.4
32 atrial septal aneurysm 10.9
33 transient cerebral ischemia 10.8
34 migraine with aura 10.6
35 atrial fibrillation 10.6
36 headache 10.6
37 sleep apnea 10.6
38 pulmonary hypertension 10.6
39 ischemia 10.6
40 pulmonary edema 10.5
41 acute mountain sickness 10.5
42 migraine with or without aura 1 10.5
43 pulmonic stenosis 10.5
44 hypoxia 10.5
45 acute myocardial infarction 10.4
46 infective endocarditis 10.4
47 tricuspid valve insufficiency 10.4
48 acute respiratory distress syndrome 10.4
49 paracetamol poisoning 10.3 F2 F5
50 familial progressive cardiac conduction defect 10.3 NKX2-5 TRPM4

Graphical network of the top 20 diseases related to Patent Foramen Ovale:



Diseases related to Patent Foramen Ovale
Sources

Symptoms & Phenotypes for Patent Foramen Ovale

About this section

GenomeRNAi Phenotypes related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.98 F12
2 Decreased viability GR00402-S-2 9.98 AAR2 ACTC1 APOH CITED2 F12 F2
3 no effect GR00402-S-1 9.62 AAR2 ACTC1 APOH CITED2 F12 F2

MGI Mouse Phenotypes related to Patent Foramen Ovale:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.37 ACTC1 CITED2 F2 F5 GATA4 GATA6
2 homeostasis/metabolism MP:0005376 10.36 ACTC1 APOH CITED2 F12 F2 F5
3 growth/size/body region MP:0005378 10.27 ACTC1 CITED2 F2 F5 GATA4 GATA6
4 mortality/aging MP:0010768 10.22 ACTC1 APOH CITED2 F2 F5 GATA4
5 embryo MP:0005380 10.18 CITED2 F2 F5 GATA4 GATA6 NKX2-5
6 liver/biliary system MP:0005370 10.02 F5 GATA4 GATA6 MTHFR MYH6 PTPN11
7 limbs/digits/tail MP:0005371 9.95 CITED2 GATA4 GATA6 MTHFR PTPN11 TBX5
8 muscle MP:0005369 9.91 ACTC1 GATA4 GATA6 MYH6 NKX2-5 PTPN11
9 nervous system MP:0003631 9.85 CITED2 F12 F2 F5 GATA4 MTHFR
10 normal MP:0002873 9.65 ACTC1 CITED2 F12 F2 GATA4 GATA6
11 respiratory system MP:0005388 9.17 CITED2 F2 GATA4 GATA6 MYH6 NKX2-5
Sources

Drugs & Therapeutics for Patent Foramen Ovale

About this section

Drugs for Patent Foramen Ovale (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-78-2 2244
2
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 113665-84-2, 120202-66-6 60606
3
Warfarin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81-81-2 6691 54678486
4 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Not Applicable
5 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
6 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
7 Antipyretics Phase 4,Phase 2,Phase 3,Not Applicable
8 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Anticoagulants Phase 4,Phase 3,Phase 2
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Not Applicable
12 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
13 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
15 Coagulants Phase 4
16
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
17
Rivaroxaban Approved Phase 3 366789-02-8
18
Dipyridamole Approved Phase 3,Not Applicable 58-32-2 3108
19
Apixaban Approved Phase 3,Phase 2 503612-47-3 10182969
20
Serine Approved, Nutraceutical Phase 3,Phase 2 56-45-1 5951
21 Serine Proteinase Inhibitors Phase 3,Phase 2
22 Dabigatran Phase 3
23
protease inhibitors Phase 3,Phase 2
24 Factor Xa Inhibitors Phase 3,Phase 2
25 Antivitamins K Phase 3
26 Antithrombins Phase 3,Phase 2
27 Aspirin, Dipyridamole Drug Combination Phase 3,Not Applicable
28 Antithrombin III Phase 3,Phase 2
29 HIV Protease Inhibitors Phase 3,Phase 2
30 Pharmaceutical Solutions Phase 3,Phase 2
31
Polidocanol Approved Phase 2 9002-92-0
32
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
33
Dalteparin Approved Phase 2 9005-49-6
34 calcium heparin Phase 2
35 Antidepressive Agents Phase 2
36 Calcium, Dietary Phase 2
37 Purinergic P2 Receptor Antagonists Phase 2
38 Heparin, Low-Molecular-Weight Phase 2
39 Neurotransmitter Agents Phase 2,Not Applicable
40 Purinergic P2Y Receptor Antagonists Phase 2
41 Anticonvulsants Phase 2
42 Calamus Phase 2,Not Applicable
43 tannic acid Approved
44
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
45
Tocopherol Approved, Investigational Not Applicable 1406-66-2 14986
46
Iodine Approved, Investigational Not Applicable 7553-56-2 807
47
Nitric Oxide Approved Not Applicable 10102-43-9 145068
48
Vitamin E Approved, Nutraceutical, Vet_approved Not Applicable 59-02-9 14985
49
Vitamin C Approved, Nutraceutical Not Applicable 50-81-7 5785 54670067
50
N,N-dimethylarginine Experimental Not Applicable 30315-93-6 123831

