MCID: PDG002
MIFTS: 29

Pdgfrb-Associated Chronic Eosinophilic Leukemia

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Pdgfrb-Associated Chronic Eosinophilic Leukemia

MalaCards integrated aliases for Pdgfrb-Associated Chronic Eosinophilic Leukemia:

Name: Pdgfrb-Associated Chronic Eosinophilic Leukemia 53 25 73
Atypical Philadelphia-Negative Chronic Myeloid Leukemia 53 25
Primary Eosinophilia with Chronic Myeloproliferative Disorder 25
Clonal Eosinophilia with Chronic Myeloproliferative Disorder 25
Chronic Myeloproliferative Disorder with Eosinophilia 25
Leukemia, Myelomonocytic, Chronic 73
Chronic Myelomonocytic Leukemia 25

Classifications:



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Summaries for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Genetics Home Reference : 25 PDGFRB-associated chronic eosinophilic leukemia is a type of cancer of blood-forming cells. It is characterized by an elevated number of white blood cells called eosinophils in the blood. These cells help fight infections by certain parasites and are involved in the inflammation associated with allergic reactions. However, these circumstances do not account for the increased number of eosinophils in PDGFRB-associated chronic eosinophilic leukemia. Some people with this condition have an increased number of other types of white blood cells, such as neutrophils or mast cells, in addition to eosinophils. People with this condition can have an enlarged spleen (splenomegaly) or enlarged liver (hepatomegaly). Some affected individuals develop skin rashes, likely as a result of an abnormal immune response due to the increased number of eosinophils.

MalaCards based summary : Pdgfrb-Associated Chronic Eosinophilic Leukemia, also known as atypical philadelphia-negative chronic myeloid leukemia, is related to chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia, and has symptoms including fatigue, fever and night sweats. Affiliated tissues include myeloid, neutrophil and skin.

Related Diseases for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 chronic myelomonocytic leukemia 12.5
2 juvenile myelomonocytic leukemia 12.0
3 myelodysplastic syndrome 11.5
4 leukemia 11.1
5 myelodysplastic myeloproliferative cancer 11.1
6 immunodeficiency 21 11.1
7 myeloid leukemia 10.5
8 leukemia, acute myeloid 10.4
9 systemic mastocytosis 10.2
10 myelofibrosis 10.2
11 refractory anemia 10.2
12 myeloproliferative neoplasm 10.1
13 thrombocytopenia 10.1
14 atypical chronic myeloid leukemia 10.1
15 chronic neutrophilic leukemia 10.1
16 hematopoietic stem cell transplantation 10.1
17 leukemia, chronic myeloid 10.1
18 leukemia, chronic lymphocytic 2 10.1
19 leukemia, b-cell, chronic 10.1
20 acute leukemia 10.1
21 leukemia, chronic lymphocytic 10.1
22 lymphoblastic leukemia 10.0
23 sarcoma 10.0
24 leukemia, acute lymphoblastic 10.0
25 myeloma, multiple 10.0
26 lymphoma 10.0
27 histiocytosis 10.0
28 dendritic cell tumor 10.0
29 graft-versus-host disease 10.0
30 purpura 10.0
31 vasculitis 10.0
32 thrombocytopenia due to platelet alloimmunization 9.9
33 splenomegaly 9.9
34 aortitis 9.9
35 mast-cell leukemia 9.9
36 generalized eruptive histiocytosis 9.9
37 indeterminate cell histiocytosis 9.9
38 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.9
39 dermatitis 9.9
40 acquired idiopathic sideroblastic anemia 9.9
41 chronic graft versus host disease 9.9
42 hemopericardium 9.9
43 antiphospholipid syndrome 9.9
44 monocytic leukemia 9.9
45 pericardial effusion 9.9
46 pyoderma gangrenosum 9.9
47 pyridoxine-refractory autosomal recessive sideroblastic anemia 9.9
48 myeloid sarcoma 9.9
49 polyneuropathy 9.9
50 pyoderma 9.9

Graphical network of the top 20 diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:



Diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia

Symptoms & Phenotypes for Pdgfrb-Associated Chronic Eosinophilic Leukemia

UMLS symptoms related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:


fatigue, fever, night sweats

Drugs & Therapeutics for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Search Clinical Trials , NIH Clinical Center for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Genetic Tests for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Anatomical Context for Pdgfrb-Associated Chronic Eosinophilic Leukemia

MalaCards organs/tissues related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:

41
Myeloid, Neutrophil, Skin, Liver, Spleen, Monocytes, Bone

Publications for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Articles related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:

(show top 50) (show all 573)
# Title Authors Year
1
Chronic subdural collection overlying an intra-axial hemorrhagic lesion in chronic myelomonocytic leukemia: special report and review of the literature. ( 29658352 )
2018
2
Evaluation by Flow Cytometry of Mature Monocyte Subpopulations for the Diagnosis and Follow-Up of Chronic Myelomonocytic Leukemia. ( 29707521 )
2018
3
Posaconazole-Induced Adrenal Insufficiency in a Case of Chronic Myelomonocytic Leukemia. ( 29568655 )
2018
4
So-called "blast phase" of chronic myelomonocytic leukemia: a plea for uniform terminology. ( 29955129 )
2018
5
Prognostic Role of Gene Mutations in Chronic Myelomonocytic Leukemia Patients Treated With Hypomethylating Agents. ( 29728305 )
2018
6
A new approach for diagnosing chronic myelomonocytic leukemia using structural parameters of Sysmex XN<sup>TM</sup>analyzers in routine laboratory practice. ( 29310473 )
2018
7
The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia. ( 29797820 )
2018
8
KIT D816V- chronic myelomonocytic leukemia progressing to KIT D816V+ associated to mast cell leukemia responding to allogeneic hematopoietic cell transplantation. ( 29151134 )
2018
9
Chronic myelomonocytic leukemia with central nervous system involvement. ( 29322838 )
2018
10
Blast phase chronic myelomonocytic leukemia: Mayo-MDACC collaborative study of 171 cases. ( 29749401 )
2018
11
Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report. ( 29731877 )
2018
12
Characterization of chronic myelomonocytic leukemia with TP53 mutations. ( 29908419 )
2018
13
Nonhepatosplenic extramedullary manifestations of chronic myelomonocytic leukemia: clinical, molecular and prognostic correlates. ( 29582697 )
2018
14
Chronic Myelomonocytic Leukemia With Fibrosis Is a Distinct Disease Subset With Myeloproliferative Features and Frequent JAK2 p.V617F Mutations. ( 29596070 )
2018
15
Chronic myelomonocytic leukemia: 2018 update on diagnosis, risk stratification and management. ( 29878489 )
2018
16
CBL mutation and MEFV single-nucleotide variant are important genetic predictors of tumor reduction in glucocorticoid-treated patients with chronic myelomonocytic leukemia. ( 29600428 )
2018
17
Leukemia cutis in a patient with chronic myelomonocytic leukemia. ( 29288601 )
2018
18
Prognostic significance of SRSF2 mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia: a meta-analysis. ( 29757120 )
2018
19
Evolving Understanding of Chronic Myelomonocytic Leukemia: Implications for Future Treatment Paradigms. ( 29891120 )
2018
20
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia. ( 29227812 )
2018
21
EZH2 mutations in chronic myelomonocytic leukemia cluster with ASXL1 mutations and their co-occurrence is prognostically detrimental. ( 29358618 )
2018
22
The division of chronic myelomonocytic leukemia (CMML)-1 into CMML-0 and CMML-1 according to 2016 World Health Organization (WHO) classification has no impact in outcome in a large series of patients from the Spanish group of MDS. ( 29775844 )
2018
23
Chronic Myelomonocytic Leukemia following Multicentric Castleman Disease. ( 29607228 )
2018
24
Favorable evolution of lung interstitial disease in a patient with chronic myelomonocytic leukemia treated with azacitidine. ( 29170809 )
2018
25
