MCID: PDT004
MIFTS: 27

Pediatric Angiosarcoma

Categories: Cancer diseases

Aliases & Classifications for Pediatric Angiosarcoma

MalaCards integrated aliases for Pediatric Angiosarcoma:

Name: Pediatric Angiosarcoma 12 15
Pediatric Hemangiosarcoma 12
Childhood Angiosarcoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4505
NCIt 50 C9174
UMLS 73 C0279988

Summaries for Pediatric Angiosarcoma

Disease Ontology : 12 An angiosarcoma that affects children.

MalaCards based summary : Pediatric Angiosarcoma, also known as pediatric hemangiosarcoma, is related to ovary sarcoma and ovarian angiosarcoma. An important gene associated with Pediatric Angiosarcoma is HBA1 (Hemoglobin Subunit Alpha 1). The drugs Doxorubicin and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include bone and heart.

Related Diseases for Pediatric Angiosarcoma

Diseases related to Pediatric Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 ovary sarcoma 10.2 CD34 HBA1
2 ovarian angiosarcoma 10.2 CD34 HBA1
3 intravascular fasciitis 10.2 CD34 HBA1
4 thyroid angiosarcoma 10.2 CD34 HBA1
5 neurogenic arthropathy 10.2 CD34 HBA1
6 spleen angiosarcoma 10.2 CD34 HBA1
7 bone epithelioid hemangioma 10.2 CD34 HBA1
8 thyroid sarcoma 10.2 CD34 HBA1
9 hemangioma of liver 10.2 CD34 HBA1
10 extraosseous osteosarcoma 10.2 CD34 HBA1
11 breast angiosarcoma 10.2 CD34 HBA1
12 conventional angiosarcoma 10.2 CD34 HBA1
13 venous hemangioma 10.2 CD34 HBA1
14 mixed liposarcoma 10.2 CD34 HBA1
15 senile angioma 10.2 CD34 HBA1
16 interstitial emphysema 10.2 CD34 HBA1
17 angiomyoma 10.2 CD34 HBA1
18 chorioangioma 10.1 CD34 HBA1
19 spindle cell liposarcoma 10.1 CD34 HBA1
20 mesenchymal cell neoplasm 10.1 CD34 HBA1
21 infiltrating lipoma 10.1 CD34 HBA1
22 hemangioma of intra-abdominal structure 10.1 CD34 HBA1
23 congenital epulis 10.1 CD34 HBA1
24 hypoglycemic coma 10.1 HBA1 VEGFA
25 liver angiosarcoma 10.1 CD34 HBA1
26 cardiovascular organ benign neoplasm 10.1 CD34 HBA1
27 capillary hemangioma 10.0 HBA1 VEGFA
28 skin hemangioma 10.0 HBA1 VEGFA
29 benign perivascular tumor 10.0 CD34 HBA1
30 nephrogenic adenofibroma 10.0 CD34 HBA1
31 angiomatous meningioma 10.0 HBA1 VEGFA
32 glomangioma 10.0 CD34 HBA1
33 lymphangioma 10.0 HBA1 VEGFA
34 angiosarcoma 9.9
35 vascular cancer 9.9 HBA1 VEGFA
36 retinal vascular disease 9.8 HBA1 VEGFA
37 idiopathic interstitial pneumonia 9.8 CD34 VEGFA
38 pericardium cancer 9.7 F8 HBA1
39 hemangioma 9.7 CD34 VEGFA
40 indeterminate leprosy 9.7 F8 HBA1
41 microcystic meningioma 9.7 F8 VEGFA
42 gastrointestinal system cancer 9.7 CD34 VEGFA
43 gastrointestinal stromal tumor 9.6 CD34 VEGFA
44 immune system disease 9.5 CD34 F8
45 glomeruloid hemangioma 9.5 CD34 HBA1 VEGFA
46 connective tissue cancer 9.5 CD34 HBA1 VEGFA
47 cell type cancer 9.5 CD34 HBA1 VEGFA
48 myeloma, multiple 9.5 CD34 VEGFA
49 hobnail hemangioma 9.3 CD34 F8 HBA1
50 spleen cancer 9.3 CD34 F8 HBA1