Interventional clinical trials:

(show top 50) (show all 79)
# Name Status NCT ID Phase Drugs
1 PC-Trial: Patent Foramen Ovale and Cryptogenic Embolism Unknown status NCT00166257 Phase 4 Medical antitrhombotic treatment
2 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Unknown status NCT02509754 Phase 4
3 Patent Foramen Ovale in Cryptogenic Stroke Study Completed NCT00697151 Phase 4 Warfarin;Aspirin
4 Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) Recruiting NCT01550588 Phase 4 Standard medical treatment
5 Evaluation of the STARFlex® Septal Closure System in Patients With a Stroke or TIA Due to the Possible Passage of a Clot of Unknown Origin Through a Patent Foramen Ovale (PFO) Unknown status NCT00201461 Phase 2, Phase 3 Best medical therapy
6 MIST II PFO-Migraine Trial With BioSTAR® Bioabsorbable Septal Repair Implant Unknown status NCT00283738 Phase 2, Phase 3
7 Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence Completed NCT00562289 Phase 3 aspirin;Antivitamins K or rivaroxaban or dabigatran or apixaban
8 Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent Completed NCT00506493 Phase 3
9 Concomitant Utilization of Radio Frequency Energy for Atrial Fibrillation (CURE-AF) Study Completed NCT00431834 Phase 3
10 Cardiox Shunt Detection Technology Study Terminated NCT01333761 Phase 3
11 Right to Left Cardiac Shunt Detection Terminated NCT01773252 Phase 3
12 ESCAPE Migraine Trial Terminated NCT00267371 Phase 3 Medical management/current medications per standard of care by personal physician.
13 Premium Migraine Trial Completed NCT00355056 Phase 2
14 Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt Completed NCT00442364 Phase 2 Polidocanol (1%) Microfoam (Varisolve)
15 Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches Recruiting NCT02777359 Phase 2
16 Penumbral Rescue by Normobaric O2 Administration in Patients With Ischemic Stroke and Target Mismatch ProFile Not yet recruiting NCT03500939 Phase 2 Medical oxygen
17 PRIMA PFO Migraine Trial Terminated NCT00505570 Phase 2
18 Catheter Thrombectomy in Patients With Massive Pulmonary Embolism Terminated NCT00314002 Phase 1, Phase 2
19 Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli Withdrawn NCT02378623 Phase 2 Apixaban;Placebo
20 PFO Closure for Obstructive Sleep Apnoea Unknown status NCT02771561 Not Applicable
21 Influence of Position on Detection of Patent Foramen Ovale by Simultaneous Transesophageal Echo and Transcranial Doppler Unknown status NCT02383836
22 Timing of Closure of Patent Foramen Ovale Following Birth Unknown status NCT01032785
23 Prospective Clinical Follow-up After the Percutaneous Closure of a Patent Foramen Ovale Unknown status NCT01149447
24 Occluder Size Determination in Transcatheter ASD II Closure Based on 3D TEE Assessment Unknown status NCT02601768
25 Paradigm I Clinical Trial: Study of the PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemia Attack or Paradoxical Embolism Unknown status NCT00196027 Not Applicable
26 InterSEPT: In‐Tunnel SeptRx European PFO Trial Unknown status NCT01385670 Not Applicable
27 International Registry for ASD Closure by Using the Occlutech®Flex II Device in More Than 2000 Patients Unknown status NCT02766569
28 The Effect on EPCs by Successful Cardiac Occlusion Device Implantation Unknown status NCT02957201 Not Applicable
29 Clinical Proteomic Research for the Brain Unknown status NCT00983723
30 Quantitative End Tidal CO2 Monitoring in the Delivery Room (DR) Unknown status NCT01381068 Not Applicable
31 Comorbidities Associated With Migraine and Patent Foramen Ovale (CAMP) Completed NCT01257880
32 Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale Completed NCT01216423
33 Residual Shunt After Patent Foramen Ovale Device Closure in Patients With Cryptogenic Stroke Completed NCT03416426
34 Post Market Clinical Follow-up Study of IrisFITTM PFO (Patent Foramen Ovale) Occluder Completed NCT02882815 Not Applicable
35 Effectiveness and Safety of Transcatheter Patent Foramen Ovale Closure for Migraine Completed NCT02127294 Not Applicable
36 Safety and Effectiveness Study of the Solysafe Septal Occluder in Patients With Atrial Septum Defect and Patent Foramen Ovale Completed NCT00207376 Not Applicable
37 Risk of Stroke in Pulmonary Embolism With a Patent Foramen Ovale (PFO) Completed NCT00831259
38 Patent Foramen Ovale and the Risk of Postoperative Delirium Following Elective Hip and Knee Arthroplasty Surgeries Completed NCT02400892
39 Nitrogen Bubble Detection After Simulated Dives in Divers With PFO and After PFO Closure Completed NCT01854281
40 Impact Of Closure Of Patent Foramen Ovale On Apnoea-Hypopnoea-Index, Nocturnal Hypoxemia And Systemic Vascular Function In Patients With Obstructive Sleep Apnoea Completed NCT01780207 Not Applicable
41 Patent Foramen Ovale Closure or Medical Therapy After Stroke - RESPECT Trial Completed NCT00465270 Not Applicable
42 Patent Foramen Ovale in Children With Migraine Headaches Completed NCT00750594
43 Procedural Success and Safety of the Nit-Occlud® Patent Foramen Ovale (PFO) Closure Device and Its Application System Completed NCT00968032 Not Applicable
44 FIH Study With CBSO Completed NCT01960491 Not Applicable
45 GORE® Septal Occluder European Union Clinical Evaluation Completed NCT01605851 Not Applicable
46 Correlation of Right-left Shunt Detection in Cardioembolism Etiology in Stroke Patient. Completed NCT02351076
47 Cardiac Troponin T After Transcatheter Closure of the Interatrial Septum Completed NCT03099967
48 Long-term Safety Study of the GORE® HELEX® Septal Occluder Completed NCT00581308 Not Applicable
49 Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis Completed NCT03377465 Not Applicable
50 The Paradigm II Trial: PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemic Attack, Migraine or Decompression Illness Completed NCT00196040 Not Applicable