DNA methylation profile in chronic myelomonocytic leukemia associates with distinct clinical, biological and genetic features. ( 29160764 )
2018
26
Retroperitoneal fibrosis as extramedullary hematopoiesis of a chronic myelomonocytic leukemia. ( 29368535 )
2018
27
Ongoing clonal evolution in chronic myelomonocytic leukemia on hypomethylating agents: a computational perspective. ( 29588547 )
2018
28
A comparison of clinical and molecular characteristics of patients with systemic mastocytosis with chronic myelomonocytic leukemia to CMML alone. ( 29712989 )
2018
29
Exacerbation of mycosis fungoides leading to the diagnosis of chronic myelomonocytic leukemia. ( 29687069 )
2018
30
Blastic Transformation in Mexican Population With Chronic Myelomonocytic Leukemia. ( 28842140 )
2017
31
A phase II, multicentre trial of decitabine in higher-risk chronic myelomonocytic leukemia. ( 28607470 )
2017
32
Prognostic significance of SETBP1 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia, and chronic neutrophilic leukemia: A meta-analysis. ( 28158286 )
2017
33
How I treat chronic myelomonocytic leukemia. ( 28572287 )
2017
34
Successful eltrombopag treatment of severe refractory thrombocytopenia in chronic myelomonocytic leukemia: Two cases reports: A CARE-compliant article. ( 29069007 )
2017
35
Nucleophosmin 1 (NPM1) mutations in chronic myelomonocytic leukemia and their prognostic relevance. ( 28707414 )
2017
36
Genomic determinants of chronic myelomonocytic leukemia. ( 28555081 )
2017
37
Oligomonocytic chronic myelomonocytic leukemia (chronic myelomonocytic leukemia without absolute monocytosis) displays a similar clinicopathologic and mutational profile to classical chronic myelomonocytic leukemia. ( 28548124 )
2017
38
Myeloid neoplasms with features intermediate between primary myelofibrosis and chronic myelomonocytic leukemia. ( 29192651 )
2017
39
Validation of response assessment according to international consortium for MDS/MPN criteria in chronic myelomonocytic leukemia treated with hypomethylating agents. ( 28498370 )
2017
40
Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines. ( 29296739 )
2017
41
Eosinophil-rich tissue infiltrates in chronic myelomonocytic leukemia patients. ( 28593791 )
2017
42
Bone marrow fibrosis in chronic myelomonocytic leukemia is associated with increased megakaryopoiesis, splenomegaly and with a shorter median time to disease progression. ( 29262560 )
2017
43
Models of Prognostication in Chronic Myelomonocytic Leukemia. ( 29064026 )
2017
44
Randomized Phase II Study of Azacitidine Alone or in Combination With Lenalidomide or With Vorinostat in Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: North American Intergroup Study SWOG S1117. ( 28486043 )
2017
45
Phase I study of panobinostat and 5-azacitidine in Japanese patients with myelodysplastic syndrome or chronic myelomonocytic leukemia. ( 28905323 )
2017
46
Flow cytometry based monocyte subset analysis accurately distinguishes chronic myelomonocytic leukemia from myeloproliferative neoplasms with associated monocytosis. ( 28731458 )
2017
47
Cytogenetic risk stratification may predict allogeneic hematopoietic stem cell transplantation outcomes for chronic myelomonocytic leukemia. ( 29032731 )
2017
48
Chronic myelomonocytic leukemia masquerading as cutaneous indeterminate dendritic cell tumor: Expanding the spectrum of skin lesions in chronic myelomonocytic leukemia. ( 28885734 )
2017
49
Posttransplantation relapse of pediatric chronic myelomonocytic leukemia cured using donor lymphocyte infusion. ( 28895279 )
2017
50
A phase I study of lenalidomide in patients with chronic myelomonocytic leukemia (CMML) - AGMT_CMML-1. ( 28853315 )
2017

Variations for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Expression for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Search GEO for disease gene expression data for Pdgfrb-Associated Chronic Eosinophilic Leukemia.

Pathways for Pdgfrb-Associated Chronic Eosinophilic Leukemia

GO Terms for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Sources for Pdgfrb-Associated Chronic Eosinophilic Leukemia

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