Graphical network of the top 20 diseases related to Pediatric Angiosarcoma:



Diseases related to Pediatric Angiosarcoma

Symptoms & Phenotypes for Pediatric Angiosarcoma

Drugs & Therapeutics for Pediatric Angiosarcoma

Drugs for Pediatric Angiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
3
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
4
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
5
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
6
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
8
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 2019 457193
9
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
10
Cyproheptadine Approved Phase 3 129-03-3 2913
11
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
12
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
13
Isophosphamide mustard Phase 3,Phase 2 0
14 Alkylating Agents Phase 3,Phase 2
15 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
16 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
17 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
18 Antineoplastic Agents, Alkylating Phase 3,Phase 2
19 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
20 Etoposide phosphate Phase 3,Phase 2
21 Immunosuppressive Agents Phase 3,Phase 2
22 Anti-Infective Agents Phase 3,Phase 2
23 Antirheumatic Agents Phase 3,Phase 2,Phase 1
24 Antimitotic Agents Phase 3,Phase 2
25 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
26
Histamine Phosphate Phase 3 51-74-1 65513
27 Serotonin Agents Phase 3
28 Serotonin Antagonists Phase 3
29 Gastrointestinal Agents Phase 3
30 Neurotransmitter Agents Phase 3
31 Histamine Antagonists Phase 3
32 Histamine H1 Antagonists Phase 3
33 Dermatologic Agents Phase 3
34 Anti-Allergic Agents Phase 3
35 Antipruritics Phase 3
36
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
37
Lenograstim Approved, Investigational Phase 2 135968-09-1
38
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
39
Everolimus Approved Phase 2 159351-69-6 6442177
40
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
41 Imatinib Mesylate Phase 2 220127-57-1 123596
42 Antibodies Phase 2,Phase 1
43 Immunoglobulins Phase 2,Phase 1
44 Antibodies, Monoclonal Phase 2,Phase 1
45 Antifungal Agents Phase 2
46 Protein Kinase Inhibitors Phase 2
47
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
48 Analgesics Phase 1
49 Cyclooxygenase 2 Inhibitors Phase 1
50 Cyclooxygenase Inhibitors Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
3 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma Completed NCT01614795 Phase 2 Temsirolimus
6 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate
7 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
8 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
9 Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery Completed NCT00450736 Phase 1 celecoxib
10 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
11 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 Not Applicable glutamine

Search NIH Clinical Center for Pediatric Angiosarcoma

Genetic Tests for Pediatric Angiosarcoma

Anatomical Context for Pediatric Angiosarcoma

MalaCards organs/tissues related to Pediatric Angiosarcoma:

41
Bone, Heart

Publications for Pediatric Angiosarcoma

Articles related to Pediatric Angiosarcoma:

# Title Authors Year
1
Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. ( 29863582 )
2018
2
Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity. ( 20196675 )
2010
3
Pediatric angiosarcoma of the heart: a unique presentation and metastatic pattern. ( 11779052 )
2001
4
VEGF and its receptors are expressed in a pediatric angiosarcoma in a patient with Aicardi's syndrome. ( 10844570 )
2000

Variations for Pediatric Angiosarcoma

Expression for Pediatric Angiosarcoma

Search GEO for disease gene expression data for Pediatric Angiosarcoma.

Pathways for Pediatric Angiosarcoma

GO Terms for Pediatric Angiosarcoma

Cellular components related to Pediatric Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 CD34 F8 HBA1 VEGFA
2 platelet alpha granule lumen GO:0031093 8.62 F8 VEGFA

Biological processes related to Pediatric Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.16 CD34 VEGFA
2 positive regulation of angiogenesis GO:0045766 8.96 CD34 VEGFA
3 platelet degranulation GO:0002576 8.62 F8 VEGFA

Sources for Pediatric Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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