MCID: PDG002
MIFTS: 29

Pdgfrb-Associated Chronic Eosinophilic Leukemia

Categories: Cancer diseases, Immune diseases, Liver diseases, Rare diseases

Aliases & Classifications for Pdgfrb-Associated Chronic Eosinophilic Leukemia

MalaCards integrated aliases for Pdgfrb-Associated Chronic Eosinophilic Leukemia:

Name: Pdgfrb-Associated Chronic Eosinophilic Leukemia 54 26 74
Atypical Philadelphia-Negative Chronic Myeloid Leukemia 54 26
Primary Eosinophilia with Chronic Myeloproliferative Disorder 26
Clonal Eosinophilia with Chronic Myeloproliferative Disorder 26
Chronic Myeloproliferative Disorder with Eosinophilia 26
Leukemia, Myelomonocytic, Chronic 74
Chronic Myelomonocytic Leukemia 26

Classifications:



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Summaries for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Genetics Home Reference : 26 PDGFRB-associated chronic eosinophilic leukemia is a type of cancer of blood-forming cells. It is characterized by an elevated number of white blood cells called eosinophils in the blood. These cells help fight infections by certain parasites and are involved in the inflammation associated with allergic reactions. However, these circumstances do not account for the increased number of eosinophils in PDGFRB-associated chronic eosinophilic leukemia. Some people with this condition have an increased number of other types of white blood cells, such as neutrophils or mast cells, in addition to eosinophils. People with this condition can have an enlarged spleen (splenomegaly) or enlarged liver (hepatomegaly). Some affected individuals develop skin rashes, likely as a result of an abnormal immune response due to the increased number of eosinophils.

MalaCards based summary : Pdgfrb-Associated Chronic Eosinophilic Leukemia, also known as atypical philadelphia-negative chronic myeloid leukemia, is related to chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia, and has symptoms including fever, fatigue and night sweats. Affiliated tissues include myeloid, neutrophil and skin.

Related Diseases for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 chronic myelomonocytic leukemia 12.9
2 juvenile myelomonocytic leukemia 12.2
3 myelodysplastic syndrome 11.7
4 leukemia 11.3
5 myelodysplastic myeloproliferative cancer 11.3
6 myeloid leukemia 10.7
7 leukemia, acute myeloid 10.6
8 mastocytosis 10.4
9 lymphocytic leukemia 10.4
10 myelofibrosis 10.3
11 systemic mastocytosis 10.3
12 atypical chronic myeloid leukemia 10.3
13 refractory anemia 10.3
14 hematopoietic stem cell transplantation 10.3
15 thrombocytopenia 10.3
16 lymphoma 10.3
17 chronic neutrophilic leukemia 10.3
18 leukemia, chronic lymphocytic 2 10.2
19 leukemia, chronic lymphocytic 10.2
20 leukemia, chronic myeloid 10.2
21 chromosomal triplication 10.2
22 dendritic cell tumor 10.2
23 leukemia, b-cell, chronic 10.2
24 myeloma, multiple 10.2
25 leukemia, acute lymphoblastic 10.2
26 acute leukemia 10.2
27 sarcoma 10.2
28 dermatitis 10.2
29 purpura 10.2
30 histiocytosis 10.2
31 vasculitis 10.2
32 hypereosinophilic syndrome 10.2
33 graft-versus-host disease 10.1
34 granulomatous dermatitis 10.1
35 blastic plasmacytoid dendritic cell 10.1
36 hepatocellular carcinoma 10.0
37 polycythemia vera 10.0
38 thrombotic thrombocytopenic purpura 10.0
39 hemopericardium 10.0
40 cardiac tamponade 10.0
41 pericardial effusion 10.0
42 polyneuropathy 10.0
43 thrombocytopenia due to platelet alloimmunization 10.0
44 antiphospholipid syndrome 10.0
45 pyoderma 10.0
46 aortitis 10.0
47 polycythemia 10.0
48 monocytic leukemia 10.0
49 pyoderma gangrenosum 10.0
50 myeloid sarcoma 10.0

Graphical network of the top 20 diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:



Diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia

Symptoms & Phenotypes for Pdgfrb-Associated Chronic Eosinophilic Leukemia

UMLS symptoms related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:


fever, fatigue, night sweats

Drugs & Therapeutics for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Search Clinical Trials , NIH Clinical Center for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Genetic Tests for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Anatomical Context for Pdgfrb-Associated Chronic Eosinophilic Leukemia

MalaCards organs/tissues related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:

42
Myeloid, Neutrophil, Skin, Monocytes, Bone, Spleen, Bone Marrow

Publications for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Articles related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:

(show top 50) (show all 662)
# Title Authors Year
1
Massive Hemoptysis Due to the Rupture of Thoracic Aortic Aneurysm Caused by Leukemic Cell Infiltration in a Patient With Chronic Myelomonocytic Leukemia. ( 30701008 )
2019
2
Comprehensive mutation profiling and mRNA expression analysis in atypical chronic myeloid leukemia in comparison with chronic myelomonocytic leukemia. ( 30635983 )
2019
3
Coincidence of lymphomatoid granulomatosis, chronic myelomonocytic leukemia, and anaplastic T cell lymphoma after methotrexate therapy for rheumatoid arthritis. ( 29982850 )
2019
4
Cardiovascular disease in chronic myelomonocytic leukemia: do monocytosis and chronic inflammation predispose to accelerated atherosclerosis? ( 30182347 )
2019
5
A phase II study of omacetaxine mepesuccinate for patients with higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia after failure of hypomethylating agents. ( 30328139 )
2019
6
Utility of JAK2 V617F allelic burden in distinguishing chronic myelomonocytic Leukemia from Primary myelofibrosis with monocytosis. ( 30447300 )
2019
7
Clinical correlates, prognostic impact and survival outcomes in chronic myelomonocytic leukemia patients with the JAK2V617F mutation. ( 30606787 )
2019
8
Real Life Data on Efficacy and Safety of Azacitidine Therapy for Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia and Acute Myeloid Leukemia. ( 30613922 )
2019
9
Trends of incidence and survival of patients with chronic myelomonocytic leukemia between 1999 and 2014: A comparison between Swiss and American population-based cancer registries. ( 30690330 )
2019
10
GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice. ( 30710465 )
2019
11
Update on the pathologic diagnosis of chronic myelomonocytic leukemia. ( 30723295 )
2019
12
Molecular Cytogenetic Characterization of a Case of a Myelodysplastic/Myeloproliferative Neoplasm, Chronic Myelomonocytic Leukemia-1 (CMML-1) with Abnormal Karyotype with an Apparent Monosomy 7 Resulting in Rearrangements Involving Chromosomes 7 and 21. ( 30840601 )
2019
13
Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia. ( 30894665 )
2019
14
Predictive Model for Infection Risk in Myelodysplastic Syndromes, Acute Myeloid Leukemia, and Chronic Myelomonocytic Leukemia Patients Treated With Azacitidine; Azacitidine Infection Risk Model: The Polish Adult Leukemia Group Study. ( 30898482 )
2019
15
Leukemoid reaction in chronic myelomonocytic leukemia patients undergoing surgery: perioperative management recommendations. ( 30923049 )
2019
16
NUP98-HBO1-fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis. ( 30944097 )
2019
17
Chronic myelomonocytic leukemia as a transformation from polycythemia vera. ( 30949429 )
2019
18
Autoantibodies in myelodysplastic syndromes and chronic myelomonocytic leukemia. ( 30958078 )
2019
19
Suboptimal response rates to hypomethylating agent therapy in chronic myelomonocytic leukemia; a single institutional study of 121 patients. ( 30964202 )
2019
20
A case of palisaded neutrophilic granulomatous dermatitis with subsequent development of chronic myelomonocytic leukemia. ( 30997066 )
2019
21
Coombs-positive refractory acquired thrombotic thrombocytopenic purpura in a patient with chronic myelomonocytic leukemia successfully treated with rituximab. ( 31007140 )
2019
22
Multilayer intraclonal heterogeneity in chronic myelomonocytic leukemia. ( 31048357 )
2019
23
