PET
MCID: PTL001
MIFTS: 32

Patulous Eustachian Tube (PET)

Categories: Ear diseases, Oral diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Patulous Eustachian Tube

MalaCards integrated aliases for Patulous Eustachian Tube:

Name: Patulous Eustachian Tube 12 53 15 73
Pet 53

Classifications:



External Ids:

Disease Ontology 12 DOID:12358
ICD10 33 H69.0 H69.00
ICD9CM 35 381.7
SNOMED-CT 68 30280005
UMLS 73 C0155434

Summaries for Patulous Eustachian Tube

NIH Rare Diseases : 53 Patulous eustachian tube is a benign but symptomatically troubling condition in which the eustachian tube stays open most of the time. The eustachian tube is the tube that runs between the middle ear and throat and regulates the ear pressure around the ear drum. Under normal circumstances, it remains closed most of the time, opening only on occasion to equalize air pressure between the middle ear and the exterior environment. Major symptoms include distorted autophony (hearing one's own voice or breathing), echoing which may interfere with speech production, wave-like sounds, and a sensation of fullness in the ear. In severe cases, vertigo and hearing loss may occur. Over time, individuals with patulous eustachian tube may develop serious and even extreme responses to the abnormal sounds and other findings. In most cases, the cause of patulous eustachian tube is unknown. Weight loss and pregnancy may be predisposing factors. Neurologic disorders that cause muscle atrophy such as stroke, multiple sclerosis, and motor neuron disease have been implicated in some cases of patulous eustachian tube. Other cases may be associated with medications such as oral contraceptives or diuretics. Other predisposing factors include fatigue, stress, anxiety, exercise, and temporomandibular joint syndrome. Many treatments have been proposed, however none have shown consistent effectiveness.

MalaCards based summary : Patulous Eustachian Tube, also known as pet, is related to intracranial hypotension and spontaneous intracranial hypotension. An important gene associated with Patulous Eustachian Tube is PGRMC1 (Progesterone Receptor Membrane Component 1). The drugs Triamcinolone and Triamcinolone hexacetonide have been mentioned in the context of this disorder. Affiliated tissues include prostate, brain and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A eustachian tube disorder with a wider eustachian tube which allows a larger bolus of bacteria-laden material from the nasopharynx during an infection to enter the middle ear, causing a more fulminant infection.

Wikipedia : 76 Patulous Eustachian tube, also known as patent Eustachian tube or PET, is the name of a physical... more...

Related Diseases for Patulous Eustachian Tube

Graphical network of the top 20 diseases related to Patulous Eustachian Tube:



Diseases related to Patulous Eustachian Tube

Symptoms & Phenotypes for Patulous Eustachian Tube

GenomeRNAi Phenotypes related to Patulous Eustachian Tube according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 CANX
2 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.53 CDK9
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.53 CANX CDK9
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.53 CANX
5 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.53 CDK9
6 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.53 CDK9
7 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.53 CANX
8 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.53 CDK9
9 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.53 CANX
10 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.53 CDK9
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.53 CDK9
12 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.53 CANX
13 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.53 CDK9
14 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.53 CANX
15 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.53 CANX
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.43 CANX CDK9
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.43 CANX
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.43 CDK9
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.43 CDK9
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.43 CDK9

Drugs & Therapeutics for Patulous Eustachian Tube

Drugs for Patulous Eustachian Tube (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved 124-94-7 31307
2 Triamcinolone hexacetonide
3 triamcinolone acetonide
4 Triamcinolone diacetate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Clay Weight on the Ear Drum for Patulous Eustachian Tube Unknown status NCT00933478
2 Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults Completed NCT01251432

Search NIH Clinical Center for Patulous Eustachian Tube

Genetic Tests for Patulous Eustachian Tube

Anatomical Context for Patulous Eustachian Tube

MalaCards organs/tissues related to Patulous Eustachian Tube:

41
Prostate, Brain, Lung, Bone, Lymph Node, Liver, Thyroid

Publications for Patulous Eustachian Tube

Articles related to Patulous Eustachian Tube:

(show top 50) (show all 1106)
# Title Authors Year
1
Pretreatment quantitative 18F-FDG PET/CT parameters as a predictor of survival in adenoid cystic carcinoma of the salivary glands. ( 30308429 )
2019
2
68Ga-PSMA Uptake in Anal Fistula on PET/CT Scan. ( 30540600 )
2019
3
The Prognostic Value of 18F-FDG Uptake in the Supraclavicular Lymph Node (N3c) on PET/CT in Patients With Locally Advanced Breast Cancer With Clinical N3c. ( 30540598 )
2019
4
Prognostic role of baseline 18F-FDG PET/CT metabolic parameters in Burkitt lymphoma. ( 30276438 )
2019
5
Hypoxia imaging with [18F]HX4 PET in squamous cell head and neck cancers: a pilot study for integration into treatment planning. ( 30371605 )
2019
6
FDG PET in response evaluation of bulky masses in paediatric Hodgkin's lymphoma (HL) patients enrolled in the Italian AIEOP-LH2004 trial. ( 30219963 )
2019
7
Evolving Role of PET/CT-MRI in Assessing Muscle Disorders. ( 30420223 )
2019
8
Imaging of Osteoarthritis by Conventional Radiography, MR Imaging, PET-Computed Tomography, and PET-MR Imaging. ( 30420217 )
2019
9
Evolving Role of MR Imaging and PET in Assessing Osteoporosis. ( 30420220 )
2019
10
68Ga-PSMA PET/CT Urachus Metastases in Recurrent Prostate Cancer With Very Low PSA Level. ( 30540597 )
2019
11
Effect of positive carbon-11-choline PET/CT results in the therapeutic management of prostate cancer biochemical relapse. ( 30521498 )
2019
12
Can SUVmax values of Ga-68-PSMA PET/CT scan predict the clinically significant prostate cancer? ( 30395048 )
2019
13
68Ga-PSMA-11 PET/CT in recurrent prostate cancer: efficacy in different clinical stages of PSA failure after radical therapy. ( 30350010 )
2019
14
Pituitary 18F-FDG uptake correlates with serum TSH levels in thyroid cancer patients on 18F-FDG PET/CT. ( 30422898 )
2019
15
18F-FDG PET/CT is useful for determining survival outcomes of patients with multiple myeloma classified as stage II and III with the Revised International Staging System. ( 30187105 )
2019
16
MR Imaging of the Urinary Bladder: Added Value of PET-MR Imaging. ( 30466905 )
2019
17
A prospective study of the feasibility of FDG-PET/CT imaging to quantify radiation-induced lung inflammation in locally advanced non-small cell lung cancer patients receiving proton or photon radiotherapy. ( 30229527 )
2019
18
PET/CT Lung Ventilation and Perfusion Scanning using Galligas and Gallium-68-MAA. ( 30545520 )
2019
19
Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide. ( 30408634 )
2019
20
Applications of PET-Computed Tomography-Magnetic Resonance in the Management of Benign Musculoskeletal Disorders. ( 30420212 )
2019
21
Skeletal Metastasis Evaluation: Value and Impact of PET/Computed Tomography on Diagnosis, Management and Prognosis. ( 30420213 )
2019
22
Hybrid Imaging (PET-Computed Tomography/PET-MR Imaging) of Bone Metastases. ( 30420214 )
2019
23
Pediatric Musculoskeletal Imaging: The Indications for and Applications of PET/Computed Tomography. ( 30420216 )
2019
24
Hot Topics of Research in Musculoskeletal Imaging: PET/MR Imaging, MR Fingerprinting, Dual-energy CT Scan, Ultrashort Echo Time. ( 30420218 )
2019
25
PET Imaging of Peripheral Nerve Tumors. ( 30420224 )
2019
26
Management of Primary Osseous Spinal Tumors with PET. ( 30420225 )
2019
27
PET-Computed Tomography and PET-MR Imaging and Their Applications in the Twenty-First Century. ( 30420226 )
2019
28
Comparative immuno-Cerenkov luminescence and -PET imaging enables detection of PSMA+ tumors in mice using 64Cu-radiolabeled monoclonal antibodies. ( 30445280 )
2019
29
Disease quantification on PET/CT images without explicit object delineation. ( 30453165 )
