MCID: PDT004
MIFTS: 29

Pediatric Angiosarcoma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Pediatric Angiosarcoma

MalaCards integrated aliases for Pediatric Angiosarcoma:

Name: Pediatric Angiosarcoma 12 15
Pediatric Hemangiosarcoma 12
Childhood Angiosarcoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4505
NCIt 50 C9174
UMLS 73 C0279988

Summaries for Pediatric Angiosarcoma

Disease Ontology : 12 An angiosarcoma that affects children.

MalaCards based summary : Pediatric Angiosarcoma, also known as pediatric hemangiosarcoma, is related to skin epithelioid hemangioma and ovary sarcoma. An important gene associated with Pediatric Angiosarcoma is HBA1 (Hemoglobin Subunit Alpha 1). The drugs Mechlorethamine and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and skin.

Related Diseases for Pediatric Angiosarcoma

Diseases related to Pediatric Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 skin epithelioid hemangioma 10.1 CD34 HBA1
2 ovary sarcoma 10.1 CD34 HBA1
3 ovarian angiosarcoma 10.1 CD34 HBA1
4 intravascular fasciitis 10.1 CD34 HBA1
5 thyroid angiosarcoma 10.1 CD34 HBA1
6 spleen angiosarcoma 10.1 CD34 HBA1
7 bone epithelioid hemangioma 10.1 CD34 HBA1
8 thyroid sarcoma 10.1 CD34 HBA1
9 hordeolum 10.1 CD34 HBA1
10 hemangioma of liver 10.1 CD34 HBA1
11 conventional angiosarcoma 10.1 CD34 HBA1
12 venous hemangioma 10.1 CD34 HBA1
13 mixed liposarcoma 10.1 CD34 HBA1
14 erythema elevatum diutinum 10.1 CD34 HBA1
15 senile angioma 10.1 CD34 HBA1
16 interstitial emphysema 10.1 CD34 HBA1
17 angiomyoma 10.0 CD34 HBA1
18 chorioangioma 10.0 CD34 HBA1
19 spindle cell liposarcoma 10.0 CD34 HBA1
20 alveoli adenoma 10.0 CD34 HBA1
21 hemangioma 10.0 CD34 VEGFA
22 mesenchymal cell neoplasm 10.0 CD34 HBA1
23 infiltrating lipoma 10.0 CD34 HBA1
24 angiosarcoma 10.0
25 hemangioma of intra-abdominal structure 10.0 CD34 HBA1
26 hypoglycemic coma 10.0 HBA1 VEGFA
27 liver angiosarcoma 10.0 CD34 HBA1
28 congenital epulis 10.0 CD34 HBA1
29 skin hemangioma 10.0 HBA1 VEGFA
30 capillary hemangioma 10.0 HBA1 VEGFA
31 nephrogenic adenofibroma 10.0 CD34 HBA1
32 drug-induced lupus erythematosus 10.0 HBA1 VEGFA
33 angiomatous meningioma 10.0 HBA1 VEGFA
34 skin benign neoplasm 10.0 CD34 HBA1
35 lymphangioma 10.0 HBA1 VEGFA
36 histiocytoid hemangioma 10.0 F8 HBA1
37 retinal vascular disease 9.9 HBA1 VEGFA
38 idiopathic interstitial pneumonia 9.9 CD34 VEGFA
39 nervous system cancer 9.9 CD34 VEGFA
40 pericardium cancer 9.9 F8 HBA1
41 indeterminate leprosy 9.9 F8 HBA1
42 microcystic meningioma 9.9 F8 VEGFA
43 gastrointestinal system cancer 9.9 CD34 VEGFA
44 meningioma, familial 9.9 CD34 VEGFA
45 gastrointestinal stromal tumor 9.9 CD34 VEGFA
46 retinal artery occlusion 9.9 F8 VEGFA
47 vein disease 9.8 F8 VEGFA
48 glomeruloid hemangioma 9.8 CD34 HBA1 VEGFA
49 vascular cancer 9.8 CD34 HBA1 VEGFA
50 connective tissue cancer 9.8 CD34 HBA1 VEGFA

