MCID: PDT004
MIFTS: 29

Pediatric Angiosarcoma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Pediatric Angiosarcoma

MalaCards integrated aliases for Pediatric Angiosarcoma:

Name: Pediatric Angiosarcoma 12 15
Paediatric Hemangiosarcoma 12
Pediatric Hemangiosarcoma 12
Paediatric Angiosarcoma 12
Childhood Angiosarcoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4505
NCIt 50 C9174
UMLS 70 C0279988

Summaries for Pediatric Angiosarcoma

Disease Ontology : 12 An angiosarcoma that affects children.

MalaCards based summary : Pediatric Angiosarcoma, also known as paediatric hemangiosarcoma, is related to hemangiopericytoma, malignant and epithelioid sarcoma. An important gene associated with Pediatric Angiosarcoma is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Fluid shear stress and atherosclerosis. The drugs Etoposide and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotype is homeostasis/metabolism.

Related Diseases for Pediatric Angiosarcoma

Diseases related to Pediatric Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 hemangiopericytoma, malignant 30.0 PECAM1 CD34
2 epithelioid sarcoma 29.9 PECAM1 CD34
3 kaposi sarcoma 29.4 VEGFA TP53 CD34
4 angiosarcoma 29.2 VWF VEGFA TP53 PECAM1 CD34
5 angiolipoma 10.3 PECAM1 CD34
6 glomangioma 10.3 PECAM1 CD34
7 skin epithelioid hemangioma 10.2 PECAM1 CD34
8 aortic malignant tumor 10.2 PECAM1 CD34
9 central nervous system angiosarcoma 10.2 PECAM1 CD34
10 intravascular angioleiomyoma 10.2 PECAM1 CD34
11 heart fibrosarcoma 10.2 PECAM1 CD34
12 ovarian angiosarcoma 10.2 PECAM1 CD34
13 conventional angiosarcoma 10.2 PECAM1 CD34
14 gallbladder leiomyosarcoma 10.2 PECAM1 CD34
15 thyroid sarcoma 10.2 PECAM1 CD34
16 angiomyoma 10.2 PECAM1 CD34
17 glomangiosarcoma 10.2 PECAM1 CD34
18 hemangioma of spleen 10.2 PECAM1 CD34
19 intramuscular hemangioma 10.2 PECAM1 CD34
20 liposarcoma of bone 10.2 PECAM1 CD34
21 colonic lymphangioma 10.2 PECAM1 CD34
22 liver leiomyoma 10.2 PECAM1 CD34
23 benign perivascular tumor 10.2 PECAM1 CD34
24 perivascular tumor 10.2 PECAM1 CD34
25 breast angiosarcoma 10.2 PECAM1 CD34
26 erythema elevatum diutinum 10.2 PECAM1 CD34
27 sarcomatoid squamous cell skin carcinoma 10.2 PECAM1 CD34
28 heart sarcoma 10.2 PECAM1 CD34
29 skin sarcoma 10.2 PECAM1 CD34
30 pulmonary artery leiomyosarcoma 10.2 PECAM1 CD34
31 subungual glomus tumor 10.2 PECAM1 CD34
32 vulvar leiomyoma 10.2 PECAM1 CD34
33 intravascular fasciitis 10.2 PECAM1 CD34
34 histiocytoid hemangioma 10.2 PECAM1 CD34
35 adenoid squamous cell carcinoma 10.2 PECAM1 CD34
36 heart cancer 10.2 PECAM1 CD34
37 benign peritoneal mesothelioma 10.2 PECAM1 CD34
38 cystic lymphangioma 10.2 PECAM1 CD34
39 pseudosarcomatous fibromatosis 10.2 PECAM1 CD34
40 urethra transitional cell carcinoma 10.2 TP53 PECAM1
41 middle ear adenocarcinoma 10.2 VWF PECAM1
42 liver angiosarcoma 10.2 TP53 PECAM1
43 benign pleural mesothelioma 10.2 TP53 CD34
44 multifocal osteogenic sarcoma 10.2 TP53 CD34
45 papillary adenofibroma 10.2 VWF CD34
46 lipomatosis, multiple 10.2 PECAM1 CD34
47 pediatric liposarcoma 10.2 TP53 CD34
48 glomus tumor 10.1 TP53 CD34
49 fasciitis 10.1 TP53 CD34
50 adult malignant schwannoma 10.1 TP53 CD34

Graphical network of the top 20 diseases related to Pediatric Angiosarcoma:



Diseases related to Pediatric Angiosarcoma

Symptoms & Phenotypes for Pediatric Angiosarcoma

MGI Mouse Phenotypes related to Pediatric Angiosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 CD34 F8 PECAM1 TCHP TP53 VEGFA