Search NIH Clinical Center for Patent Foramen Ovale

Cochrane evidence based reviews: foramen ovale, patent

Sources

Genetic Tests for Patent Foramen Ovale

About this section

Genetic tests related to Patent Foramen Ovale:

# Genetic test Affiliating Genes
1 Patent Foramen Ovale 29
Sources

Anatomical Context for Patent Foramen Ovale

About this section

MalaCards organs/tissues related to Patent Foramen Ovale:

41
Heart, Brain, Lung, Testes, Liver, Spinal Cord, Kidney
Sources

Publications for Patent Foramen Ovale

About this section

Articles related to Patent Foramen Ovale:

(show top 50) (show all 1256)
# Title Authors Year
1
Patent Foramen Ovale and Hypoxemia. ( 29570476 )
2019
2
Cerebral infarction following cyanoacrylate endoscopic therapy of duodenal varices in a patient with a patent foramen ovale. ( 29948836 )
2018
3
Intracardiac echocardiography for percutaneous patent foramen ovale and atrial septal defect occlusion. ( 29374291 )
2018
4
Adding patent foramen ovale closure to antiplatelet drugs reduced ischemic stroke after cryptogenic stroke. ( 29335718 )
2018
5
Paradoxical emboli following a pulmonary embolus in the presence of a patent foramen ovale. ( 29404367 )
2018
6
Patent foramen ovale closure versus medical therapy in cases with cryptogenic stroke, meta-analysis of randomized controlled trials. ( 29356972 )
2018
7
Closure of patent foramen ovale for cryptogenic stroke patients: an updated systematic review and meta-analysis of randomized trials. ( 29383514 )
2018
8
Quality of life after percutaneous closure of patent foramen ovale in patients after cryptogenic stroke compared to a normative sample. ( 29422265 )
2018
9
Meta-analysis of randomized trials on percutaneous patent foramen ovale closure for prevention of migraine. ( 29914296 )
2018
10
Multiple Cerebral Infarctions Due to Patent Foramen Ovale in a Patient with Eosinophilic Granulomatosis with Polyangiitis. ( 29373226 )
2018
11
A Novel ATP1A2 Gene Variant Associated With Pure Sporadic Hemiplegic Migraine Improved After Patent Foramen Ovale Closure: A Case Report. ( 29867740 )
2018
12
Odyssey of Patent Foramen Ovale: Closure in Cryptogenic Stroke: The Canary in the Coal Mine of Clinical Trials? ( 29910194 )
2018
13
Patent foramen ovale closure vs. medical therapy for recurrent stroke prevention: Evolution of treatment effect during follow-up. ( 29338916 )
2018
14
Biventricular Noncompaction Cardiomyopathy Accompanied by Severe Pulmonary Valvular Stenosis and Patent Foramen Ovale. ( 29911014 )
2018
15
The use of point-of-care ultrasound to diagnose patent foramen ovale in elective hip and knee arthroplasty patients and its association with postoperative delirium. ( 29368313 )
2018
16
A rare case of paradoxical embolism from tricuspid valve infective endocarditis and patent foramen ovale. ( 29372516 )
2018
17
Closure, Anticoagulation, or Antiplatelet Therapy for Cryptogenic Stroke With Patent Foramen Ovale: Systematic Review of Randomized Trials, Sequential Meta-Analysis, and New Insights From the CLOSE Study. ( 29910193 )
2018
18
Patent Foramen Ovale Closure for Stroke Prevention and Other Disorders. ( 29910192 )
2018
19
Is Patent Foramen Ovale a Risk Factor for Perioperative Stroke? ( 29411017 )
2018
20
A young woman with a symptomatic patent foramen ovale: Natasha's fascinating story. ( 29904322 )
2018
21
Net clinical benefit of patent foramen ovale closure in patients with cryptogenic stroke: Meta-analysis and meta-regression of randomized trials. ( 29887476 )
2018
22
Adding patent foramen ovale closure to antiplatelet therapy reduced stroke after cryptogenic stroke. ( 29335719 )
2018
23