Graphical network of the top 20 diseases related to Pediatric Angiosarcoma:



Diseases related to Pediatric Angiosarcoma

Symptoms & Phenotypes for Pediatric Angiosarcoma

Drugs & Therapeutics for Pediatric Angiosarcoma

Drugs for Pediatric Angiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
4
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
5
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
6
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
8
Vincristine Approved, Investigational Phase 3,Phase 2 57-22-7, 2068-78-2 5978
9
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
10
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
11
Cyproheptadine Approved Phase 3 129-03-3 2913
12
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
13
Isophosphamide mustard Phase 3,Phase 2 0
14 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
15 Antineoplastic Agents, Alkylating Phase 3,Phase 2
16 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
17 Alkylating Agents Phase 3,Phase 2
18 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
19 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
20 Immunologic Factors Phase 3,Phase 2
21 Anti-Infective Agents Phase 3,Phase 2
22 Etoposide phosphate Phase 3,Phase 2
23 Antimitotic Agents Phase 3,Phase 2
24 Antirheumatic Agents Phase 3,Phase 2,Phase 1
25 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
26 Immunosuppressive Agents Phase 3,Phase 2
27 Serotonin Agents Phase 3
28 Anti-Allergic Agents Phase 3
29 Serotonin Antagonists Phase 3
30 Histamine H1 Antagonists Phase 3
31
Histamine Phosphate Phase 3 51-74-1 65513
32 Antipruritics Phase 3
33 Neurotransmitter Agents Phase 3
34 Dermatologic Agents Phase 3
35 Histamine Antagonists Phase 3
36 Gastrointestinal Agents Phase 3
37
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
38
Everolimus Approved Phase 2 159351-69-6 6442177
39
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
40
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
41
Lenograstim Approved, Investigational Phase 2 135968-09-1
42 Antibodies Phase 2,Phase 1
43 Antibodies, Monoclonal Phase 2,Phase 1
44 Immunoglobulins Phase 2,Phase 1
45 Antifungal Agents Phase 2
46 Imatinib Mesylate Phase 2 220127-57-1 123596
47 Protein Kinase Inhibitors Phase 2
48
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
49 Anti-Inflammatory Agents, Non-Steroidal Phase 1
50 Cyclooxygenase 2 Inhibitors Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
3 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma Completed NCT01614795 Phase 2 Temsirolimus
6 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate
7 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
8 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
9 Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery Completed NCT00450736 Phase 1 celecoxib
10 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
11 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 Not Applicable glutamine

Search NIH Clinical Center for Pediatric Angiosarcoma

Genetic Tests for Pediatric Angiosarcoma

Anatomical Context for Pediatric Angiosarcoma

MalaCards organs/tissues related to Pediatric Angiosarcoma:

41
Bone, Heart, Skin, Liver, Ovary, Spleen, Thyroid

Publications for Pediatric Angiosarcoma

Articles related to Pediatric Angiosarcoma:

# Title Authors Year
1
Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. ( 29863582 )
2018
2
Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity. ( 20196675 )
2010
3
Pediatric angiosarcoma of the heart: a unique presentation and metastatic pattern. ( 11779052 )
2001
4
VEGF and its receptors are expressed in a pediatric angiosarcoma in a patient with Aicardi's syndrome. ( 10844570 )
2000

Variations for Pediatric Angiosarcoma

Expression for Pediatric Angiosarcoma

Search GEO for disease gene expression data for Pediatric Angiosarcoma.

Pathways for Pediatric Angiosarcoma

GO Terms for Pediatric Angiosarcoma

Cellular components related to Pediatric Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 CD34 F8 HBA1 VEGFA
2 platelet alpha granule lumen GO:0031093 8.62 F8 VEGFA

Biological processes related to Pediatric Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 8.96 CD34 VEGFA
2 platelet degranulation GO:0002576 8.62 F8 VEGFA

Sources for Pediatric Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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