MCID: PDG001
MIFTS: 14

Pdgfra-Associated Chronic Eosinophilic Leukemia

Categories: Cancer diseases, Immune diseases, Respiratory diseases

Aliases & Classifications for Pdgfra-Associated Chronic Eosinophilic Leukemia

MalaCards integrated aliases for Pdgfra-Associated Chronic Eosinophilic Leukemia:

Name: Pdgfra-Associated Chronic Eosinophilic Leukemia 43 70
Pdgfra-Associated Myeloproliferative Neoplasm 43

Classifications:



External Ids:

UMLS 70 C3853548

Summaries for Pdgfra-Associated Chronic Eosinophilic Leukemia

MedlinePlus Genetics : 43 PDGFRA-associated chronic eosinophilic leukemia is a form of blood cell cancer characterized by an elevated number of cells called eosinophils in the blood. These cells help fight infections by certain parasites and are involved in the inflammation associated with allergic reactions. However, these circumstances do not account for the increased number of eosinophils in PDGFRA-associated chronic eosinophilic leukemia.Another characteristic feature of PDGFRA-associated chronic eosinophilic leukemia is organ damage caused by the excess eosinophils. Eosinophils release substances to aid in the immune response, but the release of excessive amounts of these substances causes damage to one or more organs, most commonly the heart, skin, lungs, or nervous system. Eosinophil-associated organ damage can lead to a heart condition known as eosinophilic endomyocardial disease, skin rashes, coughing, difficulty breathing, swelling (edema) in the lower limbs, confusion, changes in behavior, or impaired movement or sensations. People with PDGFRA-associated chronic eosinophilic leukemia can also have an enlarged spleen (splenomegaly) and elevated levels of certain chemicals called vitamin B12 and tryptase in the blood.Some people with PDGFRA-associated chronic eosinophilic leukemia have an increased number of other types of white blood cells, such as neutrophils or mast cells. Occasionally, people with PDGFRA-associated chronic eosinophilic leukemia develop other blood cell cancers, such as acute myeloid leukemia or B-cell or T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma.PDGFRA-associated chronic eosinophilic leukemia is often grouped with a related condition called hypereosinophilic syndrome. These two conditions have very similar signs and symptoms; however, the cause of hypereosinophilic syndrome is unknown.

MalaCards based summary : Pdgfra-Associated Chronic Eosinophilic Leukemia, also known as pdgfra-associated myeloproliferative neoplasm, is related to chronic eosinophilic leukemia and hypereosinophilic syndrome. An important gene associated with Pdgfra-Associated Chronic Eosinophilic Leukemia is FIP1L1 (Factor Interacting With PAPOLA And CPSF1). Affiliated tissues include heart, spleen and myeloid.

Related Diseases for Pdgfra-Associated Chronic Eosinophilic Leukemia

Graphical network of the top 20 diseases related to Pdgfra-Associated Chronic Eosinophilic Leukemia:



Diseases related to Pdgfra-Associated Chronic Eosinophilic Leukemia

Symptoms & Phenotypes for Pdgfra-Associated Chronic Eosinophilic Leukemia

Drugs & Therapeutics for Pdgfra-Associated Chronic Eosinophilic Leukemia

Search Clinical Trials , NIH Clinical Center for Pdgfra-Associated Chronic Eosinophilic Leukemia

Genetic Tests for Pdgfra-Associated Chronic Eosinophilic Leukemia

Anatomical Context for Pdgfra-Associated Chronic Eosinophilic Leukemia

MalaCards organs/tissues related to Pdgfra-Associated Chronic Eosinophilic Leukemia:

40
Heart, Spleen, Myeloid

Publications for Pdgfra-Associated Chronic Eosinophilic Leukemia

Articles related to Pdgfra-Associated Chronic Eosinophilic Leukemia:

# Title Authors PMID Year
1
When Hypereosinophilia Leads to Stroke. 61
30755950 2017
2
Long-term outcomes of imatinib in patients with FIP1L1/ PDGFRA associated chronic eosinophilic leukemia: experience of a single center in China. 61
27120808 2016
3
The Spectrum of FIP1L1-PDGFRA-Associated Chronic Eosinophilic Leukemia: New Insights Based on a Survey of 44 Cases. 61
23982058 2013
4
Comparative proteomic analysis of blood eosinophils reveals redox signaling modifications in patients with FIP1L1-PDGFRA-associated chronic eosinophilic leukemia. 61
21302907 2011
5
KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities. 61
17628645 2007

Variations for Pdgfra-Associated Chronic Eosinophilic Leukemia

Expression for Pdgfra-Associated Chronic Eosinophilic Leukemia

Search GEO for disease gene expression data for Pdgfra-Associated Chronic Eosinophilic Leukemia.

Pathways for Pdgfra-Associated Chronic Eosinophilic Leukemia

GO Terms for Pdgfra-Associated Chronic Eosinophilic Leukemia

Sources for Pdgfra-Associated Chronic Eosinophilic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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