Closure of Patent Foramen Ovale Versus Medical Therapy in Patients With Cryptogenic Stroke or Transient Ischemic Attack: Updated Systematic Review and Meta-Analysis. ( 29335335 )
2018
24
Patent foramen ovale in older patients with cryptogenic stroke or transient ischaemic attack. ( 29887163 )
2018
25
Tissue Plasminogen Activator to Treat a Stroke after Foam Sclerotherapy in a Woman with a Patent Foramen Ovale. ( 29402614 )
2018
26
Patent foramen ovale after cryptogenic stroke: When is it justifiable to close it? ( 29887477 )
2018
27
Novel Association of Juvenile Polyposis Syndrome With Atrial Septal Aneurysm and Patent Foramen Ovale: A Case Report. ( 29634562 )
2018
28
Patent foramen ovale closure for patients excluded from the randomized cryptogenic stroke trials. ( 29955915 )
2018
29
Patent foramen ovale and migraine with aura in a retrospective analysis: age matters. ( 29904837 )
2018
30
Patent Foramen Ovale and Risk of Perioperative Stroke-Reply. ( 29946721 )
2018
31
Patent Foramen Ovale Repair at the Time of Double Lung Transplantation: Necessary or Not? ( 29349838 )
2018
32
Patent Foramen Ovale and Risk of Perioperative Stroke. ( 29946718 )
2018
33
Very late migration to and retrieval of an Amplatzer patent foramen ovale occlusion device from the abdominal aortic carrefour. ( 29894354 )
2018
34
Association of Preoperatively Diagnosed Patent Foramen Ovale With Perioperative Ischemic Stroke. ( 29411032 )
2018
35
Closure of the patent foramen ovale, if only a stitch in time saved nine. ( 29893689 )
2018
36
Prevalence of patent foramen ovale in cryptogenic transient ischaemic attack and non-disabling stroke at older ages: a population-based study, systematic review, and meta-analysis. ( 29887162 )
2018
37
Long-term effectiveness and safety of transcatheter closure of patent foramen ovale compared with antithrombotic therapy: A meta-analysis of 6 randomised clinical trials and 3560 patients with reconstructed time-to-event data. ( 29901447 )
2018
38
New-onset atrial fibrillation following percutaneous patent foramen ovale closure: A systematic review and meta-analysis of randomised trials. ( 30327284 )
2018
39
Patent foramen ovale and atrial fibrillation as causes of cryptogenic stroke: is treatment with surgery superior to device closure and anticoagulation? A review of the literature. ( 30159163 )
2018
40
Thrombus "Squeezing" Through Patent Foramen Ovale After Traumatic Brain Injury. ( 30446933 )
2018
41
Patent foramen ovale with an enormous right-to-left shunt: unusual reversible cause of hypoxia in carcinoid syndrome. ( 30184060 )
2018
42
Infective Endocarditis of Patent Foramen Ovale Closure Device Presenting as an Amoeboid-Like Mass. ( 30391388 )
2018
43
Hypoxemia from patent foramen ovale in a 65-year-old woman with carcinoid heart disease. ( 30087129 )
2018
44
Ventilatory responses to acute hypoxia and hypercapnia in humans with a patent foramen ovale. ( 30521423 )
2018
45
Percutaneous closure of patent foramen ovale for paradoxical embolism in acute limb ischemia. ( 30109674 )
2018
46
May-Thurner Syndrome as a Rare Cause of Paradoxical Embolism in a Patient with Patent Foramen Ovale. ( 30057826 )
2018
47
Patent Foramen Ovale in Cryptogenic Stroke and Migraine with Aura: Does Size Matter? ( 30405989 )
2018
48
Concomitant acute stroke, pulmonary and myocardial infarction due to in-transient thrombus across a patent foramen ovale ( 30304635 )
2018
49
Concomitant acute stroke, pulmonary and myocardial infarction due to in-transient thrombus across a patent foramen ovale. ( 30099387 )
2018
50
A Positive Bubble Test Post-Patent Foramen Ovale Closure: Was Satisfaction-of-Search to Blame? ( 29880107 )
2018
Sources

