MCID: PTL001
MIFTS: 27

Patulous Eustachian Tube

Categories: Rare diseases, Ear diseases

Aliases & Classifications for Patulous Eustachian Tube

MalaCards integrated aliases for Patulous Eustachian Tube:

Name: Patulous Eustachian Tube 12 53 15 73
Pet 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Ear diseases


External Ids:

Disease Ontology 12 DOID:12358
ICD10 33 H69.0 H69.00
ICD9CM 35 381.7
SNOMED-CT 68 30280005
UMLS 73 C0155434

Summaries for Patulous Eustachian Tube

NIH Rare Diseases : 53 Patulous eustachian tube is a benign but symptomatically troubling condition in which the eustachian tube stays open most of the time. The eustachian tube is the tube that runs between the middle ear and throat and regulates the ear pressure around the ear drum. Under normal circumstances, it remains closed most of the time, opening only on occasion to equalize air pressure between the middle ear and the exterior environment. Major symptoms include distorted autophony (hearing one's own voice or breathing), echoing which may interfere with speech production, wave-like sounds, and a sensation of fullness in the ear. In severe cases, vertigo and hearing loss may occur. Over time, individuals with patulous eustachian tube may develop serious and even extreme responses to the abnormal sounds and other findings. In most cases, the cause of patulous eustachian tube is unknown. Weight loss and pregnancy may be predisposing factors. Neurologic disorders that cause muscle atrophy such as stroke, multiple sclerosis, and motor neuron disease have been implicated in some cases of patulous eustachian tube. Other cases may be associated with medications such as oral contraceptives or diuretics. Other predisposing factors include fatigue, stress, anxiety, exercise, and temporomandibular joint syndrome. Many treatments have been proposed, however none have shown consistent effectiveness.

MalaCards based summary : Patulous Eustachian Tube, also known as pet, is related to intracranial hypotension and spontaneous intracranial hypotension. An important gene associated with Patulous Eustachian Tube is PGRMC1 (Progesterone Receptor Membrane Component 1). The drugs Triamcinolone and triamcinolone acetonide have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A eustachian tube disorder with a wider eustachian tube which allows a larger bolus of bacteria-laden material from the nasopharynx during an infection to enter the middle ear, causing a more fulminant infection.

Wikipedia : 76 Patulous Eustachian tube, also known as patent Eustachian tube or PET, is the name of a physical... more...

Related Diseases for Patulous Eustachian Tube

Graphical network of the top 20 diseases related to Patulous Eustachian Tube:



Diseases related to Patulous Eustachian Tube

Symptoms & Phenotypes for Patulous Eustachian Tube

GenomeRNAi Phenotypes related to Patulous Eustachian Tube according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.88 CANX
2 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.88 CDK9
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.88 CANX CDK9
4 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.88 CANX CDK9
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.88 CANX
6 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.88 CDK9
7 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.88 CDK9
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.88 CANX
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.88 CDK9
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.88 CANX
11 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.88 CDK9
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.88 CDK9
13 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.88 CANX
14 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.88 CDK9
15 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.88 CANX
16 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.88 CANX

Drugs & Therapeutics for Patulous Eustachian Tube

Drugs for Patulous Eustachian Tube (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved 124-94-7 31307
2 triamcinolone acetonide
3 Triamcinolone diacetate
4 Triamcinolone hexacetonide

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Clay Weight on the Ear Drum for Patulous Eustachian Tube Unknown status NCT00933478
2 Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults Completed NCT01251432

Search NIH Clinical Center for Patulous Eustachian Tube

Genetic Tests for Patulous Eustachian Tube

Anatomical Context for Patulous Eustachian Tube

MalaCards organs/tissues related to Patulous Eustachian Tube:

41
Testes

Publications for Patulous Eustachian Tube

Articles related to Patulous Eustachian Tube:

(show top 50) (show all 101)
# Title Authors Year
1
Patulous Eustachian tube obliteration using endovascular coils: a novel technique. ( 29888685 )
2018
2
Diagnostic criteria for Patulous Eustachian Tube: A proposal by the Japan Otological Society. ( 29153260 )
2018
3
Trans-tympanic Cartilage Chip Insertion for Intractable Patulous Eustachian Tube. ( 29719947 )
2018
4
Patulous Eustachian Tube Dysfunction: Patient Demographics and Comorbidities. ( 28796094 )
2017
5
How to treat a patulous Eustachian tube. ( 28545661 )
2017
6
Transmission of a novel sonotubometry acoustic click stimulus in healthy and patulous eustachian tube subjects: a retrospective case -control study. ( 28619119 )
2017
7
Patulous Eustachian Tube and Otitis Media With Effusion as Complications After Trigeminal Nerve Injury. ( 28708793 )
2017
8
Sonotubometric Assessment for Severity of Patulous Eustachian Tube. ( 28437362 )
2017
9
The efficacy of the Eustachian Tube Dysfunction Questionnaire (ETDQ-7) for patulous Eustachian tube patient. ( 28880712 )
2017
10
New Scoring System for Evaluating Patulous Eustachian Tube Patients. ( 28306653 )
2017
11
Endoscope-assisted silicone plug insertion for patulous Eustachian tube patients. ( 28233914 )
2017
12
Full-thickness cartilage myringoplasty on the patulous Eustachian tube. ( 28386645 )
2017
13
Relationship Between Clinical Test Results and Morphologic Severity Demonstrated by Sitting 3-D CT in Patients With Patulous Eustachian Tube. ( 27273397 )
2016
14
Effectiveness of Kobayashi plug for 252 ears with chronic patulous Eustachian tube. ( 27666086 )
2016
15
Computed tomography findings of the bony portion of the Eustachian tube with or without patulous Eustachian tube patients. ( 27838740 )
2016
16
Eardrum thickening approach for the treatment of patulous Eustachian tube. ( 27048519 )
2016
17
A case of patulous Eustachian tube associated with dizziness induced by nasal respiration. ( 27089972 )
2016
18
The effect of ventilation tube insertion or trans-tympanic silicone plug insertion on a patulous Eustachian tube. ( 26903085 )
2016
19
Endoscopic autologous cartilage injection for the patulous eustachian tube. ( 26954856 )
2016
20
Polydimethylsiloxane elastomer injection in the management of the patulous eustachian tube. ( 27515559 )
2016
21
Surgical management of Patulous eustachian tube: A systematic review. ( 25646902 )
2015
22
Treatment Effectiveness for Symptoms of Patulous Eustachian Tube: A Systematic Review. ( 26595716 )
2015
23
Trans-tympanic catheter insertion for treatment of patulous eustachian tube. ( 26545465 )
2015
24
Assessment of nasal-noise masking audiometry as a diagnostic test for patulous Eustachian tube. ( 25522198 )
2015
25
Tympanic membrane manipulation to treat symptoms of patulous eustachian tube. ( 25111423 )
2014
26
Treatment of the Patulous Eustachian Tube With Soft-Tissue Bulking Agent Injections. ( 25356764 )
2014
27
Patulous eustachian tube after percutaneous balloon microcompression for trigeminal neuralgia: case report. ( 24819466 )
2014
28
Endoscopic transnasal shim technique for treatment of patulous eustachian tube. ( 24913470 )
2014
29
Images in clinical medicine. Patulous eustachian tube causing hypermobile eardrums. ( 25517722 )
2014
30
Calcium hydroxylapatite injection for the patulous Eustachian tube. ( 24462522 )
2014
31
Endoscopic hydroxyapatite augmentation for patulous eustachian tube. ( 23775903 )
2014
32
Paper patching of the tympanic membrane as a symptomatic treatment for patulous eustachian tube syndrome. ( 24565065 )
2014
33
A novel, computed tomography guided, trans-cutaneous approach to treat refractory autophony in a patient with a patulous eustachian tube. ( 24467870 )
2014
34
Amantadine-induced patulous eustachian tubes in Parkinson's disease. ( 24349813 )
2013
35
Endoscopic ligation of the patulous eustachian tube as treatment for autophony. ( 23070705 )
2013
36
Movement of the Eustachian tube during sniffing in patients with patulous Eustachian tube: evaluation using a 320-row area detector CT scanner. ( 23303173 )
2013
37
Radiologic Confirmation of Patulous Eustachian Tube by Recumbent Computed Tomography. ( 24270710 )
2013
38
Uncommon aetiology for autophony: patulous eustachian tube. ( 22439921 )
2013
39
Autologous cartilage injection for the patulous eustachian tube. ( 20466454 )
2011
40
Curvature inversion technique: a novel tuboplastic technique for patulous Eustachian tube--a preliminary report. ( 21521901 )
2011
41
Management of patulous eustachian tube with habitual sniffing. ( 21659936 )
2011
42
Use of middle ear immittance testing in the evaluation of patulous eustachian tube. ( 21586254 )
2011
43
Patulous eustachian tube in bariatric surgery patients. ( 20869562 )
2010
44
Nasal instillation of physiological saline for patulous eustachian tube. ( 20082564 )
2010
45
Simple mass loading of the tympanic membrane to alleviate symptoms of patulous eustachian tube. ( 20470670 )
2010
46
Use of calcium hydroxylapatite for management of recalcitrant otorrhea due to a patulous eustachian tube. ( 21035198 )
2010
47
Roaring in the ears: patulous Eustachian tube in bulbar amyotrophic lateral sclerosis. ( 20192885 )
2010
48
Images in clinical medicine. Patulous eustachian tube and eustachian-tube dysfunction. ( 19458361 )
2009
49
Patulous eustachian tube complicating gastric bypass surgery. ( 19102815 )
2009
50
Three-dimensional computed tomography imaging of the eustachian tube lumen in patients with patulous eustachian tube. ( 20016242 )
2009

Variations for Patulous Eustachian Tube

Expression for Patulous Eustachian Tube

Search GEO for disease gene expression data for Patulous Eustachian Tube.

Pathways for Patulous Eustachian Tube

GO Terms for Patulous Eustachian Tube

Cellular components related to Patulous Eustachian Tube according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.62 CANX PGRMC1

Sources for Patulous Eustachian Tube

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
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28 GO
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30 HGMD
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32 HPO
33 ICD10
34 ICD10 via Orphanet
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49 NCI
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51 NDF-RT
54 NINDS
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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