Drugs & Therapeutics for Pediatric Angiosarcoma

Drugs for Pediatric Angiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3 33419-42-0 36462
2
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
3
Epirubicin Approved Phase 3 56420-45-2 41867
4
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
5
Ifosfamide Approved Phase 3 3778-73-2 3690
6
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
7
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
8
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
9
Cyproheptadine Approved Phase 3 129-03-3 2913
10 Tubulin Modulators Phase 3
11 Antibiotics, Antitubercular Phase 3
12 Immunosuppressive Agents Phase 3
13 Alkylating Agents Phase 3
14 Anti-Infective Agents Phase 3
15 Antirheumatic Agents Phase 3
16 Immunologic Factors Phase 3
17 Etoposide phosphate Phase 3
18 Anti-Bacterial Agents Phase 3
19
Isophosphamide mustard Phase 3 100427
20 Antimitotic Agents Phase 3
21 Gastrointestinal Agents Phase 3
22 Neurotransmitter Agents Phase 3
23 Dermatologic Agents Phase 3
24
Histamine Phosphate Phase 3 51-74-1 65513
25 Histamine H1 Antagonists Phase 3
26 Histamine Antagonists Phase 3
27 Anti-Allergic Agents Phase 3
28
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
29
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
30
Lenograstim Approved, Investigational Phase 2 135968-09-1
31 Imatinib Mesylate Phase 2 220127-57-1 123596
32 Protein Kinase Inhibitors Phase 2
33
Liposomal doxorubicin Phase 2 31703
34
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
35 Analgesics, Non-Narcotic Phase 1
36 Cyclooxygenase 2 Inhibitors Phase 1
37 Analgesics Phase 1
38 Cyclooxygenase Inhibitors Phase 1
39 Anti-Inflammatory Agents Phase 1
40 Anti-Inflammatory Agents, Non-Steroidal Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 MMT 95 Study For Rhabdomyosarcoma and Other Malignant Soft Tissue Tumors of Childhood Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
3 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
4 Phase II Trial of Gleevec (Formerly Known as STI571) in Patients With Soft Tissue and Bone Sarcomas: A Multi-Disciplinary Trial of the North American Sarcoma Study Group of the Connective Tissue Oncology Society Completed NCT00031915 Phase 2 imatinib mesylate
5 MMT 98 Study For Metastatic Disease Rhabdomyosarcoma And Other Malignant Soft Tissue Sarcoma Of Childhood Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
6 A Phase I Trial of Postoperative Radiation With Dose-Escalation of A Cox-2 Inhibitor, Celebrex™ (CELECOXIB) in Patients With Soft Tissue Sarcoma of the Extremity Completed NCT00450736 Phase 1 celecoxib
7 Prevention of Mucositis in Children With AES-14 (IND#36978), a Glutamine Based Oral Care Regimen, for Patients Diagnosed With Solid Tumors: A Randomized Placebo-Controlled Clinical Study Withdrawn NCT00334984 glutamine

Search NIH Clinical Center for Pediatric Angiosarcoma

Genetic Tests for Pediatric Angiosarcoma

Anatomical Context for Pediatric Angiosarcoma

MalaCards organs/tissues related to Pediatric Angiosarcoma:

40
Bone

Publications for Pediatric Angiosarcoma

Articles related to Pediatric Angiosarcoma:

# Title Authors PMID Year
1
Hepatic vascular malignancies in children are associated with increased rates of surgical resection and improved overall survival compared with adults. 61
33661569 2021
2
Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. 61
29863582 2018
3
A 15-Year-Old Male Baseball Player With a Mass in the Brachialis Muscle. 61
27045482 2016
4
Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity. 61
20196675 2010
5
Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature. 61
16880251 2006
6
Pediatric angiosarcoma of the heart: a unique presentation and metastatic pattern. 61
11779052 2001
7
VEGF and its receptors are expressed in a pediatric angiosarcoma in a patient with Aicardi's syndrome. 61
10844570 2000

Variations for Pediatric Angiosarcoma

Expression for Pediatric Angiosarcoma

Search GEO for disease gene expression data for Pediatric Angiosarcoma.

Pathways for Pediatric Angiosarcoma

GO Terms for Pediatric Angiosarcoma

Cellular components related to Pediatric Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.8 VWF VEGFA F8

Biological processes related to Pediatric Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.58 VEGFA TP53 CD34
2 hemostasis GO:0007599 9.43 VWF F8
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.43 VEGFA TP53 PECAM1
4 blood coagulation, intrinsic pathway GO:0007597 9.37 VWF F8
5 vascular wound healing GO:0061042 9.32 VEGFA CD34
6 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.16 VEGFA TP53
7 glomerular endothelium development GO:0072011 8.96 PECAM1 CD34
8 platelet degranulation GO:0002576 8.92 VWF VEGFA PECAM1 F8

Sources for Pediatric Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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