TUMOR LYSIS SYNDROME DUE TO TARGETING OF HEPATOCELLULAR CARCINOMA ASSOCIATED WITH CHRONIC MYELOMONOCYTIC LEUKEMIA ( 31067853 )
2019
24
Chronic Myelomonocytic Leukemia: 2018 Update to Prognosis and Treatment. ( 31093889 )
2019
25
Chronic myelomonocytic leukemia-related vasculitis mimicking giant cell arteritis. ( 31109503 )
2019
26
Palisaded neutrophilic and granulomatous dermatitis in a patient with chronic myelomonocytic leukemia. ( 30773700 )
2019
27
Biallelic inactivation of the retinoblastoma gene results in transformation of chronic myelomonocytic leukemia to a blastic plasmacytoid dendritic cell neoplasm: shared clonal origins of two aggressive neoplasms. ( 30190511 )
2018
28
Chronic Myelomonocytic Leukemia following Multicentric Castleman Disease. ( 29607228 )
2018
29
Retroperitoneal fibrosis as extramedullary hematopoiesis of a chronic myelomonocytic leukemia. ( 29368535 )
2018
30
Systematic Literature Review of Treatment Options and Clinical Outcomes for Patients With Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia. ( 29475821 )
2018
31
Association of bone marrow fibrosis with inferior survival outcomes in chronic myelomonocytic leukemia. ( 29557496 )
2018
32
Posaconazole-Induced Adrenal Insufficiency in a Case of Chronic Myelomonocytic Leukemia. ( 29568655 )
2018
33
Nonhepatosplenic extramedullary manifestations of chronic myelomonocytic leukemia: clinical, molecular and prognostic correlates. ( 29582697 )
2018
34
Ongoing clonal evolution in chronic myelomonocytic leukemia on hypomethylating agents: a computational perspective. ( 29588547 )
2018
35
Chronic Myelomonocytic Leukemia With Fibrosis Is a Distinct Disease Subset With Myeloproliferative Features and Frequent JAK2 p.V617F Mutations. ( 29596070 )
2018
36
CBL mutation and MEFV single-nucleotide variant are important genetic predictors of tumor reduction in glucocorticoid-treated patients with chronic myelomonocytic leukemia. ( 29600428 )
2018
37
Chronic subdural collection overlying an intra-axial hemorrhagic lesion in chronic myelomonocytic leukemia: special report and review of the literature. ( 29658352 )
2018
38
Exacerbation of mycosis fungoides leading to the diagnosis of chronic myelomonocytic leukemia. ( 29687069 )
2018
39
Evaluation by Flow Cytometry of Mature Monocyte Subpopulations for the Diagnosis and Follow-Up of Chronic Myelomonocytic Leukemia. ( 29707521 )
2018
40
A comparison of clinical and molecular characteristics of patients with systemic mastocytosis with chronic myelomonocytic leukemia to CMML alone. ( 29712989 )
2018
41
Prognostic Role of Gene Mutations in Chronic Myelomonocytic Leukemia Patients Treated With Hypomethylating Agents. ( 29728305 )
2018
42
Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report. ( 29731877 )
2018
43
Blast phase chronic myelomonocytic leukemia: Mayo-MDACC collaborative study of 171 cases. ( 29749401 )
2018
44
Prognostic significance of SRSF2 mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia: a meta-analysis. ( 29757120 )
2018
45
The division of chronic myelomonocytic leukemia (CMML)-1 into CMML-0 and CMML-1 according to 2016 World Health Organization (WHO) classification has no impact in outcome in a large series of patients from the Spanish group of MDS. ( 29775844 )
2018
46
The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia. ( 29797820 )
2018
47
Chronic myelomonocytic leukemia: 2018 update on diagnosis, risk stratification and management. ( 29878489 )
2018
48
Evolving Understanding of Chronic Myelomonocytic Leukemia: Implications for Future Treatment Paradigms. ( 29891120 )
2018
49
Characterization of chronic myelomonocytic leukemia with TP53 mutations. ( 29908419 )
2018
50
So-called "blast phase" of chronic myelomonocytic leukemia: a plea for uniform terminology. ( 29955129 )
2018

Variations for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Expression for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Search GEO for disease gene expression data for Pdgfrb-Associated Chronic Eosinophilic Leukemia.

Pathways for Pdgfrb-Associated Chronic Eosinophilic Leukemia

GO Terms for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Sources for Pdgfrb-Associated Chronic Eosinophilic Leukemia

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