2019
30
A versatile signal-enhanced ECL sensing platform based on molecular imprinting technique via PET-RAFT cross-linking polymerization using bifunctional ruthenium complex as both catalyst and sensing probes. ( 30339974 )
2019
31
Role of FDG PET/CT in monitoring treatment response in patients with invasive fungal infections. ( 30343434 )
2019
32
Effect of blood glucose level on standardized uptake value (SUV) in 18F- FDG PET-scan: a systematic review and meta-analysis of 20,807 individual SUV measurements. ( 30350009 )
2019
33
Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer. ( 30362376 )
2019
34
Cross-section measurement of 44mSc,47Sc, 48Sc and 47Ca for an optimized 47Sc production with an 18 MeV medical PET cyclotron. ( 30368048 )
2019
35
Imaging phosphodiesterase-10a availability in cocaine use disorder with [11 C]IMA107 and PET. ( 30240027 )
2019
36
FDG-PET imaging to detect and characterize underlying causes of fever of unknown origin: an unavoidable path for the foreseeable future. ( 30242428 )
2019
37
Salvage extended field or involved field nodal irradiation in 18F-fluorocholine PET/CT oligorecurrent nodal failures from prostate cancer. ( 30267117 )
2019
38
Practice-based evidence for the clinical benefit of PET/CT-results of the first oncologic PET/CT registry in Germany. ( 30269155 )
2019
39
Automated quantification of reference levels in liver and mediastinal blood pool for the Deauville therapy response classification using FDG-PET/CT in Hodgkin and non-Hodgkin lymphomas. ( 30284376 )
2019
40
Real-Time US-18FDG-PET/CT Image Fusion for Guidance of Thermal Ablation of 18FDG-PET-Positive Liver Metastases: The Added Value of Contrast Enhancement. ( 30288593 )
2019
41
FDG PET/CT for assessing tumour response to immunotherapy : Report on the EANM symposium on immune modulation and recent review of the literature. ( 30291373 )
2019
42
Joint Tumor Segmentation in PET-CT Images Using Co-Clustering and Fusion Based on Belief Functions. ( 30296224 )
2019
43
Imaging glutamate redistribution after acute N-acetylcysteine administration: A simultaneous PET/MR study. ( 30296554 )
2019
44
High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain. ( 30300753 )
2019
45
Diagnostic and prognostic value of 18F-FDG PET/CT imaging in suspected recurrence of male breast cancer. ( 30312217 )
2019
46
Contribution of PET imaging to mortality risk stratification in candidates to lead extraction for pacemaker or defibrillator infection: a prospective single center study. ( 30196365 )
2019
47
Improved specificity with 68Ga PSMA PET/CT to detect clinically significant lesions "invisible" on multiparametric MRI of the prostate: a single institution comparative analysis with radical prostatectomy histology. ( 30229528 )
2019
48
Patulous Eustachian tube obliteration using endovascular coils: a novel technique. ( 29888685 )
2018
49
Diagnostic criteria for Patulous Eustachian Tube: A proposal by the Japan Otological Society. ( 29153260 )
2018
50
Trans-tympanic Cartilage Chip Insertion for Intractable Patulous Eustachian Tube. ( 29719947 )
2018

Variations for Patulous Eustachian Tube

Expression for Patulous Eustachian Tube

Search GEO for disease gene expression data for Patulous Eustachian Tube.

Pathways for Patulous Eustachian Tube

GO Terms for Patulous Eustachian Tube

Cellular components related to Patulous Eustachian Tube according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.62 CANX PGRMC1

Sources for Patulous Eustachian Tube

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