MCID: PDT045
MIFTS: 22

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

MalaCards integrated aliases for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections:

Name: Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections 53 59
Pediatric Autoimmune Disorders Associated with Streptococcus Infections 53 59
Pandas 53 59
Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus 53

Characteristics:

Orphanet epidemiological data:

59
pandas
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 59  
Rare neurological diseases


Summaries for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 66624Disease definitionPANDAS is an acronym for Pediatric Autoimmune Neuropsychiatric Disorders Associated with a group A beta-hemolytic Streptococcal infection and applied to a subgroup of children with obsessive-compulsive disorder (OCD) and/or tic disorders.EpidemiologyThe prevalence is unknown but the boy-to-girl ratio is 2.6:1.Clinical descriptionThe current diagnostic criteria for the PANDAS are: presence of OCD and/or a tic disorder, very young age at onset (prepubertal), sudden and dramatic onset of symptoms, association between streptococcal infections and episodic relapsing-remitting exacerbations manifesting as neuropsychiatric symptoms (motor hyperactivity or adventitious movements including choreiform movements or tics). The increased severity of symptoms usually persists for at least several weeks, but may last for several months or longer, followed by a slow, gradual improvement. The major distinctive feature of PANDAS is the temporal association between neuropsychiatric symptom exacerbations and streptococcal infections. Additional neuropsychiatric symptoms occur frequently: emotional lability, separation anxiety, anorexia, impulsivity, distractibility and motor hyperactivity characteristic of attention deficit hyperactivity disorder (ADHD). Comorbid disorders include major depression (36%), major dysthymia (6%) and separation anxiety disorder (20%).EtiologyThe etiology is uncertain. One theory is that streptococcal infections trigger an antibody response in some children that causes changes in the basal ganglia. No specific genetic factors have been identified.Diagnostic methodsDiagnosis of PANDAS is clinical. Neuroimaging studies may reveal increased basal ganglia volumes.Management and treatmentManagement includes standard interventions for obsessive-compulsive and tic disorders: cognitive-behavioural therapy, reversal therapy in the case of tic disorders and pharmacologic therapy (neuropsychiatric drugs, antibiotics to prevent infections and intravenous immunoglobulin therapy).Visit the Orphanet disease page for more resources.

MalaCards based summary : Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections, also known as pediatric autoimmune disorders associated with streptococcus infections, is related to obsessive-compulsive disorder and tic disorder. Related phenotypes are emotional lability and depressivity

Wikipedia : 76 Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a... more...

Related Diseases for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

Diseases related to Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 obsessive-compulsive disorder 10.1
2 tic disorder 10.1

Symptoms & Phenotypes for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

Human phenotypes related to Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections:

59 32 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 emotional lability 59 32 frequent (33%) Frequent (79-30%) HP:0000712
2 depressivity 59 32 frequent (33%) Frequent (79-30%) HP:0000716
3 chorea 59 32 frequent (33%) Frequent (79-30%) HP:0002072
4 sleep disturbance 59 32 frequent (33%) Frequent (79-30%) HP:0002360
5 developmental regression 59 32 frequent (33%) Frequent (79-30%) HP:0002376
6 arthralgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002829
7 irritability 59 32 frequent (33%) Frequent (79-30%) HP:0000737
8 attention deficit hyperactivity disorder 59 32 frequent (33%) Frequent (79-30%) HP:0007018
9 anorexia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002039
10 clumsiness 59 32 occasional (7.5%) Occasional (29-5%) HP:0002312
11 phonophobia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002183
12 impulsivity 59 32 frequent (33%) Frequent (79-30%) HP:0100710
13 personality changes 59 32 frequent (33%) Frequent (79-30%) HP:0000751
14 agoraphobia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000756
15 enuresis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000805
16 obsessive-compulsive trait 59 32 frequent (33%) Frequent (79-30%) HP:0008770
17 tics 59 32 hallmark (90%) Very frequent (99-80%) HP:0100033
18 recurrent streptococcus pneumoniae infections 59 32 occasional (7.5%) Occasional (29-5%) HP:0005366
19 oppositional defiant disorder 59 32 frequent (33%) Frequent (79-30%) HP:0010865
20 claustrophobia 59 32 occasional (7.5%) Occasional (29-5%) HP:0025253
21 separation insecurity 59 32 occasional (7.5%) Occasional (29-5%) HP:0031468
22 encopresis 59 32 occasional (7.5%) Occasional (29-5%) HP:0040183
23 abnormal fear/anxiety-related behavior 59 Frequent (79-30%)
24 mania 59 Excluded (0%)

Drugs & Therapeutics for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

Search Clinical Trials , NIH Clinical Center for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections

Genetic Tests for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

Anatomical Context for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

Publications for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

Variations for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

Expression for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

Search GEO for disease gene expression data for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections.

Pathways for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

GO Terms for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

Sources for Pediatric Autoimmune Neuropsychiatric Disorders Associated with...

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