PET
MCID: PTL001
MIFTS: 27

Patulous Eustachian Tube (PET)

Categories: Ear diseases, Oral diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Patulous Eustachian Tube

MalaCards integrated aliases for Patulous Eustachian Tube:

Name: Patulous Eustachian Tube 12 52 15 71 32
Pet 52

Classifications:



External Ids:

Disease Ontology 12 DOID:12358
ICD9CM 34 381.7
SNOMED-CT 67 30280005
ICD10 32 H69.0
UMLS 71 C0155434

Summaries for Patulous Eustachian Tube

NIH Rare Diseases : 52 Patulous eustachian tube is a benign but symptomatically troubling condition in which the eustachian tube stays open most of the time. The eustachian tube is the tube that runs between the middle ear and throat and regulates the ear pressure around the ear drum. Under normal circumstances, it remains closed most of the time, opening only on occasion to equalize air pressure between the middle ear and the exterior environment. Major symptoms include distorted autophony (hearing one's own voice or breathing), echoing which may interfere with speech production, wave-like sounds, and a sensation of fullness in the ear. In severe cases, vertigo and hearing loss may occur. Over time, individuals with patulous eustachian tube may develop serious and even extreme responses to the abnormal sounds and other findings. In most cases, the cause of patulous eustachian tube is unknown. Weight loss and pregnancy may be predisposing factors. Neurologic disorders that cause muscle atrophy such as stroke , multiple sclerosis , and motor neuron disease have been implicated in some cases of patulous eustachian tube. Other cases may be associated with medications such as oral contraceptives or diuretics . Other predisposing factors include fatigue, stress, anxiety, exercise, and temporomandibular joint syndrome . Many treatments have been proposed, however none have shown consistent effectiveness.

MalaCards based summary : Patulous Eustachian Tube, also known as pet, is related to otitis media and cholesteatoma of middle ear. An important gene associated with Patulous Eustachian Tube is SNORD79 (Small Nucleolar RNA, C/D Box 79). The drugs Triamcinolone and Triamcinolone diacetate have been mentioned in the context of this disorder. Affiliated tissues include testes and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A eustachian tube disorder with a wider eustachian tube which allows a larger bolus of bacteria-laden material from the nasopharynx during an infection to enter the middle ear, causing a more fulminant infection.

Wikipedia : 74 Patulous Eustachian tube (PET) is the name of a physical disorder where the Eustachian tube, which is... more...

Related Diseases for Patulous Eustachian Tube

Graphical network of the top 20 diseases related to Patulous Eustachian Tube:



Diseases related to Patulous Eustachian Tube

Symptoms & Phenotypes for Patulous Eustachian Tube

GenomeRNAi Phenotypes related to Patulous Eustachian Tube according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.4 SLC6A20
2 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.4 NR2F6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.4 SLC6A20
4 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.4 SLC6A20
5 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.4 NR2F6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-181 9.4 NR2F6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.4 SLC6A20
8 Increased shRNA abundance (Z-score > 2) GR00366-A-216 9.4 NR2F6
9 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.4 NR2F6 SLC6A20
10 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.4 NR2F6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.4 SLC6A20

Drugs & Therapeutics for Patulous Eustachian Tube

Drugs for Patulous Eustachian Tube (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved 124-94-7 31307
2 Triamcinolone diacetate
3 triamcinolone acetonide
4 Triamcinolone hexacetonide

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Clay Weight on the Ear Drum for Patulous Eustachian Tube Unknown status NCT00933478
2 Post Operative Quality of Life Assesment After Patulous Eustachian Tube Surgical Treatment Completed NCT04261946
3 Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults With Clinically Diagnosed Chronic Otitis Media With Effusion and/or Eustachian Tube Dysfunction Completed NCT01251432

Search NIH Clinical Center for Patulous Eustachian Tube

Genetic Tests for Patulous Eustachian Tube

Anatomical Context for Patulous Eustachian Tube

MalaCards organs/tissues related to Patulous Eustachian Tube:

40
Testes, Bone

Publications for Patulous Eustachian Tube

Articles related to Patulous Eustachian Tube:

(show top 50) (show all 176)
# Title Authors PMID Year
1
Treatment Effectiveness for Symptoms of Patulous Eustachian Tube: A Systematic Review. 61 52
26595716 2015
2
Patulous Eustachian tube and palatine defect in a Dachshund with chronic unilateral otitis externa and otitis media. 61
31908074 2020
3
Diagnostic approaches to and management options for patulous eustachian tube. 61
32518922 2020
4
Current Treatment Options for Patulous Eustachian Tube: A Review of the Literature. 61
32538676 2020
5
Comparison of patulous Eustachian tube patients with and without a concave defect in the anterolateral wall of the tubal valve. 61
32524919 2020
6
Efficacy of a silicone plug for patulous eustachian tube: A prospective, multicenter case series. 61
31400157 2020
7
Diagnosis of the Patulous Eustachian Tube. 61
32397811 2020
8
The usefulness of Valsalva computed tomography as an assessment tool for the Eustachian tube. 61
32354482 2020
9
Rhythmic Wave Patterns on Ambient Pressure Tympanometry in Patients With Objective Tinnitus-associated Pathologies. 61
31868782 2020
10
Flat-panel CT Imaging of a Radiopaque Shim for Patulous Eustachian Tube Dysfunction. 61
32040079 2020
11
Development of a rat model of patulous eustachian tube by mandibular nerve resection. 61
30910415 2019
12
Management of Acquired Cholesteatoma Associated With Patulous Eustachian Tube and Habitual Sniffing. 61
31066246 2019
13
Plug size selection protocol for the treatment of intractable patulous Eustachian tube with Kobayashi Plug. 61
31430219 2019
14
Otitis media with effusion in adults with patulous Eustachian tube. 61
31547745 2019
15
Patulous Eustachian tube (PET), a practical overview. 61
31750425 2019
16
Advances in Eustachian tube function testing. 61
31750424 2019
17
Surgical treatments for a case of superior canal dehiscence syndrome associated with patulous Eustachian tube. 61
30287116 2019
18
Comment on: Trans-Tympanic Cartilage Chip Insertion for Intractable Patulous Eustachian Tube. 61
31315393 2019
19
Changes of visualised Eustachian tube lengths by age and position: Radiologic study in sitting and supine positions using cone beam and conventional CT. 61
31004465 2019
20
Width of Patulous Eustachian Tube: Comparison of Assessment by Sonotubometry and Tubo-tympano-aerography. 61
30870363 2019
21
Rhinological interventions for sleep apnoea, patulous Eustachian tube and the demise of the tuning fork? 61
30983566 2019
22
A novel computed tomography guided, transcutaneous approach to treat refractory autophony in patients with a patulous Eustachian tube - a case series. 61
30789119 2019
23
Anatomy of the Surrounding Tissue of the Eustachian Tube in Patulous Eustachian Tube: 3 Tesla Magnetic Resonance Imaging Approach. 61
30570609 2019
24
Paper patching for patulous eustachian tube. 61
30762451 2019
25
Twelve-month outcomes of Eustachian tube procedures for management of patulous Eustachian tube dysfunction. 61
30325505 2019
26
The characteristic of patulous eustachian tube patients diagnosed by the JOS diagnostic criteria. 61
31881045 2019
27
Incidence of Functional Nasal Voice in Patients With Patulous Eustachian Tube. 61
30239429 2018
28
Saline injection to determine the volume required for personalised patulous Eustachian tube augmentation with long-standing material. 61
30322420 2018
29
Tinnitus. 61
30342610 2018
30
Prevalence and incidence of clinically significant patulous Eustachian tube: A population-based study using the Korean National Health Insurance Claims Database. 61
30025742 2018
31
Trans-tympanic Cartilage Chip Insertion for Intractable Patulous Eustachian Tube. 61
29719947 2018
32
[Progress in diagnosis of patulous eustachian tube]. 61
29921046 2018
33
Patulous Eustachian tube obliteration using endovascular coils: a novel technique. 61
29888685 2018
34
[Diagnosis and treatment of Eustachian tube dysfunction]. 61
29313115 2018
35
Diagnostic criteria for Patulous Eustachian Tube: A proposal by the Japan Otological Society. 61
29153260 2018
36
[Correlation between patulous Eustachian tube with habitual nasal extraction and acquired middle ear cholesteatoma]. 61
29429183 2018
37
[Submucosal injection of pharyngeal ostium of Eustachian tube for diagnosis of patulous Eustachian tube]. 61
29757555 2018
38
[The patulous Eustachian tube syndrome: the current state-of-the-art and an original clinical observation. Second communication]. 61
29953063 2018
39
The efficacy of the Eustachian Tube Dysfunction Questionnaire (ETDQ-7) for patulous Eustachian tube patient. 61
28880712 2018
40
[The patulous Eustachian tube syndrome: the current state of the problem and our own clinical observation. Part 1]. 61
29697658 2018
41
Author's reply to a letter-to-the-editor about the paper 'Eardrum thickening approach for the treatment of patulous Eustachian tube'. 61
28421277 2017
42
Full-thickness cartilage myringoplasty on the patulous Eustachian tube. 61
28386645 2017
43
Patulous Eustachian Tube Dysfunction: Patient Demographics and Comorbidities. 61
28796094 2017
44
Endoscope-assisted silicone plug insertion for patulous Eustachian tube patients. 61
28233914 2017
45
Patulous Eustachian Tube and Otitis Media With Effusion as Complications After Trigeminal Nerve Injury. 61
28708793 2017
46
How to treat a patulous Eustachian tube. 61
28545661 2017
47
Sonotubometric Assessment for Severity of Patulous Eustachian Tube. 61
28437362 2017
48
New Scoring System for Evaluating Patulous Eustachian Tube Patients. 61
28306653 2017
49
Transmission of a novel sonotubometry acoustic click stimulus in healthy and patulous eustachian tube subjects: a retrospective case -control study. 61
28619119 2017
50
Effectiveness of Kobayashi plug for 252 ears with chronic patulous Eustachian tube. 61
27666086 2017

Variations for Patulous Eustachian Tube

Expression for Patulous Eustachian Tube

Search GEO for disease gene expression data for Patulous Eustachian Tube.

Pathways for Patulous Eustachian Tube

GO Terms for Patulous Eustachian Tube

Sources for Patulous Eustachian Tube

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68 SNOMED-CT via HPO
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70 Tocris
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72 UMLS via Orphanet
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