Variations for Patent Foramen Ovale

About this section

ClinVar genetic disease variations for Patent Foramen Ovale:

6 (show all 14)
# Gene Variation Type Significance SNP ID Assembly Location
1 PTPN11 NM_002834.4(PTPN11): c.184T> G (p.Tyr62Asp) single nucleotide variant Pathogenic rs121918460 GRCh37 Chromosome 12, 112888168: 112888168
2 PTPN11 NM_002834.4(PTPN11): c.184T> G (p.Tyr62Asp) single nucleotide variant Pathogenic rs121918460 GRCh38 Chromosome 12, 112450364: 112450364
3 AAR2 NM_015511.4(AAR2): c.520G> A (p.Val174Met) single nucleotide variant Likely pathogenic rs746800707 GRCh38 Chromosome 20, 36240388: 36240388
4 AAR2 NM_015511.4(AAR2): c.520G> A (p.Val174Met) single nucleotide variant Likely pathogenic rs746800707 GRCh37 Chromosome 20, 34828310: 34828310
5 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh37 Chromosome 6, 149700090: 149700090
6 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh38 Chromosome 6, 149378954: 149378954
7 TRPM4 NM_017636.3(TRPM4): c.1376G> A (p.Arg459His) single nucleotide variant Conflicting interpretations of pathogenicity rs142312281 GRCh38 Chromosome 19, 49182690: 49182690
8 TRPM4 NM_017636.3(TRPM4): c.1376G> A (p.Arg459His) single nucleotide variant Conflicting interpretations of pathogenicity rs142312281 GRCh37 Chromosome 19, 49685947: 49685947
9 TBX5 NM_000192.3(TBX5): c.1221C> G (p.Tyr407Ter) single nucleotide variant Pathogenic GRCh38 Chromosome 12, 114355868: 114355868
10 TBX5 NM_000192.3(TBX5): c.1221C> G (p.Tyr407Ter) single nucleotide variant Pathogenic GRCh37 Chromosome 12, 114793673: 114793673
11 PKD1 NM_001009944.2(PKD1): c.226C> T (p.His76Tyr) single nucleotide variant Uncertain significance rs932577597 GRCh38 Chromosome 16, 2119368: 2119368
12 PKD1 NM_001009944.2(PKD1): c.226C> T (p.His76Tyr) single nucleotide variant Uncertain significance rs932577597 GRCh37 Chromosome 16, 2169369: 2169369
13 RNF213 NM_001256071.2(RNF213): c.11659A> G (p.Lys3887Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome 17, 80363699: 80363699
14 RNF213 NM_001256071.2(RNF213): c.11659A> G (p.Lys3887Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome 17, 78337499: 78337499
Sources

Expression for Patent Foramen Ovale

About this section
Search GEO for disease gene expression data for Patent Foramen Ovale.
Sources

Pathways for Patent Foramen Ovale

About this section

Pathways related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.94 APOH F12 F2 F5 GATA4 GATA6
2
Collagen chain trimerization 66
Show member pathways
 12.52 F12 F2 F5 SERPINC1 TLL1
3
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 11.87 F12 F2 F5 SERPINC1
4
Complement and coagulation cascades 1 37
11.77 F12 F2 F5 SERPINC1
5
Thyroid hormone signaling pathway 37
11.67 GATA4 MED13L MYH6
6
Cardiac Progenitor Differentiation 1
11.16 ACTC1 GATA4 MYH6 NKX2-5 TBX20 TBX5
7
Heart Development 1
10.76 GATA4 GATA6 NKX2-5 PTPN11 TBX20 TBX5
8
HOP Signaling 64
10.11 ACTC1 GATA4 NKX2-5
Sources

GO Terms for Patent Foramen Ovale

About this section

Biological processes related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.96 ACTC1 GATA4 GATA6 MTHFR
2 cellular protein metabolic process GO:0044267 9.91 F2 F5 GATA6 SERPINC1
3 heart development GO:0007507 9.85 CITED2 GATA4 GATA6 NKX2-5 PTPN11 TBX5
4 male gonad development GO:0008584 9.82 CITED2 GATA4 GATA6
5 blood coagulation GO:0007596 9.8 F12 F2 F5 GATA4 GATA6 SERPINC1
6 outflow tract morphogenesis GO:0003151 9.77 CITED2 NKX2-5 TBX20
7 cardiac muscle contraction GO:0060048 9.76 ACTC1 MYH6 NKX2-5
8 blood circulation GO:0008015 9.74 F5 MTHFR TBX20
9 positive regulation of cardiac muscle cell proliferation GO:0060045 9.73 GATA6 TBX20 TBX5
10 heart looping GO:0001947 9.73 CITED2 GATA4 NKX2-5 TBX20
11 ventricular septum development GO:0003281 9.71 CITED2 GATA4 TBX5
12 hemostasis GO:0007599 9.71 F12 F2 F5 SERPINC1
13 outflow tract septum morphogenesis GO:0003148 9.7 GATA6 NKX2-5 TBX20
14 cardiac muscle tissue morphogenesis GO:0055008 9.69 ACTC1 NKX2-5 TBX20
15 blood coagulation, intrinsic pathway GO:0007597 9.67 APOH F12 F2
16 actin filament-based movement GO:0030048 9.66 ACTC1 MYH6
17 embryonic heart tube development GO:0035050 9.66 NKX2-5 TBX20
18 cardiac muscle tissue development GO:0048738 9.65 GATA6 NKX2-5
19 endocardial cushion development GO:0003197 9.65 CITED2 GATA4 TBX5
20 adult heart development GO:0007512 9.64 MYH6 NKX2-5
21 cardiac muscle hypertrophy in response to stress GO:0014898 9.64 GATA6 MYH6
22 heart contraction GO:0060047 9.63 ACTC1 NKX2-5
23 cardiac right ventricle morphogenesis GO:0003215 9.63 GATA4 TBX20
24 positive regulation of blood coagulation GO:0030194 9.63 APOH F12 F2
25 cardiac ventricle morphogenesis GO:0003208 9.62 GATA4 NKX2-5
26 negative regulation of fibrinolysis GO:0051918 9.62 APOH F2
27 intestinal epithelial cell differentiation GO:0060575 9.61 GATA4 GATA6
28 embryonic heart tube left/right pattern formation GO:0060971 9.58 CITED2 NKX2-5
29 cardiac muscle cell differentiation GO:0055007 9.56 GATA4 GATA6 NKX2-5 TBX5
30 bundle of His development GO:0003166 9.55 NKX2-5 TBX5
31 atrial septum morphogenesis GO:0060413 9.46 GATA4 NKX2-5 TBX20 TBX5
32 regulation of blood coagulation GO:0030193 9.26 APOH F12 F2 SERPINC1
33 positive regulation of cardioblast differentiation GO:0051891 8.92 GATA4 GATA6 NKX2-5 TBX5
34 positive regulation of transcription, DNA-templated GO:0045893 10.07 CITED2 GATA4 GATA6 NKX2-5 TBX20 TBX5

Molecular functions related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.46 GATA4 GATA6 NKX2-5 TBX20
2 DNA-binding transcription factor activity GO:0003700 9.43 CITED2 GATA4 GATA6 NKX2-5 TBX20 TBX5
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.02 GATA4 GATA6 NKX2-5 TBX20 TBX5
Sources

Sources for Patent Foramen Ovale

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....